Protein kinases in complex with I74 (Samuraciclib)

Total number of genes: 2
Total number of chains: 6
Spatial Dihedral Chains Representative
DFGin BLAminus 4 7B5OJ
DFGin None 1 8RU8A
None None 1 5JQ5A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 8RU8A 1.51 Inactive DFGin None out-out none-out I74 Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 5JQ5A 1.94 Inactive None None out-out out-out I74 Type1
CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 8R9AA 1.71 Active DFGin BLAminus in-in in-in I74 Type1
CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 8P6VJ 1.9 Active DFGin BLAminus in-in in-in I74 Type1
CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 7B5OJ 2.5 Active DFGin BLAminus in-in in-in I74 Type1
CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 7B5QJ 2.5 Active DFGin BLAminus in-in in-in I74 Type1

Protein kinases in complex with I74

Total number of genes: 2
Total number of chains: 6
Spatial Dihedral Chains Representative
DFGin BLAminus 4 7B5OJ
DFGin None 1 8RU8A
None None 1 5JQ5A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 8RU8A 1.51 Inactive DFGin None out-out none-out I74 Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 5JQ5A 1.94 Inactive None None out-out out-out I74 Type1
Homo sapiens CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 8R9AA 1.71 Active DFGin BLAminus in-in in-in I74 Type1
Homo sapiens CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 8P6VJ 1.9 Active DFGin BLAminus in-in in-in I74 Type1
Homo sapiens CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 7B5OJ 2.5 Active DFGin BLAminus in-in in-in I74 Type1
Homo sapiens CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 7B5QJ 2.5 Active DFGin BLAminus in-in in-in I74 Type1

Protein kinases in complex with I74

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type