TKL_MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

Total number of chains: 14
Active chains: 2
Uniprot: M3K12_HUMAN
Kinase Domain Residues: 125 - 366
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 10 71.4% 9CDYA
DFGin BLAminus 2 14.3% AF-Q12852-K1A
DFGin BLBminus 1 7.1% 5CENA
DFGin None 1 7.1% 9CDXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q12852-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 117 - 374 0 None None Mitogen-activated protein kinase kinase kinase 12
AF-Q12852-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 117 - 374 0 None None Mitogen-activated protein kinase kinase kinase 12
5CENA 1.7 Inactive DFGin‑BLBminus out-na out-out nonTYR APEdihe_aaooi APEdist_iioo No_ligand No_ligand 117 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12
5CEOA 2.28 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 50D Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12
5CEPA 1.99 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 50E Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12
5CEQA 1.911 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 50F Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12
5VO1A 2.45 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 9FS Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12
5VO2A 2.96 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 9FV Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12
8OURA 1.95 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno W38 Type1 118 - 396 0 None None Mitogen-activated protein kinase kinase kinase 12
8OUSA 2.2 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno W3I Type1 118 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12
8OUTA 1.935 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno W3C Type1 118 - 399 0 None None Mitogen-activated protein kinase kinase kinase 12
9CDYA 1.5 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaooi APEdist_nnoo A1AZ8 Type1 117 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12
8DEGA 2.79 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno SIQ Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12
9CDXA 2.38 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaooi APEdist_nnno A1AZP Type1 117 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12

TKL_MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

Total number of chains: 14
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 10 71.4% 9CDYA
DFGin BLAminus 2 14.3% AF-Q12852-K1A
DFGin BLBminus 1 7.1% 5CENA
DFGin None 1 7.1% 9CDXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
M3K12_HUMAN AF-Q12852-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 117 - 374 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN AF-Q12852-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 117 - 374 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 5CENA 1.7 Inactive DFGin‑BLBminus out-na out-out nonTYR APEdihe_aaooi APEdist_iioo No_ligand No_ligand 117 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 5CEOA 2.28 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 50D Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 5CEPA 1.99 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 50E Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 5CEQA 1.911 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 50F Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 5VO1A 2.45 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 9FS Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 5VO2A 2.96 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 9FV Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 8OURA 1.95 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno W38 Type1 118 - 396 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 8OUSA 2.2 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno W3I Type1 118 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 8OUTA 1.935 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno W3C Type1 118 - 399 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 9CDYA 1.5 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaooi APEdist_nnoo A1AZ8 Type1 117 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 8DEGA 2.79 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno SIQ Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
M3K12_HUMAN 9CDXA 2.38 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaooi APEdist_nnno A1AZP Type1 117 - 397 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens

TKL_MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism