TYR_TNK2 (Activated CDC42 kinase 1)

Total number of chains: 32
Active chains: 6
Uniprot: ACK1_HUMAN
Kinase Domain Residues: 126 - 387
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 16 50.0% 4EWHA
DFGin BLAminus 9 28.1% AF-Q07912-K1A
DFGin BLBplus 4 12.5% 4HZSA
DFGout None 2 6.2% 5ZXBB
DFGin None 1 3.1% 8HMTD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
1U54B 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 117 - 388 0 None None Activated CDC42 kinase 1
AF-Q07912-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 118 - 395 0 None None Activated CDC42 kinase 1
AF-Q07912-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 118 - 395 0 None None Activated CDC42 kinase 1
1U46B 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 117 - 390 0 None None Activated CDC42 kinase 1
6VQMB 2.87 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R7P Type1 117 - 392 0 None None Activated CDC42 kinase 1
1U4DB 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai DBQ Type1 117 - 390 0 None None Activated CDC42 kinase 1
1U54A 2.8 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai ACP ATPlike 115 - 390 0 PTR284 None Activated CDC42 kinase 1
4HZRA 1.31 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 117 - 389 0 None None Activated CDC42 kinase 1
4HZRB 1.31 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 118 - 389 0 None None Activated CDC42 kinase 1
1U46A 2.0 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 117 - 389 0 None None Activated CDC42 kinase 1
4EWHA 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai T77 Type1 117 - 391 0 PTR284 None Activated CDC42 kinase 1
4EWHB 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai T77 Type1 117 - 390 0 PTR284 None Activated CDC42 kinase 1
7KP6A 1.79 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai WTP Type1 117 - 391 0 None None Activated CDC42 kinase 1
7KP6B 1.79 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai WTP Type1 117 - 391 0 None None Activated CDC42 kinase 1
6VQMA 2.87 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R7P Type1 117 - 390 0 None None Activated CDC42 kinase 1
8FE9A 3.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WTP Type1 117 - 390 0 None K161Q Activated CDC42 kinase 1
4ID7A 3.0 Inactive DFGin‑ABAminus out-out in-in TYR APEdihe_iiiai APEdist_aaai 1G0 Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1
8HMTA 3.17 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1
8HMTB 3.17 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 388 0 None None Activated CDC42 kinase 1
8HMTC 3.17 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1
3EQRA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai T74 Type1.5_Back 117 - 392 0 None None Activated CDC42 kinase 1
3EQRB 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai T74 Type1.5_Back 117 - 390 0 None None Activated CDC42 kinase 1
3EQPA 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai T95 Type1 117 - 390 0 None None Activated CDC42 kinase 1
3EQPB 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai T95 Type1 117 - 392 0 None None Activated CDC42 kinase 1
4HZSA 3.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 115 - 446 0 None None Activated CDC42 kinase 1
4HZSB 3.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 115 - 446 0 None None Activated CDC42 kinase 1
4HZSC 3.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 115 - 446 0 None None Activated CDC42 kinase 1
4HZSD 3.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 115 - 446 0 None None Activated CDC42 kinase 1
8HMTD 3.17 Inactive DFGin‑None in-out in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1
5ZXBA 2.198 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 9KO Type2 117 - 389 0 None None Activated CDC42 kinase 1
5ZXBB 2.198 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 9KO Type2 117 - 389 0 None None Activated CDC42 kinase 1
1U4DA 2.1 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai DBQ Type1 117 - 389 0 None None Activated CDC42 kinase 1

TYR_TNK2 (Activated CDC42 kinase 1)

Total number of chains: 32
Active chains: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 16 50.0% 4EWHA
DFGin BLAminus 9 28.1% AF-Q07912-K1A
DFGin BLBplus 4 12.5% 4HZSA
DFGout None 2 6.2% 5ZXBB
DFGin None 1 3.1% 8HMTD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ACK1_HUMAN 1U54B 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 117 - 388 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN AF-Q07912-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 118 - 395 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN AF-Q07912-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 118 - 395 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 1U46B 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 117 - 390 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 6VQMB 2.87 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R7P Type1 117 - 392 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 1U4DB 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai DBQ Type1 117 - 390 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 1U54A 2.8 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai ACP ATPlike 115 - 390 0 PTR284 None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4HZRA 1.31 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4HZRB 1.31 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 118 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 1U46A 2.0 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4EWHA 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai T77 Type1 117 - 391 0 PTR284 None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4EWHB 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai T77 Type1 117 - 390 0 PTR284 None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 7KP6A 1.79 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai WTP Type1 117 - 391 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 7KP6B 1.79 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai WTP Type1 117 - 391 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 6VQMA 2.87 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R7P Type1 117 - 390 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 8FE9A 3.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WTP Type1 117 - 390 0 None K161Q Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4ID7A 3.0 Inactive DFGin‑ABAminus out-out in-in TYR APEdihe_iiiai APEdist_aaai 1G0 Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 8HMTA 3.17 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 8HMTB 3.17 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 388 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 8HMTC 3.17 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 3EQRA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai T74 Type1.5_Back 117 - 392 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 3EQRB 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai T74 Type1.5_Back 117 - 390 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 3EQPA 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai T95 Type1 117 - 390 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 3EQPB 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai T95 Type1 117 - 392 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4HZSA 3.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 115 - 446 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4HZSB 3.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 115 - 446 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4HZSC 3.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 115 - 446 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 4HZSD 3.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 115 - 446 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 8HMTD 3.17 Inactive DFGin‑None in-out in-in TYR APEdihe_iiiai APEdist_aaai LWX Type1.5_Back 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 5ZXBA 2.198 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 9KO Type2 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 5ZXBB 2.198 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 9KO Type2 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
ACK1_HUMAN 1U4DA 2.1 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai DBQ Type1 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens

TYR_TNK2 (Activated CDC42 kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism