ALK (ALK tyrosine kinase receptor)

Group: TYR
Uniprot: ALK_HUMAN
Domain boundary: 1116 - 1385


Total number of chains: 67
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q9UM73-K1A
DFGin ABAminus 58 3LCSA
DFGin None 5 2YJRA
DFGout BBAminus 2 5IUGA
DFGout None 1 4FNYA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4TT7A 2.1 Inactive DFGin ABAminus in-in out-out COM COM Allosteric Allosteric 1095 - 1400 None None 2
7JY4A 2.42 Inactive DFGin ABAminus in-out out-out W47 W47 Allosteric Type1 1096 - 1399 None None 7
2YHVA 1.9 Inactive DFGin ABAminus in-out out-out No_ligand No_ligand 1093 - 1401 L1196M None 6
4ANLA 1.7 Inactive DFGin ABAminus in-out out-out No_ligand No_ligand 1094 - 1402 G1269A None 6
4FNWA 1.75 Inactive DFGin ABAminus in-in out-in No_ligand No_ligand 1084 - 1405 C1097S,F1174L None 8
4FNXA 1.7 Inactive DFGin ABAminus in-in out-out No_ligand No_ligand 1093 - 1404 C1097S,R1275Q None 9
6CDTA 1.8 Inactive DFGin ABAminus in-out out-in No_ligand No_ligand 1093 - 1400 None None 6
2YJSA 1.9 Inactive DFGin ABAminus in-out out-out No_ligand No_ligand 1094 - 1402 C1156Y None 8
3L9PA 1.8 Inactive DFGin ABAminus in-none out-in No_ligand No_ligand 1093 - 1400 S1281G None 0
4ANSA 1.85 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1402 L1196M,G1269A None 6
2YFXA 1.7 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1401 L1196M None 6
4CLJA 1.66 Inactive DFGin ABAminus in-in out-in 5P8 Type1 1094 - 1402 L1196M None 6
4CD0A 2.23 Inactive DFGin ABAminus in-in out-in AWJ Type1 1094 - 1402 L1196M None 6
4ANQA 1.76 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1402 G1269A None 6
5AA9A 1.93 Inactive DFGin ABAminus in-out out-out 5P8 Type1 1093 - 1402 L1198F None 6
5AAAA 1.73 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1401 L1198F None 6
5AA8A 1.86 Inactive DFGin ABAminus in-out out-out 5P8 Type1 1093 - 1402 C1156Y,L1198F None 6
5AABA 2.2 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1402 C1156Y,L1198F None 6
6MX8A 1.96 Inactive DFGin ABAminus in-in none-out 6GY Type1 1094 - 1400 None None 13
2XB7A 2.5 Inactive DFGin ABAminus in-in none-out GUI Type1 1095 - 1401 None None 14
2XBAA 1.95 Inactive DFGin ABAminus in-in out-out 571 Type1 1095 - 1402 None None 10
5FTOA 2.22 Inactive DFGin ABAminus in-in out-in YMX Type1 1094 - 1401 None None 7
5FTQA 1.7 Inactive DFGin ABAminus in-in out-in U4W Type1 1094 - 1401 None None 8
8ARJA 1.645 Inactive DFGin ABAminus in-in out-out NRR Type1 1103 - 1399 None None 8
6E0RA 2.303 Inactive DFGin ABAminus in-out out-in HKJ Type1 1099 - 1399 None None 11
6EBWA 2.455 Inactive DFGin ABAminus in-out out-in J3Y Type1 1096 - 1399 None None 14
7JYRA 2.32 Inactive DFGin ABAminus in-out out-out VTA Type1 1095 - 1399 None None 7
7JYSA 2.22 Inactive DFGin ABAminus in-in out-out VTD Type1 1095 - 1399 None None 7
7JYTA 2.0 Inactive DFGin ABAminus in-out out-out VRM Type1 1095 - 1399 None None 7
2XP2A 1.9 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1401 None None 9
4CCBA 2.03 Inactive DFGin ABAminus in-in out-in OFG Type1 1093 - 1401 None None 9
4CCUA 2.0 Inactive DFGin ABAminus in-out out-in AWF Type1 1093 - 1402 None None 6
4CLIA 2.05 Inactive DFGin ABAminus in-out out-in 5P8 Type1 1093 - 1401 None None 6
4CMOA 2.05 Inactive DFGin ABAminus in-out out-in YPW Type1 1093 - 1402 None None 6
4CMTA 1.73 Inactive DFGin ABAminus in-in out-in GWH Type1 1093 - 1401 None None 9
4CMUA 1.8 Inactive DFGin ABAminus in-out out-in IV7 Type1 1093 - 1401 None None 6
4CNHA 1.9 Inactive DFGin ABAminus in-out out-in 3U9 Type1 1094 - 1402 None None 10
4CTBA 1.79 Inactive DFGin ABAminus in-in out-out KVC Type1 1093 - 1402 None None 6
4CTCA 2.03 Inactive DFGin ABAminus in-out out-in J99 Type1 1094 - 1402 None None 8
5KZ0A 2.3 Inactive DFGin ABAminus in-out out-in 6YL Type1 1093 - 1401 None None 8
7R7KA 1.831 Inactive DFGin ABAminus in-out out-in 25J Type1 1094 - 1400 None None 6
7R7RA 1.935 Inactive DFGin ABAminus in-out out-in AWJ Type1 1093 - 1401 None None 7
4FNZA 2.6 Inactive DFGin ABAminus in-in none-in NZF Type1 1093 - 1402 C1097S None 15
5IUIA 1.88 Inactive DFGin ABAminus in-in out-out 45Q Type1 1089 - 1400 C1097S None 5
4FODA 2.0 Inactive DFGin ABAminus in-in out-in 0UV Type1 1085 - 1405 C1097S None 7
3AOXA 1.75 Inactive DFGin ABAminus in-in out-in EMH Type1 1086 - 1401 None None 7
5A9UA 1.6 Inactive DFGin ABAminus in-out out-out 5P8 Type1 1093 - 1402 C1156Y None 6
5AACA 1.7 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1402 C1156Y None 6
7BTTA 1.86 Inactive DFGin ABAminus in-in out-out F8R Type1 1093 - 1401 None None 0
4FOBA 1.9 Inactive DFGin ABAminus in-in out-in 0US Type1 1093 - 1402 C1097S None 6
4FOCA 1.7 Inactive DFGin ABAminus in-in out-in 0UU Type1 1093 - 1402 C1097S None 8
4Z55A 1.55 Inactive DFGin ABAminus in-in out-out 4LO Type1 1093 - 1399 S1281G None 1
3LCSA 1.95 Inactive DFGin ABAminus in-in out-out STU Type1 1096 - 1399 S1281G None 0
3LCTA 2.1 Inactive DFGin ABAminus in-none out-out ADP Type1 1093 - 1400 S1281G None 0
4MKCA 2.01 Inactive DFGin ABAminus in-in out-out 4MK Type1 1093 - 1401 S1281G None 0
9GBEA 1.58 Inactive DFGin ABAminus in-in out-out A1IJ8 Type1 1086 - 1401 L1196M,G1202R None 6
4CNHB 1.9 Inactive DFGin ABAminus in-in out-out 3U9 3U9 Type1 Allosteric 1093 - 1401 None None 5
4JOAA 2.7 Inactive DFGin ABAminus in-out out-out 3DK Type1.5_Front 1107 - 1398 S1281G None 9
AF-Q9UM73-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1108 - 1393 None None 0
2YJRA 1.9 Inactive DFGin None in-in none-in No_ligand No_ligand 1101 - 1402 F1174L None 14
6EDLA 2.799 Inactive DFGin None in-in none-out J4M Type1 1093 - 1399 None None 16
5IMXA 2.12 Inactive DFGin None in-in out-in CZ4 Type1 1109 - 1400 None None 10
4DCEA 2.03 Inactive DFGin None in-in none-in 0JF Type1 1093 - 1402 C1097S None 14
4DCEB 2.03 Inactive DFGin None in-in none-out 0JF Type1 1094 - 1402 C1097S None 15
5IUGA 1.93 Inactive DFGout BBAminus in-in none-out 729 Type2 1093 - 1404 C1097S None 12
5IUHA 2.1 Inactive DFGout BBAminus in-in none-out 34Y Type2 1093 - 1404 C1097S None 13
4FNYA 2.45 Inactive DFGout None in-in none-out I3K Type2 1103 - 1404 C1097S,R1275Q None 16

ALK (ALK tyrosine kinase receptor)

Group: TYR
Total number of chains: 67
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q9UM73-K1A
DFGin ABAminus 58 3LCSA
DFGin None 5 2YJRA
DFGout BBAminus 2 5IUGA
DFGout None 1 4FNYA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens ALK_HUMAN 4TT7A 2.1 Inactive DFGin ABAminus in-in out-out COM COM Allosteric Allosteric 1095 - 1400 None None 2
Homo sapiens ALK_HUMAN 7JY4A 2.42 Inactive DFGin ABAminus in-out out-out W47 W47 Allosteric Type1 1096 - 1399 None None 7
Homo sapiens ALK_HUMAN 2YHVA 1.9 Inactive DFGin ABAminus in-out out-out No_ligand No_ligand 1093 - 1401 L1196M None 6
Homo sapiens ALK_HUMAN 4ANLA 1.7 Inactive DFGin ABAminus in-out out-out No_ligand No_ligand 1094 - 1402 G1269A None 6
Homo sapiens ALK_HUMAN 4FNWA 1.75 Inactive DFGin ABAminus in-in out-in No_ligand No_ligand 1084 - 1405 C1097S,F1174L None 8
Homo sapiens ALK_HUMAN 4FNXA 1.7 Inactive DFGin ABAminus in-in out-out No_ligand No_ligand 1093 - 1404 C1097S,R1275Q None 9
Homo sapiens ALK_HUMAN 6CDTA 1.8 Inactive DFGin ABAminus in-out out-in No_ligand No_ligand 1093 - 1400 None None 6
Homo sapiens ALK_HUMAN 2YJSA 1.9 Inactive DFGin ABAminus in-out out-out No_ligand No_ligand 1094 - 1402 C1156Y None 8
Homo sapiens ALK_HUMAN 3L9PA 1.8 Inactive DFGin ABAminus in-none out-in No_ligand No_ligand 1093 - 1400 S1281G None 0
Homo sapiens ALK_HUMAN 4ANSA 1.85 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1402 L1196M,G1269A None 6
Homo sapiens ALK_HUMAN 2YFXA 1.7 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1401 L1196M None 6
Homo sapiens ALK_HUMAN 4CLJA 1.66 Inactive DFGin ABAminus in-in out-in 5P8 Type1 1094 - 1402 L1196M None 6
Homo sapiens ALK_HUMAN 4CD0A 2.23 Inactive DFGin ABAminus in-in out-in AWJ Type1 1094 - 1402 L1196M None 6
Homo sapiens ALK_HUMAN 4ANQA 1.76 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1402 G1269A None 6
Homo sapiens ALK_HUMAN 5AA9A 1.93 Inactive DFGin ABAminus in-out out-out 5P8 Type1 1093 - 1402 L1198F None 6
Homo sapiens ALK_HUMAN 5AAAA 1.73 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1401 L1198F None 6
Homo sapiens ALK_HUMAN 5AA8A 1.86 Inactive DFGin ABAminus in-out out-out 5P8 Type1 1093 - 1402 C1156Y,L1198F None 6
Homo sapiens ALK_HUMAN 5AABA 2.2 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1402 C1156Y,L1198F None 6
Homo sapiens ALK_HUMAN 6MX8A 1.96 Inactive DFGin ABAminus in-in none-out 6GY Type1 1094 - 1400 None None 13
Homo sapiens ALK_HUMAN 2XB7A 2.5 Inactive DFGin ABAminus in-in none-out GUI Type1 1095 - 1401 None None 14
Homo sapiens ALK_HUMAN 2XBAA 1.95 Inactive DFGin ABAminus in-in out-out 571 Type1 1095 - 1402 None None 10
Homo sapiens ALK_HUMAN 5FTOA 2.22 Inactive DFGin ABAminus in-in out-in YMX Type1 1094 - 1401 None None 7
Homo sapiens ALK_HUMAN 5FTQA 1.7 Inactive DFGin ABAminus in-in out-in U4W Type1 1094 - 1401 None None 8
Homo sapiens ALK_HUMAN 8ARJA 1.645 Inactive DFGin ABAminus in-in out-out NRR Type1 1103 - 1399 None None 8
Homo sapiens ALK_HUMAN 6E0RA 2.303 Inactive DFGin ABAminus in-out out-in HKJ Type1 1099 - 1399 None None 11
Homo sapiens ALK_HUMAN 6EBWA 2.455 Inactive DFGin ABAminus in-out out-in J3Y Type1 1096 - 1399 None None 14
Homo sapiens ALK_HUMAN 7JYRA 2.32 Inactive DFGin ABAminus in-out out-out VTA Type1 1095 - 1399 None None 7
Homo sapiens ALK_HUMAN 7JYSA 2.22 Inactive DFGin ABAminus in-in out-out VTD Type1 1095 - 1399 None None 7
Homo sapiens ALK_HUMAN 7JYTA 2.0 Inactive DFGin ABAminus in-out out-out VRM Type1 1095 - 1399 None None 7
Homo sapiens ALK_HUMAN 2XP2A 1.9 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1401 None None 9
Homo sapiens ALK_HUMAN 4CCBA 2.03 Inactive DFGin ABAminus in-in out-in OFG Type1 1093 - 1401 None None 9
Homo sapiens ALK_HUMAN 4CCUA 2.0 Inactive DFGin ABAminus in-out out-in AWF Type1 1093 - 1402 None None 6
Homo sapiens ALK_HUMAN 4CLIA 2.05 Inactive DFGin ABAminus in-out out-in 5P8 Type1 1093 - 1401 None None 6
Homo sapiens ALK_HUMAN 4CMOA 2.05 Inactive DFGin ABAminus in-out out-in YPW Type1 1093 - 1402 None None 6
Homo sapiens ALK_HUMAN 4CMTA 1.73 Inactive DFGin ABAminus in-in out-in GWH Type1 1093 - 1401 None None 9
Homo sapiens ALK_HUMAN 4CMUA 1.8 Inactive DFGin ABAminus in-out out-in IV7 Type1 1093 - 1401 None None 6
Homo sapiens ALK_HUMAN 4CNHA 1.9 Inactive DFGin ABAminus in-out out-in 3U9 Type1 1094 - 1402 None None 10
Homo sapiens ALK_HUMAN 4CTBA 1.79 Inactive DFGin ABAminus in-in out-out KVC Type1 1093 - 1402 None None 6
Homo sapiens ALK_HUMAN 4CTCA 2.03 Inactive DFGin ABAminus in-out out-in J99 Type1 1094 - 1402 None None 8
Homo sapiens ALK_HUMAN 5KZ0A 2.3 Inactive DFGin ABAminus in-out out-in 6YL Type1 1093 - 1401 None None 8
Homo sapiens ALK_HUMAN 7R7KA 1.831 Inactive DFGin ABAminus in-out out-in 25J Type1 1094 - 1400 None None 6
Homo sapiens ALK_HUMAN 7R7RA 1.935 Inactive DFGin ABAminus in-out out-in AWJ Type1 1093 - 1401 None None 7
Homo sapiens ALK_HUMAN 4FNZA 2.6 Inactive DFGin ABAminus in-in none-in NZF Type1 1093 - 1402 C1097S None 15
Homo sapiens ALK_HUMAN 5IUIA 1.88 Inactive DFGin ABAminus in-in out-out 45Q Type1 1089 - 1400 C1097S None 5
Homo sapiens ALK_HUMAN 4FODA 2.0 Inactive DFGin ABAminus in-in out-in 0UV Type1 1085 - 1405 C1097S None 7
Homo sapiens ALK_HUMAN 3AOXA 1.75 Inactive DFGin ABAminus in-in out-in EMH Type1 1086 - 1401 None None 7
Homo sapiens ALK_HUMAN 5A9UA 1.6 Inactive DFGin ABAminus in-out out-out 5P8 Type1 1093 - 1402 C1156Y None 6
Homo sapiens ALK_HUMAN 5AACA 1.7 Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1402 C1156Y None 6
Homo sapiens ALK_HUMAN 7BTTA 1.86 Inactive DFGin ABAminus in-in out-out F8R Type1 1093 - 1401 None None 0
Homo sapiens ALK_HUMAN 4FOBA 1.9 Inactive DFGin ABAminus in-in out-in 0US Type1 1093 - 1402 C1097S None 6
Homo sapiens ALK_HUMAN 4FOCA 1.7 Inactive DFGin ABAminus in-in out-in 0UU Type1 1093 - 1402 C1097S None 8
Homo sapiens ALK_HUMAN 4Z55A 1.55 Inactive DFGin ABAminus in-in out-out 4LO Type1 1093 - 1399 S1281G None 1
Homo sapiens ALK_HUMAN 3LCSA 1.95 Inactive DFGin ABAminus in-in out-out STU Type1 1096 - 1399 S1281G None 0
Homo sapiens ALK_HUMAN 3LCTA 2.1 Inactive DFGin ABAminus in-none out-out ADP Type1 1093 - 1400 S1281G None 0
Homo sapiens ALK_HUMAN 4MKCA 2.01 Inactive DFGin ABAminus in-in out-out 4MK Type1 1093 - 1401 S1281G None 0
Homo sapiens ALK_HUMAN 9GBEA 1.58 Inactive DFGin ABAminus in-in out-out A1IJ8 Type1 1086 - 1401 L1196M,G1202R None 6
Homo sapiens ALK_HUMAN 4CNHB 1.9 Inactive DFGin ABAminus in-in out-out 3U9 3U9 Type1 Allosteric 1093 - 1401 None None 5
Homo sapiens ALK_HUMAN 4JOAA 2.7 Inactive DFGin ABAminus in-out out-out 3DK Type1.5_Front 1107 - 1398 S1281G None 9
Homo sapiens ALK_HUMAN AF-Q9UM73-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1108 - 1393 None None 0
Homo sapiens ALK_HUMAN 2YJRA 1.9 Inactive DFGin None in-in none-in No_ligand No_ligand 1101 - 1402 F1174L None 14
Homo sapiens ALK_HUMAN 6EDLA 2.799 Inactive DFGin None in-in none-out J4M Type1 1093 - 1399 None None 16
Homo sapiens ALK_HUMAN 5IMXA 2.12 Inactive DFGin None in-in out-in CZ4 Type1 1109 - 1400 None None 10
Homo sapiens ALK_HUMAN 4DCEA 2.03 Inactive DFGin None in-in none-in 0JF Type1 1093 - 1402 C1097S None 14
Homo sapiens ALK_HUMAN 4DCEB 2.03 Inactive DFGin None in-in none-out 0JF Type1 1094 - 1402 C1097S None 15
Homo sapiens ALK_HUMAN 5IUGA 1.93 Inactive DFGout BBAminus in-in none-out 729 Type2 1093 - 1404 C1097S None 12
Homo sapiens ALK_HUMAN 5IUHA 2.1 Inactive DFGout BBAminus in-in none-out 34Y Type2 1093 - 1404 C1097S None 13
Homo sapiens ALK_HUMAN 4FNYA 2.45 Inactive DFGout None in-in none-out I3K Type2 1103 - 1404 C1097S,R1275Q None 16

ALK (ALK tyrosine kinase receptor)

No non-human structures known.