Ligand: ADP

Total number of chains: 206
Active chains: 71
Total number of genes: 47
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 161 78.2% 6YZHA
DFGin BLBplus 17 8.3% 4M15A
DFGin None 13 6.3% 4RIYD
DFGin ABAminus 5 2.4% 3LCTA
DFGinter None 4 1.9% 5L8LA
DFGin BLBminus 3 1.5% 8PR7D
None None 3 1.5% 2W5AA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC CDC42BPB MRCKB_HUMAN 4UAKA 1.73 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 417 0 None None Serine/threonine-protein kinase MRCK beta
AGC PRKCI KPCI_HUMAN 5LIHA 3.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 248 - 588 0 TPO412,TPO564 None Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LIHB 3.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJMB 3.33 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
CAMK AURKA AURKA_HUMAN 8GUWA 2.7 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno ADP ATPlike 506 - 388 0 None C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWB 2.7 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aanoo APEdist_nnnn ADP ATPlike 507 - 390 0 None C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWC 2.7 Inactive DFGin‑ABAminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 506 - 388 0 None C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 4BN1A 2.499 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 126 - 388 0 TPO287,TPO288 V174M Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MQ4A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 126 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL5A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 123 - 388 0 TPO287,TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL7A 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 127 - 390 0 TPO287,TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DEEA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 124 - 394 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 5LXMA 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 4CEGA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G1XA 1.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORLA 1.69 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A4W ATPlike, Allosteric 127 - 391 0 TPO288 C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORNA 2.19 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OROA 2.12 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORPA 2.19 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5K ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORRA 2.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5Q ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORSA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5W ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORTA 2.56 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5Z ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORVA 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A65 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORWA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORXA 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORYA 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, AY4 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORZA 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6W ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS0A 1.74 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6Z ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS1A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS2A 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ADP, A7K ATPlike, Allosteric 127 - 391 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS3A 1.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7N ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS4A 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A8H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS6A 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7Q ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSEA 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A98 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSFA 1.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A9E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSDA 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A9B ATPlike, Allosteric 125 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS5A 1.74 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A8K ATPlike, Allosteric 125 - 392 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R49A 2.209 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, JSB ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4AA 1.937 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRT ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4BA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JSN ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4CA 2.04 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRQ ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4DA 2.009 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRW ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 7ZTLA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, BCN ATPlike, Allosteric 126 - 389 0 TPO288 C290A,K339C,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8OF5A 1.97 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo ADP, MPO ATPlike, Allosteric 126 - 390 0 None C290A,N332A,Q335A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C14A 1.93 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ADP, T5L, T0L ATPlike, Allosteric, Allosteric 126 - 389 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C15A 2.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T4C, T5L ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1FA 1.924 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T5L, T2O ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1IA 2.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T1L, T5L ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1MA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo T4X, ADP Allosteric, ATPlike 127 - 389 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1DA 2.115 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T2F, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1GA 1.96 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T3I, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1HA 2.233 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T3U, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1KA 2.43 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo T4O, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7D 2.76 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 388 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ODTA 2.021 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 392 0 None D274N,C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA 2.1 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aaiii APEdist_nnni ADP, AMP ATPlike, Allosteric 124 - 391 0 None C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8JA 1.68 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 126 - 391 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8KA 1.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8LA 1.67 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7A 2.76 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ADP ATPlike 124 - 389 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WQEA 2.5 Inactive None‑None out-none none-out nonTYR APEdihe_aaoii APEdist_nnno ADP, ADP, ADP ATPlike, ATPlike, ATPlike 127 - 388 0 None S155R Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 7UJSA 2.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 7 - 274 0 None Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPA 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 7 - 274 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK2 CHK2_HUMAN 2CN5A 2.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaooi APEdist_oooo ADP ATPlike 209 - 504 0 None None Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 2W4JA 1.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EH9A 1.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5GA 1.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2W4KA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 302 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU6A 1.49 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None Q23V Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU7A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None Q23V Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2XUUA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 302 0 None E182A Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 1NY3A 3.0 Inactive DFGin‑BLAminus out-out in-none nonTYR APEdihe_aannn APEdist_nnnn ADP ATPlike 46 - 345 0 None None MAP kinase-activated protein kinase 2
CAMK PASK PASK_HUMAN 3DLSA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1266 0 None None PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1267 0 None None PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1267 0 None None PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1266 0 None None PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSE 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1267 0 None None PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSF 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1266 0 None None PAS domain-containing serine/threonine-protein kinase
CAMK STK17B ST17B_HUMAN 6QF4A 2.495 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nioo ADP ATPlike 18 - 308 0 None None Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7CA 2.85 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 25 - 297 0 None None Serine/threonine-protein kinase 17B
CK1 CSNK1D KC1D_HUMAN 6RU7A 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 3 - 294 0 None None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU7B 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 3 - 294 0 None None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8A 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 2 - 294 0 None None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8B 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 2 - 294 0 None None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8C 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 2 - 294 0 None None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8D 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 2 - 294 0 None None Casein kinase I isoform delta
CK1 TTBK1 TTBK1_HUMAN 4BTJA 2.16 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 21 - 312 0 None None Tau-tubulin kinase 1
CK1 TTBK2 TTBK2_HUMAN 6VRFA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 9 - 298 0 None None Tau-tubulin kinase 2
CK1 TTBK2 TTBK2_HUMAN 6VRFB 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 9 - 298 0 None None Tau-tubulin kinase 2
CMGC CDK11B CD11B_HUMAN 9I9IK 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 440 - 740 0 TPO595 None Cyclin-dependent kinase 11B
CMGC CDK12 CDK12_HUMAN 4NSTA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 716 - 1046 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4NSTC 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 717 - 1045 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK13 CDK13_HUMAN 5EFQA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 695 - 1025 0 TPO871 None Cyclin-dependent kinase 13
CMGC CDK13 CDK13_HUMAN 5EFQC 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 697 - 1031 0 TPO871 None Cyclin-dependent kinase 13
CMGC CDK2 CDK2_HUMAN 4I3ZA 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4I3ZC 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRA 2.17 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRC 2.17 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWA 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWC 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5A 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5C 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9JK 3.1 Inactive DFGin‑BLAminus in-out none-out nonTYR APEdihe_aaooi APEdist_nnno ADP ATPlike 6 - 284 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9KK 2.4 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 2 - 292 0 None None Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 9I9IJ 3.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 12 - 310 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9JJ 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ADP ATPlike 11 - 310 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9KJ 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ADP ATPlike 10 - 310 0 None None Cyclin-dependent kinase 7
CMGC CSNK2A1 CSK21_HUMAN 6Z19B 1.47 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 329 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUB 2.324 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKB 2.143 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 4 - 326 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7QUXA 1.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 329 0 SEP2 None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YZHA 1.19 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 3 - 329 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YPNB 1.58 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, ADP ATPlike, Allosteric 2 - 327 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHA 1.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP ATPlike, Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHB 1.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP ATPlike, Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8A 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, RKN ATPlike, Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8B 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, RKN ATPlike, Allosteric 3 - 325 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJB 1.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A4Q ATPlike, Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKA 2.143 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A4T ATPlike, Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYKA 1.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, KEC ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MPJA 2.14 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP, J2P ATPlike, Allosteric, Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUA 2.324 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A4B, IHP ATPlike, Allosteric, Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSLA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A9K, A9K ATPlike, Allosteric, Allosteric 2 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEB 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP, OQC, OQC ATPlike, Allosteric, Allosteric, Allosteric 4 - 326 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJA 1.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A4Q, A4Q, IHP ATPlike, Allosteric, Allosteric, Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEA 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP, OQC, OQC, OQC ATPlike, Allosteric, Allosteric, Allosteric, Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY0A 1.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KC0, ADP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AE7A 1.28 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LVU, ADP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8IA 1.47 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BZ5, ADP Type1, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8LA 1.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1B0I, ADP Type1, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8QA 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BZU, ADP Type1, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC GSK3B GSK3B_HUMAN 4NM5A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 24 - 383 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM7A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 25 - 383 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM0A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 26 - 383 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM3A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 6 - 383 0 SEP9 None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 35 - 388 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 23 - 386 0 None None Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4IZ5A 3.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 11 - 357 0 None T185E Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5B 3.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 11 - 357 0 None T185E Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5C 3.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 11 - 357 0 None T185E Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5D 3.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 11 - 357 0 None T185E Mitogen-activated protein kinase 1
CMGC PRP4K PRP4K_HUMAN 4IFCA 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi ADP ATPlike 668 - 1005 0 PTR849 None Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IFCB 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi ADP ATPlike 670 - 1005 0 PTR849 None Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 1WBPA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 67 - 655 0 None None SRSF protein kinase 1
NEK NEK2 NEK2_HUMAN 2W5AA 1.55 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ADP ATPlike 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 9NFQC 3.25 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo ADP ATPlike 20 - 300 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQNA 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ADP ATPlike 21 - 300 0 None None Serine/threonine-protein kinase Nek7
OTHER BUB1 BUB1_HUMAN 4QPMA 2.202 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 740 - 1083 0 SEP969 None Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4QPMB 2.202 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 740 - 1081 0 SEP969 None Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4R8QA 2.31 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_iooo ADP ATPlike 736 - 1083 0 None None Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZA 2.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaoio APEdist_iooi ADP ATPlike 735 - 1083 0 SEP969 None Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZB 2.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaoio APEdist_iooi ADP ATPlike 735 - 1083 0 SEP969 None Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER CDC7 CDC7_HUMAN 4F99A 2.33 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnnn ADP ATPlike 41 - 572 0 None None Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA 2.17 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnnn ADP ATPlike 39 - 572 0 None None Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC 2.17 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnnn ADP ATPlike 37 - 572 0 None None Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A 1.67 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ADP ATPlike 39 - 573 0 None None Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A 1.79 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ADP, BEF ATPlike, Allosteric 38 - 572 0 None None Cell division cycle 7-related protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoo APEdist_nnnn ADP ATPlike 256 - 544 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanio APEdist_nnnn ADP ATPlike 255 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KC 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP ATPlike 257 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
OTHER ERN1 ERN1_HUMAN 4YZDA 3.102 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDB 3.102 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_niii ADP ATPlike 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDC 3.102 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_niii ADP ATPlike 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23B 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoi ADP ATPlike 564 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23C 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_iioi ADP ATPlike 561 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23D 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_nnoi ADP ATPlike 561 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER PIK3R4 PI3R4_HUMAN 8SORA 3.96 Pseudo DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaoao APEdist_oooo ADP ATPlike 15 - 1358 0 None None Phosphoinositide 3-kinase regulatory subunit 4
OTHER RNASEL RN5A_HUMAN 4OAUC 2.6 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ADP ATPlike 25 - 719 0 None H672N 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 3EQIA 1.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3MBLA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LSG ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ARKA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, M3K ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQGA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP, 4BM ATPlike, Type3 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6NYBB 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LCJ ATPlike, Type3 56 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 5BM, ADP Type3, ATPlike 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE PAK3 PAK3_HUMAN 6FD3A 1.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 261 - 556 0 None A537D Serine/threonine-protein kinase PAK 3
STE STK24 STK24_HUMAN 3A7JA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4O27B 3.185 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 30 - 309 0 None T190E Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 8VSUB 2.86 Pseudo DFGin‑None out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ADP ATPlike 60 - 401 0 None None STE20-related kinase adapter protein alpha
STE TAOK3 TAOK3_HUMAN 6BDNA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 8 - 314 0 None R2A,K3A Serine/threonine-protein kinase TAO3
TKL BMPR2 BMPR2_HUMAN 3G2FA 2.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 197 - 510 0 None None Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 3G2FB 2.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 198 - 513 0 None None Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 197 - 509 0 None D485G Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPA 2.3 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_niii ADP, ADP ATPlike, Allosteric 199 - 509 0 None D485G Bone morphogenetic protein receptor type-2
TKL KSR2 KSR2_HUMAN 7JUQB 3.22 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ADP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2
TYR ABL1 ABL1_HUMAN 2G2IA 3.12 Inactive DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 229 - 502 0 None H396P Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2IB 3.12 Inactive DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 232 - 500 0 None H396P Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 3LCTA 2.1 Inactive DFGin‑ABAminus in-none out-out TYR APEdihe_oiiai APEdist_aaao ADP ATPlike 1093 - 1400 0 None S1281G ALK tyrosine kinase receptor
TYR EGFR EGFR_HUMAN 4RIWB 3.1 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIWD 3.1 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXB 3.1 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXD 3.1 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYB 2.981 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYD 2.981 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor
TYR EPHB1 EPHB1_HUMAN 7KPMA 1.608 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 611 - 888 0 PTR647 None Ephrin type-B receptor 1
TYR ITK ITK_HUMAN 4M15A 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao QWS, ADP Type3, ATPlike 355 - 617 0 None None Tyrosine-protein kinase ITK/TSK
TYR JAK1-2 JAK1_HUMAN 5KHWA 2.47 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 867 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 6C7YA 2.499 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 869 - 1153 0 PTR1035 None Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 5KHWB 2.47 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 867 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
TYR KIT KIT_HUMAN 1PKGA 2.9 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 567 - 927 0 PTR568,PTR570 None Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 1PKGB 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai ADP ATPlike 566 - 929 0 PTR568,PTR570 None Mast/stem cell growth factor receptor Kit
TYR MERTK MERTK_HUMAN 3BRBA 1.9 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ADP ATPlike 575 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3BRBB 1.9 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 575 - 863 0 None None Tyrosine-protein kinase Mer
TYR PTK2 FAK1_HUMAN 2IJMB 2.187 Inactive DFGin‑BLBminus in-out none-out TYR APEdihe_nnoai APEdist_aaao ADP ATPlike 414 - 689 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 1MP8A 1.6 Inactive None‑None in-in none-out TYR APEdihe_nniai APEdist_aaao ADP ATPlike 414 - 686 0 None None Focal adhesion kinase 1
TYR TYK2-2 TYK2_HUMAN 4GVJA 2.03 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 889 - 1176 0 None C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2

Ligand: ADP

Total number of chains: 317
Active chains: 117
Total number of genes: 75
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 239 75.4% 6YZHA
DFGin BLBplus 31 9.8% 4M15A
DFGin None 17 5.4% 5GZAA
None None 11 3.5% 4IX4A
DFGin ABAminus 10 3.2% 3LCTA
DFGin BLBminus 5 1.6% 5M06B
DFGinter None 4 1.3% 5L8LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL BRI1 BRI1_ARATH 5LPBA 1.98 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 T872A Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 5LPZA 2.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 866 - 1160 0 TPO1039,SEP1042,SEP1044 T872A Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDXA 2.23 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDXB 2.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDYA 2.28 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDYB 2.28 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 522 - 816 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDWA 1.926 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDWB 1.926 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 522 - 816 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
AGC GRK1 GRK1_BOVIN 3C4ZA 1.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C50A 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 30 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C50B 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 30 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C51A 3.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C51B 3.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3QC9A 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None T8C,N480C Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3QC9B 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None T8C,N480C Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3QC9C 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None T8C,N480C Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3QC9D 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None T8C,N480C Rhodopsin kinase GRK1 Bos taurus
CK1 HRR25 Q6FS46_CANGA 4XH0A 1.99 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 3 - 397 0 None K38R non-specific serine/threonine protein kinase Candida glabrata
CK1 HRR25 Q6FS46_CANGA 4XHGA 2.15 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iioo ADP ATPlike 2 - 397 0 None K38R non-specific serine/threonine protein kinase Candida glabrata
AGC PRKACA KAPCA_CRIGR 6EM6A 1.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 6EM7A 1.238 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
CMGC CDK Q5CRJ8_CRYPI 3NIZA 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 1 - 293 0 None None Cyclin-dependent kinase 2 homolog Cryptosporidium parvum
CAMK PLK1 Q4KMI8_DANRE 3D5WA 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 24 - 310 0 TPO196 None Serine/threonine-protein kinase PLK Danio rerio
OTHER POMK SG196_DANRE 5GZAA 2.0 Pseudo DFGin‑None none-na in-out nonTYR APEdihe_aaioo APEdist_iioo ADP, ZZ1 ATPlike, Allosteric 53 - 342 0 None None Protein O-mannose kinase Danio rerio
CAMK CAMKII KCC2A_DROME 5FG8A 1.955 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 7 - 275 0 None None Calcium/calmodulin-dependent protein kinase type II alpha chain Drosophila melanogaster
CAMK CAMKII KCC2A_DROME 5HU3A 1.885 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 7 - 272 0 None D136N Calcium/calmodulin-dependent protein kinase type II alpha chain Drosophila melanogaster
CAMK OBSCN-1 OBSCN_DROME 8AK3A 1.9 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ADP ATPlike 3186 - 3477 0 None None Protein Obscurin Drosophila melanogaster
OTHER BUBR1 A1Z6I7_DROME 6JKMA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iooo ADP ATPlike 1127 - 1459 0 None None Bub1-related kinase Drosophila melanogaster
CAMK CDPK Q3HNM4_EIMTE 4YSJA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 26 - 499 0 None None non-specific serine/threonine protein kinase Eimeria tenella
CAMK CDPK Q3HNM4_EIMTE 4YSJB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 26 - 499 0 None None non-specific serine/threonine protein kinase Eimeria tenella
AGC CDC42BPB MRCKB_HUMAN 4UAKA 1.73 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 417 0 None None Serine/threonine-protein kinase MRCK beta Homo sapiens
AGC PRKCI KPCI_HUMAN 5LIHA 3.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 248 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
AGC PRKCI KPCI_HUMAN 5LIHB 3.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
AGC PRKCI KPCI_HUMAN 9EJMB 3.33 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
CAMK AURKA AURKA_HUMAN 8GUWA 2.7 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno ADP ATPlike 506 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8GUWB 2.7 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aanoo APEdist_nnnn ADP ATPlike 507 - 390 0 None C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8GUWC 2.7 Inactive DFGin‑ABAminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 506 - 388 0 None C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4BN1A 2.499 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 126 - 388 0 TPO287,TPO288 V174M Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 1MQ4A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 1OL5A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 123 - 388 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 1OL7A 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 127 - 390 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4DEEA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 124 - 394 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5LXMA 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4CEGA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5G1XA 1.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORLA 1.69 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A4W ATPlike, Allosteric 127 - 391 0 TPO288 C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORNA 2.19 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OROA 2.12 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORPA 2.19 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5K ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORRA 2.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5Q ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORSA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5W ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORTA 2.56 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A5Z ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORVA 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A65 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORWA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORXA 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORYA 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, AY4 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ORZA 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6W ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OS0A 1.74 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A6Z ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OS1A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OS2A 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo ADP, A7K ATPlike, Allosteric 127 - 391 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OS3A 1.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7N ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OS4A 1.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A8H ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OS6A 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A7Q ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OSEA 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A98 ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OSFA 1.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A9E ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OSDA 1.99 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A9B ATPlike, Allosteric 125 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5OS5A 1.74 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, A8K ATPlike, Allosteric 125 - 392 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6R49A 2.209 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, JSB ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6R4AA 1.937 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRT ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6R4BA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JSN ATPlike, Allosteric 127 - 391 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6R4CA 2.04 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRQ ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6R4DA 2.009 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP, JRW ATPlike, Allosteric 127 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 7ZTLA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, BCN ATPlike, Allosteric 126 - 389 0 TPO288 C290A,K339C,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8OF5A 1.97 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo ADP, MPO ATPlike, Allosteric 126 - 390 0 None C290A,N332A,Q335A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C14A 1.93 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ADP, T5L, T0L ATPlike, Allosteric, Allosteric 126 - 389 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C15A 2.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T4C, T5L ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1FA 1.924 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T5L, T2O ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1IA 2.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP, T1L, T5L ATPlike, Allosteric, Allosteric 126 - 388 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1MA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo T4X, ADP Allosteric, ATPlike 127 - 389 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1DA 2.115 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T2F, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1GA 1.96 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T3I, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1HA 2.233 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T3U, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1KA 2.43 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo T4O, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8PR7D 2.76 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 388 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5ODTA 2.021 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnoo ADP ATPlike 126 - 392 0 None D274N,C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 9GUCA 2.1 Inactive DFGin‑None out-none none-none nonTYR APEdihe_aaiii APEdist_nnni ADP, AMP ATPlike, Allosteric 124 - 391 0 None C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5L8JA 1.68 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 126 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5L8KA 1.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5L8LA 1.67 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8PR7A 2.76 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ADP ATPlike 124 - 389 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2WQEA 2.5 Inactive None‑None out-none none-out nonTYR APEdihe_aaoii APEdist_nnno ADP, ADP, ADP ATPlike, ATPlike, ATPlike 127 - 388 0 None S155R Aurora kinase A Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 7UJSA 2.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 7 - 274 0 None Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 7UJPA 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 7 - 274 0 None D135N,Q223K Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CHEK2 CHK2_HUMAN 2CN5A 2.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaooi APEdist_oooo ADP ATPlike 209 - 504 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 2W4JA 1.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3EH9A 1.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3F5GA 1.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 2W4KA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 302 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3GU6A 1.49 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None Q23V Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3GU7A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 2 - 277 0 None Q23V Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 2XUUA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 302 0 None E182A Death-associated protein kinase 1 Homo sapiens
CAMK MAPKAPK2 MAPK2_HUMAN 1NY3A 3.0 Inactive DFGin‑BLAminus out-out in-none nonTYR APEdihe_aannn APEdist_nnnn ADP ATPlike 46 - 345 0 None None MAP kinase-activated protein kinase 2 Homo sapiens
CAMK PASK PASK_HUMAN 3DLSA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1266 0 None None PAS domain-containing serine/threonine-protein kinase Homo sapiens
CAMK PASK PASK_HUMAN 3DLSB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1267 0 None None PAS domain-containing serine/threonine-protein kinase Homo sapiens
CAMK PASK PASK_HUMAN 3DLSC 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1267 0 None None PAS domain-containing serine/threonine-protein kinase Homo sapiens
CAMK PASK PASK_HUMAN 3DLSD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1266 0 None None PAS domain-containing serine/threonine-protein kinase Homo sapiens
CAMK PASK PASK_HUMAN 3DLSE 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1267 0 None None PAS domain-containing serine/threonine-protein kinase Homo sapiens
CAMK PASK PASK_HUMAN 3DLSF 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 982 - 1266 0 None None PAS domain-containing serine/threonine-protein kinase Homo sapiens
CAMK STK17B ST17B_HUMAN 6QF4A 2.495 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nioo ADP ATPlike 18 - 308 0 None None Serine/threonine-protein kinase 17B Homo sapiens
CAMK STK17B ST17B_HUMAN 7Q7CA 2.85 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 25 - 297 0 None None Serine/threonine-protein kinase 17B Homo sapiens
CK1 CSNK1D KC1D_HUMAN 6RU7A 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 3 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 6RU7B 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 3 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 6RU8A 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 2 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 6RU8B 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 2 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 6RU8C 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 2 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 6RU8D 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 2 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CK1 TTBK1 TTBK1_HUMAN 4BTJA 2.16 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 21 - 312 0 None None Tau-tubulin kinase 1 Homo sapiens
CK1 TTBK2 TTBK2_HUMAN 6VRFA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 9 - 298 0 None None Tau-tubulin kinase 2 Homo sapiens
CK1 TTBK2 TTBK2_HUMAN 6VRFB 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 9 - 298 0 None None Tau-tubulin kinase 2 Homo sapiens
CMGC CDK11B CD11B_HUMAN 9I9IK 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 440 - 740 0 TPO595 None Cyclin-dependent kinase 11B Homo sapiens
CMGC CDK12 CDK12_HUMAN 4NSTA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 716 - 1046 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 4NSTC 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 717 - 1045 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK13 CDK13_HUMAN 5EFQA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 695 - 1025 0 TPO871 None Cyclin-dependent kinase 13 Homo sapiens
