Ligand: SB4

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 1 100.0% 1BL7A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC MAPK14 MK14_HUMAN 1BL7A 2.5 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SB4 Type1 4 - 354 0 None None Mitogen-activated protein kinase 14

Ligand: SB4

Total number of chains: 26
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 17 65.4% 4LOOA
DFGin BLBminus 7 26.9% 4LOPB
DFGin BLAminus 1 3.8% 3ERKA
DFGin None 1 3.8% 6YCUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK14 MK14_HUMAN 1BL7A 2.5 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SB4 Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_MOUSE 4LOPB 2.049 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOPC 2.049 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 3 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOQA 2.319 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 3 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOQB 2.319 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 3 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOQC 2.319 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOQD 2.319 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y7ZA 1.35 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nooo OG2, SB4 Allosteric, Type1 5 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y80A 1.24 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaiii APEdist_nooo OFZ, SB4 Allosteric, Type1 5 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y85A 1.58 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnoo OG8, SB4 Allosteric, Type1 5 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y8HA 1.37 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4 Type1 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOOA 1.95 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo SB4 Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOPA 2.049 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo SB4 Type1 3 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOPD 2.049 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo SB4 Type1 3 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5O90A 2.49 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoni APEdist_nooo SB4 Type1 5 - 353 0 None T185G Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y7WA 1.39 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4, OFW Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y7XA 1.45 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4, OFQ Type1, Allosteric 5 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y81A 1.54 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4, OG5 Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y82A 1.44 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaioi APEdist_nooo SB4, 308 Type1, Allosteric 6 - 360 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6YCWA 1.34 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nooo SB4, OL8 Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SOVA 1.31 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4, LOT, LOW Type1, Allosteric, Allosteric 6 - 359 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SP9A 1.22 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno SB4, LOT, LOT Type1, Allosteric, Allosteric 5 - 359 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y7YA 1.51 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nnoo SB4, OFQ, LOT, LOT Type1, Allosteric, Allosteric, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SPLA 1.38 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaioi APEdist_nooo SB4, LOW, LOW, LOW Type1, Allosteric, Type1, Allosteric 6 - 359 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6YCUA 1.35 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno SB4, OKZ Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK1 MK01_RAT 3ERKA 2.1 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oiii SB4 Type1 6 - 355 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus

Ligand: SB4

Total number of chains: 25
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 17 68.0% 4LOOA
DFGin BLBminus 6 24.0% 4LOPB
DFGin BLAminus 1 4.0% 3ERKA
DFGin None 1 4.0% 6YCUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK14 MK14_MOUSE 4LOPB 2.049 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOPC 2.049 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 3 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOQA 2.319 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 3 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOQB 2.319 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 3 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOQC 2.319 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOQD 2.319 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo SB4 Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y7ZA 1.35 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nooo OG2, SB4 Allosteric, Type1 5 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y80A 1.24 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaiii APEdist_nooo OFZ, SB4 Allosteric, Type1 5 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y85A 1.58 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnoo OG8, SB4 Allosteric, Type1 5 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y8HA 1.37 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4 Type1 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOOA 1.95 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo SB4 Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOPA 2.049 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo SB4 Type1 3 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 4LOPD 2.049 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo SB4 Type1 3 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5O90A 2.49 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoni APEdist_nooo SB4 Type1 5 - 353 0 None T185G Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y7WA 1.39 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4, OFW Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y7XA 1.45 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4, OFQ Type1, Allosteric 5 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y81A 1.54 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4, OG5 Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y82A 1.44 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaioi APEdist_nooo SB4, 308 Type1, Allosteric 6 - 360 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6YCWA 1.34 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nooo SB4, OL8 Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SOVA 1.31 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo SB4, LOT, LOW Type1, Allosteric, Allosteric 6 - 359 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SP9A 1.22 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno SB4, LOT, LOT Type1, Allosteric, Allosteric 5 - 359 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6Y7YA 1.51 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaiii APEdist_nnoo SB4, OFQ, LOT, LOT Type1, Allosteric, Allosteric, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6SPLA 1.38 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaioi APEdist_nooo SB4, LOW, LOW, LOW Type1, Allosteric, Type1, Allosteric 6 - 359 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 6YCUA 1.35 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno SB4, OKZ Type1, Allosteric 6 - 359 0 None C162S Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK1 MK01_RAT 3ERKA 2.1 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oiii SB4 Type1 6 - 355 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus