NEK7 (Serine/threonine-protein kinase Nek7)

Group: NEK
Uniprot: NEK7_HUMAN
Domain boundary: 34 - 294


Total number of chains: 34
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q8TDX7-K1A
DFGin None 19 6S73A
DFGout BBAminus 2 8WS0B
DFGout None 7 8SXNA
None None 5 6S76A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q8TDX7-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 26 - 302 None None 0
8EJ4K 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4L 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4M 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4N 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4O 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4P 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4Q 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4R 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4S 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
8EJ4T 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
2WQMA 2.1 Inactive DFGin None out-out none-none No_ligand No_ligand 20 - 300 None None 18
6S76B 3.38 Inactive DFGin None out-none none-out No_ligand No_ligand 20 - 300 None None 14
6S76C 3.38 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 300 None None 17
6S73A 3.5 Inactive DFGin None out-none out-out F9N Type1 21 - 300 L86H,Y97F,L180F None 11
6S73B 3.5 Inactive DFGin None out-out none-out F9N Type1 20 - 300 L86H,Y97F,L180F None 13
6S73C 3.5 Inactive DFGin None out-none none-none F9N Type1 26 - 300 L86H,Y97F,L180F None 16
2WQNA 2.3 Inactive DFGin None out-out none-none ADP Type1 21 - 300 None None 18
6S75B 3.3 Inactive DFGin None out-none none-out F9N Type1 20 - 300 None None 14
6S75C 3.3 Inactive DFGin None out-none none-none F9N Type1 22 - 300 None None 16
8WS0B 2.12 Inactive DFGout BBAminus out-out out-none No_ligand No_ligand 19 - 299 S195D None 11
8WS1B 2.4 Inactive DFGout BBAminus out-out out-none No_ligand No_ligand 20 - 300 D161N None 11
5DE2A 2.78 Inactive DFGout None out-out none-out No_ligand No_ligand 20 - 300 Y97F None 14
6S75D 3.3 Inactive DFGout None out-none none-none No_ligand No_ligand 28 - 299 None None 18
8WS0A 2.12 Inactive DFGout None out-out out-none No_ligand No_ligand 20 - 300 S195D None 14
8SXNA 4.04 Inactive DFGout None out-none out-out No_ligand No_ligand 19 - 302 None None 0
8SXNB 4.04 Inactive DFGout None out-none out-out No_ligand No_ligand 19 - 302 None None 0
8WS1A 2.4 Inactive DFGout None out-out out-none No_ligand No_ligand 20 - 300 D161N None 13
6S75A 3.3 Inactive DFGout None out-none none-none F9N Type1 19 - 300 None None 15
6NPYB 3.8 Inactive None None none-none none-none No_ligand No_ligand 113 - 300 L54R,V58K,P59T,K87A,A99V,S100C,E103T,D104G None 18
5DE2B 2.78 Inactive None None out-out none-none No_ligand No_ligand 20 - 300 Y97F None 19
6S73D 3.5 Inactive None None out-none none-none No_ligand No_ligand 23 - 300 L86H,Y97F,L180F None 19
6S76A 3.38 Inactive None None out-none none-out No_ligand No_ligand 21 - 300 None None 14
6S76D 3.38 Inactive None None out-none none-none No_ligand No_ligand 25 - 300 None None 18

NEK7 (Serine/threonine-protein kinase Nek7)

Group: NEK
Total number of chains: 34
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q8TDX7-K1A
DFGin None 19 6S73A
DFGout BBAminus 2 8WS0B
DFGout None 7 8SXNA
None None 5 6S76A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens NEK7_HUMAN AF-Q8TDX7-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 26 - 302 None None 0
Homo sapiens NEK7_HUMAN 8EJ4K 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4L 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4M 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4N 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4O 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4P 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4Q 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4R 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4S 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 8EJ4T 3.4 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 297 None None 17
Homo sapiens NEK7_HUMAN 2WQMA 2.1 Inactive DFGin None out-out none-none No_ligand No_ligand 20 - 300 None None 18
Homo sapiens NEK7_HUMAN 6S76B 3.38 Inactive DFGin None out-none none-out No_ligand No_ligand 20 - 300 None None 14
Homo sapiens NEK7_HUMAN 6S76C 3.38 Inactive DFGin None out-none none-none No_ligand No_ligand 20 - 300 None None 17
Homo sapiens NEK7_HUMAN 6S73A 3.5 Inactive DFGin None out-none out-out F9N Type1 21 - 300 L86H,Y97F,L180F None 11
Homo sapiens NEK7_HUMAN 6S73B 3.5 Inactive DFGin None out-out none-out F9N Type1 20 - 300 L86H,Y97F,L180F None 13
Homo sapiens NEK7_HUMAN 6S73C 3.5 Inactive DFGin None out-none none-none F9N Type1 26 - 300 L86H,Y97F,L180F None 16
Homo sapiens NEK7_HUMAN 2WQNA 2.3 Inactive DFGin None out-out none-none ADP Type1 21 - 300 None None 18
Homo sapiens NEK7_HUMAN 6S75B 3.3 Inactive DFGin None out-none none-out F9N Type1 20 - 300 None None 14
Homo sapiens NEK7_HUMAN 6S75C 3.3 Inactive DFGin None out-none none-none F9N Type1 22 - 300 None None 16
Homo sapiens NEK7_HUMAN 8WS0B 2.12 Inactive DFGout BBAminus out-out out-none No_ligand No_ligand 19 - 299 S195D None 11
Homo sapiens NEK7_HUMAN 8WS1B 2.4 Inactive DFGout BBAminus out-out out-none No_ligand No_ligand 20 - 300 D161N None 11
Homo sapiens NEK7_HUMAN 5DE2A 2.78 Inactive DFGout None out-out none-out No_ligand No_ligand 20 - 300 Y97F None 14
Homo sapiens NEK7_HUMAN 6S75D 3.3 Inactive DFGout None out-none none-none No_ligand No_ligand 28 - 299 None None 18
Homo sapiens NEK7_HUMAN 8WS0A 2.12 Inactive DFGout None out-out out-none No_ligand No_ligand 20 - 300 S195D None 14
Homo sapiens NEK7_HUMAN 8SXNA 4.04 Inactive DFGout None out-none out-out No_ligand No_ligand 19 - 302 None None 0
Homo sapiens NEK7_HUMAN 8SXNB 4.04 Inactive DFGout None out-none out-out No_ligand No_ligand 19 - 302 None None 0
Homo sapiens NEK7_HUMAN 8WS1A 2.4 Inactive DFGout None out-out out-none No_ligand No_ligand 20 - 300 D161N None 13
Homo sapiens NEK7_HUMAN 6S75A 3.3 Inactive DFGout None out-none none-none F9N Type1 19 - 300 None None 15
Homo sapiens NEK7_HUMAN 6NPYB 3.8 Inactive None None none-none none-none No_ligand No_ligand 113 - 300 L54R,V58K,P59T,K87A,A99V,S100C,E103T,D104G None 18
Homo sapiens NEK7_HUMAN 5DE2B 2.78 Inactive None None out-out none-none No_ligand No_ligand 20 - 300 Y97F None 19
Homo sapiens NEK7_HUMAN 6S73D 3.5 Inactive None None out-none none-none No_ligand No_ligand 23 - 300 L86H,Y97F,L180F None 19
Homo sapiens NEK7_HUMAN 6S76A 3.38 Inactive None None out-none none-out No_ligand No_ligand 21 - 300 None None 14
Homo sapiens NEK7_HUMAN 6S76D 3.38 Inactive None None out-none none-none No_ligand No_ligand 25 - 300 None None 18

NEK7 (Serine/threonine-protein kinase Nek7)

No non-human structures known.