Ligand

Protein kinases in complex with SKE

Total number of genes: 4

Total number of chains: 13

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	6	4QMUA
DFGin	ABAminus	3	5DT0A
DFGin	None	3	8B99A
None	None	1	5OBRA

Database table as tsv

Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
AGC	PRKACA	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit alpha	3AMAA	1.75	Active	DFGin	BLAminus	in-in	in-in	SKE	Type1
CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5DPVA	2.285	Inactive	DFGin	ABAminus	out-in	in-out	5DN SKE	Allosteric Type1
CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5DR6A	2.534	Inactive	DFGin	ABAminus	out-in	in-out	5E1 SKE	Allosteric Type1
CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5DT0A	2.15	Inactive	DFGin	ABAminus	in-in	in-out	SKE	Type1
CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5DR9A	2.47	Inactive	DFGin	BLAminus	out-out	out-out	SKE 5E2	Type1 Allosteric
CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5OBRA	2.62	Inactive	None	None	out-out	out-out	9QT SKE	Allosteric Type1
STE	STK24	STK24_HUMAN	Serine/threonine-protein kinase 24	4QMUA	1.546	Active	DFGin	BLAminus	in-in	in-in	SKE	Type1
TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	5USYA	2.0	Active	DFGin	BLAminus	in-in	in-in	SKE	Type1
TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	5USYB	2.0	Active	DFGin	BLAminus	in-in	in-in	SKE	Type1
TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	6DRWA	2.303	Inactive	DFGin	BLAminus	in-out	in-in	SKE	Type1
TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	8B99A	1.6	Inactive	DFGin	None	out-none	out-out	SKE	Type1
TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	5WINA	2.38	Inactive	DFGin	None	out-none	out-out	SKE	Type1
TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	5USZA	2.103	Inactive	DFGin	None	in-none	out-out	SKE	Type1

Protein kinases in complex with SKE

Total number of genes: 4

Total number of chains: 13

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	6	4QMUA
DFGin	ABAminus	3	5DT0A
DFGin	None	3	8B99A
None	None	1	5OBRA

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
Homo sapiens	AGC	PRKACA	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit alpha	3AMAA	1.75	Active	DFGin	BLAminus	in-in	in-in	SKE	Type1
Homo sapiens	CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5DPVA	2.285	Inactive	DFGin	ABAminus	out-in	in-out	5DN SKE	Allosteric Type1
Homo sapiens	CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5DR6A	2.534	Inactive	DFGin	ABAminus	out-in	in-out	5E1 SKE	Allosteric Type1
Homo sapiens	CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5DT0A	2.15	Inactive	DFGin	ABAminus	in-in	in-out	SKE	Type1
Homo sapiens	CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5DR9A	2.47	Inactive	DFGin	BLAminus	out-out	out-out	SKE 5E2	Type1 Allosteric
Homo sapiens	CAMK	AURKA	AURKA_HUMAN	Aurora kinase A	5OBRA	2.62	Inactive	None	None	out-out	out-out	9QT SKE	Allosteric Type1
Homo sapiens	STE	STK24	STK24_HUMAN	Serine/threonine-protein kinase 24	4QMUA	1.546	Active	DFGin	BLAminus	in-in	in-in	SKE	Type1
Homo sapiens	TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	5USYA	2.0	Active	DFGin	BLAminus	in-in	in-in	SKE	Type1
Homo sapiens	TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	5USYB	2.0	Active	DFGin	BLAminus	in-in	in-in	SKE	Type1
Homo sapiens	TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	6DRWA	2.303	Inactive	DFGin	BLAminus	in-out	in-in	SKE	Type1
Homo sapiens	TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	8B99A	1.6	Inactive	DFGin	None	out-none	out-out	SKE	Type1
Homo sapiens	TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	5WINA	2.38	Inactive	DFGin	None	out-none	out-out	SKE	Type1
Homo sapiens	TYR	JAK2	JAK2_HUMAN	Tyrosine-protein kinase JAK2	5USZA	2.103	Inactive	DFGin	None	in-none	out-out	SKE	Type1

Protein kinases in complex with SKE

Total number of genes: 0

Total number of chains: 0

Spatial	Dihedral	Chains	Representative

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type