Protein kinases in complex with AN2

Total number of genes: 3
Total number of chains: 7
Spatial Dihedral Chains Representative
DFGin BLAminus 7 4YHJA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
AGC GRK4 GRK4_HUMAN G protein-coupled receptor kinase 4 4YHJA 2.6 Active DFGin BLAminus in-in in-in AN2 Type1
AGC GRK4 GRK4_HUMAN G protein-coupled receptor kinase 4 4YHJB 2.6 Active DFGin BLAminus in-in in-in AN2 Type1
CAMK DCLK1 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 5JZJA 1.71 Active DFGin BLAminus in-in in-in AN2 Type1
CAMK DCLK1 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 5JZJB 1.71 Active DFGin BLAminus in-in in-in AN2 Type1
CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8PSTA 1.9 Inactive DFGin BLAminus in-out in-out AN2 DC6 Type1 Allosteric
CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8PSWA 2.0 Inactive DFGin BLAminus in-out in-out AN2 D2I Type1 Allosteric
CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8PSYA 2.55 Inactive DFGin BLAminus in-out in-out AN2 EI0 Type1 Allosteric

Protein kinases in complex with AN2

Total number of genes: 6
Total number of chains: 11
Spatial Dihedral Chains Representative
DFGin BLAminus 8 5H9BA
DFGin None 3 4BWPA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Drosophila melanogaster CAMK CAMKII KCC2A_DROME Calcium/calmodulin-dependent protein kinase type II alpha chain 5H9BA 2.25 Active DFGin BLAminus in-in in-in AN2 Type1
Drosophila melanogaster OTHER PAN3 PAN3_DROME PAN2-PAN3 deadenylation complex subunit PAN3 4BWPA 3.6 Inactive DFGin None out-none out-none AN2 Type1
Drosophila melanogaster OTHER PAN3 PAN3_DROME PAN2-PAN3 deadenylation complex subunit PAN3 4BWPB 3.6 Inactive DFGin None out-none out-none AN2 Type1
Homo sapiens AGC GRK4 GRK4_HUMAN G protein-coupled receptor kinase 4 4YHJA 2.6 Active DFGin BLAminus in-in in-in AN2 Type1
Homo sapiens AGC GRK4 GRK4_HUMAN G protein-coupled receptor kinase 4 4YHJB 2.6 Active DFGin BLAminus in-in in-in AN2 Type1
Homo sapiens CAMK DCLK1 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 5JZJA 1.71 Active DFGin BLAminus in-in in-in AN2 Type1
Homo sapiens CAMK DCLK1 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 5JZJB 1.71 Active DFGin BLAminus in-in in-in AN2 Type1
Homo sapiens CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8PSTA 1.9 Inactive DFGin BLAminus in-out in-out AN2 DC6 Type1 Allosteric
Homo sapiens CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8PSWA 2.0 Inactive DFGin BLAminus in-out in-out AN2 D2I Type1 Allosteric
Homo sapiens CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8PSYA 2.55 Inactive DFGin BLAminus in-out in-out AN2 EI0 Type1 Allosteric
Tribolium castaneum OTHER PINK1 PINK1_TRICA Serine/threonine-protein kinase Pink1, mitochondrial 7MP9A 2.8 Inactive DFGin None in-in in-in AN2 Type1

Protein kinases in complex with AN2

Total number of genes: 3
Total number of chains: 4
Spatial Dihedral Chains Representative
DFGin BLAminus 1 5H9BA
DFGin None 3 4BWPA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Drosophila melanogaster CAMK CAMKII KCC2A_DROME Calcium/calmodulin-dependent protein kinase type II alpha chain 5H9BA 2.25 Active DFGin BLAminus in-in in-in AN2 Type1
Drosophila melanogaster OTHER PAN3 PAN3_DROME PAN2-PAN3 deadenylation complex subunit PAN3 4BWPA 3.6 Inactive DFGin None out-none out-none AN2 Type1
Drosophila melanogaster OTHER PAN3 PAN3_DROME PAN2-PAN3 deadenylation complex subunit PAN3 4BWPB 3.6 Inactive DFGin None out-none out-none AN2 Type1
Tribolium castaneum OTHER PINK1 PINK1_TRICA Serine/threonine-protein kinase Pink1, mitochondrial 7MP9A 2.8 Inactive DFGin None in-in in-in AN2 Type1