Ligand: MM8

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 50.0% 6T6DB
DFGin BLAminus 1 25.0% 6T6DD
DFGin None 1 25.0% 6T6DA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL ACVR1 ACVR1_HUMAN 6T6DB 2.56 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi MM8 Type1 203 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DC 2.56 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 205 - 498 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DD 2.56 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii MM8 Type1 203 - 498 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DA 2.56 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 204 - 499 0 None Q207D Activin receptor type-1

Ligand: MM8

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 50.0% 6T6DB
DFGin BLAminus 1 25.0% 6T6DD
DFGin None 1 25.0% 6T6DA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL ACVR1 ACVR1_HUMAN 6T6DB 2.56 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi MM8 Type1 203 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6T6DC 2.56 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 205 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6T6DD 2.56 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii MM8 Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6T6DA 2.56 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens

Ligand: MM8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism