GRK5 (G protein-coupled receptor kinase 5)

Group: AGC

Uniprot: GRK5_HUMAN

Domain boundary: 186 - 448

Total number of chains: 12

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	7	AF-P34947-K1A
DFGin	None	5	6PJXA

Database table as tsv

PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
AF-P34947-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	178 - 456	None	None	0
4TNBA	2.113	Active	DFGin	BLAminus	in-in	in-in	SGV	Type1	15 - 543	None	None	0
4TNDA	1.802	Active	DFGin	BLAminus	in-in	in-in	ANP	Type1	15 - 543	None	None	0
8UAPA	2.5	Active	DFGin	BLAminus	in-in	in-in	W2T	Type1	25 - 542	D311N	None	0
9BREA	2.8	Active	DFGin	BLAminus	in-in	in-in	W3F	Type1	25 - 542	D311N	None	0
9BRGA	2.7	Active	DFGin	BLAminus	in-in	in-in	A1AQ6	Type1	25 - 542	D311N	None	0
9BRHA	3.69	Active	DFGin	BLAminus	in-in	in-in	A1AQ7	Type1	25 - 542	D311N	None	0
6PJXA	1.96	Inactive	DFGin	None	in-in	in-in	SGV	Type1	1 - 542	E104K,R304H,G438E	None	0
8UAQA	2.8	Inactive	DFGin	None	in-in	in-in	W3F	Type1	25 - 542	D311N	None	0
9BRFA	2.84	Inactive	DFGin	None	in-in	in-in	A1AQ5	Type1	25 - 542	D311N	None	0
9BRIA	2.9	Inactive	DFGin	None	in-in	in-in	A1AQ8	Type1	25 - 542	D311N	None	0
9BRJA	2.8	Inactive	DFGin	None	in-in	in-in	A1AQ9	Type1	25 - 542	D311N	None	0

GRK5 (G protein-coupled receptor kinase 5)

Group: AGC

Total number of chains: 13

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	7	AF-P34947-K1A
DFGin	ABAminus	1	4WNKA
DFGin	None	5	6PJXA

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Bos taurus	GRK5_BOVIN	4WNKA	2.42	Inactive	DFGin	ABAminus	in-in	in-in	453	Type1.5_Front	24 - 541	None	None	0
Homo sapiens	GRK5_HUMAN	AF-P34947-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	178 - 456	None	None	0
Homo sapiens	GRK5_HUMAN	4TNBA	2.113	Active	DFGin	BLAminus	in-in	in-in	SGV	Type1	15 - 543	None	None	0
Homo sapiens	GRK5_HUMAN	4TNDA	1.802	Active	DFGin	BLAminus	in-in	in-in	ANP	Type1	15 - 543	None	None	0
Homo sapiens	GRK5_HUMAN	8UAPA	2.5	Active	DFGin	BLAminus	in-in	in-in	W2T	Type1	25 - 542	D311N	None	0
Homo sapiens	GRK5_HUMAN	9BREA	2.8	Active	DFGin	BLAminus	in-in	in-in	W3F	Type1	25 - 542	D311N	None	0
Homo sapiens	GRK5_HUMAN	9BRGA	2.7	Active	DFGin	BLAminus	in-in	in-in	A1AQ6	Type1	25 - 542	D311N	None	0
Homo sapiens	GRK5_HUMAN	9BRHA	3.69	Active	DFGin	BLAminus	in-in	in-in	A1AQ7	Type1	25 - 542	D311N	None	0
Homo sapiens	GRK5_HUMAN	6PJXA	1.96	Inactive	DFGin	None	in-in	in-in	SGV	Type1	1 - 542	E104K,R304H,G438E	None	0
Homo sapiens	GRK5_HUMAN	8UAQA	2.8	Inactive	DFGin	None	in-in	in-in	W3F	Type1	25 - 542	D311N	None	0
Homo sapiens	GRK5_HUMAN	9BRFA	2.84	Inactive	DFGin	None	in-in	in-in	A1AQ5	Type1	25 - 542	D311N	None	0
Homo sapiens	GRK5_HUMAN	9BRIA	2.9	Inactive	DFGin	None	in-in	in-in	A1AQ8	Type1	25 - 542	D311N	None	0
Homo sapiens	GRK5_HUMAN	9BRJA	2.8	Inactive	DFGin	None	in-in	in-in	A1AQ9	Type1	25 - 542	D311N	None	0

GRK5 (G protein-coupled receptor kinase 5)

Group: AGC

Total number of chains: 1

Spatial	Dihedral	Chains	Representative
DFGin	ABAminus	1	4WNKA

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Bos taurus	GRK5_BOVIN	4WNKA	2.42	Inactive	DFGin	ABAminus	in-in	in-in	453	Type1.5_Front	24 - 541	None	None	0