AURKA (Aurora kinase A)

Group: CAMK
Uniprot: AURKA_HUMAN
Domain boundary: 133 - 383


Total number of chains: 231
Spatial Dihedral Chains Representative
DFGin BLAminus 102 AF-O14965-K1A
DFGin BLAplus 1 4J8MA
DFGin ABAminus 18 3E5AA
DFGin BLBminus 1 8PR7D
DFGin None 18 2J4ZB
DFGinter None 65 5L8LA
DFGout BBAminus 1 2C6EA
DFGout None 7 6VPHA
None None 18 5OBRA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
5DPVA 2.285 Inactive DFGin ABAminus out-in in-out 5DN SKE Allosteric Type1 127 - 389 T287A None 6
5DR6A 2.534 Inactive DFGin ABAminus out-in in-out 5E1 SKE Allosteric Type1 127 - 390 T287A None 7
2WTWA 3.302 Inactive DFGin ABAminus out-out in-out ZZL Type1 128 - 389 L215R,T217E,R220K None 6
3E5AA 2.3 Inactive DFGin ABAminus out-out in-in VX6 Type1 125 - 389 None X288 0
2NP8A 2.25 Inactive DFGin ABAminus out-out out-none CC3 Type1 127 - 388 None None 6
4C3PD 2.69 Inactive DFGin ABAminus out-out in-out ACP Type1 125 - 390 None None 6
4BYIA 2.6 Inactive DFGin ABAminus out-out in-out FH3 Type1 126 - 388 None None 9
5ONEA 2.6 Inactive DFGin ABAminus out-out out-out 9YQ Type1 127 - 391 None None 8
5DT0A 2.15 Inactive DFGin ABAminus in-in in-out SKE Type1 127 - 390 None None 5
3UODA 2.5 Inactive DFGin ABAminus out-out in-out 0C3 Type1 124 - 389 T287D None 0
3UP2A 2.3 Inactive DFGin ABAminus out-out in-out 0C8 Type1 124 - 389 T287D None 0
4DEAA 2.45 Inactive DFGin ABAminus out-out in-out NHI Type1 124 - 389 T287D None 0
5AAFA 2.78 Inactive DFGin ABAminus in-out in-out NL4 Type1 126 - 388 C290A,C393A None 9
5AAGA 2.85 Inactive DFGin ABAminus out-none in-out 6F2 Type1 127 - 388 C290A,C393A None 9
8GUWA 2.7 Inactive DFGin ABAminus out-out in-out ADP Type1 506 - 388 C290A,C393A None 7
8GUWB 2.7 Inactive DFGin ABAminus out-out none-none ADP Type1 507 - 390 C290A,C393A None 13
8GUWC 2.7 Inactive DFGin ABAminus out-out none-none ADP Type1 506 - 388 C290A,C393A None 14
6GRAA 2.6 Inactive DFGin ABAminus out-out none-none F8Z Type1.5_Front 126 - 389 None None 14
5DN3A 2.05 Inactive DFGin BLAminus in-in in-out 5DN ATP Allosteric Type1 125 - 389 None X288 0
8C1EA 2.798 Inactive DFGin BLAminus in-in in-out T0X ATP Allosteric Type1 127 - 388 None X288 0
5DT4A 2.86 Inactive DFGin BLAminus in-in in-out 5DN ATP Allosteric Type1 127 - 390 None None 5
8C1MA 2.84 Inactive DFGin BLAminus in-in in-out T4X ADP Allosteric Type1 127 - 389 None X288 0
8SSPA 2.6 Inactive DFGin BLAminus out-out in-in PDO 627 Allosteric Type1 126 - 389 None None 0
5DOSA 2.98 Inactive DFGin BLAminus in-in in-out 5DN ATP Allosteric Type1 127 - 390 T287A None 5
5DR2A 2.46 Inactive DFGin BLAminus in-in in-out 5E1 ATP Allosteric Type1 128 - 390 T287A None 0
8C1DA 2.115 Inactive DFGin BLAminus in-in in-out T2F ADP T5L Allosteric Type1 Allosteric 127 - 388 C290A None 3
8C1GA 1.96 Inactive DFGin BLAminus in-in in-out T3I ADP T5L Allosteric Type1 Allosteric 127 - 388 C290A None 4
8C1HA 2.233 Inactive DFGin BLAminus in-in in-out T3U ADP T5L Allosteric Type1 Allosteric 127 - 388 C290A None 4
8C1KA 2.43 Inactive DFGin BLAminus in-in in-out T4O ADP T5L Allosteric Type1 Allosteric 127 - 388 C290A None 0
AF-O14965-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 125 - 391 None None 0
6CPEA 2.45 None DFGin BLAminus in-in in-none No_ligand No_ligand 127 - 389 None None 7
4J8NA 3.135 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 125 - 390 None None 0
4J8NB 3.135 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 125 - 390 None None 0
4J8NC 3.135 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 125 - 390 None None 0
4J8ND 3.135 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 126 - 390 None None 0
4BN1A 2.499 Inactive DFGin BLAminus in-in in-out ADP Type1 126 - 388 V174M X287,X288 0
8JG8A 2.9 Inactive DFGin BLAminus out-out in-out C74 Type1 127 - 389 None None 8
3HA6A 2.36 Inactive DFGin BLAminus in-out in-in 2JZ Type1 125 - 388 None X287,X288 0
1MQ4A 1.9 Inactive DFGin BLAminus in-in in-out ADP Type1 126 - 388 None None 2
3MYGA 2.4 None DFGin BLAminus in-in in-none EML Type1 126 - 388 None None 11
3VAPA 2.66 None DFGin BLAminus in-in none-out 0FY Type1 127 - 388 None None 13
5DNRA 1.95 Inactive DFGin BLAminus in-in in-out ATP Type1 126 - 390 None X288 0
5DT3A 2.33 Inactive DFGin BLAminus in-in in-out ATP Type1 127 - 390 None X287 0
2W1CA 3.24 Inactive DFGin BLAminus out-out in-out L0C Type1 127 - 389 None X287,X288 0
2W1DA 2.97 Inactive DFGin BLAminus in-out in-out L0D Type1 127 - 389 None None 11
2W1EA 2.93 Inactive DFGin BLAminus out-out in-out L0E Type1 127 - 389 None None 11
2W1FA 2.85 Inactive DFGin BLAminus out-out in-out L0F Type1 127 - 389 None None 10
2W1GA 2.71 Inactive DFGin BLAminus in-out in-out L0G Type1 127 - 389 None X287,X288 9
5ZANA 2.85 None DFGin BLAminus out-none in-out 9A6 Type1 127 - 389 None None 5
1OL5A 2.5 Active DFGin BLAminus in-in in-in ADP Type1 123 - 388 None X287,X288 0
1OL7A 2.75 Inactive DFGin BLAminus in-in in-out ADP Type1 127 - 390 None X287,X288 0
4O0SA 2.5 Inactive DFGin BLAminus out-out in-out ADN Type1 126 - 391 None None 1
5G15A 2.06 Inactive DFGin BLAminus out-out in-in ACP Type1 126 - 390 None None 0
2XNGA 2.605 None DFGin BLAminus in-out in-none A0H Type1 127 - 390 None None 10
4JAJA 2.7 Inactive DFGin BLAminus in-in in-out XU1 Type1 125 - 389 None None 0
2DWBA 2.5 Inactive DFGin BLAminus in-in in-out ANP Type1 126 - 389 None None 2
2X6DA 2.796 Inactive DFGin BLAminus in-out in-out X6D Type1 126 - 388 None None 4
2X6EA 3.35 None DFGin BLAminus in-out in-none YM4 Type1 126 - 388 None None 11
4ZS0A 3.0 None DFGin BLAminus out-out in-none 4QV Type1 127 - 388 None None 5
6I2UA 2.5 Inactive DFGin BLAminus in-in in-out COA Type1 127 - 391 None X287,X288 0
6CPFA 2.3 None DFGin BLAminus out-none in-out ACP Type1 128 - 392 None None 6
6VPGA 2.64 Active DFGin BLAminus in-in in-in ANP Type1 104 - 389 None X287,X288 0
5DRDA 2.13 Inactive DFGin BLAminus in-in in-out ATP Type1 127 - 390 T287A None 5
2XRUA 2.9 Inactive DFGin BLAminus in-out in-out 400 Type1 126 - 389 T288E None 10
3UO4A 2.45 Inactive DFGin BLAminus out-out in-out 0C0 Type1 124 - 389 T287D None 0
3UO5A 2.701 Inactive DFGin BLAminus in-out in-out 0BX Type1 124 - 390 T287D None 0
3UP7A 3.05 Inactive DFGin BLAminus in-out in-out 0C9 Type1 124 - 387 T287D None 0