CMGC CDK13 CDK13_HUMAN 5EFQC 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 697 - 1031 0 TPO871 None Cyclin-dependent kinase 13 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4I3ZA 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4I3ZC 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3QHRA 2.17 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3QHRC 2.17 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3QHWA 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3QHWC 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4II5A 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4II5C 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 9I9JK 3.1 Inactive DFGin‑BLAminus in-out none-out nonTYR APEdihe_aaooi APEdist_nnno ADP ATPlike 6 - 284 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 9I9KK 2.4 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 2 - 292 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK7 CDK7_HUMAN 9I9IJ 3.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 12 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 9I9JJ 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ADP ATPlike 11 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 9I9KJ 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ADP ATPlike 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6Z19B 1.47 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 329 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OQUB 2.324 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5ORKB 2.143 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 4 - 326 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7QUXA 1.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 329 0 SEP2 None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6YZHA 1.19 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 3 - 329 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 6YPNB 1.58 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, ADP ATPlike, Allosteric 2 - 327 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CVHA 1.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP ATPlike, Allosteric 2 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5CVHB 1.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP ATPlike, Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MP8A 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, RKN ATPlike, Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MP8B 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, RKN ATPlike, Allosteric 3 - 325 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5ORJB 1.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A4Q ATPlike, Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5ORKA 2.143 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A4T ATPlike, Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7ZYKA 1.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, KEC ATPlike, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MPJA 2.14 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP, J2P ATPlike, Allosteric, Allosteric 3 - 328 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OQUA 2.324 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A4B, IHP ATPlike, Allosteric, Allosteric 4 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5OSLA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A9K, A9K ATPlike, Allosteric, Allosteric 2 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MOEB 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP, OQC, OQC ATPlike, Allosteric, Allosteric, Allosteric 4 - 326 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5ORJA 1.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, A4Q, A4Q, IHP ATPlike, Allosteric, Allosteric, Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 5MOEA 1.89 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, IHP, OQC, OQC, OQC ATPlike, Allosteric, Allosteric, Allosteric, Allosteric 3 - 327 0 None R21S Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7ZY0A 1.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KC0, ADP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 8AE7A 1.28 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LVU, ADP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7I8IA 1.47 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BZ5, ADP Type1, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7I8LA 1.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1B0I, ADP Type1, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7I8QA 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1BZU, ADP Type1, Allosteric 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC GSK3B GSK3B_HUMAN 4NM5A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 24 - 383 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 4NM7A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 25 - 383 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 4NM0A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 26 - 383 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 4NM3A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 6 - 383 0 SEP9 None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 1J1CA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 35 - 388 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 1J1CB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 23 - 386 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC MAPK1 MK01_HUMAN 4IZ5A 3.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 11 - 357 0 None T185E Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4IZ5B 3.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 11 - 357 0 None T185E Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4IZ5C 3.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 11 - 357 0 None T185E Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4IZ5D 3.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 11 - 357 0 None T185E Mitogen-activated protein kinase 1 Homo sapiens
CMGC PRP4K PRP4K_HUMAN 4IFCA 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi ADP ATPlike 668 - 1005 0 PTR849 None Serine/threonine-protein kinase PRP4 homolog Homo sapiens
CMGC PRP4K PRP4K_HUMAN 4IFCB 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi ADP ATPlike 670 - 1005 0 PTR849 None Serine/threonine-protein kinase PRP4 homolog Homo sapiens
CMGC SRPK1 SRPK1_HUMAN 1WBPA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 67 - 655 0 None None SRSF protein kinase 1 Homo sapiens
NEK NEK2 NEK2_HUMAN 2W5AA 1.55 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ADP ATPlike 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK7 NEK7_HUMAN 9NFQC 3.25 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo ADP ATPlike 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 2WQNA 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ADP ATPlike 21 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
OTHER BUB1 BUB1_HUMAN 4QPMA 2.202 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 740 - 1083 0 SEP969 None Mitotic checkpoint serine/threonine-protein kinase BUB1 Homo sapiens
OTHER BUB1 BUB1_HUMAN 4QPMB 2.202 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooo ADP ATPlike 740 - 1081 0 SEP969 None Mitotic checkpoint serine/threonine-protein kinase BUB1 Homo sapiens
OTHER BUB1 BUB1_HUMAN 4R8QA 2.31 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_iooo ADP ATPlike 736 - 1083 0 None None Mitotic checkpoint serine/threonine-protein kinase BUB1 Homo sapiens
OTHER BUB1 BUB1_HUMAN 5DMZA 2.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaoio APEdist_iooi ADP ATPlike 735 - 1083 0 SEP969 None Mitotic checkpoint serine/threonine-protein kinase BUB1 Homo sapiens
OTHER BUB1 BUB1_HUMAN 5DMZB 2.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaoio APEdist_iooi ADP ATPlike 735 - 1083 0 SEP969 None Mitotic checkpoint serine/threonine-protein kinase BUB1 Homo sapiens
OTHER CDC7 CDC7_HUMAN 4F99A 2.33 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnnn ADP ATPlike 41 - 572 0 None None Cell division cycle 7-related protein kinase Homo sapiens
OTHER CDC7 CDC7_HUMAN 4F9AA 2.17 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnnn ADP ATPlike 39 - 572 0 None None Cell division cycle 7-related protein kinase Homo sapiens
OTHER CDC7 CDC7_HUMAN 4F9AC 2.17 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnnn ADP ATPlike 37 - 572 0 None None Cell division cycle 7-related protein kinase Homo sapiens
OTHER CDC7 CDC7_HUMAN 6YA7A 1.67 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ADP ATPlike 39 - 573 0 None None Cell division cycle 7-related protein kinase Homo sapiens
OTHER CDC7 CDC7_HUMAN 6YA8A 1.79 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ADP, BEF ATPlike, Allosteric 38 - 572 0 None None Cell division cycle 7-related protein kinase Homo sapiens
OTHER EIF2AK2 E2AK2_HUMAN 6D3KA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoo APEdist_nnnn ADP ATPlike 256 - 544 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
OTHER EIF2AK2 E2AK2_HUMAN 6D3KB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanio APEdist_nnnn ADP ATPlike 255 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
OTHER EIF2AK2 E2AK2_HUMAN 6D3KC 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP ATPlike 257 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
OTHER ERN1 ERN1_HUMAN 4YZDA 3.102 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4YZDB 3.102 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_niii ADP ATPlike 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4YZDC 3.102 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_niii ADP ATPlike 563 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 3P23A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 3P23B 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoi ADP ATPlike 564 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 3P23C 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_iioi ADP ATPlike 561 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 3P23D 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_nnoi ADP ATPlike 561 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER PIK3R4 PI3R4_HUMAN 8SORA 3.96 Pseudo DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaoao APEdist_oooo ADP ATPlike 15 - 1358 0 None None Phosphoinositide 3-kinase regulatory subunit 4 Homo sapiens
OTHER RNASEL RN5A_HUMAN 4OAUC 2.6 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ADP ATPlike 25 - 719 0 None H672N 2-5A-dependent ribonuclease Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQIA 1.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3MBLA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LSG ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4ARKA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, M3K ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQGA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP, 4BM ATPlike, Type3 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6NYBB 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LCJ ATPlike, Type3 56 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 5BM, ADP Type3, ATPlike 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE PAK3 PAK3_HUMAN 6FD3A 1.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 261 - 556 0 None A537D Serine/threonine-protein kinase PAK 3 Homo sapiens
STE STK24 STK24_HUMAN 3A7JA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4O27B 3.185 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 30 - 309 0 None T190E Serine/threonine-protein kinase 24 Homo sapiens
STE STRADA STRAA_HUMAN 8VSUB 2.86 Pseudo DFGin‑None out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ADP ATPlike 60 - 401 0 None None STE20-related kinase adapter protein alpha Homo sapiens
STE TAOK3 TAOK3_HUMAN 6BDNA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 8 - 314 0 None R2A,K3A Serine/threonine-protein kinase TAO3 Homo sapiens
TKL BMPR2 BMPR2_HUMAN 3G2FA 2.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 197 - 510 0 None None Bone morphogenetic protein receptor type-2 Homo sapiens
TKL BMPR2 BMPR2_HUMAN 3G2FB 2.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 198 - 513 0 None None Bone morphogenetic protein receptor type-2 Homo sapiens
TKL BMPR2 BMPR2_HUMAN 6UNPB 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 197 - 509 0 None D485G Bone morphogenetic protein receptor type-2 Homo sapiens
TKL BMPR2 BMPR2_HUMAN 6UNPA 2.3 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_niii ADP, ADP ATPlike, Allosteric 199 - 509 0 None D485G Bone morphogenetic protein receptor type-2 Homo sapiens
TKL KSR2 KSR2_HUMAN 7JUQB 3.22 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ADP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2 Homo sapiens
TYR ABL1 ABL1_HUMAN 2G2IA 3.12 Inactive DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 229 - 502 0 None H396P Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 2G2IB 3.12 Inactive DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 232 - 500 0 None H396P Tyrosine-protein kinase ABL1 Homo sapiens
TYR ALK ALK_HUMAN 3LCTA 2.1 Inactive DFGin‑ABAminus in-none out-out TYR APEdihe_oiiai APEdist_aaao ADP ATPlike 1093 - 1400 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIWB 3.1 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIWD 3.1 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIXB 3.1 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIXD 3.1 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIYB 2.981 Inactive DFGin‑None in-in in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4RIYD 2.981 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 688 - 984 0 None V948R,F997A,L1001A Epidermal growth factor receptor Homo sapiens
TYR EPHB1 EPHB1_HUMAN 7KPMA 1.608 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 611 - 888 0 PTR647 None Ephrin type-B receptor 1 Homo sapiens
TYR ITK ITK_HUMAN 4M15A 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao QWS, ADP Type3, ATPlike 355 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR JAK1-2 JAK1_HUMAN 5KHWA 2.47 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 867 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK1-2 JAK1_HUMAN 6C7YA 2.499 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 869 - 1153 0 PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK1-2 JAK1_HUMAN 5KHWB 2.47 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 867 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
TYR KIT KIT_HUMAN 1PKGA 2.9 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 567 - 927 0 PTR568,PTR570 None Mast/stem cell growth factor receptor Kit Homo sapiens
TYR KIT KIT_HUMAN 1PKGB 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai ADP ATPlike 566 - 929 0 PTR568,PTR570 None Mast/stem cell growth factor receptor Kit Homo sapiens
TYR MERTK MERTK_HUMAN 3BRBA 1.9 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ADP ATPlike 575 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 3BRBB 1.9 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 575 - 863 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR PTK2 FAK1_HUMAN 2IJMB 2.187 Inactive DFGin‑BLBminus in-out none-out TYR APEdihe_nnoai APEdist_aaao ADP ATPlike 414 - 689 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 1MP8A 1.6 Inactive None‑None in-in none-out TYR APEdihe_nniai APEdist_aaao ADP ATPlike 414 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR TYK2-2 TYK2_HUMAN 4GVJA 2.03 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 889 - 1176 0 None C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
OTHER STT7 C1EBN1_MICCC 4IX4A 1.499 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ADP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
OTHER STT7 C1EBN1_MICCC 4IX4B 1.499 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ADP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
OTHER STT7 C1EBN1_MICCC 4IX6A 1.6 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ADP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
OTHER STT7 C1EBN1_MICCC 4IX6B 1.6 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ADP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
TKL RIPK A0A811MS43_9POAL 8HODA 1.95 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioo APEdist_oooo ADP ATPlike 82 - 379 0 None S262A,T263A non-specific serine/threonine protein kinase Miscanthus lutarioriparius
AGC PRKACA KAPCA_MOUSE 4NTTB 3.5 Inactive DFGin‑ABAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 351 0 TPO198,SEP339 K8C cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4O21A 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1L3RE 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH5A 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 5JR7A 3.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 5JR7C 3.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7UJXE 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7V0GE 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 17 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IADA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAFA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAIA 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAKA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAYA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAZA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IB0A 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IB1A 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IB3A 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4XW6A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6E21A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1JBPE 2.2 Inactive DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 10 - 351 0 SEP11,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1RDQE 1.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, ATP ATPlike, ATPlike 2 - 351 0 TPO198,SEP339 Y205A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4NTTA 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
CAMK CAMK2A KCC2A_MOUSE 7B57B 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 5 - 307 0 None T305A,T306A Calcium/calmodulin-dependent protein kinase type II subunit alpha Mus musculus
CK1 CSNK1D KC1D_MOUSE 5X17A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 3 - 292 0 None None Casein kinase I isoform delta Mus musculus
CK1 CSNK1D KC1D_MOUSE 5X17B 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 4 - 292 0 None None Casein kinase I isoform delta Mus musculus
CMGC GSK3B GSK3B_MOUSE 8VMFA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 27 - 383 0 None None Glycogen synthase kinase-3 beta Mus musculus
CMGC GSK3B GSK3B_MOUSE 8VMGA 2.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 26 - 383 0 None None Glycogen synthase kinase-3 beta Mus musculus
CMGC GSK3B GSK3B_MOUSE 8VMEA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 26 - 383 0 None None Glycogen synthase kinase-3 beta Mus musculus
CMGC GSK3B GSK3B_MOUSE 4NU1A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 6 - 383 0 SEP9 None Glycogen synthase kinase-3 beta Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL4B 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL4C 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL4D 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 961 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL5B 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL5C 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL5D 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nioi ADP ATPlike 561 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL3A 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31J, ADP Allosteric, ATPlike 560 - 964 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL3B 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31J, ADP Allosteric, ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL4A 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31K, ADP Allosteric, ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL5A 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi 31L, ADP, PEU Allosteric, ATPlike, Allosteric 562 - 964 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
TYR EPHB2 EPHB2_MOUSE 2HENA 2.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 614 - 893 0 None D746A Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 2HENB 2.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 614 - 893 0 None D746A Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 2HENC 2.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 614 - 893 0 None D746A Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 2HEND 2.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 614 - 893 0 None D746A Ephrin type-B receptor 2 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FA 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FB 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 8EWYA 5.5 Inactive None‑None in-none in-in TYR APEdihe_iiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None V657F Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 8EWYB 5.5 Inactive None‑None in-none in-in TYR APEdihe_iiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None V657F Tyrosine-protein kinase JAK1 Mus musculus
TYR SRC SRC_MOUSE 8XN8A 1.95 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ADP ATPlike 85 - 534 0 PTR529 None Proto-oncogene tyrosine-protein kinase Src Mus musculus
TYR SRC SRC_MOUSE 6F3FA 2.418 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ADP ATPlike 85 - 531 0 PTR529 None Proto-oncogene tyrosine-protein kinase Src Mus musculus
OTHER PKNB PKNB_MYCTU 3F61A 1.8 Inactive DFGin‑BLBminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn ADP ATPlike 1 - 290 0 None L33D,V222D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNG PKNG_MYCTU 4Y0XA 1.74 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oiii ADP ATPlike 83 - 404 0 None None Serine/threonine-protein kinase PknG Mycobacterium tuberculosis
OTHER PKNI PKNI_MYCTU 5M06B 2.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aanno APEdist_nnnn ADP ATPlike 2 - 255 0 None None Serine/threonine-protein kinase PknI Mycobacterium tuberculosis
STE MAP2K1 MP2K1_RABIT 7JUQC 3.22 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP ATPlike 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
OTHER FLS2 FLS2_ORYSJ 8JUVA 2.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_oooo ADP ATPlike 861 - 1178 0 None None LRR receptor-like serine/threonine-protein kinase FLS2 Oryza sativa
OTHER PINK1 PINK1_PEDHC 8UYIA 3.13 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ADP ATPlike 120 - 572 0 SEP202,TPO305 None Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
OTHER PINK1 PINK1_PEDHC 8UYIB 3.13 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ADP ATPlike 122 - 574 0 SEP202,TPO305 None Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
AGC PRKACA KAPCA_RAT 3TNQB 3.097 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 18 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Rattus norvegicus
CMGC MAPK1 MK01_RAT 4GVAA 1.83 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 356 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC FUS3 FUS3_YEAST 2B9HA 1.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 1 - 353 0 None T180V,Y182F Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC FUS3 FUS3_YEAST 2B9IA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 1 - 353 0 None T180V,Y182F Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC FUS3 FUS3_YEAST 2B9JA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 1 - 353 0 None T180V,Y182F Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC FUS3 FUS3_YEAST 2B9FA 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 1 - 353 0 None None Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC FUS3 FUS3_YEAST 2F9GA 2.1 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 1 - 353 0 PTR182 None Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC KIN28 KIN28_YEAST 6XI8A 3.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 6 - 303 0 TPO162 None Serine/threonine-protein kinase KIN28 Saccharomyces cerevisiae
CMGC KIN28 KIN28_YEAST 7KUEA 3.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 6 - 303 0 TPO162 None Serine/threonine-protein kinase KIN28 Saccharomyces cerevisiae
CMGC SKY1 SKY1_YEAST 1Q8YA 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 144 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae
OTHER BUD32 BUD32_YEAST 4WW9A 1.951 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ADP ATPlike 4 - 259 0 None None EKC/KEOPS complex subunit BUD32 Saccharomyces cerevisiae
OTHER CDC7 CDC7_YEAST 7PT78 3.8 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiio APEdist_iiii ADP, BEF ATPlike, Allosteric 10 - 475 0 None None Cell division control protein 7 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 2RIOA 2.4 None DFGin‑BLAminus out-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 665 - 1115 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 2RIOB 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 665 - 1115 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 3LJ0A 3.2 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn ADP, QUE ATPlike, Allosteric 665 - 1115 0 SEP840,SEP841,TPO844 None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 3LJ0B 3.2 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP, QUE ATPlike, Allosteric 670 - 1115 0 SEP840,SEP841,TPO844 None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSA 3.07 Inactive DFGin‑ABAminus in-out in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 943 - 1257 0 None None Guanylate cyclase Schistosoma mansoni
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSB 3.07 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai ADP ATPlike 946 - 1257 0 None None Guanylate cyclase Schistosoma mansoni
OTHER YOPO Q93KQ6_YEREN 5CE3B 2.93 Inactive None‑None none-na in-out nonTYR APEdihe_aaiii APEdist_ooii ADP ATPlike 108 - 729 0 None K205Y,E206Y,E207Y,K440Y,K441Y YopO Yersinia enterocolitica
OTHER YOPO Q93KQ6_YEREN 5CE3D 2.93 Inactive None‑None none-na in-out nonTYR APEdihe_aaiii APEdist_ooii ADP ATPlike 108 - 729 0 None K205Y,E206Y,E207Y,K440Y,K441Y YopO Yersinia enterocolitica

Ligand: ADP

Total number of chains: 111
Active chains: 46
Total number of genes: 36
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 78 70.3% 6EM7A
DFGin BLBplus 14 12.6% 8XN8A
None None 8 7.2% 4IX4A
DFGin ABAminus 5 4.5% 3TNQB
DFGin None 4 3.6% 5GZAA
DFGin BLBminus 2 1.8% 5M06B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL BRI1 BRI1_ARATH 5LPBA 1.98 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 T872A Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 5LPZA 2.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 866 - 1160 0 TPO1039,SEP1042,SEP1044 T872A Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDXA 2.23 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDXB 2.23 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDYA 2.28 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDYB 2.28 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 522 - 816 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDWA 1.926 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 521 - 815 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
TKL FERONIA FERON_ARATH 7XDWB 1.926 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 522 - 816 0 None None Receptor-like protein kinase FERONIA Arabidopsis thaliana
AGC GRK1 GRK1_BOVIN 3C4ZA 1.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C50A 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 30 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C50B 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 30 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C51A 3.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3C51B 3.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3QC9A 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None T8C,N480C Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3QC9B 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None T8C,N480C Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3QC9C 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None T8C,N480C Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 3QC9D 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 31 - 533 0 None T8C,N480C Rhodopsin kinase GRK1 Bos taurus
CK1 HRR25 Q6FS46_CANGA 4XH0A 1.99 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 3 - 397 0 None K38R non-specific serine/threonine protein kinase Candida glabrata
CK1 HRR25 Q6FS46_CANGA 4XHGA 2.15 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iioo ADP ATPlike 2 - 397 0 None K38R non-specific serine/threonine protein kinase Candida glabrata
AGC PRKACA KAPCA_CRIGR 6EM6A 1.64 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 12 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 6EM7A 1.238 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
CMGC CDK Q5CRJ8_CRYPI 3NIZA 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ADP ATPlike 1 - 293 0 None None Cyclin-dependent kinase 2 homolog Cryptosporidium parvum
CAMK PLK1 Q4KMI8_DANRE 3D5WA 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 24 - 310 0 TPO196 None Serine/threonine-protein kinase PLK Danio rerio
OTHER POMK SG196_DANRE 5GZAA 2.0 Pseudo DFGin‑None none-na in-out nonTYR APEdihe_aaioo APEdist_iioo ADP, ZZ1 ATPlike, Allosteric 53 - 342 0 None None Protein O-mannose kinase Danio rerio
CAMK CAMKII KCC2A_DROME 5FG8A 1.955 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 7 - 275 0 None None Calcium/calmodulin-dependent protein kinase type II alpha chain Drosophila melanogaster
CAMK CAMKII KCC2A_DROME 5HU3A 1.885 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 7 - 272 0 None D136N Calcium/calmodulin-dependent protein kinase type II alpha chain Drosophila melanogaster
CAMK OBSCN-1 OBSCN_DROME 8AK3A 1.9 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ADP ATPlike 3186 - 3477 0 None None Protein Obscurin Drosophila melanogaster
OTHER BUBR1 A1Z6I7_DROME 6JKMA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_iooo ADP ATPlike 1127 - 1459 0 None None Bub1-related kinase Drosophila melanogaster
CAMK CDPK Q3HNM4_EIMTE 4YSJA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 26 - 499 0 None None non-specific serine/threonine protein kinase Eimeria tenella
CAMK CDPK Q3HNM4_EIMTE 4YSJB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 26 - 499 0 None None non-specific serine/threonine protein kinase Eimeria tenella
OTHER STT7 C1EBN1_MICCC 4IX4A 1.499 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ADP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
OTHER STT7 C1EBN1_MICCC 4IX4B 1.499 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ADP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
OTHER STT7 C1EBN1_MICCC 4IX6A 1.6 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ADP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
OTHER STT7 C1EBN1_MICCC 4IX6B 1.6 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ADP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
TKL RIPK A0A811MS43_9POAL 8HODA 1.95 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioo APEdist_oooo ADP ATPlike 82 - 379 0 None S262A,T263A non-specific serine/threonine protein kinase Miscanthus lutarioriparius
AGC PRKACA KAPCA_MOUSE 4NTTB 3.5 Inactive DFGin‑ABAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 351 0 TPO198,SEP339 K8C cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4O21A 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1L3RE 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 2 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH5A 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 5JR7A 3.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 5JR7C 3.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7UJXE 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7V0GE 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 17 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IADA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAFA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAIA 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAKA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAYA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IAZA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IB0A 1.87 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IB1A 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4IB3A 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4XW6A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6E21A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1JBPE 2.2 Inactive DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 10 - 351 0 SEP11,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 1RDQE 1.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP, ATP ATPlike, ATPlike 2 - 351 0 TPO198,SEP339 Y205A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4NTTA 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
CAMK CAMK2A KCC2A_MOUSE 7B57B 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 5 - 307 0 None T305A,T306A Calcium/calmodulin-dependent protein kinase type II subunit alpha Mus musculus
CK1 CSNK1D KC1D_MOUSE 5X17A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 3 - 292 0 None None Casein kinase I isoform delta Mus musculus
CK1 CSNK1D KC1D_MOUSE 5X17B 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP Type1.5_Back 4 - 292 0 None None Casein kinase I isoform delta Mus musculus
CMGC GSK3B GSK3B_MOUSE 8VMFA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 27 - 383 0 None None Glycogen synthase kinase-3 beta Mus musculus
CMGC GSK3B GSK3B_MOUSE 8VMGA 2.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 26 - 383 0 None None Glycogen synthase kinase-3 beta Mus musculus
CMGC GSK3B GSK3B_MOUSE 8VMEA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 26 - 383 0 None None Glycogen synthase kinase-3 beta Mus musculus
CMGC GSK3B GSK3B_MOUSE 4NU1A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 6 - 383 0 SEP9 None Glycogen synthase kinase-3 beta Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL4B 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL4C 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL4D 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 961 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL5B 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL5C 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi ADP ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL5D 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nioi ADP ATPlike 561 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL3A 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31J, ADP Allosteric, ATPlike 560 - 964 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL3B 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31J, ADP Allosteric, ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL4A 3.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 31K, ADP Allosteric, ATPlike 562 - 963 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
OTHER ERN1 ERN1_MOUSE 4PL5A 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioi 31L, ADP, PEU Allosteric, ATPlike, Allosteric 562 - 964 0 None N772Y Serine/threonine-protein kinase/endoribonuclease IRE1 Mus musculus
TYR EPHB2 EPHB2_MOUSE 2HENA 2.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 614 - 893 0 None D746A Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 2HENB 2.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 614 - 893 0 None D746A Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 2HENC 2.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 614 - 893 0 None D746A Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 2HEND 2.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan ADP ATPlike 614 - 893 0 None D746A Ephrin type-B receptor 2 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FA 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FB 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 8EWYA 5.5 Inactive None‑None in-none in-in TYR APEdihe_iiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None V657F Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 8EWYB 5.5 Inactive None‑None in-none in-in TYR APEdihe_iiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None V657F Tyrosine-protein kinase JAK1 Mus musculus
TYR SRC SRC_MOUSE 8XN8A 1.95 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ADP ATPlike 85 - 534 0 PTR529 None Proto-oncogene tyrosine-protein kinase Src Mus musculus
TYR SRC SRC_MOUSE 6F3FA 2.418 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ADP ATPlike 85 - 531 0 PTR529 None Proto-oncogene tyrosine-protein kinase Src Mus musculus
OTHER PKNB PKNB_MYCTU 3F61A 1.8 Inactive DFGin‑BLBminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn ADP ATPlike 1 - 290 0 None L33D,V222D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNG PKNG_MYCTU 4Y0XA 1.74 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oiii ADP ATPlike 83 - 404 0 None None Serine/threonine-protein kinase PknG Mycobacterium tuberculosis
OTHER PKNI PKNI_MYCTU 5M06B 2.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aanno APEdist_nnnn ADP ATPlike 2 - 255 0 None None Serine/threonine-protein kinase PknI Mycobacterium tuberculosis
STE MAP2K1 MP2K1_RABIT 7JUQC 3.22 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP ATPlike 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
OTHER FLS2 FLS2_ORYSJ 8JUVA 2.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_oooo ADP ATPlike 861 - 1178 0 None None LRR receptor-like serine/threonine-protein kinase FLS2 Oryza sativa
OTHER PINK1 PINK1_PEDHC 8UYIA 3.13 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ADP ATPlike 120 - 572 0 SEP202,TPO305 None Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
OTHER PINK1 PINK1_PEDHC 8UYIB 3.13 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ADP ATPlike 122 - 574 0 SEP202,TPO305 None Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
AGC PRKACA KAPCA_RAT 3TNQB 3.097 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 18 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Rattus norvegicus
CMGC MAPK1 MK01_RAT 4GVAA 1.83 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 11 - 356 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC FUS3 FUS3_YEAST 2B9HA 1.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 1 - 353 0 None T180V,Y182F Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC FUS3 FUS3_YEAST 2B9IA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 1 - 353 0 None T180V,Y182F Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC FUS3 FUS3_YEAST 2B9JA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 1 - 353 0 None T180V,Y182F Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC FUS3 FUS3_YEAST 2B9FA 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ADP ATPlike 1 - 353 0 None None Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC FUS3 FUS3_YEAST 2F9GA 2.1 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 1 - 353 0 PTR182 None Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae
CMGC KIN28 KIN28_YEAST 6XI8A 3.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 6 - 303 0 TPO162 None Serine/threonine-protein kinase KIN28 Saccharomyces cerevisiae
CMGC KIN28 KIN28_YEAST 7KUEA 3.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 6 - 303 0 TPO162 None Serine/threonine-protein kinase KIN28 Saccharomyces cerevisiae
CMGC SKY1 SKY1_YEAST 1Q8YA 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 144 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae
OTHER BUD32 BUD32_YEAST 4WW9A 1.951 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ADP ATPlike 4 - 259 0 None None EKC/KEOPS complex subunit BUD32 Saccharomyces cerevisiae
OTHER CDC7 CDC7_YEAST 7PT78 3.8 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiio APEdist_iiii ADP, BEF ATPlike, Allosteric 10 - 475 0 None None Cell division control protein 7 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 2RIOA 2.4 None DFGin‑BLAminus out-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP ATPlike 665 - 1115 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 2RIOB 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 665 - 1115 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 3LJ0A 3.2 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn ADP, QUE ATPlike, Allosteric 665 - 1115 0 SEP840,SEP841,TPO844 None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 3LJ0B 3.2 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn ADP, QUE ATPlike, Allosteric 670 - 1115 0 SEP840,SEP841,TPO844 None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSA 3.07 Inactive DFGin‑ABAminus in-out in-none TYR APEdihe_nniai APEdist_aaai ADP ATPlike 943 - 1257 0 None None Guanylate cyclase Schistosoma mansoni
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSB 3.07 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai ADP ATPlike 946 - 1257 0 None None Guanylate cyclase Schistosoma mansoni
OTHER YOPO Q93KQ6_YEREN 5CE3B 2.93 Inactive None‑None none-na in-out nonTYR APEdihe_aaiii APEdist_ooii ADP ATPlike 108 - 729 0 None K205Y,E206Y,E207Y,K440Y,K441Y YopO Yersinia enterocolitica
OTHER YOPO Q93KQ6_YEREN 5CE3D 2.93 Inactive None‑None none-na in-out nonTYR APEdihe_aaiii APEdist_ooii ADP ATPlike 108 - 729 0 None K205Y,E206Y,E207Y,K440Y,K441Y YopO Yersinia enterocolitica