Ligand: RMF

Total number of chains: 7
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 57.1% 8BU5B
DFGin None 2 28.6% 8BU5E
DFGin BLAminus 1 14.3% 8P81A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK12 CDK12_HUMAN 8BU5B 3.134 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5H 3.134 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRE 3.9 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 714 - 1042 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRH 3.9 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1044 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8P81A 2.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 716 - 1035 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E 3.134 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1047 0 TPO893 None Cyclin-dependent kinase 12

Ligand: RMF

Total number of chains: 7
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 57.1% 8BU5B
DFGin None 2 28.6% 8BU5E
DFGin BLAminus 1 14.3% 8P81A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK12 CDK12_HUMAN 8BU5B 3.134 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU5H 3.134 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 9FMRE 3.9 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 714 - 1042 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 9FMRH 3.9 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1044 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8P81A 2.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 716 - 1035 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU5E 3.134 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 9FMRB 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1047 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens

Ligand: RMF

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism