Protein kinases in complex with HKI (Neratinib)

Total number of genes: 1
Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin BLAminus 1 3W2QA
DFGin BLBplus 1 2JIVB
DFGin None 1 2JIVA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 3W2QA 2.2 Inactive DFGin BLAminus out-out in-in HKI Type1.5_Front
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2JIVB 3.5 Inactive DFGin BLBplus out-out out-out HKI Type1.5_Back
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2JIVA 3.5 Inactive DFGin None out-out out-in HKI Type1.5_Back

Protein kinases in complex with HKI

Total number of genes: 1
Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin BLAminus 1 3W2QA
DFGin BLBplus 1 2JIVB
DFGin None 1 2JIVA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 3W2QA 2.2 Inactive DFGin BLAminus out-out in-in HKI Type1.5_Front
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2JIVB 3.5 Inactive DFGin BLBplus out-out out-out HKI Type1.5_Back
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2JIVA 3.5 Inactive DFGin None out-out out-in HKI Type1.5_Back

Protein kinases in complex with HKI

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type