MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

Group: STE
Uniprot: MP2K7_HUMAN
Domain boundary: 120 - 380


Total number of chains: 40
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-O14733-K1A
DFGin BLAplus 1 7OVIA
DFGin ABAminus 5 6QFLA
DFGin BLBplus 1 7OVJA
DFGin None 6 7OVNA
DFGout BBAminus 2 6YG7B
DFGout None 15 5Y90A
None None 1 6YG2A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
6QFLA 2.2 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 102 - 402 None None 9
6QFTA 2.7 Inactive DFGin ABAminus in-in in-none J0B Type1 102 - 400 None None 12
6QG4A 2.3 Inactive DFGin ABAminus in-in in-none J0E Type1 111 - 401 None None 13
6QG7A 2.1 Inactive DFGin ABAminus in-out in-in 6HL Type1 102 - 401 None None 9
6QHOA 2.7 Inactive DFGin ABAminus in-in in-none J3H Type1 111 - 401 None None 15
AF-O14733-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 112 - 388 None None 0
2DYLA 2.45 None DFGin BLAminus in-in none-none No_ligand No_ligand 103 - 402 S271D,T275D None 14
6YG1A 2.22 Active DFGin BLAminus in-in in-in No_ligand No_ligand 86 - 404 S271D,T275D None 0
6YG1B 2.22 Active DFGin BLAminus in-in in-in No_ligand No_ligand 93 - 404 S271D,T275D None 0
6YG1C 2.22 Active DFGin BLAminus in-in in-in No_ligand No_ligand 86 - 405 S271D,T275D None 0
5Z1DA 2.28 None DFGin BLAminus in-in none-in 95U Type1 103 - 403 None None 13
6YG3A 2.05 None DFGin BLAminus in-in in-none 6HF Type1 103 - 400 None None 19
6IB0A 2.6 Active DFGin BLAminus in-in in-in H8Z Type1 101 - 400 None None 10
6QHRA 2.52 Active DFGin BLAminus in-in in-in J3N Type1 111 - 401 None None 9
7OVIA 1.95 Inactive DFGin BLAplus in-out none-none 2GI Type1.5_Front 102 - 402 None None 23
7OVJA 2.35 Inactive DFGin BLBplus in-out none-in 24N Type1.5_Front 102 - 403 None None 15
5B2MA 3.06 Inactive DFGin None out-out none-out No_ligand No_ligand 105 - 400 None None 15
7OVLA 2.9 Inactive DFGin None in-none none-in 1XZ Type1 102 - 402 None None 12
7OVMA 2.9 Inactive DFGin None in-in in-in 21I Type1 102 - 402 None None 11
7OVNA 2.9 Inactive DFGin None in-in in-in 2I8 Type1 102 - 402 None None 10
7OVKA 2.05 Inactive DFGin None in-out none-none 2I5 Type1.5_Back 102 - 401 None None 25
6IB2A 2.1 Inactive DFGin None in-out none-none 862 Type1.5_Front 102 - 401 None None 19
6YG7A 2.2 Inactive DFGout BBAminus out-out none-none OQ2 Type2 102 - 403 S271D,T275D None 15
6YG7B 2.2 Inactive DFGout BBAminus out-out none-out OQ2 Type2 103 - 403 S271D,T275D None 13
6YZ4A 1.7 Inactive DFGout None in-out out-out 1E8 Allosteric 101 - 404 None None 10
5Y8UA 2.92 Inactive DFGout None out-out none-out No_ligand No_ligand 103 - 402 C260S None 13
5Y90A 1.3 Inactive DFGout None in-out out-in No_ligand No_ligand 103 - 419 C202S None 11
5B2LA 2.1 Inactive DFGout None in-out out-in No_ligand No_ligand 104 - 403 C202S None 12
6YFZA 1.9 Inactive DFGout None in-out out-out No_ligand No_ligand 100 - 405 None None 11
6QFRA 2.3 Inactive DFGout None in-none out-none No_ligand No_ligand 102 - 402 None None 15
5B2KA 2.75 Inactive DFGout None out-out none-out No_ligand No_ligand 104 - 400 None None 15
6YG0A 2.0 Inactive DFGout None in-in out-none No_ligand No_ligand 102 - 402 S271D,T275D None 14
7CBXA 2.061 Inactive DFGout None in-out out-none FU6 Type1 103 - 402 C202S None 12
5Z1EA 2.3 Inactive DFGout None in-out out-in 95U Type1 103 - 419 None None 12
6YG4A 2.3 Inactive DFGout None in-out out-none SU9 Type1 103 - 401 None None 21
6YG5A 2.4 Inactive DFGout None in-none out-none IHH Type1 101 - 403 None None 21
3WZUA 3.01 Inactive DFGout None none-none none-out 1FM Type1 104 - 402 None None 14
6YG6A 2.15 Inactive DFGout None out-out none-out OQ8 Type2 103 - 403 S271D,T275D None 14
6YG6B 2.15 Inactive DFGout None out-out none-out OQ8 Type2 104 - 403 S271D,T275D None 15
6YG2A 2.0 Inactive None None in-out out-none 1E8 8E8 Allosteric Type1.5_Front 102 - 404 None None 13

MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

Group: STE
Total number of chains: 40
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-O14733-K1A
DFGin BLAplus 1 7OVIA
DFGin ABAminus 5 6QFLA
DFGin BLBplus 1 7OVJA
DFGin None 6 7OVNA
DFGout BBAminus 2 6YG7B
DFGout None 15 5Y90A
None None 1 6YG2A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MP2K7_HUMAN 6QFLA 2.2 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 102 - 402 None None 9
Homo sapiens MP2K7_HUMAN 6QFTA 2.7 Inactive DFGin ABAminus in-in in-none J0B Type1 102 - 400 None None 12
Homo sapiens MP2K7_HUMAN 6QG4A 2.3 Inactive DFGin ABAminus in-in in-none J0E Type1 111 - 401 None None 13
Homo sapiens MP2K7_HUMAN 6QG7A 2.1 Inactive DFGin ABAminus in-out in-in 6HL Type1 102 - 401 None None 9
Homo sapiens MP2K7_HUMAN 6QHOA 2.7 Inactive DFGin ABAminus in-in in-none J3H Type1 111 - 401 None None 15
Homo sapiens MP2K7_HUMAN AF-O14733-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 112 - 388 None None 0
Homo sapiens MP2K7_HUMAN 2DYLA 2.45 None DFGin BLAminus in-in none-none No_ligand No_ligand 103 - 402 S271D,T275D None 14
Homo sapiens MP2K7_HUMAN 6YG1A 2.22 Active DFGin BLAminus in-in in-in No_ligand No_ligand 86 - 404 S271D,T275D None 0
Homo sapiens MP2K7_HUMAN 6YG1B 2.22 Active DFGin BLAminus in-in in-in No_ligand No_ligand 93 - 404 S271D,T275D None 0
Homo sapiens MP2K7_HUMAN 6YG1C 2.22 Active DFGin BLAminus in-in in-in No_ligand No_ligand 86 - 405 S271D,T275D None 0
Homo sapiens MP2K7_HUMAN 5Z1DA 2.28 None DFGin BLAminus in-in none-in 95U Type1 103 - 403 None None 13
Homo sapiens MP2K7_HUMAN 6YG3A 2.05 None DFGin BLAminus in-in in-none 6HF Type1 103 - 400 None None 19
Homo sapiens MP2K7_HUMAN 6IB0A 2.6 Active DFGin BLAminus in-in in-in H8Z Type1 101 - 400 None None 10
Homo sapiens MP2K7_HUMAN 6QHRA 2.52 Active DFGin BLAminus in-in in-in J3N Type1 111 - 401 None None 9
Homo sapiens MP2K7_HUMAN 7OVIA 1.95 Inactive DFGin BLAplus in-out none-none 2GI Type1.5_Front 102 - 402 None None 23
Homo sapiens MP2K7_HUMAN 7OVJA 2.35 Inactive DFGin BLBplus in-out none-in 24N Type1.5_Front 102 - 403 None None 15
Homo sapiens MP2K7_HUMAN 5B2MA 3.06 Inactive DFGin None out-out none-out No_ligand No_ligand 105 - 400 None None 15
Homo sapiens MP2K7_HUMAN 7OVLA 2.9 Inactive DFGin None in-none none-in 1XZ Type1 102 - 402 None None 12
Homo sapiens MP2K7_HUMAN 7OVMA 2.9 Inactive DFGin None in-in in-in 21I Type1 102 - 402 None None 11
Homo sapiens MP2K7_HUMAN 7OVNA 2.9 Inactive DFGin None in-in in-in 2I8 Type1 102 - 402 None None 10
Homo sapiens MP2K7_HUMAN 7OVKA 2.05 Inactive DFGin None in-out none-none 2I5 Type1.5_Back 102 - 401 None None 25
Homo sapiens MP2K7_HUMAN 6IB2A 2.1 Inactive DFGin None in-out none-none 862 Type1.5_Front 102 - 401 None None 19
Homo sapiens MP2K7_HUMAN 6YG7A 2.2 Inactive DFGout BBAminus out-out none-none OQ2 Type2 102 - 403 S271D,T275D None 15
Homo sapiens MP2K7_HUMAN 6YG7B 2.2 Inactive DFGout BBAminus out-out none-out OQ2 Type2 103 - 403 S271D,T275D None 13
Homo sapiens MP2K7_HUMAN 6YZ4A 1.7 Inactive DFGout None in-out out-out 1E8 Allosteric 101 - 404 None None 10
Homo sapiens MP2K7_HUMAN 5Y8UA 2.92 Inactive DFGout None out-out none-out No_ligand No_ligand 103 - 402 C260S None 13
Homo sapiens MP2K7_HUMAN 5Y90A 1.3 Inactive DFGout None in-out out-in No_ligand No_ligand 103 - 419 C202S None 11
Homo sapiens MP2K7_HUMAN 5B2LA 2.1 Inactive DFGout None in-out out-in No_ligand No_ligand 104 - 403 C202S None 12
Homo sapiens MP2K7_HUMAN 6YFZA 1.9 Inactive DFGout None in-out out-out No_ligand No_ligand 100 - 405 None None 11
Homo sapiens MP2K7_HUMAN 6QFRA 2.3 Inactive DFGout None in-none out-none No_ligand No_ligand 102 - 402 None None 15
Homo sapiens MP2K7_HUMAN 5B2KA 2.75 Inactive DFGout None out-out none-out No_ligand No_ligand 104 - 400 None None 15
Homo sapiens MP2K7_HUMAN 6YG0A 2.0 Inactive DFGout None in-in out-none No_ligand No_ligand 102 - 402 S271D,T275D None 14
Homo sapiens MP2K7_HUMAN 7CBXA 2.061 Inactive DFGout None in-out out-none FU6 Type1 103 - 402 C202S None 12
Homo sapiens MP2K7_HUMAN 5Z1EA 2.3 Inactive DFGout None in-out out-in 95U Type1 103 - 419 None None 12
Homo sapiens MP2K7_HUMAN 6YG4A 2.3 Inactive DFGout None in-out out-none SU9 Type1 103 - 401 None None 21
Homo sapiens MP2K7_HUMAN 6YG5A 2.4 Inactive DFGout None in-none out-none IHH Type1 101 - 403 None None 21
Homo sapiens MP2K7_HUMAN 3WZUA 3.01 Inactive DFGout None none-none none-out 1FM Type1 104 - 402 None None 14
Homo sapiens MP2K7_HUMAN 6YG6A 2.15 Inactive DFGout None out-out none-out OQ8 Type2 103 - 403 S271D,T275D None 14
Homo sapiens MP2K7_HUMAN 6YG6B 2.15 Inactive DFGout None out-out none-out OQ8 Type2 104 - 403 S271D,T275D None 15
Homo sapiens MP2K7_HUMAN 6YG2A 2.0 Inactive None None in-out out-none 1E8 8E8 Allosteric Type1.5_Front 102 - 404 None None 13

MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

No non-human structures known.