All / DFGinNone / All

Total number of chains: 673
Active chains: 0
Total number of genes: 111
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 673 100.0% 9H8FA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC GRK2 ARBK1_HUMAN 3CIKA 2.75 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 669 0 None None Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 7PWDA 2.6 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8DS Type1 27 - 668 0 None S670A Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3KRWA 2.9 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BA1 Type1 30 - 671 0 None None Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3KRXA 3.1 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BA1 Type1 30 - 671 0 None None Beta-adrenergic receptor kinase 1
AGC GRK5 GRK5_HUMAN 6PJXA 1.96 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None E104K,R304H,G438E G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRFA 2.84 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ5 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRIA 2.9 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ8 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRJA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ9 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC PRKCB KPCB_HUMAN 9S9TA 3.425 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LY4 Type1 340 - 667 0 TPO500,TPO642,SEP661 D427N Protein kinase C beta type
AGC ROCK1 ROCK1_HUMAN 3TWJC 2.9 Inactive DFGin‑None in-out out-out nonTYR APEdihe_aaoii APEdist_oiio 07R Type1 7 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 5U7RD 3.33 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_onno 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 45 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_onnn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A 2.499 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP Allosteric, ATPlike 51 - 349 0 None None Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B 2.499 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP Allosteric, ATPlike 51 - 349 0 None None Ribosomal protein S6 kinase alpha-6
AGC RPS6KB1 KS6B1_HUMAN 4RLOA 2.527 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nnno 3T3 Type1 85 - 371 0 None None Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A 2.8 Inactive DFGin‑None in-out out-none nonTYR APEdihe_aanii APEdist_nnnn STU Type1 85 - 371 0 None None Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A 3.43 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 87 - 371 0 None None Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WF7A 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo FS9 Type1 83 - 374 0 TPO252 None Ribosomal protein S6 kinase beta-1
AGC STK38 STK38_HUMAN 6BXIA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 82 - 414 0 None None Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 83 - 414 0 None None Serine/threonine-protein kinase 38
CAMK AURKA AURKA_HUMAN 4C3PA 2.69 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaooi APEdist_oooo ACP ATPlike 125 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6DA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 126 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ODTA 2.021 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 392 0 None D274N,C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBJA 2.901 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo ATP, 9QK ATPlike, Allosteric 127 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA 2.1 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aaiii APEdist_nnni ADP, AMP ATPlike, Allosteric 124 - 391 0 None C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8JF4A 2.893 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnoo C0N Type1 127 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 8JMXA 2.95 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaooo APEdist_nnno E47 Type1 127 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 7AYIA 2.86 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn S9K Type1 125 - 392 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J4ZB 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 626 Type1 126 - 395 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0WA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_nioo ADN Type1 125 - 391 0 None H254Y Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H0ZA 2.92 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 45B Type1 128 - 388 0 None K124A,T287A,T288A Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DHFA 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_nnoo 0K6 Type1 128 - 389 0 None T287D,T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DHFB 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_nnoo 0K6 Type1 128 - 389 0 None T287D,T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 4PRJA 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_nnoo 2VU Type1 125 - 388 0 None K124A,Q154N,A203S,R251K,T287A,T288A,E336D Aurora kinase A
CAMK AURKA AURKA_HUMAN 5AAEA 3.11 Inactive DFGin‑None out-none in-out nonTYR APEdihe_aaioi APEdist_nnno 7HD Type1 126 - 388 0 None C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0UA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_oooo ADN Type1 126 - 391 0 None H254R Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDA 3.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno QMN Type1.5_Front 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDB 3.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo QMN Type1.5_Front 125 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UYNA 1.9 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn Y3M Type1.5_Front 125 - 391 0 None None Aurora kinase A
CAMK CAMK1D KCC1D_HUMAN 6QP5A 1.9 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 13 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T28AAA 1.55 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn M92 Type1 12 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 8BFSA 1.95 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn QNR Type1 12 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 8BFMA 1.7 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn QI6, QI6 Type1, Type3 12 - 301 0 None None Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1G KCC1G_HUMAN 2JAMA 1.7 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo J60 Type1 18 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1G
CAMK CAMK1G KCC1G_HUMAN 2JAMB 1.7 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo J60 Type1 16 - 301 0 None None Calcium/calmodulin-dependent protein kinase type 1G
CAMK CHEK2 CHK2_HUMAN 3I6UB 3.0 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 89 - 501 0 None K249R Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WA 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WC 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WE 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WG 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2
CAMK MARK2 MARK2_HUMAN 5KZ7A 3.2 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z2 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_HUMAN 5KZ8A 3.21 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno 6Z5 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_HUMAN 5KZ8B 3.21 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z5 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2
CAMK MARK4 MARK4_HUMAN 5ES1A 2.8 Inactive DFGin‑None in-in in-none nonTYR APEdihe_aanni APEdist_nnnn 5RC Type1 54 - 370 0 None None MAP/microtubule affinity-regulating kinase 4
CAMK MELK MELK_HUMAN 5TWYA 2.91 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoni APEdist_nnno 7LY Type1 2 - 333 0 None None Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 5MAIA 2.15 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 2 - 333 0 None None Maternal embryonic leucine zipper kinase
CAMK MKNK2 MKNK2_HUMAN 2AC5A 3.2 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 72 - 370 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
CAMK MKNK2 MKNK2_HUMAN 8P9BA 2.59 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn X8K Type1 72 - 369 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
CAMK PIM1 PIM1_HUMAN 4IAAA 2.85 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RTZ Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4XH6A 2.04 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii HUL Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1
CAMK PLK4 PLK4_HUMAN 4JXFA 2.4 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 631 Type1 4 - 267 0 None None Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN 4YURA 2.65 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 4J7 Type1 5 - 266 0 None None Serine/threonine-protein kinase PLK4
CAMK PRKAA1 AAPK1_HUMAN 7JHHA 3.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 7JHGA 3.47 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo TAK Type1 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 7M74A 3.93 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo TAK Type1 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4RERA 4.047 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REWA 4.58 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iiio STU Type1 20 - 559 0 None E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 7MYJC 2.95 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaiii APEdist_iooi 4O7 Type1 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVA 2.99 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU, C1V Type1, Allosteric 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVC 2.99 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, C1V Type1, Allosteric 9 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4ZHXC 2.99 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaoii APEdist_iiio 4O7, C1V Type1, Allosteric 9 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UA 2.77 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, CG7 Type1, Allosteric 8 - 550 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFC 3.924 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU, C1V Type1, Allosteric 10 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK STK11 STK11_HUMAN 8VSUC 2.86 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 41 - 347 0 None None Serine/threonine-protein kinase STK11
CK1 VRK1 VRK1_HUMAN 2KTYA 999.0 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio No_ligand No_ligand 1 - 360 0 None None Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 2KULA 999.0 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiio No_ligand No_ligand 1 - 360 0 None None Serine/threonine-protein kinase VRK1
CMGC CDK12 CDK12_HUMAN 8BUGH 3.53 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1B 2.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1H 2.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU2B 3.13 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVQ Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU3B 3.42 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSI Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU3H 3.42 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RSI Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E 3.134 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU6B 3.45 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU6H 3.45 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9B 3.51 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RRC Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUBH 3.42 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooo APEdist_iiii RNU Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUCH 3.85 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RKO Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUEB 3.25 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RVU Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUFB 3.3 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RW6 Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUFH 3.3 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RW6 Type1 715 - 1032 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUGB 3.53 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RPW Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUHB 3.79 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUHH 3.79 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUJB 3.62 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RUW Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUJH 3.62 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RUW Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUKB 3.41 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RWE Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUKH 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RWE Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BULB 3.4 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSU Type1 715 - 1039 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMB 3.36 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMH 3.36 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUOH 3.58 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RLC Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUQH 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ9 Type1 715 - 1035 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BURH 3.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQU Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUSE 3.26 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RMX Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1047 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 8BYAA 3.38 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 16 - 296 0 TPO159 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5UQ1C 3.201 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_iiii No_ligand No_ligand 1 - 289 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5OO1A 2.0 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 9Z2 Type1 4 - 298 0 None F80C,C177A Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1PYEA 2.0 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno PM1 Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2W05A 1.9 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nooo FRT Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5D1JA 1.8 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnno 56H Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QL8A 1.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo X01 Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QWJA 1.75 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo X6A Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QX4A 1.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo X4B Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3R9HA 2.1 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo Z67 Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RK5A 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 07Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RK7A 1.8 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 08Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RKBA 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 12Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RM6A 1.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 18Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3S0OA 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 50Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8RU8A 1.51 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno I74 Type1 1 - 298 0 None I10L,T14Q,V64I,K88E,K89V,D92K,Q131N Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3EZRA 1.9 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn EZR, EZR Type1, Allosteric 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK4 CDK4_HUMAN 6P8EB 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4
CMGC CDK4 CDK4_HUMAN 6P8FB 2.89 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4
CMGC CDK4 CDK4_HUMAN 2W9FB 2.85 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 5 - 295 0 None G43E,G47E,T172F Cyclin-dependent kinase 4
CMGC CDK7 CDK7_HUMAN 1UA2A 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2B 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2C 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2D 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BA 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 1 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BB 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 3 - 310 0 None S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BC 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo ANP ATPlike 8 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BD 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo ANP ATPlike 9 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9SB 2.78 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_niii PE3, PE3, YPK Allosteric, Allosteric, Type1 9 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 6O9L8 7.2 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 7EGC8 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 310 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 7ENA8 4.07 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8BYQ8 4.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_oooi No_ligand No_ligand 13 - 310 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8GXQHI 5.04 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 13 - 311 0 None K41A Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8GXSHI 4.16 Inactive DFGin‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None K41A Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 6XD3J 3.3 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii V0G Type1 10 - 312 0 SEP164 None Cyclin-dependent kinase 7
CMGC CDKL2 CDKL2_HUMAN 4BBMA 2.0 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaooi APEdist_iooo TC0 Type1 1 - 308 0 None T159D,Y161E Cyclin-dependent kinase-like 2
CMGC CLK1 CLK1_HUMAN 6KHDA 2.7 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aannn APEdist_ioon 3NG Type1 149 - 481 0 None None Dual specificity protein kinase CLK1
CMGC CSNK2A2 CSK22_HUMAN 3E3BX 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii CCK Type1 1 - 334 0 None None Casein kinase II subunit alpha'
CMGC DYRK1A DYR1A_HUMAN 6UIPA 3.7 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Q8J Type1 131 - 479 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT2A 2.9 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IE6 Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT3A 2.7 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IE7 Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT4A 3.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IFJ Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT6A 3.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IE8 Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FUFA 2.7 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IFO Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 9KQYA 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 8HLTB 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XSE Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 9KQYB 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1L6I Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC GSK3B GSK3B_HUMAN 8QJIA 3.02 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VNG Type1 36 - 381 0 PTR216 None Glycogen synthase kinase-3 beta
CMGC MAPK10 MK10_HUMAN 3OXIA 2.2 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno SYY Type1 46 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 3PTGA 2.43 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 932 Type1 46 - 401 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 1PMVA 2.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oioo 537 Type1 45 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 8VS0A 2.46 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo A1ACT Type1 45 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK11 MK11_HUMAN 3GC9A 2.05 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnno B45 Type1 3 - 348 0 None C119S,C162S Mitogen-activated protein kinase 11
CMGC MAPK14 MK14_HUMAN 4E6AA 2.09 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 0O9 Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E6CA 2.39 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 0O8 Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5N67A 1.9 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8ON Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 8X3MA 1.85 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo B8Z Allosteric 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4DLIA 1.91 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno IRG, IRG Allosteric, Allosteric 5 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EH4A 2.5 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo IRG, 0OL Allosteric, Type1 4 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3C5UA 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioo APEdist_nnoo P41, P41 Allosteric, Type1 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E5AX 1.87 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 3 - 353 0 None W197A Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OD6X 2.682 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 4 - 352 0 None Y323T Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OEFX 1.6 Inactive DFGin‑None in-in out-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 5 - 352 0 None Y323F Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ODYX 2.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 4 - 353 0 None Y323Q Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MGYA 2.1 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E5BA 2.0 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 4 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ODZX 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo No_ligand No_ligand 4 - 353 0 None Y323R Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5ETCA 2.422 Inactive DFGin‑None in-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 1 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WFCA 2.3 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 5 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MH0A 2.0 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 5 - 352 0 None F169A Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3IW6A 2.1 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo PP0 Type1 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3IW7A 2.4 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno IPK Type1 4 - 352 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2BAQA 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nioo PQB Type1 5 - 351 0 None V30I Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WBOA 2.16 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 2CH Type1 4 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5OMGA 2.0 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo 9Y8 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9YTYA 2.25 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno A1BB6 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUDA 2.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo N3F Type1 4 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUEA 2.7 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo 3FF Type1 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZSIA 2.4 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 52P Type1 6 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9MHBA 1.65 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno A1BLA Type1 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FC1X 2.4 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 52P Type1 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3BV2A 2.4 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnno P38 Type1 5 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OCGA 2.21 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn OCG Type1 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2GFSA 1.752 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno PQB Type1 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FMLA 2.1 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo FML Type1 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FSKA 2.0 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno RO6 Type1 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HA8A 2.48 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno 5JZ Type1 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4F9WA 2.0 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno LM4 Type1 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4FA2A 2.0 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo SB0 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4ZTHA 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo VVT Type1 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9O4LA 2.27 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanio APEdist_nnnn A1B8B Type1 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3O8PA 2.1 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnoo BMU Type1 5 - 351 0 None D168G Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OBGA 2.8 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 352 0 None F169G Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9D75A 2.13 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoo APEdist_nnnn A1A2L Type1 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9D7NA 1.973 Inactive DFGin‑None in-in out-none nonTYR APEdihe_aannn APEdist_nnnn A1A2O Type1 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EWQA 2.1 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioo APEdist_nnno MWL, MWL Type1, Allosteric 5 - 353 0 TPO180 None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4R3CA 2.06 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 3GF, 3GF Type1, Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9NYTA 2.16 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno A1B7S, F50 Type1, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP2A 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo P36, I46, I46 Type1, Allosteric, Allosteric 4 - 355 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP5A 2.3 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoni APEdist_nnno 52P, I46, I46 Type1, Allosteric, Allosteric 6 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK6 MK06_HUMAN 7AQBB 2.25 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 21 - 320 0 None None Mitogen-activated protein kinase 6
CMGC MAPK7 MK07_HUMAN 4IC8A 2.8 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaiio APEdist_iooo No_ligand No_ligand 40 - 390 0 None None Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4IC8B 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 40 - 390 0 None None Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 9LTAB 2.33 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaooi APEdist_iioo A1EKR Type1 50 - 393 0 None None Mitogen-activated protein kinase 7
CMGC MAPK8 MK08_HUMAN 4UX9B 2.34 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 362 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2G01B 3.5 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 73Q Type1 9 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2GMXB 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 877 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
CMGC MAPK9 MK09_HUMAN 7CMLA 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 1 - 364 0 None D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 7CMLB 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 1 - 364 0 None D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A Mitogen-activated protein kinase 9
NEK NEK2 NEK2_HUMAN 2XKDA 1.96 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnnn T3M Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XKEA 2.203 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanio APEdist_nnnn WI2 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XKFA 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno BX1 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 5M51A 1.899 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno NU6 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 5M57A 2.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno 4SP Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 9NFQC 3.25 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo ADP ATPlike 20 - 300 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQNA 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ADP ATPlike 21 - 300 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4K 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4L 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4M 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4N 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4O 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4P 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4Q 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4R 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4S 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4T 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQMA 2.1 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S76B 3.38 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnoo No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S76C 3.38 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73A 3.5 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaiio APEdist_nooo F9N Type1 21 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73B 3.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnoo F9N Type1 20 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73C 3.5 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 26 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S75B 3.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnno F9N Type1 20 - 300 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S75C 3.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 22 - 300 0 None None Serine/threonine-protein kinase Nek7
OTHER EIF2AK2 E2AK2_HUMAN 6D3LA 3.1 Inactive DFGin‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 258 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUA 2.903 Inactive DFGin‑None in-none in-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 254 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUB 2.903 Inactive DFGin‑None in-none in-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 254 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK3 E2AK3_HUMAN 4X7OA 2.65 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z6 Type1 585 - 1081 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 7MF0AAA 2.809 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn Z6P Type1 586 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQ9AAA 2.86 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn WPB Type1 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQDAAA 2.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn WPX Type1 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G31A 2.28 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 0WH Type1.5_Back 588 - 1080 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G34A 2.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 924 Type1.5_Back 588 - 1079 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4M7IA 2.34 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 27D Type1.5_Back 588 - 1080 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQEAAA 2.559 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn WQ2 Type1.5_Back 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6A 2.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 38O Type1 584 - 1004 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6B 2.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_oooo 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6C 2.8 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnno 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6D 2.8 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2
OTHER ERN1 ERN1_HUMAN 4Z7GA 2.6 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnni No_ligand No_ligand 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7GB 2.6 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnni No_ligand No_ligand 562 - 962 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7HA 2.9 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi 4L5 Type1 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER HASPIN HASP_HUMAN 9B2TK 2.99 Inactive DFGin‑None out-out in-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 470 - 798 0 None None Serine/threonine-protein kinase haspin
OTHER IKBKB IKKB_HUMAN 4E3CA 3.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_iioo No_ligand No_ligand 16 - 665 0 None S177E,S181E Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CE 3.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_iioo No_ligand No_ligand 16 - 665 0 None S177E,S181E Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER PINK1 PINK1_HUMAN 9EIHB 3.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiao APEdist_iiii No_ligand No_ligand 63 - 581 0 None None Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIIB 2.75 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiao APEdist_iiii No_ligand No_ligand 63 - 581 0 None None Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIJB 3.3 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiao APEdist_iiii No_ligand No_ligand 63 - 581 0 None None Serine/threonine-protein kinase PINK1, mitochondrial
OTHER TBK1 TBK1_HUMAN 6BNYA 3.341 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn E0M Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6BOEA 3.598 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni E0S Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ0A 3.19 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno F8M Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ4A 3.2 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni F8P Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ5A 3.354 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn F8S Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSRA 3.15 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KHT Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSUA 2.75 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KJB Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWPA 3.065 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni BX7 Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWQA 3.0 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni 1FV Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1
OTHER TTK TTK_HUMAN 7CHMA 2.65 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoni APEdist_nnoo FZF Type1 516 - 794 0 TPO675,TPO686 None Dual specificity protein kinase TTK
OTHER WNK1 WNK1_HUMAN 4PWNA 1.84 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 210 - 482 0 None None Serine/threonine-protein kinase WNK1
OTHER WNK3 WNK3_HUMAN 5O23A 2.25 Inactive DFGin‑None out-na out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 136 - 405 0 SEP304 None Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O23B 2.25 Inactive DFGin‑None out-na out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 132 - 408 0 SEP304 None Serine/threonine-protein kinase WNK3
RGC NPR1 ANPRA_HUMAN 9BCSA 4.4 Pseudo DFGin‑None out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ATP ATPlike 503 - 1055 0 None None Atrial natriuretic peptide receptor 1
STE MAP2K1 MP2K1_HUMAN 5YT3B 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8YP4A 2.35 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo WNT Type1 34 - 384 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K6 MP2K6_HUMAN 3ENMA 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 46 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMB 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 49 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMC 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 48 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMD 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 45 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K7 MP2K7_HUMAN 5B2MA 3.06 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 105 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVLA 2.9 Inactive DFGin‑None in-na none-out nonTYR APEdihe_aaiai APEdist_nnoi 1XZ Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVMA 2.9 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni 21I Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVNA 2.9 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 2I8 Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 9HZ0A 2.25 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni A1IY7 Type1 101 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVKA 2.05 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2I5 Type1.5_Back 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6IB2A 2.1 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 862 Type1.5_Front 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP3K5 M3K5_HUMAN 5VIOC 2.84 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VILC 2.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 7KACA 1.85 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno W9D Type1 7 - 304 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8DA 1.641 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITC Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8EA 1.631 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITA Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8FA 1.393 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITB Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A 1.76 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo A1JAF Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo B49 Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQFA 2.246 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo F97 Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9LA 2.332 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo 2YE Type1 7 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26A 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26B 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26C 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26D 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L25A 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 7 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L25B 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 6 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7SIUA 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oioo 9ID Type1.5_Back 5 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7SIUB 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9ID Type1.5_Back 16 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE OXSR1 OXSR1_HUMAN 2VWIA 2.15 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 13 - 292 0 None None Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 4O0TB 2.6 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 255 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3Q4ZB 1.887 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 250 - 541 0 None S259I,K299R,D389N,L516I Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 7VTOB 2.59 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 107 Type1 255 - 542 0 TPO423 None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5DEYB 2.1 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_oooo 59T Type1 255 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5IMEB 2.217 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 6BZ Type1 250 - 541 0 None None Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4FIGB 3.01 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE STK10 STK10_HUMAN 5AJQA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nooo DB8 Type1 24 - 312 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5AJQB 2.2 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aanii APEdist_nnnn DB8 Type1 25 - 312 0 None None Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 4O27B 3.185 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 30 - 309 0 None T190E Serine/threonine-protein kinase 24
STE STK26 STK26_HUMAN 3GGFA 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo GVD Type1 17 - 300 0 None None Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 3GGFB 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo GVD Type1 18 - 297 0 None None Serine/threonine-protein kinase 26
STE STK3 STK3_HUMAN 4LG4F 2.42 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 18 - 310 0 None D146N Serine/threonine-protein kinase 3
STE STRADA STRAA_HUMAN 8VSUB 2.86 Pseudo DFGin‑None out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ADP ATPlike 60 - 401 0 None None STE20-related kinase adapter protein alpha
STE TNIK TNIK_HUMAN 2X7FE 2.8 Inactive DFGin‑None in-none none-none nonTYR APEdihe_aanni APEdist_nnnn 824 Type1 14 - 309 0 None None TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 6T6DA 2.56 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 204 - 499 0 None Q207D Activin receptor type-1
TKL BRAF BRAF_HUMAN 4XV3B 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4FK3B 2.65 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaooi APEdist_nnoo No_ligand No_ligand 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3OG7B 2.45 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 449 - 720 0 None K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6UUOA 3.288 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaoii APEdist_nnno QH1 Type1 450 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4H58A 3.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnio 10Z Type1 448 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3PRFB 2.9 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno FP3 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5CSWA 2.66 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5ITAB 1.95 Inactive DFGin‑None out-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6DC Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2UA 3.78 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MBJA 3.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo DFS Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MBJB 3.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo DFS Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 8TVMD 2.1 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnni VDC Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97B 2.65 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AB 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
TKL LIMK1 LIMK1_HUMAN 5HVKC 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 329 - 633 0 TPO508 D460N LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5NXCL 2.25 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiai APEdist_nnno 9DB Type1 330 - 632 0 None None LIM domain kinase 1
TKL LRRK2 LRRK2_HUMAN 8TZHA 3.9 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni A1N Type1 627 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 9CHOA 7.8 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni A1N Type1 543 - 2527 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2
TKL MAP3K12 M3K12_HUMAN 9CDXA 2.38 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaooi APEdist_nnno A1AZP Type1 117 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12
TKL MAP3K7 M3K7_HUMAN 8GW3A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 27 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 5JH6A 2.365 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno T92 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 5GJGA 2.61 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6V5 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL RAF1 RAF1_HUMAN 8CPDA 3.46 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CPDB 3.46 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 3OMVA 4.0 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nioo SM5 Type1 340 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFA 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFB 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL RIPK2 RIPK2_HUMAN 5W5JA 2.85 Inactive DFGin‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn 9WS Type1 9 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5W5JB 2.85 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoi APEdist_nnnn 9WS Type1 10 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 6FU5B 3.26 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno E7N Type1 5 - 316 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 9F3VA 1.943 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn A1H90 Type1 9 - 314 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 9F3VB 1.943 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1H90 Type1 9 - 315 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR8A 2.79 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XYW Type1.5_Back 9 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2
TYR ALK ALK_HUMAN 2YJRA 1.9 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1101 - 1402 0 None F1174L ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 6EDLA 2.799 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao J4M Type1 1093 - 1399 0 None None ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5IMXA 2.12 Inactive DFGin‑None in-in out-out TYR APEdihe_oiiai APEdist_aaai CZ4 Type1 1109 - 1400 0 None None ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEA 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai 0JF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEB 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao 0JF Type1 1094 - 1402 0 None C1097S ALK tyrosine kinase receptor
TYR AXL UFO_HUMAN 5U6BA 2.84 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan 7YS Type1 521 - 813 0 None None Tyrosine-protein kinase receptor UFO
TYR AXL UFO_HUMAN 5U6BC 2.84 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan 7YS Type1 521 - 813 0 None None Tyrosine-protein kinase receptor UFO
TYR BTK BTK_HUMAN 3PIYA 2.55 Inactive DFGin‑None out-out out-out TYR APEdihe_oiiai APEdist_aaao 585 Type1 391 - 658 0 None None Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3PJ2A 1.75 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 04K Type1.5_Back 391 - 659 0 None None Tyrosine-protein kinase BTK
TYR CSK CSK_HUMAN 3D7TA 2.899 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 188 - 450 0 None K361A,K362A Tyrosine-protein kinase CSK
TYR EGFR EGFR_HUMAN 4RIWB 3.1 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIWD 3.1 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXB 3.1 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXD 3.1 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYB 2.981 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYD 2.981 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8EMEA 3.32 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnan APEdist_aaan No_ligand No_ligand 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GOPA 2.8 Inactive DFGin‑None in-na none-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 676 - 1018 0 None K745M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXIB 3.0 Inactive DFGin‑None out-out none-none TYR APEdihe_nniai APEdist_aaai 8BS Type1 702 - 1004 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0C 3.1 Inactive DFGin‑None out-out out-none TYR APEdihe_nniai APEdist_aaai XA4 Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7U98A 3.42 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan M1O Type1 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7ZYQB 2.1 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao V58 Type1 700 - 984 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JIVA 3.5 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai HKI Type1.5_Back 700 - 984 0 None T790M Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 4PDOA 2.104 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 590 - 875 0 None None Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 4PDOB 2.104 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 590 - 875 0 None None Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5IA1A 2.036 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai ZZL Type1 605 - 888 0 None None Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOOA 1.25 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,Y742F Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOFA 1.2 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 906 0 None Y596F Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QODA 1.15 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y602F Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOIA 1.25 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOLA 1.07 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnan APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,S768G Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4P4CA 1.599 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 25Q Type1 613 - 904 0 None None Ephrin type-A receptor 3
TYR EPHB1 EPHB1_HUMAN 7KPMA 1.608 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 611 - 888 0 PTR647 None Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 7KPLA 2.705 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 611 - 888 0 PTR647 None Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 6UMWA 1.982 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai CTC Type1.5_Back 611 - 889 0 PTR647 None Ephrin type-B receptor 1
TYR EPHB2 EPHB2_HUMAN 3ZFMA 2.27 Inactive DFGin‑None in-none none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 615 - 894 0 None None Ephrin type-B receptor 2
TYR EPHB3 EPHB3_HUMAN 3ZFYA 2.2 Inactive DFGin‑None in-out none-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 632 - 905 0 None None Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 3ZFYB 2.2 Inactive DFGin‑None in-none none-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 631 - 905 0 None None Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 5L6OA 1.88 Inactive DFGin‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai 6P6 Type1 632 - 905 0 None A899P Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 5L6PA 2.26 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6P8 Type1 632 - 905 0 None A899P Ephrin type-B receptor 3
TYR EPHB4 EPHB4_HUMAN 2YN8A 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 608 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8B 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 606 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWUA 2.0 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 7X1 Type1 609 - 887 0 None Y774E Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWVA 1.9 Inactive DFGin‑None in-in none-none TYR APEdihe_niiai APEdist_aaai 7X3 Type1 606 - 885 0 None Y774E Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWWA 1.9 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 7X2 Type1 609 - 887 0 None Y774E Ephrin type-B receptor 4
TYR ERBB2 ERBB2_HUMAN 7JXHB 3.27 Inactive DFGin‑None out-out none-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 996 0 None None Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHC 3.27 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHD 3.27 Inactive DFGin‑None out-out in-none TYR APEdihe_niiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHF 3.27 Inactive DFGin‑None out-out out-none TYR APEdihe_nniai APEdist_aaai VOY Type1.5_Back 713 - 991 0 None None Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHG 3.27 Inactive DFGin‑None out-out in-none TYR APEdihe_nniai APEdist_aaai VOY Type1.5_Back 706 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHH 3.27 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3PP0A 2.25 Inactive DFGin‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai 03Q Type1.5_Back 706 - 993 0 None M706A,Q711L,M712L Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3PP0B 2.25 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai 03Q Type1.5_Back 706 - 1009 0 None M706A,Q711L,M712L Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3RCDA 3.21 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 03P Type1.5_Back 713 - 1022 0 None None Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3RCDC 3.21 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 03P Type1.5_Back 713 - 1022 0 None None Receptor tyrosine-protein kinase erbB-2
TYR FGFR1 FGFR1_HUMAN 4F65A 2.26 Inactive DFGin‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0S9 Type1 464 - 765 0 None C488A,C584S Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4NKAB 2.19 Inactive DFGin‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 2K7 Type1 458 - 765 0 None C488A,C584S Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4F65B 2.26 Inactive DFGin‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0S9 Type1.5_Back 460 - 763 0 None C488A,C584S Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6C18B 2.3 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan YY5 Type1.5_Back 466 - 762 0 None C488A,C584S Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6MZWB 2.2 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 463 - 762 0 None None Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 8U1FB 3.33 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao UIM Type1.5_Back 472 - 765 0 None None Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8STGB 3.79 Inactive DFGin‑None in-out none-out TYR APEdihe_oiiai APEdist_aaai WCJ Type1.5_Back 472 - 765 0 None None Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 9U3NB 3.25 Inactive DFGin‑None in-in none-out TYR APEdihe_iiiai APEdist_aaao A1ENT Type1.5_Back 470 - 764 0 None V564F Fibroblast growth factor receptor 2
TYR FGFR4 FGFR4_HUMAN 4TYEA 2.8 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 451 - 753 0 None None Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFJA 3.25 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None V550M Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFFA 2.7 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None V550L Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5JKGA 2.352 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None None Fibroblast growth factor receptor 4
TYR HCK HCK_HUMAN 3VS0A 2.934 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VS0 Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS0B 2.934 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VS0 Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS1B 2.464 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VSA Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS2B 2.609 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VSB Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS7A 3.001 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan KS1 Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS1A 2.464 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VSA Type1.5_Back 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 1JQHA 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHB 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHC 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3QQUB 2.9 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 01P Type1 988 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3QQUD 2.9 Inactive DFGin‑None in-out out-out TYR APEdihe_oiiai APEdist_aaai 01P Type1 989 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 4D2RA 2.1 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai DYK Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW5A 2.14 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LGX Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW6A 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LGW Type1 986 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW7A 2.11 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai LGV Type1 987 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXQA 2.3 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai GD5 Type1 980 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXRA 2.4 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 8LN Type1 980 - 1283 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3I81A 2.08 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai EBI Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXSA 1.9 Inactive DFGin‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai OZN Type1 980 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3D94A 2.3 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai D94 Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIAAA 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 986 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIBBB 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYICCC 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIDDD 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIEEE 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIFFF 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIGGG 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIHHH 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNA 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNB 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNC 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZND 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNE 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNF 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNG 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNH 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 1I44A 2.4 Inactive DFGin‑None in-out none-out TYR APEdihe_nnoai APEdist_aaai ACP ATPlike 1013 - 1310 0 None C1008S,Y1011F,D1188A Insulin receptor
TYR INSR INSR_HUMAN 1P14A 1.9 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 1005 - 1310 0 None C1008S,D1159N Insulin receptor
TYR INSR INSR_HUMAN 4IBMA 1.8 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IR1 Type1 1009 - 1309 0 None K1278N Insulin receptor
TYR INSR INSR_HUMAN 4IBMB 1.8 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai IR1 Type1 1014 - 1310 0 None K1278N Insulin receptor
TYR INSR INSR_HUMAN 5E1SA 2.264 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 5JA Type1 1010 - 1310 0 None None Insulin receptor
TYR INSR INSR_HUMAN 3EKKA 2.1 Inactive DFGin‑None in-out none-none TYR APEdihe_niiai APEdist_aaai GS2 Type1 1007 - 1309 0 None C1008S,D1159N Insulin receptor
TYR INSR INSR_HUMAN 3EKNA 2.2 Inactive DFGin‑None in-out out-out TYR APEdihe_oiiai APEdist_aaai GS3 Type1 1011 - 1310 0 None C1008S,D1159N Insulin receptor
TYR INSR INSR_HUMAN 5HHWA 1.79 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 60O Type1.5_Front 1005 - 1310 0 None C1008S,D1159N Insulin receptor
TYR ITK ITK_HUMAN 3MIYA 1.67 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan B49 Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3MJ1A 1.72 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 614 Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PQNA 1.71 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 2W6 Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4MF0B 2.67 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 29Z Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PPCA 2.95 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VW Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PPCB 2.95 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VW Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3QGWB 2.1 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan L7A Type1 358 - 616 0 None None Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SM2B 2.3 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUB 2.5 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3V5JB 2.59 Inactive DFGin‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan 0F2 Type1 357 - 620 0 None None Tyrosine-protein kinase ITK/TSK
TYR JAK1-1 JAK1_HUMAN 4L01A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 565 - 850 0 None V658F Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L01B 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 565 - 849 0 None V658F Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00A 1.8 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 564 - 850 0 None None Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00B 1.8 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 565 - 850 0 None None Tyrosine-protein kinase JAK1
TYR JAK2-1 JAK2_HUMAN 5I4NA 1.54 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 809 0 None E596A,V617F,W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None V617F,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA 1.75 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A 2.2 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4B 2.1 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVPA 2.01 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C09A 1.9 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 538 - 809 0 None I559F,W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CA 1.6 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao EKT Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CB 1.6 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao EKT Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IA 3.192 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IB 3.192 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8NA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UA 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UB 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 538 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA2A 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q9X Type1 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4A 2.1 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao Q8U Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WA 1.83 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 36H Type1 536 - 810 0 None None Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WB 1.83 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 36H Type1 536 - 810 0 None None Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B99A 1.6 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9EA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BABA 1.55 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q8N Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BAKA 1.65 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao AD5 Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AA 1.7 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 809 0 None W659A,R683S,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AB 1.7 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 808 0 None W659A,R683S,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIJA 2.04 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIKB 2.6 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 584 Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WILA 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao YDJ Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIMA 2.55 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WINA 2.38 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5USZA 2.103 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT0A 2.102 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT1A 1.95 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 7DZ Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT2A 1.75 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3YT Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT3A 1.501 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao IK1 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT4A 2.0 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao DQX Type1 537 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT5A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 2HB Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT6A 1.645 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 8MY Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BRWA 2.031 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 5BS Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BS0A 1.541 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao E4V Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BSSA 2.1 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 4SP Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6M9HA 1.79 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao J9D Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OAVA 1.939 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao M3A Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBBA 1.904 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M3Y Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBFA 1.71 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M4G Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBLA 2.061 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M4P Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OCCA 2.03 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M57 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6XJKA 2.024 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao V4D Type1 539 - 807 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYOA 2.161 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VPS Type1 539 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYQA 1.859 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao VPJ Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7SZWA 1.906 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao DVY Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PA 2.04 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E3W Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PB 2.04 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E3W Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T1TA 2.08 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E8I Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA3A 1.4 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q8U Type1 536 - 812 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX0A 1.85 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX1A 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AD5 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX2A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao Q2Q Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND5A 2.4 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao A1BXA Type1 536 - 809 0 None None Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND3A 1.62 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao A1BW6 Type1 536 - 808 0 None None Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5TQ3A 2.69 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GZ Type1.5_Back 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5TQ3B 2.69 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GZ Type1.5_Back 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2
TYR KDR VGFR2_HUMAN 1VR2A 2.4 Inactive DFGin‑None in-in none-out TYR APEdihe_iioai APEdist_aaao No_ligand No_ligand 820 - 1168 0 PTR1059 E990V Vascular endothelial growth factor receptor 2
TYR LYN LYN_HUMAN 3A4OX 3.0 Inactive DFGin‑None in-in in-out TYR APEdihe_ooiai APEdist_aaai STU Type1 238 - 505 0 None None Tyrosine-protein kinase Lyn
TYR MERTK MERTK_HUMAN 5TD2B 2.68 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 577 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MH7B 2.51 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 577 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TC0B 2.24 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 578 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB0A 1.74 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TD2A 2.68 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan 7AE Type1 577 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OAMB 2.65 Inactive DFGin‑None none-none none-out TYR APEdihe_nniai APEdist_aaao V6H Type1 576 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3TCPA 2.69 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan CKJ Type1 577 - 863 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3TCPB 2.69 Inactive DFGin‑None out-none none-out TYR APEdihe_nniai APEdist_aaao CKJ Type1 576 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4M3QA 2.718 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan 24K Type1 578 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MH7A 2.51 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan MH7 Type1 577 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MHAB 2.59 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan 4MH Type1 577 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5K0KB 2.545 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 6Q1 Type1 577 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TC0A 2.24 Inactive DFGin‑None none-none none-none TYR APEdihe_nniai APEdist_aaai 79Y Type1 578 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5U6CA 2.1 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 7YS Type1 572 - 864 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5U6CB 2.1 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 7YS Type1 575 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB1A 1.93 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan C6F Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB2A 1.78 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan R6N Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AVZA 2.04 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4N Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW0A 1.893 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4Q Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW3A 1.99 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4Z Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7M5ZA 3.06 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan YR7 Type1 577 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 6MEPB 2.893 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 9VS Type1.5_Back 578 - 862 0 None None Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3EFKA 2.2 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKB 2.2 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4PMTA 2.1 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 31Y Type1 501 - 787 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5I8AA 2.33 Inactive DFGin‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 69C Type1 501 - 787 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6IQNA 2.54 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai AQ6 Type1 502 - 790 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 7XAFA 3.001 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai FKT Type1 498 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6J5LA 2.3 Inactive DFGin‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai B9C Type1 502 - 790 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PMEB 3.0 Inactive DFGin‑None in-out out-none TYR APEdihe_niiai APEdist_aaai OOY Type1 499 - 791 0 SEP677 None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 9DAIA 2.864 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai STU Type1 501 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 7VKOA 2.9 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 7GI Type1 502 - 793 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4AOJB 2.75 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai V4Z Type1 500 - 791 0 None None High affinity nerve growth factor receptor
TYR NTRK2 NTRK2_HUMAN 4AT3A 1.77 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LTI Type1 527 - 822 0 None None BDNF/NT-3 growth factors receptor
TYR PTK2 FAK1_HUMAN 2IJMA 2.187 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao ATP ATPlike 414 - 688 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 7PI4DDD 2.24 Inactive DFGin‑None in-in out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 415 - 687 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 9SDIB 2.53 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 414 - 685 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 3BZ3A 2.2 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao YAM Type1 414 - 689 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU9A 2.4 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 4GU Type1 414 - 685 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4KABA 2.71 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 4KA Type1 412 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6I8ZA 1.99 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao H82 Type1 414 - 688 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4I4EA 1.55 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 1BQ Type1 414 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU6A 1.95 Inactive DFGin‑None in-in out-out TYR APEdihe_iiiai APEdist_aaao 10N Type1 414 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU6B 1.95 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao 10N Type1 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YOJA 1.361 Inactive DFGin‑None in-in out-none TYR APEdihe_nniai APEdist_aaai P4N Type1 414 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1A 1.784 Inactive DFGin‑None in-in out-out TYR APEdihe_niiai APEdist_aaao P7N Type1 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1B 1.784 Inactive DFGin‑None in-in out-out TYR APEdihe_iiiai APEdist_aaao P7N Type1 411 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1C 1.784 Inactive DFGin‑None in-in out-out TYR APEdihe_niiai APEdist_aaao P7N Type1 412 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1D 1.784 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao P7N Type1 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9A 1.925 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao P9K Type1 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9B 1.925 Inactive DFGin‑None in-in out-out TYR APEdihe_niiai APEdist_aaao P9K Type1 414 - 684 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9C 1.925 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao P9K Type1 414 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9D 1.925 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao P9K Type1 412 - 685 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVSB 1.81 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao PVT Type1 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVSD 1.81 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao PVT Type1 412 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVYC 1.918 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao P1E Type1 411 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVYD 1.918 Inactive DFGin‑None in-out none-out TYR APEdihe_niiai APEdist_aaao P1E Type1 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVA 2.298 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao Q2H Type1 414 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVB 2.298 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao Q2H Type1 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVC 2.298 Inactive DFGin‑None in-in out-out TYR APEdihe_iiiai APEdist_aaao Q2H Type1 414 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVD 2.298 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao Q2H Type1 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2B FAK2_HUMAN 3FZOA 2.2 Inactive DFGin‑None in-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 420 - 691 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 8YGXA 2.0 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 420 - 691 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 3CC6A 1.6 Inactive DFGin‑None in-in out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 415 - 692 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 8XOXA 1.9 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao YAM Type1 417 - 692 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 5TOBA 2.117 Inactive DFGin‑None in-none none-none TYR APEdihe_nnnai APEdist_aaan YAM Type1 420 - 690 0 None None Protein-tyrosine kinase 2-beta
TYR ROS1 ROS1_HUMAN 7Z5WA 2.254 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao IDW Type1 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5WB 2.254 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao IDW Type1 1937 - 2226 0 None None Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5XA 2.035 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao AWJ Type1 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5XB 2.035 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao AWJ Type1 1937 - 2226 0 None None Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 9QEKA 2.205 Inactive DFGin‑None in-out none-out TYR APEdihe_niiai APEdist_aaao A1I6Z Type1 1934 - 2229 0 None G2032R Proto-oncogene tyrosine-protein kinase ROS
TYR RYK RYK_HUMAN 6TUAA 2.38 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 298 - 607 0 None None Tyrosine-protein kinase RYK
TYR SRC SRC_HUMAN 8HAQA 2.27 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan L1N Type1 260 - 536 0 None None Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 8JF3B 2.846 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan C0N Type1 261 - 536 0 None None Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 1YOMB 2.9 Inactive DFGin‑None in-none none-out TYR APEdihe_nnoai APEdist_aaao P01 Type1 258 - 536 0 None S345N,A370S,Y419W Proto-oncogene tyrosine-protein kinase Src
TYR TNK2 ACK1_HUMAN 8HMTD 3.17 Inactive DFGin‑None in-out in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1
TYR TYK2-1 TYK2_HUMAN 5C03A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AGS ATPlike 579 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C03B 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AGS ATPlike 580 - 870 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4A 2.12 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao NM7 Type1 579 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4B 2.12 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao NM7 Type1 579 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98A 1.87 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZRU Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98B 1.87 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZRU Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98C 1.87 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZRU Type1 578 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99A 1.71 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZS3 Type1 578 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99B 1.71 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZS3 Type1 579 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99C 1.71 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZS3 Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AA 1.83 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZSB Type1 577 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AB 1.83 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZSB Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AC 1.83 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZSB Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDA 1.92 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 7GL Type1 581 - 866 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDB 1.92 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 7GL Type1 581 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 3ZONA 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao IK1 Type1 577 - 870 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRA 2.56 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LAJ Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRB 2.56 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LAJ Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVA 1.8 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3SM Type1 580 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVB 1.8 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3SM Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLA 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao KZJ Type1 581 - 866 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLB 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao KZJ Type1 581 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEA 1.96 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L8Y Type1 581 - 863 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEB 1.96 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L8Y Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFA 2.39 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L91 Type1 580 - 865 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFB 2.39 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L91 Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHA 2.73 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L9A Type1 581 - 866 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHB 2.73 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L9A Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPA 2.35 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LB7 Type1 580 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPB 2.35 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LB7 Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQA 2.11 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LB4 Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQB 2.11 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LB4 Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OA 2.82 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VZJ Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OB 2.82 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VZJ Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QA 2.27 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VZG Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QB 2.27 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VZG Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5A 2.32 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZOQ Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5B 2.32 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZOQ Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6A 1.96 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZOI Type1 572 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6B 1.96 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZOI Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01A 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao UNL Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01B 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao UNL Type1 579 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 4GIIA 2.31 Inactive DFGin‑None in-in in-out TYR APEdihe_oiiai APEdist_aaai 0X6 Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2

All / DFGinNone / All

Total number of chains: 855
Active chains: 0
Total number of genes: 137
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 855 100.0% 9H8FA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CAMK SRK2E SRK2E_ARATH 3ZUTA 2.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 10 - 319 0 None D160A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3ZUTB 2.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 319 0 None D160A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3ZUUA 2.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 10 - 319 0 None None Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3ZUUB 2.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 319 0 None None Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2I SRK2I_ARATH 3UC3A 1.9 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 11 - 319 0 None D57A,K58A Serine/threonine-protein kinase SRK2I Arabidopsis thaliana
CMGC MPK6 MPK6_ARATH 6DTLB 2.753 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 33 - 395 0 None None Mitogen-activated protein kinase 6 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRB 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 65 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRE 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 65 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRG 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 64 - 327 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
TKL BAK1 BAK1_ARATH 3TL8G 2.5 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 274 - 578 0 TPO324,TPO446,TPO449,TPO450 None BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 Arabidopsis thaliana
TKL BIK1 BIK1_ARATH 5TOSA 2.35 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 52 - 360 0 SEP253 None Serine/threonine-protein kinase BIK1 Arabidopsis thaliana
TKL BIK1 BIK1_ARATH 5TOSB 2.35 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 52 - 360 0 SEP253 None Serine/threonine-protein kinase BIK1 Arabidopsis thaliana
TKL CARK1 CARK1_ARATH 5XD6A 1.898 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 50 - 350 0 None None Protein CYTOSOLIC ABA RECEPTOR KINASE 1 Arabidopsis thaliana
TKL CARK1 CARK1_ARATH 5XD6B 1.898 Inactive DFGin‑None out-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 50 - 350 0 None None Protein CYTOSOLIC ABA RECEPTOR KINASE 1 Arabidopsis thaliana
TKL CTR1 CTR1_ARATH 3P86B 2.496 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 543 - 810 0 None D676N Serine/threonine-protein kinase CTR1 Arabidopsis thaliana
AGC GRK2 ARBK1_BOVIN 1OMWA 2.5 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 1YM7A 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 1YM7C 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 1YM7D 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 2BCJA 3.061 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 667 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3UZSA 4.52 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiio APEdist_iiii No_ligand No_ligand 29 - 671 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3UZTA 3.51 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 30 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3PSCA 2.67 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3PVUA 2.48 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRW Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3PVWA 2.49 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRX Type1 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC PRKACA KAPCA_BOVIN 4C35A 2.19 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NU3 Type1.5_Back 11 - 351 0 SEP11,SEP140,TPO198,SEP339 F55Y,M121L,V124L,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
CMGC CDK7 G0SFC6_CHATD 6Z4XB 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 78 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
CMGC CDK7 G0SFC6_CHATD 6Z4XE 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 77 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIA 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIB 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 213 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIC 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYID 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 214 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIE 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIF 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 213 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIG 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 212 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIH 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJA 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 630 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJB 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJC 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 210 - 632 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJD 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PKNG Q8NM29_CORGL 7MXBA 2.2 Inactive DFGin‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MAP Type1 52 - 728 0 None None non-specific serine/threonine protein kinase Corynebacterium glutamicum
OTHER POMK SG196_DANRE 5GZAA 2.0 Pseudo DFGin‑None none-na in-out nonTYR APEdihe_aaioo APEdist_iioo ADP, ZZ1 ATPlike, Allosteric 53 - 342 0 None None Protein O-mannose kinase Danio rerio
OTHER PAN3 PAN3_DROME 4BWPA 3.6 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AN2 ATPlike 379 - 787 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Drosophila melanogaster
OTHER PAN3 PAN3_DROME 4BWPB 3.6 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AN2 ATPlike 379 - 787 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Drosophila melanogaster
TYR PTK2 FAK1_CHICK 4D4RA 1.55 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 414 - 685 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D4RB 1.55 Inactive DFGin‑None out-out out-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 412 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D4SA 2.0 Inactive DFGin‑None in-in none-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D4YA 1.8 Inactive DFGin‑None in-in none-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D58A 1.95 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 414 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D5KA 1.75 Inactive DFGin‑None in-in none-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6TY3A 6.32 Inactive DFGin‑None in-out out-out TYR APEdihe_iiiai APEdist_aaao No_ligand No_ligand 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6TY3B 6.32 Inactive DFGin‑None in-out out-out TYR APEdihe_iiiai APEdist_aaao No_ligand No_ligand 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2JKMA 2.31 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao BII Type1 413 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2J0MB 2.8 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 4ST Type1 414 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2JKQA 2.6 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai VG8 Type1 414 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2JKKA 2.0 Inactive DFGin‑None in-in out-none TYR APEdihe_nniai APEdist_aaai BI9 Type1 413 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2JKOA 1.65 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai BIJ Type1 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4BRXA 2.05 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao KGW Type1 413 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4C7TA 2.05 Inactive DFGin‑None in-in out-none TYR APEdihe_nniai APEdist_aaai 5RI Type1 414 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D5HA 1.75 Inactive DFGin‑None in-out none-out TYR APEdihe_niiai APEdist_aaao 9RM Type1 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6GCRA 2.3 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao EUW Type1 413 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6GCWA 2.0 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao EUQ Type1 414 - 685 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6GCWB 2.0 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao EUQ Type1 414 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6GCXA 1.553 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao EUW Type1 413 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2J0JA 2.8 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao 4ST Type1 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2J0KA 3.0 Inactive DFGin‑None in-in none-out TYR APEdihe_niiai APEdist_aaao 4ST Type1 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2J0KB 3.0 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao 4ST Type1 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR SRC SRC_CHICK 2QI8B 2.32 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 258 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3OF0A 2.7 Inactive DFGin‑None in-none none-out TYR APEdihe_nnoai APEdist_aaao No_ligand No_ligand 257 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3OF0B 2.7 Inactive DFGin‑None out-none none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 257 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EN7B 2.81 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 260 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5D10B 2.7 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan 563 Type1 257 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 6HVFA 2.1 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan GUT Type1 257 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3QLFA 2.75 Inactive DFGin‑None in-none none-out TYR APEdihe_nniai APEdist_aaao PD5 Type1 258 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EN6B 2.39 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnan APEdist_aaan KS5 Type1 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EN7A 2.81 Inactive DFGin‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan ABJ Type1 256 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4O2PA 2.1 Inactive DFGin‑None out-out out-out TYR APEdihe_nniai APEdist_aaao 11V Type1 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 7AH3A 1.95 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan RCK Type1 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 8K79B 2.8 Inactive DFGin‑None in-none out-none TYR APEdihe_nniai APEdist_aaai IYC Type1 269 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4LGGA 2.41 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan VGG Type1 264 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4LGGB 2.41 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan VGG Type1 264 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 2HWOB 2.5 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan RBS Type1 258 - 533 0 None S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 2HWPA 2.48 Inactive DFGin‑None none-none none-none TYR APEdihe_nniai APEdist_aaai DJK Type1 256 - 533 0 None S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4LGHA 2.84 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan 0JN Type1 257 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4LGHB 2.84 Inactive DFGin‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan 0JN Type1 259 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4MCVB 2.73 Inactive DFGin‑None in-none in-out TYR APEdihe_noiai APEdist_aaao 29K Type1 257 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5T0PA 2.5 Inactive DFGin‑None in-out in-none TYR APEdihe_nnnai APEdist_aaan 73A Type1 257 - 533 0 None V313C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5T0PB 2.5 Inactive DFGin‑None in-out in-none TYR APEdihe_nnnai APEdist_aaan 73A Type1 258 - 533 0 None V313C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 2QLQA 2.33 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan SR2, SR2 Type1, Allosteric 256 - 533 0 None S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5TEHA 2.99 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao S56 Type1.5_Back 256 - 533 0 None V281C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3QLFB 2.75 Inactive DFGin‑None out-none in-out TYR APEdihe_nniai APEdist_aaao PD5 Type1.5_Front 258 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
AGC GRK2 ARBK1_HUMAN 3CIKA 2.75 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 669 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
AGC GRK2 ARBK1_HUMAN 7PWDA 2.6 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8DS Type1 27 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Homo sapiens
AGC GRK2 ARBK1_HUMAN 3KRWA 2.9 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BA1 Type1 30 - 671 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
AGC GRK2 ARBK1_HUMAN 3KRXA 3.1 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BA1 Type1 30 - 671 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
AGC GRK5 GRK5_HUMAN 6PJXA 1.96 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None E104K,R304H,G438E G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 8UAQA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 9BRFA 2.84 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ5 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 9BRIA 2.9 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ8 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 9BRJA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ9 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC PRKCB KPCB_HUMAN 9S9TA 3.425 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LY4 Type1 340 - 667 0 TPO500,TPO642,SEP661 D427N Protein kinase C beta type Homo sapiens
AGC ROCK1 ROCK1_HUMAN 3TWJC 2.9 Inactive DFGin‑None in-out out-out nonTYR APEdihe_aaoii APEdist_oiio 07R Type1 7 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK2 ROCK2_HUMAN 5U7RD 3.33 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_onno 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 45 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_onnn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A 2.499 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP Allosteric, ATPlike 51 - 349 0 None None Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B 2.499 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP Allosteric, ATPlike 51 - 349 0 None None Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 4RLOA 2.527 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nnno 3T3 Type1 85 - 371 0 None None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 3A60A 2.8 Inactive DFGin‑None in-out out-none nonTYR APEdihe_aanii APEdist_nnnn STU Type1 85 - 371 0 None None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 3A61A 3.43 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 87 - 371 0 None None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 3WF7A 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo FS9 Type1 83 - 374 0 TPO252 None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC STK38 STK38_HUMAN 6BXIA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 82 - 414 0 None None Serine/threonine-protein kinase 38 Homo sapiens
AGC STK38 STK38_HUMAN 6BXIB 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 83 - 414 0 None None Serine/threonine-protein kinase 38 Homo sapiens
CAMK AURKA AURKA_HUMAN 4C3PA 2.69 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaooi APEdist_oooo ACP ATPlike 125 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2C6DA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 126 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ODTA 2.021 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 392 0 None D274N,C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OBJA 2.901 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo ATP, 9QK ATPlike, Allosteric 127 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 9GUCA 2.1 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aaiii APEdist_nnni ADP, AMP ATPlike, Allosteric 124 - 391 0 None C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8JF4A 2.893 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnoo C0N Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8JMXA 2.95 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaooo APEdist_nnno E47 Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 7AYIA 2.86 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn S9K Type1 125 - 392 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2J4ZB 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 626 Type1 126 - 395 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4O0WA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_nioo ADN Type1 125 - 391 0 None H254Y Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3H0ZA 2.92 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 45B Type1 128 - 388 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4DHFA 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_nnoo 0K6 Type1 128 - 389 0 None T287D,T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4DHFB 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_nnoo 0K6 Type1 128 - 389 0 None T287D,T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4PRJA 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_nnoo 2VU Type1 125 - 388 0 None K124A,Q154N,A203S,R251K,T287A,T288A,E336D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5AAEA 3.11 Inactive DFGin‑None out-none in-out nonTYR APEdihe_aaioi APEdist_nnno 7HD Type1 126 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4O0UA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_oooo ADN Type1 126 - 391 0 None H254R Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4UZDA 3.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno QMN Type1.5_Front 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4UZDB 3.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo QMN Type1.5_Front 125 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4UYNA 1.9 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn Y3M Type1.5_Front 125 - 391 0 None None Aurora kinase A Homo sapiens
CAMK CAMK1D KCC1D_HUMAN 6QP5A 1.9 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 13 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens
CAMK CAMK1D KCC1D_HUMAN 6T28AAA 1.55 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn M92 Type1 12 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens
CAMK CAMK1D KCC1D_HUMAN 8BFSA 1.95 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn QNR Type1 12 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens
CAMK CAMK1D KCC1D_HUMAN 8BFMA 1.7 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn QI6, QI6 Type1, Type3 12 - 301 0 None None Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens
CAMK CAMK1G KCC1G_HUMAN 2JAMA 1.7 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo J60 Type1 18 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1G Homo sapiens
CAMK CAMK1G KCC1G_HUMAN 2JAMB 1.7 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo J60 Type1 16 - 301 0 None None Calcium/calmodulin-dependent protein kinase type 1G Homo sapiens
CAMK CHEK2 CHK2_HUMAN 3I6UB 3.0 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 89 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CAMK CHEK2 CHK2_HUMAN 3I6WA 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CAMK CHEK2 CHK2_HUMAN 3I6WC 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CAMK CHEK2 CHK2_HUMAN 3I6WE 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CAMK CHEK2 CHK2_HUMAN 3I6WG 3.25 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 92 - 501 0 None K249R Serine/threonine-protein kinase Chk2 Homo sapiens
CAMK MARK2 MARK2_HUMAN 5KZ7A 3.2 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z2 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
CAMK MARK2 MARK2_HUMAN 5KZ8A 3.21 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno 6Z5 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
CAMK MARK2 MARK2_HUMAN 5KZ8B 3.21 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z5 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
CAMK MARK4 MARK4_HUMAN 5ES1A 2.8 Inactive DFGin‑None in-in in-none nonTYR APEdihe_aanni APEdist_nnnn 5RC Type1 54 - 370 0 None None MAP/microtubule affinity-regulating kinase 4 Homo sapiens
CAMK MELK MELK_HUMAN 5TWYA 2.91 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoni APEdist_nnno 7LY Type1 2 - 333 0 None None Maternal embryonic leucine zipper kinase Homo sapiens
CAMK MELK MELK_HUMAN 5MAIA 2.15 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 2 - 333 0 None None Maternal embryonic leucine zipper kinase Homo sapiens
CAMK MKNK2 MKNK2_HUMAN 2AC5A 3.2 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 72 - 370 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
CAMK MKNK2 MKNK2_HUMAN 8P9BA 2.59 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn X8K Type1 72 - 369 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
CAMK PIM1 PIM1_HUMAN 4IAAA 2.85 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RTZ Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 4XH6A 2.04 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii HUL Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PLK4 PLK4_HUMAN 4JXFA 2.4 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 631 Type1 4 - 267 0 None None Serine/threonine-protein kinase PLK4 Homo sapiens
CAMK PLK4 PLK4_HUMAN 4YURA 2.65 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 4J7 Type1 5 - 266 0 None None Serine/threonine-protein kinase PLK4 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 7JHHA 3.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 7JHGA 3.47 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo TAK Type1 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 7M74A 3.93 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo TAK Type1 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 4RERA 4.047 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 4REWA 4.58 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iiio STU Type1 20 - 559 0 None E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 7MYJC 2.95 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaiii APEdist_iooi 4O7 Type1 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 5EZVA 2.99 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU, C1V Type1, Allosteric 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 5EZVC 2.99 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, C1V Type1, Allosteric 9 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 4ZHXC 2.99 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaoii APEdist_iiio 4O7, C1V Type1, Allosteric 9 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 6B1UA 2.77 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, CG7 Type1, Allosteric 8 - 550 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 4CFFC 3.924 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU, C1V Type1, Allosteric 10 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK STK11 STK11_HUMAN 8VSUC 2.86 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 41 - 347 0 None None Serine/threonine-protein kinase STK11 Homo sapiens
CK1 VRK1 VRK1_HUMAN 2KTYA 999.0 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio No_ligand No_ligand 1 - 360 0 None None Serine/threonine-protein kinase VRK1 Homo sapiens
CK1 VRK1 VRK1_HUMAN 2KULA 999.0 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiio No_ligand No_ligand 1 - 360 0 None None Serine/threonine-protein kinase VRK1 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUGH 3.53 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU1B 2.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU1H 2.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU2B 3.13 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVQ Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU3B 3.42 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSI Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU3H 3.42 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RSI Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU5E 3.134 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU6B 3.45 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU6H 3.45 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU9B 3.51 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RRC Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUBH 3.42 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooo APEdist_iiii RNU Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUCH 3.85 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RKO Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUEB 3.25 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RVU Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUFB 3.3 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RW6 Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUFH 3.3 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RW6 Type1 715 - 1032 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUGB 3.53 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RPW Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUHB 3.79 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUHH 3.79 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUJB 3.62 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RUW Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUJH 3.62 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RUW Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUKB 3.41 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RWE Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUKH 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RWE Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BULB 3.4 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSU Type1 715 - 1039 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUMB 3.36 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUMH 3.36 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUOH 3.58 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RLC Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUQH 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ9 Type1 715 - 1035 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BURH 3.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQU Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUSE 3.26 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RMX Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 9FMRB 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1047 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK2 CDK2_HUMAN 8BYAA 3.38 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 16 - 296 0 TPO159 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 5UQ1C 3.201 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_iiii No_ligand No_ligand 1 - 289 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 5OO1A 2.0 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 9Z2 Type1 4 - 298 0 None F80C,C177A Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1PYEA 2.0 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno PM1 Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2W05A 1.9 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nooo FRT Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 5D1JA 1.8 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnno 56H Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3QL8A 1.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo X01 Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3QWJA 1.75 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo X6A Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3QX4A 1.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo X4B Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3R9HA 2.1 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo Z67 Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3RK5A 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 07Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3RK7A 1.8 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 08Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3RKBA 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 12Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3RM6A 1.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 18Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3S0OA 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 50Z Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 8RU8A 1.51 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno I74 Type1 1 - 298 0 None I10L,T14Q,V64I,K88E,K89V,D92K,Q131N Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3EZRA 1.9 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn EZR, EZR Type1, Allosteric 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK4 CDK4_HUMAN 6P8EB 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4 Homo sapiens
CMGC CDK4 CDK4_HUMAN 6P8FB 2.89 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4 Homo sapiens
CMGC CDK4 CDK4_HUMAN 2W9FB 2.85 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 5 - 295 0 None G43E,G47E,T172F Cyclin-dependent kinase 4 Homo sapiens
CMGC CDK7 CDK7_HUMAN 1UA2A 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 1UA2B 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 1UA2C 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 1UA2D 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9BA 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 1 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9BB 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 3 - 310 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9BC 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo ANP ATPlike 8 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9BD 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo ANP ATPlike 9 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9SB 2.78 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_niii PE3, PE3, YPK Allosteric, Allosteric, Type1 9 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 6O9L8 7.2 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 7EGC8 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 7ENA8 4.07 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8BYQ8 4.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_oooi No_ligand No_ligand 13 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8GXQHI 5.04 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 13 - 311 0 None K41A Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8GXSHI 4.16 Inactive DFGin‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None K41A Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 6XD3J 3.3 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii V0G Type1 10 - 312 0 SEP164 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDKL2 CDKL2_HUMAN 4BBMA 2.0 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaooi APEdist_iooo TC0 Type1 1 - 308 0 None T159D,Y161E Cyclin-dependent kinase-like 2 Homo sapiens
CMGC CLK1 CLK1_HUMAN 6KHDA 2.7 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aannn APEdist_ioon 3NG Type1 149 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CMGC CSNK2A2 CSK22_HUMAN 3E3BX 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii CCK Type1 1 - 334 0 None None Casein kinase II subunit alpha' Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 6UIPA 3.7 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Q8J Type1 131 - 479 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 9FT2A 2.9 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IE6 Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 9FT3A 2.7 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IE7 Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 9FT4A 3.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IFJ Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 9FT6A 3.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IE8 Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 9FUFA 2.7 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IFO Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK2 DYRK2_HUMAN 9KQYA 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
CMGC DYRK2 DYRK2_HUMAN 8HLTB 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XSE Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
CMGC DYRK2 DYRK2_HUMAN 9KQYB 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1L6I Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
CMGC GSK3B GSK3B_HUMAN 8QJIA 3.02 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VNG Type1 36 - 381 0 PTR216 None Glycogen synthase kinase-3 beta Homo sapiens
CMGC MAPK10 MK10_HUMAN 3OXIA 2.2 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno SYY Type1 46 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 3PTGA 2.43 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 932 Type1 46 - 401 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 1PMVA 2.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oioo 537 Type1 45 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 8VS0A 2.46 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo A1ACT Type1 45 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK11 MK11_HUMAN 3GC9A 2.05 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnno B45 Type1 3 - 348 0 None C119S,C162S Mitogen-activated protein kinase 11 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4E6AA 2.09 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 0O9 Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4E6CA 2.39 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 0O8 Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5N67A 1.9 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8ON Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 8X3MA 1.85 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo B8Z Allosteric 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4DLIA 1.91 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno IRG, IRG Allosteric, Allosteric 5 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4EH4A 2.5 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo IRG, 0OL Allosteric, Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3C5UA 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioo APEdist_nnoo P41, P41 Allosteric, Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4E5AX 1.87 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 3 - 353 0 None W197A Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3OD6X 2.682 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 4 - 352 0 None Y323T Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3OEFX 1.6 Inactive DFGin‑None in-in out-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 5 - 352 0 None Y323F Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3ODYX 2.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 4 - 353 0 None Y323Q Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3MGYA 2.1 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4E5BA 2.0 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 4 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3ODZX 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo No_ligand No_ligand 4 - 353 0 None Y323R Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5ETCA 2.422 Inactive DFGin‑None in-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 1 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 1WFCA 2.3 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 5 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3MH0A 2.0 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 5 - 352 0 None F169A Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3IW6A 2.1 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo PP0 Type1 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3IW7A 2.4 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno IPK Type1 4 - 352 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2BAQA 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nioo PQB Type1 5 - 351 0 None V30I Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 1WBOA 2.16 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 2CH Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5OMGA 2.0 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo 9Y8 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9YTYA 2.25 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno A1BB6 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3QUDA 2.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo N3F Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3QUEA 2.7 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo 3FF Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3ZSIA 2.4 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 52P Type1 6 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9MHBA 1.65 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno A1BLA Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3FC1X 2.4 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 52P Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3BV2A 2.4 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnno P38 Type1 5 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3OCGA 2.21 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn OCG Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2GFSA 1.752 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno PQB Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3FMLA 2.1 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo FML Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3FSKA 2.0 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno RO6 Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HA8A 2.48 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno 5JZ Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4F9WA 2.0 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno LM4 Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4FA2A 2.0 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo SB0 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4ZTHA 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo VVT Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9O4LA 2.27 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanio APEdist_nnnn A1B8B Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3O8PA 2.1 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnoo BMU Type1 5 - 351 0 None D168G Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3OBGA 2.8 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 352 0 None F169G Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9D75A 2.13 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoo APEdist_nnnn A1A2L Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9D7NA 1.973 Inactive DFGin‑None in-in out-none nonTYR APEdihe_aannn APEdist_nnnn A1A2O Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4EWQA 2.1 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioo APEdist_nnno MWL, MWL Type1, Allosteric 5 - 353 0 TPO180 None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4R3CA 2.06 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 3GF, 3GF Type1, Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9NYTA 2.16 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno A1B7S, F50 Type1, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HP2A 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo P36, I46, I46 Type1, Allosteric, Allosteric 4 - 355 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HP5A 2.3 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoni APEdist_nnno 52P, I46, I46 Type1, Allosteric, Allosteric 6 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK6 MK06_HUMAN 7AQBB 2.25 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 21 - 320 0 None None Mitogen-activated protein kinase 6 Homo sapiens
CMGC MAPK7 MK07_HUMAN 4IC8A 2.8 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaiio APEdist_iooo No_ligand No_ligand 40 - 390 0 None None Mitogen-activated protein kinase 7 Homo sapiens
CMGC MAPK7 MK07_HUMAN 4IC8B 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 40 - 390 0 None None Mitogen-activated protein kinase 7 Homo sapiens
CMGC MAPK7 MK07_HUMAN 9LTAB 2.33 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaooi APEdist_iioo A1EKR Type1 50 - 393 0 None None Mitogen-activated protein kinase 7 Homo sapiens
CMGC MAPK8 MK08_HUMAN 4UX9B 2.34 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 2G01B 3.5 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 73Q Type1 9 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 2GMXB 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 877 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK9 MK09_HUMAN 7CMLA 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 1 - 364 0 None D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A Mitogen-activated protein kinase 9 Homo sapiens
CMGC MAPK9 MK09_HUMAN 7CMLB 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 1 - 364 0 None D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A Mitogen-activated protein kinase 9 Homo sapiens
NEK NEK2 NEK2_HUMAN 2XKDA 1.96 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnnn T3M Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 2XKEA 2.203 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanio APEdist_nnnn WI2 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 2XKFA 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno BX1 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 5M51A 1.899 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno NU6 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 5M57A 2.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno 4SP Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK7 NEK7_HUMAN 9NFQC 3.25 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo ADP ATPlike 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 2WQNA 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ADP ATPlike 21 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4K 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4L 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4M 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4N 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4O 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4P 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4Q 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4R 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4S 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8EJ4T 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 2WQMA 2.1 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S76B 3.38 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnoo No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S76C 3.38 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S73A 3.5 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaiio APEdist_nooo F9N Type1 21 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S73B 3.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnoo F9N Type1 20 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S73C 3.5 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 26 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S75B 3.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnno F9N Type1 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S75C 3.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 22 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
OTHER EIF2AK2 E2AK2_HUMAN 6D3LA 3.1 Inactive DFGin‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 258 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
OTHER EIF2AK2 E2AK2_HUMAN 3UIUA 2.903 Inactive DFGin‑None in-none in-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 254 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
OTHER EIF2AK2 E2AK2_HUMAN 3UIUB 2.903 Inactive DFGin‑None in-none in-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 254 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 4X7OA 2.65 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z6 Type1 585 - 1081 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 7MF0AAA 2.809 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn Z6P Type1 586 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 8EQ9AAA 2.86 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn WPB Type1 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 8EQDAAA 2.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn WPX Type1 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 4G31A 2.28 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 0WH Type1.5_Back 588 - 1080 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 4G34A 2.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 924 Type1.5_Back 588 - 1079 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 4M7IA 2.34 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 27D Type1.5_Back 588 - 1080 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 8EQEAAA 2.559 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn WQ2 Type1.5_Back 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6A 2.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 38O Type1 584 - 1004 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6B 2.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_oooo 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6C 2.8 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnno 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6D 2.8 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4Z7GA 2.6 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnni No_ligand No_ligand 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4Z7GB 2.6 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnni No_ligand No_ligand 562 - 962 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4Z7HA 2.9 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi 4L5 Type1 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER HASPIN HASP_HUMAN 9B2TK 2.99 Inactive DFGin‑None out-out in-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 470 - 798 0 None None Serine/threonine-protein kinase haspin Homo sapiens
OTHER IKBKB IKKB_HUMAN 4E3CA 3.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_iioo No_ligand No_ligand 16 - 665 0 None S177E,S181E Inhibitor of nuclear factor kappa-B kinase subunit beta Homo sapiens
OTHER IKBKB IKKB_HUMAN 4E3CE 3.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_iioo No_ligand No_ligand 16 - 665 0 None S177E,S181E Inhibitor of nuclear factor kappa-B kinase subunit beta Homo sapiens
OTHER PINK1 PINK1_HUMAN 9EIHB 3.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiao APEdist_iiii No_ligand No_ligand 63 - 581 0 None None Serine/threonine-protein kinase PINK1, mitochondrial Homo sapiens
OTHER PINK1 PINK1_HUMAN 9EIIB 2.75 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiao APEdist_iiii No_ligand No_ligand 63 - 581 0 None None Serine/threonine-protein kinase PINK1, mitochondrial Homo sapiens
OTHER PINK1 PINK1_HUMAN 9EIJB 3.3 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiao APEdist_iiii No_ligand No_ligand 63 - 581 0 None None Serine/threonine-protein kinase PINK1, mitochondrial Homo sapiens
OTHER TBK1 TBK1_HUMAN 6BNYA 3.341 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn E0M Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TBK1 TBK1_HUMAN 6BOEA 3.598 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni E0S Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TBK1 TBK1_HUMAN 6CQ0A 3.19 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno F8M Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TBK1 TBK1_HUMAN 6CQ4A 3.2 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni F8P Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TBK1 TBK1_HUMAN 6CQ5A 3.354 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn F8S Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TBK1 TBK1_HUMAN 6RSRA 3.15 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KHT Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TBK1 TBK1_HUMAN 6RSUA 2.75 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KJB Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TBK1 TBK1_HUMAN 4IWPA 3.065 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni BX7 Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TBK1 TBK1_HUMAN 4IWQA 3.0 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni 1FV Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1 Homo sapiens
OTHER TTK TTK_HUMAN 7CHMA 2.65 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoni APEdist_nnoo FZF Type1 516 - 794 0 TPO675,TPO686 None Dual specificity protein kinase TTK Homo sapiens
OTHER WNK1 WNK1_HUMAN 4PWNA 1.84 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 210 - 482 0 None None Serine/threonine-protein kinase WNK1 Homo sapiens
OTHER WNK3 WNK3_HUMAN 5O23A 2.25 Inactive DFGin‑None out-na out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 136 - 405 0 SEP304 None Serine/threonine-protein kinase WNK3 Homo sapiens
OTHER WNK3 WNK3_HUMAN 5O23B 2.25 Inactive DFGin‑None out-na out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 132 - 408 0 SEP304 None Serine/threonine-protein kinase WNK3 Homo sapiens
RGC NPR1 ANPRA_HUMAN 9BCSA 4.4 Pseudo DFGin‑None out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ATP ATPlike 503 - 1055 0 None None Atrial natriuretic peptide receptor 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3B 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3D 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8YP4A 2.35 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo WNT Type1 34 - 384 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3ENMA 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 46 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3ENMB 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 49 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3ENMC 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 48 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3ENMD 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 45 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5B2MA 3.06 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 105 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVLA 2.9 Inactive DFGin‑None in-na none-out nonTYR APEdihe_aaiai APEdist_nnoi 1XZ Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVMA 2.9 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni 21I Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVNA 2.9 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 2I8 Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 9HZ0A 2.25 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni A1IY7 Type1 101 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVKA 2.05 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2I5 Type1.5_Back 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6IB2A 2.1 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 862 Type1.5_Front 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VIOC 2.84 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VILC 2.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7KACA 1.85 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno W9D Type1 7 - 304 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9H8DA 1.641 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITC Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9H8EA 1.631 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITA Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9H8FA 1.393 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITB Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9QT6A 1.76 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo A1JAF Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6NG0A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo B49 Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6CQFA 2.246 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo F97 Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7R9LA 2.332 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo 2YE Type1 7 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L26A 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L26B 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L26C 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L26D 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L25A 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 7 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L25B 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 6 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7SIUA 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oioo 9ID Type1.5_Back 5 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7SIUB 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9ID Type1.5_Back 16 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWIA 2.15 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 13 - 292 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE PAK1 PAK1_HUMAN 4O0TB 2.6 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 255 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 3Q4ZB 1.887 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 250 - 541 0 None S259I,K299R,D389N,L516I Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 7VTOB 2.59 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 107 Type1 255 - 542 0 TPO423 None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5DEYB 2.1 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_oooo 59T Type1 255 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5IMEB 2.217 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 6BZ Type1 250 - 541 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIGB 3.01 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE STK10 STK10_HUMAN 5AJQA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nooo DB8 Type1 24 - 312 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 5AJQB 2.2 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aanii APEdist_nnnn DB8 Type1 25 - 312 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK24 STK24_HUMAN 4O27B 3.185 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 30 - 309 0 None T190E Serine/threonine-protein kinase 24 Homo sapiens
