OTHER_ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

Total number of chains: 50
Active chains: 8
Family: OTHER
Uniprot: ERN1_HUMAN
Kinase Domain Residues: 569 - 832
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 56.0% AF-O75460-K1A
DFGin BLBplus 13 26.0% 3P23C
DFGin None 3 6.0% 4Z7HA
DFGout None 3 6.0% 4YZ9A
None None 2 4.0% 6HX1A
DFGin ABAminus 1 2.0% 4Z7HB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-O75460-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 561 - 840 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
AF-O75460-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 561 - 840 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3CA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 560 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3CB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3CC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3CD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
9GOWA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IOO Type1 562 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
9GOWC 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IOO Type1 562 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
4Z7HB 2.9 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nioi 4L5 Type1 562 - 962 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
5HGIA 2.584 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6XDFB 2.54 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnio No_ligand No_ligand 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3BA 2.57 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
9GOWB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1IOO Type1 562 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
9GOWD 3.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii A1IOO Type1 562 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3EB 2.737 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaooi APEdist_nnoo SJV Type1.5_Back 563 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
6XDFA 2.54 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi N94 Type1.5_Back 560 - 966 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
7BMKA 1.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi U4N Type1.5_Back 561 - 966 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
7BMKB 1.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_ioio U4N Type1.5_Back 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6URCA 2.2 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi QFV Type1.5_Back 560 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6URCB 2.2 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi QFV Type1.5_Back 560 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6XDDB 2.4 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii N97 Type1.5_Back 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
4U6RA 2.5 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iioi 3E4 Type1.5_Back 561 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6XDBA 2.45 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi N8S Type1.5_Back 561 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3EA 2.737 Inactive DFGin‑BLAminus out-out none-none nonTYR APEdihe_aannn APEdist_nnnn SJV Type1.5_Front 562 - 962 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
6XDDA 2.4 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiio APEdist_oiio N97 Type1.5_Front 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
8UVLA 2.43 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi XOE Type1.5_Front 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4YZDA 3.102 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4YZDB 3.102 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_niii ADP ATPlike 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4YZDC 3.102 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_niii ADP ATPlike 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
3P23A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
3P23B 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoi ADP ATPlike 564 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
3P23C 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_iioi ADP ATPlike 561 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
3P23D 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_nnoi ADP ATPlike 561 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
9N88A 2.6 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
9N88E 2.6 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6W39A 1.736 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoo APEdist_nnnn SJG Type1 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6W39B 1.736 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoo APEdist_nnnn SJG Type1 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3AA 2.606 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaooo APEdist_nnno SJM Type1 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3AB 2.606 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaooo APEdist_nnno SJM Type1 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4Z7GA 2.6 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnni No_ligand No_ligand 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4Z7GB 2.6 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnni No_ligand No_ligand 562 - 962 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4Z7HA 2.9 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi 4L5 Type1 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4YZ9A 2.463 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 4K7 Type3 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4YZ9B 2.463 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 4K7 Type3 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4YZ9C 2.463 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 4K7 Type3 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6HX1A 2.14 Inactive None‑None none-none out-out nonTYR APEdihe_aaooi APEdist_iioo GXK Type1 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
6HV0A 2.73 Inactive None‑None none-none out-out nonTYR APEdihe_aaoii APEdist_iioo GUK Type1 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
4YZCA 2.494 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 562 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
4YZCB 2.494 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 562 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
6W3KA 2.08 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii SJS Type1 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1

OTHER_ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

Total number of chains: 60
Active chains: 8
Family: OTHER
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 46.7% AF-O75460-K1A
DFGin BLBplus 23 38.3% 3P23C
DFGin None 3 5.0% 4Z7HA
DFGout None 3 5.0% 4YZ9A
None None 2 3.3% 6HX1A
DFGin ABAminus 1 1.7% 4Z7HB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ERN1_HUMAN AF-O75460-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 561 - 840 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN AF-O75460-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 561 - 840 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3CA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 560 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3CB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3CC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3CD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 9GOWA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IOO Type1 562 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 9GOWC 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IOO Type1 562 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4Z7HB 2.9 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nioi 4L5 Type1 562 - 962 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 5HGIA 2.584 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6XDFB 2.54 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnio No_ligand No_ligand 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3BA 2.57 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 9GOWB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1IOO Type1 562 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 9GOWD 3.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii A1IOO Type1 562 - 964 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3EB 2.737 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaooi APEdist_nnoo SJV Type1.5_Back 563 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6XDFA 2.54 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi N94 Type1.5_Back 560 - 966 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 7BMKA 1.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi U4N Type1.5_Back 561 - 966 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 7BMKB 1.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_ioio U4N Type1.5_Back 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6URCA 2.2 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi QFV Type1.5_Back 560 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6URCB 2.2 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi QFV Type1.5_Back 560 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6XDDB 2.4 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii N97 Type1.5_Back 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4U6RA 2.5 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iioi 3E4 Type1.5_Back 561 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6XDBA 2.45 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi N8S Type1.5_Back 561 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3EA 2.737 Inactive DFGin‑BLAminus out-out none-none nonTYR APEdihe_aannn APEdist_nnnn SJV Type1.5_Front 562 - 962 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6XDDA 2.4 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiio APEdist_oiio N97 Type1.5_Front 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 8UVLA 2.43 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi XOE Type1.5_Front 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4YZDA 3.102 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4YZDB 3.102 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_niii ADP ATPlike 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4YZDC 3.102 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_niii ADP ATPlike 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 3P23A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 3P23B 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoi ADP ATPlike 564 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 3P23C 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_iioi ADP ATPlike 561 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 3P23D 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_nnoi ADP ATPlike 561 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 9N88A 2.6 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 9N88E 2.6 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W39A 1.736 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoo APEdist_nnnn SJG Type1 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W39B 1.736 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoo APEdist_nnnn SJG Type1 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3AA 2.606 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaooo APEdist_nnno SJM Type1 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3AB 2.606 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaooo APEdist_nnno SJM Type1 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4Z7GA 2.6 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnni No_ligand No_ligand 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4Z7GB 2.6 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnni No_ligand No_ligand 562 - 962 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4Z7HA 2.9 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi 4L5 Type1 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4YZ9A 2.463 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 4K7 Type3 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4YZ9B 2.463 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 4K7 Type3 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4YZ9C 2.463 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 4K7 Type3 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6HX1A 2.14 Inactive None‑None none-none out-out nonTYR APEdihe_aaooi APEdist_iioo GXK Type1 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6HV0A 2.73 Inactive None‑None none-none out-out nonTYR APEdihe_aaoii APEdist_iioo GUK Type1 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4YZCA 2.494 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 562 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 4YZCB 2.494 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 562 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_HUMAN 6W3KA 2.08 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii SJS Type1 562 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
ERN1_MOUSE 4PL4B 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL4C 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL4D 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 961 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL5B 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL5C 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL5D 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nioi ADP ATPlike 561 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL3A 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31J, ADP Allosteric, ATPlike 560 - 964 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL3B 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31J, ADP Allosteric, ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL4A 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31K, ADP Allosteric, ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL5A 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi 31L, ADP, PEU Allosteric, ATPlike, Allosteric 562 - 964 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus

OTHER_ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

Total number of chains: 10
Active chains: 0
Family: OTHER
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 10 100.0% 4PL5C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ERN1_MOUSE 4PL4B 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL4C 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL4D 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 961 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL5B 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL5C 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL5D 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nioi ADP ATPlike 561 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL3A 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31J, ADP Allosteric, ATPlike 560 - 964 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL3B 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31J, ADP Allosteric, ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL4A 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31K, ADP Allosteric, ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
ERN1_MOUSE 4PL5A 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi 31L, ADP, PEU Allosteric, ATPlike, Allosteric 562 - 964 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus