MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

Group: TKL
Uniprot: M3K7_HUMAN
Domain boundary: 36 - 286


Total number of chains: 28
Spatial Dihedral Chains Representative
DFGin BLAminus 7 AF-O43318-K1A
DFGin BLBminus 4 2EVAA
DFGin BLBplus 2 4L53A
DFGin None 3 8GW3A
DFGinter None 3 8GW3B
DFGout BBAminus 4 5GJDA
DFGout None 3 5GJFA
None None 2 5J8IA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-O43318-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 28 - 294 None None 0
5V5NA 2.006 None DFGin BLAminus in-in none-out EDH Type1 31 - 496 None None 12
7NTHA 1.97 None DFGin BLAminus in-in none-out URW Type1 31 - 496 None None 12
7NTIA 1.98 None DFGin BLAminus in-in none-out UWZ Type1 31 - 496 None None 11
5JGAA 2.0 None DFGin BLAminus in-in none-out 6KC Type1 31 - 496 None None 11
5JGDA 3.101 None DFGin BLAminus in-in none-out 6KD Type1 31 - 495 None None 11
9FPDA 2.402 Active DFGin BLAminus in-in in-in A1IED Type1 31 - 496 None X187,X192 3
2EVAA 2.0 Inactive DFGin BLBminus in-in none-out ADN Type1 31 - 305 None None 12
4GS6A 2.2 Inactive DFGin BLBminus in-in none-out 1FM Type1 31 - 496 None None 13
4L3PA 2.68 Inactive DFGin BLBminus in-in none-in 1UH Type1 31 - 497 None None 13
5JGBA 2.8 Inactive DFGin BLBminus in-none none-out 6JV Type1 31 - 496 None None 12
4L52A 2.54 Inactive DFGin BLBplus in-in none-out 1UL Type1 31 - 496 None None 12
4L53A 2.55 Inactive DFGin BLBplus in-in none-out 1UO Type1 31 - 496 None None 11
8GW3A 2.05 Inactive DFGin None out-out out-out No_ligand No_ligand 27 - 497 None None 0
5JH6A 2.365 Inactive DFGin None out-out none-out T92 Type1 31 - 496 None None 14
5GJGA 2.61 Inactive DFGin None out-out none-out 6V5 Type1 31 - 496 None None 14
8GW3B 2.05 Inactive DFGinter None out-out out-out No_ligand No_ligand 27 - 497 None None 0
8GW3C 2.05 Inactive DFGinter None out-none none-out No_ligand No_ligand 25 - 497 None None 3
8GW3D 2.05 Inactive DFGinter None out-out none-out No_ligand No_ligand 27 - 495 None None 3
5E7RA 2.11 Inactive DFGout BBAminus none-none none-out 5KW Type1 31 - 496 None None 13
2YIYA 2.49 Inactive DFGout BBAminus in-in none-out YIY Type2 31 - 496 None None 13
4O91A 2.393 Inactive DFGout BBAminus in-in none-out NG2 Type2 31 - 496 None None 13
5GJDA 2.79 Inactive DFGout BBAminus in-in out-out 6V3 Type2 31 - 495 None None 10
5J9LA 2.752 Inactive DFGout None in-out none-out 6HF Type1 31 - 496 None None 14
5J7SA 2.368 Inactive DFGout None out-out none-out 6H3 Type1 31 - 496 None None 14
5GJFA 2.89 Inactive DFGout None in-in out-out 6V4 Type2 31 - 496 None None 0
5J8IA 2.404 Inactive None None in-in none-out 6H4 Type1 31 - 496 None None 15
5JK3A 2.371 Inactive None None in-out none-out 6L4 Type1 31 - 496 None None 15

MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

Group: TKL
Total number of chains: 28
Spatial Dihedral Chains Representative
DFGin BLAminus 7 AF-O43318-K1A
DFGin BLBminus 4 2EVAA
DFGin BLBplus 2 4L53A
DFGin None 3 8GW3A
DFGinter None 3 8GW3B
DFGout BBAminus 4 5GJDA
DFGout None 3 5GJFA
None None 2 5J8IA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens M3K7_HUMAN AF-O43318-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 28 - 294 None None 0
Homo sapiens M3K7_HUMAN 5V5NA 2.006 None DFGin BLAminus in-in none-out EDH Type1 31 - 496 None None 12
Homo sapiens M3K7_HUMAN 7NTHA 1.97 None DFGin BLAminus in-in none-out URW Type1 31 - 496 None None 12
Homo sapiens M3K7_HUMAN 7NTIA 1.98 None DFGin BLAminus in-in none-out UWZ Type1 31 - 496 None None 11
Homo sapiens M3K7_HUMAN 5JGAA 2.0 None DFGin BLAminus in-in none-out 6KC Type1 31 - 496 None None 11
Homo sapiens M3K7_HUMAN 5JGDA 3.101 None DFGin BLAminus in-in none-out 6KD Type1 31 - 495 None None 11
Homo sapiens M3K7_HUMAN 9FPDA 2.402 Active DFGin BLAminus in-in in-in A1IED Type1 31 - 496 None X187,X192 3
Homo sapiens M3K7_HUMAN 2EVAA 2.0 Inactive DFGin BLBminus in-in none-out ADN Type1 31 - 305 None None 12
Homo sapiens M3K7_HUMAN 4GS6A 2.2 Inactive DFGin BLBminus in-in none-out 1FM Type1 31 - 496 None None 13
Homo sapiens M3K7_HUMAN 4L3PA 2.68 Inactive DFGin BLBminus in-in none-in 1UH Type1 31 - 497 None None 13
Homo sapiens M3K7_HUMAN 5JGBA 2.8 Inactive DFGin BLBminus in-none none-out 6JV Type1 31 - 496 None None 12
Homo sapiens M3K7_HUMAN 4L52A 2.54 Inactive DFGin BLBplus in-in none-out 1UL Type1 31 - 496 None None 12
Homo sapiens M3K7_HUMAN 4L53A 2.55 Inactive DFGin BLBplus in-in none-out 1UO Type1 31 - 496 None None 11
Homo sapiens M3K7_HUMAN 8GW3A 2.05 Inactive DFGin None out-out out-out No_ligand No_ligand 27 - 497 None None 0
Homo sapiens M3K7_HUMAN 5JH6A 2.365 Inactive DFGin None out-out none-out T92 Type1 31 - 496 None None 14
Homo sapiens M3K7_HUMAN 5GJGA 2.61 Inactive DFGin None out-out none-out 6V5 Type1 31 - 496 None None 14
Homo sapiens M3K7_HUMAN 8GW3B 2.05 Inactive DFGinter None out-out out-out No_ligand No_ligand 27 - 497 None None 0
Homo sapiens M3K7_HUMAN 8GW3C 2.05 Inactive DFGinter None out-none none-out No_ligand No_ligand 25 - 497 None None 3
Homo sapiens M3K7_HUMAN 8GW3D 2.05 Inactive DFGinter None out-out none-out No_ligand No_ligand 27 - 495 None None 3
Homo sapiens M3K7_HUMAN 5E7RA 2.11 Inactive DFGout BBAminus none-none none-out 5KW Type1 31 - 496 None None 13
Homo sapiens M3K7_HUMAN 2YIYA 2.49 Inactive DFGout BBAminus in-in none-out YIY Type2 31 - 496 None None 13
Homo sapiens M3K7_HUMAN 4O91A 2.393 Inactive DFGout BBAminus in-in none-out NG2 Type2 31 - 496 None None 13
Homo sapiens M3K7_HUMAN 5GJDA 2.79 Inactive DFGout BBAminus in-in out-out 6V3 Type2 31 - 495 None None 10
Homo sapiens M3K7_HUMAN 5J9LA 2.752 Inactive DFGout None in-out none-out 6HF Type1 31 - 496 None None 14
Homo sapiens M3K7_HUMAN 5J7SA 2.368 Inactive DFGout None out-out none-out 6H3 Type1 31 - 496 None None 14
Homo sapiens M3K7_HUMAN 5GJFA 2.89 Inactive DFGout None in-in out-out 6V4 Type2 31 - 496 None None 0
Homo sapiens M3K7_HUMAN 5J8IA 2.404 Inactive None None in-in none-out 6H4 Type1 31 - 496 None None 15
Homo sapiens M3K7_HUMAN 5JK3A 2.371 Inactive None None in-out none-out 6L4 Type1 31 - 496 None None 15

MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

No non-human structures known.