MAPK6 (Mitogen-activated protein kinase 6)

Group: CMGC

Uniprot: MK06_HUMAN

Domain boundary: 20 - 316

Total number of chains: 13

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	8	AF-Q16659-K1A
DFGin	None	1	7AQBB
DFGinter	None	3	6YLCD
DFGout	None	1	6YLCA

Database table as tsv

PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
6YLLB	2.89	None	DFGin	BLAminus	out-out	none-out	No_ligand	No_ligand	46 - 321	L290V	None	13
7AQBA	2.25	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	13 - 320	None	None	7
AF-Q16659-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	12 - 324	None	None	0
6YKYB	2.52	Inactive	DFGin	BLAminus	in-in	in-out	OWQ	Type1	16 - 321	L290V	None	6
6YKYC	2.52	Inactive	DFGin	BLAminus	in-in	in-out	OWQ	Type1	13 - 319	L290V	None	9
6YLCB	2.43	Inactive	DFGin	BLAminus	in-in	in-out	OXW	Type1	16 - 321	L290V	None	6
6YLCC	2.43	None	DFGin	BLAminus	in-in	none-out	OXW	Type1	14 - 319	L290V	None	14
6YLLA	2.89	Inactive	DFGin	BLAminus	out-in	in-out	OYB	Type1	14 - 321	L290V	None	8
7AQBB	2.25	Inactive	DFGin	None	out-none	none-out	No_ligand	No_ligand	21 - 320	None	None	14
6YKYA	2.52	Inactive	DFGinter	None	in-out	out-out	OWQ	Type1	18 - 319	L290V	None	9
6YKYD	2.52	Inactive	DFGinter	None	out-out	out-out	OWQ	Type1	14 - 321	L290V	None	0
6YLCD	2.43	Inactive	DFGinter	None	out-out	out-out	OXW	Type1	13 - 321	L290V	None	0
6YLCA	2.43	Inactive	DFGout	None	in-out	out-out	OXW	Type1	15 - 320	L290V	None	9

MAPK6 (Mitogen-activated protein kinase 6)

Group: CMGC

Total number of chains: 13

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	8	AF-Q16659-K1A
DFGin	None	1	7AQBB
DFGinter	None	3	6YLCD
DFGout	None	1	6YLCA

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Homo sapiens	MK06_HUMAN	6YLLB	2.89	None	DFGin	BLAminus	out-out	none-out	No_ligand	No_ligand	46 - 321	L290V	None	13
Homo sapiens	MK06_HUMAN	7AQBA	2.25	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	13 - 320	None	None	7
Homo sapiens	MK06_HUMAN	AF-Q16659-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	12 - 324	None	None	0
Homo sapiens	MK06_HUMAN	6YKYB	2.52	Inactive	DFGin	BLAminus	in-in	in-out	OWQ	Type1	16 - 321	L290V	None	6
Homo sapiens	MK06_HUMAN	6YKYC	2.52	Inactive	DFGin	BLAminus	in-in	in-out	OWQ	Type1	13 - 319	L290V	None	9
Homo sapiens	MK06_HUMAN	6YLCB	2.43	Inactive	DFGin	BLAminus	in-in	in-out	OXW	Type1	16 - 321	L290V	None	6
Homo sapiens	MK06_HUMAN	6YLCC	2.43	None	DFGin	BLAminus	in-in	none-out	OXW	Type1	14 - 319	L290V	None	14
Homo sapiens	MK06_HUMAN	6YLLA	2.89	Inactive	DFGin	BLAminus	out-in	in-out	OYB	Type1	14 - 321	L290V	None	8
Homo sapiens	MK06_HUMAN	7AQBB	2.25	Inactive	DFGin	None	out-none	none-out	No_ligand	No_ligand	21 - 320	None	None	14
Homo sapiens	MK06_HUMAN	6YKYA	2.52	Inactive	DFGinter	None	in-out	out-out	OWQ	Type1	18 - 319	L290V	None	9
Homo sapiens	MK06_HUMAN	6YKYD	2.52	Inactive	DFGinter	None	out-out	out-out	OWQ	Type1	14 - 321	L290V	None	0
Homo sapiens	MK06_HUMAN	6YLCD	2.43	Inactive	DFGinter	None	out-out	out-out	OXW	Type1	13 - 321	L290V	None	0
Homo sapiens	MK06_HUMAN	6YLCA	2.43	Inactive	DFGout	None	in-out	out-out	OXW	Type1	15 - 320	L290V	None	9

MAPK6 (Mitogen-activated protein kinase 6)

No non-human structures known.