CAMK_AURKA (Aurora kinase A)

Total number of chains: 235
Active chains: 7
Family: CAMK
Uniprot: AURKA_HUMAN
Kinase Domain Residues: 133 - 383
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 103 43.8% AF-O14965-K1A
DFGinter None 67 28.5% 5L8LA
DFGin None 19 8.1% 2J4ZB
DFGin ABAminus 18 7.7% 3E5AA
None None 18 7.7% 5OBRA
DFGout None 7 3.0% 6VPHA
DFGin BLAplus 1 0.4% 4J8MA
DFGin BLBminus 1 0.4% 8PR7D
DFGout BBAminus 1 0.4% 2C6EA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
1OL5A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 123 - 388 0 TPO287,TPO288 None Aurora kinase A
6VPGA 2.64 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A
5LXMA 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A
5G1XA 1.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A
7ZTLA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, BCN ATPlike, Allosteric 126 - 389 0 TPO288 C290A,K339C,C393A Aurora kinase A
AF-O14965-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 125 - 391 0 None None Aurora kinase A
AF-O14965-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 125 - 391 0 None None Aurora kinase A
4C3PD 2.69 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaooi APEdist_nooo ACP ATPlike 125 - 390 0 None None Aurora kinase A
8GUWA 2.7 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno ADP ATPlike 506 - 388 0 None C290A,C393A Aurora kinase A
8GUWB 2.7 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aanoo APEdist_nnnn ADP ATPlike 507 - 390 0 None C290A,C393A Aurora kinase A
8GUWC 2.7 Inactive DFGin‑ABAminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 506 - 388 0 None C290A,C393A Aurora kinase A
5DPVA 2.285 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaiii APEdist_nnoo 5DN, SKE Allosteric, Type1 127 - 389 0 None T287A Aurora kinase A
5DR6A 2.534 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaiii APEdist_nnoo 5E1, SKE Allosteric, Type1 127 - 390 0 None T287A Aurora kinase A
2WTWA 3.302 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo ZZL Type1 128 - 389 0 None L215R,T217E,R220K Aurora kinase A
3E5AA 2.3 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii VX6 Type1 125 - 389 0 TPO288 None Aurora kinase A
2NP8A 2.25 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn CC3 Type1 127 - 388 0 None None Aurora kinase A
4BYIA 2.6 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno FH3 Type1 126 - 388 0 None None Aurora kinase A
5ONEA 2.6 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaooi APEdist_nooo 9YQ Type1 127 - 391 0 None None Aurora kinase A
5DT0A 2.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo SKE Type1 127 - 390 0 None None Aurora kinase A
3UODA 2.5 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiio 0C3 Type1 124 - 389 0 None T287D Aurora kinase A
3UP2A 2.3 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo 0C8 Type1 124 - 389 0 None T287D Aurora kinase A
4DEAA 2.45 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo NHI Type1 124 - 389 0 None T287D Aurora kinase A
5AAFA 2.78 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnno NL4 Type1 126 - 388 0 None C290A,C393A Aurora kinase A
5AAGA 2.85 Inactive DFGin‑ABAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno 6F2 Type1 127 - 388 0 None C290A,C393A Aurora kinase A
6GRAA 2.6 Inactive DFGin‑ABAminus out-out none-none nonTYR APEdihe_aanni APEdist_nnnn F8Z Type1.5_Front 126 - 389 0 None None Aurora kinase A
4BN1A 2.499 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 126 - 388 0 TPO287,TPO288 V174M Aurora kinase A
1MQ4A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 126 - 388 0 None None Aurora kinase A
5DNRA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ATP ATPlike 126 - 390 0 TPO288 None Aurora kinase A
5DT3A 2.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ATP ATPlike 127 - 390 0 TPO287 None Aurora kinase A
1OL7A 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 127 - 390 0 TPO287,TPO288 None Aurora kinase A
5G15A 2.06 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 126 - 390 0 None None Aurora kinase A
2DWBA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 126 - 389 0 None None Aurora kinase A
6CPFA 2.3 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 128 - 392 0 None None Aurora kinase A
5DRDA 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ATP ATPlike 127 - 390 0 None T287A Aurora kinase A
4DEEA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 124 - 394 0 None T287D Aurora kinase A
6VPIA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A
4CEGA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
1OL6A 3.0 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ATP ATPlike 128 - 388 0 None D274N Aurora kinase A
6VPLA 1.86 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo ANP, R7D ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A
6VPLB 1.86 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo ANP, R7D ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A
6VPMA 1.58 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_oooo AMP, R74 ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A
6VPMB 1.58 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo AMP, R74 ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A
5ORLA 1.69 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A4W ATPlike, Allosteric 127 - 391 0 TPO288 C290A Aurora kinase A
5ORNA 2.19 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OROA 2.12 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORPA 2.19 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5K ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORRA 2.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5Q ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORSA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5W ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORTA 2.56 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5Z ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORVA 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A65 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORWA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORXA 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORYA 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, AY4 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5ORZA 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6W ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OS0A 1.74 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6Z ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OS1A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OS2A 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ADP, A7K ATPlike, Allosteric 127 - 391 0 None None Aurora kinase A
5OS3A 1.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7N ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OS4A 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A8H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OS6A 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7Q ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OSEA 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A98 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OSFA 1.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A9E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
5OSDA 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A9B ATPlike, Allosteric 125 - 391 0 TPO288 None Aurora kinase A
5OS5A 1.74 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A8K ATPlike, Allosteric 125 - 392 0 TPO288 None Aurora kinase A
6R49A 2.209 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, JSB ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
6R4AA 1.937 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRT ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
6R4BA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JSN ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
6R4CA 2.04 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRQ ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
6R4DA 2.009 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRW ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
8OF5A 1.97 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo ADP, MPO ATPlike, Allosteric 126 - 390 0 None C290A,N332A,Q335A,C393A Aurora kinase A
8C14A 1.93 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ADP, T5L, T0L ATPlike, Allosteric, Allosteric 126 - 389 0 TPO288 None Aurora kinase A
8C15A 2.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T4C, T5L ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A
8C1FA 1.924 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T5L, T2O ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A
8C1IA 2.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T1L, T5L ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A
5DN3A 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo 5DN, ATP Allosteric, ATPlike 125 - 389 0 TPO288 None Aurora kinase A
8C1EA 2.798 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo T0X, ATP Allosteric, ATPlike 127 - 388 0 TPO288 None Aurora kinase A
5DT4A 2.86 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 5DN, ATP Allosteric, ATPlike 127 - 390 0 None None Aurora kinase A
8C1MA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo T4X, ADP Allosteric, ATPlike 127 - 389 0 TPO288 None Aurora kinase A
5DOSA 2.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 5DN, ATP Allosteric, ATPlike 127 - 390 0 None T287A Aurora kinase A
5DR2A 2.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 5E1, ATP Allosteric, ATPlike 128 - 390 0 None T287A Aurora kinase A
8C1DA 2.115 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T2F, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
8C1GA 1.96 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T3I, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
8C1HA 2.233 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T3U, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
8C1KA 2.43 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo T4O, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
8SSPA 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii PDO, 627 Allosteric, Type1 126 - 389 0 None None Aurora kinase A
6CPEA 2.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 127 - 389 0 None None Aurora kinase A
4J8NA 3.135 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooo APEdist_iioo No_ligand No_ligand 125 - 390 0 None None Aurora kinase A
4J8NB 3.135 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iioo No_ligand No_ligand 125 - 390 0 None None Aurora kinase A
4J8NC 3.135 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 125 - 390 0 None None Aurora kinase A
4J8ND 3.135 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 126 - 390 0 None None Aurora kinase A
8JG8A 2.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo C74 Type1 127 - 389 0 None None Aurora kinase A
3HA6A 2.36 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 2JZ Type1 125 - 388 0 TPO287,TPO288 None Aurora kinase A
3VAPA 2.66 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 0FY Type1 127 - 388 0 None None Aurora kinase A
2W1CA 3.24 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iooo L0C Type1 127 - 389 0 TPO287,TPO288 None Aurora kinase A
2W1DA 2.97 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0D Type1 127 - 389 0 None None Aurora kinase A
2W1EA 2.93 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0E Type1 127 - 389 0 None None Aurora kinase A
2W1FA 2.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0F Type1 127 - 389 0 None None Aurora kinase A
2W1GA 2.71 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0G Type1 127 - 389 0 TPO287,TPO288 None Aurora kinase A
5ZANA 2.85 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno 9A6 Type1 127 - 389 0 None None Aurora kinase A
4O0SA 2.5 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo ADN Type1 126 - 391 0 None None Aurora kinase A
2XNGA 2.605 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn A0H Type1 127 - 390 0 None None Aurora kinase A
4JAJA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo XU1 Type1 125 - 389 0 None None Aurora kinase A
2X6DA 2.796 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnoo X6D Type1 126 - 388 0 None None Aurora kinase A
2X6EA 3.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aanoi APEdist_nnnn YM4 Type1 126 - 388 0 None None Aurora kinase A
4ZS0A 3.0 Inactive DFGin‑BLAminus out-out in-none nonTYR APEdihe_aanii APEdist_nnnn 4QV Type1 127 - 388 0 None None Aurora kinase A
6I2UA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo COA Type1 127 - 391 0 TPO287,TPO288 None Aurora kinase A
2XRUA 2.9 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nnoo 400 Type1 126 - 389 0 None T288E Aurora kinase A
3UO4A 2.45 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaoii APEdist_iioo 0C0 Type1 124 - 389 0 None T287D Aurora kinase A
3UO5A 2.701 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo 0BX Type1 124 - 390 0 None T287D Aurora kinase A
3UP7A 3.05 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo 0C9 Type1 124 - 387 0 None T287D Aurora kinase A
4DEBA 3.05 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iioo NHJ Type1 125 - 388 0 None T287D Aurora kinase A
4DEDA 3.05 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo NHU Type1 124 - 388 0 None T287D Aurora kinase A
4JBOA 2.493 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo WPH Type1 126 - 391 0 None T288D Aurora kinase A
3NRMA 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioo NRM Type1 126 - 388 0 None T287A,T288A Aurora kinase A
3R21A 2.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nooo D36 Type1 127 - 389 0 None T287D,T288D Aurora kinase A
5AADA 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5GX Type1 127 - 388 0 None C290A,C393A Aurora kinase A
2XNEA 2.8 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aanoi APEdist_nnnn ASH Type1 127 - 388 0 None D274N Aurora kinase A
5DR9A 2.47 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo SKE, 5E2 Type1, Allosteric 127 - 390 0 None T287A Aurora kinase A
3M11A 2.75 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnno AKI Type1.5_Front 126 - 391 0 None T288D Aurora kinase A
4JBPA 2.45 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno YPH Type1.5_Front 126 - 390 0 None T288D Aurora kinase A
4J8MA 1.853 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo CJ5 Type1 125 - 390 0 None T287D Aurora kinase A
8PR7D 2.76 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 388 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A
4C3PA 2.69 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaooi APEdist_oooo ACP ATPlike 125 - 388 0 None None Aurora kinase A
2C6DA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 126 - 390 0 None None Aurora kinase A
5ODTA 2.021 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 392 0 None D274N,C290A,C393A Aurora kinase A
5OBJA 2.901 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo ATP, 9QK ATPlike, Allosteric 127 - 390 0 None None Aurora kinase A
9GUCA 2.1 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aaiii APEdist_nnni ADP, AMP ATPlike, Allosteric 124 - 391 0 None C290A,C393A Aurora kinase A
8JF4A 2.893 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnoo C0N Type1 127 - 389 0 None None Aurora kinase A
8JMXA 2.95 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaooo APEdist_nnno E47 Type1 127 - 389 0 None None Aurora kinase A
7AYIA 2.86 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn S9K Type1 125 - 392 0 None None Aurora kinase A
2J4ZB 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 626 Type1 126 - 395 0 None None Aurora kinase A
4O0WA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_nioo ADN Type1 125 - 391 0 None H254Y Aurora kinase A
3H0ZA 2.92 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 45B Type1 128 - 388 0 None K124A,T287A,T288A Aurora kinase A
4DHFA 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_nnoo 0K6 Type1 128 - 389 0 None T287D,T288D Aurora kinase A
4DHFB 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_nnoo 0K6 Type1 128 - 389 0 None T287D,T288D Aurora kinase A
4PRJA 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_nnoo 2VU Type1 125 - 388 0 None K124A,Q154N,A203S,R251K,T287A,T288A,E336D Aurora kinase A
5AAEA 3.11 Inactive DFGin‑None out-none in-out nonTYR APEdihe_aaioi APEdist_nnno 7HD Type1 126 - 388 0 None C290A,C393A Aurora kinase A
4O0UA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_oooo ADN Type1 126 - 391 0 None H254R Aurora kinase A
4UZDA 3.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno QMN Type1.5_Front 127 - 388 0 None None Aurora kinase A
4UZDB 3.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo QMN Type1.5_Front 125 - 389 0 None None Aurora kinase A
4UYNA 1.9 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn Y3M Type1.5_Front 125 - 391 0 None None Aurora kinase A
4C3RA 2.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A
6C83B 2.55 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A
5L8JA 1.68 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 126 - 391 0 TPO288 C290A,C393A Aurora kinase A
5L8KA 1.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A
5L8LA 1.67 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A
8PR7A 2.76 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ADP ATPlike 124 - 389 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A
6XKAA 2.65 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 127 - 388 0 None None Aurora kinase A
2WTVA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo ZZL Type1 125 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A
2WTVB 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ZZL Type1 126 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A
2WTVC 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ZZL Type1 126 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A
2WTVD 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ZZL Type1 125 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A
5EW9A 2.181 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo 5VC Type1 127 - 390 0 TPO287,TPO288 None Aurora kinase A
6C2RA 1.96 Inactive DFGinter‑None out-none out-out nonTYR APEdihe_aanoi APEdist_nnnn EG7 Type1 128 - 389 0 None None Aurora kinase A
6C2TA 1.73 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo EGJ Type1 128 - 388 0 None None Aurora kinase A
3W16A 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioo APEdist_nnno P9J Type1 126 - 388 0 None None Aurora kinase A
2J50A 3.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 627 Type1 128 - 389 0 None None Aurora kinase A
2J50B 3.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 627 Type1 128 - 389 0 None None Aurora kinase A
4ZTRA 2.85 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 4RJ Type1 127 - 388 0 None None Aurora kinase A
6Z4YA 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo Q7Q Type1 124 - 389 0 None None Aurora kinase A
6CPGA 2.8 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoni APEdist_nnoo 35R Type1 127 - 387 0 None None Aurora kinase A
6CPGD 2.8 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nooo 35R Type1 127 - 388 0 None None Aurora kinase A
8SSOA 1.97 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nooo 627 Type1 127 - 389 0 None None Aurora kinase A
8SSOD 1.97 Inactive DFGinter‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 627 Type1 127 - 389 0 None None Aurora kinase A
1MUOA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nooo ADN Type1 128 - 388 0 None None Aurora kinase A
2J4ZA 2.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oioo 626 Type1 126 - 389 0 None None Aurora kinase A
3UNZA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BZ Type1 127 - 389 0 None T287D Aurora kinase A
3UNZB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BZ Type1 127 - 389 0 None T287D Aurora kinase A
3UO6A 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BY Type1 126 - 389 0 None T287D Aurora kinase A
3UO6B 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BY Type1 126 - 389 0 None T287D Aurora kinase A
3UOHA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C4 Type1 126 - 389 0 None T287D Aurora kinase A
3UOHB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C4 Type1 126 - 389 0 None T287D Aurora kinase A
3UOJA 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C5 Type1 127 - 389 0 None T287D Aurora kinase A
3UOJB 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C5 Type1 127 - 389 0 None T287D Aurora kinase A
3UOKA 2.951 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C6 Type1 125 - 389 0 None T287D Aurora kinase A
3UOKB 2.951 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C6 Type1 125 - 389 0 None T287D Aurora kinase A
3UOLA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C7 Type1 127 - 389 0 None T287D Aurora kinase A
3UOLB 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C7 Type1 127 - 389 0 None T287D Aurora kinase A
3FDNA 1.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo MMH Type1 126 - 394 0 None T288D Aurora kinase A
3K5UA 2.35 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo PFQ Type1 126 - 394 0 None T288D Aurora kinase A
4JBQA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo VX6 Type1 126 - 391 0 None T288D Aurora kinase A
3LAUA 2.1 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn OFI Type1 125 - 391 0 None T288D Aurora kinase A
4UZHA 2.0 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn JVE Type1 125 - 392 0 None None Aurora kinase A
3H0YA 2.5 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 48B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A
3H10A 2.2 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo 97B Type1 124 - 391 0 None K124A,T287A,T288A Aurora kinase A
3H10B 2.2 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo 97B Type1 125 - 391 0 None K124A,T287A,T288A Aurora kinase A
3H10D 2.2 Inactive DFGinter‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 97B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A
3P9JA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno P9J Type1 126 - 388 0 None T287A,T288A Aurora kinase A
3W10A 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo RO9 Type1 126 - 388 0 None T287A,T288A Aurora kinase A
3R22A 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno D37 Type1 126 - 389 0 None T287D,T288D Aurora kinase A
9KDSA 2.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno A1EFT Type1 126 - 391 0 None C290A Aurora kinase A
2BMCA 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A
2BMCB 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 125 - 394 0 None None Aurora kinase A
2BMCC 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 125 - 393 0 None None Aurora kinase A
2BMCD 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A
2BMCE 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A
2BMCF 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 126 - 394 0 None None Aurora kinase A
7FICA 2.32 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnoo 5YZ Type1 127 - 391 0 None C290A Aurora kinase A
9BZGA 1.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo OG0 Type1 127 - 388 0 TPO288 C290A,C393S Aurora kinase A
9BZLB 1.81 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo OGR Type1 127 - 388 0 TPO288 C290A,C393S Aurora kinase A
9KS6A 2.75 Inactive DFGinter‑None out-na none-none nonTYR APEdihe_aanii APEdist_nnnn A1EG1 Type1 127 - 391 0 None None Aurora kinase A
4ZTQA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 4RM Type1.5_Back 127 - 388 0 None None Aurora kinase A
4ZTSA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 4RK Type1.5_Back 127 - 388 0 None None Aurora kinase A
3EFWA 2.29 Inactive DFGinter‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 388 0 None None Aurora kinase A
3EFWB 2.29 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 389 0 None None Aurora kinase A
3O50A 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn LJE Type1.5_Front 126 - 388 0 None None Aurora kinase A
3O50B 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno LJE Type1.5_Front 126 - 389 0 None None Aurora kinase A
6HJJA 2.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno G7T Type1.5_Front 127 - 393 0 None L210C,C290A,C393A Aurora kinase A
2C6EA 2.1 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno HPM Type1.5_Back 127 - 389 0 None None Aurora kinase A
6VPJA 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A
6VPHA 2.14 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A
4JAIA 3.2 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn XU2 Type1 126 - 390 0 None None Aurora kinase A
7AYHA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn S9H Type1 125 - 390 0 None None Aurora kinase A
7O2VA 3.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo V0K Type1 117 - 390 0 None None Aurora kinase A
3O51A 3.2 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LJF Type1.5_Front 126 - 388 0 None None Aurora kinase A
6HJKA 2.4 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaoii APEdist_nnoo G7W Type1.5_Front 127 - 391 0 None L210C,C290A,C393A Aurora kinase A
6C83A 2.55 Inactive None‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 389 0 None None Aurora kinase A
2WQEA 2.5 Inactive None‑None out-none none-out nonTYR APEdihe_aaoii APEdist_nnno ADP, ADP, ADP ATPlike, ATPlike, ATPlike 127 - 388 0 None S155R Aurora kinase A
5OBRA 2.62 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 9QT, SKE Allosteric, Type1 126 - 390 0 None None Aurora kinase A
3W2CC 2.45 Inactive None‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn N15 Type1 128 - 388 0 None None Aurora kinase A
3W2CE 2.45 Inactive None‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn N15 Type1 128 - 388 0 None None Aurora kinase A
2X81A 2.91 Inactive None‑None out-none none-out nonTYR APEdihe_aaioi APEdist_nnno ZZL Type1 127 - 388 0 None None Aurora kinase A
3W18A 2.5 Inactive None‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno N13 Type1 126 - 388 0 None None Aurora kinase A
3W18B 2.5 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno N13 Type1 126 - 388 0 None None Aurora kinase A
4B0GA 2.5 Inactive None‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn VEK Type1 126 - 391 0 None None Aurora kinase A
4BYJA 2.75 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn FH5 Type1 126 - 388 0 None None Aurora kinase A
3H0ZB 2.92 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 45B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A
3H0ZC 2.92 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 45B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A
3COHA 2.7 Inactive None‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno 83H Type1 128 - 388 0 None K124A,Q154N,A203S,R251K,T287A,T288A,E336D Aurora kinase A
3COHB 2.7 Inactive None‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno 83H Type1 128 - 388 0 None K124A,Q154N,A203S,R251K,T287A,T288A,E336D Aurora kinase A
3QBNA 3.5 Inactive None‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno E9Z Type1 126 - 388 0 None V279C,C290S,C393S Aurora kinase A
3W2CA 2.45 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn N15 Type1.5_Back 128 - 388 0 None None Aurora kinase A
3W2CG 2.45 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn N15 Type1.5_Back 128 - 388 0 None None Aurora kinase A
2C6EB 2.1 Inactive None‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnni HPM Type1.5_Front 127 - 388 0 None None Aurora kinase A
3MYGA 2.4 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn EML Type1 126 - 388 0 None None Aurora kinase A

CAMK_AURKA (Aurora kinase A)

Total number of chains: 243
Active chains: 7
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 108 44.4% AF-O14965-K1A
DFGinter None 68 28.0% 5L8LA
DFGin None 21 8.6% 2J4ZB
DFGin ABAminus 18 7.4% 3E5AA
None None 18 7.4% 5OBRA
DFGout None 7 2.9% 6VPHA
DFGin BLAplus 1 0.4% 4J8MA
DFGin BLBminus 1 0.4% 8PR7D
DFGout BBAminus 1 0.4% 2C6EA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AURKA_HUMAN 1OL5A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 123 - 388 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 6VPGA 2.64 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5LXMA 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 5G1XA 1.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 7ZTLA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, BCN ATPlike, Allosteric 126 - 389 0 TPO288 C290A,K339C,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN AF-O14965-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 125 - 391 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN AF-O14965-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 125 - 391 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4C3PD 2.69 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaooi APEdist_nooo ACP ATPlike 125 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 8GUWA 2.7 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno ADP ATPlike 506 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 8GUWB 2.7 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aanoo APEdist_nnnn ADP ATPlike 507 - 390 0 None C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 8GUWC 2.7 Inactive DFGin‑ABAminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 506 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 5DPVA 2.285 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaiii APEdist_nnoo 5DN, SKE Allosteric, Type1 127 - 389 0 None T287A Aurora kinase A Homo sapiens
AURKA_HUMAN 5DR6A 2.534 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaiii APEdist_nnoo 5E1, SKE Allosteric, Type1 127 - 390 0 None T287A Aurora kinase A Homo sapiens
AURKA_HUMAN 2WTWA 3.302 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo ZZL Type1 128 - 389 0 None L215R,T217E,R220K Aurora kinase A Homo sapiens
AURKA_HUMAN 3E5AA 2.3 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii VX6 Type1 125 - 389 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 2NP8A 2.25 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn CC3 Type1 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4BYIA 2.6 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno FH3 Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ONEA 2.6 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaooi APEdist_nooo 9YQ Type1 127 - 391 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 5DT0A 2.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo SKE Type1 127 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3UODA 2.5 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiio 0C3 Type1 124 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UP2A 2.3 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo 0C8 Type1 124 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 4DEAA 2.45 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo NHI Type1 124 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 5AAFA 2.78 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnno NL4 Type1 126 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 5AAGA 2.85 Inactive DFGin‑ABAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno 6F2 Type1 127 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 6GRAA 2.6 Inactive DFGin‑ABAminus out-out none-none nonTYR APEdihe_aanni APEdist_nnnn F8Z Type1.5_Front 126 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4BN1A 2.499 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 126 - 388 0 TPO287,TPO288 V174M Aurora kinase A Homo sapiens
AURKA_HUMAN 1MQ4A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 5DNRA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ATP ATPlike 126 - 390 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5DT3A 2.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ATP ATPlike 127 - 390 0 TPO287 None Aurora kinase A Homo sapiens
AURKA_HUMAN 1OL7A 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 127 - 390 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5G15A 2.06 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 126 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2DWBA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 126 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6CPFA 2.3 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 128 - 392 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 5DRDA 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ATP ATPlike 127 - 390 0 None T287A Aurora kinase A Homo sapiens
AURKA_HUMAN 4DEEA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 124 - 394 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 6VPIA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4CEGA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 1OL6A 3.0 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ATP ATPlike 128 - 388 0 None D274N Aurora kinase A Homo sapiens
AURKA_HUMAN 6VPLA 1.86 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo ANP, R7D ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 6VPLB 1.86 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo ANP, R7D ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 6VPMA 1.58 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_oooo AMP, R74 ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 6VPMB 1.58 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo AMP, R74 ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORLA 1.69 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A4W ATPlike, Allosteric 127 - 391 0 TPO288 C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORNA 2.19 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OROA 2.12 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORPA 2.19 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5K ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORRA 2.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5Q ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORSA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5W ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORTA 2.56 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5Z ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORVA 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A65 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORWA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORXA 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORYA 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, AY4 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ORZA 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6W ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OS0A 1.74 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6Z ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OS1A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OS2A 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ADP, A7K ATPlike, Allosteric 127 - 391 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OS3A 1.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7N ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OS4A 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A8H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OS6A 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7Q ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OSEA 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A98 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OSFA 1.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A9E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OSDA 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A9B ATPlike, Allosteric 125 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5OS5A 1.74 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A8K ATPlike, Allosteric 125 - 392 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 6R49A 2.209 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, JSB ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 6R4AA 1.937 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRT ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 6R4BA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JSN ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 6R4CA 2.04 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRQ ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 6R4DA 2.009 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRW ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 8OF5A 1.97 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo ADP, MPO ATPlike, Allosteric 126 - 390 0 None C290A,N332A,Q335A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 8C14A 1.93 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ADP, T5L, T0L ATPlike, Allosteric, Allosteric 126 - 389 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 8C15A 2.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T4C, T5L ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 8C1FA 1.924 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T5L, T2O ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 8C1IA 2.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T1L, T5L ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 5DN3A 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo 5DN, ATP Allosteric, ATPlike 125 - 389 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 8C1EA 2.798 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo T0X, ATP Allosteric, ATPlike 127 - 388 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5DT4A 2.86 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 5DN, ATP Allosteric, ATPlike 127 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 8C1MA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo T4X, ADP Allosteric, ATPlike 127 - 389 0 TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5DOSA 2.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 5DN, ATP Allosteric, ATPlike 127 - 390 0 None T287A Aurora kinase A Homo sapiens
AURKA_HUMAN 5DR2A 2.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 5E1, ATP Allosteric, ATPlike 128 - 390 0 None T287A Aurora kinase A Homo sapiens
AURKA_HUMAN 8C1DA 2.115 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T2F, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 8C1GA 1.96 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T3I, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 8C1HA 2.233 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T3U, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 8C1KA 2.43 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo T4O, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 8SSPA 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii PDO, 627 Allosteric, Type1 126 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6CPEA 2.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4J8NA 3.135 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooo APEdist_iioo No_ligand No_ligand 125 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4J8NB 3.135 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iioo No_ligand No_ligand 125 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4J8NC 3.135 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 125 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4J8ND 3.135 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 126 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 8JG8A 2.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo C74 Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3HA6A 2.36 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 2JZ Type1 125 - 388 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 3VAPA 2.66 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 0FY Type1 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2W1CA 3.24 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iooo L0C Type1 127 - 389 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 2W1DA 2.97 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0D Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2W1EA 2.93 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0E Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2W1FA 2.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0F Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2W1GA 2.71 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0G Type1 127 - 389 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ZANA 2.85 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno 9A6 Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4O0SA 2.5 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo ADN Type1 126 - 391 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2XNGA 2.605 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn A0H Type1 127 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4JAJA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo XU1 Type1 125 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2X6DA 2.796 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnoo X6D Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2X6EA 3.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aanoi APEdist_nnnn YM4 Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4ZS0A 3.0 Inactive DFGin‑BLAminus out-out in-none nonTYR APEdihe_aanii APEdist_nnnn 4QV Type1 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6I2UA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo COA Type1 127 - 391 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 2XRUA 2.9 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nnoo 400 Type1 126 - 389 0 None T288E Aurora kinase A Homo sapiens
AURKA_HUMAN 3UO4A 2.45 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaoii APEdist_iioo 0C0 Type1 124 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UO5A 2.701 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo 0BX Type1 124 - 390 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UP7A 3.05 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo 0C9 Type1 124 - 387 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 4DEBA 3.05 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iioo NHJ Type1 125 - 388 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 4DEDA 3.05 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo NHU Type1 124 - 388 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 4JBOA 2.493 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo WPH Type1 126 - 391 0 None T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 3NRMA 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioo NRM Type1 126 - 388 0 None T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3R21A 2.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nooo D36 Type1 127 - 389 0 None T287D,T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 5AADA 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5GX Type1 127 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 2XNEA 2.8 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aanoi APEdist_nnnn ASH Type1 127 - 388 0 None D274N Aurora kinase A Homo sapiens
AURKA_HUMAN 5DR9A 2.47 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo SKE, 5E2 Type1, Allosteric 127 - 390 0 None T287A Aurora kinase A Homo sapiens
AURKA_HUMAN 3M11A 2.75 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnno AKI Type1.5_Front 126 - 391 0 None T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 4JBPA 2.45 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno YPH Type1.5_Front 126 - 390 0 None T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 4J8MA 1.853 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo CJ5 Type1 125 - 390 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 8PR7D 2.76 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 388 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 4C3PA 2.69 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaooi APEdist_oooo ACP ATPlike 125 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2C6DA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 126 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 5ODTA 2.021 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 392 0 None D274N,C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 5OBJA 2.901 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo ATP, 9QK ATPlike, Allosteric 127 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 9GUCA 2.1 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aaiii APEdist_nnni ADP, AMP ATPlike, Allosteric 124 - 391 0 None C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 8JF4A 2.893 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnoo C0N Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 8JMXA 2.95 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaooo APEdist_nnno E47 Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 7AYIA 2.86 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn S9K Type1 125 - 392 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2J4ZB 2.0 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 626 Type1 126 - 395 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4O0WA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_nioo ADN Type1 125 - 391 0 None H254Y Aurora kinase A Homo sapiens
AURKA_HUMAN 3H0ZA 2.92 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 45B Type1 128 - 388 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 4DHFA 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_nnoo 0K6 Type1 128 - 389 0 None T287D,T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 4DHFB 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaooo APEdist_nnoo 0K6 Type1 128 - 389 0 None T287D,T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 4PRJA 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_nnoo 2VU Type1 125 - 388 0 None K124A,Q154N,A203S,R251K,T287A,T288A,E336D Aurora kinase A Homo sapiens
AURKA_HUMAN 5AAEA 3.11 Inactive DFGin‑None out-none in-out nonTYR APEdihe_aaioi APEdist_nnno 7HD Type1 126 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 4O0UA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_oooo ADN Type1 126 - 391 0 None H254R Aurora kinase A Homo sapiens
AURKA_HUMAN 4UZDA 3.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno QMN Type1.5_Front 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4UZDB 3.2 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo QMN Type1.5_Front 125 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4UYNA 1.9 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn Y3M Type1.5_Front 125 - 391 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4C3RA 2.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6C83B 2.55 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 5L8JA 1.68 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 126 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 5L8KA 1.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 5L8LA 1.67 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 8PR7A 2.76 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ADP ATPlike 124 - 389 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 6XKAA 2.65 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2WTVA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo ZZL Type1 125 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A Homo sapiens
AURKA_HUMAN 2WTVB 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ZZL Type1 126 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A Homo sapiens
AURKA_HUMAN 2WTVC 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ZZL Type1 126 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A Homo sapiens
AURKA_HUMAN 2WTVD 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ZZL Type1 125 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A Homo sapiens
AURKA_HUMAN 5EW9A 2.181 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo 5VC Type1 127 - 390 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 6C2RA 1.96 Inactive DFGinter‑None out-none out-out nonTYR APEdihe_aanoi APEdist_nnnn EG7 Type1 128 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6C2TA 1.73 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo EGJ Type1 128 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3W16A 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioo APEdist_nnno P9J Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2J50A 3.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 627 Type1 128 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2J50B 3.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 627 Type1 128 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4ZTRA 2.85 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 4RJ Type1 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6Z4YA 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo Q7Q Type1 124 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6CPGA 2.8 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoni APEdist_nnoo 35R Type1 127 - 387 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6CPGD 2.8 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nooo 35R Type1 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 8SSOA 1.97 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nooo 627 Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 8SSOD 1.97 Inactive DFGinter‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 627 Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 1MUOA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nooo ADN Type1 128 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2J4ZA 2.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oioo 626 Type1 126 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3UNZA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BZ Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UNZB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BZ Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UO6A 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BY Type1 126 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UO6B 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BY Type1 126 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UOHA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C4 Type1 126 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UOHB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C4 Type1 126 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UOJA 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C5 Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UOJB 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C5 Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UOKA 2.951 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C6 Type1 125 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UOKB 2.951 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C6 Type1 125 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UOLA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C7 Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3UOLB 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C7 Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
AURKA_HUMAN 3FDNA 1.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo MMH Type1 126 - 394 0 None T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 3K5UA 2.35 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo PFQ Type1 126 - 394 0 None T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 4JBQA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo VX6 Type1 126 - 391 0 None T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 3LAUA 2.1 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn OFI Type1 125 - 391 0 None T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 4UZHA 2.0 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn JVE Type1 125 - 392 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3H0YA 2.5 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 48B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3H10A 2.2 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo 97B Type1 124 - 391 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3H10B 2.2 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo 97B Type1 125 - 391 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3H10D 2.2 Inactive DFGinter‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 97B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3P9JA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno P9J Type1 126 - 388 0 None T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3W10A 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo RO9 Type1 126 - 388 0 None T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3R22A 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno D37 Type1 126 - 389 0 None T287D,T288D Aurora kinase A Homo sapiens
AURKA_HUMAN 9KDSA 2.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno A1EFT Type1 126 - 391 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 2BMCA 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2BMCB 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 125 - 394 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2BMCC 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 125 - 393 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2BMCD 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2BMCE 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2BMCF 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 126 - 394 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 7FICA 2.32 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnoo 5YZ Type1 127 - 391 0 None C290A Aurora kinase A Homo sapiens
AURKA_HUMAN 9BZGA 1.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo OG0 Type1 127 - 388 0 TPO288 C290A,C393S Aurora kinase A Homo sapiens
AURKA_HUMAN 9BZLB 1.81 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo OGR Type1 127 - 388 0 TPO288 C290A,C393S Aurora kinase A Homo sapiens
AURKA_HUMAN 9KS6A 2.75 Inactive DFGinter‑None out-na none-none nonTYR APEdihe_aanii APEdist_nnnn A1EG1 Type1 127 - 391 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4ZTQA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 4RM Type1.5_Back 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4ZTSA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 4RK Type1.5_Back 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3EFWA 2.29 Inactive DFGinter‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3EFWB 2.29 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3O50A 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn LJE Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3O50B 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno LJE Type1.5_Front 126 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6HJJA 2.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno G7T Type1.5_Front 127 - 393 0 None L210C,C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 2C6EA 2.1 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno HPM Type1.5_Back 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6VPJA 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6VPHA 2.14 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
AURKA_HUMAN 4JAIA 3.2 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn XU2 Type1 126 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 7AYHA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn S9H Type1 125 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 7O2VA 3.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo V0K Type1 117 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3O51A 3.2 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LJF Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 6HJKA 2.4 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaoii APEdist_nnoo G7W Type1.5_Front 127 - 391 0 None L210C,C290A,C393A Aurora kinase A Homo sapiens
AURKA_HUMAN 6C83A 2.55 Inactive None‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 389 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2WQEA 2.5 Inactive None‑None out-none none-out nonTYR APEdihe_aaoii APEdist_nnno ADP, ADP, ADP ATPlike, ATPlike, ATPlike 127 - 388 0 None S155R Aurora kinase A Homo sapiens
AURKA_HUMAN 5OBRA 2.62 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 9QT, SKE Allosteric, Type1 126 - 390 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3W2CC 2.45 Inactive None‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn N15 Type1 128 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3W2CE 2.45 Inactive None‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn N15 Type1 128 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2X81A 2.91 Inactive None‑None out-none none-out nonTYR APEdihe_aaioi APEdist_nnno ZZL Type1 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3W18A 2.5 Inactive None‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno N13 Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3W18B 2.5 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno N13 Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4B0GA 2.5 Inactive None‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn VEK Type1 126 - 391 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 4BYJA 2.75 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn FH5 Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3H0ZB 2.92 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 45B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3H0ZC 2.92 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 45B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
AURKA_HUMAN 3COHA 2.7 Inactive None‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno 83H Type1 128 - 388 0 None K124A,Q154N,A203S,R251K,T287A,T288A,E336D Aurora kinase A Homo sapiens
AURKA_HUMAN 3COHB 2.7 Inactive None‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno 83H Type1 128 - 388 0 None K124A,Q154N,A203S,R251K,T287A,T288A,E336D Aurora kinase A Homo sapiens
AURKA_HUMAN 3QBNA 3.5 Inactive None‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno E9Z Type1 126 - 388 0 None V279C,C290S,C393S Aurora kinase A Homo sapiens
AURKA_HUMAN 3W2CA 2.45 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn N15 Type1.5_Back 128 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3W2CG 2.45 Inactive None‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn N15 Type1.5_Back 128 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 2C6EB 2.1 Inactive None‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnni HPM Type1.5_Front 127 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_HUMAN 3MYGA 2.4 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn EML Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
AURKA_MOUSE 3D14A 1.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK1 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3D15A 2.3 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno AK2 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3D2IA 2.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK3 Type1.5_Front 118 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3D2KA 2.5 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aanoi APEdist_nnnn AK4 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3DJ7A 2.8 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK7 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3DJ5A 1.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK5 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3DJ6A 1.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK6 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3DAJA 2.0 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn FXG Type1 118 - 379 0 None N164G,K218R,T278D,M280L Aurora kinase A Mus musculus

CAMK_AURKA (Aurora kinase A)

Total number of chains: 8
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 62.5% 3D14A
DFGin None 2 25.0% 3DJ6A
DFGinter None 1 12.5% 3DAJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AURKA_MOUSE 3D14A 1.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK1 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3D15A 2.3 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno AK2 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3D2IA 2.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK3 Type1.5_Front 118 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3D2KA 2.5 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aanoi APEdist_nnnn AK4 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3DJ7A 2.8 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK7 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3DJ5A 1.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK5 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3DJ6A 1.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK6 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
AURKA_MOUSE 3DAJA 2.0 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn FXG Type1 118 - 379 0 None N164G,K218R,T278D,M280L Aurora kinase A Mus musculus