TKL_RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Total number of chains: 9
Active chains: 2
Uniprot: RIPK3_HUMAN
Kinase Domain Residues: 21 - 285
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 66.7% AF-Q9Y572-K1A
DFGin BLBplus 3 33.3% 9LFUB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9Y572-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 293 0 None None Receptor-interacting serine/threonine-protein kinase 3
AF-Q9Y572-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 293 0 None None Receptor-interacting serine/threonine-protein kinase 3
7MX3B 3.23 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ZOV Type1 12 - 309 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3
9LFUA 2.93 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aanii APEdist_nnnn A1D97 Type1.5_Back 5 - 308 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3
9LFUB 2.93 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1D97 Type1.5_Back 5 - 309 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3
7MONB 2.23 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaoii APEdist_oooo ZL1 Type1.5_Front 5 - 311 0 TPO224,SEP227 C3S,C110A Receptor-interacting serine/threonine-protein kinase 3
7MX3A 3.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ZOV Type1.5_Back 12 - 314 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3
7MX3C 3.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ZOV Type1.5_Back 9 - 311 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3
7MX3D 3.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ZOV Type1.5_Back 12 - 311 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3

TKL_RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Total number of chains: 39
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 24 61.5% AF-Q9Y572-K1A
DFGin BLBplus 5 12.8% 4M69A
DFGin None 5 12.8% 9LFVA
DFGout None 5 12.8% 6OKOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
RIPK3_HUMAN AF-Q9Y572-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 293 0 None None Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_HUMAN AF-Q9Y572-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 293 0 None None Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_HUMAN 7MX3B 3.23 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ZOV Type1 12 - 309 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_HUMAN 9LFUA 2.93 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aanii APEdist_nnnn A1D97 Type1.5_Back 5 - 308 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_HUMAN 9LFUB 2.93 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1D97 Type1.5_Back 5 - 309 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_HUMAN 7MONB 2.23 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaoii APEdist_oooo ZL1 Type1.5_Front 5 - 311 0 TPO224,SEP227 C3S,C110A Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_HUMAN 7MX3A 3.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ZOV Type1.5_Back 12 - 314 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_HUMAN 7MX3C 3.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ZOV Type1.5_Back 9 - 311 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_HUMAN 7MX3D 3.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ZOV Type1.5_Back 12 - 311 0 None C3S,C110A Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
RIPK3_MOUSE 4M66A 2.401 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 15 - 312 0 None C111A Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX1B 2.31 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn PP2 Type1 15 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWWB 1.93 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo A1D96 Type1.5_Back 13 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWZB 1.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ZOV Type1.5_Back 14 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWXB 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo A1D96 Type1.5_Back 14 - 313 0 None R69H Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 4M69A 2.497 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 12 - 312 0 SEP184,TPO231,SEP232 None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFWA 1.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1D97 Type1.5_Back 5 - 312 0 None R69H Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWYB 2.52 Inactive DFGin‑None in-none none-none nonTYR APEdihe_aannn APEdist_nnnn A1D97 Type1 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFVB 2.78 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn A1EJP Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFVC 2.78 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aannn APEdist_nnnn A1EJP Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFVD 2.78 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aanni APEdist_nnnn A1EJP Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFVA 2.78 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnno A1EJO, A1EJP Type1, Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 6OKOA 2.1 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 1FN Type2 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 6OKOB 2.1 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn 1FN Type2 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX2A 2.39 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoi APEdist_nnnn 1SU Type2 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX3A 2.07 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn A1EAA Type2 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX3B 2.07 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn A1EAA Type2 15 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 4M66B 2.401 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 14 - 313 0 None C111A Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX2B 2.39 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 13 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWYA 2.52 None DFGin‑BLAminus none-none none-none nonTYR APEdihe_aannn APEdist_nnnn A1D97 Type1 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX0A 2.1 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni A1D99 Type1 15 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX0B 2.1 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn A1D99 Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX1A 2.31 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn PP2 Type1 15 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LVGA 2.03 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn LKR Type1 14 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LVGB 2.03 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn LKR Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LVHA 2.38 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn MYF Type1 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LVHB 2.38 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn MYF Type1 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWWA 1.93 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii A1D96 Type1.5_Back 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWZA 1.82 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii ZOV Type1.5_Back 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWXA 1.99 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn A1D96 Type1.5_Back 14 - 311 0 None R69H Receptor-interacting serine/threonine-protein kinase 3 Mus musculus

TKL_RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Total number of chains: 30
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 18 60.0% 9IWZA
DFGin None 5 16.7% 9LFVA
DFGout None 5 16.7% 6OKOA
DFGin BLBplus 2 6.7% 4M69A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
RIPK3_MOUSE 4M66A 2.401 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 15 - 312 0 None C111A Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX1B 2.31 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn PP2 Type1 15 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWWB 1.93 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo A1D96 Type1.5_Back 13 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWZB 1.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ZOV Type1.5_Back 14 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWXB 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo A1D96 Type1.5_Back 14 - 313 0 None R69H Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 4M69A 2.497 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 12 - 312 0 SEP184,TPO231,SEP232 None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFWA 1.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1D97 Type1.5_Back 5 - 312 0 None R69H Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWYB 2.52 Inactive DFGin‑None in-none none-none nonTYR APEdihe_aannn APEdist_nnnn A1D97 Type1 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFVB 2.78 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn A1EJP Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFVC 2.78 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aannn APEdist_nnnn A1EJP Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFVD 2.78 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aanni APEdist_nnnn A1EJP Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LFVA 2.78 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnno A1EJO, A1EJP Type1, Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 6OKOA 2.1 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 1FN Type2 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 6OKOB 2.1 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn 1FN Type2 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX2A 2.39 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoi APEdist_nnnn 1SU Type2 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX3A 2.07 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn A1EAA Type2 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX3B 2.07 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn A1EAA Type2 15 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 4M66B 2.401 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 14 - 313 0 None C111A Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX2B 2.39 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 13 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWYA 2.52 None DFGin‑BLAminus none-none none-none nonTYR APEdihe_aannn APEdist_nnnn A1D97 Type1 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX0A 2.1 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni A1D99 Type1 15 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX0B 2.1 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn A1D99 Type1 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IX1A 2.31 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn PP2 Type1 15 - 313 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LVGA 2.03 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn LKR Type1 14 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LVGB 2.03 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn LKR Type1 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LVHA 2.38 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn MYF Type1 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9LVHB 2.38 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn MYF Type1 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWWA 1.93 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii A1D96 Type1.5_Back 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWZA 1.82 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii ZOV Type1.5_Back 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
RIPK3_MOUSE 9IWXA 1.99 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn A1D96 Type1.5_Back 14 - 311 0 None R69H Receptor-interacting serine/threonine-protein kinase 3 Mus musculus