4DEBA 3.05 Inactive DFGin BLAminus out-out in-out NHJ Type1 125 - 388 T287D None 0
4DEDA 3.05 Inactive DFGin BLAminus in-out in-out NHU Type1 124 - 388 T287D None 0
4DEEA 2.3 Inactive DFGin BLAminus in-in in-out ADP Type1 124 - 394 T287D None 0
6VPIA 2.0 Inactive DFGin BLAminus in-in in-out ANP Type1 7 - 389 None None 0
4JBOA 2.493 Inactive DFGin BLAminus out-out in-out WPH Type1 126 - 391 T288D None 0
3NRMA 3.05 Inactive DFGin BLAminus in-in in-out NRM Type1 126 - 388 T287A,T288A None 0
3R21A 2.9 Inactive DFGin BLAminus out-out in-out D36 Type1 127 - 389 T287D,T288D None 9
5LXMA 2.08 Active DFGin BLAminus in-in in-in ADP Type1 126 - 392 C290A,C393A X288 0
4CEGA 2.1 Inactive DFGin BLAminus in-in in-out ADP Type1 127 - 391 C290A,C393A X288 0
5AADA 3.1 None DFGin BLAminus in-in in-none 5GX Type1 127 - 388 C290A,C393A None 10
5G1XA 1.72 Active DFGin BLAminus in-in in-in ADP Type1 126 - 389 C290A,C393A X288 0
2XNEA 2.8 None DFGin BLAminus out-out in-none ASH Type1 127 - 388 D274N None 9
1OL6A 3.0 None DFGin BLAminus in-out in-none ATP Type1 128 - 388 D274N None 11
6VPLA 1.86 Inactive DFGin BLAminus out-out in-out ANP R7D Type1 Allosteric 7 - 389 None X288 4
6VPLB 1.86 Inactive DFGin BLAminus out-out in-out ANP R7D Type1 Allosteric 7 - 389 None X288 4
6VPMA 1.58 Inactive DFGin BLAminus out-out in-out AMP R74 Type1 Allosteric 7 - 389 None X288 4
6VPMB 1.58 Inactive DFGin BLAminus out-out in-out AMP R74 Type1 Allosteric 7 - 389 None X288 4
5DR9A 2.47 Inactive DFGin BLAminus out-out out-out SKE 5E2 Type1 Allosteric 127 - 390 T287A None 7
5ORLA 1.69 Inactive DFGin BLAminus in-in in-out ADP A4W Type1 Allosteric 127 - 391 C290A X288 0
5ORNA 2.19 Inactive DFGin BLAminus in-in in-out ADP A5E Type1 Allosteric 127 - 391 None X288 0
5OROA 2.12 Inactive DFGin BLAminus in-in in-out ADP A5H Type1 Allosteric 127 - 391 None X288 0
5ORPA 2.19 Inactive DFGin BLAminus in-in in-out ADP A5K Type1 Allosteric 127 - 391 None X288 0
5ORRA 2.09 Inactive DFGin BLAminus in-in in-out ADP A5Q Type1 Allosteric 127 - 391 None X288 0
5ORSA 1.98 Inactive DFGin BLAminus in-in in-out ADP A5W Type1 Allosteric 127 - 391 None X288 0
5ORTA 2.56 Inactive DFGin BLAminus in-in in-out ADP A5Z Type1 Allosteric 127 - 391 None X288 0
5ORVA 1.88 Inactive DFGin BLAminus in-in in-out ADP A65 Type1 Allosteric 127 - 391 None X288 0
5ORWA 2.0 Inactive DFGin BLAminus in-in in-out ADP A6E Type1 Allosteric 127 - 391 None X288 0
5ORXA 1.88 Inactive DFGin BLAminus in-in in-out ADP A6H Type1 Allosteric 127 - 391 None X288 0
5ORYA 1.99 Inactive DFGin BLAminus in-in in-out ADP AY4 Type1 Allosteric 127 - 391 None X288 0
5ORZA 1.92 Inactive DFGin BLAminus in-in in-out ADP A6W Type1 Allosteric 127 - 391 None X288 0
5OS0A 1.74 Inactive DFGin BLAminus in-in in-out ADP A6Z Type1 Allosteric 127 - 391 None X288 0
5OS1A 1.9 Inactive DFGin BLAminus in-in in-out ADP A7H Type1 Allosteric 127 - 391 None X288 0
5OS2A 1.92 Inactive DFGin BLAminus in-in in-out ADP A7K Type1 Allosteric 127 - 391 None None 4
5OS3A 1.81 Inactive DFGin BLAminus in-in in-out ADP A7N Type1 Allosteric 127 - 391 None X288 0
5OS4A 1.88 Inactive DFGin BLAminus in-in in-out ADP A8H Type1 Allosteric 127 - 391 None X288 0
5OS6A 2.2 Inactive DFGin BLAminus in-in in-out ADP A7Q Type1 Allosteric 127 - 391 None X288 0
5OSEA 1.9 Inactive DFGin BLAminus in-in in-out ADP A98 Type1 Allosteric 127 - 391 None X288 0
5OSFA 1.89 Inactive DFGin BLAminus in-in in-out ADP A9E Type1 Allosteric 127 - 391 None X288 0
5OSDA 1.99 Inactive DFGin BLAminus in-in in-out ADP A9B Type1 Allosteric 125 - 391 None X288 0
5OS5A 1.74 Inactive DFGin BLAminus in-in in-out ADP A8K Type1 Allosteric 125 - 392 None X288 0
6R49A 2.209 Inactive DFGin BLAminus in-in in-out ADP JSB Type1 Allosteric 127 - 391 C290A,C393A X288 5
6R4AA 1.937 Inactive DFGin BLAminus in-in in-out ADP JRT Type1 Allosteric 127 - 391 C290A,C393A X288 0
6R4BA 2.15 Inactive DFGin BLAminus in-in in-out ADP JSN Type1 Allosteric 127 - 391 None X288 0
6R4CA 2.04 Inactive DFGin BLAminus in-in in-out ADP JRQ Type1 Allosteric 127 - 391 C290A,C393A X288 0
6R4DA 2.009 Inactive DFGin BLAminus in-in in-out ADP JRW Type1 Allosteric 127 - 391 C290A,C393A X288 0
7ZTLA 1.9 Active DFGin BLAminus in-in in-in ADP BCN Type1 Allosteric 126 - 389 C290A,K339C,C393A X288 0
8OF5A 1.97 Inactive DFGin BLAminus in-in in-out ADP MPO Type1 Allosteric 126 - 390 C290A,N332A,Q335A,C393A None 0
8C14A 1.93 Inactive DFGin BLAminus in-in in-out ADP T5L T0L Type1 Allosteric Allosteric 126 - 389 None X288 0
8C15A 2.41 Inactive DFGin BLAminus in-in in-out ADP T4C T5L Type1 Allosteric Allosteric 126 - 388 C290A None 4
8C1FA 1.924 Inactive DFGin BLAminus in-in in-out ADP T5L T2O Type1 Allosteric Allosteric 126 - 388 C290A None 5
8C1IA 2.81 Inactive DFGin BLAminus in-in in-out ADP T1L T5L Type1 Allosteric Allosteric 126 - 388 C290A None 3
3M11A 2.75 Inactive DFGin BLAminus out-out in-out AKI Type1.5_Front 126 - 391 T288D None 10
4JBPA 2.45 Inactive DFGin BLAminus out-out in-out YPH Type1.5_Front 126 - 390 T288D None 10
4J8MA 1.853 Inactive DFGin BLAplus out-out out-out CJ5 Type1 125 - 390 T287D None 0
8PR7D 2.76 Inactive DFGin BLBminus out-none none-out ADP Type1 126 - 388 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None 12
8JF4A 2.893 Inactive DFGin None out-none none-out C0N Type1 127 - 389 None None 11
8JMXA 2.95 Inactive DFGin None out-none none-out E47 Type1 127 - 389 None None 13
4C3PA 2.69 Inactive DFGin None out-out in-out ACP Type1 125 - 388 None None 0
7AYIA 2.86 Inactive DFGin None out-out none-none S9K Type1 125 - 392 None None 16
2J4ZB 2.0 Inactive DFGin None out-out out-out 626 Type1 126 - 395 None None 0
4O0WA 2.6 Inactive DFGin None out-out in-out ADN Type1 125 - 391 H254Y None 8
2C6DA 2.2 Inactive DFGin None out-out out-out ANP Type1 126 - 390 None None 10
3H0ZA 2.92 Inactive DFGin None out-out none-none 45B Type1 128 - 388 K124A,T287A,T288A None 13
4DHFA 2.8 Inactive DFGin None in-in in-out 0K6 Type1 128 - 389 T287D,T288D None 4
4DHFB 2.8 Inactive DFGin None in-in in-out 0K6 Type1 128 - 389 T287D,T288D None 4
4PRJA 2.8 Inactive DFGin None in-in in-out 2VU Type1 125 - 388 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None 10
5AAEA 3.11 Inactive DFGin None out-none in-out 7HD Type1 126 - 388 C290A,C393A None 11
4O0UA 2.6 Inactive DFGin None out-out in-out ADN Type1 126 - 391 H254R None 7
5ODTA 2.021 Inactive DFGin None out-out out-out ADP Type1 126 - 392 D274N,C290A,C393A None 9
5OBJA 2.901 Inactive DFGin None out-out in-out ATP 9QK Type1 Allosteric 127 - 390 None None 4
4UZDA 3.2 Inactive DFGin None out-out none-out QMN Type1.5_Front 127 - 388 None None 8
4UZDB 3.2 Inactive DFGin None out-out none-out QMN Type1.5_Front 125 - 389 None None 7
4UYNA 1.9 Inactive DFGin None out-out none-none Y3M Type1.5_Front 125 - 391 None None 16
6XKAA 2.65 Inactive DFGinter None out-out out-out No_ligand No_ligand 127 - 388 None None 10
2WTVA 2.4 Inactive DFGinter None out-out out-out ZZL Type1 125 - 389 L215R,T217E,R220K X287,X288 0
2WTVB 2.4 Inactive DFGinter None out-out out-out ZZL Type1 126 - 389 L215R,T217E,R220K X287,X288 0
2WTVC 2.4 Inactive DFGinter None out-out out-out ZZL Type1 126 - 389 L215R,T217E,R220K X287,X288 0
2WTVD 2.4 Inactive DFGinter None out-out out-out ZZL Type1 125 - 389 L215R,T217E,R220K X287,X288 0
5EW9A 2.181 Inactive DFGinter None out-out out-out 5VC Type1 127 - 390 None X287,X288 5
6C2RA 1.96 Inactive DFGinter None out-none out-none EG7 Type1 128 - 389 None None 12
6C2TA 1.73 Inactive DFGinter None out-out out-out EGJ Type1 128 - 388 None None 8
3W16A 2.8 Inactive DFGinter None out-out out-out P9J Type1 126 - 388 None None 11
2J50A 3.0 Inactive DFGinter None out-out out-out 627 Type1 128 - 389 None None 8
2J50B 3.0 Inactive DFGinter None out-out out-out 627 Type1 128 - 389 None None 8
4C3RA 2.79 Inactive DFGinter None out-out out-out ACP Type1 127 - 388 None None 10
4ZTRA 2.85 Inactive DFGinter None out-out none-out 4RJ Type1 127 - 388 None None 13
6Z4YA 2.25 Inactive DFGinter None out-out out-out Q7Q Type1 124 - 389 None None 7
6C83B 2.55 Inactive DFGinter None out-out none-out ACP Type1 127 - 388 None None 15
6CPGA 2.8 Inactive DFGinter None out-out none-out 35R Type1 127 - 387 None None 12
6CPGD 2.8 Inactive DFGinter None out-out none-out 35R Type1 127 - 388 None None 10
8SSOA 1.97 Inactive DFGinter None out-out out-out 627 Type1 127 - 389 None None 7
8SSOD 1.97 Inactive DFGinter None out-out out-none 627 Type1 127 - 389 None None 11
1MUOA 2.9 Inactive DFGinter None out-out none-out ADN Type1 128 - 388 None None 10
2J4ZA 2.0 Inactive DFGinter None out-out out-out 626 Type1 126 - 389 None None 0
3UNZA 2.8 Inactive DFGinter None out-out out-out 0BZ Type1 127 - 389 T287D None 0
3UNZB 2.8 Inactive DFGinter None out-out out-out 0BZ Type1 127 - 389 T287D None 0
3UO6A 2.8 Inactive DFGinter None out-out out-out 0BY Type1 126 - 389 T287D None 0
3UO6B 2.8 Inactive DFGinter None out-out out-out 0BY Type1 126 - 389 T287D None 0
3UOHA 2.8 Inactive DFGinter None out-out out-out 0C4 Type1 126 - 389 T287D None 0
3UOHB 2.8 Inactive DFGinter None out-out out-out 0C4 Type1 126 - 389 T287D None 0
3UOJA 2.9 Inactive DFGinter None out-out out-out 0C5 Type1 127 - 389 T287D None 0
3UOJB 2.9 Inactive DFGinter None out-out out-out 0C5 Type1 127 - 389 T287D None 0
3UOKA 2.951 Inactive DFGinter None out-out out-out 0C6 Type1 125 - 389 T287D None 0
3UOKB 2.951 Inactive DFGinter None out-out out-out 0C6 Type1 125 - 389 T287D None 0
3UOLA 2.4 Inactive DFGinter None out-out out-out 0C7 Type1 127 - 389 T287D None 0
3UOLB 2.4 Inactive DFGinter None out-out out-out 0C7 Type1 127 - 389 T287D None 0
3FDNA 1.9 Inactive DFGinter None out-out out-out MMH Type1 126 - 394 T288D None 8
3K5UA 2.35 Inactive DFGinter None out-out out-out PFQ Type1 126 - 394 T288D None 9
4JBQA 2.3 Inactive DFGinter None out-out out-out VX6 Type1 126 - 391 T288D None 9
3LAUA 2.1 Inactive DFGinter None out-out none-none OFI Type1 125 - 391 T288D None 17
4UZHA 2.0 Inactive DFGinter None out-out none-none JVE Type1 125 - 392 None None 17
3H0YA 2.5 Inactive DFGinter None out-out none-none 48B Type1 126 - 388 K124A,T287A,T288A None 13
3H10A 2.2 Inactive DFGinter None out-out out-out 97B Type1 124 - 391 K124A,T287A,T288A None 0
3H10B 2.2 Inactive DFGinter None out-out out-out 97B Type1 125 - 391 K124A,T287A,T288A None 0
3H10D 2.2 Inactive DFGinter None out-out out-none 97B Type1 126 - 388 K124A,T287A,T288A None 8
3P9JA 2.8 Inactive DFGinter None out-out out-out P9J Type1 126 - 388 T287A,T288A None 11
3W10A 2.7 Inactive DFGinter None out-out out-out RO9 Type1 126 - 388 T287A,T288A None 0
3R22A 2.9 Inactive DFGinter None out-out out-out D37 Type1 126 - 389 T287D,T288D None 9
2BMCA 2.6 Inactive DFGinter None out-out out-none MPY Type1 127 - 394 None None 12
2BMCB 2.6 Inactive DFGinter None out-out out-none MPY Type1 125 - 394 None None 12
2BMCC 2.6 Inactive DFGinter None out-out out-none MPY Type1 125 - 393 None None 12
2BMCD 2.6 Inactive DFGinter None out-out out-none MPY Type1 127 - 394 None None 12
2BMCE 2.6 Inactive DFGinter None out-out out-none MPY Type1 127 - 394 None None 12
2BMCF 2.6 Inactive DFGinter None out-out out-none MPY Type1 126 - 394 None None 12
7FICA 2.32 Inactive DFGinter None out-none none-out 5YZ Type1 127 - 391 C290A None 11
5L8JA 1.68 Inactive DFGinter None out-out none-none ADP Type1 126 - 391 C290A,C393A X288 13
5L8KA 1.79 Inactive DFGinter None out-out out-out ADP Type1 126 - 392 C290A,C393A X288 0
5L8LA 1.67 Inactive DFGinter None out-out out-out ADP Type1 126 - 389 C290A,C393A X288 0
9BZGA 1.8 Inactive DFGinter None out-out out-out OG0 Type1 127 - 388 C290A,C393S X288 0
9BZLB 1.81 Inactive DFGinter None out-out out-out OGR Type1 127 - 388 C290A,C393S X288 0
8PR7A 2.76 Inactive DFGinter None out-out none-out ADP Type1 124 - 389 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None 13
4ZTQA 2.8 Inactive DFGinter None out-out out-out 4RM Type1.5_Back 127 - 388 None None 11
4ZTSA 2.9 Inactive DFGinter None out-out none-none 4RK Type1.5_Back 127 - 388 None None 13
3EFWA 2.29 Inactive DFGinter None out-none none-none AK8 Type1.5_Front 126 - 388 None None 17
3EFWB 2.29 Inactive DFGinter None out-out none-none AK8 Type1.5_Front 126 - 389 None None 17
3O50A 2.0 Inactive DFGinter None out-out none-none LJE Type1.5_Front 126 - 388 None None 14
3O50B 2.0 Inactive DFGinter None out-out none-out LJE Type1.5_Front 126 - 389 None None 11
6HJJA 2.13 Inactive DFGinter None out-out out-out G7T Type1.5_Front 127 - 393 L210C,C290A,C393A None 11
2C6EA 2.1 Inactive DFGout BBAminus out-out none-out HPM Type1.5_Back 127 - 389 None None 12
6VPJA 2.1 Inactive DFGout None out-out out-out ANP Type1 7 - 389 None None 3
4JAIA 3.2 Inactive DFGout None out-out none-none XU2 Type1 126 - 390 None None 16
7AYHA 2.8 Inactive DFGout None out-out none-none S9H Type1 125 - 390 None None 16
6VPHA 2.14 Inactive DFGout None out-out out-out ANP Type1 7 - 389 None X287,X288 0
7O2VA 3.1 Inactive DFGout None out-out out-out V0K Type1 117 - 390 None None 10
3O51A 3.2 Inactive DFGout None out-none none-none LJF Type1.5_Front 126 - 388 None None 17
6HJKA 2.4 Inactive DFGout None out-none out-out G7W Type1.5_Front 127 - 391 L210C,C290A,C393A None 10
5OBRA 2.62 Inactive None None out-out out-out 9QT SKE Allosteric Type1 126 - 390 None None 10
3W2CC 2.45 Inactive None None out-out none-none N15 Type1 128 - 388 None None 17
3W2CE 2.45 Inactive None None out-out none-none N15 Type1 128 - 388 None None 17
2X81A 2.91 Inactive None None out-none none-out ZZL Type1 127 - 388 None None 17
3W18A 2.5 Inactive None None out-out none-out N13 Type1 126 - 388 None None 17
3W18B 2.5 Inactive None None none-none none-out N13 Type1 126 - 388 None None 13
4B0GA 2.5 Inactive None None out-out out-none VEK Type1 126 - 391 None None 12
4BYJA 2.75 Inactive None None out-out none-none FH5 Type1 126 - 388 None None 17
6C83A 2.55 Inactive None None out-none none-out ACP Type1 127 - 389 None None 15
3H0ZB 2.92 Inactive None None out-out none-none 45B Type1 126 - 388 K124A,T287A,T288A None 17
3H0ZC 2.92 Inactive None None out-out none-none 45B Type1 126 - 388 K124A,T287A,T288A None 17
3COHA 2.7 Inactive None None out-out none-out 83H Type1 128 - 388 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None 14
3COHB 2.7 Inactive None None out-out none-out 83H Type1 128 - 388 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None 14
3QBNA 3.5 Inactive None None out-out none-out E9Z Type1 126 - 388 V279C,C290S,C393S None 13
2WQEA 2.5 Inactive None None out-none none-out ADP ADP ADP Type1 Type1 Type1 127 - 388 S155R None 16
3W2CA 2.45 Inactive None None out-out none-none N15 Type1.5_Back 128 - 388 None None 17
3W2CG 2.45 Inactive None None out-out none-none N15 Type1.5_Back 128 - 388 None None 17
2C6EB 2.1 Inactive None None out-out none-in HPM Type1.5_Front 127 - 388 None None 16

AURKA (Aurora kinase A)

Group: CAMK
Total number of chains: 239
Spatial Dihedral Chains Representative
DFGin BLAminus 107 AF-O14965-K1A
DFGin BLAplus 1 4J8MA
DFGin ABAminus 18 3E5AA
DFGin BLBminus 1 8PR7D
DFGin None 20 2J4ZB
DFGinter None 66 5L8LA
DFGout BBAminus 1 2C6EA
DFGout None 7 6VPHA
None None 18 5OBRA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens AURKA_HUMAN 5DPVA 2.285 Inactive DFGin ABAminus out-in in-out 5DN SKE Allosteric Type1 127 - 389 T287A None 6
Homo sapiens AURKA_HUMAN 5DR6A 2.534 Inactive DFGin ABAminus out-in in-out 5E1 SKE Allosteric Type1 127 - 390 T287A None 7
Homo sapiens AURKA_HUMAN 2WTWA 3.302 Inactive DFGin ABAminus out-out in-out ZZL Type1 128 - 389 L215R,T217E,R220K None 6
Homo sapiens AURKA_HUMAN 3E5AA 2.3 Inactive DFGin ABAminus out-out in-in VX6 Type1 125 - 389 None X288 0
Homo sapiens AURKA_HUMAN 2NP8A 2.25 Inactive DFGin ABAminus out-out out-none CC3 Type1 127 - 388 None None 6
Homo sapiens AURKA_HUMAN 4C3PD 2.69 Inactive DFGin ABAminus out-out in-out ACP Type1 125 - 390 None None 6
Homo sapiens AURKA_HUMAN 4BYIA 2.6 Inactive DFGin ABAminus out-out in-out FH3 Type1 126 - 388 None None 9
Homo sapiens AURKA_HUMAN 5ONEA 2.6 Inactive DFGin ABAminus out-out out-out 9YQ Type1 127 - 391 None None 8
Homo sapiens AURKA_HUMAN 5DT0A 2.15 Inactive DFGin ABAminus in-in in-out SKE Type1 127 - 390 None None 5
Homo sapiens AURKA_HUMAN 3UODA 2.5 Inactive DFGin ABAminus out-out in-out 0C3 Type1 124 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UP2A 2.3 Inactive DFGin ABAminus out-out in-out 0C8 Type1 124 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 4DEAA 2.45 Inactive DFGin ABAminus out-out in-out NHI Type1 124 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 5AAFA 2.78 Inactive DFGin ABAminus in-out in-out NL4 Type1 126 - 388 C290A,C393A None 9
Homo sapiens AURKA_HUMAN 5AAGA 2.85 Inactive DFGin ABAminus out-none in-out 6F2 Type1 127 - 388 C290A,C393A None 9
Homo sapiens AURKA_HUMAN 8GUWA 2.7 Inactive DFGin ABAminus out-out in-out ADP Type1 506 - 388 C290A,C393A None 7
Homo sapiens AURKA_HUMAN 8GUWB 2.7 Inactive DFGin ABAminus out-out none-none ADP Type1 507 - 390 C290A,C393A None 13
Homo sapiens AURKA_HUMAN 8GUWC 2.7 Inactive DFGin ABAminus out-out none-none ADP Type1 506 - 388 C290A,C393A None 14
Homo sapiens AURKA_HUMAN 6GRAA 2.6 Inactive DFGin ABAminus out-out none-none F8Z Type1.5_Front 126 - 389 None None 14
Homo sapiens AURKA_HUMAN 5DN3A 2.05 Inactive DFGin BLAminus in-in in-out 5DN ATP Allosteric Type1 125 - 389 None X288 0
Homo sapiens AURKA_HUMAN 8C1EA 2.798 Inactive DFGin BLAminus in-in in-out T0X ATP Allosteric Type1 127 - 388 None X288 0
Homo sapiens AURKA_HUMAN 5DT4A 2.86 Inactive DFGin BLAminus in-in in-out 5DN ATP Allosteric Type1 127 - 390 None None 5
Homo sapiens AURKA_HUMAN 8C1MA 2.84 Inactive DFGin BLAminus in-in in-out T4X ADP Allosteric Type1 127 - 389 None X288 0
Homo sapiens AURKA_HUMAN 8SSPA 2.6 Inactive DFGin BLAminus out-out in-in PDO 627 Allosteric Type1 126 - 389 None None 0
Homo sapiens AURKA_HUMAN 5DOSA 2.98 Inactive DFGin BLAminus in-in in-out 5DN ATP Allosteric Type1 127 - 390 T287A None 5
Homo sapiens AURKA_HUMAN 5DR2A 2.46 Inactive DFGin BLAminus in-in in-out 5E1 ATP Allosteric Type1 128 - 390 T287A None 0
Homo sapiens AURKA_HUMAN 8C1DA 2.115 Inactive DFGin BLAminus in-in in-out T2F ADP T5L Allosteric Type1 Allosteric 127 - 388 C290A None 3
Homo sapiens AURKA_HUMAN 8C1GA 1.96 Inactive DFGin BLAminus in-in in-out T3I ADP T5L Allosteric Type1 Allosteric 127 - 388 C290A None 4
Homo sapiens AURKA_HUMAN 8C1HA 2.233 Inactive DFGin BLAminus in-in in-out T3U ADP T5L Allosteric Type1 Allosteric 127 - 388 C290A None 4
Homo sapiens AURKA_HUMAN 8C1KA 2.43 Inactive DFGin BLAminus in-in in-out T4O ADP T5L Allosteric Type1 Allosteric 127 - 388 C290A None 0
Homo sapiens AURKA_HUMAN AF-O14965-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 125 - 391 None None 0
Homo sapiens AURKA_HUMAN 6CPEA 2.45 None DFGin BLAminus in-in in-none No_ligand No_ligand 127 - 389 None None 7
Homo sapiens AURKA_HUMAN 4J8NA 3.135 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 125 - 390 None None 0
Homo sapiens AURKA_HUMAN 4J8NB 3.135 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 125 - 390 None None 0
Homo sapiens AURKA_HUMAN 4J8NC 3.135 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 125 - 390 None None 0
Homo sapiens AURKA_HUMAN 4J8ND 3.135 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 126 - 390 None None 0
Homo sapiens AURKA_HUMAN 4BN1A 2.499 Inactive DFGin BLAminus in-in in-out ADP Type1 126 - 388 V174M X287,X288 0
Homo sapiens AURKA_HUMAN 8JG8A 2.9 Inactive DFGin BLAminus out-out in-out C74 Type1 127 - 389 None None 8
Homo sapiens AURKA_HUMAN 3HA6A 2.36 Inactive DFGin BLAminus in-out in-in 2JZ Type1 125 - 388 None X287,X288 0
Homo sapiens AURKA_HUMAN 1MQ4A 1.9 Inactive DFGin BLAminus in-in in-out ADP Type1 126 - 388 None None 2
Homo sapiens AURKA_HUMAN 3MYGA 2.4 None DFGin BLAminus in-in in-none EML Type1 126 - 388 None None 11
Homo sapiens AURKA_HUMAN 3VAPA 2.66 None DFGin BLAminus in-in none-out 0FY Type1 127 - 388 None None 13
Homo sapiens AURKA_HUMAN 5DNRA 1.95 Inactive DFGin BLAminus in-in in-out ATP Type1 126 - 390 None X288 0
Homo sapiens AURKA_HUMAN 5DT3A 2.33 Inactive DFGin BLAminus in-in in-out ATP Type1 127 - 390 None X287 0
Homo sapiens AURKA_HUMAN 2W1CA 3.24 Inactive DFGin BLAminus out-out in-out L0C Type1 127 - 389 None X287,X288 0
Homo sapiens AURKA_HUMAN 2W1DA 2.97 Inactive DFGin BLAminus in-out in-out L0D Type1 127 - 389 None None 11
Homo sapiens AURKA_HUMAN 2W1EA 2.93 Inactive DFGin BLAminus out-out in-out L0E Type1 127 - 389 None None 11
Homo sapiens AURKA_HUMAN 2W1FA 2.85 Inactive DFGin BLAminus out-out in-out L0F Type1 127 - 389 None None 10
Homo sapiens AURKA_HUMAN 2W1GA 2.71 Inactive DFGin BLAminus in-out in-out L0G Type1 127 - 389 None X287,X288 9
Homo sapiens AURKA_HUMAN 5ZANA 2.85 None DFGin BLAminus out-none in-out 9A6 Type1 127 - 389 None None 5
Homo sapiens AURKA_HUMAN 1OL5A 2.5 Active DFGin BLAminus in-in in-in ADP Type1 123 - 388 None X287,X288 0
Homo sapiens AURKA_HUMAN 1OL7A 2.75 Inactive DFGin BLAminus in-in in-out ADP Type1 127 - 390 None X287,X288 0
Homo sapiens AURKA_HUMAN 4O0SA 2.5 Inactive DFGin BLAminus out-out in-out ADN Type1 126 - 391 None None 1
Homo sapiens AURKA_HUMAN 5G15A 2.06 Inactive DFGin BLAminus out-out in-in ACP Type1 126 - 390 None None 0
Homo sapiens AURKA_HUMAN 2XNGA 2.605 None DFGin BLAminus in-out in-none A0H Type1 127 - 390 None None 10
Homo sapiens AURKA_HUMAN 4JAJA 2.7 Inactive DFGin BLAminus in-in in-out XU1 Type1 125 - 389 None None 0
Homo sapiens AURKA_HUMAN 2DWBA 2.5 Inactive DFGin BLAminus in-in in-out ANP Type1 126 - 389 None None 2
Homo sapiens AURKA_HUMAN 2X6DA 2.796 Inactive DFGin BLAminus in-out in-out X6D Type1 126 - 388 None None 4
Homo sapiens AURKA_HUMAN 2X6EA 3.35 None DFGin BLAminus in-out in-none YM4 Type1 126 - 388 None None 11
Homo sapiens AURKA_HUMAN 4ZS0A 3.0 None DFGin BLAminus out-out in-none 4QV Type1 127 - 388 None None 5
Homo sapiens AURKA_HUMAN 6I2UA 2.5 Inactive DFGin BLAminus in-in in-out COA Type1 127 - 391 None X287,X288 0
Homo sapiens AURKA_HUMAN 6CPFA 2.3 None DFGin BLAminus out-none in-out ACP Type1 128 - 392 None None 6
Homo sapiens AURKA_HUMAN 6VPGA 2.64 Active DFGin BLAminus in-in in-in ANP Type1 104 - 389 None X287,X288 0
Homo sapiens AURKA_HUMAN 5DRDA 2.13 Inactive DFGin BLAminus in-in in-out ATP Type1 127 - 390 T287A None 5
Homo sapiens AURKA_HUMAN 2XRUA 2.9 Inactive DFGin BLAminus in-out in-out 400 Type1 126 - 389 T288E None 10
Homo sapiens AURKA_HUMAN 3UO4A 2.45 Inactive DFGin BLAminus out-out in-out 0C0 Type1 124 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UO5A 2.701 Inactive DFGin BLAminus in-out in-out 0BX Type1 124 - 390 T287D None 0
Homo sapiens AURKA_HUMAN 3UP7A 3.05 Inactive DFGin BLAminus in-out in-out 0C9 Type1 124 - 387 T287D None 0
Homo sapiens AURKA_HUMAN 4DEBA 3.05 Inactive DFGin BLAminus out-out in-out NHJ Type1 125 - 388 T287D None 0
Homo sapiens AURKA_HUMAN 4DEDA 3.05 Inactive DFGin BLAminus in-out in-out NHU Type1 124 - 388 T287D None 0
Homo sapiens AURKA_HUMAN 4DEEA 2.3 Inactive DFGin BLAminus in-in in-out ADP Type1 124 - 394 T287D None 0
Homo sapiens AURKA_HUMAN 6VPIA 2.0 Inactive DFGin BLAminus in-in in-out ANP Type1 7 - 389 None None 0
Homo sapiens AURKA_HUMAN 4JBOA 2.493 Inactive DFGin BLAminus out-out in-out WPH Type1 126 - 391 T288D None 0
Homo sapiens AURKA_HUMAN 3NRMA 3.05 Inactive DFGin BLAminus in-in in-out NRM Type1 126 - 388 T287A,T288A None 0
Homo sapiens AURKA_HUMAN 3R21A 2.9 Inactive DFGin BLAminus out-out in-out D36 Type1 127 - 389 T287D,T288D None 9
Homo sapiens AURKA_HUMAN 5LXMA 2.08 Active DFGin BLAminus in-in in-in ADP Type1 126 - 392 C290A,C393A X288 0
Homo sapiens AURKA_HUMAN 4CEGA 2.1 Inactive DFGin BLAminus in-in in-out ADP Type1 127 - 391 C290A,C393A X288 0
Homo sapiens AURKA_HUMAN 5AADA 3.1 None DFGin BLAminus in-in in-none 5GX Type1 127 - 388 C290A,C393A None 10
Homo sapiens AURKA_HUMAN 5G1XA 1.72 Active DFGin BLAminus in-in in-in ADP Type1 126 - 389 C290A,C393A X288 0
Homo sapiens AURKA_HUMAN 2XNEA 2.8 None DFGin BLAminus out-out in-none ASH Type1 127 - 388 D274N None 9
Homo sapiens AURKA_HUMAN 1OL6A 3.0 None DFGin BLAminus in-out in-none ATP Type1 128 - 388 D274N None 11
Homo sapiens AURKA_HUMAN 6VPLA 1.86 Inactive DFGin BLAminus out-out in-out ANP R7D Type1 Allosteric 7 - 389 None X288 4
Homo sapiens AURKA_HUMAN 6VPLB 1.86 Inactive DFGin BLAminus out-out in-out ANP R7D Type1 Allosteric 7 - 389 None X288 4
Homo sapiens AURKA_HUMAN 6VPMA 1.58 Inactive DFGin BLAminus out-out in-out AMP R74 Type1 Allosteric 7 - 389 None X288 4
Homo sapiens AURKA_HUMAN 6VPMB 1.58 Inactive DFGin BLAminus out-out in-out AMP R74 Type1 Allosteric 7 - 389 None X288 4
Homo sapiens AURKA_HUMAN 5DR9A 2.47 Inactive DFGin BLAminus out-out out-out SKE 5E2 Type1 Allosteric 127 - 390 T287A None 7
Homo sapiens AURKA_HUMAN 5ORLA 1.69 Inactive DFGin BLAminus in-in in-out ADP A4W Type1 Allosteric 127 - 391 C290A X288 0
Homo sapiens AURKA_HUMAN 5ORNA 2.19 Inactive DFGin BLAminus in-in in-out ADP A5E Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OROA 2.12 Inactive DFGin BLAminus in-in in-out ADP A5H Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORPA 2.19 Inactive DFGin BLAminus in-in in-out ADP A5K Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORRA 2.09 Inactive DFGin BLAminus in-in in-out ADP A5Q Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORSA 1.98 Inactive DFGin BLAminus in-in in-out ADP A5W Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORTA 2.56 Inactive DFGin BLAminus in-in in-out ADP A5Z Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORVA 1.88 Inactive DFGin BLAminus in-in in-out ADP A65 Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORWA 2.0 Inactive DFGin BLAminus in-in in-out ADP A6E Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORXA 1.88 Inactive DFGin BLAminus in-in in-out ADP A6H Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORYA 1.99 Inactive DFGin BLAminus in-in in-out ADP AY4 Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5ORZA 1.92 Inactive DFGin BLAminus in-in in-out ADP A6W Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OS0A 1.74 Inactive DFGin BLAminus in-in in-out ADP A6Z Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OS1A 1.9 Inactive DFGin BLAminus in-in in-out ADP A7H Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OS2A 1.92 Inactive DFGin BLAminus in-in in-out ADP A7K Type1 Allosteric 127 - 391 None None 4
Homo sapiens AURKA_HUMAN 5OS3A 1.81 Inactive DFGin BLAminus in-in in-out ADP A7N Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OS4A 1.88 Inactive DFGin BLAminus in-in in-out ADP A8H Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OS6A 2.2 Inactive DFGin BLAminus in-in in-out ADP A7Q Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OSEA 1.9 Inactive DFGin BLAminus in-in in-out ADP A98 Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OSFA 1.89 Inactive DFGin BLAminus in-in in-out ADP A9E Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OSDA 1.99 Inactive DFGin BLAminus in-in in-out ADP A9B Type1 Allosteric 125 - 391 None X288 0
Homo sapiens AURKA_HUMAN 5OS5A 1.74 Inactive DFGin BLAminus in-in in-out ADP A8K Type1 Allosteric 125 - 392 None X288 0
Homo sapiens AURKA_HUMAN 6R49A 2.209 Inactive DFGin BLAminus in-in in-out ADP JSB Type1 Allosteric 127 - 391 C290A,C393A X288 5
Homo sapiens AURKA_HUMAN 6R4AA 1.937 Inactive DFGin BLAminus in-in in-out ADP JRT Type1 Allosteric 127 - 391 C290A,C393A X288 0
Homo sapiens AURKA_HUMAN 6R4BA 2.15 Inactive DFGin BLAminus in-in in-out ADP JSN Type1 Allosteric 127 - 391 None X288 0
Homo sapiens AURKA_HUMAN 6R4CA 2.04 Inactive DFGin BLAminus in-in in-out ADP JRQ Type1 Allosteric 127 - 391 C290A,C393A X288 0
Homo sapiens AURKA_HUMAN 6R4DA 2.009 Inactive DFGin BLAminus in-in in-out ADP JRW Type1 Allosteric 127 - 391 C290A,C393A X288 0
Homo sapiens AURKA_HUMAN 7ZTLA 1.9 Active DFGin BLAminus in-in in-in ADP BCN Type1 Allosteric 126 - 389 C290A,K339C,C393A X288 0
Homo sapiens AURKA_HUMAN 8OF5A 1.97 Inactive DFGin BLAminus in-in in-out ADP MPO Type1 Allosteric 126 - 390 C290A,N332A,Q335A,C393A None 0
Homo sapiens AURKA_HUMAN 8C14A 1.93 Inactive DFGin BLAminus in-in in-out ADP T5L T0L Type1 Allosteric Allosteric 126 - 389 None X288 0
Homo sapiens AURKA_HUMAN 8C15A 2.41 Inactive DFGin BLAminus in-in in-out ADP T4C T5L Type1 Allosteric Allosteric 126 - 388 C290A None 4
Homo sapiens AURKA_HUMAN 8C1FA 1.924 Inactive DFGin BLAminus in-in in-out ADP T5L T2O Type1 Allosteric Allosteric 126 - 388 C290A None 5
Homo sapiens AURKA_HUMAN 8C1IA 2.81 Inactive DFGin BLAminus in-in in-out ADP T1L T5L Type1 Allosteric Allosteric 126 - 388 C290A None 3
Homo sapiens AURKA_HUMAN 3M11A 2.75 Inactive DFGin BLAminus out-out in-out AKI Type1.5_Front 126 - 391 T288D None 10
Homo sapiens AURKA_HUMAN 4JBPA 2.45 Inactive DFGin BLAminus out-out in-out YPH Type1.5_Front 126 - 390 T288D None 10
Homo sapiens AURKA_HUMAN 4J8MA 1.853 Inactive DFGin BLAplus out-out out-out CJ5 Type1 125 - 390 T287D None 0
Homo sapiens AURKA_HUMAN 8PR7D 2.76 Inactive DFGin BLBminus out-none none-out ADP Type1 126 - 388 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None 12
Homo sapiens AURKA_HUMAN 8JF4A 2.893 Inactive DFGin None out-none none-out C0N Type1 127 - 389 None None 11
Homo sapiens AURKA_HUMAN 8JMXA 2.95 Inactive DFGin None out-none none-out E47 Type1 127 - 389 None None 13
Homo sapiens AURKA_HUMAN 4C3PA 2.69 Inactive DFGin None out-out in-out ACP Type1 125 - 388 None None 0
Homo sapiens AURKA_HUMAN 7AYIA 2.86 Inactive DFGin None out-out none-none S9K Type1 125 - 392 None None 16
Homo sapiens AURKA_HUMAN 2J4ZB 2.0 Inactive DFGin None out-out out-out 626 Type1 126 - 395 None None 0
Homo sapiens AURKA_HUMAN 4O0WA 2.6 Inactive DFGin None out-out in-out ADN Type1 125 - 391 H254Y None 8
Homo sapiens AURKA_HUMAN 2C6DA 2.2 Inactive DFGin None out-out out-out ANP Type1 126 - 390 None None 10
Homo sapiens AURKA_HUMAN 3H0ZA 2.92 Inactive DFGin None out-out none-none 45B Type1 128 - 388 K124A,T287A,T288A None 13
Homo sapiens AURKA_HUMAN 4DHFA 2.8 Inactive DFGin None in-in in-out 0K6 Type1 128 - 389 T287D,T288D None 4
Homo sapiens AURKA_HUMAN 4DHFB 2.8 Inactive DFGin None in-in in-out 0K6 Type1 128 - 389 T287D,T288D None 4
Homo sapiens AURKA_HUMAN 4PRJA 2.8 Inactive DFGin None in-in in-out 2VU Type1 125 - 388 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None 10
Homo sapiens AURKA_HUMAN 5AAEA 3.11 Inactive DFGin None out-none in-out 7HD Type1 126 - 388 C290A,C393A None 11
Homo sapiens AURKA_HUMAN 4O0UA 2.6 Inactive DFGin None out-out in-out ADN Type1 126 - 391 H254R None 7
Homo sapiens AURKA_HUMAN 5ODTA 2.021 Inactive DFGin None out-out out-out ADP Type1 126 - 392 D274N,C290A,C393A None 9
Homo sapiens AURKA_HUMAN 5OBJA 2.901 Inactive DFGin None out-out in-out ATP 9QK Type1 Allosteric 127 - 390 None None 4
Homo sapiens AURKA_HUMAN 4UZDA 3.2 Inactive DFGin None out-out none-out QMN Type1.5_Front 127 - 388 None None 8
Homo sapiens AURKA_HUMAN 4UZDB 3.2 Inactive DFGin None out-out none-out QMN Type1.5_Front 125 - 389 None None 7
Homo sapiens AURKA_HUMAN 4UYNA 1.9 Inactive DFGin None out-out none-none Y3M Type1.5_Front 125 - 391 None None 16
Homo sapiens AURKA_HUMAN 6XKAA 2.65 Inactive DFGinter None out-out out-out No_ligand No_ligand 127 - 388 None None 10
Homo sapiens AURKA_HUMAN 2WTVA 2.4 Inactive DFGinter None out-out out-out ZZL Type1 125 - 389 L215R,T217E,R220K X287,X288 0
Homo sapiens AURKA_HUMAN 2WTVB 2.4 Inactive DFGinter None out-out out-out ZZL Type1 126 - 389 L215R,T217E,R220K X287,X288 0
Homo sapiens AURKA_HUMAN 2WTVC 2.4 Inactive DFGinter None out-out out-out ZZL Type1 126 - 389 L215R,T217E,R220K X287,X288 0
Homo sapiens AURKA_HUMAN 2WTVD 2.4 Inactive DFGinter None out-out out-out ZZL Type1 125 - 389 L215R,T217E,R220K X287,X288 0
Homo sapiens AURKA_HUMAN 5EW9A 2.181 Inactive DFGinter None out-out out-out 5VC Type1 127 - 390 None X287,X288 5
Homo sapiens AURKA_HUMAN 6C2RA 1.96 Inactive DFGinter None out-none out-none EG7 Type1 128 - 389 None None 12
Homo sapiens AURKA_HUMAN 6C2TA 1.73 Inactive DFGinter None out-out out-out EGJ Type1 128 - 388 None None 8
Homo sapiens AURKA_HUMAN 3W16A 2.8 Inactive DFGinter None out-out out-out P9J Type1 126 - 388 None None 11
Homo sapiens AURKA_HUMAN 2J50A 3.0 Inactive DFGinter None out-out out-out 627 Type1 128 - 389 None None 8
Homo sapiens AURKA_HUMAN 2J50B 3.0 Inactive DFGinter None out-out out-out 627 Type1 128 - 389 None None 8
Homo sapiens AURKA_HUMAN 4C3RA 2.79 Inactive DFGinter None out-out out-out ACP Type1 127 - 388 None None 10
Homo sapiens AURKA_HUMAN 4ZTRA 2.85 Inactive DFGinter None out-out none-out 4RJ Type1 127 - 388 None None 13
Homo sapiens AURKA_HUMAN 6Z4YA 2.25 Inactive DFGinter None out-out out-out Q7Q Type1 124 - 389 None None 7
Homo sapiens AURKA_HUMAN 6C83B 2.55 Inactive DFGinter None out-out none-out ACP Type1 127 - 388 None None 15
Homo sapiens AURKA_HUMAN 6CPGA 2.8 Inactive DFGinter None out-out none-out 35R Type1 127 - 387 None None 12
Homo sapiens AURKA_HUMAN 6CPGD 2.8 Inactive DFGinter None out-out none-out 35R Type1 127 - 388 None None 10
Homo sapiens AURKA_HUMAN 8SSOA 1.97 Inactive DFGinter None out-out out-out 627 Type1 127 - 389 None None 7
Homo sapiens AURKA_HUMAN 8SSOD 1.97 Inactive DFGinter None out-out out-none 627 Type1 127 - 389 None None 11
Homo sapiens AURKA_HUMAN 1MUOA 2.9 Inactive DFGinter None out-out none-out ADN Type1 128 - 388 None None 10
Homo sapiens AURKA_HUMAN 2J4ZA 2.0 Inactive DFGinter None out-out out-out 626 Type1 126 - 389 None None 0
Homo sapiens AURKA_HUMAN 3UNZA 2.8 Inactive DFGinter None out-out out-out 0BZ Type1 127 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UNZB 2.8 Inactive DFGinter None out-out out-out 0BZ Type1 127 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UO6A 2.8 Inactive DFGinter None out-out out-out 0BY Type1 126 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UO6B 2.8 Inactive DFGinter None out-out out-out 0BY Type1 126 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UOHA 2.8 Inactive DFGinter None out-out out-out 0C4 Type1 126 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UOHB 2.8 Inactive DFGinter None out-out out-out 0C4 Type1 126 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UOJA 2.9 Inactive DFGinter None out-out out-out 0C5 Type1 127 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UOJB 2.9 Inactive DFGinter None out-out out-out 0C5 Type1 127 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UOKA 2.951 Inactive DFGinter None out-out out-out 0C6 Type1 125 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UOKB 2.951 Inactive DFGinter None out-out out-out 0C6 Type1 125 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UOLA 2.4 Inactive DFGinter None out-out out-out 0C7 Type1 127 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3UOLB 2.4 Inactive DFGinter None out-out out-out 0C7 Type1 127 - 389 T287D None 0
Homo sapiens AURKA_HUMAN 3FDNA 1.9 Inactive DFGinter None out-out out-out MMH Type1 126 - 394 T288D None 8
Homo sapiens AURKA_HUMAN 3K5UA 2.35 Inactive DFGinter None out-out out-out PFQ Type1 126 - 394 T288D None 9
Homo sapiens AURKA_HUMAN 4JBQA 2.3 Inactive DFGinter None out-out out-out VX6 Type1 126 - 391 T288D None 9
Homo sapiens AURKA_HUMAN 3LAUA 2.1 Inactive DFGinter None out-out none-none OFI Type1 125 - 391 T288D None 17
Homo sapiens AURKA_HUMAN 4UZHA 2.0 Inactive DFGinter None out-out none-none JVE Type1 125 - 392 None None 17
Homo sapiens AURKA_HUMAN 3H0YA 2.5 Inactive DFGinter None out-out none-none 48B Type1 126 - 388 K124A,T287A,T288A None 13
Homo sapiens AURKA_HUMAN 3H10A 2.2 Inactive DFGinter None out-out out-out 97B Type1 124 - 391 K124A,T287A,T288A None 0
Homo sapiens AURKA_HUMAN 3H10B 2.2 Inactive DFGinter None out-out out-out 97B Type1 125 - 391 K124A,T287A,T288A None 0
Homo sapiens AURKA_HUMAN 3H10D 2.2 Inactive DFGinter None out-out out-none 97B Type1 126 - 388 K124A,T287A,T288A None 8
Homo sapiens AURKA_HUMAN 3P9JA 2.8 Inactive DFGinter None out-out out-out P9J Type1 126 - 388 T287A,T288A None 11
Homo sapiens AURKA_HUMAN 3W10A 2.7 Inactive DFGinter None out-out out-out RO9 Type1 126 - 388 T287A,T288A None 0
Homo sapiens AURKA_HUMAN 3R22A 2.9 Inactive DFGinter None out-out out-out D37 Type1 126 - 389 T287D,T288D None 9
Homo sapiens AURKA_HUMAN 2BMCA 2.6 Inactive DFGinter None out-out out-none MPY Type1 127 - 394 None None 12
Homo sapiens AURKA_HUMAN 2BMCB 2.6 Inactive DFGinter None out-out out-none MPY Type1 125 - 394 None None 12
Homo sapiens AURKA_HUMAN 2BMCC 2.6 Inactive DFGinter None out-out out-none MPY Type1 125 - 393 None None 12
Homo sapiens AURKA_HUMAN 2BMCD 2.6 Inactive DFGinter None out-out out-none MPY Type1 127 - 394 None None 12
Homo sapiens AURKA_HUMAN 2BMCE 2.6 Inactive DFGinter None out-out out-none MPY Type1 127 - 394 None None 12
Homo sapiens AURKA_HUMAN 2BMCF 2.6 Inactive DFGinter None out-out out-none MPY Type1 126 - 394 None None 12
Homo sapiens AURKA_HUMAN 7FICA 2.32 Inactive DFGinter None out-none none-out 5YZ Type1 127 - 391 C290A None 11
Homo sapiens AURKA_HUMAN 5L8JA 1.68 Inactive DFGinter None out-out none-none ADP Type1 126 - 391 C290A,C393A X288 13
Homo sapiens AURKA_HUMAN 5L8KA 1.79 Inactive DFGinter None out-out out-out ADP Type1 126 - 392 C290A,C393A X288 0
Homo sapiens AURKA_HUMAN 5L8LA 1.67 Inactive DFGinter None out-out out-out ADP Type1 126 - 389 C290A,C393A X288 0
Homo sapiens AURKA_HUMAN 9BZGA 1.8 Inactive DFGinter None out-out out-out OG0 Type1 127 - 388 C290A,C393S X288 0
Homo sapiens AURKA_HUMAN 9BZLB 1.81 Inactive DFGinter None out-out out-out OGR Type1 127 - 388 C290A,C393S X288 0
Homo sapiens AURKA_HUMAN 8PR7A 2.76 Inactive DFGinter None out-out none-out ADP Type1 124 - 389 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None 13
Homo sapiens AURKA_HUMAN 4ZTQA 2.8 Inactive DFGinter None out-out out-out 4RM Type1.5_Back 127 - 388 None None 11
Homo sapiens AURKA_HUMAN 4ZTSA 2.9 Inactive DFGinter None out-out none-none 4RK Type1.5_Back 127 - 388 None None 13
Homo sapiens AURKA_HUMAN 3EFWA 2.29 Inactive DFGinter None out-none none-none AK8 Type1.5_Front 126 - 388 None None 17
Homo sapiens AURKA_HUMAN 3EFWB 2.29 Inactive DFGinter None out-out none-none AK8 Type1.5_Front 126 - 389 None None 17
Homo sapiens AURKA_HUMAN 3O50A 2.0 Inactive DFGinter None out-out none-none LJE Type1.5_Front 126 - 388 None None 14
Homo sapiens AURKA_HUMAN 3O50B 2.0 Inactive DFGinter None out-out none-out LJE Type1.5_Front 126 - 389 None None 11
Homo sapiens AURKA_HUMAN 6HJJA 2.13 Inactive DFGinter None out-out out-out G7T Type1.5_Front 127 - 393 L210C,C290A,C393A None 11
Homo sapiens AURKA_HUMAN 2C6EA 2.1 Inactive DFGout BBAminus out-out none-out HPM Type1.5_Back 127 - 389 None None 12
Homo sapiens AURKA_HUMAN 6VPJA 2.1 Inactive DFGout None out-out out-out ANP Type1 7 - 389 None None 3
Homo sapiens AURKA_HUMAN 4JAIA 3.2 Inactive DFGout None out-out none-none XU2 Type1 126 - 390 None None 16
Homo sapiens AURKA_HUMAN 7AYHA 2.8 Inactive DFGout None out-out none-none S9H Type1 125 - 390 None None 16
Homo sapiens AURKA_HUMAN 6VPHA 2.14 Inactive DFGout None out-out out-out ANP Type1 7 - 389 None X287,X288 0
Homo sapiens AURKA_HUMAN 7O2VA 3.1 Inactive DFGout None out-out out-out V0K Type1 117 - 390 None None 10
Homo sapiens AURKA_HUMAN 3O51A 3.2 Inactive DFGout None out-none none-none LJF Type1.5_Front 126 - 388 None None 17
Homo sapiens AURKA_HUMAN 6HJKA 2.4 Inactive DFGout None out-none out-out G7W Type1.5_Front 127 - 391 L210C,C290A,C393A None 10
Homo sapiens AURKA_HUMAN 5OBRA 2.62 Inactive None None out-out out-out 9QT SKE Allosteric Type1 126 - 390 None None 10
Homo sapiens AURKA_HUMAN 3W2CC 2.45 Inactive None None out-out none-none N15 Type1 128 - 388 None None 17
Homo sapiens AURKA_HUMAN 3W2CE 2.45 Inactive None None out-out none-none N15 Type1 128 - 388 None None 17
Homo sapiens AURKA_HUMAN 2X81A 2.91 Inactive None None out-none none-out ZZL Type1 127 - 388 None None 17
Homo sapiens AURKA_HUMAN 3W18A 2.5 Inactive None None out-out none-out N13 Type1 126 - 388 None None 17
Homo sapiens AURKA_HUMAN 3W18B 2.5 Inactive None None none-none none-out N13 Type1 126 - 388 None None 13
Homo sapiens AURKA_HUMAN 4B0GA 2.5 Inactive None None out-out out-none VEK Type1 126 - 391 None None 12
Homo sapiens AURKA_HUMAN 4BYJA 2.75 Inactive None None out-out none-none FH5 Type1 126 - 388 None None 17
Homo sapiens AURKA_HUMAN 6C83A 2.55 Inactive None None out-none none-out ACP Type1 127 - 389 None None 15
Homo sapiens AURKA_HUMAN 3H0ZB 2.92 Inactive None None out-out none-none 45B Type1 126 - 388 K124A,T287A,T288A None 17
Homo sapiens AURKA_HUMAN 3H0ZC 2.92 Inactive None None out-out none-none 45B Type1 126 - 388 K124A,T287A,T288A None 17
Homo sapiens AURKA_HUMAN 3COHA 2.7 Inactive None None out-out none-out 83H Type1 128 - 388 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None 14
Homo sapiens AURKA_HUMAN 3COHB 2.7 Inactive None None out-out none-out 83H Type1 128 - 388 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None 14
Homo sapiens AURKA_HUMAN 3QBNA 3.5 Inactive None None out-out none-out E9Z Type1 126 - 388 V279C,C290S,C393S None 13
Homo sapiens AURKA_HUMAN 2WQEA 2.5 Inactive None None out-none none-out ADP ADP ADP Type1 Type1 Type1 127 - 388 S155R None 16
Homo sapiens AURKA_HUMAN 3W2CA 2.45 Inactive None None out-out none-none N15 Type1.5_Back 128 - 388 None None 17
Homo sapiens AURKA_HUMAN 3W2CG 2.45 Inactive None None out-out none-none N15 Type1.5_Back 128 - 388 None None 17
Homo sapiens AURKA_HUMAN 2C6EB 2.1 Inactive None None out-out none-in HPM Type1.5_Front 127 - 388 None None 16
Mus musculus AURKA_MOUSE 3D14A 1.9 Inactive DFGin BLAminus out-out in-out AK1 Type1.5_Front 117 - 379 N164G,K218R,M280L None 6
Mus musculus AURKA_MOUSE 3D15A 2.3 Inactive DFGin BLAminus out-out in-out AK2 Type1.5_Front 117 - 379 N164G,K218R,M280L None 7
Mus musculus AURKA_MOUSE 3D2IA 2.9 Inactive DFGin BLAminus out-out in-out AK3 Type1.5_Front 118 - 379 N164G,K218R,M280L None 7
Mus musculus AURKA_MOUSE 3D2KA 2.5 None DFGin BLAminus out-out in-none AK4 Type1.5_Front 119 - 379 N164G,K218R,M280L None 11
Mus musculus AURKA_MOUSE 3DJ7A 2.8 Inactive DFGin BLAminus out-out in-out AK7 Type1.5_Front 117 - 379 N164G,K218R,M280L None 6
Mus musculus AURKA_MOUSE 3DJ5A 1.8 Inactive DFGin None out-out none-out AK5 Type1.5_Front 119 - 379 N164G,K218R,M280L None 9
Mus musculus AURKA_MOUSE 3DJ6A 1.7 Inactive DFGin None out-out none-out AK6 Type1.5_Front 119 - 379 N164G,K218R,M280L None 9
Mus musculus AURKA_MOUSE 3DAJA 2.0 Inactive DFGinter None out-out none-none FXG Type1 118 - 379 N164G,K218R,T278D,M280L None 13

AURKA (Aurora kinase A)

Group: CAMK
Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 5 3D14A
DFGin None 2 3DJ6A
DFGinter None 1 3DAJA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus AURKA_MOUSE 3D14A 1.9 Inactive DFGin BLAminus out-out in-out AK1 Type1.5_Front 117 - 379 N164G,K218R,M280L None 6
Mus musculus AURKA_MOUSE 3D15A 2.3 Inactive DFGin BLAminus out-out in-out AK2 Type1.5_Front 117 - 379 N164G,K218R,M280L None 7
Mus musculus AURKA_MOUSE 3D2IA 2.9 Inactive DFGin BLAminus out-out in-out AK3 Type1.5_Front 118 - 379 N164G,K218R,M280L None 7
Mus musculus AURKA_MOUSE 3D2KA 2.5 None DFGin BLAminus out-out in-none AK4 Type1.5_Front 119 - 379 N164G,K218R,M280L None 11
Mus musculus AURKA_MOUSE 3DJ7A 2.8 Inactive DFGin BLAminus out-out in-out AK7 Type1.5_Front 117 - 379 N164G,K218R,M280L None 6
Mus musculus AURKA_MOUSE 3DJ5A 1.8 Inactive DFGin None out-out none-out AK5 Type1.5_Front 119 - 379 N164G,K218R,M280L None 9
Mus musculus AURKA_MOUSE 3DJ6A 1.7 Inactive DFGin None out-out none-out AK6 Type1.5_Front 119 - 379 N164G,K218R,M280L None 9
Mus musculus AURKA_MOUSE 3DAJA 2.0 Inactive DFGinter None out-out none-none FXG Type1 118 - 379 N164G,K218R,T278D,M280L None 13