Ligand: 877

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 2GMXA
DFGin None 1 50.0% 2GMXB
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC MAPK8 MK08_HUMAN 2GMXA 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 877 Type1 8 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2GMXB 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 877 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8

Ligand: 877

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 2GMXA
DFGin None 1 50.0% 2GMXB
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK8 MK08_HUMAN 2GMXA 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 877 Type1 8 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 2GMXB 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 877 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens

Ligand: 877

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page

Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism