FGFR2 (Fibroblast growth factor receptor 2)

Total number of chains: 99
Uniprot: FGFR2_HUMAN
Kinase Domain Residues: 481 - 759
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 88 AF-P21802-K1A
DFGin BLAplus 7 8W2XA
DFGin BLBminus 1 6V6QC
DFGin None 3 8STGB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
8SWEA 2.24 Inactive DFGin‑BLAminus in-in in-out GSH, WXQ Allosteric, Type1 468 - 765 0 None None Fibroblast growth factor receptor 2
4J96A 2.297 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 461 - 766 0 None C491A,K659M Fibroblast growth factor receptor 2
4J98A 2.307 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 461 - 764 0 None C491A,K659Q Fibroblast growth factor receptor 2
AF-P21802-K1A -1.0 Active DFGin‑BLAminus in-in in-in No_ligand No_ligand 473 - 767 0 None None Fibroblast growth factor receptor 2
AF-P21802-K3A -1.0 Active DFGin‑BLAminus in-in in-in No_ligand No_ligand 473 - 767 0 None None Fibroblast growth factor receptor 2
1GJOA 2.4 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 467 - 764 0 None None Fibroblast growth factor receptor 2
5UI0A 2.05 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 461 - 766 0 None C491A,E565A Fibroblast growth factor receptor 2
2PSQA 2.4 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 468 - 765 0 None None Fibroblast growth factor receptor 2
2PSQB 2.4 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 467 - 766 0 None None Fibroblast growth factor receptor 2
2PWLA 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,N549H Fibroblast growth factor receptor 2
2PWLB 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 765 0 None C491A,N549H Fibroblast growth factor receptor 2
5UGLA 1.861 Inactive DFGin‑BLAminus in-in in-out ANP Type1 468 - 764 0 None D650V Fibroblast growth factor receptor 2
5UGLB 1.861 Inactive DFGin‑BLAminus in-in in-out ANP Type1 467 - 764 11 None D650V Fibroblast growth factor receptor 2
4J96B 2.297 Inactive DFGin‑BLAminus in-out in-out ACP Type1 462 - 766 0 None C491A,K659M Fibroblast growth factor receptor 2
4J98B 2.307 Inactive DFGin‑BLAminus in-in in-out ACP Type1 461 - 764 0 None C491A,K659Q Fibroblast growth factor receptor 2
2PVFA 1.8 Active DFGin‑BLAminus in-in in-in ACP Type1 467 - 765 0 X586,X656,X657 C491A Fibroblast growth factor receptor 2
3CLYA 2.0 Active DFGin‑BLAminus in-in in-in ACP Type1 468 - 772 0 X656,X657 C491A Fibroblast growth factor receptor 2
4J99A 1.847 Inactive DFGin‑BLAminus in-in in-out ACP Type1 466 - 764 4 None C491A,K659T Fibroblast growth factor receptor 2
4J99B 1.847 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2
4J99C 1.847 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2
4J99D 1.847 Inactive DFGin‑BLAminus in-in in-out ACP Type1 465 - 764 3 None C491A,K659T Fibroblast growth factor receptor 2
2PVYA 2.2 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
2PVYB 2.2 Inactive DFGin‑BLAminus in-in in-out ACP Type1 462 - 764 6 None C491A,K659N Fibroblast growth factor receptor 2
2PVYC 2.2 Inactive DFGin‑BLAminus in-in in-out ACP Type1 462 - 764 5 None C491A,K659N Fibroblast growth factor receptor 2
2PVYD 2.2 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
4J95A 2.377 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 4 None C491A,K659N Fibroblast growth factor receptor 2
4J95B 2.377 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
4J95C 2.377 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
4J95D 2.377 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 11 None C491A,K659N Fibroblast growth factor receptor 2
2PZ5A 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,N549T Fibroblast growth factor receptor 2
2PZ5B 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,N549T Fibroblast growth factor receptor 2
4J97A 2.548 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
4J97B 2.548 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
4J97C 2.548 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
4J97D 2.548 Inactive DFGin‑BLAminus in-in in-out ACP Type1 466 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
2PZPA 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,K526E Fibroblast growth factor receptor 2
2PZPB 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,K526E Fibroblast growth factor receptor 2
2PZRA 3.0 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 765 0 None C491A,K641R Fibroblast growth factor receptor 2
2PZRB 3.0 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 766 0 None C491A,K641R Fibroblast growth factor receptor 2
5UHNA 2.909 Inactive DFGin‑BLAminus in-in in-out ACP Type1 469 - 764 0 None N549H,E565A Fibroblast growth factor receptor 2
5UHNB 2.909 Inactive DFGin‑BLAminus in-in in-out ACP Type1 469 - 764 11 None N549H,E565A Fibroblast growth factor receptor 2
3B2TA 1.8 Inactive DFGin‑BLAminus in-out in-out M33 Type1 464 - 768 0 None A628T,E767Q Fibroblast growth factor receptor 2
3B2TB 1.8 Inactive DFGin‑BLAminus in-in in-out M33 Type1 458 - 764 0 None A628T,E767Q Fibroblast growth factor receptor 2
7OZYAAA 2.28 Inactive DFGin‑BLAminus in-in in-out 47I Type1 467 - 762 0 None None Fibroblast growth factor receptor 2
7OZYBBB 2.28 Inactive DFGin‑BLAminus in-in in-out 47I Type1 467 - 762 0 None None Fibroblast growth factor receptor 2
8H75A 3.75 Inactive DFGin‑BLAminus in-out in-in KX0 Type1 467 - 765 0 X656 None Fibroblast growth factor receptor 2
8H75B 3.75 Inactive DFGin‑BLAminus in-out in-out KX0 Type1 467 - 764 0 X656 None Fibroblast growth factor receptor 2
8H75C 3.75 Inactive DFGin‑BLAminus in-in out-out KX0 Type1 467 - 763 6 X656 None Fibroblast growth factor receptor 2
8H75D 3.75 Inactive DFGin‑BLAminus in-out in-out KX0 Type1 467 - 764 4 X656 None Fibroblast growth factor receptor 2
6LVKA 2.29 Inactive DFGin‑BLAminus in-in in-out EVC Type1 468 - 766 0 X561 None Fibroblast growth factor receptor 2
6LVKB 2.29 Inactive DFGin‑BLAminus in-in in-out EVC Type1 468 - 765 0 X561 None Fibroblast growth factor receptor 2
6LVLA 2.98 Inactive DFGin‑BLAminus in-in in-out EVL Type1 468 - 766 0 None None Fibroblast growth factor receptor 2
6LVLB 2.98 Inactive DFGin‑BLAminus in-in in-out EVL Type1 468 - 765 0 None None Fibroblast growth factor receptor 2
3RI1B 2.1 Inactive DFGin‑BLAminus in-in in-out 3RH Type1 468 - 766 0 None None Fibroblast growth factor receptor 2
1OECA 2.4 Inactive DFGin‑BLAminus in-in in-out AA2 Type1 467 - 765 0 None None Fibroblast growth factor receptor 2
8SWEB 2.24 Inactive DFGin‑BLAminus in-out in-out WXQ Type1 468 - 767 0 None None Fibroblast growth factor receptor 2
5UGXA 2.349 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,E565A Fibroblast growth factor receptor 2
5UGXB 2.349 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 10 None C491A,E565A Fibroblast growth factor receptor 2
5UI0B 2.05 Inactive DFGin‑BLAminus in-in in-out ACP Type1 462 - 765 0 None C491A,E565A Fibroblast growth factor receptor 2
7KIAA 2.22 Inactive DFGin‑BLAminus in-in in-out WFD Type1 467 - 764 0 None V564F Fibroblast growth factor receptor 2
7KIAB 2.22 Inactive DFGin‑BLAminus in-in in-out WFD Type1 467 - 767 0 None V564F Fibroblast growth factor receptor 2
7KIEA 2.47 Inactive DFGin‑BLAminus in-in in-out WF7 Type1 466 - 766 0 None V564F Fibroblast growth factor receptor 2
7KIEB 2.47 Inactive DFGin‑BLAminus in-in in-out WF7 Type1 466 - 767 0 None V564F Fibroblast growth factor receptor 2
2Q0BA 2.9 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 765 0 None C491A,E565A Fibroblast growth factor receptor 2
2Q0BB 2.9 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,E565A Fibroblast growth factor receptor 2
2PY3A 2.3 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,E565G Fibroblast growth factor receptor 2
2PY3B 2.3 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,E565G Fibroblast growth factor receptor 2
5EG3A 2.606 Active DFGin‑BLAminus in-in in-in ACP Type1 466 - 774 0 X769 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E Fibroblast growth factor receptor 2
6V6QA 2.46 Inactive DFGin‑BLAminus in-in in-out ACP Type1 466 - 765 0 X656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
6V6QB 2.46 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 766 0 X656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
6V6QD 2.46 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 765 9 X656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
8W3BA 2.23 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 5 None D650V Fibroblast growth factor receptor 2
8W3BB 2.23 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 11 None D650V Fibroblast growth factor receptor 2
8W3BC 2.23 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 4 None D650V Fibroblast growth factor receptor 2
8W3BD 2.23 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 465 - 764 11 None D650V Fibroblast growth factor receptor 2
8W3DA 2.04 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 0 None N549K,D650V Fibroblast growth factor receptor 2
8W3DB 2.04 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 463 - 764 7 None N549K,D650V Fibroblast growth factor receptor 2
8W3DC 2.04 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 766 0 None N549K,D650V Fibroblast growth factor receptor 2
8W3DD 2.04 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 463 - 765 2 None N549K,D650V Fibroblast growth factor receptor 2
6AGXA 2.95 Inactive DFGin‑BLAminus in-out in-in 9WX Type1.5_Back 467 - 764 5 X586,X588,X656,X657 A628T Fibroblast growth factor receptor 2
6AGXB 2.95 Inactive DFGin‑BLAminus in-out in-out 9WX Type1.5_Back 467 - 764 0 X586,X588,X656,X657 A628T Fibroblast growth factor receptor 2
6AGXC 2.95 Inactive DFGin‑BLAminus in-out in-in 9WX Type1.5_Back 467 - 764 5 X586,X588,X656,X657 A628T Fibroblast growth factor receptor 2
6AGXD 2.95 Inactive DFGin‑BLAminus in-out in-out 9WX Type1.5_Back 467 - 764 0 X586,X588,X656,X657 A628T Fibroblast growth factor receptor 2
3RI1A 2.1 Inactive DFGin‑BLAminus in-in in-out 3RH Type1.5_Back 468 - 765 0 None None Fibroblast growth factor receptor 2
8W38A 2.6 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2
8W38B 2.6 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 6 None N549D,D650V Fibroblast growth factor receptor 2
8W38C 2.6 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 465 - 764 11 None N549D,D650V Fibroblast growth factor receptor 2
8W38D 2.6 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 11 None N549D,D650V Fibroblast growth factor receptor 2
8E1XA 2.68 Inactive DFGin‑BLAplus in-in out-out U9P Type1 468 - 762 5 X561,X586 None Fibroblast growth factor receptor 2
8E1XB 2.68 Inactive DFGin‑BLAplus in-in out-out U9P Type1 467 - 765 2 X561,X586 None Fibroblast growth factor receptor 2
8STGA 3.79 Inactive DFGin‑BLAplus in-out none-none WCJ Type1 461 - 764 17 None None Fibroblast growth factor receptor 2
9U3NA 3.25 Inactive DFGin‑BLAplus in-out none-in A1ENT Type1 461 - 764 15 None V564F Fibroblast growth factor receptor 2
8W2XA 2.98 Inactive DFGin‑BLAplus in-in out-out A1AFR Type1.5_Back 458 - 765 0 None None Fibroblast growth factor receptor 2
8W2XB 2.98 Inactive DFGin‑BLAplus in-in out-out A1AFR Type1.5_Back 458 - 765 3 None None Fibroblast growth factor receptor 2
8U1FA 3.33 Inactive DFGin‑BLAplus in-out none-none UIM Type1.5_Back 460 - 764 17 None None Fibroblast growth factor receptor 2
6V6QC 2.46 Inactive DFGin‑BLBminus in-in in-out ACP Type1 467 - 766 11 X656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
8U1FB 3.33 Inactive DFGin‑None in-out none-out UIM Type1.5_Back 472 - 765 16 None None Fibroblast growth factor receptor 2
8STGB 3.79 Inactive DFGin‑None in-out none-out WCJ Type1.5_Back 472 - 765 10 None None Fibroblast growth factor receptor 2
9U3NB 3.25 Inactive DFGin‑None in-in none-out A1ENT Type1.5_Back 470 - 764 13 None V564F Fibroblast growth factor receptor 2

FGFR2 (Fibroblast growth factor receptor 2)

Total number of chains: 99
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 88 AF-P21802-K1A
DFGin BLAplus 7 8W2XA
DFGin BLBminus 1 6V6QC
DFGin None 3 8STGB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
Homo sapiens FGFR2_HUMAN 8SWEA 2.24 Inactive DFGin‑BLAminus in-in in-out GSH, WXQ Allosteric, Type1 468 - 765 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J96A 2.297 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 461 - 766 0 None C491A,K659M Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J98A 2.307 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 461 - 764 0 None C491A,K659Q Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN AF-P21802-K1A -1.0 Active DFGin‑BLAminus in-in in-in No_ligand No_ligand 473 - 767 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN AF-P21802-K3A -1.0 Active DFGin‑BLAminus in-in in-in No_ligand No_ligand 473 - 767 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 1GJOA 2.4 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 467 - 764 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5UI0A 2.05 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 461 - 766 0 None C491A,E565A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PSQA 2.4 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 468 - 765 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PSQB 2.4 Inactive DFGin‑BLAminus in-in in-out No_ligand No_ligand 467 - 766 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PWLA 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,N549H Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PWLB 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 765 0 None C491A,N549H Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5UGLA 1.861 Inactive DFGin‑BLAminus in-in in-out ANP Type1 468 - 764 0 None D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5UGLB 1.861 Inactive DFGin‑BLAminus in-in in-out ANP Type1 467 - 764 11 None D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J96B 2.297 Inactive DFGin‑BLAminus in-out in-out ACP Type1 462 - 766 0 None C491A,K659M Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J98B 2.307 Inactive DFGin‑BLAminus in-in in-out ACP Type1 461 - 764 0 None C491A,K659Q Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PVFA 1.8 Active DFGin‑BLAminus in-in in-in ACP Type1 467 - 765 0 X586,X656,X657 C491A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 3CLYA 2.0 Active DFGin‑BLAminus in-in in-in ACP Type1 468 - 772 0 X656,X657 C491A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J99A 1.847 Inactive DFGin‑BLAminus in-in in-out ACP Type1 466 - 764 4 None C491A,K659T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J99B 1.847 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J99C 1.847 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J99D 1.847 Inactive DFGin‑BLAminus in-in in-out ACP Type1 465 - 764 3 None C491A,K659T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PVYA 2.2 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PVYB 2.2 Inactive DFGin‑BLAminus in-in in-out ACP Type1 462 - 764 6 None C491A,K659N Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PVYC 2.2 Inactive DFGin‑BLAminus in-in in-out ACP Type1 462 - 764 5 None C491A,K659N Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PVYD 2.2 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J95A 2.377 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 4 None C491A,K659N Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J95B 2.377 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J95C 2.377 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J95D 2.377 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 11 None C491A,K659N Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PZ5A 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,N549T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PZ5B 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,N549T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J97A 2.548 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J97B 2.548 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J97C 2.548 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 4J97D 2.548 Inactive DFGin‑BLAminus in-in in-out ACP Type1 466 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PZPA 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,K526E Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PZPB 2.4 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,K526E Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PZRA 3.0 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 765 0 None C491A,K641R Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PZRB 3.0 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 766 0 None C491A,K641R Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5UHNA 2.909 Inactive DFGin‑BLAminus in-in in-out ACP Type1 469 - 764 0 None N549H,E565A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5UHNB 2.909 Inactive DFGin‑BLAminus in-in in-out ACP Type1 469 - 764 11 None N549H,E565A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 3B2TA 1.8 Inactive DFGin‑BLAminus in-out in-out M33 Type1 464 - 768 0 None A628T,E767Q Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 3B2TB 1.8 Inactive DFGin‑BLAminus in-in in-out M33 Type1 458 - 764 0 None A628T,E767Q Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 7OZYAAA 2.28 Inactive DFGin‑BLAminus in-in in-out 47I Type1 467 - 762 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 7OZYBBB 2.28 Inactive DFGin‑BLAminus in-in in-out 47I Type1 467 - 762 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8H75A 3.75 Inactive DFGin‑BLAminus in-out in-in KX0 Type1 467 - 765 0 X656 None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8H75B 3.75 Inactive DFGin‑BLAminus in-out in-out KX0 Type1 467 - 764 0 X656 None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8H75C 3.75 Inactive DFGin‑BLAminus in-in out-out KX0 Type1 467 - 763 6 X656 None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8H75D 3.75 Inactive DFGin‑BLAminus in-out in-out KX0 Type1 467 - 764 4 X656 None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6LVKA 2.29 Inactive DFGin‑BLAminus in-in in-out EVC Type1 468 - 766 0 X561 None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6LVKB 2.29 Inactive DFGin‑BLAminus in-in in-out EVC Type1 468 - 765 0 X561 None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6LVLA 2.98 Inactive DFGin‑BLAminus in-in in-out EVL Type1 468 - 766 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6LVLB 2.98 Inactive DFGin‑BLAminus in-in in-out EVL Type1 468 - 765 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 3RI1B 2.1 Inactive DFGin‑BLAminus in-in in-out 3RH Type1 468 - 766 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 1OECA 2.4 Inactive DFGin‑BLAminus in-in in-out AA2 Type1 467 - 765 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8SWEB 2.24 Inactive DFGin‑BLAminus in-out in-out WXQ Type1 468 - 767 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5UGXA 2.349 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 0 None C491A,E565A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5UGXB 2.349 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 764 10 None C491A,E565A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5UI0B 2.05 Inactive DFGin‑BLAminus in-in in-out ACP Type1 462 - 765 0 None C491A,E565A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 7KIAA 2.22 Inactive DFGin‑BLAminus in-in in-out WFD Type1 467 - 764 0 None V564F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 7KIAB 2.22 Inactive DFGin‑BLAminus in-in in-out WFD Type1 467 - 767 0 None V564F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 7KIEA 2.47 Inactive DFGin‑BLAminus in-in in-out WF7 Type1 466 - 766 0 None V564F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 7KIEB 2.47 Inactive DFGin‑BLAminus in-in in-out WF7 Type1 466 - 767 0 None V564F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2Q0BA 2.9 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 765 0 None C491A,E565A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2Q0BB 2.9 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,E565A Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PY3A 2.3 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,E565G Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 2PY3B 2.3 Inactive DFGin‑BLAminus in-in in-out ACP Type1 468 - 766 0 None C491A,E565G Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 5EG3A 2.606 Active DFGin‑BLAminus in-in in-in ACP Type1 466 - 774 0 X769 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6V6QA 2.46 Inactive DFGin‑BLAminus in-in in-out ACP Type1 466 - 765 0 X656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6V6QB 2.46 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 766 0 X656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6V6QD 2.46 Inactive DFGin‑BLAminus in-in in-out ACP Type1 467 - 765 9 X656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W3BA 2.23 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 5 None D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W3BB 2.23 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 11 None D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W3BC 2.23 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 4 None D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W3BD 2.23 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 465 - 764 11 None D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W3DA 2.04 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 0 None N549K,D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W3DB 2.04 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 463 - 764 7 None N549K,D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W3DC 2.04 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 766 0 None N549K,D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W3DD 2.04 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 463 - 765 2 None N549K,D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6AGXA 2.95 Inactive DFGin‑BLAminus in-out in-in 9WX Type1.5_Back 467 - 764 5 X586,X588,X656,X657 A628T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6AGXB 2.95 Inactive DFGin‑BLAminus in-out in-out 9WX Type1.5_Back 467 - 764 0 X586,X588,X656,X657 A628T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6AGXC 2.95 Inactive DFGin‑BLAminus in-out in-in 9WX Type1.5_Back 467 - 764 5 X586,X588,X656,X657 A628T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6AGXD 2.95 Inactive DFGin‑BLAminus in-out in-out 9WX Type1.5_Back 467 - 764 0 X586,X588,X656,X657 A628T Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 3RI1A 2.1 Inactive DFGin‑BLAminus in-in in-out 3RH Type1.5_Back 468 - 765 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W38A 2.6 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W38B 2.6 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 6 None N549D,D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W38C 2.6 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 465 - 764 11 None N549D,D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W38D 2.6 Inactive DFGin‑BLAminus in-in in-out TZ0 Type1.5_Back 467 - 764 11 None N549D,D650V Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8E1XA 2.68 Inactive DFGin‑BLAplus in-in out-out U9P Type1 468 - 762 5 X561,X586 None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8E1XB 2.68 Inactive DFGin‑BLAplus in-in out-out U9P Type1 467 - 765 2 X561,X586 None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8STGA 3.79 Inactive DFGin‑BLAplus in-out none-none WCJ Type1 461 - 764 17 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 9U3NA 3.25 Inactive DFGin‑BLAplus in-out none-in A1ENT Type1 461 - 764 15 None V564F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W2XA 2.98 Inactive DFGin‑BLAplus in-in out-out A1AFR Type1.5_Back 458 - 765 0 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8W2XB 2.98 Inactive DFGin‑BLAplus in-in out-out A1AFR Type1.5_Back 458 - 765 3 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8U1FA 3.33 Inactive DFGin‑BLAplus in-out none-none UIM Type1.5_Back 460 - 764 17 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 6V6QC 2.46 Inactive DFGin‑BLBminus in-in in-out ACP Type1 467 - 766 11 X656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8U1FB 3.33 Inactive DFGin‑None in-out none-out UIM Type1.5_Back 472 - 765 16 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 8STGB 3.79 Inactive DFGin‑None in-out none-out WCJ Type1.5_Back 472 - 765 10 None None Fibroblast growth factor receptor 2
Homo sapiens FGFR2_HUMAN 9U3NB 3.25 Inactive DFGin‑None in-in none-out A1ENT Type1.5_Back 470 - 764 13 None V564F Fibroblast growth factor receptor 2

FGFR2 (Fibroblast growth factor receptor 2)

Total number of chains: 0
Spatial label Dihedral label Number of Chains Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein