NEK_NEK2 (Serine/threonine-protein kinase Nek2)

Total number of chains: 31
Active chains: 2
Uniprot: NEK2_HUMAN
Kinase Domain Residues: 8 - 271
Spatial label Dihedral label Number of Chains Percent Representative
None None 15 48.4% 2W5AA
DFGout None 6 19.4% 2XNPA
DFGin None 5 16.1% 5M51A
DFGin BLAminus 2 6.5% AF-P51955-K1A
DFGinter None 2 6.5% 2W5BA
DFGin BLBminus 1 3.2% 5M53A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P51955-K1A -1.0 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 279 0 None None Serine/threonine-protein kinase Nek2
AF-P51955-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 279 0 None None Serine/threonine-protein kinase Nek2
5M53A 1.9 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo 7GJ Type1 7 - 271 0 None None Serine/threonine-protein kinase Nek2
2XKDA 1.96 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnnn T3M Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XKEA 2.203 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanio APEdist_nnnn WI2 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XKFA 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno BX1 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
5M51A 1.899 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno NU6 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
5M57A 2.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno 4SP Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2W5BA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo AGS ATPlike 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2
2W5HA 2.33 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaiio APEdist_iooo No_ligand No_ligand 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2
2XK3A 2.2 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno XK3 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XK4A 2.1 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo OL2 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XK8A 2.001 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 5R1 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XNPA 1.98 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo WCX Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
4AFEA 2.597 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnoo GGY Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
4A4XA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnoo JUP Type1 3 - 271 0 None T170E,S171D,T175E Serine/threonine-protein kinase Nek2
2W5AA 1.55 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ADP ATPlike 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2WQOA 2.167 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnnn VGK Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XK6A 2.2 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno EQH Type1 4 - 271 0 None None Serine/threonine-protein kinase Nek2
2XK7A 1.992 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 30E Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XKCA 2.5 Inactive None‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnnn 4VQ Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XNMA 1.85 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo WGZ Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XNNA 2.5 Inactive None‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno 430 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
2XNOA 1.98 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno ED8 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
5M55A 2.4 Inactive None‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn 7GG Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
6SGDA 2.0 Inactive None‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnnn LD5 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
6SGHA 3.0 Inactive None‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LCW Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
6SGIA 2.3 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno LCB Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
6SGKA 2.0 Inactive None‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnnn LCQ Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
6SK9A 2.0 Inactive None‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnnn F9N Type1 4 - 271 0 None None Serine/threonine-protein kinase Nek2
2JAVA 2.2 Inactive None‑None out-out none-out nonTYR APEdihe_aaooo APEdist_nnnn 5Z5 Type1 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2

NEK_NEK2 (Serine/threonine-protein kinase Nek2)

Total number of chains: 31
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
None None 15 48.4% 2W5AA
DFGout None 6 19.4% 2XNPA
DFGin None 5 16.1% 5M51A
DFGin BLAminus 2 6.5% AF-P51955-K1A
DFGinter None 2 6.5% 2W5BA
DFGin BLBminus 1 3.2% 5M53A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
NEK2_HUMAN AF-P51955-K1A -1.0 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 279 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN AF-P51955-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 279 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 5M53A 1.9 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo 7GJ Type1 7 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XKDA 1.96 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnnn T3M Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XKEA 2.203 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanio APEdist_nnnn WI2 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XKFA 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno BX1 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 5M51A 1.899 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno NU6 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 5M57A 2.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno 4SP Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2W5BA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo AGS ATPlike 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2W5HA 2.33 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaiio APEdist_iooo No_ligand No_ligand 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XK3A 2.2 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno XK3 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XK4A 2.1 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo OL2 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XK8A 2.001 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 5R1 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XNPA 1.98 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo WCX Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 4AFEA 2.597 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnoo GGY Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 4A4XA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnoo JUP Type1 3 - 271 0 None T170E,S171D,T175E Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2W5AA 1.55 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ADP ATPlike 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2WQOA 2.167 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnnn VGK Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XK6A 2.2 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno EQH Type1 4 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XK7A 1.992 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 30E Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XKCA 2.5 Inactive None‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnnn 4VQ Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XNMA 1.85 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo WGZ Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XNNA 2.5 Inactive None‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnno 430 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2XNOA 1.98 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno ED8 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 5M55A 2.4 Inactive None‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn 7GG Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 6SGDA 2.0 Inactive None‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnnn LD5 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 6SGHA 3.0 Inactive None‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LCW Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 6SGIA 2.3 Inactive None‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno LCB Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 6SGKA 2.0 Inactive None‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnnn LCQ Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 6SK9A 2.0 Inactive None‑None out-none none-out nonTYR APEdihe_aaioo APEdist_nnnn F9N Type1 4 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK2_HUMAN 2JAVA 2.2 Inactive None‑None out-out none-out nonTYR APEdihe_aaooo APEdist_nnnn 5Z5 Type1 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2 Homo sapiens

NEK_NEK2 (Serine/threonine-protein kinase Nek2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism