TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 68
Active chains: 2
Family: TYR
Uniprot: ALK_HUMAN
Kinase Domain Residues: 1116 - 1385
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 58 85.3% 3LCSA
DFGin None 5 7.4% 2YJRA
DFGin BLAminus 2 2.9% AF-Q9UM73-K1A
DFGout BBAminus 2 2.9% 5IUGA
DFGout None 1 1.5% 4FNYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9UM73-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1108 - 1393 0 None None ALK tyrosine kinase receptor
AF-Q9UM73-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1108 - 1393 0 None None ALK tyrosine kinase receptor
3LCTA 2.1 Inactive DFGin‑ABAminus in-none out-out TYR APEdihe_oiiai APEdist_aaao ADP ATPlike 1093 - 1400 0 None S1281G ALK tyrosine kinase receptor
4TT7A 2.1 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao COM, COM Allosteric, Allosteric 1095 - 1400 0 None None ALK tyrosine kinase receptor
7JY4A 2.42 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao W47, W47 Allosteric, Type1 1096 - 1399 0 None None ALK tyrosine kinase receptor
2YHVA 1.9 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 1093 - 1401 0 None L1196M ALK tyrosine kinase receptor
4ANLA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 1094 - 1402 0 None G1269A ALK tyrosine kinase receptor
4FNWA 1.75 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1084 - 1405 0 None C1097S,F1174L ALK tyrosine kinase receptor
4FNXA 1.7 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 1093 - 1404 0 None C1097S,R1275Q ALK tyrosine kinase receptor
6CDTA 1.8 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1093 - 1400 0 None None ALK tyrosine kinase receptor
2YJSA 1.9 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 1094 - 1402 0 None C1156Y ALK tyrosine kinase receptor
3L9PA 1.8 Inactive DFGin‑ABAminus in-none out-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1093 - 1400 0 None S1281G ALK tyrosine kinase receptor
4ANSA 1.85 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None L1196M,G1269A ALK tyrosine kinase receptor
2YFXA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1401 0 None L1196M ALK tyrosine kinase receptor
4CLJA 1.66 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 5P8 Type1 1094 - 1402 0 None L1196M ALK tyrosine kinase receptor
4CD0A 2.23 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai AWJ Type1 1094 - 1402 0 None L1196M ALK tyrosine kinase receptor
4ANQA 1.76 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None G1269A ALK tyrosine kinase receptor
5AA9A 1.93 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao 5P8 Type1 1093 - 1402 0 None L1198F ALK tyrosine kinase receptor
5AAAA 1.73 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1401 0 None L1198F ALK tyrosine kinase receptor
5AA8A 1.86 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao 5P8 Type1 1093 - 1402 0 None C1156Y,L1198F ALK tyrosine kinase receptor
5AABA 2.2 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None C1156Y,L1198F ALK tyrosine kinase receptor
6MX8A 1.96 Inactive DFGin‑ABAminus in-in none-out TYR APEdihe_oiiai APEdist_aaao 6GY Type1 1094 - 1400 0 None None ALK tyrosine kinase receptor
2XB7A 2.5 Inactive DFGin‑ABAminus in-in none-out TYR APEdihe_oiiai APEdist_aaao GUI Type1 1095 - 1401 0 None None ALK tyrosine kinase receptor
2XBAA 1.95 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 571 Type1 1095 - 1402 0 None None ALK tyrosine kinase receptor
5FTOA 2.22 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai YMX Type1 1094 - 1401 0 None None ALK tyrosine kinase receptor
5FTQA 1.7 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai U4W Type1 1094 - 1401 0 None None ALK tyrosine kinase receptor
8ARJA 1.645 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao NRR Type1 1103 - 1399 0 None None ALK tyrosine kinase receptor
6E0RA 2.303 Inactive DFGin‑ABAminus in-out out-none TYR APEdihe_niiai APEdist_aaai HKJ Type1 1099 - 1399 0 None None ALK tyrosine kinase receptor
6EBWA 2.455 Inactive DFGin‑ABAminus in-out out-none TYR APEdihe_nniai APEdist_aaai J3Y Type1 1096 - 1399 0 None None ALK tyrosine kinase receptor
7JYRA 2.32 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VTA Type1 1095 - 1399 0 None None ALK tyrosine kinase receptor
7JYSA 2.22 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao VTD Type1 1095 - 1399 0 None None ALK tyrosine kinase receptor
7JYTA 2.0 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VRM Type1 1095 - 1399 0 None None ALK tyrosine kinase receptor
2XP2A 1.9 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_niiai APEdist_aaao VGH Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
4CCBA 2.03 Inactive DFGin‑ABAminus in-in out-none TYR APEdihe_niiai APEdist_aaai OFG Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
4CCUA 2.0 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai AWF Type1 1093 - 1402 0 None None ALK tyrosine kinase receptor
4CLIA 2.05 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai 5P8 Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
4CMOA 2.05 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai YPW Type1 1093 - 1402 0 None None ALK tyrosine kinase receptor
4CMTA 1.73 Inactive DFGin‑ABAminus in-in out-none TYR APEdihe_niiai APEdist_aaai GWH Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
4CMUA 1.8 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai IV7 Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
4CNHA 1.9 Inactive DFGin‑ABAminus in-out out-none TYR APEdihe_niiai APEdist_aaai 3U9 Type1 1094 - 1402 0 None None ALK tyrosine kinase receptor
4CTBA 1.79 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao KVC Type1 1093 - 1402 0 None None ALK tyrosine kinase receptor
4CTCA 2.03 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai J99 Type1 1094 - 1402 0 None None ALK tyrosine kinase receptor
5KZ0A 2.3 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai 6YL Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
7R7KA 1.831 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai 25J Type1 1094 - 1400 0 None None ALK tyrosine kinase receptor
7R7RA 1.935 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai AWJ Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
4FNZA 2.6 Inactive DFGin‑ABAminus in-in none-out TYR APEdihe_oiiai APEdist_aaai NZF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor
5IUIA 1.88 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 45Q Type1 1089 - 1400 0 None C1097S ALK tyrosine kinase receptor
4FODA 2.0 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 0UV Type1 1085 - 1405 0 None C1097S ALK tyrosine kinase receptor
3AOXA 1.75 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai EMH Type1 1086 - 1401 0 None None ALK tyrosine kinase receptor
5A9UA 1.6 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao 5P8 Type1 1093 - 1402 0 None C1156Y ALK tyrosine kinase receptor
5AACA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None C1156Y ALK tyrosine kinase receptor
7BTTA 1.86 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao F8R Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
4FOBA 1.9 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 0US Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor
4FOCA 1.7 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 0UU Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor
4Z55A 1.55 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 4LO Type1 1093 - 1399 0 None S1281G ALK tyrosine kinase receptor
3LCSA 1.95 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao STU Type1 1096 - 1399 0 None S1281G ALK tyrosine kinase receptor
4MKCA 2.01 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 4MK Type1 1093 - 1401 0 None S1281G ALK tyrosine kinase receptor
9GBEA 1.58 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao A1IJ8 Type1 1086 - 1401 0 None L1196M,G1202R ALK tyrosine kinase receptor
4CNHB 1.9 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 3U9, 3U9 Type1, Allosteric 1093 - 1401 0 None None ALK tyrosine kinase receptor
4JOAA 2.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao 3DK Type1.5_Front 1107 - 1398 0 None S1281G ALK tyrosine kinase receptor
2YJRA 1.9 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1101 - 1402 0 None F1174L ALK tyrosine kinase receptor
6EDLA 2.799 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao J4M Type1 1093 - 1399 0 None None ALK tyrosine kinase receptor
5IMXA 2.12 Inactive DFGin‑None in-in out-out TYR APEdihe_oiiai APEdist_aaai CZ4 Type1 1109 - 1400 0 None None ALK tyrosine kinase receptor
4DCEA 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai 0JF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor
4DCEB 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao 0JF Type1 1094 - 1402 0 None C1097S ALK tyrosine kinase receptor
5IUGA 1.93 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_oiiai APEdist_aaao 729 Type2 1093 - 1404 0 None C1097S ALK tyrosine kinase receptor
5IUHA 2.1 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_oiiai APEdist_aaao 34Y Type2 1093 - 1404 0 None C1097S ALK tyrosine kinase receptor
4FNYA 2.45 Inactive DFGout‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao I3K Type2 1103 - 1404 0 None C1097S,R1275Q ALK tyrosine kinase receptor

TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 68
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 58 85.3% 3LCSA
DFGin None 5 7.4% 2YJRA
DFGin BLAminus 2 2.9% AF-Q9UM73-K1A
DFGout BBAminus 2 2.9% 5IUGA
DFGout None 1 1.5% 4FNYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ALK_HUMAN AF-Q9UM73-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1108 - 1393 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN AF-Q9UM73-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1108 - 1393 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 3LCTA 2.1 Inactive DFGin‑ABAminus in-none out-out TYR APEdihe_oiiai APEdist_aaao ADP ATPlike 1093 - 1400 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4TT7A 2.1 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao COM, COM Allosteric, Allosteric 1095 - 1400 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 7JY4A 2.42 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao W47, W47 Allosteric, Type1 1096 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 2YHVA 1.9 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 1093 - 1401 0 None L1196M ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4ANLA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 1094 - 1402 0 None G1269A ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4FNWA 1.75 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1084 - 1405 0 None C1097S,F1174L ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4FNXA 1.7 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 1093 - 1404 0 None C1097S,R1275Q ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 6CDTA 1.8 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1093 - 1400 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 2YJSA 1.9 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 1094 - 1402 0 None C1156Y ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 3L9PA 1.8 Inactive DFGin‑ABAminus in-none out-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1093 - 1400 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4ANSA 1.85 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None L1196M,G1269A ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 2YFXA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1401 0 None L1196M ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CLJA 1.66 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 5P8 Type1 1094 - 1402 0 None L1196M ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CD0A 2.23 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai AWJ Type1 1094 - 1402 0 None L1196M ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4ANQA 1.76 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None G1269A ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5AA9A 1.93 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao 5P8 Type1 1093 - 1402 0 None L1198F ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5AAAA 1.73 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1401 0 None L1198F ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5AA8A 1.86 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao 5P8 Type1 1093 - 1402 0 None C1156Y,L1198F ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5AABA 2.2 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None C1156Y,L1198F ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 6MX8A 1.96 Inactive DFGin‑ABAminus in-in none-out TYR APEdihe_oiiai APEdist_aaao 6GY Type1 1094 - 1400 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 2XB7A 2.5 Inactive DFGin‑ABAminus in-in none-out TYR APEdihe_oiiai APEdist_aaao GUI Type1 1095 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 2XBAA 1.95 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 571 Type1 1095 - 1402 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5FTOA 2.22 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai YMX Type1 1094 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5FTQA 1.7 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai U4W Type1 1094 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 8ARJA 1.645 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao NRR Type1 1103 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 6E0RA 2.303 Inactive DFGin‑ABAminus in-out out-none TYR APEdihe_niiai APEdist_aaai HKJ Type1 1099 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 6EBWA 2.455 Inactive DFGin‑ABAminus in-out out-none TYR APEdihe_nniai APEdist_aaai J3Y Type1 1096 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 7JYRA 2.32 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VTA Type1 1095 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 7JYSA 2.22 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao VTD Type1 1095 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 7JYTA 2.0 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VRM Type1 1095 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 2XP2A 1.9 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_niiai APEdist_aaao VGH Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CCBA 2.03 Inactive DFGin‑ABAminus in-in out-none TYR APEdihe_niiai APEdist_aaai OFG Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CCUA 2.0 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai AWF Type1 1093 - 1402 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CLIA 2.05 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai 5P8 Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CMOA 2.05 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai YPW Type1 1093 - 1402 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CMTA 1.73 Inactive DFGin‑ABAminus in-in out-none TYR APEdihe_niiai APEdist_aaai GWH Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CMUA 1.8 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai IV7 Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CNHA 1.9 Inactive DFGin‑ABAminus in-out out-none TYR APEdihe_niiai APEdist_aaai 3U9 Type1 1094 - 1402 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CTBA 1.79 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao KVC Type1 1093 - 1402 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CTCA 2.03 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai J99 Type1 1094 - 1402 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5KZ0A 2.3 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai 6YL Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 7R7KA 1.831 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai 25J Type1 1094 - 1400 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 7R7RA 1.935 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai AWJ Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4FNZA 2.6 Inactive DFGin‑ABAminus in-in none-out TYR APEdihe_oiiai APEdist_aaai NZF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5IUIA 1.88 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 45Q Type1 1089 - 1400 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4FODA 2.0 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 0UV Type1 1085 - 1405 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 3AOXA 1.75 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai EMH Type1 1086 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5A9UA 1.6 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao 5P8 Type1 1093 - 1402 0 None C1156Y ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5AACA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None C1156Y ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 7BTTA 1.86 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao F8R Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4FOBA 1.9 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 0US Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4FOCA 1.7 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 0UU Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4Z55A 1.55 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 4LO Type1 1093 - 1399 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 3LCSA 1.95 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao STU Type1 1096 - 1399 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4MKCA 2.01 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 4MK Type1 1093 - 1401 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 9GBEA 1.58 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao A1IJ8 Type1 1086 - 1401 0 None L1196M,G1202R ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4CNHB 1.9 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao 3U9, 3U9 Type1, Allosteric 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4JOAA 2.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao 3DK Type1.5_Front 1107 - 1398 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 2YJRA 1.9 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 1101 - 1402 0 None F1174L ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 6EDLA 2.799 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao J4M Type1 1093 - 1399 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5IMXA 2.12 Inactive DFGin‑None in-in out-out TYR APEdihe_oiiai APEdist_aaai CZ4 Type1 1109 - 1400 0 None None ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4DCEA 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai 0JF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4DCEB 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao 0JF Type1 1094 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5IUGA 1.93 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_oiiai APEdist_aaao 729 Type2 1093 - 1404 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 5IUHA 2.1 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_oiiai APEdist_aaao 34Y Type2 1093 - 1404 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
ALK_HUMAN 4FNYA 2.45 Inactive DFGout‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao I3K Type2 1103 - 1404 0 None C1097S,R1275Q ALK tyrosine kinase receptor Homo sapiens

TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism