Protein kinases in complex with 4SP

Total number of genes: 4
Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 12 1H1SA
DFGin None 2 6BSSA
None None 1 2C6OA
All chains
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All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CMGC CDK1 CDK1_HUMAN Cyclin-dependent kinase 1 5LQFA 2.06 Inactive DFGin BLAminus in-in in-out 4SP Type1
CMGC CDK1 CDK1_HUMAN Cyclin-dependent kinase 1 5LQFD 2.06 None DFGin BLAminus in-in in-none 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2IW9A 2.0 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2IW9C 2.0 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4EORA 2.2 Inactive DFGin BLAminus in-out in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4EORC 2.2 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 1H1SA 2.0 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 1H1SC 2.0 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4EOKA 2.57 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4EOKC 2.57 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2IW8A 2.3 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2IW8C 2.3 Active DFGin BLAminus in-in in-in 4SP Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2C6OA 2.1 Inactive None None out-out out-out 4SP Type1
NEK NEK2 NEK2_HUMAN Serine/threonine-protein kinase Nek2 5M57A 2.3 Inactive DFGin None out-none none-out 4SP Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6BSSA 2.1 Inactive DFGin None in-none out-out 4SP Type1

Protein kinases in complex with 4SP

Total number of genes: 4
Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 12 1H1SA
DFGin None 2 6BSSA
None None 1 2C6OA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CMGC CDK1 CDK1_HUMAN Cyclin-dependent kinase 1 5LQFA 2.06 Inactive DFGin BLAminus in-in in-out 4SP Type1
Homo sapiens CMGC CDK1 CDK1_HUMAN Cyclin-dependent kinase 1 5LQFD 2.06 None DFGin BLAminus in-in in-none 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2IW9A 2.0 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2IW9C 2.0 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4EORA 2.2 Inactive DFGin BLAminus in-out in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4EORC 2.2 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 1H1SA 2.0 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 1H1SC 2.0 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4EOKA 2.57 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4EOKC 2.57 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2IW8A 2.3 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2IW8C 2.3 Active DFGin BLAminus in-in in-in 4SP Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2C6OA 2.1 Inactive None None out-out out-out 4SP Type1
Homo sapiens NEK NEK2 NEK2_HUMAN Serine/threonine-protein kinase Nek2 5M57A 2.3 Inactive DFGin None out-none none-out 4SP Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6BSSA 2.1 Inactive DFGin None in-none out-out 4SP Type1

Protein kinases in complex with 4SP

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type