STE / All / All

Total number of chains: 786
Active chains: 193
Total number of genes: 46
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 409 52.0% AF-Q02750-K1A
DFGin BLBplus 134 17.0% 9AXXA
DFGout None 61 7.8% 9N7RA
DFGin None 47 6.0% 9H8FA
DFGin BLBminus 33 4.2% 4LGDA
DFGout BBAminus 33 4.2% 6EIMB
None None 24 3.1% 7F2XA
DFGinter None 14 1.8% 4U3YA
DFGin ABAminus 13 1.7% 6NFYB
DFGin BLAplus 9 1.1% 9N4UB
DFGin BLBtrans 7 0.9% 3DAKD
DFGinter BABtrans 2 0.3% 2CLQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP2K1 MP2K1_HUMAN AF-Q02750-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 369 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN AF-Q02750-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 369 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8CHFE 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8CHFF 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQDA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQIA 1.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3C 2.9 Inactive DFGin‑BLBplus out-none none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6U2GA 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6V2WB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEA 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 63 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNED 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 66 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8DGSB 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type1 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN3A 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onno ATP, 5Y0 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN9A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onoo ACP, 2P7 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RA 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, T1K ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RB 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T1K ATPlike, Type3 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94A 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, T3W ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94B 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T3W ATPlike, Type3 41 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LA 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LB 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ORNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3OR ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3OS3A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 3OS ATPlike, Type3 62 - 378 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3WIGA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DV3A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ATP, MEK ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3MBLA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LSG ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3PP1A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, IZG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQBA 2.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, LUG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U80A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ANP, 3EX ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 1S9JA 2.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, BBM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DY7A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ATP, 1CX ATPlike, Type3 62 - 364 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3E8NA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo ATP, VRA ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHB 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHC 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ARKA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, M3K ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4LMNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEE 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQGA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP, 4BM ATPlike, Type3 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7UMBC 3.231 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, U9F ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6PP9B 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, LCJ ATPlike, Type3 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0VB 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0WB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOA ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0XB 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0YB 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 43 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0ZB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8DGTB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type3 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6NYBB 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LCJ ATPlike, Type3 56 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9MMPB 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9MMQB 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9MMRB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9MMSB 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 63 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEH 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ACP, 573, 573 ATPlike, Type3, Allosteric 66 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXMC 2.42 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type1 43 - 376 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7PQVA 2.13 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 80C Type1 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ZLSA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 92P Type1 39 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ZLXA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5EZ Type1 39 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ZM4A 2.37 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 22T Type1 40 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5BX0A 2.93 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 4W5 Type1 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7XNCA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo GIK Type1 37 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ZLYA 2.11 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo YSO Type1 40 - 382 0 None S298N,S299N,Y300K Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5EYMA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 41 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5EYMB 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 41 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQFA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo KSA Type1 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UB 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type1 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ZLWA 2.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo MT8 Type1 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHA 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 39 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHB 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXMA 2.42 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXA 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 41 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXC 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 37 - 378 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAB 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 42 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAD 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno A1AHE, ANP Type1, ATPlike 39 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AY7B 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 33 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UH 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VB 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VH 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7XLPA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno FZC Type1.5_Back 37 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7MFDB 3.66 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU Type3 52 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O2ZB 3.83 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU Type3 52 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXAB 4.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 52 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXAD 4.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 59 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXCB 4.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 52 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXCD 4.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1AHE Type3 59 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UD 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type3 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UF 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type3 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN2A 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo EUI, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ANBA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YQY, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 2P55A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo MRA, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U7ZA 2.805 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo 3EW, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U81A 2.701 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3EY, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V01A 2.705 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3V0, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V04A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo V04, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQCA 1.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 3BM, AGS Type3, ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 5BM, ADP Type3, ATPlike 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9ECUB 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1BIS, ANP Type3, ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXYB 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type3, ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VD 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VF 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0TB 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo 3EW, ANP Type3, ATPlike 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0UB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo QO7, ANP Type3, ATPlike 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3B 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8YP4A 2.35 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo WNT Type1 34 - 384 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3A 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5HZEA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo E62 Type1 43 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8YP4B 2.35 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn WNT Type1 43 - 383 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7F2XA 2.007 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 45 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3W8QA 2.2 Inactive None‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo AGS ATPlike 39 - 382 0 None T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6Q0TC 5.7 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6Q0JC 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6Q0JD 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K2 MP2K2_HUMAN AF-P36507-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 64 - 377 0 None None Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K2 MP2K2_HUMAN AF-P36507-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 64 - 377 0 None None Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K2 MP2K2_HUMAN 1S9IA 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ATP, 5EA ATPlike, Type3 60 - 393 0 None None Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K2 MP2K2_HUMAN 1S9IB 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ATP, 5EA ATPlike, Type3 59 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K3 MP2K3_HUMAN AF-P46734-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 56 - 333 0 None None Dual specificity mitogen-activated protein kinase kinase 3
STE MAP2K3 MP2K3_HUMAN AF-P46734-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 56 - 333 0 None None Dual specificity mitogen-activated protein kinase kinase 3
STE MAP2K4 MP2K4_HUMAN AF-P45985-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 94 - 375 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN AF-P45985-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 94 - 375 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNA 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 83 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNB 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 84 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALOA 2.6 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoao APEdist_oooo ANP ATPlike 95 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 8YP5A 2.5 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoai APEdist_oooo 1FM Type1 80 - 392 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNC 2.3 Inactive None‑None none-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 100 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3VUTA 3.5 Inactive None‑None none-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 142 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3VUTB 3.5 Inactive None‑None out-na out-out nonTYR APEdihe_aannn APEdist_iooo No_ligand No_ligand 80 - 373 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K5 MP2K5_HUMAN AF-Q13163-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 158 - 427 0 None None Dual specificity mitogen-activated protein kinase kinase 5
STE MAP2K5 MP2K5_HUMAN AF-Q13163-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 158 - 427 0 None None Dual specificity mitogen-activated protein kinase kinase 5
STE MAP2K6 MP2K6_HUMAN AF-P52564-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 45 - 322 0 None None Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN AF-P52564-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 45 - 322 0 None None Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8A8MB 4.0 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn AP2 Type1 38 - 334 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMA 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 46 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMB 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 49 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMC 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 48 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMD 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 45 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8P7JA 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8P7JB 2.4 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8PM3A 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8PM3B 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8PM3C 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8PM3D 2.0 Inactive DFGout‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3FMEA 2.26 Inactive None‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno STU Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3VN9A 2.6 Inactive None‑None out-na out-out nonTYR APEdihe_aaiao APEdist_oooo ANK Type1 44 - 334 0 None None Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K7 MP2K7_HUMAN 6QFLA 2.2 Inactive DFGin‑ABAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6QFTA 2.7 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aanai APEdist_nnnn J0B Type1 102 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6QG4A 2.3 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn J0E Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6QG7A 2.1 Inactive DFGin‑ABAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 6HL Type1 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6QHOA 2.7 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn J3H Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN AF-O14733-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 112 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN AF-O14733-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 112 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 2DYLA 2.45 None DFGin‑BLAminus in-na none-none nonTYR APEdihe_aanai APEdist_nnnn No_ligand No_ligand 103 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG1A 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 86 - 404 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG1B 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 93 - 404 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG1C 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 86 - 405 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5Z1DA 2.28 None DFGin‑BLAminus in-na none-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG3A 2.05 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn 6HF Type1 103 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6IB0A 2.6 Inactive DFGin‑BLAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi H8Z Type1 101 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6QHRA 2.52 Inactive DFGin‑BLAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi J3N Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVIA 1.95 Inactive DFGin‑BLAplus in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2GI Type1.5_Front 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVJA 2.35 Inactive DFGin‑BLBplus in-na none-none nonTYR APEdihe_aaiai APEdist_nnni 24N Type1.5_Front 102 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5B2MA 3.06 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 105 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVLA 2.9 Inactive DFGin‑None in-na none-out nonTYR APEdihe_aaiai APEdist_nnoi 1XZ Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVMA 2.9 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni 21I Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVNA 2.9 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 2I8 Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 9HZ0A 2.25 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni A1IY7 Type1 101 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVKA 2.05 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2I5 Type1.5_Back 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6IB2A 2.1 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 862 Type1.5_Front 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG7A 2.2 Inactive DFGout‑BBAminus out-na none-out nonTYR APEdihe_aanao APEdist_nnnn OQ2 Type2 102 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG7B 2.2 Inactive DFGout‑BBAminus out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ2 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YZ4A 1.7 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno 1E8 Allosteric 101 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5Y8UA 2.92 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnoo No_ligand No_ligand 103 - 402 0 None C260S Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5Y90A 1.3 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 103 - 419 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5B2LA 2.1 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni No_ligand No_ligand 104 - 403 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YFZA 1.9 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 100 - 405 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6QFRA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5B2KA 2.75 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 104 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG0A 2.0 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7CBXA 2.061 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn FU6 Type1 103 - 402 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5Z1EA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 419 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG4A 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn SU9 Type1 103 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG5A 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn IHH Type1 101 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 3WZUA 3.01 Inactive DFGout‑None none-na none-out nonTYR APEdihe_aaoai APEdist_nnno 1FM Type1 104 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG6A 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG6B 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 104 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG2A 2.0 Inactive None‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn 1E8, 8E8 Allosteric, Type1.5_Front 102 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP3K1 M3K1_HUMAN AF-Q13233-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1235 - 1512 0 None None Mitogen-activated protein kinase kinase kinase 1
STE MAP3K1 M3K1_HUMAN AF-Q13233-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1235 - 1512 0 None None Mitogen-activated protein kinase kinase kinase 1
STE MAP3K14 M3K14_HUMAN 4IDTA 2.4 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi T28 Type1 333 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4DN5A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_noii AGS ATPlike 332 - 675 0 None S549D Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4DN5B 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_noii AGS ATPlike 333 - 675 0 None S549D Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 8YHWA 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 8YHWB 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 8YHWC 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 8YHWD 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS, PE8 ATPlike, Allosteric 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN AF-Q99558-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 391 - 661 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN AF-Q99558-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 391 - 661 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4G3DA 2.9 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_ioii No_ligand No_ligand 332 - 672 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4G3DB 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 332 - 666 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4G3DD 2.9 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii No_ligand No_ligand 338 - 657 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4G3DE 2.9 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanin APEdist_nnii No_ligand No_ligand 332 - 663 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 6WPPA 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi PZ4 Type1 344 - 674 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 6WPPB 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi PZ4 Type1 343 - 674 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 6Z1QAAA 2.42 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi Q58 Type1 332 - 676 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 6Z1QBBB 2.42 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi Q58 Type1 332 - 677 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 6Z1TAAA 2.31 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi Q55 Type1 334 - 676 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 6Z1TBBB 2.31 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi Q55 Type1 332 - 677 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4IDTB 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi T28 Type1 334 - 677 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4IDVA 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 13V Type1.5_Back 331 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4IDVB 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 13V Type1.5_Back 331 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4IDVC 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 13V Type1.5_Back 331 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4IDVD 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 13V Type1.5_Back 331 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K15 M3K15_HUMAN AF-Q6ZN16-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 637 - 916 0 None None Mitogen-activated protein kinase kinase kinase 15
STE MAP3K15 M3K15_HUMAN AF-Q6ZN16-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 637 - 916 0 None None Mitogen-activated protein kinase kinase kinase 15
STE MAP3K19 M3K19_HUMAN AF-Q56UN5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1053 - 1328 0 None None Mitogen-activated protein kinase kinase kinase 19
STE MAP3K19 M3K19_HUMAN AF-Q56UN5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1053 - 1328 0 None None Mitogen-activated protein kinase kinase kinase 19
