STE_MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

Total number of chains: 104
Active chains: 3
Uniprot: M4K1_HUMAN
Kinase Domain Residues: 17 - 274
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 57 54.8% AF-Q92918-K1A
DFGin None 16 15.4% 9H8FA
DFGout BBAminus 13 12.5% 7M0KA
DFGout None 8 7.7% 9N7RA
DFGinter None 4 3.8% 9BI8A
None None 4 3.8% 6CQEB
DFGin ABAminus 2 1.9% 6NFYB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q92918-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 282 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
AF-Q92918-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 282 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
6NFZB 2.966 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 5 - 292 0 TPO165,SEP171 None Mitogen-activated protein kinase kinase kinase kinase 1
6NFYA 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi B49 Type1 10 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
6NFYB 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioi B49 Type1 10 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
6CQDA 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 2 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
6CQDB 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7KACB 1.85 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo W9D Type1 7 - 294 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1
7M0MA 1.93 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo YK1 Type1 2 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0MB 1.93 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo YK1 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7R9NA 1.5 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7R9NB 1.5 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7R9PA 2.27 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2WI Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7R9PB 2.27 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2WI Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7R9TA 2.0 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2TR Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7R9TB 2.0 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2TR Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9CZTA 1.69 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1E Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9CZTB 1.69 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1E Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9CZUA 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9CZUB 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nooo A1A1D Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9CZUC 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 2 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9CZUD 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 8 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9CZWA 1.59 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo A1A1C Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9CZWB 1.59 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1C Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9CZXA 1.464 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1B Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9D00A 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9D00B 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9D00C 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9D00D 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9BIKB 2.25 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APO Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9BJ1A 2.18 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APR Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9NACA 1.45 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWM Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9NACB 1.45 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1BWM Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9NBSA 1.8 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BW4 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9NBSB 1.8 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BW4 Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9NC2A 1.5 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 3 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9NC2B 1.5 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FH4A 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FH4B 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FH4C 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FH4D 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno XXF Type1 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FJZA 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 3 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FJZB 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FJZC 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FJZD 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FJZE 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo Y3I Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FJZF 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 9 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FKOA 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3O Type1 4 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FKOB 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FKOC 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FKOD 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FKOE 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo Y3O Type1 9 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
7L24A 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aannn APEdist_onnn XHV Type1 7 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7L24B 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo XHV Type1 7 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7L24C 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanii APEdist_ooon XHV Type1 8 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7L24D 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XHV Type1 8 - 292 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
9CZXB 1.464 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1B, A1A1B Type1, Allosteric 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9BJ1B 2.18 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1APQ Type1.5_Back 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7KACA 1.85 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno W9D Type1 7 - 304 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1
9H8DA 1.641 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITC Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9H8EA 1.631 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITA Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9H8FA 1.393 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITB Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9QT6A 1.76 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo A1JAF Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
6NG0A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo B49 Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
6CQFA 2.246 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo F97 Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7R9LA 2.332 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo 2YE Type1 7 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7L26A 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7L26B 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7L26C 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7L26D 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7L25A 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 7 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7L25B 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 6 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
7SIUA 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oioo 9ID Type1.5_Back 5 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7SIUB 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9ID Type1.5_Back 16 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9BI8A 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9BI8B 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9N9XA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9N9XB 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0KA 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0KB 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 8 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0KC 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 8 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0KD 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0LA 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0LB 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 7 - 291 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0LC 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
7M0LD 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
8XN7A 2.65 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo A1LVT Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8XN7B 2.65 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo A1LVT Type1 6 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
6NG0B 2.05 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo B49 Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
9BIKA 2.25 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_oooo A1APO Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9N7RB 2.13 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWC Type1 8 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
9N7RA 2.13 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo A1BWC, A1BWC, A1BWC, A1BWC Allosteric, Allosteric, Type1, Type3 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
8PAUA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
8PAUB 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
8PASA 2.7 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 8 - 295 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
8PASB 2.7 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
8CDWA 1.941 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
8CIJA 2.821 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni USF Type1 14 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
8PARA 2.0 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XON Type1 7 - 294 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
8FKOF 2.104 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 57 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
6CQEA 1.886 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 4 - 293 0 None S171A Mitogen-activated protein kinase kinase kinase kinase 1
6CQEB 1.886 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 5 - 293 0 None S171A Mitogen-activated protein kinase kinase kinase kinase 1
8CDWB 1.941 Inactive None‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 9 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
6NFZA 2.966 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 7 - 292 0 TPO165,SEP171 None Mitogen-activated protein kinase kinase kinase kinase 1

STE_MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

Total number of chains: 104
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 57 54.8% AF-Q92918-K1A
DFGin None 16 15.4% 9H8FA
DFGout BBAminus 13 12.5% 7M0KA
DFGout None 8 7.7% 9N7RA
DFGinter None 4 3.8% 9BI8A
None None 4 3.8% 6CQEB
DFGin ABAminus 2 1.9% 6NFYB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
M4K1_HUMAN AF-Q92918-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 282 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN AF-Q92918-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 282 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6NFZB 2.966 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 5 - 292 0 TPO165,SEP171 None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6NFYA 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi B49 Type1 10 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6NFYB 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioi B49 Type1 10 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6CQDA 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 2 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6CQDB 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7KACB 1.85 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo W9D Type1 7 - 294 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0MA 1.93 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo YK1 Type1 2 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0MB 1.93 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo YK1 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7R9NA 1.5 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7R9NB 1.5 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7R9PA 2.27 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2WI Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7R9PB 2.27 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2WI Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7R9TA 2.0 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2TR Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7R9TB 2.0 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2TR Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZTA 1.69 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1E Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZTB 1.69 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1E Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZUA 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZUB 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nooo A1A1D Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZUC 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 2 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZUD 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 8 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZWA 1.59 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo A1A1C Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZWB 1.59 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1C Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZXA 1.464 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1B Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9D00A 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9D00B 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9D00C 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9D00D 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9BIKB 2.25 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APO Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9BJ1A 2.18 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APR Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9NACA 1.45 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWM Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9NACB 1.45 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1BWM Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9NBSA 1.8 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BW4 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9NBSB 1.8 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BW4 Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9NC2A 1.5 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 3 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9NC2B 1.5 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FH4A 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FH4B 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FH4C 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FH4D 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno XXF Type1 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FJZA 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 3 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FJZB 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FJZC 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FJZD 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FJZE 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo Y3I Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FJZF 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 9 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FKOA 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3O Type1 4 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FKOB 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FKOC 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FKOD 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FKOE 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo Y3O Type1 9 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L24A 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aannn APEdist_onnn XHV Type1 7 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L24B 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo XHV Type1 7 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L24C 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanii APEdist_ooon XHV Type1 8 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L24D 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XHV Type1 8 - 292 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9CZXB 1.464 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1B, A1A1B Type1, Allosteric 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9BJ1B 2.18 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1APQ Type1.5_Back 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7KACA 1.85 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno W9D Type1 7 - 304 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9H8DA 1.641 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITC Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9H8EA 1.631 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITA Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9H8FA 1.393 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITB Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9QT6A 1.76 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo A1JAF Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6NG0A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo B49 Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6CQFA 2.246 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo F97 Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7R9LA 2.332 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo 2YE Type1 7 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L26A 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L26B 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L26C 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L26D 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L25A 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 7 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7L25B 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 6 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7SIUA 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oioo 9ID Type1.5_Back 5 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7SIUB 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9ID Type1.5_Back 16 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9BI8A 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9BI8B 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9N9XA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9N9XB 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0KA 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0KB 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 8 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0KC 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 8 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0KD 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0LA 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0LB 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 7 - 291 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0LC 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 7M0LD 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8XN7A 2.65 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo A1LVT Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8XN7B 2.65 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo A1LVT Type1 6 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6NG0B 2.05 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo B49 Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9BIKA 2.25 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_oooo A1APO Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9N7RB 2.13 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWC Type1 8 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 9N7RA 2.13 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo A1BWC, A1BWC, A1BWC, A1BWC Allosteric, Allosteric, Type1, Type3 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8PAUA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8PAUB 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8PASA 2.7 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 8 - 295 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8PASB 2.7 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8CDWA 1.941 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8CIJA 2.821 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni USF Type1 14 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8PARA 2.0 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XON Type1 7 - 294 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8FKOF 2.104 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 57 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6CQEA 1.886 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 4 - 293 0 None S171A Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6CQEB 1.886 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 5 - 293 0 None S171A Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 8CDWB 1.941 Inactive None‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 9 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
M4K1_HUMAN 6NFZA 2.966 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 7 - 292 0 TPO165,SEP171 None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens

STE_MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism