8R9B

CDK7 (Cyclin-dependent kinase 7)
Group: CMGC
Uniprot: CDK7_HUMAN
Organism: Homo sapiens
Domain boundary: 12 - 296
Resolu: 2.21

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None out-out out-out ANP Type1 1 - 311 0
B Inactive DFGin None out-out out-out ANP Type1 3 - 310 0
C Inactive DFGin None out-out out-out ANP Type1 8 - 311 12
D Inactive DFGin None out-out out-out ANP Type1 9 - 311 10
Representative sequence - Chain D
- - 4 14
imsyyhhhhh hdydiptten lyfqgsmald vksrAKRYEK
24 34 44 54
LDFLGEGQFA TVYKARDKNT NQIVAIKKIk lghrseakdg
64 74 84 94
inrTALREIK LLQELSHPNI IGLLDAFGhk SNISLVFDFM
104 114 124 134
ETDLEVIIKD NSLVLTPSHI KAYMLMTLQG LEYLHQHWIL
144 154 164 174
HRDLKPNNLL LDENGVLKLA DFGLAKSFgd pnrayehqVV
184 194 204 214
TRWYRAPELL FGARMYGVGV DMWAVGCILA ELLLRVPFLP
224 234 244 254
GDSDLDQLTR IFETLGTPTE EQWPDMCSLP DYVTFKSFPG
264 274 284 294
IPLHHIFSAA GDDLLDLIQG LFLFNPCARI TATQALKMKY
304 314 324
FSNRPGPTPG CQLPRPNcpv etlkeqsnpa la
Lower-case residues are disordered in structure.
Mutations: S164D,T170E
Phosphorylation: None