Protein kinases in complex with I46

Total number of genes: 1
Total number of chains: 10
Spatial Dihedral Chains Representative
DFGin BLBplus 2 3HL7A
DFGin None 2 3HP2A
DFGout BBAminus 3 3K3IA
DFGout None 3 3K3JA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3HL7A 1.88 Inactive DFGin BLBplus in-in none-out I47 I46 Type1 Allosteric
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3HLLA 1.95 Inactive DFGin BLBplus in-out none-out I45 I46 PO2 Type1 Allosteric Allosteric
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3HP2A 2.15 Inactive DFGin None in-in none-out P36 I46 I46 Type1 Allosteric Allosteric
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3HP5A 2.3 Inactive DFGin None in-in none-out 52P I46 I46 Type1 Allosteric Allosteric
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 6QDZA 1.73 Inactive DFGout BBAminus in-in none-out I46 HYK Allosteric Type2
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 6QE1A 1.85 Inactive DFGout BBAminus in-in none-out I46 HYW Allosteric Type2
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3K3IA 1.7 Inactive DFGout BBAminus in-in none-out JZJ I46 I46 Type3 Allosteric Allosteric
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 2YISA 2.0 Inactive DFGout None in-in none-out YIS I46 Type2 Allosteric
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 2YIWA 2.0 Inactive DFGout None in-in none-out YIW I46 Type2 Allosteric
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3K3JA 1.995 Inactive DFGout None in-in none-out F4C I46 Type2 Allosteric

Protein kinases in complex with I46

Total number of genes: 1
Total number of chains: 10
Spatial Dihedral Chains Representative
DFGin BLBplus 2 3HL7A
DFGin None 2 3HP2A
DFGout BBAminus 3 3K3IA
DFGout None 3 3K3JA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3HL7A 1.88 Inactive DFGin BLBplus in-in none-out I47 I46 Type1 Allosteric
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3HLLA 1.95 Inactive DFGin BLBplus in-out none-out I45 I46 PO2 Type1 Allosteric Allosteric
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3HP2A 2.15 Inactive DFGin None in-in none-out P36 I46 I46 Type1 Allosteric Allosteric
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3HP5A 2.3 Inactive DFGin None in-in none-out 52P I46 I46 Type1 Allosteric Allosteric
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 6QDZA 1.73 Inactive DFGout BBAminus in-in none-out I46 HYK Allosteric Type2
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 6QE1A 1.85 Inactive DFGout BBAminus in-in none-out I46 HYW Allosteric Type2
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3K3IA 1.7 Inactive DFGout BBAminus in-in none-out JZJ I46 I46 Type3 Allosteric Allosteric
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 2YISA 2.0 Inactive DFGout None in-in none-out YIS I46 Type2 Allosteric
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 2YIWA 2.0 Inactive DFGout None in-in none-out YIW I46 Type2 Allosteric
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3K3JA 1.995 Inactive DFGout None in-in none-out F4C I46 Type2 Allosteric

Protein kinases in complex with I46

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type