TKL_IRAK4 (Interleukin-1 receptor-associated kinase 4)

Total number of chains: 284
Active chains: 87
Uniprot: IRAK4_HUMAN
Kinase Domain Residues: 175 - 456
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 271 95.4% AF-Q9NWZ3-K1A
DFGout None 4 1.4% 6EG9A
DFGin None 3 1.1% 8TVMD
DFGin BLBminus 2 0.7% 2NRYA
None None 2 0.7% 8TVND
DFGin BLAplus 1 0.4% 9R9KC
DFGin BLBtrans 1 0.4% 6EGFB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
2OIDD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
AF-Q9NWZ3-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 167 - 460 0 None None Interleukin-1 receptor-associated kinase 4
AF-Q9NWZ3-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 167 - 460 0 None None Interleukin-1 receptor-associated kinase 4
2OIBA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OIBC 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6F3GA 2.37 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii CJN Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6F3GB 2.37 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii CJN Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6N8GA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6N8GC 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6N8GD 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7C2VA 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FJ0 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7C2VB 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FJ0 Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7C2VC 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FJ0 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7C2VD 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FJ0 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OICA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OICB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OICD 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4XS2B 2.73 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 42P Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4YO6B 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4GD Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4YP8A 2.641 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTLA 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTLB 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTLC 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTMA 2.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S2 Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTMB 2.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S2 Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTMD 2.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S2 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTNB 2.23 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S3 Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K72A 2.22 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QY Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K72C 2.22 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QY Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K72D 2.22 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QY Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K75A 2.03 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QX Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K76B 2.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6R1 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K7GA 2.23 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6R0 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K7GC 2.23 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6R0 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K7GD 2.23 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6R0 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K7IA 2.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QZ Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K7IB 2.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QZ Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5KX7B 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6YD Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5KX8A 2.671 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6YE Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5KX8B 2.671 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6YE Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5KX8D 2.671 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6YE Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5T1SD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 76Q Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4Y73D 2.14 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XPY Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6MOMA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JX4 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6MOMC 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JX4 Type1 163 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA3A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWX Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA3H0A0 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWX Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA4A 2.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW1 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA4B 2.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW1 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA4C 2.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW1 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA4D 2.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5W84A 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 9YY Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCEB 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVD Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCED 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVD Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCEE 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVD Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCVA 2.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVG Type1 163 - 458 0 SEP284,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCWA 2.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVA Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCWB 2.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVA Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCWC 2.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVA Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCWD 2.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVA Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2NRYC 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4
2NRYD 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 460 0 TPO345 None Interleukin-1 receptor-associated kinase 4
8TVMB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii VDC Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8TVNA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii VE9 Type1 167 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6THXA 1.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii N9Z Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6THZA 2.38 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NB5 Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6TI8A 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NBW Type1 165 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6TI8B 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NBW Type1 165 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6TI8C 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NBW Type1 164 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6TI8D 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NBW Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG3A 2.11 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B4U Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9JA 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDR Type1 161 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9JB 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDR Type1 161 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9JC 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDR Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9JD 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDR Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9KA 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDQ Type1 162 - 460 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9KB 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDQ Type1 158 - 460 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O9DC 2.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LTY Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6UYAC 1.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QL7 Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8W3WA 1.976 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFO Type1 162 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8W3WB 1.976 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFO Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8W3WC 1.976 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFO Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8W3WD 1.976 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFO Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8ATLAAA 2.464 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii O6X Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8ATLBBB 2.464 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii O6X Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
6EGEA 1.401 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DL1 Type1 165 - 459 0 None None Interleukin-1 receptor-associated kinase 4
5T1SB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 76Q Type1.5_Back 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OIDA 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OIDB 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OIDC 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 166 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7C2WA 3.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YTH, FJ9 Allosteric, Type1 164 - 458 0 SEP346 None Interleukin-1 receptor-associated kinase 4
7C2WB 3.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YTH, FJ9 Allosteric, Type1 163 - 458 0 SEP346 None Interleukin-1 receptor-associated kinase 4
7C2WC 3.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YTH, FJ9 Allosteric, Type1 164 - 458 0 SEP346 None Interleukin-1 receptor-associated kinase 4
7C2WD 3.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YTH, FJ9 Allosteric, Type1 164 - 458 0 SEP346 None Interleukin-1 receptor-associated kinase 4
2O8YA 2.4 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 165 - 459 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4
2O8YB 2.4 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 165 - 459 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4
2OIBB 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OIBD 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6F3DA 2.38 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CJT Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6F3DB 2.38 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CJT Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6F3EA 2.67 Inactive DFGin‑BLAminus in-out none-in nonTYR APEdihe_aaiii APEdist_iiii CJQ Type1 164 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4
6F3EB 2.67 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CJQ Type1 164 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4
6N8GB 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8BR5AAA 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R73 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8BR5BBB 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R73 Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8BR5CCC 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R73 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8BR5DDD 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R73 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4XS2A 2.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 42P Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4XS2C 2.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 42P Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4XS2D 2.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 42P Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4YO6A 2.32 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GD Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4YO6C 2.32 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GD Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4YP8B 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4YP8C 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4YP8D 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTLD 2.39 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTMC 2.66 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S2 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTNA 2.23 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S3 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTNC 2.23 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S3 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4ZTND 2.23 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S3 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K75B 2.03 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6QX Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K75C 2.03 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6QX Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K75D 2.03 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6QX Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K76A 2.74 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6R1 Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5KX8C 2.671 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6YE Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5T1SA 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76Q Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5T1SC 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76Q Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5T1TA 2.34 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76P Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5T1TB 2.34 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76P Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5T1TC 2.34 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76P Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5T1TD 2.34 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76P Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4Y73A 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XPY Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4Y73B 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XPY Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4Y73C 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XPY Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6MOMB 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii JX4 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6MOMD 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii JX4 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA2A 1.99 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW0 Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA2B 1.99 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW0 Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA5A 1.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWY Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA5B 1.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWY Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA5C 1.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWY Type1 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA5D 1.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWY Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA6A 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWZ Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA6B 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWZ Type1 166 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA6C 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWZ Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9NA6D 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWZ Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O8UA 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LS7 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O8UB 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LS7 Type1 160 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O8UC 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LS7 Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O8UD 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LS7 Type1 162 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5W85A 2.25 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 9YS Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5W85B 2.25 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 9YS Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6LXYA 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6LXYD 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 162 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6LXYE 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6VQLA 2.069 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R7S Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6VQLB 2.069 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R7S Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6VQLC 2.069 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R7S Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6VQLD 2.069 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R7S Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCEA 1.89 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ZVD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8SCVB 2.69 Inactive DFGin‑BLAminus in-none none-out nonTYR APEdihe_aannn APEdist_ooon ZVG Type1 165 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2NRUA 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T12 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2NRUB 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T12 Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2NRUC 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T12 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2NRUD 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T12 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4RMZA 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T20 Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4RMZB 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T20 Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8TVMA 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VDC Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8TVNB 1.95 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VE9 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8TVNC 1.95 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VE9 Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8TX0A 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VEU Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8TX0B 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VEU Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8UCBA 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii X1T Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8UCBB 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii X1T Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8UCBC 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii X1T Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8UCBD 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii X1T Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8UCCA 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii WFQ Type1 160 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8UCCB 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii WFQ Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4
6THWA 2.44 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii NBK Type1 164 - 458 0 None None Interleukin-1 receptor-associated kinase 4
6THWB 2.44 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii NBK Type1 164 - 458 0 None None Interleukin-1 receptor-associated kinase 4
6THXB 1.99 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii N9Z Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6THZB 2.38 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii NB5 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG2A 3.031 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B6I Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG2B 3.031 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B6I Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG2C 3.031 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B6I Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG2D 3.031 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B6I Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG3B 2.11 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B4U Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG5A 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B7R Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG5B 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B7R Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9GA 1.88 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9GB 1.88 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9GC 1.88 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9GD 1.88 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9KD 1.87 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDQ Type1 164 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O94A 1.98 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LRS Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O94B 1.98 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LRS Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O94C 1.98 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LRS Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O94D 1.98 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LRS Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O95A 1.77 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LSV Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O95B 1.77 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LSV Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O95C 1.77 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LSV Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O95D 1.77 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LSV Type1 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O9DA 2.51 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LTY Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O9DB 2.51 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LTY Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6O9DD 2.51 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LTY Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6UYAA 1.74 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii QL7 Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6UYAB 1.74 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii QL7 Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6UYAD 1.74 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii QL7 Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6F3IA 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CKN Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6F3IB 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CKN Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6RFIA 2.31 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii K1H Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6RFIB 2.31 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii K1H Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6RFJA 2.61 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii K1E Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6RFJB 2.61 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii K1E Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG1A 2.07 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B8I Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
7QG1B 2.07 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B8I Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UIQA 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BV Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UIQB 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BV Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UIQC 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BV Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UIQD 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BV Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UIRA 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BY Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UIRB 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BY Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UISA 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8C1 Type1 165 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4
5UISB 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8C1 Type1 165 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4
5UISC 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8C1 Type1 162 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4
5UISD 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8C1 Type1 165 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4
5UITA 1.84 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CD Type1 162 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UITB 1.84 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CD Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UIUA 2.02 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CG Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5UIUB 2.02 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CG Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8W3XA 1.765 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFH Type1 162 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8W3XB 1.765 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFH Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8W3XC 1.765 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFH Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8W3XD 1.765 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFH Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V1OA 2.92 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V1OB 2.92 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V1OC 2.92 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V1OD 2.92 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V2FA 2.09 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJU Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V2FB 2.09 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJU Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V2FC 2.09 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJU Type1 160 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V2FD 2.09 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJU Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V2LA 2.43 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK0 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V2LB 2.43 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK0 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V2LC 2.43 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK0 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8V2LD 2.43 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK0 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8ATBAAA 2.35 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii O0H Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8ATBBBB 2.35 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii O0H Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8ATNAAA 2.171 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii O06 Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8ATNBBB 2.171 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii O06 Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8BR6AAA 2.167 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R6I Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8BR6BBB 2.167 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R6I Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8BR7AAA 2.119 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R6R Type1 165 - 458 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8BR7BBB 2.119 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R6R Type1 165 - 458 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4
8DKSA 2.45 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SO9 Type1 165 - 459 0 SEP346 None Interleukin-1 receptor-associated kinase 4
8DKSB 2.45 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SO9 Type1 164 - 459 0 SEP346 None Interleukin-1 receptor-associated kinase 4
8WTFA 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CG Type1 165 - 458 0 None None Interleukin-1 receptor-associated kinase 4
6EGDD 2.1 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn J87 Type1 164 - 458 0 None None Interleukin-1 receptor-associated kinase 4
4YO6D 2.32 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GD, 4GD Type1, Allosteric 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6TIAA 2.52 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ND2, ND2, ND2, ND2 Type1, Allosteric, Allosteric, Allosteric 163 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6TIAB 2.52 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ND2, ND2, ND2, ND2 Type1, Allosteric, Allosteric, Allosteric 164 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
9R9KC 1.87 Inactive DFGin‑BLAplus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi A1JDQ Type1 164 - 460 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2NRYA 2.15 Inactive DFGin‑BLBminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4
2NRYB 2.15 Inactive DFGin‑BLBminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4
6EGFB 2.61 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 164 - 460 0 None None Interleukin-1 receptor-associated kinase 4
8TVMD 2.1 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnni VDC Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
4U97B 2.65 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
4U9AB 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
6EG9A 2.414 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni 0LI Type2 164 - 459 0 None None Interleukin-1 receptor-associated kinase 4
6EG9B 2.414 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni 0LI Type2 165 - 459 0 None None Interleukin-1 receptor-associated kinase 4
6EGAA 2.512 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoio APEdist_nnni J8A Type2 166 - 459 0 None None Interleukin-1 receptor-associated kinase 4
6EGAB 2.512 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni J8A Type2 164 - 459 0 None None Interleukin-1 receptor-associated kinase 4
5KX7A 2.8 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 192 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8TVND 1.95 Inactive None‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii VE9 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
2OICC 2.4 None DFGin‑BLAminus in-in none-none nonTYR APEdihe_aaiii APEdist_nnni STU Type1 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K72B 2.22 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii 6QY Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5K7GB 2.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii 6R0 Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
5W84B 2.9 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii 9YY Type1 168 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6LXYB 2.19 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 163 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
8TVMC 2.1 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii VDC Type1 160 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
6EGDA 2.1 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn J87 Type1 165 - 458 0 None None Interleukin-1 receptor-associated kinase 4
6EGED 1.401 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn DL1 Type1 164 - 457 0 None None Interleukin-1 receptor-associated kinase 4
4U97A 2.65 None DFGin‑BLAminus in-in none-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
4U9AA 2.8 None DFGin‑BLAminus in-in none-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4

TKL_IRAK4 (Interleukin-1 receptor-associated kinase 4)

Total number of chains: 284
Active chains: 87
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 271 95.4% AF-Q9NWZ3-K1A
DFGout None 4 1.4% 6EG9A
DFGin None 3 1.1% 8TVMD
DFGin BLBminus 2 0.7% 2NRYA
None None 2 0.7% 8TVND
DFGin BLAplus 1 0.4% 9R9KC
DFGin BLBtrans 1 0.4% 6EGFB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
IRAK4_HUMAN 2OIDD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN AF-Q9NWZ3-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 167 - 460 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN AF-Q9NWZ3-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 167 - 460 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OIBA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OIBC 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6F3GA 2.37 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii CJN Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6F3GB 2.37 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii CJN Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6N8GA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6N8GC 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6N8GD 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7C2VA 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FJ0 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7C2VB 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FJ0 Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7C2VC 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FJ0 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7C2VD 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FJ0 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OICA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OICB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OICD 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4XS2B 2.73 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 42P Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4YO6B 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4GD Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4YP8A 2.641 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTLA 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTLB 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTLC 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTMA 2.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S2 Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTMB 2.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S2 Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTMD 2.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S2 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTNB 2.23 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S3 Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K72A 2.22 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QY Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K72C 2.22 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QY Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K72D 2.22 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QY Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K75A 2.03 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QX Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K76B 2.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6R1 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K7GA 2.23 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6R0 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K7GC 2.23 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6R0 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K7GD 2.23 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6R0 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K7IA 2.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QZ Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K7IB 2.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QZ Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5KX7B 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6YD Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5KX8A 2.671 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6YE Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5KX8B 2.671 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6YE Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5KX8D 2.671 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6YE Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5T1SD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 76Q Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4Y73D 2.14 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XPY Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6MOMA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JX4 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6MOMC 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JX4 Type1 163 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA3A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWX Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA3H0A0 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWX Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA4A 2.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW1 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA4B 2.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW1 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA4C 2.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW1 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA4D 2.33 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5W84A 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 9YY Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCEB 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVD Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCED 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVD Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCEE 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVD Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCVA 2.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVG Type1 163 - 458 0 SEP284,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCWA 2.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVA Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCWB 2.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVA Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCWC 2.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVA Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCWD 2.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVA Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2NRYC 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2NRYD 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 460 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TVMB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii VDC Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TVNA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii VE9 Type1 167 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6THXA 1.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii N9Z Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6THZA 2.38 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NB5 Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6TI8A 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NBW Type1 165 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6TI8B 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NBW Type1 165 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6TI8C 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NBW Type1 164 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6TI8D 2.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NBW Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG3A 2.11 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B4U Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9JA 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDR Type1 161 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9JB 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDR Type1 161 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9JC 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDR Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9JD 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDR Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9KA 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDQ Type1 162 - 460 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9KB 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDQ Type1 158 - 460 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O9DC 2.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LTY Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6UYAC 1.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QL7 Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8W3WA 1.976 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFO Type1 162 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8W3WB 1.976 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFO Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8W3WC 1.976 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFO Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8W3WD 1.976 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFO Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8ATLAAA 2.464 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii O6X Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8ATLBBB 2.464 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii O6X Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EGEA 1.401 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DL1 Type1 165 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5T1SB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 76Q Type1.5_Back 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OIDA 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OIDB 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OIDC 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 166 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7C2WA 3.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YTH, FJ9 Allosteric, Type1 164 - 458 0 SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7C2WB 3.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YTH, FJ9 Allosteric, Type1 163 - 458 0 SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7C2WC 3.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YTH, FJ9 Allosteric, Type1 164 - 458 0 SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7C2WD 3.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YTH, FJ9 Allosteric, Type1 164 - 458 0 SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2O8YA 2.4 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 165 - 459 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2O8YB 2.4 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 165 - 459 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OIBB 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OIBD 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6F3DA 2.38 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CJT Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6F3DB 2.38 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CJT Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6F3EA 2.67 Inactive DFGin‑BLAminus in-out none-in nonTYR APEdihe_aaiii APEdist_iiii CJQ Type1 164 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6F3EB 2.67 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CJQ Type1 164 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6N8GB 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8BR5AAA 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R73 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8BR5BBB 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R73 Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8BR5CCC 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R73 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8BR5DDD 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R73 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4XS2A 2.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 42P Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4XS2C 2.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 42P Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4XS2D 2.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 42P Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4YO6A 2.32 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GD Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4YO6C 2.32 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GD Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4YP8B 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4YP8C 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4YP8D 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTLD 2.39 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTMC 2.66 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S2 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTNA 2.23 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S3 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTNC 2.23 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S3 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4ZTND 2.23 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S3 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K75B 2.03 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6QX Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K75C 2.03 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6QX Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K75D 2.03 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6QX Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K76A 2.74 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6R1 Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5KX8C 2.671 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6YE Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5T1SA 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76Q Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5T1SC 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76Q Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5T1TA 2.34 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76P Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5T1TB 2.34 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76P Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5T1TC 2.34 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76P Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5T1TD 2.34 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 76P Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4Y73A 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XPY Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4Y73B 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XPY Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4Y73C 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XPY Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6MOMB 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii JX4 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6MOMD 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii JX4 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA2A 1.99 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW0 Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA2B 1.99 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW0 Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA5A 1.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWY Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA5B 1.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWY Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA5C 1.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWY Type1 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA5D 1.73 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWY Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA6A 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWZ Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA6B 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWZ Type1 166 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA6C 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWZ Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9NA6D 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BWZ Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O8UA 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LS7 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O8UB 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LS7 Type1 160 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O8UC 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LS7 Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O8UD 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LS7 Type1 162 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5W85A 2.25 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 9YS Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5W85B 2.25 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 9YS Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6LXYA 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6LXYD 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 162 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6LXYE 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6VQLA 2.069 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R7S Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6VQLB 2.069 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R7S Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6VQLC 2.069 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R7S Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6VQLD 2.069 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R7S Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCEA 1.89 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ZVD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8SCVB 2.69 Inactive DFGin‑BLAminus in-none none-out nonTYR APEdihe_aannn APEdist_ooon ZVG Type1 165 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2NRUA 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T12 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2NRUB 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T12 Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2NRUC 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T12 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2NRUD 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T12 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4RMZA 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T20 Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4RMZB 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T20 Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TVMA 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VDC Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TVNB 1.95 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VE9 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TVNC 1.95 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VE9 Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TX0A 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VEU Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TX0B 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii VEU Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8UCBA 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii X1T Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8UCBB 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii X1T Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8UCBC 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii X1T Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8UCBD 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii X1T Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8UCCA 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii WFQ Type1 160 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8UCCB 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii WFQ Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6THWA 2.44 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii NBK Type1 164 - 458 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6THWB 2.44 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii NBK Type1 164 - 458 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6THXB 1.99 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii N9Z Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6THZB 2.38 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii NB5 Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG2A 3.031 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B6I Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG2B 3.031 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B6I Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG2C 3.031 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B6I Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG2D 3.031 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B6I Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG3B 2.11 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B4U Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG5A 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B7R Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG5B 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B7R Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9GA 1.88 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9GB 1.88 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9GC 1.88 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9GD 1.88 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9KD 1.87 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1JDQ Type1 164 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O94A 1.98 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LRS Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O94B 1.98 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LRS Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O94C 1.98 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LRS Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O94D 1.98 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LRS Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O95A 1.77 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LSV Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O95B 1.77 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LSV Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O95C 1.77 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LSV Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O95D 1.77 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LSV Type1 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O9DA 2.51 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LTY Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O9DB 2.51 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LTY Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6O9DD 2.51 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LTY Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6UYAA 1.74 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii QL7 Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6UYAB 1.74 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii QL7 Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6UYAD 1.74 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii QL7 Type1 162 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6F3IA 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CKN Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6F3IB 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CKN Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6RFIA 2.31 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii K1H Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6RFIB 2.31 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii K1H Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6RFJA 2.61 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii K1E Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6RFJB 2.61 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii K1E Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG1A 2.07 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B8I Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 7QG1B 2.07 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii B8I Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UIQA 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BV Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UIQB 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BV Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UIQC 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BV Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UIQD 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BV Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UIRA 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BY Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UIRB 2.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8BY Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UISA 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8C1 Type1 165 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UISB 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8C1 Type1 165 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UISC 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8C1 Type1 162 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UISD 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8C1 Type1 165 - 458 0 TPO342,TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UITA 1.84 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CD Type1 162 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UITB 1.84 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CD Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UIUA 2.02 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CG Type1 165 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5UIUB 2.02 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CG Type1 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8W3XA 1.765 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFH Type1 162 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8W3XB 1.765 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFH Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8W3XC 1.765 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFH Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8W3XD 1.765 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1AFH Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V1OA 2.92 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V1OB 2.92 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V1OC 2.92 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V1OD 2.92 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii Y9T Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V2FA 2.09 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJU Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V2FB 2.09 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJU Type1 162 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V2FC 2.09 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJU Type1 160 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V2FD 2.09 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJU Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V2LA 2.43 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK0 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V2LB 2.43 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK0 Type1 163 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V2LC 2.43 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK0 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8V2LD 2.43 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK0 Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8ATBAAA 2.35 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii O0H Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8ATBBBB 2.35 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii O0H Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8ATNAAA 2.171 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii O06 Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8ATNBBB 2.171 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii O06 Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8BR6AAA 2.167 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R6I Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8BR6BBB 2.167 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R6I Type1 165 - 459 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8BR7AAA 2.119 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R6R Type1 165 - 458 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8BR7BBB 2.119 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii R6R Type1 165 - 458 0 TPO345,SEP346 K400A,E401A,E402A Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8DKSA 2.45 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SO9 Type1 165 - 459 0 SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8DKSB 2.45 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SO9 Type1 164 - 459 0 SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8WTFA 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 8CG Type1 165 - 458 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EGDD 2.1 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn J87 Type1 164 - 458 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4YO6D 2.32 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GD, 4GD Type1, Allosteric 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6TIAA 2.52 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ND2, ND2, ND2, ND2 Type1, Allosteric, Allosteric, Allosteric 163 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6TIAB 2.52 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ND2, ND2, ND2, ND2 Type1, Allosteric, Allosteric, Allosteric 164 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 9R9KC 1.87 Inactive DFGin‑BLAplus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi A1JDQ Type1 164 - 460 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2NRYA 2.15 Inactive DFGin‑BLBminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2NRYB 2.15 Inactive DFGin‑BLBminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EGFB 2.61 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 164 - 460 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TVMD 2.1 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnni VDC Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4U97B 2.65 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4U9AB 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EG9A 2.414 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni 0LI Type2 164 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EG9B 2.414 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni 0LI Type2 165 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EGAA 2.512 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoio APEdist_nnni J8A Type2 166 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EGAB 2.512 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni J8A Type2 164 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5KX7A 2.8 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 192 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TVND 1.95 Inactive None‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii VE9 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 2OICC 2.4 None DFGin‑BLAminus in-in none-none nonTYR APEdihe_aaiii APEdist_nnni STU Type1 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K72B 2.22 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii 6QY Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5K7GB 2.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii 6R0 Type1 165 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 5W84B 2.9 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii 9YY Type1 168 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6LXYB 2.19 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 163 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 8TVMC 2.1 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii VDC Type1 160 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EGDA 2.1 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn J87 Type1 165 - 458 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 6EGED 1.401 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn DL1 Type1 164 - 457 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4U97A 2.65 None DFGin‑BLAminus in-in none-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
IRAK4_HUMAN 4U9AA 2.8 None DFGin‑BLAminus in-in none-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens

TKL_IRAK4 (Interleukin-1 receptor-associated kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism