STE_MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

Total number of chains: 42
Active chains: 5
Uniprot: MP2K7_HUMAN
Kinase Domain Residues: 120 - 380
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 15 35.7% 5Y90A
DFGin BLAminus 10 23.8% AF-O14733-K1A
DFGin None 7 16.7% 7OVNA
DFGin ABAminus 5 11.9% 6QFLA
DFGout BBAminus 2 4.8% 6YG7B
DFGin BLAplus 1 2.4% 7OVIA
DFGin BLBplus 1 2.4% 7OVJA
None None 1 2.4% 6YG2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-O14733-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 112 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 7
AF-O14733-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 112 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6YG1A 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 86 - 404 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
6YG1B 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 93 - 404 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
6YG1C 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 86 - 405 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
6QFLA 2.2 Inactive DFGin‑ABAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6QFTA 2.7 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aanai APEdist_nnnn J0B Type1 102 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6QG4A 2.3 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn J0E Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6QG7A 2.1 Inactive DFGin‑ABAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 6HL Type1 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6QHOA 2.7 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn J3H Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6IB0A 2.6 Inactive DFGin‑BLAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi H8Z Type1 101 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6QHRA 2.52 Inactive DFGin‑BLAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi J3N Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
7OVIA 1.95 Inactive DFGin‑BLAplus in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2GI Type1.5_Front 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
7OVJA 2.35 Inactive DFGin‑BLBplus in-na none-none nonTYR APEdihe_aaiai APEdist_nnni 24N Type1.5_Front 102 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7
5B2MA 3.06 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 105 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
7OVLA 2.9 Inactive DFGin‑None in-na none-out nonTYR APEdihe_aaiai APEdist_nnoi 1XZ Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
7OVMA 2.9 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni 21I Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
7OVNA 2.9 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 2I8 Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
9HZ0A 2.25 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni A1IY7 Type1 101 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
7OVKA 2.05 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2I5 Type1.5_Back 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6IB2A 2.1 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 862 Type1.5_Front 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6YG7A 2.2 Inactive DFGout‑BBAminus out-na none-out nonTYR APEdihe_aanao APEdist_nnnn OQ2 Type2 102 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
6YG7B 2.2 Inactive DFGout‑BBAminus out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ2 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
6YZ4A 1.7 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno 1E8 Allosteric 101 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7
5Y8UA 2.92 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnoo No_ligand No_ligand 103 - 402 0 None C260S Dual specificity mitogen-activated protein kinase kinase 7
5Y90A 1.3 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 103 - 419 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
5B2LA 2.1 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni No_ligand No_ligand 104 - 403 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
6YFZA 1.9 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 100 - 405 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6QFRA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
5B2KA 2.75 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 104 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6YG0A 2.0 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
7CBXA 2.061 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn FU6 Type1 103 - 402 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
5Z1EA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 419 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6YG4A 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn SU9 Type1 103 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6YG5A 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn IHH Type1 101 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7
3WZUA 3.01 Inactive DFGout‑None none-na none-out nonTYR APEdihe_aaoai APEdist_nnno 1FM Type1 104 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6YG6A 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
6YG6B 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 104 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
6YG2A 2.0 Inactive None‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn 1E8, 8E8 Allosteric, Type1.5_Front 102 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7
2DYLA 2.45 None DFGin‑BLAminus in-na none-none nonTYR APEdihe_aanai APEdist_nnnn No_ligand No_ligand 103 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
5Z1DA 2.28 None DFGin‑BLAminus in-na none-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7
6YG3A 2.05 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn 6HF Type1 103 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7

STE_MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

Total number of chains: 42
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 15 35.7% 5Y90A
DFGin BLAminus 10 23.8% AF-O14733-K1A
DFGin None 7 16.7% 7OVNA
DFGin ABAminus 5 11.9% 6QFLA
DFGout BBAminus 2 4.8% 6YG7B
DFGin BLAplus 1 2.4% 7OVIA
DFGin BLBplus 1 2.4% 7OVJA
None None 1 2.4% 6YG2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MP2K7_HUMAN AF-O14733-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 112 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN AF-O14733-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 112 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG1A 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 86 - 404 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG1B 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 93 - 404 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG1C 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 86 - 405 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6QFLA 2.2 Inactive DFGin‑ABAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6QFTA 2.7 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aanai APEdist_nnnn J0B Type1 102 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6QG4A 2.3 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn J0E Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6QG7A 2.1 Inactive DFGin‑ABAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 6HL Type1 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6QHOA 2.7 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn J3H Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6IB0A 2.6 Inactive DFGin‑BLAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi H8Z Type1 101 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6QHRA 2.52 Inactive DFGin‑BLAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi J3N Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 7OVIA 1.95 Inactive DFGin‑BLAplus in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2GI Type1.5_Front 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 7OVJA 2.35 Inactive DFGin‑BLBplus in-na none-none nonTYR APEdihe_aaiai APEdist_nnni 24N Type1.5_Front 102 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 5B2MA 3.06 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 105 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 7OVLA 2.9 Inactive DFGin‑None in-na none-out nonTYR APEdihe_aaiai APEdist_nnoi 1XZ Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 7OVMA 2.9 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni 21I Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 7OVNA 2.9 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 2I8 Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 9HZ0A 2.25 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni A1IY7 Type1 101 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 7OVKA 2.05 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2I5 Type1.5_Back 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6IB2A 2.1 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 862 Type1.5_Front 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG7A 2.2 Inactive DFGout‑BBAminus out-na none-out nonTYR APEdihe_aanao APEdist_nnnn OQ2 Type2 102 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG7B 2.2 Inactive DFGout‑BBAminus out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ2 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YZ4A 1.7 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno 1E8 Allosteric 101 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 5Y8UA 2.92 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnoo No_ligand No_ligand 103 - 402 0 None C260S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 5Y90A 1.3 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 103 - 419 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 5B2LA 2.1 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni No_ligand No_ligand 104 - 403 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YFZA 1.9 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 100 - 405 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6QFRA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 5B2KA 2.75 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 104 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG0A 2.0 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 7CBXA 2.061 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn FU6 Type1 103 - 402 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 5Z1EA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 419 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG4A 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn SU9 Type1 103 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG5A 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn IHH Type1 101 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 3WZUA 3.01 Inactive DFGout‑None none-na none-out nonTYR APEdihe_aaoai APEdist_nnno 1FM Type1 104 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG6A 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG6B 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 104 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG2A 2.0 Inactive None‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn 1E8, 8E8 Allosteric, Type1.5_Front 102 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 2DYLA 2.45 None DFGin‑BLAminus in-na none-none nonTYR APEdihe_aanai APEdist_nnnn No_ligand No_ligand 103 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 5Z1DA 2.28 None DFGin‑BLAminus in-na none-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
MP2K7_HUMAN 6YG3A 2.05 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn 6HF Type1 103 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens

STE_MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism