CHEK2 (Serine/threonine-protein kinase Chk2)

Group: CAMK
Uniprot: CHK2_HUMAN
Domain boundary: 220 - 486


Total number of chains: 45
Spatial Dihedral Chains Representative
DFGin BLAminus 39 AF-O96017-K1A
DFGin BLAplus 1 3I6UA
DFGin None 5 3I6UB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-O96017-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 212 - 494 None None 0
3I6WB 3.25 None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 K249R None 5
3I6WD 3.25 None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 K249R None 5
3I6WF 3.25 None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 K249R None 5
3I6WH 3.25 None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 K249R None 5
2XK9A 2.35 Inactive DFGin BLAminus out-out in-out XK9 Type1 211 - 510 None None 0
2YCFA 1.77 Inactive DFGin BLAminus in-out in-out YCF Type1 210 - 510 None None 0
2W0JA 2.05 Inactive DFGin BLAminus out-out in-out ZAT Type1 210 - 510 None None 2
2W7XA 2.07 Inactive DFGin BLAminus out-out in-out D1A Type1 210 - 510 None None 0
2YCQA 2.05 Inactive DFGin BLAminus out-out in-out UPX Type1 211 - 510 None None 0
2YCSA 2.35 Inactive DFGin BLAminus out-out in-out NXP Type1 210 - 510 None None 2
2YIQA 1.89 Inactive DFGin BLAminus out-out in-out YIQ Type1 211 - 510 None None 0
2YIRA 2.1 Inactive DFGin BLAminus out-out in-out YIR Type1 210 - 509 None None 0
2YCRA 2.2 Inactive DFGin BLAminus out-out in-out HCW Type1 211 - 510 None None 0
2CN5A 2.25 Inactive DFGin BLAminus in-out in-out ADP Type1 209 - 504 None None 0
2CN8A 2.7 None DFGin BLAminus in-out in-none DBQ Type1 212 - 503 None None 4
2WTCA 3.0 Inactive DFGin BLAminus in-in in-out VGM Type1 211 - 512 None None 2
2WTDA 2.75 Inactive DFGin BLAminus in-in in-out ZZK Type1 210 - 512 None None 2
2WTIA 2.5 Inactive DFGin BLAminus in-in in-out WTI Type1 210 - 512 None None 1
2WTJA 2.1 Inactive DFGin BLAminus in-in in-out WTJ Type1 209 - 512 None None 1
2XBJA 2.3 Inactive DFGin BLAminus in-out in-out XBJ Type1 211 - 512 None None 2
2XM8A 3.4 None DFGin BLAminus in-none in-out B4W Type1 211 - 503 None None 5
2XM9A 2.5 Inactive DFGin BLAminus in-in in-out LWH Type1 211 - 512 None None 0
4A9RA 2.85 Inactive DFGin BLAminus in-in in-out RU5 Type1 210 - 513 None None 0
4A9SA 2.66 Inactive DFGin BLAminus in-in in-out RU9 Type1 211 - 513 None None 2
4A9TA 2.7 Inactive DFGin BLAminus in-in in-out A9T Type1 210 - 513 None None 0
4A9UA 2.48 Inactive DFGin BLAminus in-in in-out A9U Type1 210 - 513 None None 2
4BDAA 2.6 Inactive DFGin BLAminus in-in in-out VFB Type1 210 - 512 None None 1
4BDBA 2.5 None DFGin BLAminus out-none in-out ODO Type1 210 - 513 None None 1
4BDCA 3.0 None DFGin BLAminus in-none in-out ODH Type1 210 - 512 None None 1
4BDDA 2.67 None DFGin BLAminus out-none in-out Z0O Type1 210 - 512 None None 2
4BDEA 2.55 None DFGin BLAminus in-none in-out CWS Type1 210 - 513 None None 2
4BDFA 2.7 None DFGin BLAminus in-none in-out H3R Type1 210 - 512 None None 0
4BDGA 2.84 None DFGin BLAminus in-none in-out P3J Type1 210 - 512 None None 0
4BDHA 2.7 None DFGin BLAminus in-none in-out WVI Type1 210 - 513 None None 0
4BDIA 2.32 None DFGin BLAminus in-none in-out HAU Type1 210 - 515 None None 0
4BDJA 3.01 None DFGin BLAminus in-none in-out Z2M Type1 211 - 513 None None 1
4BDKA 3.3 None DFGin BLAminus in-none in-out RQQ Type1 211 - 513 None None 0
2YITA 2.2 Inactive DFGin BLAminus out-out in-out YIT Type1.5_Back 211 - 510 None None 0
3I6UA 3.0 Inactive DFGin BLAplus out-none out-none No_ligand No_ligand 89 - 501 K249R None 11
3I6UB 3.0 Inactive DFGin None out-none none-none No_ligand No_ligand 89 - 501 K249R None 18
3I6WA 3.25 Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 K249R None 18
3I6WC 3.25 Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 K249R None 18
3I6WE 3.25 Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 K249R None 18
3I6WG 3.25 Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 K249R None 18

CHEK2 (Serine/threonine-protein kinase Chk2)

Group: CAMK
Total number of chains: 45
Spatial Dihedral Chains Representative
DFGin BLAminus 39 AF-O96017-K1A
DFGin BLAplus 1 3I6UA
DFGin None 5 3I6UB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CHK2_HUMAN AF-O96017-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 212 - 494 None None 0
Homo sapiens CHK2_HUMAN 3I6WB 3.25 None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 K249R None 5
Homo sapiens CHK2_HUMAN 3I6WD 3.25 None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 K249R None 5
Homo sapiens CHK2_HUMAN 3I6WF 3.25 None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 K249R None 5
Homo sapiens CHK2_HUMAN 3I6WH 3.25 None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 K249R None 5
Homo sapiens CHK2_HUMAN 2XK9A 2.35 Inactive DFGin BLAminus out-out in-out XK9 Type1 211 - 510 None None 0
Homo sapiens CHK2_HUMAN 2YCFA 1.77 Inactive DFGin BLAminus in-out in-out YCF Type1 210 - 510 None None 0
Homo sapiens CHK2_HUMAN 2W0JA 2.05 Inactive DFGin BLAminus out-out in-out ZAT Type1 210 - 510 None None 2
Homo sapiens CHK2_HUMAN 2W7XA 2.07 Inactive DFGin BLAminus out-out in-out D1A Type1 210 - 510 None None 0
Homo sapiens CHK2_HUMAN 2YCQA 2.05 Inactive DFGin BLAminus out-out in-out UPX Type1 211 - 510 None None 0
Homo sapiens CHK2_HUMAN 2YCSA 2.35 Inactive DFGin BLAminus out-out in-out NXP Type1 210 - 510 None None 2
Homo sapiens CHK2_HUMAN 2YIQA 1.89 Inactive DFGin BLAminus out-out in-out YIQ Type1 211 - 510 None None 0
Homo sapiens CHK2_HUMAN 2YIRA 2.1 Inactive DFGin BLAminus out-out in-out YIR Type1 210 - 509 None None 0
Homo sapiens CHK2_HUMAN 2YCRA 2.2 Inactive DFGin BLAminus out-out in-out HCW Type1 211 - 510 None None 0
Homo sapiens CHK2_HUMAN 2CN5A 2.25 Inactive DFGin BLAminus in-out in-out ADP Type1 209 - 504 None None 0
Homo sapiens CHK2_HUMAN 2CN8A 2.7 None DFGin BLAminus in-out in-none DBQ Type1 212 - 503 None None 4
Homo sapiens CHK2_HUMAN 2WTCA 3.0 Inactive DFGin BLAminus in-in in-out VGM Type1 211 - 512 None None 2
Homo sapiens CHK2_HUMAN 2WTDA 2.75 Inactive DFGin BLAminus in-in in-out ZZK Type1 210 - 512 None None 2
Homo sapiens CHK2_HUMAN 2WTIA 2.5 Inactive DFGin BLAminus in-in in-out WTI Type1 210 - 512 None None 1
Homo sapiens CHK2_HUMAN 2WTJA 2.1 Inactive DFGin BLAminus in-in in-out WTJ Type1 209 - 512 None None 1
Homo sapiens CHK2_HUMAN 2XBJA 2.3 Inactive DFGin BLAminus in-out in-out XBJ Type1 211 - 512 None None 2
Homo sapiens CHK2_HUMAN 2XM8A 3.4 None DFGin BLAminus in-none in-out B4W Type1 211 - 503 None None 5
Homo sapiens CHK2_HUMAN 2XM9A 2.5 Inactive DFGin BLAminus in-in in-out LWH Type1 211 - 512 None None 0
Homo sapiens CHK2_HUMAN 4A9RA 2.85 Inactive DFGin BLAminus in-in in-out RU5 Type1 210 - 513 None None 0
Homo sapiens CHK2_HUMAN 4A9SA 2.66 Inactive DFGin BLAminus in-in in-out RU9 Type1 211 - 513 None None 2
Homo sapiens CHK2_HUMAN 4A9TA 2.7 Inactive DFGin BLAminus in-in in-out A9T Type1 210 - 513 None None 0
Homo sapiens CHK2_HUMAN 4A9UA 2.48 Inactive DFGin BLAminus in-in in-out A9U Type1 210 - 513 None None 2
Homo sapiens CHK2_HUMAN 4BDAA 2.6 Inactive DFGin BLAminus in-in in-out VFB Type1 210 - 512 None None 1
Homo sapiens CHK2_HUMAN 4BDBA 2.5 None DFGin BLAminus out-none in-out ODO Type1 210 - 513 None None 1
Homo sapiens CHK2_HUMAN 4BDCA 3.0 None DFGin BLAminus in-none in-out ODH Type1 210 - 512 None None 1
Homo sapiens CHK2_HUMAN 4BDDA 2.67 None DFGin BLAminus out-none in-out Z0O Type1 210 - 512 None None 2
Homo sapiens CHK2_HUMAN 4BDEA 2.55 None DFGin BLAminus in-none in-out CWS Type1 210 - 513 None None 2
Homo sapiens CHK2_HUMAN 4BDFA 2.7 None DFGin BLAminus in-none in-out H3R Type1 210 - 512 None None 0
Homo sapiens CHK2_HUMAN 4BDGA 2.84 None DFGin BLAminus in-none in-out P3J Type1 210 - 512 None None 0
Homo sapiens CHK2_HUMAN 4BDHA 2.7 None DFGin BLAminus in-none in-out WVI Type1 210 - 513 None None 0
Homo sapiens CHK2_HUMAN 4BDIA 2.32 None DFGin BLAminus in-none in-out HAU Type1 210 - 515 None None 0
Homo sapiens CHK2_HUMAN 4BDJA 3.01 None DFGin BLAminus in-none in-out Z2M Type1 211 - 513 None None 1
Homo sapiens CHK2_HUMAN 4BDKA 3.3 None DFGin BLAminus in-none in-out RQQ Type1 211 - 513 None None 0
Homo sapiens CHK2_HUMAN 2YITA 2.2 Inactive DFGin BLAminus out-out in-out YIT Type1.5_Back 211 - 510 None None 0
Homo sapiens CHK2_HUMAN 3I6UA 3.0 Inactive DFGin BLAplus out-none out-none No_ligand No_ligand 89 - 501 K249R None 11
Homo sapiens CHK2_HUMAN 3I6UB 3.0 Inactive DFGin None out-none none-none No_ligand No_ligand 89 - 501 K249R None 18
Homo sapiens CHK2_HUMAN 3I6WA 3.25 Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 K249R None 18
Homo sapiens CHK2_HUMAN 3I6WC 3.25 Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 K249R None 18
Homo sapiens CHK2_HUMAN 3I6WE 3.25 Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 K249R None 18
Homo sapiens CHK2_HUMAN 3I6WG 3.25 Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 K249R None 18

CHEK2 (Serine/threonine-protein kinase Chk2)

No non-human structures known.