STE MAP3K2 M3K2_HUMAN AF-Q9Y2U5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 348 - 619 0 None None Mitogen-activated protein kinase kinase kinase 2
STE MAP3K2 M3K2_HUMAN AF-Q9Y2U5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 348 - 619 0 None None Mitogen-activated protein kinase kinase kinase 2
STE MAP3K2 M3K2_HUMAN 9P6AA 2.4 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_oooo 0LI Type2 351 - 617 0 None None Mitogen-activated protein kinase kinase kinase 2
STE MAP3K2 M3K2_HUMAN 9P6AB 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnoo 0LI Type2 347 - 618 0 None None Mitogen-activated protein kinase kinase kinase 2
STE MAP3K3 M3K3_HUMAN AF-Q99759-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 354 - 626 0 None None Mitogen-activated protein kinase kinase kinase 3
STE MAP3K3 M3K3_HUMAN AF-Q99759-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 354 - 626 0 None None Mitogen-activated protein kinase kinase kinase 3
STE MAP3K4 M3K4_HUMAN AF-Q9Y6R4-K1A -1.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii No_ligand No_ligand 1335 - 1608 0 None None Mitogen-activated protein kinase kinase kinase 4
STE MAP3K4 M3K4_HUMAN AF-Q9Y6R4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1335 - 1608 0 None None Mitogen-activated protein kinase kinase kinase 4
STE MAP3K5 M3K5_HUMAN AF-Q99683-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 665 - 946 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN AF-Q99683-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 665 - 946 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BICB 2.62 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnoi No_ligand No_ligand 670 - 941 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 8QGYB 3.71 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYTA 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn NJV Type1 667 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYTB 2.824 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnno NJV Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYTC 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn NJV Type1 671 - 938 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYTD 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni NJV Type1 667 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5UOXA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GY Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5UOXB 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GY Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5UP3A 2.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GS Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5UP3B 2.95 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 8GS Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5V19A 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V4 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5V19B 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5V24A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 8V7 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5V24B 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V7 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 3VW6A 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi IM6 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 3VW6B 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi IM6 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5UORA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 8GV Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5UORB 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GV Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VILA 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VILB 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VILD 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VIOA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VIOB 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VIOD 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6XIHA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi V3S Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6XIHB 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnni V3S Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6E2MA 2.253 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KK7 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6E2MB 2.253 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi KK7 Type1 671 - 940 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6E2NA 2.098 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KK8 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6E2NB 2.098 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii KK8 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6E2OA 2.389 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii S0L Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6E2OB 2.389 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi S0L Type1 671 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6VREA 2.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi RFG Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6VREB 2.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi RFG Type1 669 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYWA 2.603 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYWB 2.603 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi NKJ Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYWC 2.603 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYWD 2.603 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BIBA 2.43 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi IEO Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BIBB 2.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi IEO Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BICA 2.62 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE4 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BIDA 2.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE8 Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BIDB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE8 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BIEA 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi IE6 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BIEB 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE6 Type1 670 - 941 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BF2A 2.11 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BF2B 2.11 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_nnoi STU Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BHNA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BH9 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BHNB 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi BH9 Type1 670 - 938 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 7MU6A 2.165 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi A1AWT Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 7MU6B 2.165 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii A1AWT Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 7MU7A 2.298 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi RFG Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 7MU7B 2.298 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi RFG Type1 669 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VIOC 2.84 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VILC 2.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQA 2.3 Inactive DFGinter‑BABtrans out-out in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB 2.3 Inactive DFGinter‑BABtrans in-none in-out nonTYR APEdihe_aaiii APEdist_nooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 8QGYA 3.71 Inactive DFGout‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K6 M3K6_HUMAN AF-O95382-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 635 - 914 0 None None Mitogen-activated protein kinase kinase kinase 6
STE MAP3K6 M3K6_HUMAN AF-O95382-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 635 - 914 0 None None Mitogen-activated protein kinase kinase kinase 6
STE MAP3K8 M3K8_HUMAN AF-P41279-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 119 - 396 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN AF-P41279-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 119 - 396 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN 4Y83A 2.89 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 49B Type1 73 - 389 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN 4Y83B 2.89 Inactive DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 49B Type1 73 - 390 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN 4Y83C 2.89 Inactive DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 49B Type1 74 - 389 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN 4Y85A 2.33 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 499 Type1 73 - 390 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN 4Y85B 2.33 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 499 Type1 73 - 390 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN 4Y85C 2.33 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 499 Type1 73 - 390 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN 5IU2A 2.7 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 6DA Type1 73 - 389 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP3K8 M3K8_HUMAN 5IU2B 2.7 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 6DA Type1 73 - 389 0 None None Mitogen-activated protein kinase kinase kinase 8
STE MAP4K1 M4K1_HUMAN 6NFYA 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi B49 Type1 10 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFYB 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioi B49 Type1 10 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQDA 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 2 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQDB 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN AF-Q92918-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 282 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN AF-Q92918-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 282 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7KACB 1.85 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo W9D Type1 7 - 294 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0MA 1.93 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo YK1 Type1 2 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0MB 1.93 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo YK1 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9NA 1.5 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9NB 1.5 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9PA 2.27 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2WI Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9PB 2.27 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2WI Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9TA 2.0 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2TR Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9TB 2.0 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2TR Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZTA 1.69 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1E Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZTB 1.69 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1E Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZUA 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZUB 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nooo A1A1D Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZUC 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 2 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZUD 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 8 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZWA 1.59 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo A1A1C Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZWB 1.59 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1C Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZXA 1.464 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1B Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9D00A 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9D00B 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9D00C 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9D00D 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BIKB 2.25 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APO Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BJ1A 2.18 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APR Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9NACA 1.45 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWM Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9NACB 1.45 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1BWM Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9NBSA 1.8 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BW4 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9NBSB 1.8 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BW4 Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9NC2A 1.5 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 3 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9NC2B 1.5 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFZA 2.966 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 7 - 292 0 TPO165,SEP171 None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFZB 2.966 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 5 - 292 0 TPO165,SEP171 None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4A 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4B 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4C 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4D 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno XXF Type1 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FJZA 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 3 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FJZB 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FJZC 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FJZD 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FJZE 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo Y3I Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FJZF 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 9 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FKOA 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3O Type1 4 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FKOB 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FKOC 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FKOD 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FKOE 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo Y3O Type1 9 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L24A 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aannn APEdist_onnn XHV Type1 7 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L24B 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo XHV Type1 7 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L24C 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanii APEdist_ooon XHV Type1 8 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L24D 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XHV Type1 8 - 292 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9CZXB 1.464 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1B, A1A1B Type1, Allosteric 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BJ1B 2.18 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1APQ Type1.5_Back 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7KACA 1.85 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno W9D Type1 7 - 304 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8DA 1.641 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITC Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8EA 1.631 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITA Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8FA 1.393 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITB Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A 1.76 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo A1JAF Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo B49 Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQFA 2.246 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo F97 Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9LA 2.332 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo 2YE Type1 7 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26A 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26B 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26C 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26D 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L25A 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 7 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L25B 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 6 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7SIUA 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oioo 9ID Type1.5_Back 5 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7SIUB 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9ID Type1.5_Back 16 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BI8A 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BI8B 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N9XA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N9XB 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0KA 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0KB 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 8 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0KC 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 8 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0KD 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0LA 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0LB 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 7 - 291 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0LC 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7M0LD 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8XN7A 2.65 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo A1LVT Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8XN7B 2.65 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo A1LVT Type1 6 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0B 2.05 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo B49 Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BIKA 2.25 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_oooo A1APO Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N7RB 2.13 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWC Type1 8 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N7RA 2.13 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo A1BWC, A1BWC, A1BWC, A1BWC Allosteric, Allosteric, Type1, Type3 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PAUA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PAUB 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PASA 2.7 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 8 - 295 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PASB 2.7 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CDWA 1.941 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CIJA 2.821 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni USF Type1 14 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PARA 2.0 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XON Type1 7 - 294 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FKOF 2.104 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 57 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQEA 1.886 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 4 - 293 0 None S171A Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQEB 1.886 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 5 - 293 0 None S171A Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CDWB 1.941 Inactive None‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 9 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K2 M4K2_HUMAN AF-Q12851-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 8 - 281 0 None None Mitogen-activated protein kinase kinase kinase kinase 2
STE MAP4K2 M4K2_HUMAN AF-Q12851-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 8 - 281 0 None None Mitogen-activated protein kinase kinase kinase kinase 2
STE MAP4K3 M4K3_HUMAN AF-Q8IVH8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 8 - 281 0 None None Mitogen-activated protein kinase kinase kinase kinase 3
STE MAP4K3 M4K3_HUMAN AF-Q8IVH8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 8 - 281 0 None None Mitogen-activated protein kinase kinase kinase kinase 3
STE MAP4K3 M4K3_HUMAN 5J5TA 2.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo 6G2 Type1 13 - 314 0 TPO145 S170A Mitogen-activated protein kinase kinase kinase kinase 3
STE MAP4K4 M4K4_HUMAN AF-O95819-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN AF-O95819-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 8V5IA 2.18 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo A1AAA Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBPA 2.27 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 2QU Type1 13 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U44A 2.43 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iioo 3D9 Type1 12 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U45A 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 3DC Type1 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4ZK5A 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 4P4 Type1 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U40A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U42A 2.504 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 3C8 Type1 16 - 310 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4ZP5A 2.29 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 4QG Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5DI1A 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 5DF Type1 13 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5J95A 2.5 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 6HH Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4RVTA 2.4 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_oooo 3XM Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBOA 2.1 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 2QV Type1 16 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBQA 2.19 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_iioo 2QT Type1 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U41A 2.2 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 3C8 Type1 16 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U43A 2.18 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo 3D8 Type1 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5W5QA 2.33 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9X4 Type1.5_Back 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U3ZA 2.09 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U3YA 1.45 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U3YB 1.45 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 8 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U3ZB 2.09 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4ZP5B 2.29 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5DI1B 2.9 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5J95B 2.5 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 8V5IB 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4RVTB 2.4 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBOB 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBPB 2.27 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBQB 2.19 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U40B 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U41B 2.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U43B 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U44B 2.43 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U45B 2.58 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4ZK5B 2.89 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5W5QB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U42B 2.504 Inactive None‑None none-none none-out nonTYR APEdihe_aaioi APEdist_oooo 3C8 Type1 17 - 310 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K5 M4K5_HUMAN AF-Q9Y4K4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 285 0 None None Mitogen-activated protein kinase kinase kinase kinase 5
STE MAP4K5 M4K5_HUMAN AF-Q9Y4K4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 285 0 None None Mitogen-activated protein kinase kinase kinase kinase 5
STE MINK1 MINK1_HUMAN AF-Q8N4C8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Misshapen-like kinase 1
STE MINK1 MINK1_HUMAN AF-Q8N4C8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Misshapen-like kinase 1
STE MYO3A MYO3A_HUMAN AF-Q8NEV4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 295 0 None None Myosin-IIIa
STE MYO3A MYO3A_HUMAN AF-Q8NEV4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 295 0 None None Myosin-IIIa
STE MYO3B MYO3B_HUMAN AF-Q8WXR4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 301 0 None None Myosin-IIIb
STE MYO3B MYO3B_HUMAN AF-Q8WXR4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 301 0 None None Myosin-IIIb
STE NRK NRK_HUMAN AF-Q7Z2Y5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 321 0 None None Nik-related protein kinase
STE NRK NRK_HUMAN AF-Q7Z2Y5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 321 0 None None Nik-related protein kinase
STE OXSR1 OXSR1_HUMAN AF-O95747-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 299 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN AF-O95747-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 299 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKA 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ANP ATPlike 6 - 295 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKB 2.25 Inactive DFGin‑BLBtrans out-out out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 6 - 295 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKC 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 7 - 295 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKD 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nooo ANP ATPlike 7 - 295 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIB 2.15 Inactive DFGin‑BLBtrans out-out out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 9 - 292 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIC 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo ANP ATPlike 9 - 292 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWID 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 6 - 298 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIA 2.15 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 13 - 292 0 None None Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 9N48B 1.85 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1BV1 Type1 255 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3Q53A 2.09 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 250 - 541 0 TPO423 K299R,L516I Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3Q4ZA 1.887 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 251 - 545 0 None S259I,K299R,D389N,L516I Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN AF-Q13153-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 262 - 529 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN AF-Q13153-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 262 - 529 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZLOB 2.5 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 253 - 543 0 TPO423 None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3Q52A 1.801 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 250 - 542 0 TPO423 K299R,L516I Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 1YHWA 1.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 541 0 None K299R Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 8X5ZA 1.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 543 0 TPO423 K299R,E503D Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 1YHVA 1.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 541 0 None K299R,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4O0RB 2.4 Inactive DFGin‑BLAminus out-out none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 249 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3FXZA 1.64 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii FLL Type1 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3FY0A 2.35 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii DW1 Type1 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4DAWA 2.0 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii 0H2 Type1 249 - 542 0 TPO423 K299R Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZY4A 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4T3 Type1 249 - 541 0 None D389N Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZY5A 2.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4T5 Type1 251 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZY6A 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4T6 Type1 251 - 542 0 None D389N Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 6B16A 2.285 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii C7Y Type1 251 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 7VTOA 2.59 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 107 Type1 257 - 542 0 TPO423 None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 2HY81 2.0 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii 1ST Type1 249 - 541 0 None K299R,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D4XA 1.847 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2S Type1 252 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D50A 1.898 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2T Type1 250 - 544 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5DEWA 1.9 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 59N Type1 250 - 544 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D4VA 1.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2P Type1 252 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D4WA 2.218 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2Q Type1 252 - 544 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D4YA 1.847 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2S Type1 252 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4O0RA 2.4 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 7KC Type1 249 - 541 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5KBQA 2.58 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii IPV Type1 254 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5KBRA 2.36 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii IPW Type1 255 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4P90A 2.49 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 2K0 Type1 250 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9N48A 1.85 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BV1 Type1 249 - 545 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9NBXA 2.15 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW5 Type1 249 - 541 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4EQCA 2.01 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii XR1 Type1.5_Back 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5DEYA 2.1 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 59T Type1.5_Back 250 - 544 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4O0TA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2OL Type1.5_Back 251 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5IMEA 2.217 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6BZ Type1.5_Back 251 - 545 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9N4UA 1.77 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BV8 Type1.5_Back 249 - 545 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5DFPA 2.2 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii 59U Type1.5_Front 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 1F3MC 2.3 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaioo APEdist_oooo No_ligand No_ligand 249 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 1F3MD 2.3 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 249 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZY6B 2.15 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo 4T6 Type1 255 - 542 0 None D389N Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9N4UB 1.77 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaiio APEdist_nnno A1BV8 Type1 255 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D4XB 1.847 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaiio APEdist_nnno A1A2S Type1 256 - 543 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D4YB 1.847 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaiio APEdist_nnno A1A2S Type1 256 - 543 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZY4B 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_oooo 4T3 Type1 249 - 541 0 None D389N Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZY5B 2.35 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_oooo 4T5 Type1 255 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 6B16B 2.285 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiio APEdist_nnno C7Y Type1 255 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5DEWB 1.9 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo 59N Type1 255 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D4VB 1.84 Inactive DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaiio APEdist_nnno A1A2P Type1 252 - 543 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D4WB 2.218 Inactive DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaiio APEdist_nnno A1A2Q Type1 257 - 545 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9NBXB 2.15 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1BW5 Type1 254 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4O0TB 2.6 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 255 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3Q4ZB 1.887 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 250 - 541 0 None S259I,K299R,D389N,L516I Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 7VTOB 2.59 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 107 Type1 255 - 542 0 TPO423 None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5DEYB 2.1 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_oooo 59T Type1 255 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5IMEB 2.217 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 6BZ Type1 250 - 541 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 9D50B 1.898 Inactive DFGinter‑None in-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1A2T Type1 253 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJIA 1.99 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi 4OQ Type3 254 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJIB 1.99 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi 4OQ Type3 254 - 540 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJIC 1.99 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 4OQ Type3 250 - 541 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJID 1.99 Inactive DFGout‑BBAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo 4OQ Type3 253 - 541 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJA 2.2 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi 4OR Type3 249 - 539 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJB 2.2 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi 4OR Type3 251 - 539 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJC 2.2 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaiii APEdist_nnno 4OR Type3 251 - 542 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJD 2.2 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaiii APEdist_oooo 4OR Type3 252 - 541 0 None None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZLOA 2.5 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno 4PV Type3 250 - 543 0 TPO423 None Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5KBQB 2.58 Inactive None‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno No_ligand No_ligand 255 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5KBRB 2.36 Inactive None‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno IPW Type1 255 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4P90B 2.49 Inactive None‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno 2K0 Type1 257 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1
STE PAK2 PAK2_HUMAN AF-Q13177-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 241 - 507 0 None None Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN AF-Q13177-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 241 - 507 0 None None Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN 9D51A 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2Q Type1 230 - 523 0 None D368N,T402E,P498Q,M514A Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN 9LBGB 2.89 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aanoo APEdist_nnnn MLT Allosteric 91 - 522 0 None K278R Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN 9LBGA 2.89 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaioo APEdist_nnoo No_ligand No_ligand 84 - 522 0 None K278R Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN 9LBFA 2.62 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiio APEdist_nnoo No_ligand No_ligand 86 - 522 0 None D368N Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN 9LBFB 2.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 93 - 522 0 None D368N Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN 9D51B 2.1 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1A2Q Type1 231 - 522 0 None D368N,T402E,P498Q,M514A Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN 9M41A 3.02 Inactive DFGout‑BBAminus out-none out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 85 - 520 0 None K278R,D368N Serine/threonine-protein kinase PAK 2
STE PAK2 PAK2_HUMAN 9M41B 3.02 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 83 - 521 0 None K278R,D368N Serine/threonine-protein kinase PAK 2
STE PAK3 PAK3_HUMAN 6FD3A 1.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 261 - 556 0 None A537D Serine/threonine-protein kinase PAK 3
STE PAK3 PAK3_HUMAN AF-O75914-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 275 - 542 0 None None Serine/threonine-protein kinase PAK 3
STE PAK3 PAK3_HUMAN AF-O75914-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 275 - 542 0 None None Serine/threonine-protein kinase PAK 3
STE PAK4 PAK4_HUMAN 4XBRA 2.94 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 177 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIFA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 296 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIFB 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 297 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGA 3.01 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDIA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5UPKB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 588 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEA 3.11 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 49 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEB 3.11 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 49 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S46A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 None D440N,S474E Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S47A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 None D440N,S474E Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN AF-O96013-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 313 - 580 0 None None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN AF-O96013-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 313 - 580 0 None None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 2BVAA 2.3 Inactive DFGin‑BLAminus out-out out-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 587 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 2BVAB 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 301 - 587 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4L67A 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 2Q0NA 1.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 298 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 8YHKA 3.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 298 - 591 0 None None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 2J0IA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4XBUA 2.06 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 297 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDJA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474,TPO562 F461V Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDKA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474,TPO562 F461V Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIHA 1.97 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 298 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIIA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIJA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDHA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 6WLXA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 6WLYA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S48A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5UPLA 3.003 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5XVFA 2.655 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8FR Type1 300 - 588 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5XVAA 1.847 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8FU Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5XVGA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8FX Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5ZJWA 1.798 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 9EO Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 9D52A 2.449 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2R Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 9D53A 2.468 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2P Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5BMSA 2.903 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4T6 Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 2X4ZA 2.1 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii 7KC Type1 299 - 590 0 SEP474 P296G,Q297S,R298H,V299M Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4APPA 2.2 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii N53 Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4NJDA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NJD Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5I0BA 3.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 67U Type1 301 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 8AHGA 1.885 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii M4I Type1 300 - 591 0 SEP474 L310A Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 8AHHA 2.037 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii M4X Type1 300 - 591 0 SEP474 L310A Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 8AHIA 2.69 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii M56 Type1 300 - 591 0 SEP474 L310A Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 2CDZA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 23D Type1 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5VEDA 2.301 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5VEEA 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 981 Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5VEFA 1.752 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii M77 Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7CP3A 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii GC6 Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7CP4A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii GCC Type1.5_Back 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7CMBA 2.592 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G5X Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4O0VA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2OL Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4O0XA 2.483 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2OQ Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4O0YA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2OO Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGB 3.01 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK5 PAK5_HUMAN AF-Q9P286-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 441 - 708 0 None None Serine/threonine-protein kinase PAK 5
STE PAK5 PAK5_HUMAN AF-Q9P286-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 441 - 708 0 None None Serine/threonine-protein kinase PAK 5
STE PAK5 PAK5_HUMAN 8C12AAA 1.549 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 426 - 717 0 SEP602 None Serine/threonine-protein kinase PAK 5
STE PAK5 PAK5_HUMAN 2F57A 1.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 425 - 715 0 SEP602 None Serine/threonine-protein kinase PAK 5
STE PAK5 PAK5_HUMAN 2F57B 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 23D Type1 425 - 718 0 SEP602 None Serine/threonine-protein kinase PAK 5
STE PAK6 PAK6_HUMAN AF-Q9NQU5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 399 - 666 0 None None Serine/threonine-protein kinase PAK 6
STE PAK6 PAK6_HUMAN AF-Q9NQU5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 399 - 666 0 None None Serine/threonine-protein kinase PAK 6
STE PAK6 PAK6_HUMAN 2C30A 1.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 385 - 674 0 SEP560 None Serine/threonine-protein kinase PAK 6
STE PAK6 PAK6_HUMAN 4KS7A 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 7KC Type1 386 - 672 0 SEP560 None Serine/threonine-protein kinase PAK 6
STE PAK6 PAK6_HUMAN 4KS8A 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 385 - 671 0 SEP560 None Serine/threonine-protein kinase PAK 6
STE SLK SLK_HUMAN AF-Q9H2G2-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 26 - 300 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN AF-Q9H2G2-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 26 - 300 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 2JFMA 2.85 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 21 - 308 0 TPO183 None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 6HVDA 1.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo GUQ Type1 19 - 309 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 2J51A 2.1 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiio APEdist_oooo DKI Type1 21 - 308 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 2JFLA 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiio APEdist_oooo DKI Type1 21 - 308 0 TPO183,SEP189 None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 2UV2A 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oooo GVD Type1 21 - 308 0 None K25T STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 4USFA 1.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanio APEdist_nnnn 6UI Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 4USFB 1.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 6UI Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMD 2.6 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMG 2.6 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1 19 - 309 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMA 2.6 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1.5_Front 19 - 309 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMB 2.6 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1.5_Front 19 - 310 0 None None STE20-like serine/threonine-protein kinase
STE STK10 STK10_HUMAN 4USEA 2.65 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aanio APEdist_nnnn R09 Type1 24 - 316 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4USEB 2.65 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aanio APEdist_nnnn R09 Type1 24 - 316 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN AF-O94804-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 302 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN AF-O94804-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 302 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4BC6A 2.2 Inactive DFGin‑BLAminus in-out out-none nonTYR APEdihe_aannn APEdist_nnnn XZN Type1 24 - 316 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 2J7TA 2.0 Inactive DFGin‑BLAminus in-none out-out nonTYR APEdihe_aaiii APEdist_nnoo 274 Type1 25 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5OWRA 2.3 Inactive DFGin‑BLAminus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 1N1 Type1 23 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6HXFA 2.09 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiio APEdist_iioo R70 Type1 24 - 313 0 TPO185,SEP191,TPO208 None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6HXFB 2.09 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiio APEdist_iioo R70 Type1 24 - 314 0 TPO185,SEP191,TPO208 None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6HXFC 2.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii R70 Type1 24 - 312 0 TPO185,SEP191,TPO208 None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6HXFD 2.09 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiio APEdist_iioo R70 Type1 23 - 312 0 TPO185,SEP191,TPO208 None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 7QGPA 1.9 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaiio APEdist_iioo DJ8 Type1.5_Front 23 - 313 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5AJQA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nooo DB8 Type1 24 - 312 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5AJQB 2.2 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aanii APEdist_nnnn DB8 Type1 25 - 312 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6GTTA 2.25 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aanio APEdist_nnnn B96 Type2 18 - 316 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6EIMA 1.43 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo B6E Type2 26 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6EIMB 1.43 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo B6E Type2 23 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4AOTA 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nnno GW8 Type1 18 - 314 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4AOTB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nnoo GW8 Type1 18 - 314 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4USDA 3.05 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno R09 Type1 24 - 314 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4USDB 3.05 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno R09 Type1 24 - 314 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4EQUA 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo G6I Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4EQUB 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nooo G6I Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YA 2.56 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YB 2.56 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5OWQA 2.7 Inactive None‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn 38O Type1 30 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5OWQB 2.7 Inactive None‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 38O Type1 32 - 317 0 None None Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 3A7HA 1.96 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7HB 1.96 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 17 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7JA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMLA 1.882 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 30 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN AF-Q9Y6E0-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 294 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN AF-Q9Y6E0-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 294 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7FA 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7GA 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7GB 2.0 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4U8ZA 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3FE Type1 24 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4W8DA 1.77 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3JA Type1 24 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4W8EA 1.79 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3JB Type1 24 - 311 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7IA 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3CKXA 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 32 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMMA 1.852 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 35R Type1 18 - 309 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMNA 2.091 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DB8 Type1 27 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMOA 1.898 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 34L Type1 18 - 309 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMPA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DKI Type1 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMQA 1.769 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 34U Type1 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMSA 1.883 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 1N1 Type1 27 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMTA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H1N Type1 27 - 311 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMUA 1.546 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SKE Type1 24 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMVA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 34W Type1 19 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMXA 1.882 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H8H Type1 24 - 311 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMYA 1.883 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMZA 1.88 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QNAA 1.849 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X11 Type1 27 - 311 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QO9A 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 627 Type1 30 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QO9B 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 627 Type1 25 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMWA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KS1 Type1.5_Back 24 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3ZHPC 2.9 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 31 - 300 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3ZHPD 2.9 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaiii APEdist_nooo No_ligand No_ligand 32 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8BZIA 1.72 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SJL Type1.5_Back 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8BZJA 2.52 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SJX Type1.5_Back 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B30A 2.1 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 59T Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B31A 1.8 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQ8 Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B32A 1.75 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQQ Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B33A 1.9 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQE Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B34A 2.1 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQK Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B35A 2.4 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQB Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B35B 2.4 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQB Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8BZJB 2.52 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn SJX Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLRA 1.85 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYN Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLRB 1.85 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYN Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLSA 1.61 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYH Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLTA 1.47 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VZ2 Type1.5_Front 25 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLQA 1.64 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo VY0 Type1 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4O27B 3.185 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 30 - 309 0 None T190E Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3CKWA 1.96 Inactive None‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni No_ligand No_ligand 32 - 310 0 None None Serine/threonine-protein kinase 24
STE STK25 STK25_HUMAN AF-O00506-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 278 0 None None Serine/threonine-protein kinase 25
STE STK25 STK25_HUMAN AF-O00506-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 278 0 None None Serine/threonine-protein kinase 25
STE STK25 STK25_HUMAN 2XIKA 1.97 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii J60 Type1 3 - 292 0 TPO174 None Serine/threonine-protein kinase 25
STE STK25 STK25_HUMAN 7Z4VA 1.644 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii IB5 Type1 3 - 293 0 TPO174 None Serine/threonine-protein kinase 25
STE STK25 STK25_HUMAN 4NZWB 3.583 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnni J60 Type1 11 - 292 0 None D158A Serine/threonine-protein kinase 25
STE STK26 STK26_HUMAN AF-Q9P289-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 282 0 None None Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN AF-Q9P289-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 282 0 None None Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 7B36C 2.107 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo 59T Type1.5_Back 17 - 299 0 None None Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 7B36A 2.107 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 59T Type1.5_Front 18 - 300 0 None None Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 3GGFA 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo GVD Type1 17 - 300 0 None None Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 3GGFB 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo GVD Type1 18 - 297 0 None None Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 4FZFB 3.64 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo DKI Type1 18 - 297 0 None D162A Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 4FZAB 3.15 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 18 - 297 0 None D162A Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 4FZDB 3.25 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 18 - 297 0 None D162A Serine/threonine-protein kinase 26
STE STK3 STK3_HUMAN 5DH3B 2.468 Inactive DFGin‑ABAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 18 - 302 0 TPO174,TPO180 None Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN AF-Q13188-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 286 0 None None Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN AF-Q13188-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 286 0 None None Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 8A66A 1.901 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5BS Type1 24 - 303 0 TPO180 None Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 8A66B 1.901 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5BS Type1 18 - 304 0 TPO174,TPO180,TPO268 None Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 5DH3A 2.468 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 19 - 307 0 TPO174,TPO180 None Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 6AO5A 2.955 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioo APEdist_nooo ANP ATPlike 28 - 488 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDA 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 16 - 488 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDB 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 10 - 488 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDC 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 12 - 490 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDD 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 11 - 489 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LG4A 2.42 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 18 - 308 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LG4B 2.42 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 18 - 308 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LG4C 2.42 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 18 - 307 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LG4E 2.42 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 18 - 308 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LG4F 2.42 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 18 - 310 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LG4D 2.42 Inactive None‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 26 - 308 0 None D146N Serine/threonine-protein kinase 3
STE STK39 STK39_HUMAN AF-Q9UEW8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 55 - 345 0 None None STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_HUMAN AF-Q9UEW8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 55 - 345 0 None None STE20/SPS1-related proline-alanine-rich protein kinase
STE STK4 STK4_HUMAN 6YATA 2.58 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3FX, OJ5 Allosteric, Type1 18 - 308 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN AF-Q13043-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 289 0 None None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN AF-Q13043-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 289 0 None None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 3COMA 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 3COMB 2.2 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 300 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 8A5JA 2.123 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 28 - 309 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 8PAVA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XOZ Type1 23 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 8PAVB 1.9 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii XOZ Type1 14 - 299 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 8PAWA 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XQL Type1 23 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 8PAWB 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XQL Type1 14 - 299 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 6YATB 2.58 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii OJ5 Type1 29 - 307 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 9IICA 2.78 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 11 - 308 0 None K59R Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 9IICB 2.78 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 11 - 311 0 None K59R Serine/threonine-protein kinase 4
STE STK4 STK4_HUMAN 8A5JB 2.123 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 32 - 309 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
STE STRADA STRAA_HUMAN 2WTKB 2.65 Pseudo DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ANP ATPlike 61 - 431 0 None None STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 2WTKE 2.65 Pseudo DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaoai APEdist_iooo ANP ATPlike 60 - 431 0 None None STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 3GNIB 2.35 Pseudo DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaoai APEdist_iooo ATP ATPlike 60 - 431 0 None None STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 8VSUB 2.86 Pseudo DFGin‑None out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ADP ATPlike 60 - 401 0 None None STE20-related kinase adapter protein alpha
STE TAOK1 TAOK1_HUMAN AF-Q7L7X3-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 20 - 289 0 None None Serine/threonine-protein kinase TAO1
STE TAOK1 TAOK1_HUMAN AF-Q7L7X3-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 20 - 289 0 None None Serine/threonine-protein kinase TAO1
STE TAOK2 TAOK2_HUMAN AF-Q9UL54-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 20 - 289 0 None None Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_HUMAN AF-Q9UL54-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 20 - 289 0 None None Serine/threonine-protein kinase TAO2
STE TAOK3 TAOK3_HUMAN 6BDNA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 8 - 314 0 None R2A,K3A Serine/threonine-protein kinase TAO3
STE TAOK3 TAOK3_HUMAN AF-Q9H2K8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 285 0 None None Serine/threonine-protein kinase TAO3
STE TAOK3 TAOK3_HUMAN AF-Q9H2K8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 285 0 None None Serine/threonine-protein kinase TAO3
STE TNIK TNIK_HUMAN 7XZRB 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 12 - 312 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN AF-Q9UKE5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN AF-Q9UKE5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 6RA5B 2.9 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 14 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 7XZQA 2.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 11 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 8ZMLB 2.489 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1D8H Type1 10 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 6RA5A 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JWE Type1 12 - 309 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 6RA7A 1.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JWK Type1 13 - 314 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 8WM0A 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5AX9A 2.4 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 4KT Type1 12 - 307 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5AX9B 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 4KT Type1 13 - 307 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5AX9C 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoii APEdist_nnno 4KT Type1 12 - 309 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 2X7FA 2.8 Inactive DFGin‑BLAminus in-none out-out nonTYR APEdihe_aaini APEdist_nnno 824 Type1 15 - 313 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 2X7FB 2.8 Inactive DFGin‑BLAminus in-none out-out nonTYR APEdihe_aaioi APEdist_nnno 824 Type1 13 - 313 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 2X7FC 2.8 Inactive DFGin‑BLAminus in-none out-none nonTYR APEdihe_aanni APEdist_nnnn 824 Type1 14 - 313 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 2X7FD 2.8 None DFGin‑BLAminus in-none none-none nonTYR APEdihe_aanni APEdist_nnnn 824 Type1 17 - 306 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 8ZMLA 2.489 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1D8H Type1.5_Back 11 - 312 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 7XZRA 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP Type1.5_Front 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5CWZA 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oioo No_ligand No_ligand 11 - 307 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5CWZB 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 11 - 307 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5CWZC 2.9 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 15 - 308 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5D7AA 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oioo 58C Type1 11 - 310 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5D7AB 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oioo 58C Type1 11 - 307 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 5D7AC 2.9 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 58C Type1 13 - 310 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 2X7FE 2.8 Inactive DFGin‑None in-none none-none nonTYR APEdihe_aanni APEdist_nnnn 824 Type1 14 - 309 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 8X88A 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo No_ligand No_ligand 15 - 311 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 8X88B 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None TRAF2 and NCK-interacting protein kinase

STE / All / All

Total number of chains: 839
Active chains: 199
Total number of genes: 48
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 435 51.8% AF-Q02750-K1A
DFGin BLBplus 149 17.8% 9AXXA
DFGout None 61 7.3% 9N7RA
DFGin None 52 6.2% 9H8FA
DFGin BLBminus 33 3.9% 4LGDA
DFGout BBAminus 33 3.9% 6EIMB
None None 24 2.9% 7F2XA
DFGin ABAminus 18 2.1% 6NFYB
DFGinter None 14 1.7% 4U3YA
DFGin BLAplus 9 1.1% 9N4UB
DFGin BLBtrans 9 1.1% 3DAKD
DFGinter BABtrans 2 0.2% 2CLQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MKK5 M2K5_ARATH 7XBRA 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 63 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRC 3.2 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 64 - 329 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRD 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 68 - 329 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRF 3.2 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 64 - 327 0 SEP66,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRH 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 65 - 329 0 SEP66,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRB 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 65 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRE 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 65 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRG 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 64 - 327 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE DSOR1 DSOR1_DROME 8BW9C 3.32 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 81 - 384 0 None None Dual specificity mitogen-activated protein kinase kinase dSOR1 Drosophila melanogaster
STE MAP2K1 MP2K1_HUMAN AF-Q02750-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 369 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN AF-Q02750-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 369 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8CHFE 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8CHFF 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQDA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQIA 1.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3C 2.9 Inactive DFGin‑BLBplus out-none none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6U2GA 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6V2WB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNEA 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 63 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNED 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 66 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8DGSB 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type1 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4AN3A 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onno ATP, 5Y0 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4AN9A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onoo ACP, 2P7 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3SLSA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3SLSB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B3MA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B3MB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B7RA 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, T1K ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B7RB 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T1K ATPlike, Type3 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B94A 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, T3W ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B94B 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T3W ATPlike, Type3 41 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B9LA 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B9LB 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3ORNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3OR ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3OS3A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 3OS ATPlike, Type3 62 - 378 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3WIGA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3DV3A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ATP, MEK ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3MBLA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LSG ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3PP1A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, IZG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQBA 2.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, LUG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4U80A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ANP, 3EX ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 1S9JA 2.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, BBM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3DY7A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ATP, 1CX ATPlike, Type3 62 - 364 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3E8NA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo ATP, VRA ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3VVHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3VVHB 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3VVHC 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4ARKA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, M3K ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4LMNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNEE 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQGA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP, 4BM ATPlike, Type3 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7UMBC 3.231 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, U9F ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6PP9B 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, LCJ ATPlike, Type3 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0VB 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0WB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOA ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0XB 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0YB 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 43 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0ZB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8DGTB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type3 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6NYBB 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LCJ ATPlike, Type3 56 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9MMPB 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9MMQB 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9MMRB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9MMSB 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 63 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNEH 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ACP, 573, 573 ATPlike, Type3, Allosteric 66 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXMC 2.42 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type1 43 - 376 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7PQVA 2.13 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 80C Type1 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3ZLSA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 92P Type1 39 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3ZLXA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5EZ Type1 39 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3ZM4A 2.37 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 22T Type1 40 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5BX0A 2.93 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 4W5 Type1 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7XNCA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo GIK Type1 37 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3ZLYA 2.11 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo YSO Type1 40 - 382 0 None S298N,S299N,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5EYMA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 41 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5EYMB 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 41 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQFA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo KSA Type1 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0UB 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type1 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3ZLWA 2.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo MT8 Type1 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXHA 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 39 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXHB 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXMA 2.42 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXXA 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 41 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXXC 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 37 - 378 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AYAB 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 42 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AYAD 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno A1AHE, ANP Type1, ATPlike 39 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AY7B 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 33 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0UH 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VB 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VH 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7XLPA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno FZC Type1.5_Back 37 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7MFDB 3.66 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU Type3 52 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O2ZB 3.83 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU Type3 52 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXAB 4.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 52 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXAD 4.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 59 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXCB 4.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 52 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXCD 4.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1AHE Type3 59 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0UD 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type3 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0UF 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type3 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4AN2A 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo EUI, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4ANBA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YQY, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 2P55A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo MRA, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4U7ZA 2.805 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo 3EW, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4U81A 2.701 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3EY, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3V01A 2.705 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3V0, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3V04A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo V04, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQCA 1.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 3BM, AGS Type3, ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 5BM, ADP Type3, ATPlike 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9ECUB 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1BIS, ANP Type3, ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXYB 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type3, ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VD 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VF 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0TB 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo 3EW, ANP Type3, ATPlike 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0UB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo QO7, ANP Type3, ATPlike 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3B 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3D 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8YP4A 2.35 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo WNT Type1 34 - 384 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3A 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5HZEA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo E62 Type1 43 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8YP4B 2.35 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn WNT Type1 43 - 383 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7F2XA 2.007 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 45 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3W8QA 2.2 Inactive None‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo AGS ATPlike 39 - 382 0 None T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6Q0TC 5.7 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6Q0JC 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6Q0JD 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K2 MP2K2_HUMAN AF-P36507-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 64 - 377 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
STE MAP2K2 MP2K2_HUMAN AF-P36507-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 64 - 377 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
STE MAP2K2 MP2K2_HUMAN 1S9IA 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ATP, 5EA ATPlike, Type3 60 - 393 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
STE MAP2K2 MP2K2_HUMAN 1S9IB 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ATP, 5EA ATPlike, Type3 59 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
STE MAP2K3 MP2K3_HUMAN AF-P46734-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 56 - 333 0 None None Dual specificity mitogen-activated protein kinase kinase 3 Homo sapiens
STE MAP2K3 MP2K3_HUMAN AF-P46734-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 56 - 333 0 None None Dual specificity mitogen-activated protein kinase kinase 3 Homo sapiens
STE MAP2K4 MP2K4_HUMAN AF-P45985-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 94 - 375 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN AF-P45985-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 94 - 375 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3ALNA 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 83 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3ALNB 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 84 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3ALOA 2.6 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoao APEdist_oooo ANP ATPlike 95 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 8YP5A 2.5 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoai APEdist_oooo 1FM Type1 80 - 392 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3ALNC 2.3 Inactive None‑None none-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 100 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3VUTA 3.5 Inactive None‑None none-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 142 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3VUTB 3.5 Inactive None‑None out-na out-out nonTYR APEdihe_aannn APEdist_iooo No_ligand No_ligand 80 - 373 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K5 MP2K5_HUMAN AF-Q13163-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 158 - 427 0 None None Dual specificity mitogen-activated protein kinase kinase 5 Homo sapiens
STE MAP2K5 MP2K5_HUMAN AF-Q13163-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 158 - 427 0 None None Dual specificity mitogen-activated protein kinase kinase 5 Homo sapiens
STE MAP2K6 MP2K6_HUMAN AF-P52564-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 45 - 322 0 None None Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN AF-P52564-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 45 - 322 0 None None Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8A8MB 4.0 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn AP2 Type1 38 - 334 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3ENMA 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 46 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3ENMB 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 49 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3ENMC 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 48 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3ENMD 2.35 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 45 - 332 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8P7JA 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8P7JB 2.4 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8PM3A 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8PM3B 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8PM3C 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8PM3D 2.0 Inactive DFGout‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3FMEA 2.26 Inactive None‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno STU Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3VN9A 2.6 Inactive None‑None out-na out-out nonTYR APEdihe_aaiao APEdist_oooo ANK Type1 44 - 334 0 None None Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6QFLA 2.2 Inactive DFGin‑ABAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6QFTA 2.7 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aanai APEdist_nnnn J0B Type1 102 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6QG4A 2.3 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn J0E Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6QG7A 2.1 Inactive DFGin‑ABAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 6HL Type1 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6QHOA 2.7 Inactive DFGin‑ABAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn J3H Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN AF-O14733-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 112 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN AF-O14733-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 112 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 2DYLA 2.45 None DFGin‑BLAminus in-na none-none nonTYR APEdihe_aanai APEdist_nnnn No_ligand No_ligand 103 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG1A 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 86 - 404 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG1B 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 93 - 404 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG1C 2.22 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 86 - 405 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5Z1DA 2.28 None DFGin‑BLAminus in-na none-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG3A 2.05 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn 6HF Type1 103 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6IB0A 2.6 Inactive DFGin‑BLAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi H8Z Type1 101 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6QHRA 2.52 Inactive DFGin‑BLAminus in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi J3N Type1 111 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVIA 1.95 Inactive DFGin‑BLAplus in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2GI Type1.5_Front 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVJA 2.35 Inactive DFGin‑BLBplus in-na none-none nonTYR APEdihe_aaiai APEdist_nnni 24N Type1.5_Front 102 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5B2MA 3.06 Inactive DFGin‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 105 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVLA 2.9 Inactive DFGin‑None in-na none-out nonTYR APEdihe_aaiai APEdist_nnoi 1XZ Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVMA 2.9 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni 21I Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVNA 2.9 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 2I8 Type1 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 9HZ0A 2.25 Inactive DFGin‑None in-na in-none nonTYR APEdihe_aaiai APEdist_nnni A1IY7 Type1 101 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVKA 2.05 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2I5 Type1.5_Back 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6IB2A 2.1 Inactive DFGin‑None in-na none-none nonTYR APEdihe_aannn APEdist_nnnn 862 Type1.5_Front 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG7A 2.2 Inactive DFGout‑BBAminus out-na none-out nonTYR APEdihe_aanao APEdist_nnnn OQ2 Type2 102 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG7B 2.2 Inactive DFGout‑BBAminus out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ2 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YZ4A 1.7 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno 1E8 Allosteric 101 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5Y8UA 2.92 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnoo No_ligand No_ligand 103 - 402 0 None C260S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5Y90A 1.3 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 103 - 419 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5B2LA 2.1 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni No_ligand No_ligand 104 - 403 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YFZA 1.9 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 100 - 405 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6QFRA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5B2KA 2.75 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 104 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG0A 2.0 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7CBXA 2.061 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn FU6 Type1 103 - 402 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5Z1EA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 419 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG4A 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn SU9 Type1 103 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG5A 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn IHH Type1 101 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 3WZUA 3.01 Inactive DFGout‑None none-na none-out nonTYR APEdihe_aaoai APEdist_nnno 1FM Type1 104 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG6A 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG6B 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 104 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG2A 2.0 Inactive None‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn 1E8, 8E8 Allosteric, Type1.5_Front 102 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP3K1 M3K1_HUMAN AF-Q13233-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1235 - 1512 0 None None Mitogen-activated protein kinase kinase kinase 1 Homo sapiens
STE MAP3K1 M3K1_HUMAN AF-Q13233-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1235 - 1512 0 None None Mitogen-activated protein kinase kinase kinase 1 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4IDTA 2.4 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi T28 Type1 333 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4DN5A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_noii AGS ATPlike 332 - 675 0 None S549D Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4DN5B 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_noii AGS ATPlike 333 - 675 0 None S549D Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 8YHWA 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 8YHWB 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 8YHWC 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 8YHWD 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS, PE8 ATPlike, Allosteric 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN AF-Q99558-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 391 - 661 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN AF-Q99558-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 391 - 661 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4G3DA 2.9 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_ioii No_ligand No_ligand 332 - 672 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4G3DB 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 332 - 666 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4G3DD 2.9 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii No_ligand No_ligand 338 - 657 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4G3DE 2.9 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanin APEdist_nnii No_ligand No_ligand 332 - 663 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 6WPPA 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi PZ4 Type1 344 - 674 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 6WPPB 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi PZ4 Type1 343 - 674 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 6Z1QAAA 2.42 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi Q58 Type1 332 - 676 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 6Z1QBBB 2.42 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi Q58 Type1 332 - 677 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 6Z1TAAA 2.31 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi Q55 Type1 334 - 676 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 6Z1TBBB 2.31 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi Q55 Type1 332 - 677 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4IDTB 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi T28 Type1 334 - 677 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4IDVA 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 13V Type1.5_Back 331 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4IDVB 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 13V Type1.5_Back 331 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4IDVC 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 13V Type1.5_Back 331 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4IDVD 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 13V Type1.5_Back 331 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K15 M3K15_HUMAN AF-Q6ZN16-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 637 - 916 0 None None Mitogen-activated protein kinase kinase kinase 15 Homo sapiens
STE MAP3K15 M3K15_HUMAN AF-Q6ZN16-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 637 - 916 0 None None Mitogen-activated protein kinase kinase kinase 15 Homo sapiens
STE MAP3K19 M3K19_HUMAN AF-Q56UN5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1053 - 1328 0 None None Mitogen-activated protein kinase kinase kinase 19 Homo sapiens
STE MAP3K19 M3K19_HUMAN AF-Q56UN5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1053 - 1328 0 None None Mitogen-activated protein kinase kinase kinase 19 Homo sapiens
STE MAP3K2 M3K2_HUMAN AF-Q9Y2U5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 348 - 619 0 None None Mitogen-activated protein kinase kinase kinase 2 Homo sapiens
STE MAP3K2 M3K2_HUMAN AF-Q9Y2U5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 348 - 619 0 None None Mitogen-activated protein kinase kinase kinase 2 Homo sapiens
STE MAP3K2 M3K2_HUMAN 9P6AA 2.4 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_oooo 0LI Type2 351 - 617 0 None None Mitogen-activated protein kinase kinase kinase 2 Homo sapiens
STE MAP3K2 M3K2_HUMAN 9P6AB 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnoo 0LI Type2 347 - 618 0 None None Mitogen-activated protein kinase kinase kinase 2 Homo sapiens
STE MAP3K3 M3K3_HUMAN AF-Q99759-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 354 - 626 0 None None Mitogen-activated protein kinase kinase kinase 3 Homo sapiens
STE MAP3K3 M3K3_HUMAN AF-Q99759-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 354 - 626 0 None None Mitogen-activated protein kinase kinase kinase 3 Homo sapiens
STE MAP3K4 M3K4_HUMAN AF-Q9Y6R4-K1A -1.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii No_ligand No_ligand 1335 - 1608 0 None None Mitogen-activated protein kinase kinase kinase 4 Homo sapiens
STE MAP3K4 M3K4_HUMAN AF-Q9Y6R4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1335 - 1608 0 None None Mitogen-activated protein kinase kinase kinase 4 Homo sapiens
STE MAP3K5 M3K5_HUMAN AF-Q99683-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 665 - 946 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN AF-Q99683-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 665 - 946 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BICB 2.62 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnoi No_ligand No_ligand 670 - 941 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 8QGYB 3.71 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6OYTA 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn NJV Type1 667 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6OYTB 2.824 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnno NJV Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6OYTC 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn NJV Type1 671 - 938 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6OYTD 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni NJV Type1 667 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5UOXA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GY Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5UOXB 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GY Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5UP3A 2.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GS Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5UP3B 2.95 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 8GS Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5V19A 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V4 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5V19B 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5V24A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 8V7 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5V24B 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V7 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 3VW6A 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi IM6 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 3VW6B 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi IM6 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5UORA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 8GV Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5UORB 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GV Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VILA 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VILB 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VILD 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VIOA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VIOB 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VIOD 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6XIHA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi V3S Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6XIHB 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnni V3S Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6E2MA 2.253 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KK7 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6E2MB 2.253 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi KK7 Type1 671 - 940 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6E2NA 2.098 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KK8 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6E2NB 2.098 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii KK8 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6E2OA 2.389 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii S0L Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6E2OB 2.389 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi S0L Type1 671 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6VREA 2.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi RFG Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6VREB 2.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi RFG Type1 669 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6OYWA 2.603 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6OYWB 2.603 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi NKJ Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6OYWC 2.603 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 6OYWD 2.603 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BIBA 2.43 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi IEO Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BIBB 2.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi IEO Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BICA 2.62 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE4 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BIDA 2.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE8 Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BIDB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE8 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BIEA 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi IE6 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BIEB 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE6 Type1 670 - 941 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BF2A 2.11 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BF2B 2.11 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_nnoi STU Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BHNA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BH9 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BHNB 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi BH9 Type1 670 - 938 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 7MU6A 2.165 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi A1AWT Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 7MU6B 2.165 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii A1AWT Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 7MU7A 2.298 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi RFG Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 7MU7B 2.298 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi RFG Type1 669 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VIOC 2.84 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 5VILC 2.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 2CLQA 2.3 Inactive DFGinter‑BABtrans out-out in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 2CLQB 2.3 Inactive DFGinter‑BABtrans in-none in-out nonTYR APEdihe_aaiii APEdist_nooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 8QGYA 3.71 Inactive DFGout‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K6 M3K6_HUMAN AF-O95382-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 635 - 914 0 None None Mitogen-activated protein kinase kinase kinase 6 Homo sapiens
STE MAP3K6 M3K6_HUMAN AF-O95382-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 635 - 914 0 None None Mitogen-activated protein kinase kinase kinase 6 Homo sapiens
STE MAP3K8 M3K8_HUMAN AF-P41279-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 119 - 396 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN AF-P41279-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 119 - 396 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN 4Y83A 2.89 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 49B Type1 73 - 389 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN 4Y83B 2.89 Inactive DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 49B Type1 73 - 390 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN 4Y83C 2.89 Inactive DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 49B Type1 74 - 389 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN 4Y85A 2.33 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 499 Type1 73 - 390 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN 4Y85B 2.33 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 499 Type1 73 - 390 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN 4Y85C 2.33 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 499 Type1 73 - 390 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN 5IU2A 2.7 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 6DA Type1 73 - 389 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP3K8 M3K8_HUMAN 5IU2B 2.7 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiii APEdist_iiii 6DA Type1 73 - 389 0 None None Mitogen-activated protein kinase kinase kinase 8 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6NFYA 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi B49 Type1 10 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6NFYB 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioi B49 Type1 10 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6CQDA 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 2 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6CQDB 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN AF-Q92918-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 282 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN AF-Q92918-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 282 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7KACB 1.85 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo W9D Type1 7 - 294 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0MA 1.93 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo YK1 Type1 2 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0MB 1.93 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo YK1 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7R9NA 1.5 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7R9NB 1.5 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7R9PA 2.27 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2WI Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7R9PB 2.27 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2WI Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7R9TA 2.0 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2TR Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7R9TB 2.0 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 2TR Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZTA 1.69 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1E Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZTB 1.69 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1E Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZUA 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZUB 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nooo A1A1D Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZUC 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 2 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZUD 1.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1D Type1 8 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZWA 1.59 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo A1A1C Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZWB 1.59 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1C Type1 5 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZXA 1.464 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1B Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9D00A 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9D00B 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9D00C 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9D00D 1.951 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1A Type1 4 - 292 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9BIKB 2.25 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APO Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9BJ1A 2.18 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APR Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9NACA 1.45 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWM Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9NACB 1.45 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aanoi APEdist_nnnn A1BWM Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9NBSA 1.8 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BW4 Type1 3 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9NBSB 1.8 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BW4 Type1 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9NC2A 1.5 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 3 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9NC2B 1.5 Inactive DFGin‑BLAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo F97 Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6NFZA 2.966 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 7 - 292 0 TPO165,SEP171 None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6NFZB 2.966 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 5 - 292 0 TPO165,SEP171 None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FH4A 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FH4B 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FH4C 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FH4D 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno XXF Type1 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FJZA 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 3 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FJZB 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FJZC 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FJZD 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno Y3I Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FJZE 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo Y3I Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FJZF 1.897 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3I Type1 9 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FKOA 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3O Type1 4 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FKOB 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FKOC 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FKOD 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno Y3O Type1 5 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FKOE 2.104 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo Y3O Type1 9 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L24A 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aannn APEdist_onnn XHV Type1 7 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L24B 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo XHV Type1 7 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L24C 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanii APEdist_ooon XHV Type1 8 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L24D 2.68 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XHV Type1 8 - 292 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9CZXB 1.464 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1A1B, A1A1B Type1, Allosteric 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9BJ1B 2.18 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo A1APQ Type1.5_Back 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7KACA 1.85 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno W9D Type1 7 - 304 0 None L221D,F225E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9H8DA 1.641 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITC Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9H8EA 1.631 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITA Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9H8FA 1.393 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo A1ITB Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9QT6A 1.76 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo A1JAF Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6NG0A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo B49 Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6CQFA 2.246 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo F97 Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7R9LA 2.332 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo 2YE Type1 7 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L26A 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L26B 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L26C 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L26D 2.3 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno XHM Type1 8 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L25A 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 7 - 294 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7L25B 1.85 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo XHS Type1 6 - 293 0 None S171A,G191C Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7SIUA 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oioo 9ID Type1.5_Back 5 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7SIUB 1.786 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9ID Type1.5_Back 16 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9BI8A 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9BI8B 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9N9XA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9N9XB 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0KA 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0KB 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 8 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0KC 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 8 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0KD 2.01 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK7 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0LA 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0LB 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 7 - 291 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0LC 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 7M0LD 2.43 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YK4 Type1 6 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8XN7A 2.65 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo A1LVT Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8XN7B 2.65 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo A1LVT Type1 6 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6NG0B 2.05 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo B49 Type1 7 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9BIKA 2.25 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_oooo A1APO Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9N7RB 2.13 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWC Type1 8 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9N7RA 2.13 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo A1BWC, A1BWC, A1BWC, A1BWC Allosteric, Allosteric, Type1, Type3 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PAUA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PAUB 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PASA 2.7 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 8 - 295 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PASB 2.7 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8CDWA 1.941 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8CIJA 2.821 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni USF Type1 14 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PARA 2.0 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XON Type1 7 - 294 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FKOF 2.104 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 57 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6CQEA 1.886 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 4 - 293 0 None S171A Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6CQEB 1.886 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 5 - 293 0 None S171A Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8CDWB 1.941 Inactive None‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 9 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K2 M4K2_HUMAN AF-Q12851-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 8 - 281 0 None None Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens
STE MAP4K2 M4K2_HUMAN AF-Q12851-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 8 - 281 0 None None Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens
STE MAP4K3 M4K3_HUMAN AF-Q8IVH8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 8 - 281 0 None None Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens
STE MAP4K3 M4K3_HUMAN AF-Q8IVH8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 8 - 281 0 None None Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens
STE MAP4K3 M4K3_HUMAN 5J5TA 2.85 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo 6G2 Type1 13 - 314 0 TPO145 S170A Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens
STE MAP4K4 M4K4_HUMAN AF-O95819-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN AF-O95819-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 8V5IA 2.18 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo A1AAA Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBPA 2.27 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 2QU Type1 13 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U44A 2.43 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iioo 3D9 Type1 12 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U45A 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 3DC Type1 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4ZK5A 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 4P4 Type1 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U40A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U42A 2.504 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 3C8 Type1 16 - 310 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4ZP5A 2.29 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 4QG Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5DI1A 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 5DF Type1 13 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5J95A 2.5 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 6HH Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4RVTA 2.4 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_oooo 3XM Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBOA 2.1 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 2QV Type1 16 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBQA 2.19 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_iioo 2QT Type1 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U41A 2.2 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 3C8 Type1 16 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U43A 2.18 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo 3D8 Type1 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5W5QA 2.33 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9X4 Type1.5_Back 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U3ZA 2.09 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U3YA 1.45 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U3YB 1.45 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 8 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U3ZB 2.09 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4ZP5B 2.29 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5DI1B 2.9 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5J95B 2.5 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 8V5IB 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4RVTB 2.4 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBOB 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBPB 2.27 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBQB 2.19 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U40B 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U41B 2.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U43B 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U44B 2.43 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U45B 2.58 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4ZK5B 2.89 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5W5QB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U42B 2.504 Inactive None‑None none-none none-out nonTYR APEdihe_aaioi APEdist_oooo 3C8 Type1 17 - 310 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K5 M4K5_HUMAN AF-Q9Y4K4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 285 0 None None Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens
STE MAP4K5 M4K5_HUMAN AF-Q9Y4K4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 285 0 None None Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens
STE MINK1 MINK1_HUMAN AF-Q8N4C8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Misshapen-like kinase 1 Homo sapiens
STE MINK1 MINK1_HUMAN AF-Q8N4C8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Misshapen-like kinase 1 Homo sapiens
STE MYO3A MYO3A_HUMAN AF-Q8NEV4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 295 0 None None Myosin-IIIa Homo sapiens
STE MYO3A MYO3A_HUMAN AF-Q8NEV4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 295 0 None None Myosin-IIIa Homo sapiens
STE MYO3B MYO3B_HUMAN AF-Q8WXR4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 301 0 None None Myosin-IIIb Homo sapiens
STE MYO3B MYO3B_HUMAN AF-Q8WXR4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 301 0 None None Myosin-IIIb Homo sapiens
STE NRK NRK_HUMAN AF-Q7Z2Y5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 321 0 None None Nik-related protein kinase Homo sapiens
STE NRK NRK_HUMAN AF-Q7Z2Y5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 321 0 None None Nik-related protein kinase Homo sapiens
STE OXSR1 OXSR1_HUMAN AF-O95747-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 299 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN AF-O95747-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 9 - 299 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 3DAKA 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ANP ATPlike 6 - 295 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 3DAKB 2.25 Inactive DFGin‑BLBtrans out-out out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 6 - 295 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 3DAKC 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 7 - 295 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 3DAKD 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nooo ANP ATPlike 7 - 295 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWIB 2.15 Inactive DFGin‑BLBtrans out-out out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 9 - 292 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWIC 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo ANP ATPlike 9 - 292 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWID 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 6 - 298 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWIA 2.15 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 13 - 292 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE PAK1 PAK1_HUMAN 9N48B 1.85 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1BV1 Type1 255 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 3Q53A 2.09 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 250 - 541 0 TPO423 K299R,L516I Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 3Q4ZA 1.887 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 251 - 545 0 None S259I,K299R,D389N,L516I Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN AF-Q13153-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 262 - 529 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN AF-Q13153-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 262 - 529 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZLOB 2.5 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 253 - 543 0 TPO423 None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 3Q52A 1.801 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 250 - 542 0 TPO423 K299R,L516I Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 1YHWA 1.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 541 0 None K299R Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 8X5ZA 1.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 543 0 TPO423 K299R,E503D Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 1YHVA 1.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 541 0 None K299R,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4O0RB 2.4 Inactive DFGin‑BLAminus out-out none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 249 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 3FXZA 1.64 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii FLL Type1 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 3FY0A 2.35 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii DW1 Type1 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4DAWA 2.0 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii 0H2 Type1 249 - 542 0 TPO423 K299R Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZY4A 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4T3 Type1 249 - 541 0 None D389N Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZY5A 2.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4T5 Type1 251 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZY6A 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4T6 Type1 251 - 542 0 None D389N Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 6B16A 2.285 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii C7Y Type1 251 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 7VTOA 2.59 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 107 Type1 257 - 542 0 TPO423 None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 2HY81 2.0 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii 1ST Type1 249 - 541 0 None K299R,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D4XA 1.847 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2S Type1 252 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D50A 1.898 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2T Type1 250 - 544 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5DEWA 1.9 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 59N Type1 250 - 544 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D4VA 1.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2P Type1 252 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D4WA 2.218 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2Q Type1 252 - 544 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D4YA 1.847 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2S Type1 252 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4O0RA 2.4 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 7KC Type1 249 - 541 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5KBQA 2.58 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii IPV Type1 254 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5KBRA 2.36 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii IPW Type1 255 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4P90A 2.49 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 2K0 Type1 250 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9N48A 1.85 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BV1 Type1 249 - 545 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9NBXA 2.15 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BW5 Type1 249 - 541 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4EQCA 2.01 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii XR1 Type1.5_Back 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5DEYA 2.1 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 59T Type1.5_Back 250 - 544 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4O0TA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2OL Type1.5_Back 251 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5IMEA 2.217 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 6BZ Type1.5_Back 251 - 545 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9N4UA 1.77 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1BV8 Type1.5_Back 249 - 545 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5DFPA 2.2 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii 59U Type1.5_Front 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 1F3MC 2.3 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaioo APEdist_oooo No_ligand No_ligand 249 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 1F3MD 2.3 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 249 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZY6B 2.15 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo 4T6 Type1 255 - 542 0 None D389N Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9N4UB 1.77 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaiio APEdist_nnno A1BV8 Type1 255 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D4XB 1.847 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaiio APEdist_nnno A1A2S Type1 256 - 543 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D4YB 1.847 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaiio APEdist_nnno A1A2S Type1 256 - 543 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZY4B 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_oooo 4T3 Type1 249 - 541 0 None D389N Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZY5B 2.35 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_oooo 4T5 Type1 255 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 6B16B 2.285 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiio APEdist_nnno C7Y Type1 255 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5DEWB 1.9 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo 59N Type1 255 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D4VB 1.84 Inactive DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaiio APEdist_nnno A1A2P Type1 252 - 543 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D4WB 2.218 Inactive DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaiio APEdist_nnno A1A2Q Type1 257 - 545 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9NBXB 2.15 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1BW5 Type1 254 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4O0TB 2.6 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 255 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 3Q4ZB 1.887 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 250 - 541 0 None S259I,K299R,D389N,L516I Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 7VTOB 2.59 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 107 Type1 255 - 542 0 TPO423 None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5DEYB 2.1 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_oooo 59T Type1 255 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5IMEB 2.217 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 6BZ Type1 250 - 541 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 9D50B 1.898 Inactive DFGinter‑None in-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1A2T Type1 253 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZJIA 1.99 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi 4OQ Type3 254 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZJIB 1.99 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi 4OQ Type3 254 - 540 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZJIC 1.99 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo 4OQ Type3 250 - 541 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZJID 1.99 Inactive DFGout‑BBAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo 4OQ Type3 253 - 541 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZJJA 2.2 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi 4OR Type3 249 - 539 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZJJB 2.2 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioi 4OR Type3 251 - 539 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZJJC 2.2 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaiii APEdist_nnno 4OR Type3 251 - 542 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZJJD 2.2 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaiii APEdist_oooo 4OR Type3 252 - 541 0 None None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZLOA 2.5 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno 4PV Type3 250 - 543 0 TPO423 None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5KBQB 2.58 Inactive None‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno No_ligand No_ligand 255 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 5KBRB 2.36 Inactive None‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno IPW Type1 255 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK1 PAK1_HUMAN 4P90B 2.49 Inactive None‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno 2K0 Type1 257 - 542 0 None D389N,T423E,E503D Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK2 PAK2_HUMAN AF-Q13177-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 241 - 507 0 None None Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN AF-Q13177-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 241 - 507 0 None None Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN 9D51A 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2Q Type1 230 - 523 0 None D368N,T402E,P498Q,M514A Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN 9LBGB 2.89 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aanoo APEdist_nnnn MLT Allosteric 91 - 522 0 None K278R Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN 9LBGA 2.89 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaioo APEdist_nnoo No_ligand No_ligand 84 - 522 0 None K278R Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN 9LBFA 2.62 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiio APEdist_nnoo No_ligand No_ligand 86 - 522 0 None D368N Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN 9LBFB 2.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 93 - 522 0 None D368N Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN 9D51B 2.1 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1A2Q Type1 231 - 522 0 None D368N,T402E,P498Q,M514A Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN 9M41A 3.02 Inactive DFGout‑BBAminus out-none out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 85 - 520 0 None K278R,D368N Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK2 PAK2_HUMAN 9M41B 3.02 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 83 - 521 0 None K278R,D368N Serine/threonine-protein kinase PAK 2 Homo sapiens
STE PAK3 PAK3_HUMAN 6FD3A 1.52 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 261 - 556 0 None A537D Serine/threonine-protein kinase PAK 3 Homo sapiens
STE PAK3 PAK3_HUMAN AF-O75914-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 275 - 542 0 None None Serine/threonine-protein kinase PAK 3 Homo sapiens
STE PAK3 PAK3_HUMAN AF-O75914-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 275 - 542 0 None None Serine/threonine-protein kinase PAK 3 Homo sapiens
STE PAK4 PAK4_HUMAN 4XBRA 2.94 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 177 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIFA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 296 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIFB 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 297 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIGA 3.01 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4JDIA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5UPKB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 588 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIEA 3.11 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 49 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIEB 3.11 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 49 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 7S46A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 None D440N,S474E Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 7S47A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 None D440N,S474E Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN AF-O96013-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 313 - 580 0 None None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN AF-O96013-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 313 - 580 0 None None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 2BVAA 2.3 Inactive DFGin‑BLAminus out-out out-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 587 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 2BVAB 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 301 - 587 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4L67A 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 2Q0NA 1.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 298 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 8YHKA 3.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 298 - 591 0 None None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 2J0IA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4XBUA 2.06 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 297 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4JDJA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474,TPO562 F461V Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4JDKA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474,TPO562 F461V Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIHA 1.97 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 298 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIIA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIJA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4JDHA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 6WLXA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 6WLYA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 7S48A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5UPLA 3.003 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 299 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5XVFA 2.655 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8FR Type1 300 - 588 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5XVAA 1.847 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8FU Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5XVGA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8FX Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5ZJWA 1.798 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 9EO Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 9D52A 2.449 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2R Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 9D53A 2.468 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1A2P Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5BMSA 2.903 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4T6 Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 2X4ZA 2.1 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii 7KC Type1 299 - 590 0 SEP474 P296G,Q297S,R298H,V299M Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4APPA 2.2 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii N53 Type1 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4NJDA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NJD Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5I0BA 3.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 67U Type1 301 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 8AHGA 1.885 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii M4I Type1 300 - 591 0 SEP474 L310A Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 8AHHA 2.037 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii M4X Type1 300 - 591 0 SEP474 L310A Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 8AHIA 2.69 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii M56 Type1 300 - 591 0 SEP474 L310A Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 2CDZA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 23D Type1 299 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5VEDA 2.301 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5VEEA 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 981 Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5VEFA 1.752 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii M77 Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 7CP3A 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii GC6 Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 7CP4A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii GCC Type1.5_Back 300 - 591 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 7CMBA 2.592 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G5X Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4O0VA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2OL Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4O0XA 2.483 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2OQ Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4O0YA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2OO Type1.5_Back 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIGB 3.01 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK5 PAK5_HUMAN AF-Q9P286-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 441 - 708 0 None None Serine/threonine-protein kinase PAK 5 Homo sapiens
STE PAK5 PAK5_HUMAN AF-Q9P286-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 441 - 708 0 None None Serine/threonine-protein kinase PAK 5 Homo sapiens
STE PAK5 PAK5_HUMAN 8C12AAA 1.549 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 426 - 717 0 SEP602 None Serine/threonine-protein kinase PAK 5 Homo sapiens
STE PAK5 PAK5_HUMAN 2F57A 1.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 425 - 715 0 SEP602 None Serine/threonine-protein kinase PAK 5 Homo sapiens
STE PAK5 PAK5_HUMAN 2F57B 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 23D Type1 425 - 718 0 SEP602 None Serine/threonine-protein kinase PAK 5 Homo sapiens
STE PAK6 PAK6_HUMAN AF-Q9NQU5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 399 - 666 0 None None Serine/threonine-protein kinase PAK 6 Homo sapiens
STE PAK6 PAK6_HUMAN AF-Q9NQU5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 399 - 666 0 None None Serine/threonine-protein kinase PAK 6 Homo sapiens
STE PAK6 PAK6_HUMAN 2C30A 1.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 385 - 674 0 SEP560 None Serine/threonine-protein kinase PAK 6 Homo sapiens
STE PAK6 PAK6_HUMAN 4KS7A 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 7KC Type1 386 - 672 0 SEP560 None Serine/threonine-protein kinase PAK 6 Homo sapiens
STE PAK6 PAK6_HUMAN 4KS8A 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 385 - 671 0 SEP560 None Serine/threonine-protein kinase PAK 6 Homo sapiens
STE SLK SLK_HUMAN AF-Q9H2G2-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 26 - 300 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN AF-Q9H2G2-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 26 - 300 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 2JFMA 2.85 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 21 - 308 0 TPO183 None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 6HVDA 1.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo GUQ Type1 19 - 309 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 2J51A 2.1 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiio APEdist_oooo DKI Type1 21 - 308 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 2JFLA 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiio APEdist_oooo DKI Type1 21 - 308 0 TPO183,SEP189 None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 2UV2A 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_oooo GVD Type1 21 - 308 0 None K25T STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 4USFA 1.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanio APEdist_nnnn 6UI Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 4USFB 1.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 6UI Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 8BEMD 2.6 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 8BEMG 2.6 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1 19 - 309 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 8BEMA 2.6 Inactive DFGout‑BBAminus out-none none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1.5_Front 19 - 309 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 8BEMB 2.6 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1.5_Front 19 - 310 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE STK10 STK10_HUMAN 4USEA 2.65 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aanio APEdist_nnnn R09 Type1 24 - 316 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4USEB 2.65 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aanio APEdist_nnnn R09 Type1 24 - 316 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN AF-O94804-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 302 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN AF-O94804-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 302 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4BC6A 2.2 Inactive DFGin‑BLAminus in-out out-none nonTYR APEdihe_aannn APEdist_nnnn XZN Type1 24 - 316 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 2J7TA 2.0 Inactive DFGin‑BLAminus in-none out-out nonTYR APEdihe_aaiii APEdist_nnoo 274 Type1 25 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 5OWRA 2.3 Inactive DFGin‑BLAminus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 1N1 Type1 23 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6HXFA 2.09 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiio APEdist_iioo R70 Type1 24 - 313 0 TPO185,SEP191,TPO208 None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6HXFB 2.09 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiio APEdist_iioo R70 Type1 24 - 314 0 TPO185,SEP191,TPO208 None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6HXFC 2.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii R70 Type1 24 - 312 0 TPO185,SEP191,TPO208 None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6HXFD 2.09 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiio APEdist_iioo R70 Type1 23 - 312 0 TPO185,SEP191,TPO208 None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 7QGPA 1.9 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaiio APEdist_iioo DJ8 Type1.5_Front 23 - 313 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 5AJQA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nooo DB8 Type1 24 - 312 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 5AJQB 2.2 Inactive DFGin‑None out-none out-none nonTYR APEdihe_aanii APEdist_nnnn DB8 Type1 25 - 312 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6GTTA 2.25 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aanio APEdist_nnnn B96 Type2 18 - 316 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6EIMA 1.43 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo B6E Type2 26 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6EIMB 1.43 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo B6E Type2 23 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4AOTA 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nnno GW8 Type1 18 - 314 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4AOTB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nnoo GW8 Type1 18 - 314 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4USDA 3.05 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno R09 Type1 24 - 314 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4USDB 3.05 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno R09 Type1 24 - 314 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4EQUA 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo G6I Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4EQUB 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nooo G6I Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6I2YA 2.56 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6I2YB 2.56 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 5OWQA 2.7 Inactive None‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn 38O Type1 30 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 5OWQB 2.7 Inactive None‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 38O Type1 32 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK24 STK24_HUMAN 3A7HA 1.96 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3A7HB 1.96 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 17 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3A7JA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMLA 1.882 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 30 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN AF-Q9Y6E0-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 294 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN AF-Q9Y6E0-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 294 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3A7FA 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3A7GA 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3A7GB 2.0 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4U8ZA 1.63 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3FE Type1 24 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4W8DA 1.77 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3JA Type1 24 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4W8EA 1.79 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3JB Type1 24 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3A7IA 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3CKXA 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 32 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMMA 1.852 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 35R Type1 18 - 309 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMNA 2.091 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DB8 Type1 27 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMOA 1.898 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 34L Type1 18 - 309 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMPA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DKI Type1 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMQA 1.769 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 34U Type1 18 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMSA 1.883 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 1N1 Type1 27 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMTA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H1N Type1 27 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMUA 1.546 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SKE Type1 24 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMVA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 34W Type1 19 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMXA 1.882 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii H8H Type1 24 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMYA 1.883 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMZA 1.88 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B49 Type1 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QNAA 1.849 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X11 Type1 27 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QO9A 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 627 Type1 30 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QO9B 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 627 Type1 25 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMWA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KS1 Type1.5_Back 24 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3ZHPC 2.9 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 31 - 300 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3ZHPD 2.9 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaiii APEdist_nooo No_ligand No_ligand 32 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8BZIA 1.72 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SJL Type1.5_Back 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8BZJA 2.52 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SJX Type1.5_Back 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B30A 2.1 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 59T Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B31A 1.8 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQ8 Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B32A 1.75 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQQ Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B33A 1.9 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQE Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B34A 2.1 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQK Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B35A 2.4 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQB Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B35B 2.4 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQB Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8BZJB 2.52 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn SJX Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLRA 1.85 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYN Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLRB 1.85 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYN Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLSA 1.61 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYH Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLTA 1.47 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VZ2 Type1.5_Front 25 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLQA 1.64 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo VY0 Type1 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4O27B 3.185 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 30 - 309 0 None T190E Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 3CKWA 1.96 Inactive None‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni No_ligand No_ligand 32 - 310 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK25 STK25_HUMAN AF-O00506-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 278 0 None None Serine/threonine-protein kinase 25 Homo sapiens
STE STK25 STK25_HUMAN AF-O00506-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 278 0 None None Serine/threonine-protein kinase 25 Homo sapiens
STE STK25 STK25_HUMAN 2XIKA 1.97 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii J60 Type1 3 - 292 0 TPO174 None Serine/threonine-protein kinase 25 Homo sapiens
STE STK25 STK25_HUMAN 7Z4VA 1.644 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii IB5 Type1 3 - 293 0 TPO174 None Serine/threonine-protein kinase 25 Homo sapiens
STE STK25 STK25_HUMAN 4NZWB 3.583 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnni J60 Type1 11 - 292 0 None D158A Serine/threonine-protein kinase 25 Homo sapiens
STE STK26 STK26_HUMAN AF-Q9P289-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 282 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN AF-Q9P289-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 282 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 7B36C 2.107 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo 59T Type1.5_Back 17 - 299 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 7B36A 2.107 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 59T Type1.5_Front 18 - 300 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 3GGFA 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo GVD Type1 17 - 300 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 3GGFB 2.35 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo GVD Type1 18 - 297 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 4FZFB 3.64 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo DKI Type1 18 - 297 0 None D162A Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 4FZAB 3.15 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 18 - 297 0 None D162A Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 4FZDB 3.25 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 18 - 297 0 None D162A Serine/threonine-protein kinase 26 Homo sapiens
STE STK3 STK3_HUMAN 5DH3B 2.468 Inactive DFGin‑ABAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 18 - 302 0 TPO174,TPO180 None Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN AF-Q13188-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 286 0 None None Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN AF-Q13188-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 286 0 None None Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 8A66A 1.901 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5BS Type1 24 - 303 0 TPO180 None Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 8A66B 1.901 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5BS Type1 18 - 304 0 TPO174,TPO180,TPO268 None Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 5DH3A 2.468 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 19 - 307 0 TPO174,TPO180 None Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 6AO5A 2.955 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioo APEdist_nooo ANP ATPlike 28 - 488 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LGDA 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 16 - 488 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LGDB 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 10 - 488 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LGDC 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 12 - 490 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LGDD 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 11 - 489 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LG4A 2.42 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 18 - 308 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LG4B 2.42 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 18 - 308 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LG4C 2.42 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 18 - 307 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LG4E 2.42 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 18 - 308 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LG4F 2.42 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 18 - 310 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LG4D 2.42 Inactive None‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 26 - 308 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK39 STK39_HUMAN AF-Q9UEW8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 55 - 345 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Homo sapiens
STE STK39 STK39_HUMAN AF-Q9UEW8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 55 - 345 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Homo sapiens
STE STK4 STK4_HUMAN 6YATA 2.58 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3FX, OJ5 Allosteric, Type1 18 - 308 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN AF-Q13043-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 289 0 None None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN AF-Q13043-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 289 0 None None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 3COMA 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 3COMB 2.2 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 300 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 8A5JA 2.123 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 28 - 309 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 8PAVA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XOZ Type1 23 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 8PAVB 1.9 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii XOZ Type1 14 - 299 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 8PAWA 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XQL Type1 23 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 8PAWB 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XQL Type1 14 - 299 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 6YATB 2.58 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii OJ5 Type1 29 - 307 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 9IICA 2.78 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 11 - 308 0 None K59R Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 9IICB 2.78 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 11 - 311 0 None K59R Serine/threonine-protein kinase 4 Homo sapiens
STE STK4 STK4_HUMAN 8A5JB 2.123 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 32 - 309 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STE STRADA STRAA_HUMAN 2WTKB 2.65 Pseudo DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ANP ATPlike 61 - 431 0 None None STE20-related kinase adapter protein alpha Homo sapiens
STE STRADA STRAA_HUMAN 2WTKE 2.65 Pseudo DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaoai APEdist_iooo ANP ATPlike 60 - 431 0 None None STE20-related kinase adapter protein alpha Homo sapiens
STE STRADA STRAA_HUMAN 3GNIB 2.35 Pseudo DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaoai APEdist_iooo ATP ATPlike 60 - 431 0 None None STE20-related kinase adapter protein alpha Homo sapiens
STE STRADA STRAA_HUMAN 8VSUB 2.86 Pseudo DFGin‑None out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ADP ATPlike 60 - 401 0 None None STE20-related kinase adapter protein alpha Homo sapiens
STE TAOK1 TAOK1_HUMAN AF-Q7L7X3-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 20 - 289 0 None None Serine/threonine-protein kinase TAO1 Homo sapiens
STE TAOK1 TAOK1_HUMAN AF-Q7L7X3-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 20 - 289 0 None None Serine/threonine-protein kinase TAO1 Homo sapiens
STE TAOK2 TAOK2_HUMAN AF-Q9UL54-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 20 - 289 0 None None Serine/threonine-protein kinase TAO2 Homo sapiens
STE TAOK2 TAOK2_HUMAN AF-Q9UL54-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 20 - 289 0 None None Serine/threonine-protein kinase TAO2 Homo sapiens
STE TAOK3 TAOK3_HUMAN 6BDNA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 8 - 314 0 None R2A,K3A Serine/threonine-protein kinase TAO3 Homo sapiens
STE TAOK3 TAOK3_HUMAN AF-Q9H2K8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 285 0 None None Serine/threonine-protein kinase TAO3 Homo sapiens
STE TAOK3 TAOK3_HUMAN AF-Q9H2K8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 285 0 None None Serine/threonine-protein kinase TAO3 Homo sapiens
STE TNIK TNIK_HUMAN 7XZRB 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 12 - 312 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN AF-Q9UKE5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN AF-Q9UKE5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 6RA5B 2.9 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 14 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 7XZQA 2.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 11 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 8ZMLB 2.489 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1D8H Type1 10 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 6RA5A 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JWE Type1 12 - 309 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 6RA7A 1.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii JWK Type1 13 - 314 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 8WM0A 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5AX9A 2.4 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 4KT Type1 12 - 307 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5AX9B 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 4KT Type1 13 - 307 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5AX9C 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoii APEdist_nnno 4KT Type1 12 - 309 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 2X7FA 2.8 Inactive DFGin‑BLAminus in-none out-out nonTYR APEdihe_aaini APEdist_nnno 824 Type1 15 - 313 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 2X7FB 2.8 Inactive DFGin‑BLAminus in-none out-out nonTYR APEdihe_aaioi APEdist_nnno 824 Type1 13 - 313 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 2X7FC 2.8 Inactive DFGin‑BLAminus in-none out-none nonTYR APEdihe_aanni APEdist_nnnn 824 Type1 14 - 313 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 2X7FD 2.8 None DFGin‑BLAminus in-none none-none nonTYR APEdihe_aanni APEdist_nnnn 824 Type1 17 - 306 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 8ZMLA 2.489 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1D8H Type1.5_Back 11 - 312 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 7XZRA 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP Type1.5_Front 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5CWZA 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oioo No_ligand No_ligand 11 - 307 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5CWZB 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 11 - 307 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5CWZC 2.9 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 15 - 308 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5D7AA 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oioo 58C Type1 11 - 310 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5D7AB 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oioo 58C Type1 11 - 307 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 5D7AC 2.9 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 58C Type1 13 - 310 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 2X7FE 2.8 Inactive DFGin‑None in-none none-none nonTYR APEdihe_aanni APEdist_nnnn 824 Type1 14 - 309 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 8X88A 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo No_ligand No_ligand 15 - 311 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 8X88B 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE MAP3K14 M3K14_MOUSE 4G3CA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi No_ligand No_ligand 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3CB 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii No_ligand No_ligand 334 - 674 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3GA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 0WA Type1 345 - 675 0 None V408L Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3FA 1.642 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 0WB Type1 345 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8PA 2.32 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 774 Type1 333 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8PB 2.32 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 774 Type1 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8QA 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 76Y Type1 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8QB 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 76Y Type1 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6MYNA 2.744 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi K6Y Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6MYNB 2.744 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi K6Y Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8OA 2.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 76Z Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8OB 2.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 76Z Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6G4YA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ELZ Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6G4YB 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ELZ Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6G4ZA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ELW Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6G4ZB 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ELW Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3EA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 0WC Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3EB 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 0WC Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 7SZRA 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii DYQ Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 7SZRB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi DYQ Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE STK39 STK39_MOUSE 5D9HA 3.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo ATP ATPlike 65 - 363 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5D9HB 3.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ATP ATPlike 65 - 364 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXA 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 365 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXB 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 364 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE MAP2K1 MP2K1_RABIT 7JUQC 3.22 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP ATPlike 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUWC 2.88 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 2Y4IC 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP ATPlike 37 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JURC 2.82 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type1 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUTC 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 41 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUUC 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 43 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUVC 3.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUXC 3.34 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUYC 3.096 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUZC 3.21 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV0C 3.63 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV1C 3.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 5KKRC 3.509 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUSC 2.99 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo VKD, ANP Type3, ATPlike 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE TAOK2 TAOK2_RAT 1U5RA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5RB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5QA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5QB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 2GCDA 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 2GCDB 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus

STE / All / All

Total number of chains: 53
Active chains: 6
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 26 49.1% 1U5RA
DFGin BLBplus 15 28.3% 8BW9C
DFGin ABAminus 5 9.4% 7XBRC
DFGin None 5 9.4% 7XBRB
DFGin BLBtrans 2 3.8% 5D9HB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MKK5 M2K5_ARATH 7XBRA 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 63 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRC 3.2 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 64 - 329 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRD 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 68 - 329 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRF 3.2 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 64 - 327 0 SEP66,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRH 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 65 - 329 0 SEP66,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRB 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 65 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRE 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 65 - 328 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE MKK5 M2K5_ARATH 7XBRG 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 64 - 327 0 SEP66,TPO83,TPO108,TPO215,SEP221 None Mitogen-activated protein kinase kinase 5 Arabidopsis thaliana
STE DSOR1 DSOR1_DROME 8BW9C 3.32 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 81 - 384 0 None None Dual specificity mitogen-activated protein kinase kinase dSOR1 Drosophila melanogaster
STE MAP3K14 M3K14_MOUSE 4G3CA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi No_ligand No_ligand 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3CB 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii No_ligand No_ligand 334 - 674 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3GA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 0WA Type1 345 - 675 0 None V408L Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3FA 1.642 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 0WB Type1 345 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8PA 2.32 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 774 Type1 333 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8PB 2.32 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 774 Type1 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8QA 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 76Y Type1 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8QB 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 76Y Type1 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6MYNA 2.744 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi K6Y Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6MYNB 2.744 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi K6Y Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8OA 2.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 76Z Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 5T8OB 2.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 76Z Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6G4YA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ELZ Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6G4YB 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ELZ Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6G4ZA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ELW Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 6G4ZB 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ELW Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3EA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 0WC Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 4G3EB 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii 0WC Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 7SZRA 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii DYQ Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE MAP3K14 M3K14_MOUSE 7SZRB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi DYQ Type1.5_Back 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Mus musculus
STE STK39 STK39_MOUSE 5D9HA 3.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo ATP ATPlike 65 - 363 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5D9HB 3.1 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ATP ATPlike 65 - 364 0 None None STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXA 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 365 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXB 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 364 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE MAP2K1 MP2K1_RABIT 7JUQC 3.22 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP ATPlike 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUWC 2.88 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 2Y4IC 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP ATPlike 37 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JURC 2.82 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type1 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUTC 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 41 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUUC 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 43 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUVC 3.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUXC 3.34 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUYC 3.096 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUZC 3.21 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV0C 3.63 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV1C 3.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 5KKRC 3.509 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUSC 2.99 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo VKD, ANP Type3, ATPlike 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE TAOK2 TAOK2_RAT 1U5RA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5RB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5QA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 1U5QB 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 2GCDA 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 2GCDB 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus