Protein kinases in complex with 2HB (Filgotinib)

Total number of genes: 1
Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin ABAminus 2 4P7EB
DFGin None 1 5UT5A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 4P7EA 2.4 Inactive DFGin ABAminus in-in in-in 2HB Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 4P7EB 2.4 Inactive DFGin ABAminus in-in in-in 2HB Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 5UT5A 1.9 Inactive DFGin None in-none out-out 2HB Type1

Protein kinases in complex with 2HB

Total number of genes: 1
Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin ABAminus 2 4P7EB
DFGin None 1 5UT5A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 4P7EA 2.4 Inactive DFGin ABAminus in-in in-in 2HB Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 4P7EB 2.4 Inactive DFGin ABAminus in-in in-in 2HB Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 5UT5A 1.9 Inactive DFGin None in-none out-out 2HB Type1

Protein kinases in complex with 2HB

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type