NTRK1 (High affinity nerve growth factor receptor)

Group: TYR
Uniprot: NTRK1_HUMAN
Domain boundary: 510 - 783


Total number of chains: 62
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P04629-K1A
DFGin ABAminus 6 7VKNA
DFGin None 8 7VKOA
DFGout BBAminus 17 8J5XA
DFGout None 27 4F0IB
None None 3 4YPSA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
5KVTA 2.45 Inactive DFGin ABAminus in-in out-in YMX Type1 501 - 787 None None 0
6IQNB 2.54 Inactive DFGin ABAminus out-out none-in AQ6 Type1 502 - 788 None None 18
4YNEA 2.023 Inactive DFGin ABAminus in-out none-in 4EK Type1 502 - 793 None None 9
4AOJA 2.75 Inactive DFGin ABAminus in-in none-in V4Z Type1 500 - 789 None None 16
4AOJC 2.75 Inactive DFGin ABAminus in-out none-in V4Z Type1 500 - 789 None None 16
7VKNA 2.7 Inactive DFGin ABAminus in-out out-in 7GI Type1 502 - 794 G595R None 1
AF-P04629-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 502 - 791 None None 0
4PMTA 2.1 Inactive DFGin None in-out out-in 31Y Type1 501 - 787 None None 5
5I8AA 2.33 Inactive DFGin None in-in out-in 69C Type1 501 - 787 None None 4
6IQNA 2.54 Inactive DFGin None in-out none-in AQ6 Type1 502 - 790 None None 12
7XAFA 3.001 Inactive DFGin None in-out out-in FKT Type1 498 - 796 None None 0
6J5LA 2.3 Inactive DFGin None in-in none-in B9C Type1 502 - 790 None None 7
6PMEB 3.0 Inactive DFGin None in-out out-in OOY Type1 499 - 791 None X677 5
7VKOA 2.9 Inactive DFGin None in-out out-in 7GI Type1 502 - 793 None None 0
4AOJB 2.75 Inactive DFGin None in-out none-in V4Z Type1 500 - 791 None None 19
6DKGA 2.53 Inactive DFGout BBAminus in-out none-in 22L GO7 Allosteric Type2 500 - 796 None None 9
6DKIA 2.11 Inactive DFGout BBAminus in-out out-in 22L GOD Allosteric Type2 500 - 796 None None 6
6D1ZA 1.87 Inactive DFGout BBAminus in-out out-in FQD FQM Allosteric Type3 483 - 796 None None 4
7VKMA 2.55 Inactive DFGout BBAminus in-out out-in No_ligand No_ligand 502 - 795 G595R None 0
4PMPA 1.8 Inactive DFGout BBAminus in-out out-in 31W Type1 501 - 787 None None 3
5H3QA 2.1 Inactive DFGout BBAminus in-out out-in 7HF Type1 484 - 796 None None 0
4PMMA 2.0 Inactive DFGout BBAminus in-out out-in 31V Type2 501 - 787 None None 0
5JFSA 2.07 Inactive DFGout BBAminus in-in none-in 6K0 Type2 502 - 793 None None 18
5JFVA 1.59 Inactive DFGout BBAminus out-out none-in 6K1 Type2 502 - 793 None None 18
5JFWA 1.52 Inactive DFGout BBAminus out-out none-in 6K2 Type2 502 - 793 None None 18
5JFXA 1.63 Inactive DFGout BBAminus out-in none-in 6K4 Type2 502 - 793 None None 18
6DKWA 2.91 Inactive DFGout BBAminus out-out none-in GXA Type2 502 - 793 None None 18
6DKWB 2.91 Inactive DFGout BBAminus in-out none-in GXA Type2 502 - 793 None None 16
6PL2A 2.59 Inactive DFGout BBAminus in-out out-in OOM Type2 499 - 795 None X677 0
7XBIA 2.16 Inactive DFGout BBAminus in-out out-in CVY Type2 497 - 795 None None 0
8J5XA 2.092 Inactive DFGout BBAminus in-in out-in A4U Type2 500 - 795 G595R None 0
6PL4A 2.06 Inactive DFGout BBAminus in-out out-in OO7 Type3 485 - 795 None X677 0
6D20A 1.94 Inactive DFGout None out-out out-in FQD FQG Allosteric Type3 482 - 796 None None 2
4F0IA 2.302 Inactive DFGout None out-out out-in No_ligand No_ligand 501 - 790 None None 0
4F0IB 2.302 Inactive DFGout None in-out out-in No_ligand No_ligand 501 - 794 None None 0
4GT5A 2.398 Inactive DFGout None in-none out-in No_ligand No_ligand 498 - 793 None None 0
6D22A 2.46 Inactive DFGout None in-out out-in No_ligand No_ligand 502 - 794 None None 0
6DKBA 2.68 Inactive DFGout None out-in none-in FKY Type1 501 - 796 None None 11
5KMOA 2.67 Inactive DFGout None out-out out-in 6UM Type1 500 - 796 None None 2
4PMSA 2.8 Inactive DFGout None in-out out-in 31X Type1.5_Back 501 - 787 None None 2
8J5WA 2.28 Inactive DFGout None in-out out-in A4U Type2 485 - 795 F589L None 0
8J61A 3.051 Inactive DFGout None out-out out-in A0X Type2 499 - 795 None None 0
8J63A 3.001 Inactive DFGout None in-out out-in A6X Type2 500 - 796 None None 0
5WR7A 2.76 Inactive DFGout None out-out out-in RCH Type2 489 - 792 None X677 2
6PL1A 2.03 Inactive DFGout None in-out out-in OOJ Type2 500 - 795 None X677 3
6PL3A 3.0 Inactive DFGout None in-out out-in OOD Type2 500 - 795 None None 0
6PMAA 2.53 Inactive DFGout None in-in out-in OQS Type2 500 - 795 None X677 0
6PMBA 2.81 Inactive DFGout None in-in out-in OQM Type2 500 - 795 None None 0
6PMCA 2.19 Inactive DFGout None in-in out-in OQJ Type2 500 - 795 None X677 0
6NSPA 2.31 Inactive DFGout None in-out out-in L0P Type3 500 - 795 None None 0
6NPTA 2.19 Inactive DFGout None out-out out-in KWY Type3 491 - 795 None X677 0
6NSSA 1.97 Inactive DFGout None in-out out-in L0M Type3 485 - 795 None None 0
6D1YA 1.93 Inactive DFGout None out-out out-in FQJ Type3 481 - 796 None None 4
5KMIA 1.87 Inactive DFGout None in-out out-in 6UE Type3 486 - 796 None None 0
5KMJA 2.04 Inactive DFGout None in-in out-in 6UF Type3 486 - 795 None None 0
5KMKA 2.24 Inactive DFGout None in-out out-in 6UG Type3 484 - 796 None None 0
5KMMA 2.12 Inactive DFGout None in-out out-in 6UJ Type3 484 - 796 None None 0
5KMLA 2.01 Inactive DFGout None in-out out-in 6UH Type3 474 - 796 None None 0
5KMNA 2.14 Inactive DFGout None in-out out-in 6UK Type3 474 - 796 None None 0
4YPSA 2.101 Inactive None None out-out out-in 4F6 Type1 502 - 790 None None 5
6PMEA 3.0 Inactive None None in-out out-in OOY Type1 500 - 788 None X677 3
6PMEC 3.0 Inactive None None in-out out-in OOY Type1 500 - 790 None X677 2

NTRK1 (High affinity nerve growth factor receptor)

Group: TYR
Total number of chains: 62
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P04629-K1A
DFGin ABAminus 6 7VKNA
DFGin None 8 7VKOA
DFGout BBAminus 17 8J5XA
DFGout None 27 4F0IB
None None 3 4YPSA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens NTRK1_HUMAN 5KVTA 2.45 Inactive DFGin ABAminus in-in out-in YMX Type1 501 - 787 None None 0
Homo sapiens NTRK1_HUMAN 6IQNB 2.54 Inactive DFGin ABAminus out-out none-in AQ6 Type1 502 - 788 None None 18
Homo sapiens NTRK1_HUMAN 4YNEA 2.023 Inactive DFGin ABAminus in-out none-in 4EK Type1 502 - 793 None None 9
Homo sapiens NTRK1_HUMAN 4AOJA 2.75 Inactive DFGin ABAminus in-in none-in V4Z Type1 500 - 789 None None 16
Homo sapiens NTRK1_HUMAN 4AOJC 2.75 Inactive DFGin ABAminus in-out none-in V4Z Type1 500 - 789 None None 16
Homo sapiens NTRK1_HUMAN 7VKNA 2.7 Inactive DFGin ABAminus in-out out-in 7GI Type1 502 - 794 G595R None 1
Homo sapiens NTRK1_HUMAN AF-P04629-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 502 - 791 None None 0
Homo sapiens NTRK1_HUMAN 4PMTA 2.1 Inactive DFGin None in-out out-in 31Y Type1 501 - 787 None None 5
Homo sapiens NTRK1_HUMAN 5I8AA 2.33 Inactive DFGin None in-in out-in 69C Type1 501 - 787 None None 4
Homo sapiens NTRK1_HUMAN 6IQNA 2.54 Inactive DFGin None in-out none-in AQ6 Type1 502 - 790 None None 12
Homo sapiens NTRK1_HUMAN 7XAFA 3.001 Inactive DFGin None in-out out-in FKT Type1 498 - 796 None None 0
Homo sapiens NTRK1_HUMAN 6J5LA 2.3 Inactive DFGin None in-in none-in B9C Type1 502 - 790 None None 7
Homo sapiens NTRK1_HUMAN 6PMEB 3.0 Inactive DFGin None in-out out-in OOY Type1 499 - 791 None X677 5
Homo sapiens NTRK1_HUMAN 7VKOA 2.9 Inactive DFGin None in-out out-in 7GI Type1 502 - 793 None None 0
Homo sapiens NTRK1_HUMAN 4AOJB 2.75 Inactive DFGin None in-out none-in V4Z Type1 500 - 791 None None 19
Homo sapiens NTRK1_HUMAN 6DKGA 2.53 Inactive DFGout BBAminus in-out none-in 22L GO7 Allosteric Type2 500 - 796 None None 9
Homo sapiens NTRK1_HUMAN 6DKIA 2.11 Inactive DFGout BBAminus in-out out-in 22L GOD Allosteric Type2 500 - 796 None None 6
Homo sapiens NTRK1_HUMAN 6D1ZA 1.87 Inactive DFGout BBAminus in-out out-in FQD FQM Allosteric Type3 483 - 796 None None 4
Homo sapiens NTRK1_HUMAN 7VKMA 2.55 Inactive DFGout BBAminus in-out out-in No_ligand No_ligand 502 - 795 G595R None 0
Homo sapiens NTRK1_HUMAN 4PMPA 1.8 Inactive DFGout BBAminus in-out out-in 31W Type1 501 - 787 None None 3
Homo sapiens NTRK1_HUMAN 5H3QA 2.1 Inactive DFGout BBAminus in-out out-in 7HF Type1 484 - 796 None None 0
Homo sapiens NTRK1_HUMAN 4PMMA 2.0 Inactive DFGout BBAminus in-out out-in 31V Type2 501 - 787 None None 0
Homo sapiens NTRK1_HUMAN 5JFSA 2.07 Inactive DFGout BBAminus in-in none-in 6K0 Type2 502 - 793 None None 18
Homo sapiens NTRK1_HUMAN 5JFVA 1.59 Inactive DFGout BBAminus out-out none-in 6K1 Type2 502 - 793 None None 18
Homo sapiens NTRK1_HUMAN 5JFWA 1.52 Inactive DFGout BBAminus out-out none-in 6K2 Type2 502 - 793 None None 18
Homo sapiens NTRK1_HUMAN 5JFXA 1.63 Inactive DFGout BBAminus out-in none-in 6K4 Type2 502 - 793 None None 18
Homo sapiens NTRK1_HUMAN 6DKWA 2.91 Inactive DFGout BBAminus out-out none-in GXA Type2 502 - 793 None None 18
Homo sapiens NTRK1_HUMAN 6DKWB 2.91 Inactive DFGout BBAminus in-out none-in GXA Type2 502 - 793 None None 16
Homo sapiens NTRK1_HUMAN 6PL2A 2.59 Inactive DFGout BBAminus in-out out-in OOM Type2 499 - 795 None X677 0
Homo sapiens NTRK1_HUMAN 7XBIA 2.16 Inactive DFGout BBAminus in-out out-in CVY Type2 497 - 795 None None 0
Homo sapiens NTRK1_HUMAN 8J5XA 2.092 Inactive DFGout BBAminus in-in out-in A4U Type2 500 - 795 G595R None 0
Homo sapiens NTRK1_HUMAN 6PL4A 2.06 Inactive DFGout BBAminus in-out out-in OO7 Type3 485 - 795 None X677 0
Homo sapiens NTRK1_HUMAN 6D20A 1.94 Inactive DFGout None out-out out-in FQD FQG Allosteric Type3 482 - 796 None None 2
Homo sapiens NTRK1_HUMAN 4F0IA 2.302 Inactive DFGout None out-out out-in No_ligand No_ligand 501 - 790 None None 0
Homo sapiens NTRK1_HUMAN 4F0IB 2.302 Inactive DFGout None in-out out-in No_ligand No_ligand 501 - 794 None None 0
Homo sapiens NTRK1_HUMAN 4GT5A 2.398 Inactive DFGout None in-none out-in No_ligand No_ligand 498 - 793 None None 0
Homo sapiens NTRK1_HUMAN 6D22A 2.46 Inactive DFGout None in-out out-in No_ligand No_ligand 502 - 794 None None 0
Homo sapiens NTRK1_HUMAN 6DKBA 2.68 Inactive DFGout None out-in none-in FKY Type1 501 - 796 None None 11
Homo sapiens NTRK1_HUMAN 5KMOA 2.67 Inactive DFGout None out-out out-in 6UM Type1 500 - 796 None None 2
Homo sapiens NTRK1_HUMAN 4PMSA 2.8 Inactive DFGout None in-out out-in 31X Type1.5_Back 501 - 787 None None 2
Homo sapiens NTRK1_HUMAN 8J5WA 2.28 Inactive DFGout None in-out out-in A4U Type2 485 - 795 F589L None 0
Homo sapiens NTRK1_HUMAN 8J61A 3.051 Inactive DFGout None out-out out-in A0X Type2 499 - 795 None None 0
Homo sapiens NTRK1_HUMAN 8J63A 3.001 Inactive DFGout None in-out out-in A6X Type2 500 - 796 None None 0
Homo sapiens NTRK1_HUMAN 5WR7A 2.76 Inactive DFGout None out-out out-in RCH Type2 489 - 792 None X677 2
Homo sapiens NTRK1_HUMAN 6PL1A 2.03 Inactive DFGout None in-out out-in OOJ Type2 500 - 795 None X677 3
Homo sapiens NTRK1_HUMAN 6PL3A 3.0 Inactive DFGout None in-out out-in OOD Type2 500 - 795 None None 0
Homo sapiens NTRK1_HUMAN 6PMAA 2.53 Inactive DFGout None in-in out-in OQS Type2 500 - 795 None X677 0
Homo sapiens NTRK1_HUMAN 6PMBA 2.81 Inactive DFGout None in-in out-in OQM Type2 500 - 795 None None 0
Homo sapiens NTRK1_HUMAN 6PMCA 2.19 Inactive DFGout None in-in out-in OQJ Type2 500 - 795 None X677 0
Homo sapiens NTRK1_HUMAN 6NSPA 2.31 Inactive DFGout None in-out out-in L0P Type3 500 - 795 None None 0
Homo sapiens NTRK1_HUMAN 6NPTA 2.19 Inactive DFGout None out-out out-in KWY Type3 491 - 795 None X677 0
Homo sapiens NTRK1_HUMAN 6NSSA 1.97 Inactive DFGout None in-out out-in L0M Type3 485 - 795 None None 0
Homo sapiens NTRK1_HUMAN 6D1YA 1.93 Inactive DFGout None out-out out-in FQJ Type3 481 - 796 None None 4
Homo sapiens NTRK1_HUMAN 5KMIA 1.87 Inactive DFGout None in-out out-in 6UE Type3 486 - 796 None None 0
Homo sapiens NTRK1_HUMAN 5KMJA 2.04 Inactive DFGout None in-in out-in 6UF Type3 486 - 795 None None 0
Homo sapiens NTRK1_HUMAN 5KMKA 2.24 Inactive DFGout None in-out out-in 6UG Type3 484 - 796 None None 0
Homo sapiens NTRK1_HUMAN 5KMMA 2.12 Inactive DFGout None in-out out-in 6UJ Type3 484 - 796 None None 0
Homo sapiens NTRK1_HUMAN 5KMLA 2.01 Inactive DFGout None in-out out-in 6UH Type3 474 - 796 None None 0
Homo sapiens NTRK1_HUMAN 5KMNA 2.14 Inactive DFGout None in-out out-in 6UK Type3 474 - 796 None None 0
Homo sapiens NTRK1_HUMAN 4YPSA 2.101 Inactive None None out-out out-in 4F6 Type1 502 - 790 None None 5
Homo sapiens NTRK1_HUMAN 6PMEA 3.0 Inactive None None in-out out-in OOY Type1 500 - 788 None X677 3
Homo sapiens NTRK1_HUMAN 6PMEC 3.0 Inactive None None in-out out-in OOY Type1 500 - 790 None X677 2

NTRK1 (High affinity nerve growth factor receptor)

No non-human structures known.