PRKAA2 (5'-AMP-activated protein kinase catalytic subunit alpha-2)

Group: CAMK
Uniprot: AAPK2_HUMAN
Domain boundary: 16 - 268


Total number of chains: 22
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-P54646-K1A
DFGin ABAminus 3 5ISOA
DFGin BLBminus 1 7MYJA
DFGin None 6 6B1UA
DFGout BBAminus 2 2YZAA
None None 2 3AQVA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
5ISOA 2.63 Inactive DFGin ABAminus out-none in-in STU 992 Type1 Allosteric 9 - 551 None None 0
5ISOC 2.63 Inactive DFGin ABAminus out-none in-in STU 992 Type1 Allosteric 9 - 550 None None 0
6B1UC 2.77 Inactive DFGin ABAminus out-out in-in STU CG7 Type1 Allosteric 9 - 552 None X172 0
AF-P54646-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 276 None None 0
4ZHXA 2.99 Active DFGin BLAminus in-in in-in 4O7 Type1 9 - 550 None X172 0
4CFFA 3.924 Inactive DFGin BLAminus out-out in-in STU Type1 8 - 551 None X172 0
8BIKA 2.5 Active DFGin BLAminus out-in in-in STU QTN Type1 Allosteric 8 - 551 None None 0
8BIKD 2.5 Active DFGin BLAminus out-in in-in STU QTN Type1 Allosteric 9 - 551 None None 0
6B2EA 3.8 None DFGin BLAminus out-none in-out STU CG7 Type1 Allosteric 9 - 551 None X172 0
4CFEA 3.023 Inactive DFGin BLAminus out-out in-in STU 992 Type1 Allosteric 8 - 551 None X172 0
4CFEC 3.023 Inactive DFGin BLAminus out-out in-in STU 992 Type1 Allosteric 10 - 551 None X172 0
7MYJA 2.95 Inactive DFGin BLBminus out-in in-in 4O7 ZQV Type1 Allosteric 7 - 551 None X172 0
7MYJC 2.95 Inactive DFGin None out-in in-in 4O7 Type1 8 - 551 None X172 0
5EZVA 2.99 Inactive DFGin None in-in in-in STU C1V Type1 Allosteric 8 - 551 None X172 0
5EZVC 2.99 Inactive DFGin None out-in in-in STU C1V Type1 Allosteric 9 - 551 None X172 0
4ZHXC 2.99 Inactive DFGin None out-out in-out 4O7 C1V Type1 Allosteric 9 - 551 None X172 0
6B1UA 2.77 Inactive DFGin None out-in in-in STU CG7 Type1 Allosteric 8 - 550 None X172 0
4CFFC 3.924 Inactive DFGin None out-out in-in STU C1V Type1 Allosteric 10 - 551 None X172 0
2H6DA 1.85 Inactive DFGout BBAminus out-out out-none No_ligand No_ligand 10 - 278 None None 13
2YZAA 3.02 Inactive DFGout BBAminus out-out out-none No_ligand No_ligand 10 - 278 T172D None 11
3AQVA 2.08 Inactive None None out-out out-none TAK Type1 7 - 279 T172D None 6
6BX6A 2.9 Inactive None None out-none out-none EDJ Type1 13 - 277 T172D None 16

PRKAA2 (5'-AMP-activated protein kinase catalytic subunit alpha-2)

Group: CAMK
Total number of chains: 22
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-P54646-K1A
DFGin ABAminus 3 5ISOA
DFGin BLBminus 1 7MYJA
DFGin None 6 6B1UA
DFGout BBAminus 2 2YZAA
None None 2 3AQVA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens AAPK2_HUMAN 5ISOA 2.63 Inactive DFGin ABAminus out-none in-in STU 992 Type1 Allosteric 9 - 551 None None 0
Homo sapiens AAPK2_HUMAN 5ISOC 2.63 Inactive DFGin ABAminus out-none in-in STU 992 Type1 Allosteric 9 - 550 None None 0
Homo sapiens AAPK2_HUMAN 6B1UC 2.77 Inactive DFGin ABAminus out-out in-in STU CG7 Type1 Allosteric 9 - 552 None X172 0
Homo sapiens AAPK2_HUMAN AF-P54646-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 276 None None 0
Homo sapiens AAPK2_HUMAN 4ZHXA 2.99 Active DFGin BLAminus in-in in-in 4O7 Type1 9 - 550 None X172 0
Homo sapiens AAPK2_HUMAN 4CFFA 3.924 Inactive DFGin BLAminus out-out in-in STU Type1 8 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 8BIKA 2.5 Active DFGin BLAminus out-in in-in STU QTN Type1 Allosteric 8 - 551 None None 0
Homo sapiens AAPK2_HUMAN 8BIKD 2.5 Active DFGin BLAminus out-in in-in STU QTN Type1 Allosteric 9 - 551 None None 0
Homo sapiens AAPK2_HUMAN 6B2EA 3.8 None DFGin BLAminus out-none in-out STU CG7 Type1 Allosteric 9 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 4CFEA 3.023 Inactive DFGin BLAminus out-out in-in STU 992 Type1 Allosteric 8 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 4CFEC 3.023 Inactive DFGin BLAminus out-out in-in STU 992 Type1 Allosteric 10 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 7MYJA 2.95 Inactive DFGin BLBminus out-in in-in 4O7 ZQV Type1 Allosteric 7 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 7MYJC 2.95 Inactive DFGin None out-in in-in 4O7 Type1 8 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 5EZVA 2.99 Inactive DFGin None in-in in-in STU C1V Type1 Allosteric 8 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 5EZVC 2.99 Inactive DFGin None out-in in-in STU C1V Type1 Allosteric 9 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 4ZHXC 2.99 Inactive DFGin None out-out in-out 4O7 C1V Type1 Allosteric 9 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 6B1UA 2.77 Inactive DFGin None out-in in-in STU CG7 Type1 Allosteric 8 - 550 None X172 0
Homo sapiens AAPK2_HUMAN 4CFFC 3.924 Inactive DFGin None out-out in-in STU C1V Type1 Allosteric 10 - 551 None X172 0
Homo sapiens AAPK2_HUMAN 2H6DA 1.85 Inactive DFGout BBAminus out-out out-none No_ligand No_ligand 10 - 278 None None 13
Homo sapiens AAPK2_HUMAN 2YZAA 3.02 Inactive DFGout BBAminus out-out out-none No_ligand No_ligand 10 - 278 T172D None 11
Homo sapiens AAPK2_HUMAN 3AQVA 2.08 Inactive None None out-out out-none TAK Type1 7 - 279 T172D None 6
Homo sapiens AAPK2_HUMAN 6BX6A 2.9 Inactive None None out-none out-none EDJ Type1 13 - 277 T172D None 16

PRKAA2 (5'-AMP-activated protein kinase catalytic subunit alpha-2)

No non-human structures known.