RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Group: TKL
Uniprot: RIPK3_HUMAN
Domain boundary: 21 - 285


Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 5 AF-Q9Y572-K1A
DFGin BLBplus 3 9LFUB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q9Y572-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 293 None None 0
7MX3B 3.23 None DFGin BLAminus in-out in-none ZOV Type1 12 - 309 C3S,C110A None 16
7MX3A 3.23 None DFGin BLAminus in-in in-none ZOV Type1.5_Back 12 - 314 C3S,C110A None 10
7MX3C 3.23 None DFGin BLAminus in-in in-none ZOV Type1.5_Back 9 - 311 C3S,C110A None 10
7MX3D 3.23 None DFGin BLAminus in-in in-none ZOV Type1.5_Back 12 - 311 C3S,C110A None 14
9LFUA 2.93 Inactive DFGin BLBplus out-out out-none A1D97 Type1.5_Back 5 - 308 C3S,C110A None 12
9LFUB 2.93 Inactive DFGin BLBplus out-out out-none A1D97 Type1.5_Back 5 - 309 C3S,C110A None 14
7MONB 2.23 Inactive DFGin BLBplus out-out none-out ZL1 Type1.5_Front 5 - 311 C3S,C110A X224,X227 12

RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Group: TKL
Total number of chains: 38
Spatial Dihedral Chains Representative
DFGin BLAminus 23 AF-Q9Y572-K1A
DFGin BLBplus 5 4M69A
DFGin None 5 9LFVA
DFGout None 5 6OKOA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens RIPK3_HUMAN AF-Q9Y572-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 293 None None 0
Homo sapiens RIPK3_HUMAN 7MX3B 3.23 None DFGin BLAminus in-out in-none ZOV Type1 12 - 309 C3S,C110A None 16
Homo sapiens RIPK3_HUMAN 7MX3A 3.23 None DFGin BLAminus in-in in-none ZOV Type1.5_Back 12 - 314 C3S,C110A None 10
Homo sapiens RIPK3_HUMAN 7MX3C 3.23 None DFGin BLAminus in-in in-none ZOV Type1.5_Back 9 - 311 C3S,C110A None 10
Homo sapiens RIPK3_HUMAN 7MX3D 3.23 None DFGin BLAminus in-in in-none ZOV Type1.5_Back 12 - 311 C3S,C110A None 14
Homo sapiens RIPK3_HUMAN 9LFUA 2.93 Inactive DFGin BLBplus out-out out-none A1D97 Type1.5_Back 5 - 308 C3S,C110A None 12
Homo sapiens RIPK3_HUMAN 9LFUB 2.93 Inactive DFGin BLBplus out-out out-none A1D97 Type1.5_Back 5 - 309 C3S,C110A None 14
Homo sapiens RIPK3_HUMAN 7MONB 2.23 Inactive DFGin BLBplus out-out none-out ZL1 Type1.5_Front 5 - 311 C3S,C110A X224,X227 12
Mus musculus RIPK3_MOUSE 4M66A 2.401 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 15 - 312 C111A None 15
Mus musculus RIPK3_MOUSE 4M66B 2.401 None DFGin BLAminus in-in in-none No_ligand No_ligand 14 - 313 C111A None 19
Mus musculus RIPK3_MOUSE 9IX2B 2.39 None DFGin BLAminus in-in in-none No_ligand No_ligand 13 - 313 None None 19
Mus musculus RIPK3_MOUSE 9IWYA 2.52 None DFGin BLAminus none-none none-none A1D97 Type1 15 - 311 None None 25
Mus musculus RIPK3_MOUSE 9IX0A 2.1 Active DFGin BLAminus in-in in-in A1D99 Type1 15 - 312 None None 17
Mus musculus RIPK3_MOUSE 9IX0B 2.1 None DFGin BLAminus in-in in-none A1D99 Type1 13 - 311 None None 19
Mus musculus RIPK3_MOUSE 9IX1A 2.31 None DFGin BLAminus in-in in-none PP2 Type1 15 - 313 None None 19
Mus musculus RIPK3_MOUSE 9IX1B 2.31 None DFGin BLAminus in-in in-none PP2 Type1 15 - 313 None None 18
Mus musculus RIPK3_MOUSE 9LVGA 2.03 None DFGin BLAminus in-in in-none LKR Type1 14 - 312 None None 18
Mus musculus RIPK3_MOUSE 9LVGB 2.03 None DFGin BLAminus in-in in-none LKR Type1 14 - 311 None None 19
Mus musculus RIPK3_MOUSE 9LVHA 2.38 None DFGin BLAminus in-in in-none MYF Type1 13 - 312 None None 19
Mus musculus RIPK3_MOUSE 9LVHB 2.38 None DFGin BLAminus in-in in-none MYF Type1 13 - 312 None None 18
Mus musculus RIPK3_MOUSE 9IWWA 1.93 Active DFGin BLAminus in-in in-in A1D96 Type1.5_Back 13 - 312 None None 16
Mus musculus RIPK3_MOUSE 9IWWB 1.93 Inactive DFGin BLAminus in-in in-out A1D96 Type1.5_Back 13 - 313 None None 14
Mus musculus RIPK3_MOUSE 9IWZA 1.82 Active DFGin BLAminus in-in in-in ZOV Type1.5_Back 13 - 312 None None 15
Mus musculus RIPK3_MOUSE 9IWZB 1.82 Inactive DFGin BLAminus in-in in-out ZOV Type1.5_Back 14 - 313 None None 16
Mus musculus RIPK3_MOUSE 9IWXA 1.99 None DFGin BLAminus in-in in-none A1D96 Type1.5_Back 14 - 311 R69H None 18
Mus musculus RIPK3_MOUSE 9IWXB 1.99 Inactive DFGin BLAminus in-in in-out A1D96 Type1.5_Back 14 - 313 R69H None 16
Mus musculus RIPK3_MOUSE 4M69A 2.497 Inactive DFGin BLBplus out-out out-out ANP Type1 12 - 312 None X184,X231,X232 14
Mus musculus RIPK3_MOUSE 9LFWA 1.59 Inactive DFGin BLBplus out-out out-none A1D97 Type1.5_Back 5 - 312 R69H None 18
Mus musculus RIPK3_MOUSE 9IWYB 2.52 Inactive DFGin None in-none none-none A1D97 Type1 15 - 311 None None 23
Mus musculus RIPK3_MOUSE 9LFVB 2.78 Inactive DFGin None out-out out-none A1EJP Type1 14 - 311 None None 20
Mus musculus RIPK3_MOUSE 9LFVC 2.78 Inactive DFGin None out-none out-none A1EJP Type1 14 - 311 None None 21
Mus musculus RIPK3_MOUSE 9LFVD 2.78 Inactive DFGin None out-none out-none A1EJP Type1 13 - 311 None None 20
Mus musculus RIPK3_MOUSE 9LFVA 2.78 Inactive DFGin None out-none out-out A1EJO A1EJP Type1 Type1 13 - 311 None None 18
Mus musculus RIPK3_MOUSE 6OKOA 2.1 Inactive DFGout None in-in none-out 1FN Type2 14 - 311 None None 23
Mus musculus RIPK3_MOUSE 6OKOB 2.1 Inactive DFGout None in-out none-none 1FN Type2 13 - 311 None None 25
Mus musculus RIPK3_MOUSE 9IX2A 2.39 Inactive DFGout None in-none none-none 1SU Type2 15 - 311 None None 24
Mus musculus RIPK3_MOUSE 9IX3A 2.07 Inactive DFGout None in-in none-none A1EAA Type2 15 - 311 None None 24
Mus musculus RIPK3_MOUSE 9IX3B 2.07 Inactive DFGout None in-in none-none A1EAA Type2 15 - 310 None None 25

RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Group: TKL
Total number of chains: 30
Spatial Dihedral Chains Representative
DFGin BLAminus 18 9IWZA
DFGin BLBplus 2 4M69A
DFGin None 5 9LFVA
DFGout None 5 6OKOA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus RIPK3_MOUSE 4M66A 2.401 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 15 - 312 C111A None 15
Mus musculus RIPK3_MOUSE 4M66B 2.401 None DFGin BLAminus in-in in-none No_ligand No_ligand 14 - 313 C111A None 19
Mus musculus RIPK3_MOUSE 9IX2B 2.39 None DFGin BLAminus in-in in-none No_ligand No_ligand 13 - 313 None None 19
Mus musculus RIPK3_MOUSE 9IWYA 2.52 None DFGin BLAminus none-none none-none A1D97 Type1 15 - 311 None None 25
Mus musculus RIPK3_MOUSE 9IX0A 2.1 Active DFGin BLAminus in-in in-in A1D99 Type1 15 - 312 None None 17
Mus musculus RIPK3_MOUSE 9IX0B 2.1 None DFGin BLAminus in-in in-none A1D99 Type1 13 - 311 None None 19
Mus musculus RIPK3_MOUSE 9IX1A 2.31 None DFGin BLAminus in-in in-none PP2 Type1 15 - 313 None None 19
Mus musculus RIPK3_MOUSE 9IX1B 2.31 None DFGin BLAminus in-in in-none PP2 Type1 15 - 313 None None 18
Mus musculus RIPK3_MOUSE 9LVGA 2.03 None DFGin BLAminus in-in in-none LKR Type1 14 - 312 None None 18
Mus musculus RIPK3_MOUSE 9LVGB 2.03 None DFGin BLAminus in-in in-none LKR Type1 14 - 311 None None 19
Mus musculus RIPK3_MOUSE 9LVHA 2.38 None DFGin BLAminus in-in in-none MYF Type1 13 - 312 None None 19
Mus musculus RIPK3_MOUSE 9LVHB 2.38 None DFGin BLAminus in-in in-none MYF Type1 13 - 312 None None 18
Mus musculus RIPK3_MOUSE 9IWWA 1.93 Active DFGin BLAminus in-in in-in A1D96 Type1.5_Back 13 - 312 None None 16
Mus musculus RIPK3_MOUSE 9IWWB 1.93 Inactive DFGin BLAminus in-in in-out A1D96 Type1.5_Back 13 - 313 None None 14
Mus musculus RIPK3_MOUSE 9IWZA 1.82 Active DFGin BLAminus in-in in-in ZOV Type1.5_Back 13 - 312 None None 15
Mus musculus RIPK3_MOUSE 9IWZB 1.82 Inactive DFGin BLAminus in-in in-out ZOV Type1.5_Back 14 - 313 None None 16
Mus musculus RIPK3_MOUSE 9IWXA 1.99 None DFGin BLAminus in-in in-none A1D96 Type1.5_Back 14 - 311 R69H None 18
Mus musculus RIPK3_MOUSE 9IWXB 1.99 Inactive DFGin BLAminus in-in in-out A1D96 Type1.5_Back 14 - 313 R69H None 16
Mus musculus RIPK3_MOUSE 4M69A 2.497 Inactive DFGin BLBplus out-out out-out ANP Type1 12 - 312 None X184,X231,X232 14
Mus musculus RIPK3_MOUSE 9LFWA 1.59 Inactive DFGin BLBplus out-out out-none A1D97 Type1.5_Back 5 - 312 R69H None 18
Mus musculus RIPK3_MOUSE 9IWYB 2.52 Inactive DFGin None in-none none-none A1D97 Type1 15 - 311 None None 23
Mus musculus RIPK3_MOUSE 9LFVB 2.78 Inactive DFGin None out-out out-none A1EJP Type1 14 - 311 None None 20
Mus musculus RIPK3_MOUSE 9LFVC 2.78 Inactive DFGin None out-none out-none A1EJP Type1 14 - 311 None None 21
Mus musculus RIPK3_MOUSE 9LFVD 2.78 Inactive DFGin None out-none out-none A1EJP Type1 13 - 311 None None 20
Mus musculus RIPK3_MOUSE 9LFVA 2.78 Inactive DFGin None out-none out-out A1EJO A1EJP Type1 Type1 13 - 311 None None 18
Mus musculus RIPK3_MOUSE 6OKOA 2.1 Inactive DFGout None in-in none-out 1FN Type2 14 - 311 None None 23
Mus musculus RIPK3_MOUSE 6OKOB 2.1 Inactive DFGout None in-out none-none 1FN Type2 13 - 311 None None 25
Mus musculus RIPK3_MOUSE 9IX2A 2.39 Inactive DFGout None in-none none-none 1SU Type2 15 - 311 None None 24
Mus musculus RIPK3_MOUSE 9IX3A 2.07 Inactive DFGout None in-in none-none A1EAA Type2 15 - 311 None None 24
Mus musculus RIPK3_MOUSE 9IX3B 2.07 Inactive DFGout None in-in none-none A1EAA Type2 15 - 310 None None 25