ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Group: TYR

Uniprot: ROS1_HUMAN

Domain boundary: 1945 - 2217

Total number of chains: 8

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	1	AF-P08922-K1A
DFGin	ABAminus	2	4UXLA
DFGin	None	5	7Z5WA

Database table as tsv

PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
3ZBFA	2.2	Inactive	DFGin	ABAminus	in-in	in-out	VGH	Type1	1934 - 2230	None	None	12
4UXLA	2.4	Inactive	DFGin	ABAminus	in-out	in-out	5P8	Type1	1934 - 2230	None	None	8
AF-P08922-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	1937 - 2225	None	None	0
7Z5WA	2.254	Inactive	DFGin	None	in-out	none-out	IDW	Type1	1937 - 2225	None	None	18
7Z5WB	2.254	Inactive	DFGin	None	in-out	none-out	IDW	Type1	1937 - 2226	None	None	18
7Z5XA	2.035	Inactive	DFGin	None	in-in	none-out	AWJ	Type1	1937 - 2225	None	None	19
7Z5XB	2.035	Inactive	DFGin	None	in-in	none-out	AWJ	Type1	1937 - 2226	None	None	19
9QEKA	2.205	Inactive	DFGin	None	in-out	none-out	A1I6Z	Type1	1934 - 2229	G2032R	None	18

ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Group: TYR

Total number of chains: 8

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	1	AF-P08922-K1A
DFGin	ABAminus	2	4UXLA
DFGin	None	5	7Z5WA

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Homo sapiens	ROS1_HUMAN	3ZBFA	2.2	Inactive	DFGin	ABAminus	in-in	in-out	VGH	Type1	1934 - 2230	None	None	12
Homo sapiens	ROS1_HUMAN	4UXLA	2.4	Inactive	DFGin	ABAminus	in-out	in-out	5P8	Type1	1934 - 2230	None	None	8
Homo sapiens	ROS1_HUMAN	AF-P08922-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	1937 - 2225	None	None	0
Homo sapiens	ROS1_HUMAN	7Z5WA	2.254	Inactive	DFGin	None	in-out	none-out	IDW	Type1	1937 - 2225	None	None	18
Homo sapiens	ROS1_HUMAN	7Z5WB	2.254	Inactive	DFGin	None	in-out	none-out	IDW	Type1	1937 - 2226	None	None	18
Homo sapiens	ROS1_HUMAN	7Z5XA	2.035	Inactive	DFGin	None	in-in	none-out	AWJ	Type1	1937 - 2225	None	None	19
Homo sapiens	ROS1_HUMAN	7Z5XB	2.035	Inactive	DFGin	None	in-in	none-out	AWJ	Type1	1937 - 2226	None	None	19
Homo sapiens	ROS1_HUMAN	9QEKA	2.205	Inactive	DFGin	None	in-out	none-out	A1I6Z	Type1	1934 - 2229	G2032R	None	18

ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

No non-human structures known.