Ligand: 38O (Dovitinib)

Total number of chains: 14
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 1 7AKGA
DFGin BLAplus 7 5A46B
DFGin None 4 7QQ6B
None None 2 5OWQB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CAMK STK17B ST17B_HUMAN 7AKG 2.08 Inactive DFGin‑BLAminus in-in in-out 38O Type1 25 - 309 0 None None Serine/threonine-protein kinase 17B
OTHER EIF2AK4 E2AK4_HUMAN 7QQ6 2.8 Inactive DFGin‑None out-out none-out 38O Type1 584 - 1004 20 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4 E2AK4_HUMAN 7QQ6 2.8 Inactive DFGin‑None out-out none-out 38O Type1 584 - 1006 18 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4 E2AK4_HUMAN 7QQ6 2.8 Inactive DFGin‑None out-out out-out 38O Type1 584 - 1006 29 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4 E2AK4_HUMAN 7QQ6 2.8 Inactive DFGin‑None out-out out-none 38O Type1 584 - 1006 29 None D848N eIF-2-alpha kinase GCN2
STE STK10 STK10_HUMAN 5OWQ 2.7 Inactive None‑None out-none none-none 38O Type1 30 - 317 20 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5OWQ 2.7 Inactive None‑None out-out none-none 38O Type1 32 - 317 20 None None Serine/threonine-protein kinase 10
TYR FGFR1 FGFR1_HUMAN 5AM7 1.957 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 764 0 None V561M Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM7 1.957 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 762 5 None V561M Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM6 1.96 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 765 0 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM6 1.96 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 762 13 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5A46 2.63 Inactive DFGin‑BLAplus in-in out-out 38O Type1 464 - 766 3 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5A46 2.63 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 766 0 None None Fibroblast growth factor receptor 1
TYR FGFR4 FGFR4_HUMAN 4TYI 3.4 Inactive DFGin‑BLAplus in-out out-out 38O Type1 447 - 750 14 None None Fibroblast growth factor receptor 4

Ligand: 38O (Dovitinib)

Total number of chains: 14
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 1 7AKGA
DFGin BLAplus 7 5A46B
DFGin None 4 7QQ6B
None None 2 5OWQB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CAMK STK17B ST17B_HUMAN 7AKG 2.08 Inactive DFGin‑BLAminus in-in in-out 38O Type1 25 - 309 0 None None Serine/threonine-protein kinase 17B Homo sapiens
OTHER EIF2AK4 E2AK4_HUMAN 7QQ6 2.8 Inactive DFGin‑None out-out none-out 38O Type1 584 - 1004 20 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4 E2AK4_HUMAN 7QQ6 2.8 Inactive DFGin‑None out-out none-out 38O Type1 584 - 1006 18 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4 E2AK4_HUMAN 7QQ6 2.8 Inactive DFGin‑None out-out out-out 38O Type1 584 - 1006 29 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4 E2AK4_HUMAN 7QQ6 2.8 Inactive DFGin‑None out-out out-none 38O Type1 584 - 1006 29 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
STE STK10 STK10_HUMAN 5OWQ 2.7 Inactive None‑None out-none none-none 38O Type1 30 - 317 20 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 5OWQ 2.7 Inactive None‑None out-out none-none 38O Type1 32 - 317 20 None None Serine/threonine-protein kinase 10 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 5AM7 1.957 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 764 0 None V561M Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 5AM7 1.957 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 762 5 None V561M Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 5AM6 1.96 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 765 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 5AM6 1.96 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 762 13 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 5A46 2.63 Inactive DFGin‑BLAplus in-in out-out 38O Type1 464 - 766 3 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 5A46 2.63 Inactive DFGin‑BLAplus in-in out-out 38O Type1 458 - 766 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 4TYI 3.4 Inactive DFGin‑BLAplus in-out out-out 38O Type1 447 - 750 14 None None Fibroblast growth factor receptor 4 Homo sapiens

Ligand: 38O (Dovitinib)

Total number of chains: 0
Spatial label Dihedral label Number of Chains Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism