Ligand: ACP

Total number of chains: 91
Active chains: 10
Total number of genes: 19
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 63 69.2% 5UI0B
DFGin BLBplus 10 11.0% 4ANBA
DFGin ABAminus 6 6.6% 6EQ9A
DFGin BLBminus 5 5.5% 7KJCA
DFGin BLAplus 2 2.2% 6PNXB
DFGin None 2 2.2% 4C3PA
DFGinter None 2 2.2% 4C3RA
None None 1 1.1% 6C83A
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC PRKCI KPCI_HUMAN 5LI9A 1.79 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 248 - 589 0 TPO412,TPO564 None Protein kinase C iota type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7QA 2.0 Inactive DFGin‑BLBplus none-none out-out nonTYR APEdihe_aaiii APEdist_nnno ACP ATPlike 56 - 340 0 None None Ribosomal protein S6 kinase alpha-1
CAMK AURKA AURKA_HUMAN 4C3PD 2.69 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaooi APEdist_nooo ACP ATPlike 125 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G15A 2.06 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 126 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPFA 2.3 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 128 - 392 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3PA 2.69 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaooi APEdist_oooo ACP ATPlike 125 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3RA 2.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83B 2.55 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83A 2.55 Inactive None‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 389 0 None None Aurora kinase A
CAMK DAPK1 DAPK1_HUMAN 3ZXTB 2.65 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn ACP ATPlike 7 - 276 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTC 2.65 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ACP ATPlike 5 - 276 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTD 2.65 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn ACP ATPlike 7 - 276 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTA 2.65 Inactive DFGin‑BLBminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ACP ATPlike 7 - 276 0 None None Death-associated protein kinase 1
CK1 CSNK1D KC1D_HUMAN 6RU6A 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 3 - 294 0 None None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU6B 2.05 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ACP ATPlike 3 - 294 0 None None Casein kinase I isoform delta
CMGC CSNK2A1 CSK21_HUMAN 4NH1A 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ACP ATPlike 3 - 332 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 4NH1B 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ACP ATPlike 2 - 333 0 None None Casein kinase II subunit alpha
CMGC MAPK1 MK01_HUMAN 5V60A 2.18 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 10 - 358 0 TPO185,PTR187 None Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 6EQ9B 1.83 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno ACP ATPlike 47 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 6EQ9A 1.83 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_nnno ACP, C15 ATPlike, Allosteric 46 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 8VTFA 2.4 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaiii APEdist_oooo A1ACP Type1 45 - 400 0 None None Mitogen-activated protein kinase 10
OTHER RNASEL RN5A_HUMAN 4OAVB 2.1 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ACP ATPlike 24 - 717 0 None H672N 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVD 2.1 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ACP ATPlike 26 - 719 0 None H672N 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 6U2GA 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEA 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 63 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNED 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 66 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN9A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onoo ACP, 2P7 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEE 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEH 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ACP, 573, 573 ATPlike, Type3, Allosteric 66 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN2A 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo EUI, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ANBA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YQY, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
TKL BRAF BRAF_HUMAN 6U2GB 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ACP ATPlike 451 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL RIPK2 RIPK2_HUMAN 5NG0A 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 6 - 300 0 None L294F Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG0B 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii ACP ATPlike 5 - 299 0 None L294F Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3A 3.23 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ACP ATPlike 6 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3B 3.23 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn ACP ATPlike 6 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2
TYR EPHA2 EPHA2_HUMAN 7KJAB 1.75 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ACP ATPlike 590 - 965 0 None None Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCA 2.3 Inactive DFGin‑BLBminus in-in out-none TYR APEdihe_niiai APEdist_aaai ACP ATPlike 590 - 976 0 None S901E Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCB 2.3 Inactive DFGin‑BLBminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ACP ATPlike 590 - 965 0 None S901E Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJAA 1.75 Inactive DFGin‑BLBminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ACP ATPlike 590 - 976 0 None None Ephrin type-A receptor 2
TYR FGFR1 FGFR1_HUMAN 3GQIA 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 464 - 770 0 PTR653,PTR654,PTR766 C488A,Y583F,C584S,Y585F Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 2PWLA 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,N549H Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PWLB 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 765 0 None C491A,N549H Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J96B 2.297 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 462 - 766 0 None C491A,K659M Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J98B 2.307 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 461 - 764 0 None C491A,K659Q Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVFA 1.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 467 - 765 0 PTR586,PTR656,PTR657 C491A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 3CLYA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 468 - 772 0 PTR656,PTR657 C491A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99A 1.847 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 466 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99B 1.847 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99C 1.847 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99D 1.847 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 465 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYA 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYB 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 462 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYC 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 462 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYD 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95A 2.377 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95B 2.377 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95C 2.377 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95D 2.377 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5A 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,N549T Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5B 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,N549T Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97A 2.548 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97B 2.548 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97C 2.548 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97D 2.548 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 466 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPA 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,K526E Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPB 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,K526E Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRA 3.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 765 0 None C491A,K641R Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRB 3.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 766 0 None C491A,K641R Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNA 2.909 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 469 - 764 0 None N549H,E565A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNB 2.909 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 469 - 764 0 None N549H,E565A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXA 2.349 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,E565A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXB 2.349 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,E565A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UI0B 2.05 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 462 - 765 0 None C491A,E565A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BA 2.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 765 0 None C491A,E565A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BB 2.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,E565A Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3A 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,E565G Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3B 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,E565G Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5EG3A 2.606 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 466 - 774 0 PTR769 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QA 2.46 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 466 - 765 0 PTR656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QB 2.46 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 766 0 PTR656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QD 2.46 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 765 0 PTR656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QC 2.46 Inactive DFGin‑BLBminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 766 0 PTR656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2
TYR FGFR3 FGFR3_HUMAN 4K33A 2.341 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 459 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXA 2.199 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 456 - 757 0 None C482A,C582S,R669E Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXB 2.199 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 455 - 756 0 None C482A,C582S,R669E Fibroblast growth factor receptor 3
TYR IGF1R IGF1R_HUMAN 1K3AA 2.1 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 988 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 4XLVA 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 1001 - 1310 0 PTR999,PTR1185,PTR1189,PTR1190 Y992F,C1008S Insulin receptor
TYR INSR INSR_HUMAN 1I44A 2.4 Inactive DFGin‑None in-out none-out TYR APEdihe_nnoai APEdist_aaai ACP ATPlike 1013 - 1310 0 None C1008S,Y1011F,D1188A Insulin receptor
TYR TNK2 ACK1_HUMAN 1U54A 2.8 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai ACP ATPlike 115 - 390 0 PTR284 None Activated CDC42 kinase 1
TYR TNK2 ACK1_HUMAN 1U54B 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 117 - 388 0 None None Activated CDC42 kinase 1

Ligand: ACP

Total number of chains: 100
Active chains: 11
Total number of genes: 24
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 68 68.0% 4F0FA
DFGin BLBplus 10 10.0% 4ANBA
DFGin ABAminus 7 7.0% 5X1SA
DFGin BLBminus 5 5.0% 7KJCA
DFGin None 3 3.0% 4C3PA
None None 3 3.0% 6I2PA
DFGin BLAplus 2 2.0% 6PNXB
DFGinter None 2 2.0% 4C3RA
All chains - renumbered by
Uniprot PDB Alignment
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Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL ROCO4 ROCO4_DICDI 4F0FA 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iioo ACP ATPlike 1019 - 1292 0 None None Probable serine/threonine-protein kinase roco4 Dictyostelium discoideum
TKL ROCO4 ROCO4_DICDI 4F1OA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iioo ACP ATPlike 1019 - 1292 0 None None Probable serine/threonine-protein kinase roco4 Dictyostelium discoideum
TKL ROCO4 ROCO4_DICDI 4F1MA 2.04 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iioo ACP, BTB ATPlike, Allosteric 1019 - 1292 0 None G1179S Probable serine/threonine-protein kinase roco4 Dictyostelium discoideum
AGC PRKCI KPCI_HUMAN 5LI9A 1.79 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 248 - 589 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7QA 2.0 Inactive DFGin‑BLBplus none-none out-out nonTYR APEdihe_aaiii APEdist_nnno ACP ATPlike 56 - 340 0 None None Ribosomal protein S6 kinase alpha-1 Homo sapiens
CAMK AURKA AURKA_HUMAN 4C3PD 2.69 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaooi APEdist_nooo ACP ATPlike 125 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5G15A 2.06 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 126 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6CPFA 2.3 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 128 - 392 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4C3PA 2.69 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaooi APEdist_oooo ACP ATPlike 125 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4C3RA 2.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6C83B 2.55 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6C83A 2.55 Inactive None‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 389 0 None None Aurora kinase A Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3ZXTB 2.65 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn ACP ATPlike 7 - 276 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3ZXTC 2.65 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ACP ATPlike 5 - 276 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3ZXTD 2.65 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn ACP ATPlike 7 - 276 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3ZXTA 2.65 Inactive DFGin‑BLBminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ACP ATPlike 7 - 276 0 None None Death-associated protein kinase 1 Homo sapiens
CK1 CSNK1D KC1D_HUMAN 6RU6A 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 3 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 6RU6B 2.05 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ACP ATPlike 3 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 4NH1A 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ACP ATPlike 3 - 332 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 4NH1B 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ACP ATPlike 2 - 333 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC MAPK1 MK01_HUMAN 5V60A 2.18 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 10 - 358 0 TPO185,PTR187 None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK10 MK10_HUMAN 6EQ9B 1.83 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno ACP ATPlike 47 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 6EQ9A 1.83 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_nnno ACP, C15 ATPlike, Allosteric 46 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 8VTFA 2.4 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaiii APEdist_oooo A1ACP Type1 45 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
OTHER RNASEL RN5A_HUMAN 4OAVB 2.1 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ACP ATPlike 24 - 717 0 None H672N 2-5A-dependent ribonuclease Homo sapiens
OTHER RNASEL RN5A_HUMAN 4OAVD 2.1 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ACP ATPlike 26 - 719 0 None H672N 2-5A-dependent ribonuclease Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6U2GA 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNEA 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 63 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNED 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 66 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4AN9A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onoo ACP, 2P7 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNEE 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNEH 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ACP, 573, 573 ATPlike, Type3, Allosteric 66 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4AN2A 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo EUI, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4ANBA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YQY, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
TKL BRAF BRAF_HUMAN 6U2GB 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ACP ATPlike 451 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5NG0A 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 6 - 300 0 None L294F Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5NG0B 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii ACP ATPlike 5 - 299 0 None L294F Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5AR3A 3.23 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ACP ATPlike 6 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5AR3B 3.23 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn ACP ATPlike 6 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 7KJAB 1.75 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ACP ATPlike 590 - 965 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 7KJCA 2.3 Inactive DFGin‑BLBminus in-in out-none TYR APEdihe_niiai APEdist_aaai ACP ATPlike 590 - 976 0 None S901E Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 7KJCB 2.3 Inactive DFGin‑BLBminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ACP ATPlike 590 - 965 0 None S901E Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 7KJAA 1.75 Inactive DFGin‑BLBminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ACP ATPlike 590 - 976 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 3GQIA 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 464 - 770 0 PTR653,PTR654,PTR766 C488A,Y583F,C584S,Y585F Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PWLA 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,N549H Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PWLB 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 765 0 None C491A,N549H Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J96B 2.297 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 462 - 766 0 None C491A,K659M Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J98B 2.307 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 461 - 764 0 None C491A,K659Q Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PVFA 1.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 467 - 765 0 PTR586,PTR656,PTR657 C491A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 3CLYA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 468 - 772 0 PTR656,PTR657 C491A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J99A 1.847 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 466 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J99B 1.847 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J99C 1.847 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J99D 1.847 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 465 - 764 0 None C491A,K659T Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PVYA 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PVYB 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 462 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PVYC 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 462 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PVYD 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J95A 2.377 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J95B 2.377 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J95C 2.377 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J95D 2.377 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659N Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PZ5A 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,N549T Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PZ5B 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,N549T Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J97A 2.548 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J97B 2.548 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J97C 2.548 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 4J97D 2.548 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 466 - 764 0 None C491A,K659E Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PZPA 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,K526E Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PZPB 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,K526E Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PZRA 3.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 765 0 None C491A,K641R Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PZRB 3.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 766 0 None C491A,K641R Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 5UHNA 2.909 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 469 - 764 0 None N549H,E565A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 5UHNB 2.909 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 469 - 764 0 None N549H,E565A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 5UGXA 2.349 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,E565A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 5UGXB 2.349 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 764 0 None C491A,E565A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 5UI0B 2.05 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 462 - 765 0 None C491A,E565A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2Q0BA 2.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 765 0 None C491A,E565A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2Q0BB 2.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,E565A Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PY3A 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,E565G Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 2PY3B 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 468 - 766 0 None C491A,E565G Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 5EG3A 2.606 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 466 - 774 0 PTR769 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 6V6QA 2.46 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 466 - 765 0 PTR656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 6V6QB 2.46 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 766 0 PTR656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 6V6QD 2.46 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 765 0 PTR656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 6V6QC 2.46 Inactive DFGin‑BLBminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 467 - 766 0 PTR656 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR3 FGFR3_HUMAN 4K33A 2.341 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 459 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3 Homo sapiens
TYR FGFR3 FGFR3_HUMAN 6PNXA 2.199 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 456 - 757 0 None C482A,C582S,R669E Fibroblast growth factor receptor 3 Homo sapiens
TYR FGFR3 FGFR3_HUMAN 6PNXB 2.199 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 455 - 756 0 None C482A,C582S,R669E Fibroblast growth factor receptor 3 Homo sapiens
TYR IGF1R IGF1R_HUMAN 1K3AA 2.1 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 988 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR INSR INSR_HUMAN 4XLVA 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 1001 - 1310 0 PTR999,PTR1185,PTR1189,PTR1190 Y992F,C1008S Insulin receptor Homo sapiens
TYR INSR INSR_HUMAN 1I44A 2.4 Inactive DFGin‑None in-out none-out TYR APEdihe_nnoai APEdist_aaai ACP ATPlike 1013 - 1310 0 None C1008S,Y1011F,D1188A Insulin receptor Homo sapiens
TYR TNK2 ACK1_HUMAN 1U54A 2.8 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai ACP ATPlike 115 - 390 0 PTR284 None Activated CDC42 kinase 1 Homo sapiens
TYR TNK2 ACK1_HUMAN 1U54B 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 117 - 388 0 None None Activated CDC42 kinase 1 Homo sapiens
AGC PRKACA KAPCA_MOUSE 4IACA 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
CMGC MAPK14 MK14_MOUSE 8VMMA 2.4 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo A1ACP Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
OTHER PKNB PKNB_MYCTU 1O6YA 2.2 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ACP ATPlike 3 - 278 0 None None Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 6I2PA 2.37 Inactive None‑None in-out out-out nonTYR APEdihe_aaooo APEdist_iooo ACP ATPlike 1 - 278 0 TPO171,TPO173 L33E Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 6I2PB 2.37 Inactive None‑None in-out none-out nonTYR APEdihe_aanno APEdist_onnn ACP ATPlike 2 - 277 0 TPO171,TPO173 L33E Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER None A0ACD6BAW3_SERSF 5X1SA 1.45 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiai APEdist_oioo ACP ATPlike 11 - 296 0 None None PpkA N terminal Serratia sp.

Ligand: ACP

Total number of chains: 9
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 55.6% 4F0FA
None None 2 22.2% 6I2PA
DFGin ABAminus 1 11.1% 5X1SA
DFGin None 1 11.1% 8VMMA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL ROCO4 ROCO4_DICDI 4F0FA 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iioo ACP ATPlike 1019 - 1292 0 None None Probable serine/threonine-protein kinase roco4 Dictyostelium discoideum
TKL ROCO4 ROCO4_DICDI 4F1OA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iioo ACP ATPlike 1019 - 1292 0 None None Probable serine/threonine-protein kinase roco4 Dictyostelium discoideum
TKL ROCO4 ROCO4_DICDI 4F1MA 2.04 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iioo ACP, BTB ATPlike, Allosteric 1019 - 1292 0 None G1179S Probable serine/threonine-protein kinase roco4 Dictyostelium discoideum
AGC PRKACA KAPCA_MOUSE 4IACA 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
CMGC MAPK14 MK14_MOUSE 8VMMA 2.4 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo A1ACP Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus
OTHER PKNB PKNB_MYCTU 1O6YA 2.2 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ACP ATPlike 3 - 278 0 None None Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 6I2PA 2.37 Inactive None‑None in-out out-out nonTYR APEdihe_aaooo APEdist_iooo ACP ATPlike 1 - 278 0 TPO171,TPO173 L33E Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 6I2PB 2.37 Inactive None‑None in-out none-out nonTYR APEdihe_aanno APEdist_onnn ACP ATPlike 2 - 277 0 TPO171,TPO173 L33E Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER None A0ACD6BAW3_SERSF 5X1SA 1.45 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiai APEdist_oioo ACP ATPlike 11 - 296 0 None None PpkA N terminal Serratia sp.