All / All / Allosteric

Total number of chains: 98
Active chains: 36
Total number of genes: 18
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 55 56.1% 5OTOA
None None 12 12.2% 6Q3FA
DFGout BBAminus 9 9.2% 6HHJA
DFGin ABAminus 4 4.1% 7T4UA
DFGin BLBminus 4 4.1% 8YD9A
DFGin BLBplus 4 4.1% 8JN8A
DFGin None 4 4.1% 8X3MA
DFGout None 3 3.1% 6YZ4A
DFGin BLBtrans 2 2.0% 5OSJA
DFGin BLAplus 1 1.0% 9LBGB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC AKT1 AKT1_HUMAN 8UVYA 2.11 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_iiio XOO Allosteric 3 - 439 0 None E17K RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 8UW2A 2.2 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaioi APEdist_oooo XOO Allosteric 4 - 437 0 None None RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 8UW9A 1.9 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_iiio XQ2 Allosteric 3 - 428 0 None None RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 8UW7A 1.972 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno XOO Allosteric 3 - 439 0 None None RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3O96A 2.7 Inactive DFGout‑BBAminus none-none out-none nonTYR APEdihe_aannn APEdist_nnnn IQO Allosteric 2 - 429 0 None None RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHHA 2.7 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaooi APEdist_nnno G4Q Allosteric 2 - 439 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHJA 2.3 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo G4H Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6S9WA 2.3 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo L1Z Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 5KCVA 2.7 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn 6S1 Allosteric 6 - 438 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHFA 2.9 Inactive None‑None none-none out-out nonTYR APEdihe_aanoi APEdist_nnnn G4K Allosteric 3 - 439 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHGA 2.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo G4T Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHIA 2.7 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo G4N Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6S9XA 2.6 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo L1W Allosteric 3 - 443 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 7NH4A 2.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo UCE Allosteric 4 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 7NH5A 1.9 Inactive None‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo UC8 Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 9C1WA 2.0 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XOO Allosteric 3 - 440 0 None P115A,G116A RAC-beta serine/threonine-protein kinase
AGC PDPK1 PDPK1_HUMAN 3ORXA 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXB 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 77 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXC 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXD 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 76 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXE 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 1F8 Allosteric 76 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXF 2.204 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXG 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXH 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PRKACA KAPCA_HUMAN 5IZJA 1.85 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii 6J9 Allosteric 15 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5IZJB 1.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii 6J9 Allosteric 15 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5J5XA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6J9 Allosteric 10 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKG1 KGP1_HUMAN 7T4UA 1.99 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX6 Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4UB 1.99 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX6 Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4WA 2.23 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZJ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4WB 2.23 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZJ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4VA 2.28 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iiio EXZ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4VB 2.28 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EXZ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
CAMK CHEK1 CHK1_HUMAN 3JVRA 1.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGX Allosteric 2 - 272 0 None None Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3JVSA 1.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGY Allosteric 2 - 272 0 None None Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3F9NA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 38M Allosteric 7 - 270 0 None None Serine/threonine-protein kinase Chk1
CMGC CDK2 CDK2_HUMAN 8VQ3A 1.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioi A1AC4 Allosteric 1 - 297 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8VQ4A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnni A1AC5 Allosteric 1 - 297 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESOA 2.396 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3A Allosteric 1 - 298 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5OO0A 1.6 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9YZ Allosteric 2 - 296 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5OSJA 1.83 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AAK Allosteric 2 - 296 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q3FA 1.18 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo HEW Allosteric 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q49A 1.0 Inactive None‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo HGQ Allosteric 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CSNK2A1 CSK21_HUMAN 5CT0A 2.008 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54P Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CT0B 2.008 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54P Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CTPA 2.033 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54R Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CTPB 2.033 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54R Allosteric 3 - 329 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MMFA 1.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JMB Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MMRB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H83 Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MO6A 1.825 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KXZ Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MO7A 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YRA Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MODA 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 86L Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OT5A 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AWK Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OT5B 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AWK Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OT6A 1.94 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AJK Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTDA 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AOW Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTDB 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AOW Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTHA 1.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQ8 Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTHB 1.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQ8 Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTLA 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQT Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTLB 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQT Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTOA 1.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQW Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTOB 1.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQW Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OUEB 2.01 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AVZ Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OUMA 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AVK Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OUUA 1.81 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AWN Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OUUB 1.81 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AWN Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6EIIA 1.935 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B5W Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6EIIB 1.935 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B5W Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY5A 1.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 1NP Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 9HL0A 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1IVS Allosteric 2 - 332 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GIHA 1.96 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZN Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSUA 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AFW Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC GSK3B GSK3B_HUMAN 9X2VA 1.39 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoii APEdist_iiii PG6 Allosteric 35 - 383 0 None None Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 7W5OB 2.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 6GI Allosteric 12 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK14 MK14_HUMAN 5N68A 1.85 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 8OK Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 8YD9A 1.66 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 6GI Allosteric 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3NEWA 2.51 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 3NE Allosteric 5 - 352 0 None C162S Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E6AA 2.09 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 0O9 Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E6CA 2.39 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 0O8 Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5N67A 1.9 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8ON Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 8X3MA 1.85 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo B8Z Allosteric 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5N64A 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8OH Allosteric 5 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E8AA 2.7 Inactive None‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 0OA Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5N63A 2.4 Inactive None‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8OW Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5O8UA 2.0 Inactive None‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 9O5 Allosteric 5 - 352 0 None S252C Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5O8VA 2.0 Inactive None‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 9O2 Allosteric 5 - 354 0 None S251C Mitogen-activated protein kinase 14
CMGC MAPK8 MK08_HUMAN 3O2MA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 46A Allosteric 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 3O2MB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 46A Allosteric 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
OTHER MLKL MLKL_HUMAN 4MWIA 1.7 Pseudo DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo PXN Allosteric 193 - 470 0 None None Mixed lineage kinase domain-like protein
STE MAP2K7 MP2K7_HUMAN 6YZ4A 1.7 Inactive DFGout‑None na-na out-out nonTYR APEdihe_aaoai APEdist_nnno 1E8 Allosteric 101 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE PAK2 PAK2_HUMAN 9LBGB 2.89 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aanoo APEdist_nnnn MLT Allosteric 91 - 522 0 None K278R Serine/threonine-protein kinase PAK 2
TYR ABL1 ABL1_HUMAN 2HZ4A 2.8 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4ST Allosteric 234 - 500 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HZ4C 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4ST Allosteric 234 - 500 0 None None Tyrosine-protein kinase ABL1
TYR MET MET_HUMAN 3Q6UA 1.6 Inactive DFGin‑BLBminus in-out none-none TYR APEdihe_nniai APEdist_aaai AME Allosteric 1048 - 1348 0 None None Hepatocyte growth factor receptor
TYR SRC SRC_HUMAN 9IRLA 2.031 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao A1L20 Allosteric 86 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 8JN8A 1.902 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao JA6 Allosteric 86 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 8JN9A 2.724 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao UJ0 Allosteric 86 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src

All / All / Allosteric

Total number of chains: 155
Active chains: 47
Total number of genes: 27
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 73 47.1% 5N1GA
DFGin BLBminus 32 20.6% 5R9VA
None None 12 7.7% 6Q3FA
DFGin ABAminus 9 5.8% 7T4UA
DFGout BBAminus 9 5.8% 6HHJA
DFGin None 8 5.2% 8X3MA
DFGout None 5 3.2% 8CAVA
DFGin BLBplus 4 2.6% 8JN8A
DFGin BLBtrans 2 1.3% 5OSJA
DFGin BLAplus 1 0.6% 9LBGB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CKA1 CSK21_ARATH 9TFYA 5.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii IHP Allosteric 78 - 409 0 None None Casein kinase II subunit alpha-1 Arabidopsis thaliana
CMGC CKA1 CSK21_ARATH 9TFYB 5.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii IHP Allosteric 78 - 409 0 None None Casein kinase II subunit alpha-1 Arabidopsis thaliana
OTHER BIR2 BIR2_ARATH 4L68A 2.0 Pseudo DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiai APEdist_nioi PDO Allosteric 272 - 600 0 None None Inactive LRR receptor-like serine/threonine-protein kinase BIR2 Arabidopsis thaliana
CAMK TWITCHIN UNC22_CAEEL 3UTOB 2.4 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooo P33 Allosteric 6112 - 6675 0 None None Twitchin Caenorhabditis elegans
AGC PRKACA KAPCA_CRIGR 5N3NA 1.224 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 152 Allosteric 12 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N1GA 1.14 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 8G5 Allosteric 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N1NA 1.405 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8G8 Allosteric 1 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N3IA 1.14 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BJQ Allosteric 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N3KA 1.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii GGB Allosteric 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N3RA 1.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CDT Allosteric 13 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 6Z08A 1.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NPO Allosteric 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9RE2A 1.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JE1 Allosteric 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9REHA 1.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1JEO Allosteric 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9REMA 1.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JEL Allosteric 12 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9RESA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JEG Allosteric 12 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9RETA 1.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JEF Allosteric 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC AKT1 AKT1_HUMAN 8UVYA 2.11 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_iiio XOO Allosteric 3 - 439 0 None E17K RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 8UW2A 2.2 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaioi APEdist_oooo XOO Allosteric 4 - 437 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 8UW9A 1.9 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_iiio XQ2 Allosteric 3 - 428 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 8UW7A 1.972 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno XOO Allosteric 3 - 439 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 3O96A 2.7 Inactive DFGout‑BBAminus none-none out-none nonTYR APEdihe_aannn APEdist_nnnn IQO Allosteric 2 - 429 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 6HHHA 2.7 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaooi APEdist_nnno G4Q Allosteric 2 - 439 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 6HHJA 2.3 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo G4H Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 6S9WA 2.3 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo L1Z Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 5KCVA 2.7 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn 6S1 Allosteric 6 - 438 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 6HHFA 2.9 Inactive None‑None none-none out-out nonTYR APEdihe_aanoi APEdist_nnnn G4K Allosteric 3 - 439 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 6HHGA 2.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo G4T Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 6HHIA 2.7 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo G4N Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 6S9XA 2.6 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo L1W Allosteric 3 - 443 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 7NH4A 2.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo UCE Allosteric 4 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 7NH5A 1.9 Inactive None‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo UC8 Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT2 AKT2_HUMAN 9C1WA 2.0 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XOO Allosteric 3 - 440 0 None P115A,G116A RAC-beta serine/threonine-protein kinase Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORXA 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORXB 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 77 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORXC 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORXD 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 76 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORXE 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 1F8 Allosteric 76 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORXF 2.204 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORXG 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORXH 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PRKACA KAPCA_HUMAN 5IZJA 1.85 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii 6J9 Allosteric 15 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 5IZJB 1.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii 6J9 Allosteric 15 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKACA KAPCA_HUMAN 5J5XA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6J9 Allosteric 10 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
AGC PRKG1 KGP1_HUMAN 7T4UA 1.99 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX6 Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 7T4UB 1.99 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX6 Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 7T4WA 2.23 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZJ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 7T4WB 2.23 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZJ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 7T4VA 2.28 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iiio EXZ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 7T4VB 2.28 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EXZ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 3JVRA 1.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGX Allosteric 2 - 272 0 None None Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 3JVSA 1.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGY Allosteric 2 - 272 0 None None Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 3F9NA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 38M Allosteric 7 - 270 0 None None Serine/threonine-protein kinase Chk1 Homo sapiens
CMGC CDK2 CDK2_HUMAN 8VQ3A 1.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioi A1AC4 Allosteric 1 - 297 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 8VQ4A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnni A1AC5 Allosteric 1 - 297 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 9ESOA 2.396 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3A Allosteric 1 - 298 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 5OO0A 1.6 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9YZ Allosteric 2 - 296 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 5OSJA 1.83 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AAK Allosteric 2 - 296 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 6Q3FA 1.18 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo HEW Allosteric 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 6Q49A 1.0 Inactive None‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo HGQ Allosteric 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CT0A 2.008 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54P Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CT0B 2.008 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54P Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CTPA 2.033 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54R Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CTPB 2.033 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 54R Allosteric 3 - 329 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MMFA 1.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JMB Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MMRB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H83 Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MO6A 1.825 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KXZ Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MO7A 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YRA Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MODA 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 86L Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OT5A 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AWK Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OT5B 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AWK Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OT6A 1.94 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AJK Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTDA 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AOW Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTDB 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AOW Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTHA 1.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQ8 Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTHB 1.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQ8 Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTLA 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQT Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTLB 1.57 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQT Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTOA 1.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQW Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OTOB 1.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AQW Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OUEB 2.01 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AVZ Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OUMA 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AVK Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OUUA 1.81 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AWN Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OUUB 1.81 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AWN Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6EIIA 1.935 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B5W Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6EIIB 1.935 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B5W Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7ZY5A 1.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 1NP Allosteric 2 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 9HL0A 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1IVS Allosteric 2 - 332 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6GIHA 1.96 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZN Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OSUA 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AFW Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC GSK3B GSK3B_HUMAN 9X2VA 1.39 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoii APEdist_iiii PG6 Allosteric 35 - 383 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC MAPK1 MK01_HUMAN 7W5OB 2.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 6GI Allosteric 12 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5N68A 1.85 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 8OK Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 8YD9A 1.66 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 6GI Allosteric 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3NEWA 2.51 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 3NE Allosteric 5 - 352 0 None C162S Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4E6AA 2.09 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 0O9 Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4E6CA 2.39 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 0O8 Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5N67A 1.9 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8ON Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 8X3MA 1.85 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo B8Z Allosteric 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5N64A 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8OH Allosteric 5 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4E8AA 2.7 Inactive None‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 0OA Allosteric 4 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5N63A 2.4 Inactive None‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8OW Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5O8UA 2.0 Inactive None‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 9O5 Allosteric 5 - 352 0 None S252C Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5O8VA 2.0 Inactive None‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 9O2 Allosteric 5 - 354 0 None S251C Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK8 MK08_HUMAN 3O2MA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 46A Allosteric 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 3O2MB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 46A Allosteric 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
OTHER MLKL MLKL_HUMAN 4MWIA 1.7 Pseudo DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo PXN Allosteric 193 - 470 0 None None Mixed lineage kinase domain-like protein Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YZ4A 1.7 Inactive DFGout‑None na-na out-out nonTYR APEdihe_aaoai APEdist_nnno 1E8 Allosteric 101 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE PAK2 PAK2_HUMAN 9LBGB 2.89 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aanoo APEdist_nnnn MLT Allosteric 91 - 522 0 None K278R Serine/threonine-protein kinase PAK 2 Homo sapiens
TYR ABL1 ABL1_HUMAN 2HZ4A 2.8 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4ST Allosteric 234 - 500 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 2HZ4C 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4ST Allosteric 234 - 500 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR MET MET_HUMAN 3Q6UA 1.6 Inactive DFGin‑BLBminus in-out none-none TYR APEdihe_nniai APEdist_aaai AME Allosteric 1048 - 1348 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR SRC SRC_HUMAN 9IRLA 2.031 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao A1L20 Allosteric 86 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src Homo sapiens
TYR SRC SRC_HUMAN 8JN8A 1.902 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao JA6 Allosteric 86 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src Homo sapiens
TYR SRC SRC_HUMAN 8JN9A 2.724 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao UJ0 Allosteric 86 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src Homo sapiens
OTHER BUD32 KAE1B_METJA 2VWBA 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 530 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 2VWBB 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 532 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3EN9A 2.67 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR Allosteric 1 - 534 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3EN9B 2.67 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR Allosteric 1 - 529 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
CAMK DAPK2 DAPK2_MOUSE 2YA9A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii D1D Allosteric 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YA9B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii D1D Allosteric 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R8VA 1.479 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SLV Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R8WA 1.5 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo JND Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R8XA 1.73 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SLY Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R93A 1.489 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SOJ Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R94A 1.45 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SOV Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R95A 1.59 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SQ4 Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R96A 1.767 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SQ7 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R98A 1.68 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SQG Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9AA 1.53 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SQM Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9BA 1.657 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo JGM Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9GA 1.73 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo RGY Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9HA 1.49 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SQV Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9OA 1.6 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 54F Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9SA 1.7 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo A9B Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9TA 1.8 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 6T5 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9VA 1.45 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SSY Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9XA 1.72 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo NZ4 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9ZA 1.66 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo AYS Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5RA3A 1.57 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SVD Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5RA4A 1.59 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SVG Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5RA5A 1.54 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SVJ Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SOIA 1.55 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo LOK Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SO1A 1.66 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo LO5 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SO2A 1.6 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo JGG Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SO4A 1.51 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo LO8 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SODA 1.87 Inactive DFGin‑BLBminus in-none none-out nonTYR APEdihe_aaooi APEdist_oooo LOE Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SOTA 1.54 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo LOQ Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
AGC CDC42BPA MRCKA_RAT 4AW2A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 22E Allosteric 2 - 417 0 None D254G Serine/threonine-protein kinase MRCK alpha Rattus norvegicus
OTHER RNASEL A5H025_PIG 4O1OA 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1OB 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1OC 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1OD 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER TCUR0376 D1A2F7_THECD 8CAVA 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 865 0 None None Serine/threonine protein kinase Thermomonospora curvata
OTHER TCUR0376 D1A2F7_THECD 8CAVB 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 863 0 None None Serine/threonine protein kinase Thermomonospora curvata
OTHER ROP18 ROP18_TOXGO 4JRNA 2.71 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_inni ANP Allosteric 187 - 548 0 None None Serine/threonine-protein kinase ROP18 Toxoplasma gondii

All / All / Allosteric

Total number of chains: 57
Active chains: 11
Total number of genes: 11
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 28 49.1% 5R9VA
DFGin BLAminus 18 31.6% 5N1GA
DFGin ABAminus 5 8.8% 3UTOB
DFGin None 4 7.0% 2VWBA
DFGout None 2 3.5% 8CAVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CKA1 CSK21_ARATH 9TFYA 5.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii IHP Allosteric 78 - 409 0 None None Casein kinase II subunit alpha-1 Arabidopsis thaliana
CMGC CKA1 CSK21_ARATH 9TFYB 5.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii IHP Allosteric 78 - 409 0 None None Casein kinase II subunit alpha-1 Arabidopsis thaliana
OTHER BIR2 BIR2_ARATH 4L68A 2.0 Pseudo DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiai APEdist_nioi PDO Allosteric 272 - 600 0 None None Inactive LRR receptor-like serine/threonine-protein kinase BIR2 Arabidopsis thaliana
CAMK TWITCHIN UNC22_CAEEL 3UTOB 2.4 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooo P33 Allosteric 6112 - 6675 0 None None Twitchin Caenorhabditis elegans
AGC PRKACA KAPCA_CRIGR 5N3NA 1.224 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 152 Allosteric 12 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N1GA 1.14 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 8G5 Allosteric 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N1NA 1.405 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8G8 Allosteric 1 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N3IA 1.14 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BJQ Allosteric 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N3KA 1.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii GGB Allosteric 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 5N3RA 1.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CDT Allosteric 13 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 6Z08A 1.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NPO Allosteric 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9RE2A 1.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JE1 Allosteric 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9REHA 1.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1JEO Allosteric 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9REMA 1.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JEL Allosteric 12 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9RESA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JEG Allosteric 12 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9RETA 1.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JEF Allosteric 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
OTHER BUD32 KAE1B_METJA 2VWBA 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 530 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 2VWBB 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 532 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3EN9A 2.67 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR Allosteric 1 - 534 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 3EN9B 2.67 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa TBR Allosteric 1 - 529 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
CAMK DAPK2 DAPK2_MOUSE 2YA9A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii D1D Allosteric 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YA9B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii D1D Allosteric 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R8VA 1.479 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SLV Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R8WA 1.5 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo JND Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R8XA 1.73 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SLY Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R93A 1.489 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SOJ Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R94A 1.45 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SOV Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R95A 1.59 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SQ4 Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R96A 1.767 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SQ7 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R98A 1.68 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SQG Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9AA 1.53 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SQM Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9BA 1.657 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo JGM Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9GA 1.73 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo RGY Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9HA 1.49 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo SQV Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9OA 1.6 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 54F Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9SA 1.7 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo A9B Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9TA 1.8 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 6T5 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9VA 1.45 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SSY Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9XA 1.72 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo NZ4 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5R9ZA 1.66 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo AYS Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5RA3A 1.57 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SVD Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5RA4A 1.59 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SVG Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5RA5A 1.54 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SVJ Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SOIA 1.55 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo LOK Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SO1A 1.66 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo LO5 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SO2A 1.6 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo JGG Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SO4A 1.51 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo LO8 Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SODA 1.87 Inactive DFGin‑BLBminus in-none none-out nonTYR APEdihe_aaooi APEdist_oooo LOE Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SOTA 1.54 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaooi APEdist_oooo LOQ Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
AGC CDC42BPA MRCKA_RAT 4AW2A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 22E Allosteric 2 - 417 0 None D254G Serine/threonine-protein kinase MRCK alpha Rattus norvegicus
OTHER RNASEL A5H025_PIG 4O1OA 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1OB 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1OC 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1OD 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER TCUR0376 D1A2F7_THECD 8CAVA 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 865 0 None None Serine/threonine protein kinase Thermomonospora curvata
OTHER TCUR0376 D1A2F7_THECD 8CAVB 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 863 0 None None Serine/threonine protein kinase Thermomonospora curvata
OTHER ROP18 ROP18_TOXGO 4JRNA 2.71 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_inni ANP Allosteric 187 - 548 0 None None Serine/threonine-protein kinase ROP18 Toxoplasma gondii