CDK4 (Cyclin-dependent kinase 4)

Group: CMGC
Uniprot: CDK4_HUMAN
Domain boundary: 6 - 295


Total number of chains: 18
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P11802-K1A
DFGin BLAplus 2 3G33A
DFGin BLBplus 7 2W99B
DFGin None 3 2W9FB
None None 4 5FWMK
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P11802-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 303 None None 0
7SJ3A 2.51 Active DFGin BLAminus in-in in-in 6ZV Type1 2 - 295 None X172 0
3G33A 3.0 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 5 - 295 None None 0
3G33C 3.0 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 5 - 295 None None 0
6P8GB 2.8 Inactive DFGin BLBplus out-out none-out No_ligand No_ligand 18 - 299 G43E,G47E None 14
6P8HB 3.19 Inactive DFGin BLBplus out-out none-none No_ligand No_ligand 18 - 298 None None 15
2W99B 2.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 2 - 295 G43E,G47E,T172A None 0
2W9ZB 2.45 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 2 - 295 G43E,G47E,T172A None 0
2W96B 2.3 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 4 - 295 G43E,G47E,T172D None 0
9CSKB 2.253 Inactive DFGin BLBplus out-none out-out A1AZ4 Type1 4 - 295 G43E,G47E None 7
9CSKD 2.253 Inactive DFGin BLBplus out-out out-out A1AZ4 Type1 4 - 295 G43E,G47E None 6
6P8EB 2.3 Inactive DFGin None out-out none-none No_ligand No_ligand 18 - 299 G43E,G47E None 15
6P8FB 2.89 Inactive DFGin None out-out none-out No_ligand No_ligand 18 - 299 G43E,G47E None 13
2W9FB 2.85 Inactive DFGin None out-out out-none No_ligand No_ligand 5 - 295 G43E,G47E,T172F None 6
5FWKK 3.9 Inactive None None none-none out-out No_ligand No_ligand 87 - 296 None None 0
5FWLK 9.0 Inactive None None in-out out-out No_ligand No_ligand 5 - 295 None None 0
5FWMK 8.0 Inactive None None in-out out-out No_ligand No_ligand 5 - 295 None None 0
5FWPK 7.2 Inactive None None none-none out-out No_ligand No_ligand 87 - 295 None None 0

CDK4 (Cyclin-dependent kinase 4)

Group: CMGC
Total number of chains: 18
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P11802-K1A
DFGin BLAplus 2 3G33A
DFGin BLBplus 7 2W99B
DFGin None 3 2W9FB
None None 4 5FWMK
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CDK4_HUMAN AF-P11802-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 303 None None 0
Homo sapiens CDK4_HUMAN 7SJ3A 2.51 Active DFGin BLAminus in-in in-in 6ZV Type1 2 - 295 None X172 0
Homo sapiens CDK4_HUMAN 3G33A 3.0 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 5 - 295 None None 0
Homo sapiens CDK4_HUMAN 3G33C 3.0 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 5 - 295 None None 0
Homo sapiens CDK4_HUMAN 6P8GB 2.8 Inactive DFGin BLBplus out-out none-out No_ligand No_ligand 18 - 299 G43E,G47E None 14
Homo sapiens CDK4_HUMAN 6P8HB 3.19 Inactive DFGin BLBplus out-out none-none No_ligand No_ligand 18 - 298 None None 15
Homo sapiens CDK4_HUMAN 2W99B 2.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 2 - 295 G43E,G47E,T172A None 0
Homo sapiens CDK4_HUMAN 2W9ZB 2.45 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 2 - 295 G43E,G47E,T172A None 0
Homo sapiens CDK4_HUMAN 2W96B 2.3 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 4 - 295 G43E,G47E,T172D None 0
Homo sapiens CDK4_HUMAN 9CSKB 2.253 Inactive DFGin BLBplus out-none out-out A1AZ4 Type1 4 - 295 G43E,G47E None 7
Homo sapiens CDK4_HUMAN 9CSKD 2.253 Inactive DFGin BLBplus out-out out-out A1AZ4 Type1 4 - 295 G43E,G47E None 6
Homo sapiens CDK4_HUMAN 6P8EB 2.3 Inactive DFGin None out-out none-none No_ligand No_ligand 18 - 299 G43E,G47E None 15
Homo sapiens CDK4_HUMAN 6P8FB 2.89 Inactive DFGin None out-out none-out No_ligand No_ligand 18 - 299 G43E,G47E None 13
Homo sapiens CDK4_HUMAN 2W9FB 2.85 Inactive DFGin None out-out out-none No_ligand No_ligand 5 - 295 G43E,G47E,T172F None 6
Homo sapiens CDK4_HUMAN 5FWKK 3.9 Inactive None None none-none out-out No_ligand No_ligand 87 - 296 None None 0
Homo sapiens CDK4_HUMAN 5FWLK 9.0 Inactive None None in-out out-out No_ligand No_ligand 5 - 295 None None 0
Homo sapiens CDK4_HUMAN 5FWMK 8.0 Inactive None None in-out out-out No_ligand No_ligand 5 - 295 None None 0
Homo sapiens CDK4_HUMAN 5FWPK 7.2 Inactive None None none-none out-out No_ligand No_ligand 87 - 295 None None 0

CDK4 (Cyclin-dependent kinase 4)

No non-human structures known.