STE STK26 STK26_HUMAN 3GGFA 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo GVD Type1 17 - 300 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 3GGFB 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo GVD Type1 18 - 297 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE STK3 STK3_HUMAN 4LG4F 2.42 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 18 - 310 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STRADA STRAA_HUMAN 8VSUB 2.86 Pseudo DFGin‑None out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ADP ATPlike 60 - 401 0 None None STE20-related kinase adapter protein alpha Homo sapiens
STE TNIK TNIK_HUMAN 2X7FE 2.8 Inactive DFGin‑None in-none none-none nonTYR APEdihe_aanni APEdist_nnnn 824 Type1 14 - 309 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6T6DA 2.56 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL BRAF BRAF_HUMAN 4XV3B 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4FK3B 2.65 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaooi APEdist_nnoo No_ligand No_ligand 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 3OG7B 2.45 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 449 - 720 0 None K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6UUOA 3.288 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaoii APEdist_nnno QH1 Type1 450 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4H58A 3.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnio 10Z Type1 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 3PRFB 2.9 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno FP3 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5CSWA 2.66 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5ITAB 1.95 Inactive DFGin‑None out-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6DC Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6V2UA 3.78 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4MBJA 3.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo DFS Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4MBJB 3.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo DFS Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL IRAK4 IRAK4_HUMAN 8TVMD 2.1 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnni VDC Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4U97B 2.65 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4U9AB 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL LIMK1 LIMK1_HUMAN 5HVKC 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 329 - 633 0 TPO508 D460N LIM domain kinase 1 Homo sapiens
TKL LIMK1 LIMK1_HUMAN 5NXCL 2.25 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiai APEdist_nnno 9DB Type1 330 - 632 0 None None LIM domain kinase 1 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8TZHA 3.9 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni A1N Type1 627 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 9CHOA 7.8 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni A1N Type1 543 - 2527 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL MAP3K12 M3K12_HUMAN 9CDXA 2.38 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaooi APEdist_nnno A1AZP Type1 117 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 8GW3A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 27 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 5JH6A 2.365 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno T92 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 5GJGA 2.61 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6V5 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL RAF1 RAF1_HUMAN 8CPDA 3.46 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 8CPDB 3.46 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 3OMVA 4.0 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nioo SM5 Type1 340 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 8CHFA 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 8CHFB 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5W5JA 2.85 Inactive DFGin‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn 9WS Type1 9 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5W5JB 2.85 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoi APEdist_nnnn 9WS Type1 10 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 6FU5B 3.26 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno E7N Type1 5 - 316 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 9F3VA 1.943 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn A1H90 Type1 9 - 314 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 9F3VB 1.943 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1H90 Type1 9 - 315 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5AR8A 2.79 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XYW Type1.5_Back 9 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TYR ALK ALK_HUMAN 2YJRA 1.9 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1101 - 1402 0 None F1174L ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 6EDLA 2.799 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao J4M Type1 1093 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 5IMXA 2.12 Inactive DFGin‑None in-in out-out TYR APEdihe_oiiai APEdist_aaai CZ4 Type1 1109 - 1400 0 None None ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 4DCEA 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai 0JF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 4DCEB 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao 0JF Type1 1094 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
TYR AXL UFO_HUMAN 5U6BA 2.84 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan 7YS Type1 521 - 813 0 None None Tyrosine-protein kinase receptor UFO Homo sapiens
TYR AXL UFO_HUMAN 5U6BC 2.84 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan 7YS Type1 521 - 813 0 None None Tyrosine-protein kinase receptor UFO Homo sapiens
TYR BTK BTK_HUMAN 3PIYA 2.55 Inactive DFGin‑None out-out out-out TYR APEdihe_oiiai APEdist_aaao 585 Type1 391 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR BTK BTK_HUMAN 3PJ2A 1.75 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 04K Type1.5_Back 391 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR CSK CSK_HUMAN 3D7TA 2.899 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 188 - 450 0 None K361A,K362A Tyrosine-protein kinase CSK Homo sapiens
TYR EGFR EGFR_HUMAN 4RIWB 3.1 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIWD 3.1 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIXB 3.1 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIXD 3.1 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIYB 2.981 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIYD 2.981 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8EMEA 3.32 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnan APEdist_aaan No_ligand No_ligand 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3GOPA 2.8 Inactive DFGin‑None in-na none-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 676 - 1018 0 None K745M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXIB 3.0 Inactive DFGin‑None out-out none-none TYR APEdihe_nniai APEdist_aaai 8BS Type1 702 - 1004 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7KY0C 3.1 Inactive DFGin‑None out-out out-none TYR APEdihe_nniai APEdist_aaai XA4 Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7U98A 3.42 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan M1O Type1 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7ZYQB 2.1 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao V58 Type1 700 - 984 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2JIVA 3.5 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai HKI Type1.5_Back 700 - 984 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EPHA2 EPHA2_HUMAN 4PDOA 2.104 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 590 - 875 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 4PDOB 2.104 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 590 - 875 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 5IA1A 2.036 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai ZZL Type1 605 - 888 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QOOA 1.25 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,Y742F Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QOFA 1.2 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 906 0 None Y596F Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QODA 1.15 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y602F Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QOIA 1.25 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QOLA 1.07 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnan APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,S768G Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 4P4CA 1.599 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 25Q Type1 613 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
TYR EPHB1 EPHB1_HUMAN 7KPMA 1.608 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 611 - 888 0 PTR647 None Ephrin type-B receptor 1 Homo sapiens
TYR EPHB1 EPHB1_HUMAN 7KPLA 2.705 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 611 - 888 0 PTR647 None Ephrin type-B receptor 1 Homo sapiens
TYR EPHB1 EPHB1_HUMAN 6UMWA 1.982 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai CTC Type1.5_Back 611 - 889 0 PTR647 None Ephrin type-B receptor 1 Homo sapiens
TYR EPHB2 EPHB2_HUMAN 3ZFMA 2.27 Inactive DFGin‑None in-none none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 615 - 894 0 None None Ephrin type-B receptor 2 Homo sapiens
TYR EPHB3 EPHB3_HUMAN 3ZFYA 2.2 Inactive DFGin‑None in-out none-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 632 - 905 0 None None Ephrin type-B receptor 3 Homo sapiens
TYR EPHB3 EPHB3_HUMAN 3ZFYB 2.2 Inactive DFGin‑None in-none none-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 631 - 905 0 None None Ephrin type-B receptor 3 Homo sapiens
TYR EPHB3 EPHB3_HUMAN 5L6OA 1.88 Inactive DFGin‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai 6P6 Type1 632 - 905 0 None A899P Ephrin type-B receptor 3 Homo sapiens
TYR EPHB3 EPHB3_HUMAN 5L6PA 2.26 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6P8 Type1 632 - 905 0 None A899P Ephrin type-B receptor 3 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 2YN8A 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 608 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 2YN8B 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 606 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 2VWUA 2.0 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 7X1 Type1 609 - 887 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 2VWVA 1.9 Inactive DFGin‑None in-in none-none TYR APEdihe_niiai APEdist_aaai 7X3 Type1 606 - 885 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 2VWWA 1.9 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 7X2 Type1 609 - 887 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 7JXHB 3.27 Inactive DFGin‑None out-out none-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 996 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 7JXHC 3.27 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 7JXHD 3.27 Inactive DFGin‑None out-out in-none TYR APEdihe_niiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 7JXHF 3.27 Inactive DFGin‑None out-out out-none TYR APEdihe_nniai APEdist_aaai VOY Type1.5_Back 713 - 991 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 7JXHG 3.27 Inactive DFGin‑None out-out in-none TYR APEdihe_nniai APEdist_aaai VOY Type1.5_Back 706 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 7JXHH 3.27 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai VOY Type1.5_Back 707 - 992 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 3PP0A 2.25 Inactive DFGin‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai 03Q Type1.5_Back 706 - 993 0 None M706A,Q711L,M712L Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 3PP0B 2.25 Inactive DFGin‑None out-out in-out TYR APEdihe_oiiai APEdist_aaai 03Q Type1.5_Back 706 - 1009 0 None M706A,Q711L,M712L Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 3RCDA 3.21 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 03P Type1.5_Back 713 - 1022 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 3RCDC 3.21 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 03P Type1.5_Back 713 - 1022 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 4F65A 2.26 Inactive DFGin‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0S9 Type1 464 - 765 0 None C488A,C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 4NKAB 2.19 Inactive DFGin‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 2K7 Type1 458 - 765 0 None C488A,C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 4F65B 2.26 Inactive DFGin‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0S9 Type1.5_Back 460 - 763 0 None C488A,C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 6C18B 2.3 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan YY5 Type1.5_Back 466 - 762 0 None C488A,C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 6MZWB 2.2 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 463 - 762 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8U1FB 3.33 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao UIM Type1.5_Back 472 - 765 0 None None Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8STGB 3.79 Inactive DFGin‑None in-out none-out TYR APEdihe_oiiai APEdist_aaai WCJ Type1.5_Back 472 - 765 0 None None Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 9U3NB 3.25 Inactive DFGin‑None in-in none-out TYR APEdihe_iiiai APEdist_aaao A1ENT Type1.5_Back 470 - 764 0 None V564F Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 4TYEA 2.8 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 451 - 753 0 None None Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 5XFJA 3.25 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None V550M Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 5XFFA 2.7 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None V550L Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 5JKGA 2.352 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None None Fibroblast growth factor receptor 4 Homo sapiens
TYR HCK HCK_HUMAN 3VS0A 2.934 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VS0 Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 3VS0B 2.934 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VS0 Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 3VS1B 2.464 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VSA Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 3VS2B 2.609 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VSB Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 3VS7A 3.001 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan KS1 Type1 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 3VS1A 2.464 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan VSA Type1.5_Back 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR IGF1R IGF1R_HUMAN 1JQHA 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 1JQHB 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 1JQHC 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3QQUB 2.9 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 01P Type1 988 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3QQUD 2.9 Inactive DFGin‑None in-out out-out TYR APEdihe_oiiai APEdist_aaai 01P Type1 989 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 4D2RA 2.1 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai DYK Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3NW5A 2.14 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LGX Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3NW6A 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LGW Type1 986 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3NW7A 2.11 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai LGV Type1 987 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5FXQA 2.3 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai GD5 Type1 980 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5FXRA 2.4 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 8LN Type1 980 - 1283 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3I81A 2.08 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai EBI Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5FXSA 1.9 Inactive DFGin‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai OZN Type1 980 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3D94A 2.3 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai D94 Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIAAA 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 986 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIBBB 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYICCC 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIDDD 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIEEE 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIFFF 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIGGG 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIHHH 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNA 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNB 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNC 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZND 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNE 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNF 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNG 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNH 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR INSR INSR_HUMAN 1I44A 2.4 Inactive DFGin‑None in-out none-out TYR APEdihe_nnoai APEdist_aaai ACP ATPlike 1013 - 1310 0 None C1008S,Y1011F,D1188A Insulin receptor Homo sapiens
TYR INSR INSR_HUMAN 1P14A 1.9 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 1005 - 1310 0 None C1008S,D1159N Insulin receptor Homo sapiens
TYR INSR INSR_HUMAN 4IBMA 1.8 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IR1 Type1 1009 - 1309 0 None K1278N Insulin receptor Homo sapiens
TYR INSR INSR_HUMAN 4IBMB 1.8 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai IR1 Type1 1014 - 1310 0 None K1278N Insulin receptor Homo sapiens
TYR INSR INSR_HUMAN 5E1SA 2.264 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 5JA Type1 1010 - 1310 0 None None Insulin receptor Homo sapiens
TYR INSR INSR_HUMAN 3EKKA 2.1 Inactive DFGin‑None in-out none-none TYR APEdihe_niiai APEdist_aaai GS2 Type1 1007 - 1309 0 None C1008S,D1159N Insulin receptor Homo sapiens
TYR INSR INSR_HUMAN 3EKNA 2.2 Inactive DFGin‑None in-out out-out TYR APEdihe_oiiai APEdist_aaai GS3 Type1 1011 - 1310 0 None C1008S,D1159N Insulin receptor Homo sapiens
TYR INSR INSR_HUMAN 5HHWA 1.79 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 60O Type1.5_Front 1005 - 1310 0 None C1008S,D1159N Insulin receptor Homo sapiens
TYR ITK ITK_HUMAN 3MIYA 1.67 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan B49 Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 3MJ1A 1.72 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 614 Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 4PQNA 1.71 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 2W6 Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 4MF0B 2.67 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 29Z Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 4PPCA 2.95 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VW Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 4PPCB 2.95 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VW Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 3QGWB 2.1 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan L7A Type1 358 - 616 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 1SM2B 2.3 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 1SNUB 2.5 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 3V5JB 2.59 Inactive DFGin‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan 0F2 Type1 357 - 620 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR JAK1-1 JAK1_HUMAN 4L01A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 565 - 850 0 None V658F Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK1-1 JAK1_HUMAN 4L01B 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 565 - 849 0 None V658F Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK1-1 JAK1_HUMAN 4L00A 1.8 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 564 - 850 0 None None Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK1-1 JAK1_HUMAN 4L00B 1.8 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 565 - 850 0 None None Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5I4NA 1.54 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 809 0 None E596A,V617F,W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 4FVRA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None V617F,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 4FVQA 1.75 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8C08A 2.2 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8C08B 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8BA4B 2.1 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 4FVPA 2.01 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8C09A 1.9 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 538 - 809 0 None I559F,W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6G3CA 1.6 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao EKT Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6G3CB 1.6 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao EKT Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6D2IA 3.192 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6D2IB 3.192 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8B8NA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8B8UA 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8B8UB 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 538 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8BA2A 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q9X Type1 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8BA4A 2.1 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao Q8U Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 7F7WA 1.83 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 36H Type1 536 - 810 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 7F7WB 1.83 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 36H Type1 536 - 810 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8B99A 1.6 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8B9EA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8BABA 1.55 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q8N Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8BAKA 1.65 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao AD5 Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8C0AA 1.7 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 809 0 None W659A,R683S,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8C0AB 1.7 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 808 0 None W659A,R683S,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5WIJA 2.04 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5WIKB 2.6 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 584 Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5WILA 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao YDJ Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5WIMA 2.55 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5WINA 2.38 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5USZA 2.103 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5UT0A 2.102 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5UT1A 1.95 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 7DZ Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5UT2A 1.75 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3YT Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5UT3A 1.501 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao IK1 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5UT4A 2.0 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao DQX Type1 537 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5UT5A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 2HB Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5UT6A 1.645 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 8MY Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6BRWA 2.031 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 5BS Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6BS0A 1.541 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao E4V Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6BSSA 2.1 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 4SP Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6M9HA 1.79 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao J9D Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6OAVA 1.939 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao M3A Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6OBBA 1.904 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M3Y Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6OBFA 1.71 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M4G Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6OBLA 2.061 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M4P Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6OCCA 2.03 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M57 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 6XJKA 2.024 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao V4D Type1 539 - 807 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 7JYOA 2.161 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VPS Type1 539 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 7JYQA 1.859 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao VPJ Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 7SZWA 1.906 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao DVY Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 7T0PA 2.04 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E3W Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 7T0PB 2.04 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E3W Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 7T1TA 2.08 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E8I Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8B9HA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8BA3A 1.4 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q8U Type1 536 - 812 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8EX0A 1.85 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8EX1A 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AD5 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8EX2A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao Q2Q Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 9ND5A 2.4 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao A1BXA Type1 536 - 809 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 9ND3A 1.62 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao A1BW6 Type1 536 - 808 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 5TQ3A 2.69 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GZ Type1.5_Back 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 5TQ3B 2.69 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GZ Type1.5_Back 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2 Homo sapiens
TYR KDR VGFR2_HUMAN 1VR2A 2.4 Inactive DFGin‑None in-in none-out TYR APEdihe_iioai APEdist_aaao No_ligand No_ligand 820 - 1168 0 PTR1059 E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR LYN LYN_HUMAN 3A4OX 3.0 Inactive DFGin‑None in-in in-out TYR APEdihe_ooiai APEdist_aaai STU Type1 238 - 505 0 None None Tyrosine-protein kinase Lyn Homo sapiens
TYR MERTK MERTK_HUMAN 5TD2B 2.68 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 577 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 4MH7B 2.51 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 577 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 5TC0B 2.24 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 578 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AB0A 1.74 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 5TD2A 2.68 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan 7AE Type1 577 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7OAMB 2.65 Inactive DFGin‑None none-none none-out TYR APEdihe_nniai APEdist_aaao V6H Type1 576 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 3TCPA 2.69 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan CKJ Type1 577 - 863 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 3TCPB 2.69 Inactive DFGin‑None out-none none-out TYR APEdihe_nniai APEdist_aaao CKJ Type1 576 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 4M3QA 2.718 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan 24K Type1 578 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 4MH7A 2.51 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan MH7 Type1 577 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 4MHAB 2.59 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan 4MH Type1 577 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 5K0KB 2.545 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 6Q1 Type1 577 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 5TC0A 2.24 Inactive DFGin‑None none-none none-none TYR APEdihe_nniai APEdist_aaai 79Y Type1 578 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 5U6CA 2.1 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 7YS Type1 572 - 864 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 5U6CB 2.1 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 7YS Type1 575 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AB1A 1.93 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan C6F Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AB2A 1.78 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan R6N Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AVZA 2.04 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4N Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AW0A 1.893 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4Q Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AW3A 1.99 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4Z Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7M5ZA 3.06 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan YR7 Type1 577 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 6MEPB 2.893 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 9VS Type1.5_Back 578 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MET MET_HUMAN 3EFKA 2.2 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3EFKB 2.2 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 4PMTA 2.1 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 31Y Type1 501 - 787 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5I8AA 2.33 Inactive DFGin‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 69C Type1 501 - 787 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6IQNA 2.54 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai AQ6 Type1 502 - 790 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 7XAFA 3.001 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai FKT Type1 498 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6J5LA 2.3 Inactive DFGin‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai B9C Type1 502 - 790 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6PMEB 3.0 Inactive DFGin‑None in-out out-none TYR APEdihe_niiai APEdist_aaai OOY Type1 499 - 791 0 SEP677 None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 9DAIA 2.864 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai STU Type1 501 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 7VKOA 2.9 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 7GI Type1 502 - 793 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 4AOJB 2.75 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai V4Z Type1 500 - 791 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK2 NTRK2_HUMAN 4AT3A 1.77 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LTI Type1 527 - 822 0 None None BDNF/NT-3 growth factors receptor Homo sapiens
TYR PTK2 FAK1_HUMAN 2IJMA 2.187 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao ATP ATPlike 414 - 688 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 7PI4DDD 2.24 Inactive DFGin‑None in-in out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 415 - 687 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 9SDIB 2.53 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 414 - 685 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 3BZ3A 2.2 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao YAM Type1 414 - 689 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 4GU9A 2.4 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 4GU Type1 414 - 685 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 4KABA 2.71 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 4KA Type1 412 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6I8ZA 1.99 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao H82 Type1 414 - 688 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 4I4EA 1.55 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 1BQ Type1 414 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 4GU6A 1.95 Inactive DFGin‑None in-in out-out TYR APEdihe_iiiai APEdist_aaao 10N Type1 414 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 4GU6B 1.95 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao 10N Type1 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YOJA 1.361 Inactive DFGin‑None in-in out-none TYR APEdihe_nniai APEdist_aaai P4N Type1 414 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YQ1A 1.784 Inactive DFGin‑None in-in out-out TYR APEdihe_niiai APEdist_aaao P7N Type1 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YQ1B 1.784 Inactive DFGin‑None in-in out-out TYR APEdihe_iiiai APEdist_aaao P7N Type1 411 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YQ1C 1.784 Inactive DFGin‑None in-in out-out TYR APEdihe_niiai APEdist_aaao P7N Type1 412 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YQ1D 1.784 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao P7N Type1 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YR9A 1.925 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao P9K Type1 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YR9B 1.925 Inactive DFGin‑None in-in out-out TYR APEdihe_niiai APEdist_aaao P9K Type1 414 - 684 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YR9C 1.925 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao P9K Type1 414 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YR9D 1.925 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao P9K Type1 412 - 685 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YVSB 1.81 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao PVT Type1 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YVSD 1.81 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao PVT Type1 412 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YVYC 1.918 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao P1E Type1 411 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YVYD 1.918 Inactive DFGin‑None in-out none-out TYR APEdihe_niiai APEdist_aaao P1E Type1 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YXVA 2.298 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao Q2H Type1 414 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YXVB 2.298 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao Q2H Type1 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YXVC 2.298 Inactive DFGin‑None in-in out-out TYR APEdihe_iiiai APEdist_aaao Q2H Type1 414 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 6YXVD 2.298 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao Q2H Type1 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2B FAK2_HUMAN 3FZOA 2.2 Inactive DFGin‑None in-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 420 - 691 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 8YGXA 2.0 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 420 - 691 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 3CC6A 1.6 Inactive DFGin‑None in-in out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 415 - 692 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 8XOXA 1.9 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao YAM Type1 417 - 692 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 5TOBA 2.117 Inactive DFGin‑None in-none none-none TYR APEdihe_nnnai APEdist_aaan YAM Type1 420 - 690 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR ROS1 ROS1_HUMAN 7Z5WA 2.254 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao IDW Type1 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
TYR ROS1 ROS1_HUMAN 7Z5WB 2.254 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao IDW Type1 1937 - 2226 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
TYR ROS1 ROS1_HUMAN 7Z5XA 2.035 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao AWJ Type1 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
TYR ROS1 ROS1_HUMAN 7Z5XB 2.035 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao AWJ Type1 1937 - 2226 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
TYR ROS1 ROS1_HUMAN 9QEKA 2.205 Inactive DFGin‑None in-out none-out TYR APEdihe_niiai APEdist_aaao A1I6Z Type1 1934 - 2229 0 None G2032R Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
TYR RYK RYK_HUMAN 6TUAA 2.38 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 298 - 607 0 None None Tyrosine-protein kinase RYK Homo sapiens
TYR SRC SRC_HUMAN 8HAQA 2.27 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan L1N Type1 260 - 536 0 None None Proto-oncogene tyrosine-protein kinase Src Homo sapiens
TYR SRC SRC_HUMAN 8JF3B 2.846 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan C0N Type1 261 - 536 0 None None Proto-oncogene tyrosine-protein kinase Src Homo sapiens
TYR SRC SRC_HUMAN 1YOMB 2.9 Inactive DFGin‑None in-none none-out TYR APEdihe_nnoai APEdist_aaao P01 Type1 258 - 536 0 None S345N,A370S,Y419W Proto-oncogene tyrosine-protein kinase Src Homo sapiens
TYR TNK2 ACK1_HUMAN 8HMTD 3.17 Inactive DFGin‑None in-out in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 5C03A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AGS ATPlike 579 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 5C03B 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AGS ATPlike 580 - 870 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 7AX4A 2.12 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao NM7 Type1 579 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 7AX4B 2.12 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao NM7 Type1 579 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S98A 1.87 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZRU Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S98B 1.87 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZRU Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S98C 1.87 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZRU Type1 578 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S99A 1.71 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZS3 Type1 578 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S99B 1.71 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZS3 Type1 579 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S99C 1.71 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZS3 Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S9AA 1.83 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZSB Type1 577 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S9AB 1.83 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZSB Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8S9AC 1.83 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZSB Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 5TKDA 1.92 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 7GL Type1 581 - 866 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 5TKDB 1.92 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 7GL Type1 581 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 3ZONA 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao IK1 Type1 577 - 870 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZRA 2.56 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LAJ Type1 578 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZRB 2.56 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LAJ Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 4WOVA 1.8 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3SM Type1 580 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 4WOVB 1.8 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3SM Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NSLA 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao KZJ Type1 581 - 866 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NSLB 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao KZJ Type1 581 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZEA 1.96 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L8Y Type1 581 - 863 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZEB 1.96 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L8Y Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZFA 2.39 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L91 Type1 580 - 865 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZFB 2.39 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L91 Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZHA 2.73 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L9A Type1 581 - 866 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZHB 2.73 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao L9A Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZPA 2.35 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LB7 Type1 580 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZPB 2.35 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LB7 Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZQA 2.11 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LB4 Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 6NZQB 2.11 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao LB4 Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 7K7OA 2.82 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VZJ Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 7K7OB 2.82 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VZJ Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 7K7QA 2.27 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VZG Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 7K7QB 2.27 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VZG Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8TB5A 2.32 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZOQ Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8TB5B 2.32 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZOQ Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8TB6A 1.96 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZOI Type1 572 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 8TB6B 1.96 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ZOI Type1 580 - 867 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 5C01A 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao UNL Type1 580 - 868 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 5C01B 2.15 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao UNL Type1 579 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-2 TYK2_HUMAN 4GIIA 2.31 Inactive DFGin‑None in-in in-out TYR APEdihe_oiiai APEdist_aaai 0X6 Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TKL LYR4 G7K7K0_MEDTR 8PS7A 2.1 Pseudo DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ANP ATPlike 340 - 636 0 None None LysM-domain receptor-like kinase Medicago truncatula
OTHER BUD32 KAE1B_METJA 2VWBA 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 530 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 2VWBB 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 532 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3EN9A 2.67 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR Allosteric 1 - 534 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3EN9B 2.67 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR Allosteric 1 - 529 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3ENHA 3.6 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR, TBR, TBR Allosteric, Allosteric, Allosteric 1 - 534 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3ENHB 3.6 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR, TBR, TBR, TBR Allosteric, Allosteric, Allosteric, Allosteric 1 - 529 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 8UP5B 3.56 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 345 - 533 0 None E478R Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
AGC PRKACA KAPCA_MOUSE 4NTTA 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1SYKA 2.8 Inactive DFGin‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 2 - 351 0 TPO198,SEP339 E231Q cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1SYKB 2.8 Inactive DFGin‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 14 - 351 0 TPO198,SEP339 E231Q cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A 1.8 Inactive DFGin‑None none-none out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 47 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ5A 1.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK5 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ6A 1.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK6 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK RPS6KA3-2 KS6A3_MOUSE 4MAOA 2.6 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_oooo 28D Type1 415 - 712 0 None T493M,K591E Ribosomal protein S6 kinase alpha-3 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SOUA 1.5 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnno LPZ, LPZ Allosteric, Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 3TG1A 2.71 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2GHMA 2.35 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo LIC Type1 5 - 352 0 None T180A,Y182F Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 1YW2A 2.01 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnno PGJ Type1 4 - 353 0 None T180A,Y182F Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2GTMA 1.9 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nioo LID Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2GTNA 1.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno LIE Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8ACOAAA 2.65 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9UA 1.67 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnno JMM Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8EFJA 2.31 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo WHQ Type1 5 - 360 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8VMHA 2.46 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo A1ACT Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8VMMA 2.4 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo A1ACP Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8VT6A 2.31 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo WHQ Type1 5 - 360 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8VWMA 1.94 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo WHE Type1 5 - 360 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2EWAA 2.1 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6YCUA 1.35 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno SB4, OKZ Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
OTHER EIF2AK3 E2AK3_MOUSE 3QD2B 2.81 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aanoo APEdist_iiin No_ligand No_ligand 582 - 1078 0 TPO980 None Eukaryotic translation initiation factor 2-alpha kinase 3 Mus musculus
STE STK39 STK39_MOUSE 5DBXA 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 365 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXB 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 364 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
TKL RIPK3 RIPK3_MOUSE 9IWYB 2.52 Inactive DFGin‑None in-none none-none nonTYR APEdihe_aannn APEdist_nnnn A1D97 Type1 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LFVB 2.78 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn A1EJP Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LFVC 2.78 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aannn APEdist_nnnn A1EJP Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LFVD 2.78 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aanni APEdist_nnnn A1EJP Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LFVA 2.78 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnno A1EJO, A1EJP Type1, Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TYR EPHA4 EPHA4_MOUSE 2Y6MA 1.7 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 609 - 891 0 None None Ephrin type-A receptor 4 Mus musculus
TYR EPHA4 EPHA4_MOUSE 2Y6OA 1.543 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 1N1 Type1 609 - 891 0 None None Ephrin type-A receptor 4 Mus musculus
TYR EPHA4 EPHA4_MOUSE 2XYUA 2.117 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai Q9G Type1.5_Back 612 - 891 0 None None Ephrin type-A receptor 4 Mus musculus
TYR EPHB2 EPHB2_MOUSE 1JPAA 1.91 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 594 - 892 0 None Y596F,Y602F Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 1JPAB 1.91 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 594 - 891 0 None Y596F,Y602F Ephrin type-B receptor 2 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FA 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FB 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
OTHER PKNB PKNB_MYCTU 2FUMC 2.89 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn MIX Type1 3 - 278 0 None None Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNF PKNF_MYCTU 7NAAA 2.75 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoi APEdist_nnnn V17 Type1 3 - 278 0 None None Serine/threonine-protein kinase PknF Mycobacterium tuberculosis
OTHER PKNF PKNF_MYCTU 7NAAB 2.75 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaini APEdist_nnno V17 Type1 3 - 278 0 None None Serine/threonine-protein kinase PknF Mycobacterium tuberculosis
OTHER PKNF PKNF_MYCTU 7NAAC 2.75 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoi APEdist_nnnn V17 Type1 24 - 278 0 None None Serine/threonine-protein kinase PknF Mycobacterium tuberculosis
OTHER PKNF PKNF_MYCTU 7NAAD 2.75 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoi APEdist_nnnn V17 Type1 4 - 277 0 None None Serine/threonine-protein kinase PknF Mycobacterium tuberculosis
OTHER PAN3 PAN3_NEUCR 4BWKA 3.3 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 235 - 646 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWKB 3.3 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 235 - 646 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4CZYB 3.4 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 234 - 645 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4CZYD 3.4 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 234 - 645 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWXA 2.85 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 234 - 646 0 None L510M,G511P,G512M,T514G,T515A,H516R,L517F PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWXB 2.85 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 234 - 646 0 None L510M,G511P,G512M,T514G,T515A,H516R,L517F PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PINK1 PINK1_PEDHC 7T3XA 3.53 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 119 - 573 0 None D334A Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
CMGC PK6 Q8IDW1_PLAF7 9CMZA 2.45 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AZE Type1 4 - 294 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CMGC PK6 Q8IDW1_PLAF7 9CMZB 2.45 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AZE Type1 4 - 296 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CMGC PK6 Q8IDW1_PLAF7 9CMZC 2.45 Inactive DFGin‑None in-none in-in nonTYR APEdihe_aaiii APEdist_iiii A1AZE Type1 4 - 295 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CMGC PK6 Q8IDW1_PLAF7 8U2OA 2.15 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V3O Type1 1 - 298 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CMGC PK6 Q8IDW1_PLAF7 8U2OB 2.15 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii V3O Type1 4 - 294 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CAMK CAMK1 KCC1A_RAT 1A06A 2.5 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 10 - 316 0 None None Calcium/calmodulin-dependent protein kinase type 1 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2R0IA 2.202 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None E318A Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2R0IB 2.202 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None E318A Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2WZJA 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2WZJB 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2WZJE 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2WZJF 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4CFHA 3.24 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiio APEdist_iiio STU Type1 21 - 481 0 TPO183,TPO388 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 5KQ5A 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 6VT Type1, Allosteric 21 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 6FJZA 1.864 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_oiii DKW Type1 9 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CAMK RAD53 RAD53_YEAST 5XZVA 3.1 Inactive DFGin‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 16 - 465 0 None None Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CAMK SNF1 SNF1_YEAST 3HYHA 2.2 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 54 - 315 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
CAMK SNF1 SNF1_YEAST 3HYHB 2.2 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 54 - 315 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
CAMK SNF1 SNF1_YEAST 3DAEA 2.899 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 48 - 315 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
CAMK SNF1 SNF1_YEAST 3DAEB 2.899 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 50 - 315 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7B 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 226 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7E 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 252 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7F 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 228 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7H 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 250 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7I 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 229 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7K 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 232 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7L 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 228 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 6R5KN 4.8 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 226 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 6R5KO 4.8 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 224 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PINK1 PINK1_TRICA 7MP9A 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiai APEdist_iiii AN2 ATPlike 121 - 568 0 SEP205,TPO530 None Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum
OTHER PINK1 PINK1_TRICA 8UDCA 3.1 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaoai APEdist_iiii WCK Type1 122 - 566 0 None W131A,W142A,Y144A,I147A,Y225A,Y378A,F401A,F437A Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum
OTHER PINK1 PINK1_TRICA 8UCTA 2.93 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiai APEdist_iiii 3YT Type1 122 - 566 0 None W131A,W142A,Y225A,Y378A,F401A,F437A Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum
AGC TB0348O8470 Q582V7_TRYB2 9Z8KA 2.05 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 54 - 348 0 SEP71 None Serine/threonine-protein kinase, putative Trypanosoma brucei brucei
CAMK AURKBA AUKBA_XENLA 4B8LA 3.0 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn A0P Type1 87 - 351 0 None P353G Aurora kinase B-A Xenopus laevis

All / DFGinNone / All

Total number of chains: 182
Active chains: 0
Total number of genes: 39
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 182 100.0% 6FJZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CAMK SRK2E SRK2E_ARATH 3ZUTA 2.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 10 - 319 0 None D160A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3ZUTB 2.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 319 0 None D160A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3ZUUA 2.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 10 - 319 0 None None Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3ZUUB 2.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 319 0 None None Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2I SRK2I_ARATH 3UC3A 1.9 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 11 - 319 0 None D57A,K58A Serine/threonine-protein kinase SRK2I Arabidopsis thaliana
CMGC MPK6 MPK6_ARATH 6DTLB 2.753 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 33 - 395 0 None None Mitogen-activated protein kinase 6 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRB 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 65 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRE 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 65 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRG 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 64 - 327 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
TKL BAK1 BAK1_ARATH 3TL8G 2.5 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 274 - 578 0 TPO324,TPO446,TPO449,TPO450 None BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 Arabidopsis thaliana
TKL BIK1 BIK1_ARATH 5TOSA 2.35 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 52 - 360 0 SEP253 None Serine/threonine-protein kinase BIK1 Arabidopsis thaliana
TKL BIK1 BIK1_ARATH 5TOSB 2.35 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 52 - 360 0 SEP253 None Serine/threonine-protein kinase BIK1 Arabidopsis thaliana
TKL CARK1 CARK1_ARATH 5XD6A 1.898 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 50 - 350 0 None None Protein CYTOSOLIC ABA RECEPTOR KINASE 1 Arabidopsis thaliana
TKL CARK1 CARK1_ARATH 5XD6B 1.898 Inactive DFGin‑None out-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 50 - 350 0 None None Protein CYTOSOLIC ABA RECEPTOR KINASE 1 Arabidopsis thaliana
TKL CTR1 CTR1_ARATH 3P86B 2.496 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 543 - 810 0 None D676N Serine/threonine-protein kinase CTR1 Arabidopsis thaliana
AGC GRK2 ARBK1_BOVIN 1OMWA 2.5 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 1YM7A 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 1YM7C 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 1YM7D 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 2BCJA 3.061 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 667 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3UZSA 4.52 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiio APEdist_iiii No_ligand No_ligand 29 - 671 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3UZTA 3.51 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 30 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3PSCA 2.67 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3PVUA 2.48 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRW Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 3PVWA 2.49 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRX Type1 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC PRKACA KAPCA_BOVIN 4C35A 2.19 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NU3 Type1.5_Back 11 - 351 0 SEP11,SEP140,TPO198,SEP339 F55Y,M121L,V124L,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
CMGC CDK7 G0SFC6_CHATD 6Z4XB 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 78 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
CMGC CDK7 G0SFC6_CHATD 6Z4XE 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 77 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIA 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIB 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 213 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIC 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYID 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 214 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIE 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIF 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 213 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIG 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 212 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIH 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJA 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 630 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJB 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJC 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 210 - 632 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJD 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PKNG Q8NM29_CORGL 7MXBA 2.2 Inactive DFGin‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MAP Type1 52 - 728 0 None None non-specific serine/threonine protein kinase Corynebacterium glutamicum
OTHER POMK SG196_DANRE 5GZAA 2.0 Pseudo DFGin‑None none-na in-out nonTYR APEdihe_aaioo APEdist_iioo ADP, ZZ1 ATPlike, Allosteric 53 - 342 0 None None Protein O-mannose kinase Danio rerio
OTHER PAN3 PAN3_DROME 4BWPA 3.6 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AN2 ATPlike 379 - 787 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Drosophila melanogaster
OTHER PAN3 PAN3_DROME 4BWPB 3.6 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AN2 ATPlike 379 - 787 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Drosophila melanogaster
TYR PTK2 FAK1_CHICK 4D4RA 1.55 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 414 - 685 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D4RB 1.55 Inactive DFGin‑None out-out out-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 412 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D4SA 2.0 Inactive DFGin‑None in-in none-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D4YA 1.8 Inactive DFGin‑None in-in none-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D58A 1.95 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 414 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D5KA 1.75 Inactive DFGin‑None in-in none-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6TY3A 6.32 Inactive DFGin‑None in-out out-out TYR APEdihe_iiiai APEdist_aaao No_ligand No_ligand 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6TY3B 6.32 Inactive DFGin‑None in-out out-out TYR APEdihe_iiiai APEdist_aaao No_ligand No_ligand 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2JKMA 2.31 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao BII Type1 413 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2J0MB 2.8 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 4ST Type1 414 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2JKQA 2.6 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai VG8 Type1 414 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2JKKA 2.0 Inactive DFGin‑None in-in out-none TYR APEdihe_nniai APEdist_aaai BI9 Type1 413 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2JKOA 1.65 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai BIJ Type1 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4BRXA 2.05 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao KGW Type1 413 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4C7TA 2.05 Inactive DFGin‑None in-in out-none TYR APEdihe_nniai APEdist_aaai 5RI Type1 414 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 4D5HA 1.75 Inactive DFGin‑None in-out none-out TYR APEdihe_niiai APEdist_aaao 9RM Type1 415 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6GCRA 2.3 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao EUW Type1 413 - 684 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6GCWA 2.0 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao EUQ Type1 414 - 685 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6GCWB 2.0 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao EUQ Type1 414 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6GCXA 1.553 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao EUW Type1 413 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2J0JA 2.8 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao 4ST Type1 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2J0KA 3.0 Inactive DFGin‑None in-in none-out TYR APEdihe_niiai APEdist_aaao 4ST Type1 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 2J0KB 3.0 Inactive DFGin‑None in-in out-out TYR APEdihe_nniai APEdist_aaao 4ST Type1 35 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR SRC SRC_CHICK 2QI8B 2.32 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 258 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3OF0A 2.7 Inactive DFGin‑None in-none none-out TYR APEdihe_nnoai APEdist_aaao No_ligand No_ligand 257 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3OF0B 2.7 Inactive DFGin‑None out-none none-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 257 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EN7B 2.81 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 260 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5D10B 2.7 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan 563 Type1 257 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 6HVFA 2.1 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan GUT Type1 257 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3QLFA 2.75 Inactive DFGin‑None in-none none-out TYR APEdihe_nniai APEdist_aaao PD5 Type1 258 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EN6B 2.39 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnan APEdist_aaan KS5 Type1 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EN7A 2.81 Inactive DFGin‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan ABJ Type1 256 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4O2PA 2.1 Inactive DFGin‑None out-out out-out TYR APEdihe_nniai APEdist_aaao 11V Type1 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 7AH3A 1.95 Inactive DFGin‑None out-out out-none TYR APEdihe_nnnai APEdist_aaan RCK Type1 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 8K79B 2.8 Inactive DFGin‑None in-none out-none TYR APEdihe_nniai APEdist_aaai IYC Type1 269 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4LGGA 2.41 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan VGG Type1 264 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4LGGB 2.41 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan VGG Type1 264 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 2HWOB 2.5 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan RBS Type1 258 - 533 0 None S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 2HWPA 2.48 Inactive DFGin‑None none-none none-none TYR APEdihe_nniai APEdist_aaai DJK Type1 256 - 533 0 None S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4LGHA 2.84 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan 0JN Type1 257 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4LGHB 2.84 Inactive DFGin‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan 0JN Type1 259 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4MCVB 2.73 Inactive DFGin‑None in-none in-out TYR APEdihe_noiai APEdist_aaao 29K Type1 257 - 533 0 None T338G Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5T0PA 2.5 Inactive DFGin‑None in-out in-none TYR APEdihe_nnnai APEdist_aaan 73A Type1 257 - 533 0 None V313C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5T0PB 2.5 Inactive DFGin‑None in-out in-none TYR APEdihe_nnnai APEdist_aaan 73A Type1 258 - 533 0 None V313C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 2QLQA 2.33 Inactive DFGin‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan SR2, SR2 Type1, Allosteric 256 - 533 0 None S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5TEHA 2.99 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao S56 Type1.5_Back 256 - 533 0 None V281C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3QLFB 2.75 Inactive DFGin‑None out-none in-out TYR APEdihe_nniai APEdist_aaao PD5 Type1.5_Front 258 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TKL LYR4 G7K7K0_MEDTR 8PS7A 2.1 Pseudo DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ANP ATPlike 340 - 636 0 None None LysM-domain receptor-like kinase Medicago truncatula
OTHER BUD32 KAE1B_METJA 2VWBA 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 530 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 2VWBB 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 532 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3EN9A 2.67 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR Allosteric 1 - 534 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3EN9B 2.67 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR Allosteric 1 - 529 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3ENHA 3.6 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR, TBR, TBR Allosteric, Allosteric, Allosteric 1 - 534 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3ENHB 3.6 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR, TBR, TBR, TBR Allosteric, Allosteric, Allosteric, Allosteric 1 - 529 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 8UP5B 3.56 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 345 - 533 0 None E478R Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
AGC PRKACA KAPCA_MOUSE 4NTTA 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1SYKA 2.8 Inactive DFGin‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 2 - 351 0 TPO198,SEP339 E231Q cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1SYKB 2.8 Inactive DFGin‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 14 - 351 0 TPO198,SEP339 E231Q cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A 1.8 Inactive DFGin‑None none-none out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 47 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ5A 1.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK5 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ6A 1.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK6 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK RPS6KA3-2 KS6A3_MOUSE 4MAOA 2.6 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_oooo 28D Type1 415 - 712 0 None T493M,K591E Ribosomal protein S6 kinase alpha-3 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SOUA 1.5 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnno LPZ, LPZ Allosteric, Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 3TG1A 2.71 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2GHMA 2.35 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo LIC Type1 5 - 352 0 None T180A,Y182F Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 1YW2A 2.01 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnno PGJ Type1 4 - 353 0 None T180A,Y182F Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2GTMA 1.9 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nioo LID Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2GTNA 1.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno LIE Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8ACOAAA 2.65 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9UA 1.67 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnno JMM Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8EFJA 2.31 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo WHQ Type1 5 - 360 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8VMHA 2.46 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo A1ACT Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8VMMA 2.4 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo A1ACP Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8VT6A 2.31 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo WHQ Type1 5 - 360 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8VWMA 1.94 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo WHE Type1 5 - 360 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2EWAA 2.1 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6YCUA 1.35 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno SB4, OKZ Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
OTHER EIF2AK3 E2AK3_MOUSE 3QD2B 2.81 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aanoo APEdist_iiin No_ligand No_ligand 582 - 1078 0 TPO980 None Eukaryotic translation initiation factor 2-alpha kinase 3 Mus musculus
STE STK39 STK39_MOUSE 5DBXA 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 365 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXB 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 364 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
TKL RIPK3 RIPK3_MOUSE 9IWYB 2.52 Inactive DFGin‑None in-none none-none nonTYR APEdihe_aannn APEdist_nnnn A1D97 Type1 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LFVB 2.78 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn A1EJP Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LFVC 2.78 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aannn APEdist_nnnn A1EJP Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LFVD 2.78 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aanni APEdist_nnnn A1EJP Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LFVA 2.78 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnno A1EJO, A1EJP Type1, Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TYR EPHA4 EPHA4_MOUSE 2Y6MA 1.7 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 609 - 891 0 None None Ephrin type-A receptor 4 Mus musculus
TYR EPHA4 EPHA4_MOUSE 2Y6OA 1.543 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 1N1 Type1 609 - 891 0 None None Ephrin type-A receptor 4 Mus musculus
TYR EPHA4 EPHA4_MOUSE 2XYUA 2.117 Inactive DFGin‑None in-out none-none TYR APEdihe_nniai APEdist_aaai Q9G Type1.5_Back 612 - 891 0 None None Ephrin type-A receptor 4 Mus musculus
TYR EPHB2 EPHB2_MOUSE 1JPAA 1.91 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 594 - 892 0 None Y596F,Y602F Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 1JPAB 1.91 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 594 - 891 0 None Y596F,Y602F Ephrin type-B receptor 2 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FA 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FB 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
OTHER PKNB PKNB_MYCTU 2FUMC 2.89 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn MIX Type1 3 - 278 0 None None Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNF PKNF_MYCTU 7NAAA 2.75 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoi APEdist_nnnn V17 Type1 3 - 278 0 None None Serine/threonine-protein kinase PknF Mycobacterium tuberculosis
OTHER PKNF PKNF_MYCTU 7NAAB 2.75 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaini APEdist_nnno V17 Type1 3 - 278 0 None None Serine/threonine-protein kinase PknF Mycobacterium tuberculosis
OTHER PKNF PKNF_MYCTU 7NAAC 2.75 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoi APEdist_nnnn V17 Type1 24 - 278 0 None None Serine/threonine-protein kinase PknF Mycobacterium tuberculosis
OTHER PKNF PKNF_MYCTU 7NAAD 2.75 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoi APEdist_nnnn V17 Type1 4 - 277 0 None None Serine/threonine-protein kinase PknF Mycobacterium tuberculosis
OTHER PAN3 PAN3_NEUCR 4BWKA 3.3 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 235 - 646 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWKB 3.3 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 235 - 646 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4CZYB 3.4 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 234 - 645 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4CZYD 3.4 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 234 - 645 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWXA 2.85 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 234 - 646 0 None L510M,G511P,G512M,T514G,T515A,H516R,L517F PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWXB 2.85 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 234 - 646 0 None L510M,G511P,G512M,T514G,T515A,H516R,L517F PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PINK1 PINK1_PEDHC 7T3XA 3.53 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 119 - 573 0 None D334A Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
CMGC PK6 Q8IDW1_PLAF7 9CMZA 2.45 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AZE Type1 4 - 294 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CMGC PK6 Q8IDW1_PLAF7 9CMZB 2.45 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AZE Type1 4 - 296 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CMGC PK6 Q8IDW1_PLAF7 9CMZC 2.45 Inactive DFGin‑None in-none in-in nonTYR APEdihe_aaiii APEdist_iiii A1AZE Type1 4 - 295 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CMGC PK6 Q8IDW1_PLAF7 8U2OA 2.15 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V3O Type1 1 - 298 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CMGC PK6 Q8IDW1_PLAF7 8U2OB 2.15 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii V3O Type1 4 - 294 0 None C44N,C53R,K86A,C222N,K237A Cyclin-dependent kinase 2 homolog Plasmodium falciparum
CAMK CAMK1 KCC1A_RAT 1A06A 2.5 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 10 - 316 0 None None Calcium/calmodulin-dependent protein kinase type 1 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2R0IA 2.202 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None E318A Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2R0IB 2.202 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None E318A Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2WZJA 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2WZJB 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2WZJE 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK MARK2 MARK2_RAT 2WZJF 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4CFHA 3.24 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiio APEdist_iiio STU Type1 21 - 481 0 TPO183,TPO388 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 5KQ5A 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 6VT Type1, Allosteric 21 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 6FJZA 1.864 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_oiii DKW Type1 9 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CAMK RAD53 RAD53_YEAST 5XZVA 3.1 Inactive DFGin‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 16 - 465 0 None None Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CAMK SNF1 SNF1_YEAST 3HYHA 2.2 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 54 - 315 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
CAMK SNF1 SNF1_YEAST 3HYHB 2.2 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 54 - 315 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
CAMK SNF1 SNF1_YEAST 3DAEA 2.899 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 48 - 315 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
CAMK SNF1 SNF1_YEAST 3DAEB 2.899 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 50 - 315 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7B 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 226 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7E 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 252 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7F 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 228 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7H 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 250 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7I 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 229 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7K 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 232 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 4XR7L 3.796 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 228 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 6R5KN 4.8 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 226 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PAN3-12 PAN3_YEAST 6R5KO 4.8 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa No_ligand No_ligand 224 - 679 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Saccharomyces cerevisiae
OTHER PINK1 PINK1_TRICA 7MP9A 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiai APEdist_iiii AN2 ATPlike 121 - 568 0 SEP205,TPO530 None Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum
OTHER PINK1 PINK1_TRICA 8UDCA 3.1 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaoai APEdist_iiii WCK Type1 122 - 566 0 None W131A,W142A,Y144A,I147A,Y225A,Y378A,F401A,F437A Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum
OTHER PINK1 PINK1_TRICA 8UCTA 2.93 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiai APEdist_iiii 3YT Type1 122 - 566 0 None W131A,W142A,Y225A,Y378A,F401A,F437A Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum
AGC TB0348O8470 Q582V7_TRYB2 9Z8KA 2.05 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 54 - 348 0 SEP71 None Serine/threonine-protein kinase, putative Trypanosoma brucei brucei
CAMK AURKBA AUKBA_XENLA 4B8LA 3.0 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn A0P Type1 87 - 351 0 None P353G Aurora kinase B-A Xenopus laevis