Ligand: 52P (Neflamapimod)

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 3 100.0% 3FC1X
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC MAPK14 MK14_HUMAN 3ZSIA 2.4 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 52P Type1 6 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FC1X 2.4 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 52P Type1 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP5A 2.3 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoni APEdist_nnno 52P, I46, I46 Type1, Allosteric, Allosteric 6 - 352 0 None None Mitogen-activated protein kinase 14

Ligand: 52P (Neflamapimod)

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 3 100.0% 3FC1X
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK14 MK14_HUMAN 3ZSIA 2.4 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 52P Type1 6 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3FC1X 2.4 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 52P Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HP5A 2.3 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoni APEdist_nnno 52P, I46, I46 Type1, Allosteric, Allosteric 6 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens

Ligand: 52P (Neflamapimod)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism