Ligand: ATP

Total number of chains: 173
Active chains: 68
Total number of genes: 31
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 112 64.7% 5LVOA
DFGin BLBplus 21 12.1% 3DKCA
DFGinter None 14 8.1% 9D5IA
DFGin None 12 6.9% 5I4NA
DFGin BLBtrans 6 3.5% 1HCKA
DFGin ABAminus 4 2.3% 7T4TA
None None 3 1.7% 4FG8B
DFGout None 1 0.6% 8FO9E
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC GRK5 GRK5_HUMAN 9CKRA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKSA 3.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 1H1WA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ATP ATPlike 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2BIYA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 72 - 359 0 None S241A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRCA 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RRVA 1.412 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5ACKA 1.24 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 73 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPB 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPC 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPD 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT2A 1.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5MRDA 1.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRFA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, P47 ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A06A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, A06 ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW0A 1.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, MJF ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW1A 1.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 21O ATPlike, Allosteric 66 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQKA 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, R1S ATPlike, Allosteric 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQVA 1.502 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, R2S ATPlike, Allosteric 71 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVOA 1.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 78W ATPlike, Allosteric 73 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT1A 1.85 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 31S ATPlike, Allosteric 76 - 359 0 SEP241 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4XX9A 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, RF4, RF4 ATPlike, Allosteric, Allosteric 71 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A07A 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, AZ7, AZ7 ATPlike, Allosteric, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PRKACA KAPCA_HUMAN 4WB8A 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB5A 1.641 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7E 3.55 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7G 3.55 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7B 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRA 3.661 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRC 3.661 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDCA 4.18 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDDA 6.3 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDEA 5.9 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 14 - 351 0 SEP11,SEP140,TPO198 L206R cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6B 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 9 - 351 0 SEP11,TPO198,SEP339 L206R cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKCI KPCI_HUMAN 3A8WA 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8WB 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 7T4TA 2.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PCG, ATP Allosteric, ATPlike 204 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4TB 2.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PCG, ATP Allosteric, ATPlike 204 - 671 0 TPO517 None cGMP-dependent protein kinase 1
CAMK AURKA AURKA_HUMAN 5DNRA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ATP ATPlike 126 - 390 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT3A 2.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ATP ATPlike 127 - 390 0 TPO287 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DRDA 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ATP ATPlike 127 - 390 0 None T287A Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL6A 3.0 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ATP ATPlike 128 - 388 0 None D274N Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DN3A 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo 5DN, ATP Allosteric, ATPlike 125 - 389 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1EA 2.798 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo T0X, ATP Allosteric, ATPlike 127 - 388 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT4A 2.86 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 5DN, ATP Allosteric, ATPlike 127 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DOSA 2.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 5DN, ATP Allosteric, ATPlike 127 - 390 0 None T287A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR2A 2.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 5E1, ATP Allosteric, ATPlike 128 - 390 0 None T287A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBJA 2.901 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo ATP, 9QK ATPlike, Allosteric 127 - 390 0 None None Aurora kinase A
CAMK CAMK1 KCC1A_HUMAN 4FG7A 2.7 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ATP ATPlike 9 - 277 0 None None Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9A 2.4 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn ATP ATPlike 10 - 314 0 None None Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9B 2.4 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaini APEdist_nnno ATP ATPlike 14 - 314 0 None None Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8A 2.2 Inactive None‑None out-none none-out nonTYR APEdihe_aanno APEdist_nnnn ATP ATPlike 10 - 299 0 None None Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8B 2.2 Inactive None‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnno ATP ATPlike 14 - 299 0 None None Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK2A KCC2A_HUMAN 7UIRA 3.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 274 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UIRB 3.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 273 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPB 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 273 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJTA 2.1 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 274 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK PHKG1 PHKG1_HUMAN 8Z5RC 3.52 Inactive DFGin‑BLAminus out-none out-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TC 3.74 Inactive DFGin‑BLAminus out-none out-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TG 3.74 Inactive DFGin‑BLAminus out-none out-out nonTYR APEdihe_aaiii APEdist_iooi ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TK 3.74 Inactive DFGin‑BLAminus out-none out-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TO 3.74 Inactive DFGin‑BLAminus out-none out-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK STK17B ST17B_HUMAN 7Q7DA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ATP ATPlike 25 - 297 0 None None Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7EA 2.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ATP ATPlike 25 - 297 0 None None Serine/threonine-protein kinase 17B
CK1 TTBK1 TTBK1_HUMAN 4BTJB 2.16 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 21 - 313 0 None None Tau-tubulin kinase 1
CMGC CDK2 CDK2_HUMAN 4EOOA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 297 0 TPO160 Q131E Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOOC 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 Q131E Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 297 0 TPO160 H84S,Q85M,Q131E Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMC 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 H84S,Q85M,Q131E Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINC 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FQ1B 3.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaoio APEdist_oioo ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 298 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTC 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 298 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 292 0 PTR15,TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 297 0 PTR15,TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3A 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3C 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZC 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHC 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIC 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 297 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQC 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJA 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 298 0 TPO160 H84S,Q85M,K89D Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJC 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 H84S,Q85M,K89D Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1HCKA 1.9 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8FP5A 1.7 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 2 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B38A 2.0 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B39A 2.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 1UA2A 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2B 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2C 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2D 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3BLQA 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 325 0 TPO186 None Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 5CU6A 1.36 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYDA 1.404 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, KD6 ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYRA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, KF6 ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AECA 1.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP, LW3 ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSPA 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, A9W ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSRA 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, AFK ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY2A 1.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, H4N, H4N ATPlike, Allosteric, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYOA 1.58 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, KEX, KEX ATPlike, Allosteric, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7B 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A8Q, ATP Allosteric, ATPlike 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDA 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A8Q, ATP Allosteric, ATPlike 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVFA 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54Z, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVFA 1.47 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 503, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVGA 1.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii E8K, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEKA 1.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LVL, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEMA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LVF, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHA 1.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54E, 54E, ATP Allosteric, Allosteric, ATPlike 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHB 1.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54E, 54E, ATP Allosteric, Allosteric, ATPlike 2 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7A 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A8Q, A8Q, ATP Allosteric, Allosteric, ATPlike 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDB 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A8Q, A8Q, ATP Allosteric, Allosteric, ATPlike 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS8A 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii J27, J27, J27, ATP Allosteric, Allosteric, Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTRA 1.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AU8, AU8, AU8, ATP Allosteric, Allosteric, Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
OTHER TTK TTK_HUMAN 3HMNA 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ATP ATPlike 516 - 794 0 None None Dual specificity protein kinase TTK
RGC NPR1 ANPRA_HUMAN 9BCOA 4.4 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaini APEdist_oooo ATP ATPlike 498 - 1053 0 None None Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCOB 4.4 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoni APEdist_oooo ATP ATPlike 501 - 1053 0 None None Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPA 4.1 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ATP ATPlike 505 - 842 0 None None Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPB 4.1 Pseudo DFGin‑BLBtrans out-none out-out nonTYR APEdihe_aaoao APEdist_oooo ATP ATPlike 503 - 841 0 None None Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSA 4.4 Pseudo DFGin‑None out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ATP ATPlike 503 - 1055 0 None None Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSB 4.4 Pseudo None‑None out-none out-out nonTYR APEdihe_aaoni APEdist_oooo ATP ATPlike 505 - 1055 0 None None Atrial natriuretic peptide receptor 1
STE MAP2K1 MP2K1_HUMAN 4AN3A 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onno ATP, 5Y0 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3OS3A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 3OS ATPlike, Type3 62 - 378 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DV3A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ATP, MEK ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3PP1A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, IZG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQBA 2.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, LUG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 1S9JA 2.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, BBM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DY7A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ATP, 1CX ATPlike, Type3 62 - 364 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3E8NA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo ATP, VRA ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHB 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHC 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 2P55A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo MRA, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V01A 2.705 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3V0, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V04A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo V04, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K2 MP2K2_HUMAN 1S9IA 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ATP, 5EA ATPlike, Type3 60 - 393 0 None None Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K2 MP2K2_HUMAN 1S9IB 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ATP, 5EA ATPlike, Type3 59 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 2
STE PAK1 PAK1_HUMAN 3Q53A 2.09 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 250 - 541 0 TPO423 K299R,L516I Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4XBRA 2.94 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 177 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3A7HA 1.96 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7HB 1.96 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 17 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 3GNIB 2.35 Pseudo DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaoai APEdist_iooo ATP ATPlike 60 - 431 0 None None STE20-related kinase adapter protein alpha
TKL ILK ILK_HUMAN 9D5IA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo ATP ATPlike 182 - 452 0 None R225A,C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA 2.0 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo ATP ATPlike 185 - 452 0 None C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA 1.8 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo ATP ATPlike 185 - 452 0 None C346S,C422S Scaffold protein ILK
TKL KSR2 KSR2_HUMAN 2Y4IB 3.46 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ATP ATPlike 653 - 931 0 None None Kinase suppressor of Ras 2
TKL LRRK2 LRRK2_HUMAN 8FO9A 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9C 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTA 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTB 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHWA 3.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 540 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI4A 3.1 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO2E 4.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8C 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8E 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9F 3.48 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI3A 3.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9E 3.48 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TYR EGFR EGFR_HUMAN 8PO4B 1.621 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao ATP ATPlike 700 - 1014 0 None V948R Epidermal growth factor receptor
TYR INSR INSR_HUMAN 3BU5A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ATP ATPlike 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
TYR JAK2-1 JAK2_HUMAN 5I4NA 1.54 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 809 0 None E596A,V617F,W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None V617F,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA 1.75 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A 2.2 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR MET MET_HUMAN 3DKCA 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ATP ATPlike 1051 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
TYR PTK2 FAK1_HUMAN 2IJMA 2.187 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao ATP ATPlike 414 - 688 0 None None Focal adhesion kinase 1

Ligand: ATP

Total number of chains: 237
Active chains: 97
Total number of genes: 49
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 155 65.4% 5LVOA
DFGin None 24 10.1% 5I4NA
DFGin BLBplus 23 9.7% 3DKCA
DFGinter None 14 5.9% 9D5IA
DFGin BLBtrans 8 3.4% 1HCKA
None None 5 2.1% 4FI1A
DFGin ABAminus 4 1.7% 7T4TA
DFGin BLBminus 3 1.3% 7Z9TBBB
DFGout None 1 0.4% 8FO9E
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL BRI1 BRI1_ARATH 5LPYA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 T872A Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDVA 1.97 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aanii APEdist_nnnn ATP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDVB 1.97 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aanii APEdist_nnnn ATP ATPlike 522 - 816 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA 2.15 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ATP ATPlike 1 - 862 0 None None Class III lanthionine synthetase LanKC Bacillus thuringiensis serovar andalousiensis
OTHER LANKC A0A6H0TJ16_BACTU 8SAMB 2.15 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn ATP ATPlike 1 - 862 0 None None Class III lanthionine synthetase LanKC Bacillus thuringiensis serovar andalousiensis
AGC GRK1 GRK1_BOVIN 3T8OA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 30 - 532 0 None L166K Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C4WA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 31 - 533 0 TPO8 None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C4WB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 5 - 533 0 TPO8 None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C4XA 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 30 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C4XB 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 31 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC PRKACA KAPCA_BOVIN 9DW9G 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 1Q24A 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 15 - 351 0 TPO198,SEP339 V124A,L174M cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
OTHER PAN3 PAN3_CHATD 4CYIA 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIB 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 213 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIC 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYID 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 214 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIE 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIF 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 213 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIG 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 212 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIH 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJA 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 630 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJB 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJC 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 210 - 632 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJD 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
AGC PRKACA KAPCA_CRIGR 6EMAA 1.88 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 6Y8CA 1.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC GRK5 GRK5_HUMAN 9CKRA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 9CKSA 3.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 1H1WA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ATP ATPlike 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 2BIYA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 72 - 359 0 None S241A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3HRCA 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4RRVA 1.412 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 5ACKA 1.24 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 73 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 5LVPA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 5LVPB 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 5LVPC 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 5LVPD 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4CT2A 1.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 5MRDA 1.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3HRFA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, P47 ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4A06A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, A06 ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4AW0A 1.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, MJF ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4AW1A 1.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 21O ATPlike, Allosteric 66 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4RQKA 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, R1S ATPlike, Allosteric 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4RQVA 1.502 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, R2S ATPlike, Allosteric 71 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 5LVOA 1.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 78W ATPlike, Allosteric 73 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4CT1A 1.85 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 31S ATPlike, Allosteric 76 - 359 0 SEP241 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4XX9A 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, RF4, RF4 ATPlike, Allosteric, Allosteric 71 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4A07A 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, AZ7, AZ7 ATPlike, Allosteric, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PRKACA KAPCA_HUMAN 4WB8A 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 4WB5A 1.641 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 6NO7E 3.55 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 6NO7G 3.55 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 4WB7A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 4WB7B 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 6BYRA 3.661 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 6BYRC 3.661 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 9EDCA 4.18 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 9EDDA 6.3 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 9EDEA 5.9 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 4WB6A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 14 - 351 0 SEP11,SEP140,TPO198 L206R cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 4WB6B 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 9 - 351 0 SEP11,TPO198,SEP339 L206R cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKCI KPCI_HUMAN 3A8WA 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
AGC PRKCI KPCI_HUMAN 3A8WB 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
AGC PRKG1 KGP1_HUMAN 7T4TA 2.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PCG, ATP Allosteric, ATPlike 204 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 7T4TB 2.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PCG, ATP Allosteric, ATPlike 204 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
CAMK AURKA AURKA_HUMAN 5DNRA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ATP ATPlike 126 - 390 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5DT3A 2.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ATP ATPlike 127 - 390 0 TPO287 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5DRDA 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ATP ATPlike 127 - 390 0 None T287A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 1OL6A 3.0 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ATP ATPlike 128 - 388 0 None D274N Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5DN3A 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo 5DN, ATP Allosteric, ATPlike 125 - 389 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1EA 2.798 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo T0X, ATP Allosteric, ATPlike 127 - 388 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5DT4A 2.86 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 5DN, ATP Allosteric, ATPlike 127 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5DOSA 2.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 5DN, ATP Allosteric, ATPlike 127 - 390 0 None T287A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5DR2A 2.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 5E1, ATP Allosteric, ATPlike 128 - 390 0 None T287A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OBJA 2.901 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo ATP, 9QK ATPlike, Allosteric 127 - 390 0 None None Aurora kinase A Homo sapiens
CAMK CAMK1 KCC1A_HUMAN 4FG7A 2.7 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ATP ATPlike 9 - 277 0 None None Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens
CAMK CAMK1 KCC1A_HUMAN 4FG9A 2.4 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn ATP ATPlike 10 - 314 0 None None Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens
CAMK CAMK1 KCC1A_HUMAN 4FG9B 2.4 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaini APEdist_nnno ATP ATPlike 14 - 314 0 None None Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens
CAMK CAMK1 KCC1A_HUMAN 4FG8A 2.2 Inactive None‑None out-none none-out nonTYR APEdihe_aanno APEdist_nnnn ATP ATPlike 10 - 299 0 None None Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens
CAMK CAMK1 KCC1A_HUMAN 4FG8B 2.2 Inactive None‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnno ATP ATPlike 14 - 299 0 None None Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 7UIRA 3.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 274 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 7UIRB 3.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 273 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 7UJPB 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 273 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 7UJTA 2.1 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 274 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK PHKG1 PHKG1_HUMAN 8Z5RC 3.52 Inactive DFGin‑BLAminus out-none out-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens
CAMK PHKG1 PHKG1_HUMAN 8Z5TC 3.74 Inactive DFGin‑BLAminus out-none out-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens
CAMK PHKG1 PHKG1_HUMAN 8Z5TG 3.74 Inactive DFGin‑BLAminus out-none out-out nonTYR APEdihe_aaiii APEdist_iooi ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens
CAMK PHKG1 PHKG1_HUMAN 8Z5TK 3.74 Inactive DFGin‑BLAminus out-none out-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens
CAMK PHKG1 PHKG1_HUMAN 8Z5TO 3.74 Inactive DFGin‑BLAminus out-none out-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 383 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens
CAMK STK17B ST17B_HUMAN 7Q7DA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ATP ATPlike 25 - 297 0 None None Serine/threonine-protein kinase 17B Homo sapiens
CAMK STK17B ST17B_HUMAN 7Q7EA 2.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ATP ATPlike 25 - 297 0 None None Serine/threonine-protein kinase 17B Homo sapiens
CK1 TTBK1 TTBK1_HUMAN 4BTJB 2.16 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 21 - 313 0 None None Tau-tubulin kinase 1 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EOOA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 297 0 TPO160 Q131E Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EOOC 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 Q131E Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EOMA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 297 0 TPO160 H84S,Q85M,Q131E Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EOMC 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 H84S,Q85M,Q131E Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1FINA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1FINC 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1FQ1B 3.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaoio APEdist_oioo ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1JSTA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 298 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1JSTC 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 298 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2CJMA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 292 0 PTR15,TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2CJMC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 297 0 PTR15,TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1GY3A 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1GY3C 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1QMZA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1QMZC 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2CCHA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2CCHC 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2CCIA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2CCIC 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EOQA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 297 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EOQC 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EOJA 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 298 0 TPO160 H84S,Q85M,K89D Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EOJC 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 296 0 TPO160 H84S,Q85M,K89D Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1HCKA 1.9 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 8FP5A 1.7 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 2 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1B38A 2.0 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1B39A 2.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK7 CDK7_HUMAN 1UA2A 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 1UA2B 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 1UA2C 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 1UA2D 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK9 CDK9_HUMAN 3BLQA 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 7 - 325 0 TPO186 None Cyclin-dependent kinase 9 Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CU6A 1.36 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7ZYDA 1.404 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, KD6 ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7ZYRA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, KF6 ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 8AECA 1.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP, LW3 ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OSPA 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, A9W ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OSRA 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, AFK ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7ZY2A 1.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, H4N, H4N ATPlike, Allosteric, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7ZYOA 1.58 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, KEX, KEX ATPlike, Allosteric, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OS7B 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A8Q, ATP Allosteric, ATPlike 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6GMDA 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A8Q, ATP Allosteric, ATPlike 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CVFA 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54Z, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6FVFA 1.47 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 503, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6FVGA 1.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii E8K, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 8AEKA 1.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LVL, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 8AEMA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LVF, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CSHA 1.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54E, 54E, ATP Allosteric, Allosteric, ATPlike 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CSHB 1.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54E, 54E, ATP Allosteric, Allosteric, ATPlike 2 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OS7A 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A8Q, A8Q, ATP Allosteric, Allosteric, ATPlike 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6GMDB 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A8Q, A8Q, ATP Allosteric, Allosteric, ATPlike 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OS8A 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii J27, J27, J27, ATP Allosteric, Allosteric, Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTRA 1.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AU8, AU8, AU8, ATP Allosteric, Allosteric, Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
OTHER TTK TTK_HUMAN 3HMNA 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ATP ATPlike 516 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
RGC NPR1 ANPRA_HUMAN 9BCOA 4.4 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaini APEdist_oooo ATP ATPlike 498 - 1053 0 None None Atrial natriuretic peptide receptor 1 Homo sapiens
RGC NPR1 ANPRA_HUMAN 9BCOB 4.4 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoni APEdist_oooo ATP ATPlike 501 - 1053 0 None None Atrial natriuretic peptide receptor 1 Homo sapiens
RGC NPR1 ANPRA_HUMAN 9BCPA 4.1 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ATP ATPlike 505 - 842 0 None None Atrial natriuretic peptide receptor 1 Homo sapiens
RGC NPR1 ANPRA_HUMAN 9BCPB 4.1 Pseudo DFGin‑BLBtrans out-none out-out nonTYR APEdihe_aaoao APEdist_oooo ATP ATPlike 503 - 841 0 None None Atrial natriuretic peptide receptor 1 Homo sapiens
RGC NPR1 ANPRA_HUMAN 9BCSA 4.4 Pseudo DFGin‑None out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ATP ATPlike 503 - 1055 0 None None Atrial natriuretic peptide receptor 1 Homo sapiens
RGC NPR1 ANPRA_HUMAN 9BCSB 4.4 Pseudo None‑None out-none out-out nonTYR APEdihe_aaoni APEdist_oooo ATP ATPlike 505 - 1055 0 None None Atrial natriuretic peptide receptor 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4AN3A 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onno ATP, 5Y0 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3OS3A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 3OS ATPlike, Type3 62 - 378 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3DV3A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ATP, MEK ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3PP1A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, IZG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQBA 2.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, LUG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 1S9JA 2.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, BBM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3DY7A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ATP, 1CX ATPlike, Type3 62 - 364 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3E8NA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo ATP, VRA ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3VVHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3VVHB 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3VVHC 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 2P55A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo MRA, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3V01A 2.705 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3V0, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3V04A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo V04, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K2 MP2K2_HUMAN 1S9IA 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ATP, 5EA ATPlike, Type3 60 - 393 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
STE MAP2K2 MP2K2_HUMAN 1S9IB 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ATP, 5EA ATPlike, Type3 59 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
STE PAK1 PAK1_HUMAN 3Q53A 2.09 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 250 - 541 0 TPO423 K299R,L516I Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK4 PAK4_HUMAN 4XBRA 2.94 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 177 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE STK24 STK24_HUMAN 3A7HA 1.96 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3A7HB 1.96 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 17 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STRADA STRAA_HUMAN 3GNIB 2.35 Pseudo DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaoai APEdist_iooo ATP ATPlike 60 - 431 0 None None STE20-related kinase adapter protein alpha Homo sapiens
TKL ILK ILK_HUMAN 9D5IA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo ATP ATPlike 182 - 452 0 None R225A,C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 3KMWA 2.0 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo ATP ATPlike 185 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 3REPA 1.8 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo ATP ATPlike 185 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL KSR2 KSR2_HUMAN 2Y4IB 3.46 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ATP ATPlike 653 - 931 0 None None Kinase suppressor of Ras 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO9A 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO9C 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LHTA 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LHTB 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LHWA 3.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 540 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LI4A 3.1 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO2E 4.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO8C 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO8E 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO9F 3.48 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LI3A 3.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO9E 3.48 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TYR EGFR EGFR_HUMAN 8PO4B 1.621 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao ATP ATPlike 700 - 1014 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR INSR INSR_HUMAN 3BU5A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ATP ATPlike 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
TYR JAK2-1 JAK2_HUMAN 5I4NA 1.54 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 809 0 None E596A,V617F,W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 4FVRA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None V617F,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 4FVQA 1.75 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8C08A 2.2 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8C08B 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR MET MET_HUMAN 3DKCA 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ATP ATPlike 1051 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
TYR PTK2 FAK1_HUMAN 2IJMA 2.187 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao ATP ATPlike 414 - 688 0 None None Focal adhesion kinase 1 Homo sapiens
TKL RIPK A0A811MC32_9POAL 8HOAA 1.676 Inactive DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaooo APEdist_nnno ATP, HX2 ATPlike, Allosteric 90 - 387 0 None None non-specific serine/threonine protein kinase Miscanthus lutarioriparius
AGC PRKACA KAPCA_MOUSE 1ATPE 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3FJQE 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH1A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH3A 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DINA 3.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 10 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4X6RA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 K8C cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3X2UA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3X2VA 1.77 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 18 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3X2WA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4XW5A 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3QAME 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 TPO198,SEP339 E209A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3QALE 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 TPO198,SEP339 R281A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1RDQE 1.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, ATP ATPlike, ATPlike 2 - 351 0 TPO198,SEP339 Y205A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YAAA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YAAB 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CMGC MAPK14 MK14_MOUSE 7Z9TBBB 2.6 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 87B, ATP Type3, Allosteric 4 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
STE STK39 STK39_MOUSE 5D9HA 3.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo ATP ATPlike 65 - 363 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5D9HB 3.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ATP ATPlike 65 - 364 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
TKL RIPK4 RIPK4_MOUSE 5WNIA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnoo ATP ATPlike 9 - 288 0 None D143N Receptor-interacting serine/threonine-protein kinase 4 Mus musculus
CAMK PHKG1 PHKG1_RABIT 2PHKA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 15 - 291 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Oryctolagus cuniculus
CAMK PHKG1 PHKG1_RABIT 1QL6A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 292 0 None E183S Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Oryctolagus cuniculus
CAMK PHKG1 PHKG1_RABIT 1PHKA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 292 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 2Y4IC 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP ATPlike 37 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
OTHER FLS2 FLS2_ORYSJ 8JUPA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_oooo ATP ATPlike 861 - 1176 0 None None LRR receptor-like serine/threonine-protein kinase FLS2 Oryza sativa
CMGC CK1 Q8IIR9_PLAF7 5XVUA 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 12 - 332 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
CMGC CK1 Q8IIR9_PLAF7 5XVUB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 12 - 332 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
CMGC CK1 Q8IIR9_PLAF7 5XVUC 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 12 - 332 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
CMGC MAPK1 MK01_RAT 4GT3A 1.68 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_oiii ATP ATPlike 9 - 356 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 1GOLA 2.8 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_oiii ATP ATPlike 2 - 358 0 None K52R Mitogen-activated protein kinase 1 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5RA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5RB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
CMGC CKA1 CSK21_YEAST 4FI1A 2.09 Inactive None‑None out-na in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 371 0 None None Casein kinase II subunit alpha Saccharomyces cerevisiae
CMGC CKA1 CSK21_YEAST 4MWHA 2.09 Inactive None‑None out-na in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 371 0 None None Casein kinase II subunit alpha Saccharomyces cerevisiae
CMGC SKY1 SKY1_YEAST 1Q97A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 144 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae
OTHER GCN2-2 GCN2_YEAST 1ZYDA 2.75 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo ATP ATPlike 594 - 996 0 None None eIF-2-alpha kinase GCN2 Saccharomyces cerevisiae
OTHER GCN2-2 GCN2_YEAST 1ZYDB 2.75 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaoii APEdist_nnoo ATP ATPlike 594 - 983 0 None None eIF-2-alpha kinase GCN2 Saccharomyces cerevisiae
CK1 CKI1 CKI1_SCHPO 1CSNA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 6 - 298 0 None None Casein kinase I homolog 1 Schizosaccharomyces pombe

Ligand: ATP

Total number of chains: 64
Active chains: 29
Total number of genes: 21
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 43 67.2% 1RDQE
DFGin None 12 18.8% 4CYIA
DFGin BLBminus 3 4.7% 7Z9TBBB
DFGin BLBplus 2 3.1% 8HOAA
DFGin BLBtrans 2 3.1% 5D9HB
None None 2 3.1% 4FI1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL BRI1 BRI1_ARATH 5LPYA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 T872A Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDVA 1.97 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aanii APEdist_nnnn ATP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDVB 1.97 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aanii APEdist_nnnn ATP ATPlike 522 - 816 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA 2.15 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ATP ATPlike 1 - 862 0 None None Class III lanthionine synthetase LanKC Bacillus thuringiensis serovar andalousiensis
OTHER LANKC A0A6H0TJ16_BACTU 8SAMB 2.15 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn ATP ATPlike 1 - 862 0 None None Class III lanthionine synthetase LanKC Bacillus thuringiensis serovar andalousiensis
AGC GRK1 GRK1_BOVIN 3T8OA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 30 - 532 0 None L166K Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C4WA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 31 - 533 0 TPO8 None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C4WB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 5 - 533 0 TPO8 None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C4XA 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 30 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C4XB 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 31 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC PRKACA KAPCA_BOVIN 9DW9G 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 1Q24A 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 15 - 351 0 TPO198,SEP339 V124A,L174M cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
OTHER PAN3 PAN3_CHATD 4CYIA 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIB 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 213 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIC 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYID 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 214 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIE 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIF 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 213 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIG 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 212 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYIH 2.42 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 215 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJA 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 630 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJB 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJC 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 210 - 632 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
OTHER PAN3 PAN3_CHATD 4CYJD 2.59 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ATP ATPlike 207 - 631 0 None None PAN2-PAN3 deadenylation complex subunit PAN3 Chaetomium thermophilum
AGC PRKACA KAPCA_CRIGR 6EMAA 1.88 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 6Y8CA 1.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
TKL RIPK A0A811MC32_9POAL 8HOAA 1.676 Inactive DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaooo APEdist_nnno ATP, HX2 ATPlike, Allosteric 90 - 387 0 None None non-specific serine/threonine protein kinase Miscanthus lutarioriparius
AGC PRKACA KAPCA_MOUSE 1ATPE 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3FJQE 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH1A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH3A 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DINA 3.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 10 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4X6RA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 K8C cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3X2UA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3X2VA 1.77 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 18 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3X2WA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4XW5A 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3QAME 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 TPO198,SEP339 E209A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3QALE 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 2 - 351 0 TPO198,SEP339 R281A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1RDQE 1.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, ATP ATPlike, ATPlike 2 - 351 0 TPO198,SEP339 Y205A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YAAA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YAAB 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CMGC MAPK14 MK14_MOUSE 7Z9TBBB 2.6 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 87B, ATP Type3, Allosteric 4 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
STE STK39 STK39_MOUSE 5D9HA 3.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo ATP ATPlike 65 - 363 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5D9HB 3.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ATP ATPlike 65 - 364 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
TKL RIPK4 RIPK4_MOUSE 5WNIA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnoo ATP ATPlike 9 - 288 0 None D143N Receptor-interacting serine/threonine-protein kinase 4 Mus musculus
CAMK PHKG1 PHKG1_RABIT 2PHKA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 15 - 291 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Oryctolagus cuniculus
CAMK PHKG1 PHKG1_RABIT 1QL6A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 292 0 None E183S Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Oryctolagus cuniculus
CAMK PHKG1 PHKG1_RABIT 1PHKA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 16 - 292 0 None None Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 2Y4IC 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP ATPlike 37 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
OTHER FLS2 FLS2_ORYSJ 8JUPA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_oooo ATP ATPlike 861 - 1176 0 None None LRR receptor-like serine/threonine-protein kinase FLS2 Oryza sativa
CMGC CK1 Q8IIR9_PLAF7 5XVUA 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 12 - 332 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
CMGC CK1 Q8IIR9_PLAF7 5XVUB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 12 - 332 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
CMGC CK1 Q8IIR9_PLAF7 5XVUC 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 12 - 332 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
CMGC MAPK1 MK01_RAT 4GT3A 1.68 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_oiii ATP ATPlike 9 - 356 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 1GOLA 2.8 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_oiii ATP ATPlike 2 - 358 0 None K52R Mitogen-activated protein kinase 1 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5RA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5RB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
CMGC CKA1 CSK21_YEAST 4FI1A 2.09 Inactive None‑None out-na in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 371 0 None None Casein kinase II subunit alpha Saccharomyces cerevisiae
CMGC CKA1 CSK21_YEAST 4MWHA 2.09 Inactive None‑None out-na in-out nonTYR APEdihe_aaioi APEdist_iiii ATP ATPlike 1 - 371 0 None None Casein kinase II subunit alpha Saccharomyces cerevisiae
CMGC SKY1 SKY1_YEAST 1Q97A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 144 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae
OTHER GCN2-2 GCN2_YEAST 1ZYDA 2.75 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo ATP ATPlike 594 - 996 0 None None eIF-2-alpha kinase GCN2 Saccharomyces cerevisiae
OTHER GCN2-2 GCN2_YEAST 1ZYDB 2.75 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaoii APEdist_nnoo ATP ATPlike 594 - 983 0 None None eIF-2-alpha kinase GCN2 Saccharomyces cerevisiae
CK1 CKI1 CKI1_SCHPO 1CSNA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 6 - 298 0 None None Casein kinase I homolog 1 Schizosaccharomyces pombe