CMGC_CLK1 (Dual specificity protein kinase CLK1)

Total number of chains: 61
Active chains: 39
Uniprot: CLK1_HUMAN
Kinase Domain Residues: 161 - 477
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 59 96.7% AF-P49759-K3A
DFGin ABAminus 1 1.6% 6KHDC
DFGin None 1 1.6% 6KHDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P49759-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 153 - 484 0 None None Dual specificity protein kinase CLK1
6YTDA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 148 - 484 0 None V324A Dual specificity protein kinase CLK1
6QTYA 1.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V25 Type1 149 - 481 0 None None Dual specificity protein kinase CLK1
6R3DA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JQW Type1 152 - 481 0 None None Dual specificity protein kinase CLK1
6R6EA 2.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JTQ Type1 153 - 481 0 None None Dual specificity protein kinase CLK1
6R6XA 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JU8 Type1 152 - 481 0 None None Dual specificity protein kinase CLK1
7O9YA 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V5T Type1 152 - 481 0 None None Dual specificity protein kinase CLK1
7OA0AAA 1.81 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JTQ Type1 152 - 481 0 None None Dual specificity protein kinase CLK1
1Z57A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DBQ Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
5J1VA 2.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6FD Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
5J1VB 2.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6FD Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
5J1WA 2.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6FB Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
5J1WB 2.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6FB Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6FT8A 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E6T Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
6FT9A 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E6W Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6FT9B 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E6W Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6I5HA 1.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3N Type1 148 - 481 0 None None Dual specificity protein kinase CLK1
6I5IA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3E Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
6I5KB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3H Type1 148 - 481 0 None None Dual specificity protein kinase CLK1
6I5KC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3H Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
6I5LB 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3Q Type1 148 - 481 0 None None Dual specificity protein kinase CLK1
6I5LC 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3Q Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
6Q8KA 2.29 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FG9 Type1 148 - 484 0 None None Dual specificity protein kinase CLK1
6YTAA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii IYZ Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
6YTEC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 148 - 484 0 None None Dual specificity protein kinase CLK1
6YTIA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 7A7 Type1 150 - 482 0 None None Dual specificity protein kinase CLK1
6Z4ZA 2.07 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6Z4ZB 2.07 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 148 - 484 0 None None Dual specificity protein kinase CLK1
6Z4ZC 2.07 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6ZLNA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PKB Type1 148 - 484 0 None None Dual specificity protein kinase CLK1
7AK3A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RH8 Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
7OPGA 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 06N Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
7OPGB 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 06N Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
7OPGC 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 06N Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6FYOA 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAQ Type1 148 - 481 0 None None Dual specificity protein kinase CLK1
5X8IA 1.902 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SQZ Type1 154 - 481 0 None R432A Dual specificity protein kinase CLK1
5X8IB 1.902 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SQZ Type1 155 - 481 0 None R432A Dual specificity protein kinase CLK1
6YTGA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KHC, KHC Type1, Allosteric 148 - 483 0 None None Dual specificity protein kinase CLK1
6R8JA 1.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JUW, JUW Type1, Type1 152 - 481 0 None None Dual specificity protein kinase CLK1
6KHDC 2.7 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 3NG Type1 150 - 479 0 None None Dual specificity protein kinase CLK1
AF-P49759-K1A -1.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii No_ligand No_ligand 153 - 484 0 None None Dual specificity protein kinase CLK1
2VAGA 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaino APEdist_oioo V25 Type1 148 - 481 0 SEP341,TPO342 None Dual specificity protein kinase CLK1
5J1VC 2.52 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aannn APEdist_oion 6FD Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
6FT9C 1.87 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oioo E6W Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6G33A 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaino APEdist_oioo 5ID Type1 148 - 482 0 SEP341,TPO342 None Dual specificity protein kinase CLK1
6G33B 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_iioo 5ID Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6G33C 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaini APEdist_oioi 5ID Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6I5KA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oioo H3H Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6I5LA 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oioo H3Q Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
6Q8PB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aannn APEdist_oion HQB Type1 148 - 483 0 None None Dual specificity protein kinase CLK1
6RAAA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii JWN Type1 148 - 481 0 None None Dual specificity protein kinase CLK1
6TW2E 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanao APEdist_oioo V25 Type1 148 - 484 0 SEP341,TPO342 None Dual specificity protein kinase CLK1
6Z50A 1.6 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Q7K Type1 149 - 481 0 None None Dual specificity protein kinase CLK1
8P04A 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaono APEdist_nnni WAK Type1 148 - 481 0 None None Dual specificity protein kinase CLK1
8P08A 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_iioo WAZ Type1 148 - 481 0 None None Dual specificity protein kinase CLK1
8UWNA 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaino APEdist_oioo XQX Type1 148 - 482 0 SEP341,TPO342 None Dual specificity protein kinase CLK1
6KHDB 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_iiii 3NG Type1 149 - 482 0 None None Dual specificity protein kinase CLK1
5J1WC 2.42 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oioo 6FB, 6FB Type1, Allosteric 148 - 483 0 None None Dual specificity protein kinase CLK1
6KHDA 2.7 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aannn APEdist_ioon 3NG Type1 149 - 481 0 None None Dual specificity protein kinase CLK1
6Q8PA 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_iiin HQB Type1 148 - 482 0 None None Dual specificity protein kinase CLK1
6Q8PC 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_iiin HQB Type1 148 - 483 0 None None Dual specificity protein kinase CLK1

CMGC_CLK1 (Dual specificity protein kinase CLK1)

Total number of chains: 77
Active chains: 45
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 75 97.4% AF-P49759-K3A
DFGin ABAminus 1 1.3% 6KHDC
DFGin None 1 1.3% 6KHDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CLK1_HUMAN AF-P49759-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 153 - 484 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6YTDA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 148 - 484 0 None V324A Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6QTYA 1.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V25 Type1 149 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6R3DA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JQW Type1 152 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6R6EA 2.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JTQ Type1 153 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6R6XA 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JU8 Type1 152 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 7O9YA 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V5T Type1 152 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 7OA0AAA 1.81 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JTQ Type1 152 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 1Z57A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DBQ Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 5J1VA 2.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6FD Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 5J1VB 2.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6FD Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 5J1WA 2.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6FB Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 5J1WB 2.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6FB Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6FT8A 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E6T Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6FT9A 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E6W Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6FT9B 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E6W Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6I5HA 1.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3N Type1 148 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6I5IA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3E Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6I5KB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3H Type1 148 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6I5KC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3H Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6I5LB 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3Q Type1 148 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6I5LC 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H3Q Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6Q8KA 2.29 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FG9 Type1 148 - 484 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6YTAA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii IYZ Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6YTEC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 148 - 484 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6YTIA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 7A7 Type1 150 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6Z4ZA 2.07 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6Z4ZB 2.07 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 148 - 484 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6Z4ZC 2.07 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6ZLNA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PKB Type1 148 - 484 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 7AK3A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RH8 Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 7OPGA 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 06N Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 7OPGB 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 06N Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 7OPGC 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 06N Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6FYOA 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAQ Type1 148 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 5X8IA 1.902 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SQZ Type1 154 - 481 0 None R432A Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 5X8IB 1.902 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SQZ Type1 155 - 481 0 None R432A Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6YTGA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KHC, KHC Type1, Allosteric 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6R8JA 1.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JUW, JUW Type1, Type1 152 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6KHDC 2.7 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 3NG Type1 150 - 479 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN AF-P49759-K1A -1.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii No_ligand No_ligand 153 - 484 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 2VAGA 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaino APEdist_oioo V25 Type1 148 - 481 0 SEP341,TPO342 None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 5J1VC 2.52 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aannn APEdist_oion 6FD Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6FT9C 1.87 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oioo E6W Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6G33A 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaino APEdist_oioo 5ID Type1 148 - 482 0 SEP341,TPO342 None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6G33B 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_iioo 5ID Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6G33C 2.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaini APEdist_oioi 5ID Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6I5KA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oioo H3H Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6I5LA 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oioo H3Q Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6Q8PB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aannn APEdist_oion HQB Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6RAAA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii JWN Type1 148 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6TW2E 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanao APEdist_oioo V25 Type1 148 - 484 0 SEP341,TPO342 None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6Z50A 1.6 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Q7K Type1 149 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 8P04A 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaono APEdist_nnni WAK Type1 148 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 8P08A 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_iioo WAZ Type1 148 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 8UWNA 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaino APEdist_oioo XQX Type1 148 - 482 0 SEP341,TPO342 None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6KHDB 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_iiii 3NG Type1 149 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 5J1WC 2.42 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oioo 6FB, 6FB Type1, Allosteric 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6KHDA 2.7 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aannn APEdist_ioon 3NG Type1 149 - 481 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6Q8PA 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_iiin HQB Type1 148 - 482 0 None None Dual specificity protein kinase CLK1 Homo sapiens
CLK1_HUMAN 6Q8PC 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_iiin HQB Type1 148 - 483 0 None None Dual specificity protein kinase CLK1 Homo sapiens
Q382U0_TRYB2 6Q2AD 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AE 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AG 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AM 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AN 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AP 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AC 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AF 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AH 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AI 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AJ 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AK 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AL 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AO 2.6 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei

CMGC_CLK1 (Dual specificity protein kinase CLK1)

Total number of chains: 16
Active chains: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 100.0% 6Q2AD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
Q382U0_TRYB2 6Q2AD 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AE 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AG 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AM 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AN 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AP 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AC 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AF 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AH 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AI 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AJ 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AK 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AL 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
Q382U0_TRYB2 6Q2AO 2.6 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei