AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 25
Active chains: 15
Uniprot: GRK5_HUMAN
Kinase Domain Residues: 186 - 448
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 64.0% AF-P34947-K1A
DFGin None 5 20.0% 6PJXA
DFGin ABAminus 4 16.0% 9BRKA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
4TNDA 1.802 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 543 0 None None G protein-coupled receptor kinase 5
9CKRA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9CKSA 3.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AF-P34947-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 178 - 456 0 None None G protein-coupled receptor kinase 5
AF-P34947-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 178 - 456 0 None None G protein-coupled receptor kinase 5
9CKQA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 25 - 542 0 None D311N G protein-coupled receptor kinase 5
4TNBA 2.113 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 15 - 543 0 None None G protein-coupled receptor kinase 5
8UAPA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W2T Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BREA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRGA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ6 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRHA 3.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ7 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRMA 2.73 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARC Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRNA 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARD Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BROA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARE Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9CKPA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None D311N G protein-coupled receptor kinase 5
9CKOA 2.8 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None None G protein-coupled receptor kinase 5
9BRKA 2.7 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARA Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRLA 2.73 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARB Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRPA 2.8 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARF Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9MX2A 3.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None D311N G protein-coupled receptor kinase 5
6PJXA 1.96 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None E104K,R304H,G438E G protein-coupled receptor kinase 5
8UAQA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRFA 2.84 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ5 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRIA 2.9 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ8 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
9BRJA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ9 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5

AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 26
Active chains: 15
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 61.5% AF-P34947-K1A
DFGin ABAminus 5 19.2% 4WNKA
DFGin None 5 19.2% 6PJXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
GRK5_BOVIN 4WNKA 2.42 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1.5_Front 24 - 541 0 None None G protein-coupled receptor kinase 5 Bos taurus
GRK5_HUMAN 4TNDA 1.802 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 543 0 None None G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9CKRA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9CKSA 3.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN AF-P34947-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 178 - 456 0 None None G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN AF-P34947-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 178 - 456 0 None None G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9CKQA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 4TNBA 2.113 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 15 - 543 0 None None G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 8UAPA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W2T Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BREA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRGA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ6 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRHA 3.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ7 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRMA 2.73 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARC Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRNA 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARD Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BROA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARE Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9CKPA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9CKOA 2.8 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None None G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRKA 2.7 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARA Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRLA 2.73 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARB Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRPA 2.8 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARF Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9MX2A 3.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 6PJXA 1.96 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None E104K,R304H,G438E G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 8UAQA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRFA 2.84 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ5 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRIA 2.9 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ8 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
GRK5_HUMAN 9BRJA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AQ9 Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens

AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 100.0% 4WNKA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
GRK5_BOVIN 4WNKA 2.42 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1.5_Front 24 - 541 0 None None G protein-coupled receptor kinase 5 Bos taurus