TYR_ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Total number of chains: 9
Active chains: 2
Uniprot: ROS1_HUMAN
Kinase Domain Residues: 1945 - 2217
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 5 55.6% 7Z5WA
DFGin ABAminus 2 22.2% 4UXLA
DFGin BLAminus 2 22.2% AF-P08922-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P08922-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS
AF-P08922-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS
3ZBFA 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_nniai APEdist_aaao VGH Type1 1934 - 2230 0 None None Proto-oncogene tyrosine-protein kinase ROS
4UXLA 2.4 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_ooiai APEdist_aaao 5P8 Type1 1934 - 2230 0 None None Proto-oncogene tyrosine-protein kinase ROS
7Z5WA 2.254 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao IDW Type1 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS
7Z5WB 2.254 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao IDW Type1 1937 - 2226 0 None None Proto-oncogene tyrosine-protein kinase ROS
7Z5XA 2.035 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao AWJ Type1 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS
7Z5XB 2.035 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao AWJ Type1 1937 - 2226 0 None None Proto-oncogene tyrosine-protein kinase ROS
9QEKA 2.205 Inactive DFGin‑None in-out none-out TYR APEdihe_niiai APEdist_aaao A1I6Z Type1 1934 - 2229 0 None G2032R Proto-oncogene tyrosine-protein kinase ROS

TYR_ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Total number of chains: 9
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 5 55.6% 7Z5WA
DFGin ABAminus 2 22.2% 4UXLA
DFGin BLAminus 2 22.2% AF-P08922-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ROS1_HUMAN AF-P08922-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
ROS1_HUMAN AF-P08922-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
ROS1_HUMAN 3ZBFA 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_nniai APEdist_aaao VGH Type1 1934 - 2230 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
ROS1_HUMAN 4UXLA 2.4 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_ooiai APEdist_aaao 5P8 Type1 1934 - 2230 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
ROS1_HUMAN 7Z5WA 2.254 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao IDW Type1 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
ROS1_HUMAN 7Z5WB 2.254 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao IDW Type1 1937 - 2226 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
ROS1_HUMAN 7Z5XA 2.035 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao AWJ Type1 1937 - 2225 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
ROS1_HUMAN 7Z5XB 2.035 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao AWJ Type1 1937 - 2226 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens
ROS1_HUMAN 9QEKA 2.205 Inactive DFGin‑None in-out none-out TYR APEdihe_niiai APEdist_aaao A1I6Z Type1 1934 - 2229 0 None G2032R Proto-oncogene tyrosine-protein kinase ROS Homo sapiens

TYR_ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism