KDR (Vascular endothelial growth factor receptor 2)

Group: TYR
Uniprot: VGFR2_HUMAN
Domain boundary: 834 - 1162


Total number of chains: 53
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P35968-K1A
DFGin BLAplus 1 2P2HA
DFGin BLBplus 3 3WZDA
DFGin None 1 1VR2A
DFGinter None 2 1Y6BA
DFGout BBAminus 32 6GQQA
DFGout None 9 3VO3A
None None 3 3CJFA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P35968-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 826 - 1170 None None 0
3CJGA 2.25 None DFGin BLAminus in-in in-none KIM Type1 816 - 1168 None None 14
2P2HA 1.95 Inactive DFGin BLAplus in-in none-out 994 Type1 815 - 1172 C817A,V916T,E990V X1054,X1059 15
3WZDA 1.57 Inactive DFGin BLBplus in-in none-out LEV Type1 820 - 1167 T940V None 16
3B8RA 2.7 Inactive DFGin BLBplus in-in none-out 887 Type1 818 - 1171 C817A,V916T,E990V X1054,X1059 17
3B8RB 2.7 Inactive DFGin BLBplus in-in none-out 887 Type1 821 - 1166 C817A,V916T,E990V X1054,X1059 17
1VR2A 2.4 Inactive DFGin None in-in none-out No_ligand No_ligand 820 - 1168 E990V X1059 16
1Y6AA 2.1 Inactive DFGinter None in-in none-none AAZ Type1 820 - 1167 None None 20
1Y6BA 2.1 Inactive DFGinter None in-in none-none AAX Type1 819 - 1168 None None 20
4AG8A 1.95 Inactive DFGout BBAminus in-in out-in AXI Type1 816 - 1168 E990V None 0
4AGDA 2.81 Inactive DFGout BBAminus in-in out-in B49 Type1 802 - 1169 E990V None 0
3CPBB 2.7 Inactive DFGout BBAminus in-in none-out C92 Type1 820 - 1165 C817A,V916T,E990V X1054,X1059 18
2XIRA 1.5 Inactive DFGout BBAminus in-in out-in 00J Type1.5_Back 816 - 1168 E990V None 0
4AGCA 2.0 Inactive DFGout BBAminus in-in out-in AXI Type1.5_Back 801 - 1169 E990V None 0
3WZEA 1.9 Inactive DFGout BBAminus in-in out-out BAX Type2 815 - 1167 T940V None 1
2OH4A 2.05 Inactive DFGout BBAminus in-in out-out GIG Type2 816 - 1171 None X1054,X1059 0
2P2IA 2.4 Inactive DFGout BBAminus in-in none-out 608 Type2 817 - 1172 C817A,E990V X1054,X1059 16
3EFLA 2.2 Inactive DFGout BBAminus in-in none-none 706 Type2 817 - 1171 C817A,E990V X1054,X1059 19
3EFLB 2.2 Inactive DFGout BBAminus in-in none-out 706 Type2 821 - 1165 C817A,E990V X1054,X1059 18
5EW3A 2.5 Inactive DFGout BBAminus in-in none-out 5T2 Type2 821 - 1168 None None 18
5EW3B 2.5 Inactive DFGout BBAminus in-in none-out 5T2 Type2 820 - 1165 None None 18
6GQOA 1.87 Inactive DFGout BBAminus in-in out-in F82 Type2 811 - 1168 None None 0
6GQPA 2.09 Inactive DFGout BBAminus in-in out-out F88 Type2 821 - 1168 None None 0
6GQQA 1.52 Inactive DFGout BBAminus in-in out-out F8B Type2 813 - 1167 None None 0
6XVJA 1.78 Inactive DFGout BBAminus in-in out-in O35 Type2 813 - 1167 E990V None 0
6XVKA 1.99 Inactive DFGout BBAminus in-in out-in O3E Type2 821 - 1168 E990V None 0
4ASDA 2.03 Inactive DFGout BBAminus in-in out-in BAX Type2 807 - 1168 E990V None 0
4ASEA 1.83 Inactive DFGout BBAminus in-in out-in AV9 Type2 807 - 1169 E990V None 0
3VHEA 1.55 Inactive DFGout BBAminus in-in out-out 42Q Type2 811 - 1169 None None 2
3VHKA 2.49 Inactive DFGout BBAminus in-in out-out BPK Type2 814 - 1168 None None 2
2QU5A 2.95 Inactive DFGout BBAminus in-in none-out 276 Type2 816 - 1170 C817A,V916T,E990V X1054,X1059 13
2QU6A 2.1 Inactive DFGout BBAminus in-in none-none 857 Type2 817 - 1171 C817A,V916T,E990V X1054,X1059 19
2RL5A 2.65 Inactive DFGout BBAminus in-in none-out 2RL Type2 815 - 1171 C817A,V916T,E990V X1054,X1059 14
3B8QB 2.75 Inactive DFGout BBAminus in-in none-out 900 Type2 820 - 1166 C817A,V916T,E990V X1054,X1059 18
3BE2A 1.75 Inactive DFGout BBAminus in-in none-none RAJ Type2 815 - 1171 C817A,V916T,E990V X1054,X1059 19
3CP9A 2.5 Inactive DFGout BBAminus in-in none-out C19 Type2 817 - 1171 C817A,V916T,E990V X1054,X1059 18
3CP9B 2.5 Inactive DFGout BBAminus in-in none-out C19 Type2 819 - 1165 C817A,V916T,E990V X1054,X1059 17
3CPCB 2.4 Inactive DFGout BBAminus in-in none-out C52 Type2 820 - 1165 C817A,V916T,E990V X1054,X1059 18
3DTWB 2.9 Inactive DFGout BBAminus in-in none-out A96 Type2 820 - 1166 C817A,V916T,E990V X1054,X1059 16
3EWHA 1.6 Inactive DFGout BBAminus in-in out-in K11 Type2 815 - 1171 C817A,V916T,E990V None 9
3U6JA 2.15 Inactive DFGout BBAminus in-in out-in 03X Type2 815 - 1171 V916T,E990V None 0
3C7QA 2.1 Inactive DFGout None in-in none-out XIN Type1 819 - 1171 None X1054,X1059 4
2P2IB 2.4 Inactive DFGout None in-in none-none 608 Type1 820 - 1168 C817A,E990V X1054,X1059 20
3VNTA 1.64 Inactive DFGout None in-in out-in 0JA Type2 812 - 1168 None None 0
3VO3A 1.52 Inactive DFGout None in-in out-in 0KF Type2 812 - 1168 None None 0
2QU6B 2.1 Inactive DFGout None in-in none-out 857 Type2 822 - 1165 C817A,V916T,E990V X1054,X1059 19
3B8QA 2.75 Inactive DFGout None in-in none-out 900 Type2 818 - 1171 C817A,V916T,E990V X1054,X1059 19
3CPBA 2.7 Inactive DFGout None in-in none-out C92 Type2 819 - 1171 C817A,V916T,E990V X1054,X1059 19
3CPCA 2.4 Inactive DFGout None in-out none-out C52 Type2 820 - 1171 C817A,V916T,E990V X1054,X1059 19
3DTWA 2.9 Inactive DFGout None in-in none-out A96 Type2 818 - 1171 C817A,V916T,E990V X1054,X1059 19
3CJFA 2.15 Inactive None None in-out in-none SAV Type1 817 - 1168 None None 14
1YWNA 1.71 Inactive None None in-in none-out LIF Type1 820 - 1171 E990V X1054,X1059 6
3VIDA 2.3 Inactive None None in-in none-out 4TT Type1 813 - 1168 None None 7

KDR (Vascular endothelial growth factor receptor 2)

Group: TYR
Total number of chains: 53
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P35968-K1A
DFGin BLAplus 1 2P2HA
DFGin BLBplus 3 3WZDA
DFGin None 1 1VR2A
DFGinter None 2 1Y6BA
DFGout BBAminus 32 6GQQA
DFGout None 9 3VO3A
None None 3 3CJFA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens VGFR2_HUMAN AF-P35968-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 826 - 1170 None None 0
Homo sapiens VGFR2_HUMAN 3CJGA 2.25 None DFGin BLAminus in-in in-none KIM Type1 816 - 1168 None None 14
Homo sapiens VGFR2_HUMAN 2P2HA 1.95 Inactive DFGin BLAplus in-in none-out 994 Type1 815 - 1172 C817A,V916T,E990V X1054,X1059 15
Homo sapiens VGFR2_HUMAN 3WZDA 1.57 Inactive DFGin BLBplus in-in none-out LEV Type1 820 - 1167 T940V None 16
Homo sapiens VGFR2_HUMAN 3B8RA 2.7 Inactive DFGin BLBplus in-in none-out 887 Type1 818 - 1171 C817A,V916T,E990V X1054,X1059 17
Homo sapiens VGFR2_HUMAN 3B8RB 2.7 Inactive DFGin BLBplus in-in none-out 887 Type1 821 - 1166 C817A,V916T,E990V X1054,X1059 17
Homo sapiens VGFR2_HUMAN 1VR2A 2.4 Inactive DFGin None in-in none-out No_ligand No_ligand 820 - 1168 E990V X1059 16
Homo sapiens VGFR2_HUMAN 1Y6AA 2.1 Inactive DFGinter None in-in none-none AAZ Type1 820 - 1167 None None 20
Homo sapiens VGFR2_HUMAN 1Y6BA 2.1 Inactive DFGinter None in-in none-none AAX Type1 819 - 1168 None None 20
Homo sapiens VGFR2_HUMAN 4AG8A 1.95 Inactive DFGout BBAminus in-in out-in AXI Type1 816 - 1168 E990V None 0
Homo sapiens VGFR2_HUMAN 4AGDA 2.81 Inactive DFGout BBAminus in-in out-in B49 Type1 802 - 1169 E990V None 0
Homo sapiens VGFR2_HUMAN 3CPBB 2.7 Inactive DFGout BBAminus in-in none-out C92 Type1 820 - 1165 C817A,V916T,E990V X1054,X1059 18
Homo sapiens VGFR2_HUMAN 2XIRA 1.5 Inactive DFGout BBAminus in-in out-in 00J Type1.5_Back 816 - 1168 E990V None 0
Homo sapiens VGFR2_HUMAN 4AGCA 2.0 Inactive DFGout BBAminus in-in out-in AXI Type1.5_Back 801 - 1169 E990V None 0
Homo sapiens VGFR2_HUMAN 3WZEA 1.9 Inactive DFGout BBAminus in-in out-out BAX Type2 815 - 1167 T940V None 1
Homo sapiens VGFR2_HUMAN 2OH4A 2.05 Inactive DFGout BBAminus in-in out-out GIG Type2 816 - 1171 None X1054,X1059 0
Homo sapiens VGFR2_HUMAN 2P2IA 2.4 Inactive DFGout BBAminus in-in none-out 608 Type2 817 - 1172 C817A,E990V X1054,X1059 16
Homo sapiens VGFR2_HUMAN 3EFLA 2.2 Inactive DFGout BBAminus in-in none-none 706 Type2 817 - 1171 C817A,E990V X1054,X1059 19
Homo sapiens VGFR2_HUMAN 3EFLB 2.2 Inactive DFGout BBAminus in-in none-out 706 Type2 821 - 1165 C817A,E990V X1054,X1059 18
Homo sapiens VGFR2_HUMAN 5EW3A 2.5 Inactive DFGout BBAminus in-in none-out 5T2 Type2 821 - 1168 None None 18
Homo sapiens VGFR2_HUMAN 5EW3B 2.5 Inactive DFGout BBAminus in-in none-out 5T2 Type2 820 - 1165 None None 18
Homo sapiens VGFR2_HUMAN 6GQOA 1.87 Inactive DFGout BBAminus in-in out-in F82 Type2 811 - 1168 None None 0
Homo sapiens VGFR2_HUMAN 6GQPA 2.09 Inactive DFGout BBAminus in-in out-out F88 Type2 821 - 1168 None None 0
Homo sapiens VGFR2_HUMAN 6GQQA 1.52 Inactive DFGout BBAminus in-in out-out F8B Type2 813 - 1167 None None 0
Homo sapiens VGFR2_HUMAN 6XVJA 1.78 Inactive DFGout BBAminus in-in out-in O35 Type2 813 - 1167 E990V None 0
Homo sapiens VGFR2_HUMAN 6XVKA 1.99 Inactive DFGout BBAminus in-in out-in O3E Type2 821 - 1168 E990V None 0
Homo sapiens VGFR2_HUMAN 4ASDA 2.03 Inactive DFGout BBAminus in-in out-in BAX Type2 807 - 1168 E990V None 0
Homo sapiens VGFR2_HUMAN 4ASEA 1.83 Inactive DFGout BBAminus in-in out-in AV9 Type2 807 - 1169 E990V None 0
Homo sapiens VGFR2_HUMAN 3VHEA 1.55 Inactive DFGout BBAminus in-in out-out 42Q Type2 811 - 1169 None None 2
Homo sapiens VGFR2_HUMAN 3VHKA 2.49 Inactive DFGout BBAminus in-in out-out BPK Type2 814 - 1168 None None 2
Homo sapiens VGFR2_HUMAN 2QU5A 2.95 Inactive DFGout BBAminus in-in none-out 276 Type2 816 - 1170 C817A,V916T,E990V X1054,X1059 13
Homo sapiens VGFR2_HUMAN 2QU6A 2.1 Inactive DFGout BBAminus in-in none-none 857 Type2 817 - 1171 C817A,V916T,E990V X1054,X1059 19
Homo sapiens VGFR2_HUMAN 2RL5A 2.65 Inactive DFGout BBAminus in-in none-out 2RL Type2 815 - 1171 C817A,V916T,E990V X1054,X1059 14
Homo sapiens VGFR2_HUMAN 3B8QB 2.75 Inactive DFGout BBAminus in-in none-out 900 Type2 820 - 1166 C817A,V916T,E990V X1054,X1059 18
Homo sapiens VGFR2_HUMAN 3BE2A 1.75 Inactive DFGout BBAminus in-in none-none RAJ Type2 815 - 1171 C817A,V916T,E990V X1054,X1059 19
Homo sapiens VGFR2_HUMAN 3CP9A 2.5 Inactive DFGout BBAminus in-in none-out C19 Type2 817 - 1171 C817A,V916T,E990V X1054,X1059 18
Homo sapiens VGFR2_HUMAN 3CP9B 2.5 Inactive DFGout BBAminus in-in none-out C19 Type2 819 - 1165 C817A,V916T,E990V X1054,X1059 17
Homo sapiens VGFR2_HUMAN 3CPCB 2.4 Inactive DFGout BBAminus in-in none-out C52 Type2 820 - 1165 C817A,V916T,E990V X1054,X1059 18
Homo sapiens VGFR2_HUMAN 3DTWB 2.9 Inactive DFGout BBAminus in-in none-out A96 Type2 820 - 1166 C817A,V916T,E990V X1054,X1059 16
Homo sapiens VGFR2_HUMAN 3EWHA 1.6 Inactive DFGout BBAminus in-in out-in K11 Type2 815 - 1171 C817A,V916T,E990V None 9
Homo sapiens VGFR2_HUMAN 3U6JA 2.15 Inactive DFGout BBAminus in-in out-in 03X Type2 815 - 1171 V916T,E990V None 0
Homo sapiens VGFR2_HUMAN 3C7QA 2.1 Inactive DFGout None in-in none-out XIN Type1 819 - 1171 None X1054,X1059 4
Homo sapiens VGFR2_HUMAN 2P2IB 2.4 Inactive DFGout None in-in none-none 608 Type1 820 - 1168 C817A,E990V X1054,X1059 20
Homo sapiens VGFR2_HUMAN 3VNTA 1.64 Inactive DFGout None in-in out-in 0JA Type2 812 - 1168 None None 0
Homo sapiens VGFR2_HUMAN 3VO3A 1.52 Inactive DFGout None in-in out-in 0KF Type2 812 - 1168 None None 0
Homo sapiens VGFR2_HUMAN 2QU6B 2.1 Inactive DFGout None in-in none-out 857 Type2 822 - 1165 C817A,V916T,E990V X1054,X1059 19
Homo sapiens VGFR2_HUMAN 3B8QA 2.75 Inactive DFGout None in-in none-out 900 Type2 818 - 1171 C817A,V916T,E990V X1054,X1059 19
Homo sapiens VGFR2_HUMAN 3CPBA 2.7 Inactive DFGout None in-in none-out C92 Type2 819 - 1171 C817A,V916T,E990V X1054,X1059 19
Homo sapiens VGFR2_HUMAN 3CPCA 2.4 Inactive DFGout None in-out none-out C52 Type2 820 - 1171 C817A,V916T,E990V X1054,X1059 19
Homo sapiens VGFR2_HUMAN 3DTWA 2.9 Inactive DFGout None in-in none-out A96 Type2 818 - 1171 C817A,V916T,E990V X1054,X1059 19
Homo sapiens VGFR2_HUMAN 3CJFA 2.15 Inactive None None in-out in-none SAV Type1 817 - 1168 None None 14
Homo sapiens VGFR2_HUMAN 1YWNA 1.71 Inactive None None in-in none-out LIF Type1 820 - 1171 E990V X1054,X1059 6
Homo sapiens VGFR2_HUMAN 3VIDA 2.3 Inactive None None in-in none-out 4TT Type1 813 - 1168 None None 7

KDR (Vascular endothelial growth factor receptor 2)

No non-human structures known.