CAMK_MKNK2 (MAP kinase-interacting serine/threonine-protein kinase 2)

Total number of chains: 17
Active chains: 2
Uniprot: MKNK2_HUMAN
Kinase Domain Residues: 83 - 368
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 10 58.8% 9HRCA
DFGin BLAminus 2 11.8% AF-Q9HBH9-K1A
DFGin None 2 11.8% 2AC5A
DFGin BLBminus 1 5.9% 8XFMA
DFGout BBAminus 1 5.9% 2AC3A
DFGout None 1 5.9% 6JLRA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9HBH9-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 75 - 376 0 None None MAP kinase-interacting serine/threonine-protein kinase 2
AF-Q9HBH9-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 75 - 376 0 None None MAP kinase-interacting serine/threonine-protein kinase 2
8XFMA 2.6 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo A1LU6 Type1 73 - 372 0 None None MAP kinase-interacting serine/threonine-protein kinase 2
2HW7A 2.71 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno STU Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
6CJ5A 2.8 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4G Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
6CJEA 3.36 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4A Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
6CJHA 3.6 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno ET8 Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
6CJWA 3.38 Inactive DFGin‑BLBplus out-in none-out nonTYR APEdihe_aaoii APEdist_nnno FYV Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
6CJYA 3.05 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4J Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
6CK3A 2.9 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F67 Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
6CK6A 3.32 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno N45 Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
6CKIA 2.95 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno FZJ Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
9HRCA 3.161 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo A1IWO Type1 72 - 375 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
2AC5A 3.2 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 72 - 370 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
8P9BA 2.59 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn X8K Type1 72 - 369 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
2AC3A 2.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 72 - 369 0 None None MAP kinase-interacting serine/threonine-protein kinase 2
6JLRA 2.901 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnno BV9 Type1 72 - 369 0 None None MAP kinase-interacting serine/threonine-protein kinase 2

CAMK_MKNK2 (MAP kinase-interacting serine/threonine-protein kinase 2)

Total number of chains: 17
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 10 58.8% 9HRCA
DFGin BLAminus 2 11.8% AF-Q9HBH9-K1A
DFGin None 2 11.8% 2AC5A
DFGin BLBminus 1 5.9% 8XFMA
DFGout BBAminus 1 5.9% 2AC3A
DFGout None 1 5.9% 6JLRA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MKNK2_HUMAN AF-Q9HBH9-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 75 - 376 0 None None MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN AF-Q9HBH9-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 75 - 376 0 None None MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 8XFMA 2.6 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo A1LU6 Type1 73 - 372 0 None None MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 2HW7A 2.71 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno STU Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6CJ5A 2.8 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4G Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6CJEA 3.36 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4A Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6CJHA 3.6 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno ET8 Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6CJWA 3.38 Inactive DFGin‑BLBplus out-in none-out nonTYR APEdihe_aaoii APEdist_nnno FYV Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6CJYA 3.05 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4J Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6CK3A 2.9 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F67 Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6CK6A 3.32 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno N45 Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6CKIA 2.95 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno FZJ Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 9HRCA 3.161 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo A1IWO Type1 72 - 375 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 2AC5A 3.2 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 72 - 370 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 8P9BA 2.59 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn X8K Type1 72 - 369 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 2AC3A 2.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 72 - 369 0 None None MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
MKNK2_HUMAN 6JLRA 2.901 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnno BV9 Type1 72 - 369 0 None None MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens

CAMK_MKNK2 (MAP kinase-interacting serine/threonine-protein kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism