ROCK2 (Rho-associated protein kinase 2)

Group: AGC
Uniprot: ROCK2_HUMAN
Domain boundary: 92 - 354


Total number of chains: 65
Spatial Dihedral Chains Representative
DFGin BLAminus 37 AF-O75116-K1A
DFGin ABAminus 23 8X92A
DFGin None 1 5U7RD
DFGout BBAminus 4 8GDSC
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
6P5MC 2.65 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 18 - 417 F270Y None 0
6P5MD 2.65 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 18 - 417 F270Y None 0
5U7QA 3.15 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 25 - 417 None None 0
5U7QB 3.15 Inactive DFGin ABAminus in-in in-out No_ligand No_ligand 28 - 417 None None 0
5U7QC 3.15 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 23 - 417 None None 0
5U7QD 3.15 Inactive DFGin ABAminus in-in in-out No_ligand No_ligand 27 - 417 None None 3
5U7RA 3.33 Inactive DFGin ABAminus in-in in-in 81G Type1 25 - 417 None None 0
5U7RC 3.33 Inactive DFGin ABAminus in-in in-out 81G Type1 25 - 417 None None 0
6P5PA 3.3 Inactive DFGin ABAminus in-in in-in O1V Type1 27 - 417 F270Y None 0
6P5PB 3.3 Inactive DFGin ABAminus in-in in-out O1V Type1 27 - 417 F270Y None 5
6P5PC 3.3 Inactive DFGin ABAminus in-in in-in O1V Type1 28 - 416 F270Y None 0
6P5PD 3.3 Inactive DFGin ABAminus in-in in-out O1V Type1 26 - 416 F270Y None 1
8X8YB 3.2 Inactive DFGin ABAminus in-in in-out YEA Type1 29 - 417 None None 2
8X8ZA 2.7 Inactive DFGin ABAminus in-in in-in YEI Type1 31 - 416 None None 0
8X8ZB 2.7 Inactive DFGin ABAminus in-in in-out YEI Type1 29 - 417 None None 7
8X92A 2.2 Inactive DFGin ABAminus in-in in-in YEW Type1 29 - 416 None None 0
8X92B 2.2 Inactive DFGin ABAminus in-in in-out YEW Type1 29 - 417 None None 10
4WOTA 2.93 Inactive DFGin ABAminus in-in in-out 3SG Type1 22 - 417 None None 3
4WOTB 2.93 Inactive DFGin ABAminus in-in in-in 3SG Type1 22 - 417 None None 0
4WOTC 2.93 Inactive DFGin ABAminus in-in in-in 3SG Type1 22 - 417 None None 0
4WOTD 2.93 Inactive DFGin ABAminus in-in in-out 3SG Type1 23 - 417 None None 2
4L6QA 2.79 Inactive DFGin ABAminus in-in in-in 1WU Type1 27 - 417 None None 0
4L6QB 2.79 Inactive DFGin ABAminus in-out in-in 1WU Type1 27 - 417 None None 0
AF-O75116-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 84 - 362 None None 0
5U7RB 3.33 Active DFGin BLAminus in-in in-in 81G Type1 25 - 417 None None 0
6P5MA 2.65 Inactive DFGin BLAminus in-in in-out O1S Type1 18 - 417 F270Y None 0
6P5MB 2.65 Inactive DFGin BLAminus in-in in-out O1S Type1 18 - 417 F270Y None 0
8X8XA 2.6 Active DFGin BLAminus in-in in-in YDW Type1 32 - 417 None None 0
8X8XB 2.6 Inactive DFGin BLAminus in-in in-out YDW Type1 29 - 417 None None 9
8X8YA 3.2 Active DFGin BLAminus in-in in-in YEA Type1 31 - 417 None None 0
7JOVA 2.586 None DFGin BLAminus in-in in-none VFS Type1 25 - 417 None None 6
7JOVB 2.586 None DFGin BLAminus in-in in-none VFS Type1 23 - 417 None None 8
7JOVC 2.586 Inactive DFGin BLAminus in-in in-out VFS Type1 23 - 417 None None 2
7JOVD 2.586 None DFGin BLAminus in-in in-none VFS Type1 25 - 417 None None 15
7JOVE 2.586 None DFGin BLAminus in-in in-none VFS Type1 23 - 417 None None 3
7JOVF 2.586 Active DFGin BLAminus in-in in-in VFS Type1 25 - 417 None None 0
7JOVG 2.586 None DFGin BLAminus in-in in-none VFS Type1 23 - 417 None None 3
7JOVH 2.586 Active DFGin BLAminus in-in in-in VFS Type1 25 - 417 None None 0
7JNTA 2.214 None DFGin BLAminus in-in in-none VFA Type1 25 - 417 None None 6
7JNTB 2.214 None DFGin BLAminus in-in in-none VFA Type1 23 - 417 None None 8
7JNTC 2.214 Inactive DFGin BLAminus in-in in-out VFA Type1 23 - 417 None None 4
7JNTD 2.214 None DFGin BLAminus in-in in-none VFA Type1 25 - 417 None None 15
7JNTE 2.214 None DFGin BLAminus in-in in-none VFA Type1 23 - 417 None None 4
7JNTF 2.214 Active DFGin BLAminus in-in in-in VFA Type1 25 - 417 None None 0
7JNTG 2.214 None DFGin BLAminus in-in in-none VFA Type1 23 - 417 None None 3
7JNTH 2.214 Active DFGin BLAminus in-in in-in VFA Type1 25 - 417 None None 0
7P6NA 3.0 Inactive DFGin BLAminus in-in in-out 5YS Type1 24 - 417 None None 3
7P6NB 3.0 None DFGin BLAminus in-in in-none 5YS Type1 25 - 417 None None 4
7P6NC 3.0 None DFGin BLAminus in-in in-none 5YS Type1 23 - 417 None None 6
7P6ND 3.0 Inactive DFGin BLAminus in-in in-out 5YS Type1 25 - 417 None None 0
7P6NE 3.0 None DFGin BLAminus in-in in-none 5YS Type1 23 - 417 None None 6
7P6NF 3.0 Inactive DFGin BLAminus in-in in-out 5YS Type1 25 - 417 None None 0
7P6NG 3.0 None DFGin BLAminus in-in in-none 5YS Type1 25 - 417 None None 4
7P6NH 3.0 None DFGin BLAminus in-in in-none 5YS Type1 25 - 417 None None 15
9EP8A 2.63 Inactive DFGin BLAminus in-in in-out A1H6L Type1 22 - 417 None None 2
9EP8B 2.63 None DFGin BLAminus in-in in-none A1H6L Type1 24 - 417 None None 12
9EP8C 2.63 None DFGin BLAminus in-in in-none A1H6L Type1 24 - 417 None None 12
9EP8D 2.63 Inactive DFGin BLAminus in-in in-out A1H6L Type1 22 - 417 None None 2
6ED6A 2.86 Active DFGin BLAminus in-in in-in J0P Type1 27 - 415 None None 0
6ED6B 2.86 Inactive DFGin BLAminus in-in in-out J0P Type1.5_Front 28 - 416 None None 12
5U7RD 3.33 Inactive DFGin None in-in in-out 81G Type1 25 - 417 None None 2
8GDSA 2.71 Inactive DFGout BBAminus out-out in-out Z8O Type1 24 - 417 None None 2
8GDSB 2.71 Inactive DFGout BBAminus out-none in-out Z8O Type1 24 - 417 None None 3
8GDSC 2.71 Inactive DFGout BBAminus out-none in-out Z8O Type1 24 - 417 None None 4
8GDSD 2.71 Inactive DFGout BBAminus out-none in-in Z8O Type1.5_Front 24 - 417 None None 5

ROCK2 (Rho-associated protein kinase 2)

Group: AGC
Total number of chains: 68
Spatial Dihedral Chains Representative
DFGin BLAminus 38 AF-O75116-K1A
DFGin ABAminus 25 8X92A
DFGin None 1 5U7RD
DFGout BBAminus 4 8GDSC
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Bos taurus ROCK2_BOVIN 2F2UA 2.4 Inactive DFGin ABAminus in-in in-in M77 Type1 27 - 417 None None 0
Bos taurus ROCK2_BOVIN 2H9VA 3.1 Inactive DFGin ABAminus in-in in-in Y27 Type1 25 - 417 None None 0
Bos taurus ROCK2_BOVIN 2F2UB 2.4 Inactive DFGin BLAminus in-in in-out M77 Type1 27 - 417 None None 0
Homo sapiens ROCK2_HUMAN 6P5MC 2.65 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 18 - 417 F270Y None 0
Homo sapiens ROCK2_HUMAN 6P5MD 2.65 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 18 - 417 F270Y None 0
Homo sapiens ROCK2_HUMAN 5U7QA 3.15 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 5U7QB 3.15 Inactive DFGin ABAminus in-in in-out No_ligand No_ligand 28 - 417 None None 0
Homo sapiens ROCK2_HUMAN 5U7QC 3.15 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 23 - 417 None None 0
Homo sapiens ROCK2_HUMAN 5U7QD 3.15 Inactive DFGin ABAminus in-in in-out No_ligand No_ligand 27 - 417 None None 3
Homo sapiens ROCK2_HUMAN 5U7RA 3.33 Inactive DFGin ABAminus in-in in-in 81G Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 5U7RC 3.33 Inactive DFGin ABAminus in-in in-out 81G Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 6P5PA 3.3 Inactive DFGin ABAminus in-in in-in O1V Type1 27 - 417 F270Y None 0
Homo sapiens ROCK2_HUMAN 6P5PB 3.3 Inactive DFGin ABAminus in-in in-out O1V Type1 27 - 417 F270Y None 5
Homo sapiens ROCK2_HUMAN 6P5PC 3.3 Inactive DFGin ABAminus in-in in-in O1V Type1 28 - 416 F270Y None 0
Homo sapiens ROCK2_HUMAN 6P5PD 3.3 Inactive DFGin ABAminus in-in in-out O1V Type1 26 - 416 F270Y None 1
Homo sapiens ROCK2_HUMAN 8X8YB 3.2 Inactive DFGin ABAminus in-in in-out YEA Type1 29 - 417 None None 2
Homo sapiens ROCK2_HUMAN 8X8ZA 2.7 Inactive DFGin ABAminus in-in in-in YEI Type1 31 - 416 None None 0
Homo sapiens ROCK2_HUMAN 8X8ZB 2.7 Inactive DFGin ABAminus in-in in-out YEI Type1 29 - 417 None None 7
Homo sapiens ROCK2_HUMAN 8X92A 2.2 Inactive DFGin ABAminus in-in in-in YEW Type1 29 - 416 None None 0
Homo sapiens ROCK2_HUMAN 8X92B 2.2 Inactive DFGin ABAminus in-in in-out YEW Type1 29 - 417 None None 10
Homo sapiens ROCK2_HUMAN 4WOTA 2.93 Inactive DFGin ABAminus in-in in-out 3SG Type1 22 - 417 None None 3
Homo sapiens ROCK2_HUMAN 4WOTB 2.93 Inactive DFGin ABAminus in-in in-in 3SG Type1 22 - 417 None None 0
Homo sapiens ROCK2_HUMAN 4WOTC 2.93 Inactive DFGin ABAminus in-in in-in 3SG Type1 22 - 417 None None 0
Homo sapiens ROCK2_HUMAN 4WOTD 2.93 Inactive DFGin ABAminus in-in in-out 3SG Type1 23 - 417 None None 2
Homo sapiens ROCK2_HUMAN 4L6QA 2.79 Inactive DFGin ABAminus in-in in-in 1WU Type1 27 - 417 None None 0
Homo sapiens ROCK2_HUMAN 4L6QB 2.79 Inactive DFGin ABAminus in-out in-in 1WU Type1 27 - 417 None None 0
Homo sapiens ROCK2_HUMAN AF-O75116-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 84 - 362 None None 0
Homo sapiens ROCK2_HUMAN 5U7RB 3.33 Active DFGin BLAminus in-in in-in 81G Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 6P5MA 2.65 Inactive DFGin BLAminus in-in in-out O1S Type1 18 - 417 F270Y None 0
Homo sapiens ROCK2_HUMAN 6P5MB 2.65 Inactive DFGin BLAminus in-in in-out O1S Type1 18 - 417 F270Y None 0
Homo sapiens ROCK2_HUMAN 8X8XA 2.6 Active DFGin BLAminus in-in in-in YDW Type1 32 - 417 None None 0
Homo sapiens ROCK2_HUMAN 8X8XB 2.6 Inactive DFGin BLAminus in-in in-out YDW Type1 29 - 417 None None 9
Homo sapiens ROCK2_HUMAN 8X8YA 3.2 Active DFGin BLAminus in-in in-in YEA Type1 31 - 417 None None 0
Homo sapiens ROCK2_HUMAN 7JOVA 2.586 None DFGin BLAminus in-in in-none VFS Type1 25 - 417 None None 6
Homo sapiens ROCK2_HUMAN 7JOVB 2.586 None DFGin BLAminus in-in in-none VFS Type1 23 - 417 None None 8
Homo sapiens ROCK2_HUMAN 7JOVC 2.586 Inactive DFGin BLAminus in-in in-out VFS Type1 23 - 417 None None 2
Homo sapiens ROCK2_HUMAN 7JOVD 2.586 None DFGin BLAminus in-in in-none VFS Type1 25 - 417 None None 15
Homo sapiens ROCK2_HUMAN 7JOVE 2.586 None DFGin BLAminus in-in in-none VFS Type1 23 - 417 None None 3
Homo sapiens ROCK2_HUMAN 7JOVF 2.586 Active DFGin BLAminus in-in in-in VFS Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 7JOVG 2.586 None DFGin BLAminus in-in in-none VFS Type1 23 - 417 None None 3
Homo sapiens ROCK2_HUMAN 7JOVH 2.586 Active DFGin BLAminus in-in in-in VFS Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 7JNTA 2.214 None DFGin BLAminus in-in in-none VFA Type1 25 - 417 None None 6
Homo sapiens ROCK2_HUMAN 7JNTB 2.214 None DFGin BLAminus in-in in-none VFA Type1 23 - 417 None None 8
Homo sapiens ROCK2_HUMAN 7JNTC 2.214 Inactive DFGin BLAminus in-in in-out VFA Type1 23 - 417 None None 4
Homo sapiens ROCK2_HUMAN 7JNTD 2.214 None DFGin BLAminus in-in in-none VFA Type1 25 - 417 None None 15
Homo sapiens ROCK2_HUMAN 7JNTE 2.214 None DFGin BLAminus in-in in-none VFA Type1 23 - 417 None None 4
Homo sapiens ROCK2_HUMAN 7JNTF 2.214 Active DFGin BLAminus in-in in-in VFA Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 7JNTG 2.214 None DFGin BLAminus in-in in-none VFA Type1 23 - 417 None None 3
Homo sapiens ROCK2_HUMAN 7JNTH 2.214 Active DFGin BLAminus in-in in-in VFA Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 7P6NA 3.0 Inactive DFGin BLAminus in-in in-out 5YS Type1 24 - 417 None None 3
Homo sapiens ROCK2_HUMAN 7P6NB 3.0 None DFGin BLAminus in-in in-none 5YS Type1 25 - 417 None None 4
Homo sapiens ROCK2_HUMAN 7P6NC 3.0 None DFGin BLAminus in-in in-none 5YS Type1 23 - 417 None None 6
Homo sapiens ROCK2_HUMAN 7P6ND 3.0 Inactive DFGin BLAminus in-in in-out 5YS Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 7P6NE 3.0 None DFGin BLAminus in-in in-none 5YS Type1 23 - 417 None None 6
Homo sapiens ROCK2_HUMAN 7P6NF 3.0 Inactive DFGin BLAminus in-in in-out 5YS Type1 25 - 417 None None 0
Homo sapiens ROCK2_HUMAN 7P6NG 3.0 None DFGin BLAminus in-in in-none 5YS Type1 25 - 417 None None 4
Homo sapiens ROCK2_HUMAN 7P6NH 3.0 None DFGin BLAminus in-in in-none 5YS Type1 25 - 417 None None 15
Homo sapiens ROCK2_HUMAN 9EP8A 2.63 Inactive DFGin BLAminus in-in in-out A1H6L Type1 22 - 417 None None 2
Homo sapiens ROCK2_HUMAN 9EP8B 2.63 None DFGin BLAminus in-in in-none A1H6L Type1 24 - 417 None None 12
Homo sapiens ROCK2_HUMAN 9EP8C 2.63 None DFGin BLAminus in-in in-none A1H6L Type1 24 - 417 None None 12
Homo sapiens ROCK2_HUMAN 9EP8D 2.63 Inactive DFGin BLAminus in-in in-out A1H6L Type1 22 - 417 None None 2
Homo sapiens ROCK2_HUMAN 6ED6A 2.86 Active DFGin BLAminus in-in in-in J0P Type1 27 - 415 None None 0
Homo sapiens ROCK2_HUMAN 6ED6B 2.86 Inactive DFGin BLAminus in-in in-out J0P Type1.5_Front 28 - 416 None None 12
Homo sapiens ROCK2_HUMAN 5U7RD 3.33 Inactive DFGin None in-in in-out 81G Type1 25 - 417 None None 2
Homo sapiens ROCK2_HUMAN 8GDSA 2.71 Inactive DFGout BBAminus out-out in-out Z8O Type1 24 - 417 None None 2
Homo sapiens ROCK2_HUMAN 8GDSB 2.71 Inactive DFGout BBAminus out-none in-out Z8O Type1 24 - 417 None None 3
Homo sapiens ROCK2_HUMAN 8GDSC 2.71 Inactive DFGout BBAminus out-none in-out Z8O Type1 24 - 417 None None 4
Homo sapiens ROCK2_HUMAN 8GDSD 2.71 Inactive DFGout BBAminus out-none in-in Z8O Type1.5_Front 24 - 417 None None 5

ROCK2 (Rho-associated protein kinase 2)

Group: AGC
Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin BLAminus 1 2F2UB
DFGin ABAminus 2 2F2UA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Bos taurus ROCK2_BOVIN 2F2UA 2.4 Inactive DFGin ABAminus in-in in-in M77 Type1 27 - 417 None None 0
Bos taurus ROCK2_BOVIN 2H9VA 3.1 Inactive DFGin ABAminus in-in in-in Y27 Type1 25 - 417 None None 0
Bos taurus ROCK2_BOVIN 2F2UB 2.4 Inactive DFGin BLAminus in-in in-out M77 Type1 27 - 417 None None 0