MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

Group: STE
Uniprot: M3K5_HUMAN
Domain boundary: 673 - 938


Total number of chains: 59
Spatial Dihedral Chains Representative
DFGin BLAminus 54 AF-Q99683-K1A
DFGin None 2 5VILC
DFGinter BABtrans 2 2CLQA
DFGout None 1 8QGYA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q99683-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 665 - 946 None None 0
4BICB 2.62 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 670 - 941 T838E None 9
8QGYB 3.71 Active DFGin BLAminus in-in in-in No_ligand No_ligand 95 - 940 None None 0
6OYTA 2.824 None DFGin BLAminus in-in in-none NJV Type1 667 - 939 None None 20
6OYTB 2.824 Inactive DFGin BLAminus in-in in-out NJV Type1 670 - 939 None None 10
6OYTC 2.824 None DFGin BLAminus in-in in-none NJV Type1 671 - 938 None None 13
6OYTD 2.824 Active DFGin BLAminus in-in in-in NJV Type1 667 - 939 None None 10
5UOXA 2.5 Active DFGin BLAminus in-in in-in 8GY Type1 670 - 940 None None 8
5UOXB 2.5 Active DFGin BLAminus in-in in-in 8GY Type1 670 - 939 None None 8
5UP3A 2.95 Active DFGin BLAminus in-in in-in 8GS Type1 670 - 940 None None 8
5UP3B 2.95 Active DFGin BLAminus in-in in-in 8GS Type1 671 - 939 None None 11
5V19A 3.1 Active DFGin BLAminus in-in in-in 8V4 Type1 671 - 939 None None 8
5V19B 3.1 Active DFGin BLAminus in-in in-in 8V4 Type1 670 - 940 None None 6
5V24A 2.5 Active DFGin BLAminus in-in in-in 8V7 Type1 671 - 939 None None 9
5V24B 2.5 Active DFGin BLAminus in-in in-in 8V7 Type1 670 - 940 None None 8
3VW6A 2.4 Active DFGin BLAminus in-in in-in IM6 Type1 671 - 939 None None 8
3VW6B 2.4 Active DFGin BLAminus in-in in-in IM6 Type1 671 - 939 None None 10
5UORA 2.75 Active DFGin BLAminus in-in in-in 8GV Type1 671 - 939 None None 9
5UORB 2.75 Active DFGin BLAminus in-in in-in 8GV Type1 670 - 939 None None 8
5VILA 2.64 Active DFGin BLAminus in-in in-in 9E1 Type1 670 - 940 None None 0
5VILB 2.64 Active DFGin BLAminus in-in in-in 9E1 Type1 670 - 940 None None 0
5VILD 2.64 Active DFGin BLAminus in-in in-in 9E1 Type1 670 - 940 None None 0
5VIOA 2.84 Active DFGin BLAminus in-in in-in 9E4 Type1 670 - 940 None None 0
5VIOB 2.84 Active DFGin BLAminus in-in in-in 9E4 Type1 670 - 940 None None 0
5VIOD 2.84 Active DFGin BLAminus in-in in-in 9E4 Type1 670 - 940 None None 0
6XIHA 2.65 Active DFGin BLAminus in-in in-in V3S Type1 671 - 940 None None 8
6XIHB 2.65 Active DFGin BLAminus in-in in-in V3S Type1 671 - 939 None None 12
6E2MA 2.253 Active DFGin BLAminus in-in in-in KK7 Type1 670 - 939 None X838 3
6E2MB 2.253 Active DFGin BLAminus in-in in-in KK7 Type1 671 - 940 None X838 10
6E2NA 2.098 Active DFGin BLAminus in-in in-in KK8 Type1 670 - 939 None X838 3
6E2NB 2.098 Active DFGin BLAminus in-in in-in KK8 Type1 670 - 939 None X838 10
6E2OA 2.389 Active DFGin BLAminus in-in in-in S0L Type1 670 - 939 None X838 4
6E2OB 2.389 Active DFGin BLAminus in-in in-in S0L Type1 671 - 939 None X838 10
6VREA 2.29 Active DFGin BLAminus in-in in-in RFG Type1 671 - 940 None None 7
6VREB 2.29 Active DFGin BLAminus in-in in-in RFG Type1 669 - 940 None None 8
6OYWA 2.603 Active DFGin BLAminus in-in in-in NKJ Type1 671 - 939 T838E None 5
6OYWB 2.603 Active DFGin BLAminus in-in in-in NKJ Type1 671 - 940 T838E None 10
6OYWC 2.603 Active DFGin BLAminus in-in in-in NKJ Type1 671 - 939 T838E None 5
6OYWD 2.603 Active DFGin BLAminus in-in in-in NKJ Type1 671 - 939 T838E None 7
4BIBA 2.43 Inactive DFGin BLAminus out-out in-in IEO Type1 670 - 939 T838E None 8
4BIBB 2.43 Inactive DFGin BLAminus in-out in-in IEO Type1 670 - 940 T838E None 9
4BICA 2.62 Inactive DFGin BLAminus out-out in-in IE4 Type1 670 - 940 T838E None 6
4BIDA 2.8 Inactive DFGin BLAminus in-out in-in IE8 Type1 670 - 939 T838E None 8
4BIDB 2.8 Active DFGin BLAminus in-in in-in IE8 Type1 670 - 940 T838E None 9
4BIEA 2.36 Active DFGin BLAminus in-in in-in IE6 Type1 670 - 940 T838E None 6
4BIEB 2.36 Active DFGin BLAminus in-in in-in IE6 Type1 670 - 941 T838E None 8
4BF2A 2.11 None DFGin BLAminus out-none in-in STU Type1 671 - 939 T838E None 6
4BF2B 2.11 None DFGin BLAminus in-none in-in STU Type1 671 - 940 T838E None 9
4BHNA 2.3 Active DFGin BLAminus in-in in-in BH9 Type1 670 - 940 T838E None 8
4BHNB 2.3 Active DFGin BLAminus in-in in-in BH9 Type1 670 - 938 T838E None 8
7MU6A 2.165 Active DFGin BLAminus in-in in-in A1AWT Type1 671 - 939 None None 7
7MU6B 2.165 Active DFGin BLAminus in-in in-in A1AWT Type1 671 - 940 None None 9
7MU7A 2.298 Active DFGin BLAminus in-in in-in RFG Type1 671 - 940 None None 7
7MU7B 2.298 Active DFGin BLAminus in-in in-in RFG Type1 669 - 940 None None 8
5VIOC 2.84 Inactive DFGin None in-in in-in No_ligand No_ligand 670 - 940 None None 0
5VILC 2.64 Inactive DFGin None in-in in-in 9E1 Type1 670 - 940 None None 0
2CLQA 2.3 Inactive DFGinter BABtrans out-out in-in STU Type1 670 - 940 None None 5
2CLQB 2.3 Inactive DFGinter BABtrans in-none in-in STU Type1 670 - 940 None None 8
8QGYA 3.71 Inactive DFGout None in-out in-none No_ligand No_ligand 95 - 940 None None 13

MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

Group: STE
Total number of chains: 59
Spatial Dihedral Chains Representative
DFGin BLAminus 54 AF-Q99683-K1A
DFGin None 2 5VILC
DFGinter BABtrans 2 2CLQA
DFGout None 1 8QGYA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens M3K5_HUMAN AF-Q99683-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 665 - 946 None None 0
Homo sapiens M3K5_HUMAN 4BICB 2.62 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 670 - 941 T838E None 9
Homo sapiens M3K5_HUMAN 8QGYB 3.71 Active DFGin BLAminus in-in in-in No_ligand No_ligand 95 - 940 None None 0
Homo sapiens M3K5_HUMAN 6OYTA 2.824 None DFGin BLAminus in-in in-none NJV Type1 667 - 939 None None 20
Homo sapiens M3K5_HUMAN 6OYTB 2.824 Inactive DFGin BLAminus in-in in-out NJV Type1 670 - 939 None None 10
Homo sapiens M3K5_HUMAN 6OYTC 2.824 None DFGin BLAminus in-in in-none NJV Type1 671 - 938 None None 13
Homo sapiens M3K5_HUMAN 6OYTD 2.824 Active DFGin BLAminus in-in in-in NJV Type1 667 - 939 None None 10
Homo sapiens M3K5_HUMAN 5UOXA 2.5 Active DFGin BLAminus in-in in-in 8GY Type1 670 - 940 None None 8
Homo sapiens M3K5_HUMAN 5UOXB 2.5 Active DFGin BLAminus in-in in-in 8GY Type1 670 - 939 None None 8
Homo sapiens M3K5_HUMAN 5UP3A 2.95 Active DFGin BLAminus in-in in-in 8GS Type1 670 - 940 None None 8
Homo sapiens M3K5_HUMAN 5UP3B 2.95 Active DFGin BLAminus in-in in-in 8GS Type1 671 - 939 None None 11
Homo sapiens M3K5_HUMAN 5V19A 3.1 Active DFGin BLAminus in-in in-in 8V4 Type1 671 - 939 None None 8
Homo sapiens M3K5_HUMAN 5V19B 3.1 Active DFGin BLAminus in-in in-in 8V4 Type1 670 - 940 None None 6
Homo sapiens M3K5_HUMAN 5V24A 2.5 Active DFGin BLAminus in-in in-in 8V7 Type1 671 - 939 None None 9
Homo sapiens M3K5_HUMAN 5V24B 2.5 Active DFGin BLAminus in-in in-in 8V7 Type1 670 - 940 None None 8
Homo sapiens M3K5_HUMAN 3VW6A 2.4 Active DFGin BLAminus in-in in-in IM6 Type1 671 - 939 None None 8
Homo sapiens M3K5_HUMAN 3VW6B 2.4 Active DFGin BLAminus in-in in-in IM6 Type1 671 - 939 None None 10
Homo sapiens M3K5_HUMAN 5UORA 2.75 Active DFGin BLAminus in-in in-in 8GV Type1 671 - 939 None None 9
Homo sapiens M3K5_HUMAN 5UORB 2.75 Active DFGin BLAminus in-in in-in 8GV Type1 670 - 939 None None 8
Homo sapiens M3K5_HUMAN 5VILA 2.64 Active DFGin BLAminus in-in in-in 9E1 Type1 670 - 940 None None 0
Homo sapiens M3K5_HUMAN 5VILB 2.64 Active DFGin BLAminus in-in in-in 9E1 Type1 670 - 940 None None 0
Homo sapiens M3K5_HUMAN 5VILD 2.64 Active DFGin BLAminus in-in in-in 9E1 Type1 670 - 940 None None 0
Homo sapiens M3K5_HUMAN 5VIOA 2.84 Active DFGin BLAminus in-in in-in 9E4 Type1 670 - 940 None None 0
Homo sapiens M3K5_HUMAN 5VIOB 2.84 Active DFGin BLAminus in-in in-in 9E4 Type1 670 - 940 None None 0
Homo sapiens M3K5_HUMAN 5VIOD 2.84 Active DFGin BLAminus in-in in-in 9E4 Type1 670 - 940 None None 0
Homo sapiens M3K5_HUMAN 6XIHA 2.65 Active DFGin BLAminus in-in in-in V3S Type1 671 - 940 None None 8
Homo sapiens M3K5_HUMAN 6XIHB 2.65 Active DFGin BLAminus in-in in-in V3S Type1 671 - 939 None None 12
Homo sapiens M3K5_HUMAN 6E2MA 2.253 Active DFGin BLAminus in-in in-in KK7 Type1 670 - 939 None X838 3
Homo sapiens M3K5_HUMAN 6E2MB 2.253 Active DFGin BLAminus in-in in-in KK7 Type1 671 - 940 None X838 10
Homo sapiens M3K5_HUMAN 6E2NA 2.098 Active DFGin BLAminus in-in in-in KK8 Type1 670 - 939 None X838 3
Homo sapiens M3K5_HUMAN 6E2NB 2.098 Active DFGin BLAminus in-in in-in KK8 Type1 670 - 939 None X838 10
Homo sapiens M3K5_HUMAN 6E2OA 2.389 Active DFGin BLAminus in-in in-in S0L Type1 670 - 939 None X838 4
Homo sapiens M3K5_HUMAN 6E2OB 2.389 Active DFGin BLAminus in-in in-in S0L Type1 671 - 939 None X838 10
Homo sapiens M3K5_HUMAN 6VREA 2.29 Active DFGin BLAminus in-in in-in RFG Type1 671 - 940 None None 7
Homo sapiens M3K5_HUMAN 6VREB 2.29 Active DFGin BLAminus in-in in-in RFG Type1 669 - 940 None None 8
Homo sapiens M3K5_HUMAN 6OYWA 2.603 Active DFGin BLAminus in-in in-in NKJ Type1 671 - 939 T838E None 5
Homo sapiens M3K5_HUMAN 6OYWB 2.603 Active DFGin BLAminus in-in in-in NKJ Type1 671 - 940 T838E None 10
Homo sapiens M3K5_HUMAN 6OYWC 2.603 Active DFGin BLAminus in-in in-in NKJ Type1 671 - 939 T838E None 5
Homo sapiens M3K5_HUMAN 6OYWD 2.603 Active DFGin BLAminus in-in in-in NKJ Type1 671 - 939 T838E None 7
Homo sapiens M3K5_HUMAN 4BIBA 2.43 Inactive DFGin BLAminus out-out in-in IEO Type1 670 - 939 T838E None 8
Homo sapiens M3K5_HUMAN 4BIBB 2.43 Inactive DFGin BLAminus in-out in-in IEO Type1 670 - 940 T838E None 9
Homo sapiens M3K5_HUMAN 4BICA 2.62 Inactive DFGin BLAminus out-out in-in IE4 Type1 670 - 940 T838E None 6
Homo sapiens M3K5_HUMAN 4BIDA 2.8 Inactive DFGin BLAminus in-out in-in IE8 Type1 670 - 939 T838E None 8
Homo sapiens M3K5_HUMAN 4BIDB 2.8 Active DFGin BLAminus in-in in-in IE8 Type1 670 - 940 T838E None 9
Homo sapiens M3K5_HUMAN 4BIEA 2.36 Active DFGin BLAminus in-in in-in IE6 Type1 670 - 940 T838E None 6
Homo sapiens M3K5_HUMAN 4BIEB 2.36 Active DFGin BLAminus in-in in-in IE6 Type1 670 - 941 T838E None 8
Homo sapiens M3K5_HUMAN 4BF2A 2.11 None DFGin BLAminus out-none in-in STU Type1 671 - 939 T838E None 6
Homo sapiens M3K5_HUMAN 4BF2B 2.11 None DFGin BLAminus in-none in-in STU Type1 671 - 940 T838E None 9
Homo sapiens M3K5_HUMAN 4BHNA 2.3 Active DFGin BLAminus in-in in-in BH9 Type1 670 - 940 T838E None 8
Homo sapiens M3K5_HUMAN 4BHNB 2.3 Active DFGin BLAminus in-in in-in BH9 Type1 670 - 938 T838E None 8
Homo sapiens M3K5_HUMAN 7MU6A 2.165 Active DFGin BLAminus in-in in-in A1AWT Type1 671 - 939 None None 7
Homo sapiens M3K5_HUMAN 7MU6B 2.165 Active DFGin BLAminus in-in in-in A1AWT Type1 671 - 940 None None 9
Homo sapiens M3K5_HUMAN 7MU7A 2.298 Active DFGin BLAminus in-in in-in RFG Type1 671 - 940 None None 7
Homo sapiens M3K5_HUMAN 7MU7B 2.298 Active DFGin BLAminus in-in in-in RFG Type1 669 - 940 None None 8
Homo sapiens M3K5_HUMAN 5VIOC 2.84 Inactive DFGin None in-in in-in No_ligand No_ligand 670 - 940 None None 0
Homo sapiens M3K5_HUMAN 5VILC 2.64 Inactive DFGin None in-in in-in 9E1 Type1 670 - 940 None None 0
Homo sapiens M3K5_HUMAN 2CLQA 2.3 Inactive DFGinter BABtrans out-out in-in STU Type1 670 - 940 None None 5
Homo sapiens M3K5_HUMAN 2CLQB 2.3 Inactive DFGinter BABtrans in-none in-in STU Type1 670 - 940 None None 8
Homo sapiens M3K5_HUMAN 8QGYA 3.71 Inactive DFGout None in-out in-none No_ligand No_ligand 95 - 940 None None 13

MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

No non-human structures known.