All / DFGinNone / All

Total number of chains: 673
Active chains: 0
Total number of genes: 111
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 673 100.0% 9H8FA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC GRK2 ARBK1_HUMAN 3CIKA P25098 29 669 689.0 No_ligand No_ligand Inactive DFGin 5.2003 12.94 None -113.38, -84.39 -77.41, 106.5 -85.28, 5.55 272.59, 132.44 -54.41, -34.31 in-in in 8.589 Saltbr-in 2.8304 HRD-in -65.15, -43.87 69.81, -16.37 in-in-in SNCiii in-in ActLoopNT-in 2.8246 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.98, 126.35 APE9-dihe-na 141.75, -159.25 APE8-dihe-in -111.86, 146.5 APE8-rot-in 310.14 APE67-dihe-in -81.13, 3.2 -68.81, -30.14 APE12-dist-in 10.9775 APE11-dist-in 12.0726 APE10-dist-in 6.4171 APE9-dist-in 3.5873 None None None XRAY 2.75 0.208 0.269 A 689.0 619.0 0 26 26 0 [[191, 453]] 1.0 3cik AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 7PWDA P25098 27 668 689.0 8DS:701 Type1 Inactive DFGin 5.2813 12.9593 None -103.27, -91.53 -83.38, 120.45 -98.95, 11.01 295.2, 164.91 -62.17, -28.84 in-in in 8.7988 Saltbr-in 2.8227 HRD-in -68.27, -51.69 76.81, -22.19 in-in-in SNCiii in-in ActLoopNT-in 2.8256 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.66, 145.62 APE9-dihe-na 123.25, -162.48 APE8-dihe-in -110.04, 138.42 APE8-rot-in 305.66 APE67-dihe-inflip 98.02, -22.76 -65.28, 137.62 APE12-dist-in 10.312 APE11-dist-in 11.9263 APE10-dist-in 6.0194 APE9-dist-in 3.3652 S670A None None XRAY 2.6 0.192 0.23 A 697.0 621.0 0 26 26 0 [[191, 453]] 1.0 7pwd AGC_GRK2_HUMAN AGC 6.4e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3KRWA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.4431 12.512 None -124.43, -69.99 -70.72, 103.06 -103.15, 18.82 281.61, 154.56 -63.74, -46.79 in-in in 8.9073 Saltbr-in 2.6208 HRD-in -80.35, -50.37 71.38, -3.06 in-in-in SNCiii in-in ActLoopNT-in 2.7506 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.68, 135.05 APE9-dihe-na 136.51, -178.33 APE8-dihe-in -97.44, 143.34 APE8-rot-in 311.93 APE67-dihe-in -81.84, -17.98 -65.75, -16.48 APE12-dist-in 9.7737 APE11-dist-in 11.7182 APE10-dist-in 5.7635 APE9-dist-in 3.2649 None None None XRAY 2.9 0.216 0.265 A 688.0 618.0 0 26 26 0 [[191, 453]] 1.0 3krw AGC_GRK2_HUMAN AGC 6.2e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3KRXA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.4192 12.8449 None -125.39, -77.94 -69.67, 105.65 -105.64, 33.0 281.38, 161.16 -76.22, -41.07 in-in in 9.1809 Saltbr-in 2.9453 HRD-in -81.43, -47.09 70.32, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.7468 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.75, 134.45 APE9-dihe-na 144.08, -171.31 APE8-dihe-in -102.11, 138.21 APE8-rot-in 300.04 APE67-dihe-in -91.64, -15.37 -61.65, -13.24 APE12-dist-in 9.2638 APE11-dist-in 11.5714 APE10-dist-in 5.62 APE9-dist-in 3.2776 None None None XRAY 3.1 0.232 0.27 A 688.0 618.0 0 26 26 0 [[191, 453]] 1.0 3krx AGC_GRK2_HUMAN AGC 6.2e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK5 GRK5_HUMAN 6PJXA P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.2367 11.8767 None -101.92, -82.66 -75.73, 114.06 -96.27, 14.0 297.14, 3.15 -60.02, -23.28 in-in in 8.7999 Saltbr-in 2.3601 HRD-in -81.73, -51.04 76.16, -8.97 in-in-in SNCiii in-in ActLoopNT-in 2.8132 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.38, 158.39 APE9-dihe-na 127.63, -164.44 APE8-dihe-in -112.45, 140.59 APE8-rot-in 303.57 APE67-dihe-inflip 81.94, -9.46 -52.3, 137.55 APE12-dist-in 9.8463 APE11-dist-in 11.9422 APE10-dist-in 6.1145 APE9-dist-in 4.4639 E104K,R304H,G438E None None XRAY 1.96 0.197 0.23 A 591.0 542.0 0 27 27 0 [[186, 448]] 1.0 6pjx AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.0198 12.8412 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.3335 Saltbr-in 3.3688 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.0372 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.1019 APE10-dist-in 6.3064 APE9-dist-in 4.1737 D311N None None XRAY 2.8 0.232 0.277 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 8uaq AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRFA P34947 25 542 590.0 A1AQ5:601 Type1 Inactive DFGin 6.2131 12.8852 None -116.13, -75.08 -76.38, 97.42 -93.08, 20.96 275.91, 78.29 -67.65, -17.42 in-in in 9.0758 Saltbr-in 2.4746 HRD-in -89.29, -49.76 68.56, 5.65 in-in-in SNCiii in-in ActLoopNT-in 3.0583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.67, 152.28 APE9-dihe-na 135.63, -159.61 APE8-dihe-in -113.28, 137.14 APE8-rot-in 304.0 APE67-dihe-inflip 86.51, -10.19 -50.9, 134.51 APE12-dist-in 9.9844 APE11-dist-in 12.0653 APE10-dist-in 6.2254 APE9-dist-in 4.1192 D311N None None XRAY 2.84 0.224 0.277 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brf AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRIA P34947 25 542 590.0 A1AQ8:601 Type1 Inactive DFGin 5.7901 12.7141 None -118.56, -79.42 -70.93, 91.99 -85.99, 18.72 271.5, 67.77 -66.54, -25.08 in-in in 8.8021 Saltbr-in 2.6488 HRD-in -85.77, -46.41 67.52, 4.46 in-in-in SNCiii in-in ActLoopNT-in 3.1673 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.68, 145.74 APE9-dihe-na 145.19, -146.92 APE8-dihe-in -122.56, 141.77 APE8-rot-in 306.39 APE67-dihe-inflip 92.75, -9.14 -56.37, 130.7 APE12-dist-in 10.1331 APE11-dist-in 12.2149 APE10-dist-in 6.5714 APE9-dist-in 4.2246 D311N None None XRAY 2.9 0.217 0.26 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bri AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRJA P34947 25 542 590.0 A1AQ9:601 Type1 Inactive DFGin 5.7352 12.6187 None -115.77, -57.96 -84.12, 93.88 -92.94, 12.58 279.31, 72.41 -59.97, -23.3 in-in in 9.0567 Saltbr-in 2.377 HRD-in -83.8, -57.51 72.28, 3.71 in-in-in SNCiii in-in ActLoopNT-in 3.1163 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.79, 160.14 APE9-dihe-na 133.68, -150.07 APE8-dihe-in -119.54, 137.2 APE8-rot-in 310.18 APE67-dihe-inflip 98.77, -19.66 -54.34, 129.82 APE12-dist-in 9.7235 APE11-dist-in 12.1088 APE10-dist-in 6.4144 APE9-dist-in 4.1673 D311N None None XRAY 2.8 0.239 0.273 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brj AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PRKCB KPCB_HUMAN 9S9TA P05771 340 667 671.0 LY4:60701 Type1 Inactive DFGin 6.0927 13.9734 None -111.78, -89.62 -67.76, 129.93 -115.94, 12.83 282.89, 115.63 -69.35, -46.77 in-in in 8.5218 Saltbr-in 2.7226 HRD-in -57.71, -56.78 85.18, -40.4 in-in-in SNCiii in-in ActLoopNT-in 3.456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.66, 131.78 APE9-dihe-na 176.22, -177.75 APE8-dihe-in -90.0, 133.29 APE8-rot-in 321.38 APE67-dihe-in -84.35, -33.13 -46.48, -38.11 APE12-dist-in 8.3134 APE11-dist-in 11.686 APE10-dist-in 5.7522 APE9-dist-in 4.3402 D427N TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.425 0.218 0.29 A 353.0 315.0 0 28 28 0 [[342, 600]] 1.0 9s9t AGC_PRKCB_HUMAN AGC 1.3e-97 332.0 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC ROCK1 ROCK1_HUMAN 3TWJC Q13464 7 402 1354.0 07R:2 Type1 Inactive DFGin 8.7595 16.2726 None -145.99, 165.67 60.97, 69.02 -57.54, -10.47 212.34, 59.8 -68.93, 18.62 in-out in 7.7943 Saltbr-out 3.8223 HRD-in -73.44, -64.4 76.54, -16.94 out-out-out SNCooo out-out ActLoopNT-out 3.6487 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oiio APE10-dihe-na -174.55, 155.89 APE9-dihe-na -163.77, 151.18 APE8-dihe-out 67.81, 65.3 APE8-rot-in 318.87 APE67-dihe-in -61.73, -42.12 -68.66, -9.31 APE12-dist-out 6.7625 APE11-dist-in 8.2184 APE10-dist-in 6.2456 APE9-dist-out 9.0493 None None None XRAY 2.9 0.224 0.289 C 410.0 396.0 0 29 29 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1.0 260.0 260.0 215 216 217 219 221 105 124 128 195 197 196 198.0 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 5U7RD O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.9914 13.6381 None -137.02, -44.53 -96.66, 83.52 -88.69, 16.85 303.92, 107.42 -55.18, -36.04 in-in in 8.7331 Saltbr-in 2.7396 HRD-in -81.59, -27.48 68.65, -73.51 in-in-out SNCiio in-out ActLoopNT-in 3.0332 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -137.68 APE8-dihe-in -113.15, 136.27 APE8-rot-out 64.84 APE67-dihe-in -28.57, -52.13 -70.74, -29.02 APE12-dist-out 6.8435 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7119 None None None XRAY 3.33 0.202 0.241 D 395.0 382.0 5 29 27 2 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA P51812 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.6399 11.2827 None -75.51, -9.72 -147.12, 169.74 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.1812 APE11-dist-out 18.8341 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317.0 295.0 9 28 26 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.8283 11.217 None -75.62, -9.94 -146.57, 168.73 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.1321 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.6928 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317.0 293.0 10 28 26 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.7417 11.3154 None -74.55, -8.16 -143.05, 166.95 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.2243 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.6879 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317.0 292.0 11 28 25 3 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.7434 11.0548 None -76.12, -10.81 -146.65, 168.53 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.9521 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.1175 APE11-dist-out 17.3774 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317.0 293.0 10 28 26 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.9835 11.2516 None -84.57, 1.64 -160.36, 173.95 -140.73, 41.08 33.77, 88.9 86.89, 20.77 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.55, -32.96 78.36, -52.1 none-out-out SNCnoo out-out ActLoopNT-out 9.9576 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.72, -148.34 APE9-dihe-na -103.74, -158.66 APE8-dihe-in -91.11, 113.9 APE8-rot-in 297.76 APE67-dihe-in -53.19, -20.32 -55.54, -41.19 APE12-dist-in 13.7321 APE11-dist-out 15.8714 APE10-dist-out 13.5037 APE9-dist-in 5.5319 None None None XRAY 2.499 0.188 0.233 A 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g77 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.612 11.3114 None -84.74, -2.79 -145.41, 176.89 -143.69, 39.64 45.89, 82.52 94.84, 15.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.95, -30.79 74.87, -47.1 none-out-out SNCnoo out-out ActLoopNT-out 10.0706 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.75, -144.28 APE9-dihe-na -119.2, -153.74 APE8-dihe-in -83.74, 120.03 APE8-rot-in 297.54 APE67-dihe-in -52.98, -34.42 -57.71, -42.71 APE12-dist-in 13.9149 APE11-dist-out 16.0857 APE10-dist-out 13.633 APE9-dist-in 5.5223 None None None XRAY 2.499 0.188 0.233 B 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g77 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KB1 KS6B1_HUMAN 4RLOA P23443 85 371 525.0 3T3:401 Type1 Inactive DFGin 5.2698 12.7473 None -131.54, -63.42 -88.2, 143.06 -127.47, 172.78 303.39, 172.08 126.01, -46.31 in-in in 7.6982 Saltbr-in 2.3003 HRD-in -57.89, -55.64 79.38, -25.61 in-in-out SNCiio in-out ActLoopNT-in 3.2859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.78 APE8-dihe-in -54.68, 162.27 APE8-rot-out 190.34 APE67-dihe-in -62.73, -12.73 -141.73, -3.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 30.2221 None None None XRAY 2.527 0.193 0.222 A 288.0 259.0 28 28 16 12 [[91, 352]] 1.0 4rlo AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A P23443 85 371 525.0 STU:400 Type1 Inactive DFGin 6.1574 13.694 None -106.91, -67.93 -78.35, 124.27 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.7541 Saltbr-out 3.9045 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327.0 263.0 24 28 15 13 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A P23443 87 371 525.0 STU:400 Type1 Inactive DFGin 5.8125 13.4055 None -134.05, -75.4 -81.48, 111.28 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.8631 Saltbr-in 3.4595 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9635 None None None XRAY 3.43 0.274 0.349 A 327.0 254.0 31 28 12 16 [[91, 352]] 1.0 3a61 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WF7A P23443 83 374 525.0 FS9:402 Type1 Inactive DFGin 6.6625 14.9899 None -128.93, -10.26 -99.96, 98.47 -129.8, 160.96 298.66, 90.56 73.54, -129.51 out-out out 14.17 Saltbr-out 10.1405 HRD-in -80.11, -34.14 77.1, -48.65 out-out-out SNCooo out-out ActLoopNT-out 12.9719 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -70.88, 130.47 APE9-dihe-na 74.33, -175.83 APE8-dihe-in -68.5, 140.34 APE8-rot-out 182.72 APE67-dihe-in -64.92, -16.71 -105.43, 9.18 APE12-dist-in 11.9606 APE11-dist-out 14.4376 APE10-dist-out 10.0149 APE9-dist-out 11.9861 None TPO252 TPO252 XRAY 1.85 0.175 0.224 A 329.0 289.0 3 28 25 3 [[91, 352]] 1.0 3wf7 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC STK38 STK38_HUMAN 6BXIA Q15208 82 414 465.0 ANP:501 ATPlike Inactive DFGin 7.6243 15.2423 None -66.11, 165.54 -58.06, 132.91 -140.43, 160.91 66.01, 93.84 127.58, -39.07 out-out out 17.2238 Saltbr-out 15.8035 HRD-out -81.74, 95.52 -90.45, 26.47 out-out-out SNCooo out-out ActLoopNT-out 8.4633 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.6, -60.62 APE9-dihe-na 67.05, -156.06 APE8-dihe-in -145.17, 163.6 APE8-rot-out 65.89 APE67-dihe-in -50.28, -35.19 -91.75, 25.88 APE12-dist-out 17.3379 APE11-dist-out 14.2084 APE10-dist-out 17.7703 APE9-dist-out 12.1009 None None None XRAY 2.2 0.173 0.212 A 333.0 333.0 0 63 63 0 [[89, 382]] 1.0 6bxi AGC_STK38_HUMAN AGC 2.8e-98 334.1 1.0 260.0 260.0 229 230 231 233 235 118 137 141 209 211 210 212.0 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB Q15208 83 414 465.0 ANP:501 ATPlike Inactive DFGin 7.5828 15.1791 None -72.08, 165.13 -53.35, 130.13 -138.87, 159.98 66.77, 96.29 126.01, -39.3 out-out out 17.1655 Saltbr-out 16.0645 HRD-out -84.3, 107.68 -100.32, 27.31 out-out-out SNCooo out-out ActLoopNT-out 8.4877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.07, -63.08 APE9-dihe-na 73.07, -157.98 APE8-dihe-in -144.12, 160.82 APE8-rot-out 65.98 APE67-dihe-in -53.15, -35.39 -88.29, 27.93 APE12-dist-out 17.2389 APE11-dist-out 14.1835 APE10-dist-out 17.7413 APE9-dist-out 12.0524 None None None XRAY 2.2 0.173 0.212 B 333.0 332.0 0 63 63 0 [[89, 382]] 1.0 6bxi AGC_STK38_HUMAN AGC 2.8e-98 334.1 1.0 260.0 260.0 229 230 231 233 235 118 137 141 209 211 210 212.0 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
CAMK AURKA AURKA_HUMAN 4C3PA O14965 125 388 403.0 ACP:1389 ATPlike Inactive DFGin 5.1209 15.3112 None -143.16, 44.14 -117.33, -72.7 63.16, 22.36 309.54, 103.5 -71.05, -27.42 out-out out 10.7129 Saltbr-out 4.9547 HRD-out -79.39, 150.41 -121.39, -68.05 out-in-out SNCoio in-out ActLoopNT-in 2.8189 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -49.34, 122.38 APE9-dihe-na 116.03, -35.9 APE8-dihe-out -100.65, -0.54 APE8-rot-out 177.69 APE67-dihe-in -57.5, -32.82 -45.19, -41.29 APE12-dist-out 20.9276 APE11-dist-out 21.1759 APE10-dist-out 26.1561 APE9-dist-out 28.5914 None None None XRAY 2.69 0.205 0.289 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 4c3p CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6DA O14965 126 390 403.0 ANP:61391 ATPlike Inactive DFGin 6.2574 16.4224 None -70.12, 150.14 -40.51, 101.21 -55.1, 131.85 61.77, 102.87 98.63, -164.78 out-out out 13.1601 Saltbr-out 13.9978 HRD-out -91.98, 166.93 -128.47, 87.17 out-out-out SNCooo out-out ActLoopNT-out 17.9333 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.8 APE8-dihe-in -71.63, 167.98 APE8-rot-out 60.54 APE67-dihe-in -57.74, -18.95 -51.64, -36.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0437 None None None XRAY 2.2 0.23 0.28 A 275.0 255.0 10 26 16 10 [[133, 383]] 1.0 2c6d CAMK_AURKA_HUMAN CAMK 1.5e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ODTA O14965 126 392 403.0 ADP:501 ATPlike Inactive DFGin 6.7171 16.9598 None -121.13, 4.47 -111.78, 32.81 -79.52, 164.76 286.94, 96.78 78.48, -128.28 out-out out 11.7478 Saltbr-out 10.767 HRD-out -137.93, 83.59 -73.55, -34.72 out-out-out SNCooo out-out ActLoopNT-out 17.7885 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -15.28 APE9-dihe-na -98.55, 177.35 APE8-dihe-out 65.78, -46.63 APE8-rot-none 999.0 APE67-dihe-in -47.55, -29.4 -45.89, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.8668 APE9-dist-out 13.4366 D274N,C290A,C393A None None XRAY 2.021 0.179 0.211 A 283.0 258.0 9 26 17 9 [[133, 383]] 1.0 5odt CAMK_AURKA_HUMAN CAMK 5.4e-78 267.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBJA O14965 127 390 403.0 ATP:404,9QK:405 ATPlike,Allosteric Inactive DFGin 6.016 15.9671 None -127.31, -156.34 57.9, -96.92 69.6, 25.6 277.68, 99.91 -74.82, -34.09 out-out out 10.8688 Saltbr-out 3.9746 HRD-in -84.35, -43.15 67.43, 1.86 out-in-out SNCoio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -85.06 APE9-dihe-na -106.73, -153.17 APE8-dihe-in -86.88, 144.13 APE8-rot-in 279.73 APE67-dihe-in -52.07, -35.29 -66.02, -11.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3791 APE9-dist-out 10.1992 None None None XRAY 2.901 0.215 0.245 A 272.0 260.0 4 26 22 4 [[133, 383]] 1.0 5obj CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.1772 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.8811 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7077 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285.0 256.0 12 26 14 12 [[133, 383]] 1.0 9guc CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8JF4A O14965 127 389 403.0 C0N:401 Type1 Inactive DFGin 7.2529 17.8729 None -135.45, -161.79 63.9, -97.55 64.54, 6.09 245.37, 117.13 -63.89, -23.61 out-none out 12.6402 Saltbr-none 999.0 HRD-out -120.1, 149.54 -137.31, -168.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -130.74 APE9-dihe-na -95.79, -164.69 APE8-dihe-in -61.45, 121.57 APE8-rot-in 284.06 APE67-dihe-in -41.63, -35.05 -74.97, -8.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.8848 APE9-dist-out 12.0317 None None None XRAY 2.893 0.241 0.3 A 263.0 252.0 11 26 15 11 [[133, 383]] 1.0 8jf4 CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8JMXA O14965 127 389 403.0 E47:401 Type1 Inactive DFGin 8.1479 17.9382 None -66.97, -135.61 -86.55, 178.72 -114.61, 4.13 278.35, 26.61 128.02, 999.0 out-none out 12.4603 Saltbr-none 999.0 HRD-out -175.92, -143.93 -146.96, -121.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, -148.55 APE9-dihe-na -86.45, -174.61 APE8-dihe-out -81.39, -14.34 APE8-rot-out 176.74 APE67-dihe-out -64.27, -11.38 79.63, -40.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3418 None None None XRAY 2.95 0.231 0.306 A 263.0 250.0 13 26 13 13 [[133, 383]] 1.0 8jmx CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7AYIA O14965 125 392 403.0 S9K:501 Type1 Inactive DFGin 5.4193 15.6223 None -144.41, -177.78 68.28, 27.25 -31.37, 999.0 286.89, 77.45 999.0, 999.0 out-out out 11.6263 Saltbr-out 5.2735 HRD-out -134.3, 170.16 -127.02, -53.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -25.37 APE8-rot-out 50.94 APE67-dihe-in -37.9, -35.61 -58.22, -27.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.254 0.297 A 285.0 252.0 16 26 10 16 [[133, 383]] 1.0 7ayi CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J4ZB O14965 126 395 403.0 626:1395 Type1 Inactive DFGin 4.2178 13.6848 None -135.88, 74.16 -114.29, 33.41 -89.42, 114.89 302.17, 82.01 -8.53, 159.28 out-out out 11.4154 Saltbr-out 7.1624 HRD-out 58.44, 64.77 -95.37, 159.29 out-out-out SNCooo out-out ActLoopNT-out 18.7148 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -94.91, -9.28 APE9-dihe-na 130.48, -157.55 APE8-dihe-in -66.91, 118.34 APE8-rot-in 305.65 APE67-dihe-in -61.18, -13.87 -47.83, -58.47 APE12-dist-out 16.9419 APE11-dist-out 16.0005 APE10-dist-out 16.5324 APE9-dist-out 8.9625 None None None XRAY 2.0 0.214 0.249 B 306.0 270.0 0 26 26 0 [[133, 383]] 1.0 2j4z CAMK_AURKA_HUMAN CAMK 9.9e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0WA O14965 125 391 403.0 ADN:501 Type1 Inactive DFGin 6.2719 16.5981 None -99.25, -54.63 -80.04, -74.28 72.86, -1.54 279.35, 93.09 -53.76, -20.49 out-out out 11.3192 Saltbr-out 4.9936 HRD-in -77.36, -61.61 76.79, -35.67 out-in-out SNCoio in-out ActLoopNT-in 2.7811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -96.78, 99.9 APE9-dihe-na 173.74, 169.14 APE8-dihe-in -81.74, 143.07 APE8-rot-out 200.15 APE67-dihe-in -47.45, -41.6 -91.34, -9.3 APE12-dist-none 999.0 APE11-dist-in 12.2482 APE10-dist-out 14.98 APE9-dist-out 11.7548 H254Y None None XRAY 2.6 0.246 0.277 A 282.0 259.0 8 26 18 8 [[133, 383]] 1.0 4o0w CAMK_AURKA_HUMAN CAMK 1.5e-78 269.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H0ZA O14965 128 388 403.0 45B:1 Type1 Inactive DFGin 7.3472 16.083 None -89.96, 161.55 64.52, -172.92 -163.13, -57.24 280.93, 123.29 171.24, 120.64 out-out out 10.3185 Saltbr-out 7.3796 HRD-out -71.52, 144.0 -92.02, -55.66 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.34 APE8-rot-out 164.31 APE67-dihe-in -55.12, -32.9 -104.49, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.92 0.221 0.286 A 268.0 248.0 13 26 13 13 [[133, 383]] 1.0 3h0z CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DHFA O14965 128 389 403.0 0K6:401 Type1 Inactive DFGin 6.0606 15.9561 None -124.92, -165.4 70.7, -102.39 69.61, 140.83 290.26, 89.34 63.95, 95.41 in-in in 8.9889 Saltbr-in 2.893 HRD-in -73.28, -47.83 72.66, -2.67 in-in-out SNCiio in-out ActLoopNT-in 3.5586 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -6.14 APE9-dihe-na -59.01, 54.1 APE8-dihe-out 19.82, 17.91 APE8-rot-out 105.73 APE67-dihe-out -28.21, -43.1 61.5, -49.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7292 APE9-dist-out 7.9962 T287D,T288D None None XRAY 2.8 0.21 0.299 A 271.0 258.0 4 26 22 4 [[133, 383]] 1.0 4dhf CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DHFB O14965 128 389 403.0 0K6:401 Type1 Inactive DFGin 6.2133 16.1482 None -129.3, -166.63 71.78, -102.87 78.31, 163.45 277.6, 93.12 43.8, 85.35 in-in in 9.3755 Saltbr-in 3.1006 HRD-in -78.27, -44.01 67.72, -6.17 in-in-out SNCiio in-out ActLoopNT-in 2.9195 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -62.03 APE9-dihe-na -175.18, -54.66 APE8-dihe-out 61.81, -74.57 APE8-rot-out 81.7 APE67-dihe-out -53.34, -26.37 96.06, -28.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.9693 APE9-dist-out 10.0958 T287D,T288D None None XRAY 2.8 0.21 0.299 B 271.0 258.0 4 26 22 4 [[133, 383]] 1.0 4dhf CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4PRJA O14965 125 388 403.0 2VU:401 Type1 Inactive DFGin 5.9517 15.2568 None -87.9, -78.85 -67.3, 132.08 -130.02, 25.75 273.54, 81.31 -60.0, -22.81 in-in in 9.9032 Saltbr-in 3.107 HRD-in -70.35, -53.13 72.43, -26.65 in-in-out SNCiio in-out ActLoopNT-in 3.0892 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 60.06 APE9-dihe-na -85.89, -100.42 APE8-dihe-in -76.32, 127.81 APE8-rot-out 186.15 APE67-dihe-out -49.54, 145.49 -72.25, -20.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5199 APE9-dist-out 11.3043 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None None XRAY 2.8 0.233 0.275 A 269.0 251.0 13 26 16 10 [[133, 383]] 1.0 4prj CAMK_AURKA_HUMAN CAMK 6.9e-79 270.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5AAEA O14965 126 388 403.0 7HD:1389 Type1 Inactive DFGin 5.9398 15.1503 None -95.89, -104.86 -82.25, 148.83 -122.78, 23.14 291.0, 74.49 -53.63, -36.45 out-none out 10.8697 Saltbr-none 999.0 HRD-in -83.0, -21.45 60.1, -65.55 none-in-out SNCnio in-out ActLoopNT-in 3.0061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -177.84 APE8-dihe-in -88.91, 121.07 APE8-rot-out 73.44 APE67-dihe-in -49.15, -25.21 -87.19, -36.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0803 C290A,C393A None None XRAY 3.11 0.241 0.291 A 285.0 252.0 11 26 15 11 [[133, 383]] 1.0 5aae CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0UA O14965 126 391 403.0 ADN:501 Type1 Inactive DFGin 6.2642 11.4304 None -100.67, -17.12 -134.58, 129.02 -80.64, -37.58 28.72, 51.86 64.49, -126.4 out-out out 12.2241 Saltbr-out 10.2319 HRD-out -138.46, 154.69 -78.12, -46.1 out-in-out SNCoio in-out ActLoopNT-in 3.5193 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.11, -47.49 APE9-dihe-na -96.12, 155.1 APE8-dihe-in -73.36, 140.7 APE8-rot-out 180.88 APE67-dihe-in -47.54, -36.76 -84.86, -11.52 APE12-dist-out 18.1413 APE11-dist-out 15.8917 APE10-dist-out 13.345 APE9-dist-out 11.2984 H254R None None XRAY 2.6 0.236 0.273 A 282.0 259.0 7 26 19 7 [[133, 383]] 1.0 4o0u CAMK_AURKA_HUMAN CAMK 3.5e-78 268.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDA O14965 127 388 403.0 QMN:1389 Type1.5_Front Inactive DFGin 4.7703 14.7373 None -129.81, 37.03 -50.55, -31.01 -53.57, 125.59 325.32, 89.96 118.13, 999.0 out-out out 11.6146 Saltbr-out 8.8418 HRD-out 53.57, 64.67 -94.14, 134.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -65.57, -29.93 APE9-dihe-na 142.25, -148.89 APE8-dihe-in -77.46, 105.91 APE8-rot-in 292.33 APE67-dihe-in -60.25, -12.9 -39.34, -60.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.5975 None None None XRAY 3.2 0.215 0.262 A 287.0 254.0 8 26 18 8 [[133, 383]] 1.0 4uzd CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDB O14965 125 389 403.0 QMN:1390 Type1.5_Front Inactive DFGin 4.5757 14.7196 None -129.5, 39.33 -48.31, -42.14 -43.39, 138.93 326.34, 95.13 97.81, -168.36 out-out out 11.585 Saltbr-out 9.3972 HRD-out 50.88, 59.12 -92.12, 140.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.7, -29.88 APE9-dihe-na 143.96, -147.24 APE8-dihe-in -77.35, 106.49 APE8-rot-in 291.41 APE67-dihe-in -62.64, -12.41 -49.18, -49.73 APE12-dist-out 16.5866 APE11-dist-out 15.4049 APE10-dist-out 16.5271 APE9-dist-out 9.5026 None None None XRAY 3.2 0.215 0.262 B 287.0 258.0 7 26 19 7 [[133, 383]] 1.0 4uzd CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UYNA O14965 125 391 403.0 Y3M:1392 Type1.5_Front Inactive DFGin 4.6948 14.0105 None -129.71, 33.27 -11.88, -124.06 104.64, 86.61 36.8, 56.54 29.97, 999.0 out-out out 11.4313 Saltbr-out 9.4418 HRD-out 56.55, 66.12 -91.27, 149.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.31, -27.51 999.0, -36.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.201 0.234 A 287.0 249.0 18 26 10 16 [[133, 383]] 1.0 4uyn CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK1D KCC1D_HUMAN 6QP5A Q8IU85 13 302 385.0 No_ligand No_ligand Inactive DFGin 6.6925 11.1697 None -82.96, -28.34 -164.68, 155.1 -154.96, 145.85 57.53, 95.92 -69.69, 999.0 out-out out 13.9124 Saltbr-out 9.5859 HRD-in -71.62, -51.72 69.89, 0.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.85, -19.27 999.0, -54.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.194 0.227 A 322.0 266.0 24 27 10 17 [[23, 279]] 1.0 6qp5 CAMK_CAMK1D_HUMAN CAMK 1.9e-99 338.2 1.0 256.0 256.0 164 165 166 168 170 52 69 73 141 143 142 144.0 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T28AAA Q8IU85 12 302 385.0 M92:407 Type1 Inactive DFGin 6.5698 11.3307 None -90.4, -16.76 -161.18, 147.37 -157.44, 158.53 66.3, 87.4 -95.47, 145.18 out-out out 13.7626 Saltbr-out 10.1987 HRD-in -66.33, -53.1 75.23, -5.6 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.8, -20.73 999.0, -50.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.55 0.159 0.183 AAA 385.0 271.0 20 27 11 16 [[23, 279]] 1.0 6t28 CAMK_CAMK1D_HUMAN CAMK 3.3e-99 337.4 1.0 256.0 256.0 164 165 166 168 170 52 69 73 141 143 142 144.0 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 8BFSA Q8IU85 12 302 385.0 QNR:402 Type1 Inactive DFGin 6.6093 11.2575 None -91.07, -14.07 -169.4, 138.32 -147.41, 155.24 57.99, 100.54 -87.18, 999.0 out-out out 13.8364 Saltbr-out 10.5309 HRD-in -62.95, -53.35 75.46, -6.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.41, -10.62 999.0, -62.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.168 0.202 A 385.0 274.0 17 27 10 17 [[23, 279]] 1.0 8bfs CAMK_CAMK1D_HUMAN CAMK 3.3e-99 337.4 1.0 256.0 256.0 164 165 166 168 170 52 69 73 141 143 142 144.0 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 8BFMA Q8IU85 12 301 385.0 QI6:403,QI6:404 Type1,Type3 Inactive DFGin 8.5628 12.6287 None -103.99, -11.66 -163.82, 149.21 -127.97, 160.23 291.25, 61.5 -121.89, 999.0 out-none out 12.8717 Saltbr-none 999.0 HRD-in -69.53, -51.54 74.1, -4.57 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -54.11 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.201 0.224 A 385.0 265.0 25 27 9 18 [[23, 279]] 1.0 8bfm CAMK_CAMK1D_HUMAN CAMK 3.3e-99 337.4 1.0 256.0 256.0 164 165 166 168 170 52 69 73 141 143 142 144.0 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1G KCC1G_HUMAN 2JAMA Q96NX5 18 302 476.0 J60:61305 Type1 Inactive DFGin 6.5403 11.2135 None -126.22, -80.87 -87.21, 120.33 -158.04, 166.34 60.61, 89.98 86.24, -162.04 out-out out 12.3632 Saltbr-out 7.0937 HRD-out -65.72, -48.99 75.81, 136.04 out-out-out SNCooo out-out ActLoopNT-out 7.3145 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -125.89, 7.58 APE9-dihe-na 74.8, 27.03 APE8-dihe-in -122.46, 113.05 APE8-rot-out 60.16 APE67-dihe-inflip 103.53, 4.1 -79.6, 161.99 APE12-dist-out 17.4469 APE11-dist-out 19.3036 APE10-dist-out 17.0526 APE9-dist-out 17.1197 None None None XRAY 1.7 0.157 0.231 A 304.0 279.0 7 26 25 1 [[23, 277]] 1.0 2jam CAMK_CAMK1G_HUMAN CAMK 7e-95 323.2 2.0 256.0 255.0 163 164 165 167 169 52 68 72 140 142 141 143.0 201 189 184 183 182 181 180 179 178 98 Calcium/calmodulin-dependent protein kinase type 1G
CAMK CAMK1G KCC1G_HUMAN 2JAMB Q96NX5 16 301 476.0 J60:61305 Type1 Inactive DFGin 6.6771 11.1321 None -124.15, -81.0 -87.53, 122.59 -160.87, 165.0 62.22, 92.45 89.73, -167.15 out-out out 12.3898 Saltbr-out 7.1065 HRD-out -61.63, -52.62 77.62, 132.57 out-out-out SNCooo out-out ActLoopNT-out 7.2194 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -119.46, -1.64 APE9-dihe-na 72.11, 27.97 APE8-dihe-in -123.57, 111.56 APE8-rot-out 56.49 APE67-dihe-inflip 101.49, 1.14 -80.93, 163.71 APE12-dist-out 17.5476 APE11-dist-out 19.4414 APE10-dist-out 16.8632 APE9-dist-out 17.0823 None None None XRAY 1.7 0.157 0.231 B 304.0 280.0 7 26 25 1 [[23, 277]] 1.0 2jam CAMK_CAMK1G_HUMAN CAMK 7e-95 323.2 2.0 256.0 255.0 163 164 165 167 169 52 68 72 140 142 141 143.0 201 189 184 183 182 181 180 179 178 98 Calcium/calmodulin-dependent protein kinase type 1G
CAMK CHEK2 CHK2_HUMAN 3I6UB O96017 89 501 543.0 No_ligand No_ligand Inactive DFGin 6.1563 12.4796 None -142.78, 168.99 70.83, 76.16 -115.43, 999.0 26.14, 78.04 999.0, 999.0 out-none out 13.9532 Saltbr-none 999.0 HRD-in -61.77, -58.18 77.91, -11.36 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -48.92, -23.0 999.0, -21.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.0 0.247 0.28 B 419.0 376.0 37 27 9 18 [[220, 486]] 1.0 3i6u CAMK_CHEK2_HUMAN CAMK 6.3e-84 287.4 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WA O96017 92 501 543.0 No_ligand No_ligand Inactive DFGin 7.3486 13.5162 None -131.02, -176.1 64.38, 89.31 -97.7, 999.0 302.36, 133.8 999.0, 999.0 out-none out 13.0764 Saltbr-none 999.0 HRD-in -64.4, -41.66 75.43, -23.93 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.49, -47.48 999.0, -37.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.25 0.252 0.287 A 443.0 369.0 41 27 9 18 [[220, 486]] 1.0 3i6w CAMK_CHEK2_HUMAN CAMK 7.4e-84 287.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WC O96017 92 501 543.0 No_ligand No_ligand Inactive DFGin 7.5775 13.998 None -131.8, -178.23 63.57, 98.9 -117.45, 999.0 335.54, 98.66 999.0, 999.0 out-none out 13.0805 Saltbr-none 999.0 HRD-in -63.6, -43.12 77.0, -24.17 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.04, -46.8 999.0, -37.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.25 0.252 0.287 C 443.0 368.0 42 27 9 18 [[220, 486]] 1.0 3i6w CAMK_CHEK2_HUMAN CAMK 7.4e-84 287.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WE O96017 92 501 543.0 No_ligand No_ligand Inactive DFGin 7.5459 13.6974 None -130.93, -177.05 65.38, 105.03 -130.22, 999.0 325.6, 106.63 999.0, 999.0 out-none out 13.0915 Saltbr-none 999.0 HRD-in -61.69, -42.13 73.77, -23.14 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.57, -46.22 999.0, -36.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.25 0.252 0.287 E 443.0 368.0 42 27 9 18 [[220, 486]] 1.0 3i6w CAMK_CHEK2_HUMAN CAMK 7.4e-84 287.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WG O96017 92 501 543.0 No_ligand No_ligand Inactive DFGin 7.5136 13.8031 None -131.95, -176.65 65.29, 79.69 -111.56, 999.0 332.1, 109.83 999.0, 999.0 out-none out 13.0784 Saltbr-none 999.0 HRD-in -62.8, -42.52 74.63, -23.4 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.54, -46.24 999.0, -36.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.25 0.252 0.287 G 443.0 369.0 41 27 9 18 [[220, 486]] 1.0 3i6w CAMK_CHEK2_HUMAN CAMK 7.4e-84 287.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK MARK2 MARK2_HUMAN 5KZ7A Q7KZI7 48 363 788.0 6Z2:401 Type1 Inactive DFGin 6.1798 15.1923 None -66.59, -98.89 -137.2, 177.34 -105.99, 0.84 306.21, 67.89 -39.62, 999.0 in-out in 9.3332 Saltbr-out 3.9373 HRD-in -57.93, -35.05 64.12, -16.36 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -56.94 APE8-rot-out 193.16 APE67-dihe-in -59.38, -16.94 -59.8, -39.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.226 0.293 A 346.0 296.0 20 27 11 16 [[53, 304]] 1.0 5kz7 CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_HUMAN 5KZ8A Q7KZI7 48 363 788.0 6Z5:401 Type1 Inactive DFGin 6.6608 14.8467 None -66.62, -138.3 -110.24, 161.57 -113.14, 60.74 323.38, 77.32 145.61, 999.0 in-out in 9.5893 Saltbr-out 4.8664 HRD-in -68.17, -39.88 60.26, -10.16 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 142.11 APE9-dihe-na -96.01, 39.12 APE8-dihe-out -76.41, -33.97 APE8-rot-out 180.16 APE67-dihe-in -71.46, -15.13 -73.47, -29.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5634 None None None XRAY 3.21 0.222 0.29 A 346.0 302.0 14 27 13 14 [[53, 304]] 1.0 5kz8 CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_HUMAN 5KZ8B Q7KZI7 48 363 788.0 6Z5:401 Type1 Inactive DFGin 7.4263 15.8016 None -67.43, 142.07 -36.53, 154.18 -125.77, 99.94 7.04, 147.55 143.09, 999.0 in-out in 9.6021 Saltbr-out 4.8858 HRD-in -66.11, -40.74 54.9, 7.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -66.07 APE8-rot-out 193.35 APE67-dihe-in -71.07, -14.96 -58.24, -27.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.21 0.222 0.29 B 346.0 300.0 16 27 11 16 [[53, 304]] 1.0 5kz8 CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK4 MARK4_HUMAN 5ES1A Q96L34 54 370 752.0 5RC:64000 Type1 Inactive DFGin 7.2886 14.3491 None -110.73, 167.87 94.58, -106.37 80.67, 9.01 291.5, 96.97 -62.77, -44.52 in-in in 9.1567 Saltbr-in 3.05 HRD-in -47.94, -47.33 60.65, 3.33 in-in-none SNCiin in-none ActLoopNT-in 3.2249 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.88 APE8-rot-none 999.0 APE67-dihe-in -54.77, -17.8 -67.3, -52.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.243 0.311 A 328.0 304.0 13 27 14 13 [[59, 310]] 1.0 5es1 CAMK_MARK4_HUMAN CAMK 2.4e-96 328.0 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
CAMK MELK MELK_HUMAN 5TWYA Q14680 2 333 651.0 7LY:64000 Type1 Inactive DFGin 6.2612 16.0842 None -134.84, -164.53 52.57, 45.85 -53.49, -63.86 258.25, 62.71 46.97, -72.76 out-out out 10.0719 Saltbr-out 4.1074 HRD-in -82.2, -30.32 67.57, -22.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.4 APE8-dihe-out -98.48, 8.41 APE8-rot-none 999.0 APE67-dihe-in -62.0, -32.92 -89.48, -29.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.225 None None None XRAY 2.91 0.288 0.33 A 341.0 311.0 21 29 14 15 [[11, 263]] 1.0 5twy CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 5MAIA Q14680 2 333 651.0 5U5:60402 Type1 Inactive DFGin 8.1092 15.0116 None -132.28, 170.97 62.08, 71.15 -94.74, 999.0 292.75, 79.84 999.0, 999.0 out-out out 11.8822 Saltbr-out 8.2222 HRD-in -86.33, -52.07 84.11, -4.76 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -42.92 APE8-rot-out 218.22 APE67-dihe-in -56.7, -25.99 -57.2, -38.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.192 0.237 A 347.0 311.0 19 29 10 19 [[11, 263]] 1.0 5mai CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MKNK2 MKNK2_HUMAN 2AC5A Q9HBH9 72 370 465.0 No_ligand No_ligand Inactive DFGin 5.9629 14.24 None 179.06, 141.31 141.75, -84.88 81.59, -68.22 316.67, 112.33 -126.47, 999.0 in-in in 9.4123 Saltbr-in 2.689 HRD-in -78.97, -46.18 65.28, 3.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -146.04, 164.66 APE9-dihe-na -132.94, -20.66 APE8-dihe-out -93.96, 15.45 APE8-rot-out 50.08 APE67-dihe-in -55.42, -30.57 -62.55, -42.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.5744 D228G None None XRAY 3.2 0.306 0.306 A 316.0 274.0 25 35 14 21 [[83, 368]] 1.0 2ac5 CAMK_MKNK2_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 225 226 227 229 231 113 129 133 202 204 203 205.0 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK MKNK2 MKNK2_HUMAN 8P9BA Q9HBH9 72 369 465.0 X8K:60402 Type1 Inactive DFGin 5.876 13.7919 None -150.06, 169.8 73.67, 48.24 -60.02, 999.0 327.08, 142.95 999.0, 999.0 in-in in 9.5716 Saltbr-in 2.6981 HRD-in -79.87, -54.07 80.13, -12.9 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.5 APE8-rot-none 999.0 APE67-dihe-in -71.68, -12.3 -89.2, -5.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D228G None None XRAY 2.59 0.211 0.264 A 316.0 262.0 36 35 10 25 [[83, 368]] 1.0 8p9b CAMK_MKNK2_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 225 226 227 229 231 113 129 133 202 204 203 205.0 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK PIM1 PIM1_HUMAN 4IAAA P11309 33 305 313.0 RTZ:401 Type1 Inactive DFGin 6.018 14.534 None -118.73, -143.64 -58.0, 140.84 -105.0, 12.55 279.89, 91.42 -63.74, -38.82 in-in in 8.9764 Saltbr-in 2.4263 HRD-naA -66.74, -45.93 76.57, 1.9 in-in-in SNCiii in-in ActLoopNT-in 2.8243 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.97, 36.36 APE9-dihe-na -102.7, -148.72 APE8-dihe-in -99.25, 120.44 APE8-rot-in 325.38 APE67-dihe-in -56.81, -14.63 -51.76, -61.55 APE12-dist-in 9.3212 APE11-dist-in 8.4746 APE10-dist-in 4.9412 APE9-dist-in 4.319 None SEP261 SEP261 XRAY 2.85 0.187 0.231 A 289.0 273.0 0 26 26 0 [[38, 290]] 1.0 4iaa CAMK_PIM1_HUMAN CAMK 3e-65 226.0 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4XH6A P11309 33 305 313.0 HUL:401 Type1 Inactive DFGin 6.0669 14.6256 None -113.12, -75.74 -81.94, 104.4 -86.86, 17.15 286.29, 78.0 -66.66, -16.93 in-in in 8.963 Saltbr-in 2.6759 HRD-naA -71.75, -47.81 68.98, 9.54 in-in-in SNCiii in-in ActLoopNT-in 2.8264 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.53, 35.49 APE9-dihe-na -89.22, -153.74 APE8-dihe-in -92.85, 123.83 APE8-rot-in 304.19 APE67-dihe-in -63.31, -10.32 -62.77, -45.27 APE12-dist-in 9.5688 APE11-dist-in 8.4688 APE10-dist-in 5.5301 APE9-dist-in 3.7526 None None None XRAY 2.04 0.202 0.226 A 294.0 273.0 0 26 26 0 [[38, 290]] 1.0 4xh6 CAMK_PIM1_HUMAN CAMK 3.2e-65 225.9 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PLK4 PLK4_HUMAN 4JXFA O00444 4 267 970.0 631:301 Type1 Inactive DFGin 5.7745 13.791 None -95.55, -28.87 -121.14, 110.52 -136.15, 55.1 41.08, 91.01 69.3, 11.21 out-out out 11.6408 Saltbr-out 8.5517 HRD-out 45.86, -148.81 -144.85, 178.66 out-out-none SNCoon out-none ActLoopNT-out 14.0667 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.255 0.268 A 266.0 235.0 29 28 12 16 [[12, 265]] 1.0 4jxf CAMK_PLK4_HUMAN CAMK 4.1e-82 281.3 1.0 256.0 256.0 153 154 155 157 159 41 60 64 133 135 134 136.0 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN 4YURA O00444 5 266 970.0 4J7:1000 Type1 Inactive DFGin 5.388 13.6509 None -131.67, -52.13 -104.4, 50.59 -77.08, 999.0 54.8, 85.2 999.0, 999.0 out-out out 10.8729 Saltbr-out 8.065 HRD-out -81.06, -148.13 -47.97, 147.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.202 0.27 A 278.0 226.0 36 28 2 26 [[12, 265]] 1.0 4yur CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1.0 256.0 256.0 153 154 155 157 159 41 60 64 133 135 134 136.0 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PRKAA1 AAPK1_HUMAN 7JHHA Q13131 22 559 559.0 No_ligand No_ligand Inactive DFGin 4.4083 14.0535 None -72.1, -47.74 -146.41, 153.99 -125.94, -39.52 58.73, 92.29 -80.39, -25.75 out-out out 12.6904 Saltbr-out 12.814 HRD-out -119.19, 87.53 -68.79, -38.46 out-out-out SNCooo out-out ActLoopNT-out 5.2997 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -67.5, -39.69 APE9-dihe-na -65.47, -47.47 APE8-dihe-in -135.51, 108.04 APE8-rot-in 295.83 APE67-dihe-in -65.04, -42.29 -74.22, -38.89 APE12-dist-in 11.9622 APE11-dist-out 17.0132 APE10-dist-out 19.009 APE9-dist-out 12.742 None None None EM 3.92 999.0 999.0 A 484.0 379.0 0 27 27 0 [[27, 279]] 1.0 7jhh CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 7JHGA Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 3.9583 12.3851 None -75.55, -57.95 -128.11, 115.65 -75.63, -58.59 53.99, 94.22 -113.12, -1.21 out-out out 12.413 Saltbr-out 12.2756 HRD-out -118.93, 87.19 -68.87, -35.95 out-out-out SNCooo out-out ActLoopNT-out 5.7547 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.04, -42.27 APE9-dihe-na -68.52, -40.55 APE8-dihe-in -128.24, 81.11 APE8-rot-out 178.77 APE67-dihe-in -67.22, -49.66 -68.38, -37.04 APE12-dist-in 12.5847 APE11-dist-out 17.7613 APE10-dist-out 17.9846 APE9-dist-out 11.2385 None None None EM 3.47 999.0 999.0 A 484.0 380.0 0 27 27 0 [[27, 279]] 1.0 7jhg CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 7M74A Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 4.8105 13.2336 None -76.76, -62.2 -122.49, 107.13 -85.46, -38.34 61.13, 92.05 -117.4, -4.69 out-out out 13.6955 Saltbr-out 11.2388 HRD-out -115.45, 89.03 -69.29, -34.6 out-out-out SNCooo out-out ActLoopNT-out 5.6069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -77.56, -39.26 APE9-dihe-na -72.79, -36.52 APE8-dihe-in -124.27, 83.8 APE8-rot-out 178.33 APE67-dihe-in -73.53, -46.6 -74.47, -34.26 APE12-dist-in 12.8577 APE11-dist-out 17.936 APE10-dist-out 18.1451 APE9-dist-out 11.1081 None None None EM 3.93 999.0 999.0 A 484.0 380.0 0 27 27 0 [[27, 279]] 1.0 7m74 CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4RERA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.7243 14.6822 None -104.41, -74.44 -70.58, 123.21 -111.45, 7.12 271.34, 95.59 -64.34, -25.66 in-in in 9.3938 Saltbr-in 3.1678 HRD-out -106.73, 104.09 -76.93, -37.65 in-in-in SNCiii in-in ActLoopNT-in 2.9275 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.23, 162.43 APE9-dihe-na 109.76, -176.61 APE8-dihe-in -65.38, 159.16 APE8-rot-in 282.67 APE67-dihe-in -82.84, -28.7 -67.98, -40.26 APE12-dist-in 8.7645 APE11-dist-in 11.1018 APE10-dist-in 5.3529 APE9-dist-in 4.5655 E480G,E483A,K485A TPO183 TPO183 XRAY 4.047 0.227 0.26 A 540.0 459.0 0 27 27 0 [[27, 279]] 1.0 4rer CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REWA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.2816 14.4447 None -106.98, -78.3 -79.98, 116.66 -98.66, 4.74 266.69, 106.69 -52.57, -49.44 out-out out 10.8944 Saltbr-out 4.8489 HRD-out -91.4, 104.28 -79.59, -35.51 out-in-out SNCoio in-out ActLoopNT-in 2.9485 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -146.3, 177.71 APE9-dihe-na 92.22, 179.97 APE8-dihe-in -62.77, 176.84 APE8-rot-in 309.53 APE67-dihe-in -79.73, -37.36 -85.43, -26.86 APE12-dist-in 9.0318 APE11-dist-in 10.9116 APE10-dist-in 6.0735 APE9-dist-out 7.1663 E480G,E483A,K485A None None XRAY 4.58 0.234 0.259 A 540.0 411.0 0 27 27 0 [[27, 279]] 1.0 4rew CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 7MYJC P54646 8 551 552.0 4O7:601 Type1 Inactive DFGin 7.3145 14.0838 None -132.52, -55.68 -74.88, 101.59 -98.84, 25.6 284.87, 89.61 -69.31, -43.09 out-in out 10.1906 Saltbr-in 3.2112 HRD-in -59.12, -60.67 79.22, -0.71 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.77, 22.41 APE9-dihe-na -62.18, -179.97 APE8-dihe-in -59.88, 136.16 APE8-rot-in 296.22 APE67-dihe-in -61.7, -38.21 -62.19, -37.1 APE12-dist-in 8.6761 APE11-dist-out 7.9979 APE10-dist-out 8.1101 APE9-dist-in 4.3745 None TPO172 TPO172 XRAY 2.95 0.215 0.243 C 565.0 465.0 0 27 27 0 [[16, 268]] 1.0 7myj CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVA P54646 8 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.2674 14.6333 None -121.03, -63.06 -68.65, 101.9 -100.19, 25.35 279.34, 91.81 -68.17, -44.69 in-in in 9.8608 Saltbr-in 2.6899 HRD-in -59.46, -47.11 63.8, -4.14 in-in-in SNCiii in-in ActLoopNT-in 3.0028 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.63, 144.51 APE9-dihe-na 86.66, 177.12 APE8-dihe-in -64.88, 140.75 APE8-rot-in 312.82 APE67-dihe-in -66.61, -22.38 -58.4, -32.39 APE12-dist-in 7.7539 APE11-dist-in 10.4368 APE10-dist-in 5.1306 APE9-dist-in 4.4026 None TPO172 TPO172 XRAY 2.99 0.225 0.245 A 560.0 433.0 0 27 27 0 [[16, 268]] 1.0 5ezv CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVC P54646 9 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.4323 14.3494 None -121.9, -67.2 -69.32, 103.91 -104.03, 30.29 280.2, 90.51 -70.5, -44.85 out-in out 10.4146 Saltbr-in 3.2079 HRD-in -65.9, -50.28 64.78, -4.1 in-in-out SNCiio in-out ActLoopNT-in 2.9393 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.83, 151.12 APE9-dihe-na 88.46, 177.26 APE8-dihe-in -64.21, 140.09 APE8-rot-out 194.68 APE67-dihe-in -65.12, -32.21 -57.93, -31.87 APE12-dist-in 7.8362 APE11-dist-in 10.5358 APE10-dist-in 5.1127 APE9-dist-in 4.4856 None TPO172 TPO172 XRAY 2.99 0.225 0.245 C 560.0 434.0 0 27 27 0 [[16, 268]] 1.0 5ezv CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4ZHXC P54646 9 551 552.0 4O7:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.1494 14.357 None -118.59, -65.8 -66.91, 99.09 -101.33, 23.32 277.19, 90.56 -65.31, -32.83 out-out out 10.3303 Saltbr-out 4.842 HRD-out -73.9, 101.83 -92.2, 22.13 out-in-out SNCoio in-out ActLoopNT-in 2.9999 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -139.02, 115.25 APE9-dihe-na 47.21, -160.8 APE8-dihe-out 29.45, 76.85 APE8-rot-in 332.18 APE67-dihe-in -70.92, -30.7 -62.41, -34.95 APE12-dist-in 7.9051 APE11-dist-in 10.9947 APE10-dist-in 5.5352 APE9-dist-out 6.3235 None TPO172 TPO172 XRAY 2.99 0.226 0.243 C 565.0 453.0 0 27 27 0 [[16, 268]] 1.0 4zhx CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UA P54646 8 550 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.2691 14.4408 None -129.47, -55.38 -79.75, 100.47 -94.16, 25.18 281.88, 87.91 -69.36, -38.1 out-in out 10.0903 Saltbr-in 2.8061 HRD-in -70.7, -48.35 62.09, 8.12 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.71, 141.45 APE9-dihe-na 98.59, 173.56 APE8-dihe-in -72.38, 142.58 APE8-rot-out 181.03 APE67-dihe-in -62.9, -27.33 -58.67, -32.16 APE12-dist-in 7.9718 APE11-dist-in 10.5218 APE10-dist-in 4.9765 APE9-dist-in 3.8757 None TPO172 TPO172 XRAY 2.77 0.196 0.226 A 565.0 442.0 0 27 27 0 [[16, 268]] 1.0 6b1u CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFC P54646 10 551 552.0 STU:61552,C1V:61553 Type1,Allosteric Inactive DFGin 6.7813 14.0798 None -150.62, -172.52 53.67, 68.27 -65.24, -76.3 281.99, 78.69 54.48, -69.27 out-out out 10.8955 Saltbr-out 5.3095 HRD-out -84.81, 105.73 -92.0, 12.06 out-in-out SNCoio in-out ActLoopNT-in 3.0342 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -122.19, 170.3 APE9-dihe-na 112.32, 178.27 APE8-dihe-in -67.95, 156.54 APE8-rot-out 180.36 APE67-dihe-out -82.42, 177.62 -55.27, -42.84 APE12-dist-in 7.7542 APE11-dist-in 11.1374 APE10-dist-in 5.4326 APE9-dist-in 3.967 None TPO172 TPO172 XRAY 3.924 0.211 0.264 C 571.0 423.0 0 27 27 0 [[16, 268]] 1.0 4cff CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK STK11 STK11_HUMAN 8VSUC Q15831 41 347 433.0 No_ligand No_ligand Inactive DFGin 6.4464 14.5042 None -110.4, -67.17 -83.35, 83.69 -74.95, 5.93 266.62, 73.52 -67.08, -28.88 in-in in 9.5869 Saltbr-in 2.8954 HRD-out -94.66, 95.31 -74.45, 3.43 in-in-in SNCiii in-in ActLoopNT-in 2.8361 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.67, 165.4 APE9-dihe-na 90.11, -175.94 APE8-dihe-in -66.66, 120.5 APE8-rot-in 303.23 APE67-dihe-in -69.02, -14.26 -53.47, -39.98 APE12-dist-in 9.6719 APE11-dist-in 11.3659 APE10-dist-in 5.6526 APE9-dist-in 4.1409 None None None EM 2.86 999.0 999.0 C 449.0 307.0 0 30 30 0 [[49, 309]] 1.0 8vsu CAMK_STK11_HUMAN CAMK 9.8e-67 231.0 1.0 256.0 256.0 193 194 195 197 199 78 98 102 173 175 174 176.0 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CK1 VRK1 VRK1_HUMAN 2KTYA Q99986 1 360 396.0 No_ligand No_ligand Inactive DFGin 5.3243 15.1527 None -89.4, 48.25 -88.38, 13.56 -67.73, -15.51 318.79, 139.99 -118.73, -3.9 in-out in 9.5884 Saltbr-out 4.6509 HRD-out -78.42, 104.69 -109.22, 23.05 out-in-out SNCoio in-out ActLoopNT-in 3.1507 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -48.81, -30.88 APE9-dihe-na -140.12, -137.46 APE8-dihe-in -89.92, 130.62 APE8-rot-out 194.46 APE67-dihe-in -50.66, -57.74 -50.93, -21.33 APE12-dist-in 10.4757 APE11-dist-in 11.3557 APE10-dist-in 5.7463 APE9-dist-out 7.4012 None None None NMR 999.0 999.0 999.0 A 368.0 360.0 0 35 35 0 [[37, 326]] 1.0 2kty CK1_VRK1_HUMAN CK1 9.8e-106 358.9 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 2KULA Q99986 1 360 396.0 No_ligand No_ligand Inactive DFGin 6.2491 13.1589 None -136.39, -155.46 72.24, -78.37 55.92, -7.95 293.82, 125.62 -72.72, -31.43 in-in in 8.5828 Saltbr-in 2.6169 HRD-out -119.9, 103.12 -73.71, -46.93 in-in-out SNCiio in-out ActLoopNT-in 2.7684 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -76.69, -64.74 APE9-dihe-na -109.51, -104.17 APE8-dihe-in -89.82, 146.99 APE8-rot-out 38.36 APE67-dihe-in -74.0, -55.74 -68.22, -27.75 APE12-dist-in 10.5392 APE11-dist-in 9.9102 APE10-dist-in 4.082 APE9-dist-out 6.8565 None None None NMR 999.0 999.0 999.0 A 368.0 360.0 0 35 35 0 [[37, 326]] 1.0 2kul CK1_VRK1_HUMAN CK1 9.8e-106 358.9 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CMGC CDK12 CDK12_HUMAN 8BUGH Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 6.8959 15.5984 None -126.85, -81.65 -69.29, 99.31 -95.06, 17.81 283.55, 80.77 -62.15, -37.73 in-out in 8.4976 Saltbr-out 4.2388 HRD-in -64.31, -53.09 70.58, 6.39 out-in-out SNCoio in-out ActLoopNT-in 3.0823 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.05, -49.38 APE9-dihe-na -69.37, 152.54 APE8-dihe-in -59.34, 145.1 APE8-rot-out 62.3 APE67-dihe-in -62.01, -33.03 -53.97, -44.11 APE12-dist-in 12.9733 APE11-dist-in 12.4826 APE10-dist-in 6.5883 APE9-dist-in 3.6522 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1B Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.8884 15.2984 None -128.47, -62.59 -80.73, 98.22 -97.65, 30.1 286.08, 74.34 -69.36, -27.39 in-in in 7.8207 Saltbr-in 3.2637 HRD-in -79.79, -51.42 72.8, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.7133 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.4, -55.58 APE9-dihe-na -85.22, 150.62 APE8-dihe-in -62.26, 144.21 APE8-rot-out 179.44 APE67-dihe-in -65.72, -30.15 -51.5, -38.4 APE12-dist-in 13.2818 APE11-dist-in 11.6162 APE10-dist-in 6.9008 APE9-dist-in 3.7142 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 B 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.9866 15.4035 None -124.14, -66.45 -82.78, 98.54 -96.09, 28.76 284.79, 71.99 -70.28, -26.46 in-in in 7.8662 Saltbr-in 3.166 HRD-in -79.63, -53.16 73.52, -1.03 in-in-out SNCiio in-out ActLoopNT-in 2.7593 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.57, -50.83 APE9-dihe-na -86.52, 154.66 APE8-dihe-in -59.58, 143.86 APE8-rot-out 8.75 APE67-dihe-in -65.52, -30.46 -51.58, -39.94 APE12-dist-in 13.8095 APE11-dist-in 12.2137 APE10-dist-in 7.2362 APE9-dist-in 3.5954 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU2B Q9NYV4 715 1041 1490.0 RVQ:61101 Type1 Inactive DFGin 6.9805 15.316 None -126.39, -67.8 -89.47, 99.61 -92.58, 32.18 287.62, 78.29 -74.11, -9.98 in-in in 7.7621 Saltbr-in 3.4941 HRD-in -72.7, -49.44 72.16, 4.81 in-in-in SNCiii in-in ActLoopNT-in 2.9597 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.12, -45.69 APE9-dihe-na -96.32, 148.59 APE8-dihe-in -57.39, 143.59 APE8-rot-in 288.86 APE67-dihe-in -63.0, -36.42 -47.95, -40.21 APE12-dist-in 13.5359 APE11-dist-in 11.7305 APE10-dist-in 7.073 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bu2 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU3B Q9NYV4 715 1040 1490.0 RSI:1101 Type1 Inactive DFGin 6.8486 15.3593 None -135.97, -63.81 -78.62, 93.23 -91.89, 22.93 285.59, 76.13 -60.89, -23.4 in-in in 7.9934 Saltbr-in 2.817 HRD-in -67.65, -55.64 77.98, -1.58 in-in-in SNCiii in-in ActLoopNT-in 3.0522 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.96, -44.7 APE9-dihe-na -101.31, 148.75 APE8-dihe-in -59.73, 145.03 APE8-rot-in 305.94 APE67-dihe-in -60.6, -36.33 -55.27, -39.92 APE12-dist-in 13.312 APE11-dist-in 11.5417 APE10-dist-in 7.0493 APE9-dist-in 3.3827 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU3H Q9NYV4 715 1044 1490.0 RSI:1101 Type1 Inactive DFGin 6.9756 15.4654 None -130.35, -57.76 -91.85, 92.73 -91.21, 19.54 285.51, 78.88 -63.9, -27.23 in-in in 8.132 Saltbr-in 3.2809 HRD-in -66.37, -58.1 77.05, -1.53 in-in-out SNCiio in-out ActLoopNT-in 3.0176 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.62, -44.32 APE9-dihe-na -91.3, 148.63 APE8-dihe-in -63.87, 147.34 APE8-rot-out 172.41 APE67-dihe-in -60.12, -36.58 -54.35, -41.92 APE12-dist-in 13.7142 APE11-dist-in 11.8523 APE10-dist-in 6.8179 APE9-dist-in 3.3613 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.9424 15.1221 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.3713 Saltbr-out 3.6222 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.7589 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.1246 APE11-dist-in 12.1682 APE10-dist-in 7.2856 APE9-dist-in 3.7263 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU6B Q9NYV4 715 1039 1490.0 RQE:61101 Type1 Inactive DFGin 6.9772 15.0095 None -127.82, -64.26 -87.77, 91.87 -89.24, 20.45 288.89, 72.08 -65.57, -40.39 in-in in 8.424 Saltbr-in 3.4813 HRD-in -70.61, -57.84 77.83, -2.42 in-in-out SNCiio in-out ActLoopNT-in 3.1224 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.14, -54.56 APE9-dihe-na -81.61, 149.37 APE8-dihe-in -53.79, 145.32 APE8-rot-out 74.18 APE67-dihe-in -56.42, -37.71 -55.03, -39.62 APE12-dist-in 13.9274 APE11-dist-in 11.7836 APE10-dist-in 6.969 APE9-dist-in 3.408 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU6H Q9NYV4 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.8592 15.2278 None -123.73, -80.29 -80.87, 99.66 -87.02, 20.65 285.61, 58.62 -65.39, -44.16 in-out in 8.4216 Saltbr-out 5.0958 HRD-in -73.68, -57.19 78.4, -0.7 out-in-out SNCoio in-out ActLoopNT-in 3.0861 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.54, -53.3 APE9-dihe-na -74.55, 153.16 APE8-dihe-in -53.11, 139.67 APE8-rot-out 166.86 APE67-dihe-in -53.97, -35.01 -57.57, -41.34 APE12-dist-in 13.1365 APE11-dist-in 12.4283 APE10-dist-in 7.0199 APE9-dist-in 3.4215 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.8954 15.5504 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.0334 Saltbr-in 3.4619 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.0383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.2624 APE11-dist-in 11.7849 APE10-dist-in 6.4997 APE9-dist-in 3.5775 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUBH Q9NYV4 715 1044 1490.0 RNU:61102 Type1 Inactive DFGin 7.2638 15.677 None -126.03, -25.89 -87.61, 72.88 -91.51, 12.82 280.63, 73.67 -60.75, -39.82 in-in in 8.4819 Saltbr-in 3.5525 HRD-out -79.78, 93.25 -67.97, -38.17 in-out-out SNCioo out-out ActLoopNT-out 3.72 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -109.56, -9.94 APE9-dihe-na -106.55, 22.31 APE8-dihe-out 64.82, 23.4 APE8-rot-out 71.99 APE67-dihe-out -104.68, -30.69 71.46, -1.72 APE12-dist-in 12.7113 APE11-dist-in 12.093 APE10-dist-in 6.8605 APE9-dist-in 4.5978 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUCH Q9NYV4 715 1044 1490.0 RKO:61101 Type1 Inactive DFGin 6.938 15.2425 None -126.85, -64.01 -88.43, 98.06 -96.23, 24.88 287.21, 69.27 -75.34, -9.66 in-in in 7.9464 Saltbr-in 3.3005 HRD-in -84.47, -51.91 75.61, -7.74 in-in-in SNCiii in-in ActLoopNT-in 2.9789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, -52.72 APE9-dihe-na -81.82, 150.47 APE8-dihe-in -58.85, 136.79 APE8-rot-in 300.83 APE67-dihe-in -60.33, -38.14 -49.32, -40.23 APE12-dist-in 13.7625 APE11-dist-in 11.7819 APE10-dist-in 6.9727 APE9-dist-in 3.2597 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUEB Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.8762 15.6 None -134.01, -59.19 -81.95, 94.22 -92.57, 38.59 286.02, 76.0 -80.72, -24.77 in-in in 7.932 Saltbr-in 2.9874 HRD-in -72.56, -56.91 77.87, 2.52 in-in-out SNCiio in-out ActLoopNT-in 2.9042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.91, -27.24 APE9-dihe-na -111.61, 155.18 APE8-dihe-in -59.11, 144.49 APE8-rot-out 174.63 APE67-dihe-in -64.14, -33.78 -56.66, -36.69 APE12-dist-in 13.2286 APE11-dist-in 11.5753 APE10-dist-in 6.8399 APE9-dist-in 3.7328 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUFB Q9NYV4 715 1033 1490.0 RW6:61101 Type1 Inactive DFGin 6.9051 15.6357 None -129.93, -62.21 -79.23, 97.53 -95.7, 37.47 286.05, 76.01 -76.9, -21.74 in-in in 8.1053 Saltbr-in 3.1532 HRD-in -72.11, -52.31 75.51, 2.58 in-in-out SNCiio in-out ActLoopNT-in 2.8864 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.68, -63.24 APE9-dihe-na -77.98, 146.57 APE8-dihe-in -61.93, 149.44 APE8-rot-out 186.78 APE67-dihe-in -61.63, -31.53 -53.67, -39.8 APE12-dist-in 13.1702 APE11-dist-in 10.9939 APE10-dist-in 6.5903 APE9-dist-in 3.5503 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 B 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8buf CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUFH Q9NYV4 715 1032 1490.0 RW6:61101 Type1 Inactive DFGin 7.1171 15.5053 None -129.62, -58.72 -84.56, 91.07 -93.16, 33.34 286.36, 76.3 -77.96, -20.03 in-out in 8.1468 Saltbr-out 3.7328 HRD-in -74.59, -54.27 72.47, 1.47 out-in-in SNCoii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.36, -62.78 APE9-dihe-na -81.18, 153.72 APE8-dihe-in -60.4, 148.16 APE8-rot-in 306.45 APE67-dihe-in -63.34, -32.17 -56.22, -41.31 APE12-dist-in 13.7169 APE11-dist-in 11.792 APE10-dist-in 7.061 APE9-dist-in 3.3785 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 H 344.0 318.0 0 29 29 0 [[727, 1020]] 1.0 8buf CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUGB Q9NYV4 715 1041 1490.0 RPW:61101 Type1 Inactive DFGin 6.885 15.532 None -132.35, -51.84 -89.28, 88.82 -91.59, 19.28 282.49, 80.64 -62.07, -38.03 in-in in 8.0337 Saltbr-in 2.912 HRD-in -62.84, -54.31 70.37, 7.41 in-in-out SNCiio in-out ActLoopNT-in 3.0011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -68.25, -47.63 APE9-dihe-na -75.15, 151.02 APE8-dihe-in -63.11, 148.71 APE8-rot-out 182.54 APE67-dihe-in -62.59, -33.17 -53.62, -43.42 APE12-dist-in 12.5031 APE11-dist-in 11.8127 APE10-dist-in 6.379 APE9-dist-in 3.619 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUHB Q9NYV4 715 1039 1490.0 RR9:61101 Type1 Inactive DFGin 7.1787 15.539 None -138.13, -51.2 -84.38, 89.05 -94.33, 22.38 291.72, 70.83 -65.07, -27.18 in-in in 8.1562 Saltbr-in 3.1703 HRD-in -65.3, -52.38 69.31, 6.78 in-in-out SNCiio in-out ActLoopNT-in 2.9184 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.08, -42.42 APE9-dihe-na -75.03, 155.7 APE8-dihe-in -68.77, 151.86 APE8-rot-out 184.25 APE67-dihe-in -61.51, -37.69 -56.24, -40.88 APE12-dist-in 12.2995 APE11-dist-in 11.9854 APE10-dist-in 6.1967 APE9-dist-in 3.6729 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8buh CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUHH Q9NYV4 715 1033 1490.0 RR9:61101 Type1 Inactive DFGin 6.8874 15.2204 None -138.17, -50.63 -86.02, 83.59 -88.15, 19.63 292.55, 71.89 -63.06, -22.61 in-in in 8.184 Saltbr-in 2.9431 HRD-in -66.24, -47.16 69.47, -1.27 in-in-out SNCiio in-out ActLoopNT-in 3.0446 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.8, -40.23 APE9-dihe-na -75.94, 158.01 APE8-dihe-in -67.45, 146.95 APE8-rot-out 179.42 APE67-dihe-in -59.63, -39.48 -58.91, -41.72 APE12-dist-in 13.2298 APE11-dist-in 12.4677 APE10-dist-in 6.767 APE9-dist-in 3.3762 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 H 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8buh CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUJB Q9NYV4 715 1041 1490.0 RUW:1101 Type1 Inactive DFGin 6.983 15.1999 None -129.99, -57.9 -94.94, 86.34 -84.73, 29.33 287.08, 75.1 -66.06, -25.85 in-in in 7.8642 Saltbr-in 2.9459 HRD-in -63.86, -54.33 75.41, -2.11 in-in-out SNCiio in-out ActLoopNT-in 3.0628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -117.09, -50.74 APE9-dihe-na -90.83, 154.53 APE8-dihe-in -64.5, 148.14 APE8-rot-out 189.98 APE67-dihe-in -60.8, -34.01 -57.18, -38.53 APE12-dist-in 13.2622 APE11-dist-in 11.4247 APE10-dist-in 7.1058 APE9-dist-in 3.5216 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8buj CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUJH Q9NYV4 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 6.896 15.0772 None -125.46, -61.45 -96.84, 87.36 -85.01, 26.05 287.54, 74.01 -66.36, -25.41 in-in in 7.8133 Saltbr-in 3.0099 HRD-in -63.78, -55.47 74.76, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.9668 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.8, -48.82 APE9-dihe-na -90.4, 155.44 APE8-dihe-in -63.14, 147.75 APE8-rot-in 306.89 APE67-dihe-in -59.19, -33.71 -59.17, -40.93 APE12-dist-in 13.546 APE11-dist-in 11.4373 APE10-dist-in 6.9005 APE9-dist-in 3.4536 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8buj CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUKB Q9NYV4 715 1040 1490.0 RWE:61101 Type1 Inactive DFGin 6.8676 15.185 None -136.79, -63.9 -86.16, 95.92 -96.18, 34.75 292.05, 70.82 -73.05, -21.93 in-in in 7.9967 Saltbr-in 2.8964 HRD-in -70.18, -56.12 75.44, 6.36 in-in-in SNCiii in-in ActLoopNT-in 2.9507 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.1, -51.8 APE9-dihe-na -97.16, 156.72 APE8-dihe-in -60.0, 144.72 APE8-rot-in 296.0 APE67-dihe-in -62.91, -30.64 -55.4, -37.75 APE12-dist-in 13.3442 APE11-dist-in 11.4945 APE10-dist-in 7.2213 APE9-dist-in 3.6338 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buk CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUKH Q9NYV4 715 1044 1490.0 RWE:61101 Type1 Inactive DFGin 6.839 15.2471 None -132.41, -70.3 -85.48, 98.43 -94.85, 32.62 289.18, 70.32 -75.66, -23.83 in-in in 8.0838 Saltbr-in 3.0875 HRD-in -67.86, -57.14 74.14, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.8859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.71, -45.22 APE9-dihe-na -97.3, 156.39 APE8-dihe-in -62.45, 146.81 APE8-rot-out 169.98 APE67-dihe-in -63.55, -31.48 -56.16, -39.65 APE12-dist-in 13.6893 APE11-dist-in 11.7966 APE10-dist-in 7.1304 APE9-dist-in 3.7281 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buk CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BULB Q9NYV4 715 1039 1490.0 RSU:1101 Type1 Inactive DFGin 7.0478 15.5723 None -134.15, -61.62 -82.15, 93.36 -91.03, 19.31 284.15, 82.25 -57.36, -30.14 in-in in 7.9382 Saltbr-in 2.9293 HRD-in -70.64, -53.34 75.97, 4.36 in-in-in SNCiii in-in ActLoopNT-in 3.1167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.1, -23.33 APE9-dihe-na -106.91, 152.49 APE8-dihe-in -59.59, 141.04 APE8-rot-in 301.22 APE67-dihe-in -61.09, -37.16 -52.97, -42.84 APE12-dist-in 13.2976 APE11-dist-in 11.6069 APE10-dist-in 6.723 APE9-dist-in 3.6083 None TPO893 TPO893 XRAY 3.4 0.179 0.215 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMB Q9NYV4 715 1040 1490.0 T6X:1101 Type1 Inactive DFGin 6.8637 15.6654 None -134.73, -83.5 -67.29, 93.27 -90.11, 26.53 284.48, 75.06 -65.26, -28.59 in-in in 7.994 Saltbr-in 3.4847 HRD-in -65.89, -56.24 77.66, 6.87 in-in-in SNCiii in-in ActLoopNT-in 3.1268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, -38.62 APE9-dihe-na -95.11, 154.79 APE8-dihe-in -60.97, 148.11 APE8-rot-in 309.8 APE67-dihe-in -61.69, -36.7 -58.55, -38.83 APE12-dist-in 13.4563 APE11-dist-in 11.5984 APE10-dist-in 6.6698 APE9-dist-in 3.6672 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMH Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Inactive DFGin 7.0235 15.4568 None -135.37, -57.05 -84.79, 89.46 -91.01, 22.09 287.95, 72.46 -66.77, -30.21 in-out in 8.0681 Saltbr-out 4.1308 HRD-in -66.21, -56.87 75.95, 5.67 out-in-in SNCoii in-in ActLoopNT-in 2.9548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.45, -40.59 APE9-dihe-na -95.46, 155.5 APE8-dihe-in -61.11, 150.0 APE8-rot-in 312.75 APE67-dihe-in -61.06, -36.71 -56.48, -41.62 APE12-dist-in 13.6249 APE11-dist-in 11.7363 APE10-dist-in 7.1678 APE9-dist-in 3.5793 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUOH Q9NYV4 715 1044 1490.0 RLC:1101 Type1 Inactive DFGin 6.9531 15.2665 None -133.0, -52.84 -89.06, 92.6 -92.03, 19.54 286.01, 76.31 -65.14, -29.67 in-in in 8.1958 Saltbr-in 3.2893 HRD-in -68.8, -55.72 77.31, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.5, -30.39 APE9-dihe-na -96.1, 151.94 APE8-dihe-in -61.51, 140.45 APE8-rot-in 333.9 APE67-dihe-in -58.03, -34.02 -53.9, -41.38 APE12-dist-in 13.5492 APE11-dist-in 11.7907 APE10-dist-in 6.7655 APE9-dist-in 3.3578 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUQH Q9NYV4 715 1035 1490.0 RQ9:61101 Type1 Inactive DFGin 6.8471 15.4131 None -139.0, -68.9 -74.65, 86.14 -87.77, 25.62 285.6, 75.05 -68.98, -27.88 in-in in 8.1409 Saltbr-in 3.3418 HRD-in -71.56, -55.82 75.32, -0.25 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.77, -46.85 APE9-dihe-na -88.37, 155.15 APE8-dihe-in -63.62, 147.91 APE8-rot-out 74.55 APE67-dihe-in -59.91, -28.34 -56.29, -43.5 APE12-dist-in 13.7059 APE11-dist-in 11.9801 APE10-dist-in 7.0593 APE9-dist-in 3.5434 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 H 344.0 321.0 0 29 29 0 [[727, 1020]] 1.0 8buq CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BURH Q9NYV4 715 1039 1490.0 RQU:61101 Type1 Inactive DFGin 6.7739 15.4438 None -128.98, -68.65 -83.3, 94.14 -94.27, 19.71 289.32, 85.87 -66.64, -31.92 in-in in 8.1448 Saltbr-in 2.8791 HRD-in -62.95, -51.76 69.51, 6.54 in-in-out SNCiio in-out ActLoopNT-in 3.108 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.35, -54.64 APE9-dihe-na -87.35, 151.65 APE8-dihe-in -60.57, 144.24 APE8-rot-out 76.95 APE67-dihe-in -62.32, -33.37 -50.2, -40.95 APE12-dist-in 13.7432 APE11-dist-in 11.6616 APE10-dist-in 7.0858 APE9-dist-in 3.6711 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bur CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUSE Q9NYV4 715 1043 1490.0 RMX:1101 Type1 Inactive DFGin 6.7257 15.8693 None -132.84, -50.43 -84.41, 82.25 -87.45, 22.35 281.7, 77.83 -63.73, -33.79 in-in in 8.1583 Saltbr-in 3.2823 HRD-in -70.71, -48.94 71.36, 12.53 in-in-out SNCiio in-out ActLoopNT-in 2.9956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.11, -47.21 APE9-dihe-na -97.32, 150.19 APE8-dihe-in -67.32, 151.1 APE8-rot-out 195.8 APE67-dihe-in -58.67, -27.66 -56.54, -42.34 APE12-dist-in 13.2846 APE11-dist-in 11.3926 APE10-dist-in 7.3398 APE9-dist-in 3.4564 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bus CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.1242 15.0312 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.3316 Saltbr-out 4.4499 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.0722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.9874 APE11-dist-in 12.2701 APE10-dist-in 7.331 APE9-dist-in 3.8645 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351.0 334.0 0 29 29 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 8BYAA P24941 16 296 298.0 No_ligand No_ligand Inactive DFGin 6.9616 16.2924 None -134.63, 82.03 -161.61, 106.37 -138.09, 26.66 284.26, 105.76 -68.14, -60.43 out-none out 10.0623 Saltbr-none 999.0 HRD-out -108.07, -22.97 56.97, -114.32 none-out-out SNCnoo out-out ActLoopNT-out 4.3007 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -82.31, 123.39 APE9-dihe-na -125.74, 132.38 APE8-dihe-in -58.14, 137.63 APE8-rot-in 294.3 APE67-dihe-in -69.0, -10.69 -52.48, -40.96 APE12-dist-in 11.3246 APE11-dist-out 6.4466 APE10-dist-out 9.1399 APE9-dist-out 7.1292 None TPO159 TPO159 EM 3.38 999.0 999.0 A 298.0 277.0 16 28 28 0 [[4, 286]] 1.0 8bya CMGC_CDK2_HUMAN CMGC 6.1e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5UQ1C P24941 1 289 298.0 No_ligand No_ligand Inactive DFGin 6.5957 15.6532 None -143.1, 67.57 -125.34, 19.31 -94.36, 26.08 301.42, 106.66 -81.71, -31.95 in-in in 9.2997 Saltbr-in 3.187 HRD-in -81.67, -52.04 53.83, 40.34 in-in-out SNCiio in-out ActLoopNT-in 2.7825 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -139.61, -123.49 APE9-dihe-na -60.35, 138.62 APE8-dihe-in -67.73, 105.22 APE8-rot-out 72.15 APE67-dihe-out -22.19, -25.42 16.7, -96.86 APE12-dist-in 12.2985 APE11-dist-in 8.652 APE10-dist-in 7.5404 APE9-dist-in 3.9452 None None None XRAY 3.201 0.208 0.261 C 301.0 289.0 0 28 28 0 [[4, 286]] 1.0 5uq1 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5OO1A P24941 4 298 298.0 9Z2:301 Type1 Inactive DFGin 7.6369 16.0223 None -121.17, 166.43 66.4, 43.63 -62.57, 999.0 279.44, 78.94 999.0, 999.0 out-out out 15.4399 Saltbr-out 10.7818 HRD-in -81.97, -55.23 75.2, -10.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.58 APE8-dihe-out -76.46, -29.98 APE8-rot-in 295.35 APE67-dihe-in -58.08, -20.66 -40.64, -49.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1659 F80C,C177A None None XRAY 2.0 0.187 0.236 A 303.0 278.0 17 28 11 17 [[4, 286]] 1.0 5oo1 CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1PYEA P24941 1 298 298.0 PM1:700 Type1 Inactive DFGin 8.2202 15.4649 None -124.58, 165.75 48.02, 64.22 -62.08, 999.0 279.52, 59.87 999.0, 999.0 out-out out 15.012 Saltbr-out 12.4597 HRD-in -83.61, -50.44 78.62, -18.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 167.42 APE9-dihe-na -72.88, 127.15 APE8-dihe-in -72.71, 140.05 APE8-rot-out 63.06 APE67-dihe-in -52.66, -26.74 -106.34, -2.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5475 None None None XRAY 2.0 0.239 0.252 A 298.0 266.0 32 28 12 16 [[4, 286]] 1.0 1pye CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2W05A P24941 1 298 298.0 FRT:1299 Type1 Inactive DFGin 8.9053 15.9289 None -128.23, 165.06 62.24, 43.64 -62.21, -101.33 274.85, 83.58 96.54, -134.12 out-out out 15.0109 Saltbr-out 13.5797 HRD-in -86.31, -48.92 76.7, -14.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.95, 27.61 APE9-dihe-na -84.15, 133.89 APE8-dihe-in -68.78, 136.67 APE8-rot-out 189.07 APE67-dihe-in -51.29, -28.78 -104.64, -0.82 APE12-dist-none 999.0 APE11-dist-out 16.5822 APE10-dist-out 19.1827 APE9-dist-out 10.3722 None None None XRAY 1.9 0.23 0.293 A 298.0 276.0 22 28 15 13 [[4, 286]] 1.0 2w05 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5D1JA P24941 1 298 298.0 56H:4000 Type1 Inactive DFGin 8.6373 15.2838 None -137.97, 170.56 53.49, 55.77 -71.24, 999.0 283.47, 73.89 999.0, 999.0 out-none out 14.9289 Saltbr-none 999.0 HRD-in -80.57, -53.12 79.22, -17.55 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.54 APE8-dihe-in -86.85, 121.49 APE8-rot-in 299.19 APE67-dihe-in -55.62, -31.72 -100.82, -4.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1545 None None None XRAY 1.8 0.203 0.232 A 298.0 265.0 33 28 11 17 [[4, 286]] 1.0 5d1j CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QL8A P24941 1 298 298.0 X01:300 Type1 Inactive DFGin 9.1322 15.4352 None -122.25, 168.91 72.46, -145.11 131.38, -129.83 255.48, 110.66 -62.05, 95.07 out-out out 15.5659 Saltbr-out 15.2062 HRD-in -84.45, -59.47 81.38, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.6087 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -83.89, 109.54 APE9-dihe-na -59.93, 129.67 APE8-dihe-in -81.59, 123.65 APE8-rot-in 299.9 APE67-dihe-in -51.56, -28.22 -100.19, -8.52 APE12-dist-out 19.7188 APE11-dist-out 16.7576 APE10-dist-out 19.0354 APE9-dist-out 11.0608 None None None XRAY 1.9 0.202 0.238 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3ql8 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QWJA P24941 1 298 298.0 X6A:483 Type1 Inactive DFGin 10.8275 18.6046 None -114.29, 146.98 65.6, 42.02 -53.47, -101.22 231.88, 79.31 -68.75, 30.41 out-out out 15.3452 Saltbr-out 12.4266 HRD-in -84.5, -56.26 82.9, -19.63 out-out-out SNCooo out-out ActLoopNT-out 6.1307 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.81, 125.39 APE9-dihe-na -71.61, 131.09 APE8-dihe-in -83.22, 123.55 APE8-rot-in 295.87 APE67-dihe-in -56.8, -26.34 -103.15, 1.31 APE12-dist-out 20.2894 APE11-dist-out 17.6309 APE10-dist-out 19.6755 APE9-dist-out 10.9886 None None None XRAY 1.75 0.206 0.229 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3qwj CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QX4A P24941 1 298 298.0 X4B:454 Type1 Inactive DFGin 10.9876 18.3391 None -117.48, 147.66 64.55, 41.52 -55.77, -90.1 235.01, 81.0 -76.36, 28.96 out-out out 15.6348 Saltbr-out 14.18 HRD-in -81.9, -60.6 86.28, -21.21 out-out-out SNCooo out-out ActLoopNT-out 5.9234 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -65.97, 121.02 APE9-dihe-na -66.55, 127.88 APE8-dihe-in -80.02, 120.64 APE8-rot-in 297.75 APE67-dihe-in -54.34, -28.48 -100.67, -3.24 APE12-dist-out 20.0847 APE11-dist-out 17.4216 APE10-dist-out 19.6901 APE9-dist-out 10.935 None None None XRAY 1.92 0.205 0.238 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3qx4 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3R9HA P24941 1 298 298.0 Z67:606 Type1 Inactive DFGin 8.3031 15.2871 None -120.0, 168.79 77.09, -84.14 71.52, 122.55 279.89, 89.71 -46.26, -69.21 out-out out 14.7757 Saltbr-out 14.153 HRD-in -82.5, -51.28 73.26, -15.2 out-out-out SNCooo out-out ActLoopNT-out 7.8678 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -57.18, 102.97 APE9-dihe-na -66.25, 137.88 APE8-dihe-in -87.27, 136.09 APE8-rot-in 301.21 APE67-dihe-in -49.8, -36.88 -111.15, -2.68 APE12-dist-out 20.7236 APE11-dist-out 17.6738 APE10-dist-out 20.0369 APE9-dist-out 11.0969 None None None XRAY 2.1 0.214 0.259 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3r9h CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RK5A P24941 1 298 298.0 07Z:436 Type1 Inactive DFGin 8.2539 15.1511 None -135.71, 162.54 80.12, -66.74 62.53, 4.94 282.99, 77.39 53.28, -132.52 out-out out 14.7356 Saltbr-out 13.1253 HRD-in -80.28, -56.17 79.56, -17.53 out-out-out SNCooo out-out ActLoopNT-out 7.5753 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.64, 108.95 APE9-dihe-na -69.16, 141.75 APE8-dihe-in -86.76, 130.53 APE8-rot-in 282.62 APE67-dihe-in -51.32, -32.2 -101.03, -6.74 APE12-dist-out 20.0537 APE11-dist-out 16.5631 APE10-dist-out 18.8447 APE9-dist-out 11.0317 None None None XRAY 2.0 0.206 0.238 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3rk5 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RK7A P24941 1 298 298.0 08Z:467 Type1 Inactive DFGin 8.2288 15.1605 None -129.7, 167.95 74.53, -59.76 60.9, 15.2 281.75, 75.35 53.86, -103.4 out-out out 14.8874 Saltbr-out 15.0248 HRD-in -81.84, -56.89 82.92, -16.54 out-out-out SNCooo out-out ActLoopNT-out 7.6756 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.0, 97.8 APE9-dihe-na -61.23, 134.9 APE8-dihe-in -84.34, 129.91 APE8-rot-in 290.25 APE67-dihe-in -55.99, -28.83 -103.41, -0.58 APE12-dist-out 20.8558 APE11-dist-out 17.133 APE10-dist-out 19.5784 APE9-dist-out 11.0607 None None None XRAY 1.8 0.206 0.224 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3rk7 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RKBA P24941 1 298 298.0 12Z:457 Type1 Inactive DFGin 7.9623 15.3438 None -136.32, 169.7 52.72, 57.61 -64.16, -102.19 278.37, 71.06 -78.55, 125.67 out-out out 15.3178 Saltbr-out 13.6224 HRD-in -80.71, -50.21 81.81, -22.27 out-out-out SNCooo out-out ActLoopNT-out 8.9288 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.87, 109.93 APE9-dihe-na -69.0, 132.49 APE8-dihe-in -79.46, 128.25 APE8-rot-out 184.86 APE67-dihe-in -52.12, -32.05 -102.56, -4.29 APE12-dist-out 17.0609 APE11-dist-out 14.0071 APE10-dist-out 16.7881 APE9-dist-out 11.0395 None None None XRAY 2.0 0.207 0.246 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3rkb CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RM6A P24941 1 298 298.0 18Z:478 Type1 Inactive DFGin 8.595 15.4797 None -127.31, 175.21 70.31, -63.24 64.35, 17.5 284.18, 82.41 61.96, 14.33 out-out out 15.7131 Saltbr-out 17.4313 HRD-in -88.48, -59.71 83.31, -19.73 out-out-out SNCooo out-out ActLoopNT-out 6.2573 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.49, 112.67 APE9-dihe-na -67.84, 129.1 APE8-dihe-in -77.92, 125.13 APE8-rot-out 171.09 APE67-dihe-in -52.76, -26.7 -104.02, -2.64 APE12-dist-out 19.2027 APE11-dist-out 15.5976 APE10-dist-out 18.7719 APE9-dist-out 11.1306 None None None XRAY 1.6 0.22 0.241 A 306.0 293.0 5 28 28 0 [[4, 286]] 1.0 3rm6 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3S0OA P24941 1 298 298.0 50Z:446 Type1 Inactive DFGin 8.5043 14.9871 None -136.17, 174.47 56.71, 50.73 -53.6, 999.0 285.42, 58.7 999.0, 999.0 out-out out 15.686 Saltbr-out 14.1408 HRD-in -92.71, -50.76 76.76, -17.93 out-out-out SNCooo out-out ActLoopNT-out 5.7216 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -76.57, 93.08 APE9-dihe-na -52.85, 136.54 APE8-dihe-in -88.54, 130.77 APE8-rot-out 176.51 APE67-dihe-in -49.84, -33.28 -101.8, -5.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0353 None None None XRAY 2.0 0.213 0.271 A 306.0 293.0 5 28 26 2 [[4, 286]] 1.0 3s0o CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8RU8A P24941 1 298 298.0 I74:301 Type1 Inactive DFGin 8.4918 15.3722 None -138.93, 165.19 64.8, 51.39 -61.53, 999.0 281.7, 71.9 999.0, 999.0 out-out out 15.2096 Saltbr-out 14.4068 HRD-in -79.32, -55.83 85.03, -22.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -92.95, 127.12 APE9-dihe-na -56.69, 130.27 APE8-dihe-in -92.47, 122.83 APE8-rot-in 301.98 APE67-dihe-in -63.56, -25.08 -104.73, 1.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2567 I10L,T14Q,V64I,K88E,K89V,D92K,Q131N None None XRAY 1.51 0.205 0.241 A 306.0 275.0 23 28 14 14 [[4, 286]] 1.0 8ru8 CMGC_CDK2_HUMAN CMGC 1.5e-88 303.3 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3EZRA P24941 1 298 298.0 EZR:300,EZR:301 Type1,Allosteric Inactive DFGin 10.1386 18.1306 None -127.03, 166.36 56.16, 26.16 -69.94, 999.0 212.22, 111.94 999.0, 999.0 out-out out 14.9797 Saltbr-out 15.4403 HRD-in -76.59, -53.67 86.14, -23.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.39 APE8-rot-out 187.95 APE67-dihe-in -60.61, -23.99 -102.93, -2.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.208 0.243 A 300.0 273.0 25 28 10 18 [[4, 286]] 1.0 3ezr CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK4 CDK4_HUMAN 6P8EB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 7.0044 13.6286 None -117.77, -72.88 -107.88, 78.51 -118.9, 163.81 54.02, 80.6 48.95, 65.67 out-out out 12.409 Saltbr-out 13.388 HRD-in -64.13, -55.39 86.4, -18.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.05 APE8-rot-out 188.09 APE67-dihe-in -66.03, -29.27 -109.32, 4.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 G43E,G47E None None XRAY 2.3 0.175 0.222 B 302.0 260.0 31 27 12 15 [[6, 295]] 1.0 6p8e CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CMGC CDK4 CDK4_HUMAN 6P8FB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 6.7494 13.7427 None -149.06, 177.93 56.83, 84.9 -168.16, 150.56 57.88, 90.12 60.26, 33.17 out-out out 12.4664 Saltbr-out 11.937 HRD-in -67.53, -46.86 65.41, -6.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 167.16 APE8-dihe-in -108.02, 135.84 APE8-rot-out 185.16 APE67-dihe-in -61.26, -17.97 -103.23, 9.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3291 G43E,G47E None None XRAY 2.89 0.189 0.242 B 302.0 262.0 29 27 14 13 [[6, 295]] 1.0 6p8f CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CMGC CDK4 CDK4_HUMAN 2W9FB P11802 5 295 303.0 No_ligand No_ligand Inactive DFGin 7.1342 12.7862 None -118.14, -62.46 -136.13, 77.76 -93.66, 151.53 25.95, 76.09 57.89, -6.88 out-out out 13.7541 Saltbr-out 16.4265 HRD-in -86.38, -51.14 71.27, -31.56 out-out-none SNCoon out-none ActLoopNT-out 7.2591 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 96.26 APE8-rot-in 295.94 APE67-dihe-in -52.44, -36.01 -70.67, 6.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 G43E,G47E,T172F None None XRAY 2.85 0.229 0.3 B 306.0 261.0 27 27 21 6 [[6, 295]] 1.0 2w9f CMGC_CDK4_HUMAN CMGC 1.5e-82 285.6 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CMGC CDK7 CDK7_HUMAN 1UA2A P50613 13 311 346.0 ATP:381 ATPlike Inactive DFGin 3.8381 15.0736 None -72.36, 176.54 -63.29, 129.93 -58.5, 61.34 34.11, 88.78 62.95, -115.18 out-out out 13.0144 Saltbr-out 13.6332 HRD-out -71.94, 127.86 -111.75, 17.16 out-out-out SNCooo out-out ActLoopNT-out 10.7811 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.17, 155.77 APE9-dihe-na -94.04, -36.01 APE8-dihe-out 80.52, 83.34 APE8-rot-in 310.15 APE67-dihe-in -70.12, 0.07 -111.89, 13.44 APE12-dist-out 21.6082 APE11-dist-out 18.7453 APE10-dist-out 20.4575 APE9-dist-out 13.0189 None TPO170 TPO170 XRAY 3.02 0.217 0.288 A 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2B P50613 13 311 346.0 ATP:382 ATPlike Inactive DFGin 4.0749 14.4826 None -83.42, -165.13 -43.25, 135.34 -79.47, 27.14 49.47, 35.58 128.26, -117.59 out-out out 13.2082 Saltbr-out 11.1817 HRD-out -90.35, 54.77 -58.64, -3.2 out-out-out SNCooo out-out ActLoopNT-out 10.7547 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -59.37, 128.97 APE9-dihe-na -70.17, -103.62 APE8-dihe-out 114.41, 132.59 APE8-rot-out 86.06 APE67-dihe-in -64.71, -6.03 -138.86, 19.47 APE12-dist-out 21.3562 APE11-dist-out 17.9388 APE10-dist-out 20.1165 APE9-dist-out 13.1186 None TPO170 TPO170 XRAY 3.02 0.217 0.288 B 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2C P50613 13 311 346.0 ATP:383 ATPlike Inactive DFGin 4.3773 15.832 None -69.53, 164.86 -53.4, 113.84 -55.09, 81.41 35.63, 74.81 38.07, -90.08 out-out out 14.2914 Saltbr-out 13.3504 HRD-out -90.81, 75.3 -67.23, 24.34 out-out-out SNCooo out-out ActLoopNT-out 10.7246 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.3, 146.02 APE9-dihe-na -103.14, 168.98 APE8-dihe-in -149.98, 115.15 APE8-rot-in 317.59 APE67-dihe-in -70.34, -0.48 -115.08, 9.43 APE12-dist-out 21.9947 APE11-dist-out 19.6363 APE10-dist-out 20.1195 APE9-dist-out 12.6188 None TPO170 TPO170 XRAY 3.02 0.217 0.288 C 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2D P50613 13 311 346.0 ATP:384 ATPlike Inactive DFGin 3.9714 15.4823 None -66.13, 178.54 -66.01, 128.6 -62.88, 66.21 38.44, 67.87 63.18, -97.8 out-out out 13.2417 Saltbr-out 13.5751 HRD-out -80.45, 94.07 -71.75, -5.97 out-out-out SNCooo out-out ActLoopNT-out 10.8955 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.63, 129.76 APE9-dihe-na -71.09, 152.84 APE8-dihe-in -147.91, 130.69 APE8-rot-out 68.98 APE67-dihe-in -88.14, 9.58 -128.15, 23.18 APE12-dist-out 22.1448 APE11-dist-out 18.8445 APE10-dist-out 20.0096 APE9-dist-out 12.6573 None TPO170 TPO170 XRAY 3.02 0.217 0.288 D 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BA P50613 1 311 346.0 ANP:401 ATPlike Inactive DFGin 6.6665 15.0398 None -136.41, -179.13 75.36, -66.57 59.32, 16.33 291.11, 69.78 55.95, 32.69 out-out out 13.486 Saltbr-out 13.7543 HRD-in -65.3, -54.78 73.94, 0.68 out-out-out SNCooo out-out ActLoopNT-out 12.5504 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -74.63, 115.42 APE9-dihe-na -115.54, -2.31 APE8-dihe-out -56.05, -31.84 APE8-rot-out 157.42 APE67-dihe-in -63.34, -23.16 -66.49, -24.29 APE12-dist-out 18.0017 APE11-dist-out 20.1866 APE10-dist-out 16.0858 APE9-dist-out 11.4652 S164D,T170E None None XRAY 2.21 0.195 0.243 A 352.0 301.0 10 28 28 0 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BB P50613 3 310 346.0 ANP:402 ATPlike Inactive DFGin 6.5631 15.0836 None -126.22, 177.01 84.52, -73.28 65.77, 22.93 292.14, 76.04 47.33, 39.02 out-out out 13.6069 Saltbr-out 11.882 HRD-in -71.08, -53.54 74.78, -6.63 out-out-out SNCooo out-out ActLoopNT-out 12.9359 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.04, 115.32 APE9-dihe-na -115.04, 1.93 APE8-dihe-out -60.49, -32.76 APE8-rot-out 168.86 APE67-dihe-in -59.67, -24.77 -68.61, -28.01 APE12-dist-out 17.7792 APE11-dist-out 20.1865 APE10-dist-out 16.1566 APE9-dist-out 11.4157 S164D,T170E None None XRAY 2.21 0.195 0.243 B 352.0 298.0 10 28 28 0 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BC P50613 8 311 346.0 ANP:402 ATPlike Inactive DFGin 6.4512 15.3403 None -116.21, 176.78 77.39, -97.04 64.16, 26.01 311.61, 20.83 46.47, 58.36 out-out out 13.1044 Saltbr-out 12.1328 HRD-in -78.41, -55.45 77.67, -2.52 out-out-out SNCooo out-out ActLoopNT-out 12.9218 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.76 APE9-dihe-na -87.2, -35.35 APE8-dihe-out -49.87, -35.32 APE8-rot-in 271.7 APE67-dihe-in -63.34, -21.13 -58.67, -34.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9279 APE9-dist-out 10.9338 S164D,T170E None None XRAY 2.21 0.195 0.243 C 352.0 276.0 28 28 16 12 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BD P50613 9 311 346.0 ANP:402 ATPlike Inactive DFGin 5.1856 15.5294 None -119.23, -173.72 58.44, -119.7 56.58, 114.74 106.06, 59.9 70.5, -151.21 out-out out 13.0617 Saltbr-out 12.3535 HRD-in -80.52, -56.05 80.67, -8.56 out-out-out SNCooo out-out ActLoopNT-out 13.0554 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -29.49 APE9-dihe-na -113.47, -32.42 APE8-dihe-out -62.11, -27.52 APE8-rot-out 75.68 APE67-dihe-in -62.12, -24.79 -50.05, -35.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.1604 APE9-dist-out 11.1556 S164D,T170E None None XRAY 2.21 0.195 0.243 D 352.0 277.0 26 28 18 10 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9SB P50613 9 312 346.0 PE3:401,PE3:402,YPK:403 Allosteric,Allosteric,Type1 Inactive DFGin 6.6614 14.1368 None -136.72, -83.07 -78.7, 108.99 -96.75, 5.62 270.16, 92.75 -61.04, -22.45 in-in in 8.9693 Saltbr-in 2.9057 HRD-out -93.55, 75.1 -63.47, -8.59 in-in-out SNCiio in-out ActLoopNT-in 2.9575 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_niii APE10-dihe-na -131.56, -46.56 APE9-dihe-na -57.97, 167.59 APE8-dihe-in -92.57, 68.94 APE8-rot-out 164.5 APE67-dihe-out -70.3, -34.85 61.12, -49.62 APE12-dist-none 999.0 APE11-dist-in 12.5698 APE10-dist-in 6.7414 APE9-dist-in 4.0292 W132R,S164D,T170E None None XRAY 2.78 0.24 0.296 B 371.0 290.0 14 28 19 9 [[12, 295]] 1.0 8r9s CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 6O9L8 P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 7.7977 15.312 None -95.81, -101.98 -119.05, 160.07 -109.44, 53.11 290.95, 162.54 -72.96, -5.74 out-out out 10.6615 Saltbr-out 6.4895 HRD-out -97.79, 80.29 -81.32, 54.89 out-in-out SNCoio in-out ActLoopNT-in 3.4131 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -106.12, -175.8 APE9-dihe-na 68.22, 148.02 APE8-dihe-in -56.94, 134.18 APE8-rot-in 300.57 APE67-dihe-in -70.23, -40.86 -66.35, -19.39 APE12-dist-in 13.7088 APE11-dist-in 13.7987 APE10-dist-out 8.0601 APE9-dist-in 5.0875 None None None EM 7.2 999.0 999.0 8 346.0 299.0 1 28 28 0 [[12, 295]] 1.0 6o9l CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 7EGC8 P50613 13 310 346.0 No_ligand No_ligand Inactive DFGin 5.8793 15.5537 None -116.71, -58.02 -84.26, 100.6 -93.09, 48.78 282.6, 95.84 -80.87, -18.04 in-out in 8.7835 Saltbr-out 3.6643 HRD-out -108.84, 109.5 -77.51, -36.15 out-in-in SNCoii in-in ActLoopNT-in 3.4881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.54, -43.28 APE9-dihe-na -77.94, 146.2 APE8-dihe-in -56.64, 131.6 APE8-rot-in 308.37 APE67-dihe-in -104.38, -21.7 -62.92, -1.65 APE12-dist-in 12.8558 APE11-dist-in 12.6423 APE10-dist-in 6.9139 APE9-dist-in 4.4143 None None None EM 3.9 999.0 999.0 8 346.0 298.0 1 28 28 0 [[12, 295]] 1.0 7egc CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 7ENA8 P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.1587 16.9608 None -137.92, -69.17 -57.97, 126.4 -129.18, 16.9 254.87, 60.55 -63.02, -41.24 in-out in 9.4045 Saltbr-out 5.5294 HRD-out -89.6, 97.27 -59.31, -35.69 out-in-in SNCoii in-in ActLoopNT-in 3.1234 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.33, -53.74 APE9-dihe-na -65.5, 156.02 APE8-dihe-in -61.05, 144.25 APE8-rot-in 317.22 APE67-dihe-in -60.5, -45.43 -56.27, -38.88 APE12-dist-in 12.6274 APE11-dist-in 12.4607 APE10-dist-in 6.9122 APE9-dist-in 4.9505 None None None EM 4.07 999.0 999.0 8 346.0 299.0 1 28 28 0 [[12, 295]] 1.0 7ena CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8BYQ8 P50613 13 310 346.0 No_ligand No_ligand Inactive DFGin 6.883 15.2597 None -127.43, -46.68 -74.13, 79.99 -89.7, 31.43 293.88, 102.94 -76.34, -19.76 in-in in 8.5438 Saltbr-in 2.9389 HRD-out -110.14, 88.9 -51.71, -64.8 in-in-out SNCiio in-out ActLoopNT-in 2.8107 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -112.6, -33.42 APE9-dihe-na -72.79, 145.26 APE8-dihe-in -52.67, 130.55 APE8-rot-in 304.24 APE67-dihe-in -67.92, -7.8 -46.32, -42.89 APE12-dist-out 14.2994 APE11-dist-out 14.0136 APE10-dist-out 8.1268 APE9-dist-in 4.887 None None None EM 4.1 999.0 999.0 8 346.0 298.0 1 28 28 0 [[12, 295]] 1.0 8byq CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8GXQHI P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.1599 16.9603 None -137.77, -69.32 -57.85, 126.33 -129.21, 16.87 254.81, 60.64 -63.11, -41.19 in-na in 9.4051 Saltbr-na 999.0 HRD-out -89.54, 97.16 -59.39, -35.6 na-in-out SNCaio in-out ActLoopNT-in 3.1232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -64.78, -39.13 APE9-dihe-na -69.49, 155.25 APE8-dihe-in -63.89, 150.19 APE8-rot-out 50.1 APE67-dihe-in -62.44, -39.29 -58.88, -44.43 APE12-dist-in 12.6265 APE11-dist-in 12.532 APE10-dist-in 6.5278 APE9-dist-in 5.0977 K41A None None EM 5.04 999.0 999.0 HI 346.0 299.0 1 28 28 0 [[12, 295]] 1.0 8gxq CMGC_CDK7_HUMAN CMGC 5.8e-77 266.6 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8GXSHI P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.1597 16.9609 None -137.74, -69.29 -57.91, 126.39 -129.28, 17.01 254.83, 60.43 -63.16, -41.26 in-na in 9.4047 Saltbr-na 999.0 HRD-out -89.55, 97.29 -59.32, -35.73 na-in-in SNCaii in-in ActLoopNT-in 3.1243 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.36, -53.7 APE9-dihe-na -65.65, 155.95 APE8-dihe-in -61.02, 136.47 APE8-rot-in 317.37 APE67-dihe-in -60.45, -41.25 -41.53, -50.25 APE12-dist-in 12.6262 APE11-dist-in 12.4608 APE10-dist-in 6.9131 APE9-dist-in 4.9494 K41A None None EM 4.16 999.0 999.0 HI 346.0 299.0 1 28 28 0 [[12, 295]] 1.0 8gxs CMGC_CDK7_HUMAN CMGC 5.8e-77 266.6 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 6XD3J P50613 10 312 346.0 V0G:401 Type1 Inactive DFGin 6.4494 15.5688 None -83.3, -65.23 -79.84, 107.47 -100.97, 25.31 275.83, 77.7 -59.79, -36.45 in-out in 7.737 Saltbr-out 3.9352 HRD-out -83.2, 82.34 -68.79, 3.46 out-in-out SNCoio in-out ActLoopNT-in 2.8333 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -91.06, 77.29 APE9-dihe-na -174.12, 154.78 APE8-dihe-in -58.68, 146.66 APE8-rot-out 59.06 APE67-dihe-in -62.31, -31.09 -65.15, -41.16 APE12-dist-in 13.6186 APE11-dist-in 11.5253 APE10-dist-in 6.1269 APE9-dist-in 3.6285 None SEP164 SEP164 EM 3.3 999.0 999.0 J 349.0 298.0 5 28 28 0 [[12, 295]] 1.0 6xd3 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDKL2 CDKL2_HUMAN 4BBMA Q92772 1 308 493.0 TC0:60500 Type1 Inactive DFGin 7.1518 13.3139 None -116.66, 173.28 70.79, 69.66 -144.2, 73.96 44.17, 99.05 132.17, -46.5 out-none out 11.8482 Saltbr-none 999.0 HRD-in -64.8, -48.49 65.16, 11.9 none-out-out SNCnoo out-out ActLoopNT-out 10.2517 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -63.85, -51.88 APE9-dihe-na -56.62, -32.94 APE8-dihe-out -101.86, 5.45 APE8-rot-out 58.5 APE67-dihe-in -66.8, -17.87 -40.06, -47.54 APE12-dist-in 12.3155 APE11-dist-out 16.808 APE10-dist-out 19.4627 APE9-dist-out 9.3714 T159D,Y161E None None XRAY 2.0 0.244 0.269 A 331.0 306.0 2 28 28 0 [[4, 287]] 1.0 4bbm CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CMGC CLK1 CLK1_HUMAN 6KHDA P49759 149 481 484.0 3NG:1000 Type1 Inactive DFGin 6.8618 14.4848 None -115.36, -74.37 -61.99, 112.36 -110.01, 19.25 292.55, 104.1 -59.59, -27.31 in-in in 8.7531 Saltbr-in 2.4552 HRD-in -79.61, -40.92 65.39, -11.49 in-in-out SNCiio in-out ActLoopNT-in 2.9802 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ioon APE10-dihe-na -162.31, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.78, 10.46 999.0, -15.39 APE12-dist-in 11.8684 APE11-dist-out 7.0432 APE10-dist-out 11.6347 APE9-dist-none 999.0 None None None XRAY 2.7 0.204 0.274 A 484.0 322.0 11 25 23 2 [[161, 477]] 1.0 6khd CMGC_CLK1_HUMAN CMGC 8.2e-93 317.4 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CSNK2A2 CSK22_HUMAN 3E3BX P19784 1 334 350.0 CCK:351 Type1 Inactive DFGin 7.9316 16.543 None -60.71, 173.45 58.68, 153.51 -167.77, 24.29 292.11, 94.72 -71.5, -16.51 in-in in 9.9668 Saltbr-in 3.1757 HRD-in -22.7, -49.66 82.48, 4.05 in-in-in SNCiii in-in ActLoopNT-in 3.5364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.37, 167.02 APE9-dihe-na 87.1, -164.84 APE8-dihe-in -118.3, 158.91 APE8-rot-in 284.14 APE67-dihe-in -147.62, -14.08 -66.97, 28.66 APE12-dist-in 13.0394 APE11-dist-in 10.8233 APE10-dist-in 6.2359 APE9-dist-in 3.6473 None None None XRAY 3.2 0.268 0.274 X 339.0 334.0 0 27 27 0 [[40, 325]] 1.0 3e3b CMGC_CSNK2A2_HUMAN CMGC 8.1e-70 241.3 1.0 301.0 301.0 175 176 177 179 181 69 82 86 154 156 155 157.0 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC DYRK1A DYR1A_HUMAN 6UIPA Q13627 131 479 763.0 Q8J:501 Type1 Inactive DFGin 7.3285 15.2923 None -128.98, -33.2 -83.24, -86.92 68.74, 42.73 287.01, 105.17 -106.11, -43.86 in-in in 8.6072 Saltbr-in 2.4441 HRD-in -69.31, -45.72 68.49, 1.14 in-in-in SNCiii in-in ActLoopNT-in 3.0339 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.27, -51.33 APE9-dihe-na -84.83, 157.96 APE8-dihe-in -67.65, 136.35 APE8-rot-in 301.98 APE67-dihe-in -59.01, -29.0 -52.09, -48.51 APE12-dist-in 12.5097 APE11-dist-in 10.8491 APE10-dist-in 6.989 APE9-dist-in 3.2296 None PTR321 PTR321 XRAY 3.7 0.272 0.29 A 361.0 345.0 4 25 25 0 [[159, 479]] 1.0 6uip CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT2A Q13627 134 480 763.0 A1IE6:501 Type1 Inactive DFGin 7.574 15.8948 None -123.41, -159.52 69.59, -109.27 67.33, -3.52 296.76, 96.58 -76.19, -5.59 in-in in 9.1443 Saltbr-in 3.2983 HRD-in -61.34, -38.17 66.08, 9.45 in-out-out SNCioo out-out ActLoopNT-out 4.1136 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -106.57, 172.34 APE9-dihe-na 65.66, 156.83 APE8-dihe-in -69.73, 153.42 APE8-rot-out 183.57 APE67-dihe-in -64.1, -34.34 -62.54, -50.05 APE12-dist-in 11.1649 APE11-dist-in 11.8684 APE10-dist-in 7.9234 APE9-dist-in 3.3634 None PTR321 PTR321 XRAY 2.9 0.212 0.235 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9ft2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT3A Q13627 134 480 763.0 A1IE7:501 Type1 Inactive DFGin 7.5595 15.6952 None -120.59, 174.62 87.74, -111.53 67.1, 10.68 308.34, 93.78 -70.59, -9.71 in-in in 8.8414 Saltbr-in 2.944 HRD-in -61.2, -47.31 80.25, -0.32 in-out-out SNCioo out-out ActLoopNT-out 4.0536 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.45, 165.76 APE9-dihe-na 76.29, 154.85 APE8-dihe-in -77.87, 145.0 APE8-rot-out 181.65 APE67-dihe-in -62.64, -27.73 -60.42, -45.99 APE12-dist-in 11.1415 APE11-dist-in 12.0085 APE10-dist-in 7.9543 APE9-dist-in 3.1564 None PTR321 PTR321 XRAY 2.7 0.196 0.23 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9ft3 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT4A Q13627 134 480 763.0 A1IFJ:501 Type1 Inactive DFGin 7.628 15.7669 None -120.71, -156.86 61.01, -103.63 67.38, -3.25 294.05, 97.87 -71.86, -4.64 in-in in 9.0659 Saltbr-in 3.1765 HRD-in -62.39, -36.73 64.58, 13.09 in-out-out SNCioo out-out ActLoopNT-out 4.0281 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.4, 173.83 APE9-dihe-na 66.37, 159.49 APE8-dihe-in -70.35, 150.45 APE8-rot-out 182.43 APE67-dihe-in -65.5, -29.58 -61.56, -47.55 APE12-dist-in 11.2318 APE11-dist-in 11.9502 APE10-dist-in 7.9178 APE9-dist-in 3.4052 None PTR321 PTR321 XRAY 3.0 0.203 0.237 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9ft4 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT6A Q13627 134 480 763.0 A1IE8:501 Type1 Inactive DFGin 7.5847 15.8164 None -126.75, 170.06 89.43, -106.36 68.66, 5.72 299.38, 96.13 -75.78, -8.95 in-in in 9.146 Saltbr-in 3.3387 HRD-in -60.11, -40.88 70.11, 5.43 in-out-out SNCioo out-out ActLoopNT-out 3.9393 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.56, 172.59 APE9-dihe-na 68.31, 156.56 APE8-dihe-in -68.23, 150.78 APE8-rot-out 177.43 APE67-dihe-in -63.38, -34.6 -61.07, -48.82 APE12-dist-in 11.1848 APE11-dist-in 11.9025 APE10-dist-in 7.8766 APE9-dist-in 3.4151 None PTR321 PTR321 XRAY 3.0 0.209 0.25 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9ft6 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FUFA Q13627 134 480 763.0 A1IFO:501 Type1 Inactive DFGin 7.6694 15.7431 None -124.23, -170.08 74.82, -105.33 66.79, 7.03 297.99, 97.28 -82.54, -3.73 in-in in 9.004 Saltbr-in 3.0075 HRD-in -63.73, -39.36 69.07, 9.77 in-out-out SNCioo out-out ActLoopNT-out 4.1118 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.16, 171.47 APE9-dihe-na 67.5, 156.88 APE8-dihe-in -71.53, 145.53 APE8-rot-out 186.89 APE67-dihe-in -63.53, -27.94 -60.87, -45.06 APE12-dist-in 11.1936 APE11-dist-in 11.939 APE10-dist-in 7.9049 APE9-dist-in 3.3087 None PTR321 PTR321 XRAY 2.7 0.21 0.232 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9fuf CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 9KQYA Q92630 151 537 601.0 No_ligand No_ligand Inactive DFGin 6.5585 15.3057 None -118.46, -58.2 -76.39, 93.69 -100.84, 14.42 280.8, 85.79 -66.94, -30.92 in-in in 8.8424 Saltbr-in 2.9544 HRD-in -69.15, -42.93 69.8, -4.72 in-in-in SNCiii in-in ActLoopNT-in 2.7465 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.16, 173.73 APE9-dihe-na 69.18, 145.61 APE8-dihe-in -65.57, 148.39 APE8-rot-in 308.71 APE67-dihe-in -62.63, -39.04 -60.44, -42.14 APE12-dist-in 13.0235 APE11-dist-in 11.6538 APE10-dist-in 7.1331 APE9-dist-in 3.1497 None PTR382 PTR382 XRAY 3.2 0.233 0.276 A 407.0 387.0 0 25 25 0 [[222, 535]] 1.0 9kqy CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 8HLTB Q92630 151 537 601.0 XSE:60501 Type1 Inactive DFGin 6.6774 15.1725 None -123.1, -45.42 -92.76, 76.97 -82.13, 19.07 287.19, 77.16 -64.05, -27.16 in-in in 8.9659 Saltbr-in 2.9746 HRD-in -75.54, -44.65 72.51, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.7835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.69, 168.46 APE9-dihe-na 73.66, 156.43 APE8-dihe-in -77.8, 146.18 APE8-rot-in 309.51 APE67-dihe-in -59.07, -35.58 -50.16, -47.35 APE12-dist-in 12.9871 APE11-dist-in 11.6227 APE10-dist-in 7.106 APE9-dist-in 3.1243 None PTR382 PTR382 XRAY 2.8 0.213 0.267 B 393.0 387.0 0 25 25 0 [[222, 535]] 1.0 8hlt CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 9KQYB Q92630 151 537 601.0 A1L6I:60501 Type1 Inactive DFGin 6.8416 15.4099 None -119.38, -59.48 -76.49, 94.24 -100.04, 16.54 278.63, 76.93 -66.67, -33.1 in-in in 8.7342 Saltbr-in 2.8484 HRD-in -67.3, -42.38 69.63, -4.95 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 173.43 APE9-dihe-na 69.88, 144.62 APE8-dihe-in -65.72, 149.7 APE8-rot-in 302.89 APE67-dihe-in -61.87, -38.72 -60.58, -43.15 APE12-dist-in 12.5365 APE11-dist-in 11.0539 APE10-dist-in 6.6176 APE9-dist-in 3.2336 None PTR382 PTR382 XRAY 3.2 0.233 0.276 B 407.0 387.0 0 25 25 0 [[222, 535]] 1.0 9kqy CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC GSK3B GSK3B_HUMAN 8QJIA P49841 36 381 420.0 VNG:401 Type1 Inactive DFGin 6.9495 14.1959 None -92.57, -90.5 -72.82, 155.73 -144.36, 17.02 276.05, 102.26 -73.85, -19.5 in-in in 8.3845 Saltbr-in 2.6943 HRD-in -65.27, -43.08 63.67, 22.78 in-in-out SNCiio in-out ActLoopNT-in 3.34 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.54, 179.17 APE9-dihe-na 65.4, 161.24 APE8-dihe-in -68.89, 150.02 APE8-rot-out 175.4 APE67-dihe-in -64.21, -18.12 -58.7, -47.99 APE12-dist-in 13.3857 APE11-dist-in 12.0024 APE10-dist-in 7.07 APE9-dist-in 3.4473 None PTR216 PTR216 XRAY 3.02 0.253 0.289 A 364.0 340.0 6 27 27 0 [[56, 340]] 1.0 8qji CMGC_GSK3B_HUMAN CMGC 2e-70 243.5 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK10 MK10_HUMAN 3OXIA P53779 46 400 464.0 SYY:60001 Type1 Inactive DFGin 4.7853 13.3158 None -65.65, -67.29 -149.24, -142.55 -154.51, 112.55 32.12, 89.18 -52.06, 999.0 in-in in 9.8126 Saltbr-in 2.8472 HRD-in -69.6, -55.6 74.47, -18.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.07 APE8-dihe-in -67.1, 115.71 APE8-rot-in 310.72 APE67-dihe-in -75.18, -9.96 -113.13, 12.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4824 None None None XRAY 2.2 0.232 0.275 A 362.0 322.0 19 27 12 15 [[64, 359]] 1.0 3oxi CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 3PTGA P53779 46 401 464.0 932:60001 Type1 Inactive DFGin 3.7132 13.1579 None -76.5, -95.65 -85.65, -153.0 -174.62, 83.6 38.12, 37.79 -80.26, -75.99 in-in in 8.9492 Saltbr-in 2.713 HRD-in -82.38, -47.37 67.19, -16.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -33.68 APE8-dihe-out 167.39, -0.43 APE8-rot-out 180.66 APE67-dihe-in -48.92, -26.13 -62.89, -39.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8039 None None None XRAY 2.43 0.247 0.316 A 363.0 340.0 16 27 14 13 [[64, 359]] 1.0 3ptg CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 1PMVA P53779 45 400 464.0 537:501 Type1 Inactive DFGin 4.2247 14.7388 None -81.65, -103.82 -56.07, 179.4 -108.34, 6.78 292.4, 71.45 88.17, -161.99 out-out out 10.0434 Saltbr-out 5.5021 HRD-in -44.57, -73.88 76.33, -1.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -55.4, 164.21 APE9-dihe-na -103.96, 46.79 APE8-dihe-in -57.98, 139.58 APE8-rot-in 313.89 APE67-dihe-in -60.79, -25.59 -166.19, 12.11 APE12-dist-out 19.3858 APE11-dist-in 13.7304 APE10-dist-out 15.5802 APE9-dist-out 12.2546 None None None XRAY 2.5 0.222 0.282 A 364.0 347.0 5 27 22 5 [[64, 359]] 1.0 1pmv CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 8VS0A P53779 45 400 464.0 A1ACT:501 Type1 Inactive DFGin 4.0117 14.6105 None -113.83, -24.3 -131.4, -10.59 66.04, -11.26 300.28, 122.45 85.3, -162.24 out-out out 10.0307 Saltbr-out 5.9637 HRD-in -58.98, -68.6 78.5, 4.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.17, 144.09 APE9-dihe-na -84.41, 142.6 APE8-dihe-in -87.18, 136.96 APE8-rot-in 297.81 APE67-dihe-in -68.04, -18.46 -128.93, 1.97 APE12-dist-out 21.4943 APE11-dist-out 16.3645 APE10-dist-out 16.3116 APE9-dist-out 11.3764 None None None XRAY 2.46 0.198 0.25 A 464.0 346.0 5 27 22 5 [[64, 359]] 1.0 8vs0 CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK11 MK11_HUMAN 3GC9A Q15759 3 348 364.0 B45:365 Type1 Inactive DFGin 4.5577 14.0834 None -99.4, 135.63 55.61, 168.55 -126.62, 27.34 309.47, 109.49 93.22, 8.24 in-out in 9.6686 Saltbr-out 4.0554 HRD-in -70.45, -55.0 82.48, -18.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.74 APE8-dihe-in -70.43, 137.59 APE8-rot-out 173.62 APE67-dihe-in -61.21, -17.49 -105.03, 7.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6952 C119S,C162S None None XRAY 2.05 0.224 0.275 A 370.0 335.0 11 25 14 11 [[24, 308]] 1.0 3gc9 CMGC_MAPK11_HUMAN CMGC 1.6e-82 283.1 4.0 301.0 298.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 11
CMGC MAPK14 MK14_HUMAN 4E6AA Q16539 4 351 360.0 0O9:500 Allosteric Inactive DFGin 7.8292 16.7355 None -116.35, 173.04 63.5, -177.46 -171.04, 999.0 277.86, 82.56 999.0, 999.0 in-in in 9.4716 Saltbr-in 2.9275 HRD-in -64.73, -56.61 86.56, -18.31 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -58.14, -22.79 999.0, 21.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.09 0.224 0.273 A 360.0 324.0 23 25 9 16 [[24, 308]] 1.0 4e6a CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E6CA Q16539 4 351 360.0 0O8:500 Allosteric Inactive DFGin 7.12 15.5419 None -107.87, 169.94 71.07, 48.65 -62.86, 999.0 316.7, 83.95 999.0, 999.0 in-in in 9.053 Saltbr-in 3.1301 HRD-in -64.38, -54.16 91.01, -29.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.63 APE8-rot-out 211.4 APE67-dihe-in -58.37, -26.81 -122.63, 18.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.22 0.292 A 360.0 330.0 18 25 10 15 [[24, 308]] 1.0 4e6c CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5N67A Q16539 5 353 360.0 8ON:401 Allosteric Inactive DFGin 6.8653 15.6092 None -128.23, -179.23 57.11, 61.45 -58.51, 999.0 306.28, 87.84 999.0, 999.0 in-in in 9.4444 Saltbr-in 3.0167 HRD-in -67.68, -53.37 80.76, -14.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.97 APE8-dihe-out -66.09, -43.78 APE8-rot-in 291.76 APE67-dihe-in -63.81, -23.7 -63.35, -24.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7672 None None None XRAY 1.9 0.191 0.222 A 360.0 327.0 22 25 11 14 [[24, 308]] 1.0 5n67 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 8X3MA Q16539 4 353 360.0 B8Z:401 Allosteric Inactive DFGin 7.7119 16.8556 None -115.94, 168.03 71.62, -88.99 88.0, 131.81 286.06, 88.99 -70.61, 105.76 in-in in 9.6027 Saltbr-in 3.0578 HRD-in -66.17, -53.58 79.95, -8.82 in-out-out SNCioo out-out ActLoopNT-out 10.5579 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.62, 133.04 APE9-dihe-na -62.46, -10.4 APE8-dihe-out -67.81, -17.48 APE8-rot-out 51.83 APE67-dihe-in -60.97, -25.8 -116.4, -18.75 APE12-dist-out 22.0398 APE11-dist-out 24.1061 APE10-dist-out 18.4386 APE9-dist-out 11.7912 None None None XRAY 1.85 0.183 0.226 A 365.0 350.0 0 25 25 0 [[24, 308]] 1.0 8x3m CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4DLIA Q16539 5 354 360.0 IRG:401,IRG:402 Allosteric,Allosteric Inactive DFGin 9.8147 11.8562 None -104.36, 150.39 -73.0, -47.15 -137.92, 126.59 314.79, 100.08 -44.68, 999.0 in-in in 9.4387 Saltbr-in 2.8448 HRD-in -68.95, -53.08 77.7, -11.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 123.1 APE9-dihe-na -70.95, 129.15 APE8-dihe-out -52.5, -43.49 APE8-rot-in 288.97 APE67-dihe-in -64.32, -23.54 -55.51, -29.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0955 None None None XRAY 1.91 0.216 0.255 A 360.0 334.0 16 25 13 12 [[24, 308]] 1.0 4dli CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EH4A Q16539 4 354 360.0 IRG:401,0OL:402 Allosteric,Type1 Inactive DFGin 10.8466 12.1969 None -91.43, 145.17 -57.64, -47.01 -148.78, 133.96 289.87, 102.95 -106.02, 178.5 in-in in 9.3455 Saltbr-in 3.5333 HRD-in -75.34, -49.4 79.8, -22.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 89.91 APE9-dihe-na -88.64, 150.01 APE8-dihe-out -60.61, -41.02 APE8-rot-in 254.43 APE67-dihe-in -62.83, -20.65 -63.82, -26.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.1023 APE9-dist-out 11.2223 None None None XRAY 2.5 0.234 0.317 A 360.0 337.0 14 25 15 10 [[24, 308]] 1.0 4eh4 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3C5UA Q16539 4 352 360.0 P41:361,P41:362 Allosteric,Type1 Inactive DFGin 5.9263 14.6107 None -79.99, -52.08 -111.86, 147.19 165.52, 164.69 70.95, 141.36 -178.3, -57.28 in-in in 9.4101 Saltbr-in 2.8949 HRD-in -58.08, -50.48 77.9, -18.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 89.15 APE9-dihe-na -79.53, 169.16 APE8-dihe-in -115.39, 178.62 APE8-rot-out 194.24 APE67-dihe-out 106.71, -27.43 -78.01, -142.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.0025 APE9-dist-out 13.5624 None None None XRAY 2.8 0.263 0.296 A 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 3c5u CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E5AX Q16539 3 353 360.0 No_ligand No_ligand Inactive DFGin 7.4271 16.6777 None -111.06, 176.17 53.13, 71.95 -70.18, 999.0 294.84, 64.48 999.0, 999.0 in-in in 9.576 Saltbr-in 3.5066 HRD-in -71.06, -54.61 88.3, -21.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 105.51 APE8-dihe-in -65.33, 145.05 APE8-rot-out 181.03 APE67-dihe-in -68.36, -17.57 -107.7, 17.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7943 W197A None None XRAY 1.87 0.219 0.253 X 360.0 332.0 19 25 11 14 [[24, 308]] 1.0 4e5a CMGC_MAPK14_HUMAN CMGC 5.7e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OD6X Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.1693 14.5472 None -107.32, -35.37 -122.54, 110.88 -101.89, 179.03 304.51, 65.36 116.69, -52.36 in-in in 9.7055 Saltbr-in 3.5749 HRD-out -70.82, 103.82 -92.19, 25.39 in-in-out SNCiio in-out ActLoopNT-in 2.9041 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -86.05, 124.21 APE9-dihe-na 179.03, 165.34 APE8-dihe-in -50.68, 120.55 APE8-rot-in 316.14 APE67-dihe-in -54.18, -37.51 -81.72, -17.02 APE12-dist-in 10.2458 APE11-dist-out 6.7415 APE10-dist-out 9.7315 APE9-dist-out 7.1949 Y323T None None XRAY 2.682 0.215 0.283 X 360.0 344.0 5 25 25 0 [[24, 308]] 1.0 3od6 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OEFX Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 4.9023 12.1341 None -108.05, 167.45 -157.07, -159.47 61.31, 35.4 325.61, 112.03 64.1, 24.95 in-in in 8.824 Saltbr-in 2.7137 HRD-in -68.42, -53.79 78.26, -14.32 in-out-none SNCion out-none ActLoopNT-out 17.9811 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.36 APE8-rot-in 260.2 APE67-dihe-in -60.02, -22.95 -112.04, 6.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 Y323F None None XRAY 1.6 0.187 0.221 X 360.0 334.0 14 25 14 11 [[24, 308]] 1.0 3oef CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ODYX Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.2927 14.9518 None -99.56, -49.69 -113.79, 73.73 -150.67, 152.99 55.1, 98.03 53.69, 11.06 out-out out 11.8635 Saltbr-out 8.8242 HRD-out -75.99, 166.59 -145.03, -3.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 113.54 APE9-dihe-na -84.24, -15.35 APE8-dihe-out -79.73, -37.47 APE8-rot-in 312.81 APE67-dihe-in -57.52, -26.46 -53.29, -32.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9259 APE9-dist-out 11.0075 Y323Q None None XRAY 2.2 0.238 0.304 X 360.0 321.0 29 25 15 10 [[24, 308]] 1.0 3ody CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MGYA Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.8489 15.4078 None -96.6, 163.16 144.18, -87.53 -41.62, 999.0 25.94, 59.9 999.0, 999.0 in-in in 9.8726 Saltbr-in 2.9683 HRD-in -64.11, -58.21 85.85, 0.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 165.22 APE8-rot-out 214.38 APE67-dihe-in -69.5, -24.6 -110.92, 8.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.243 0.291 A 360.0 329.0 19 25 10 15 [[24, 308]] 1.0 3mgy CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E5BA Q16539 4 351 360.0 No_ligand No_ligand Inactive DFGin 7.7496 16.4477 None -109.02, 158.46 31.08, 83.24 -71.5, 999.0 299.95, 31.84 999.0, 999.0 in-in in 9.2652 Saltbr-in 2.8145 HRD-in -56.8, -65.03 90.55, -13.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.6, -23.21 999.0, 23.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.237 0.279 A 360.0 324.0 23 25 9 16 [[24, 308]] 1.0 4e5b CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ODZX Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.0644 15.3431 None -127.95, -15.93 -113.67, 56.52 -144.01, 156.75 54.25, 120.62 60.75, 23.2 out-out out 11.618 Saltbr-out 9.0277 HRD-out -65.57, 130.15 -105.04, 19.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.07 APE9-dihe-na -94.07, 5.61 APE8-dihe-in -177.03, 113.52 APE8-rot-out 172.92 APE67-dihe-in -61.07, -28.1 -95.52, 3.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.3127 APE9-dist-out 12.5093 Y323R None None XRAY 2.3 0.223 0.282 X 360.0 335.0 15 25 15 10 [[24, 308]] 1.0 3odz CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5ETCA Q16539 1 352 360.0 No_ligand No_ligand Inactive DFGin 7.9268 17.5065 None -109.69, 177.11 57.89, 82.77 -103.25, -87.08 272.53, 90.11 -31.01, -89.71 in-out in 9.7017 Saltbr-out 3.6009 HRD-in -68.38, -45.82 79.56, -12.49 out-out-out SNCooo out-out ActLoopNT-out 10.994 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -140.41, 139.5 APE9-dihe-na -66.28, -17.2 APE8-dihe-out -69.09, -9.59 APE8-rot-out 56.2 APE67-dihe-in -64.25, -22.37 -125.41, -16.44 APE12-dist-out 21.1759 APE11-dist-out 23.1029 APE10-dist-out 17.3278 APE9-dist-out 11.8982 None None None XRAY 2.422 0.197 0.242 A 363.0 352.0 0 25 25 0 [[24, 308]] 1.0 5etc CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WFCA Q16539 5 351 360.0 No_ligand No_ligand Inactive DFGin 7.6408 16.6525 None -118.35, 179.66 63.95, -92.6 123.2, 999.0 266.78, 80.69 999.0, 999.0 in-out in 9.5424 Saltbr-out 3.6831 HRD-in -80.8, -27.0 48.37, 14.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -129.45, 133.38 APE9-dihe-na -57.59, -22.46 APE8-dihe-out -57.94, -20.68 APE8-rot-out 53.19 APE67-dihe-in -65.99, -19.65 -113.55, -17.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7898 None None None XRAY 2.3 0.213 0.297 A 366.0 340.0 5 25 20 5 [[24, 308]] 1.0 1wfc CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MH0A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 8.4153 16.8838 None -94.37, 151.84 67.81, 17.94 -52.66, 126.59 999.0, 999.0 86.82, 1.89 in-in in 9.3128 Saltbr-in 2.9134 HRD-in -65.91, -50.91 79.65, -20.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.01 APE8-rot-out 35.18 APE67-dihe-in -59.42, -23.13 -101.48, 7.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169A None None XRAY 2.0 0.232 0.28 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3mh0 CMGC_MAPK14_HUMAN CMGC 1.1e-83 287.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3IW6A Q16539 4 353 360.0 PP0:361 Type1 Inactive DFGin 10.6593 12.8022 None -107.45, 146.07 -62.15, -52.96 -135.84, 140.51 306.3, 96.66 -100.47, -175.96 in-in in 8.9094 Saltbr-in 2.7027 HRD-in -68.9, -58.44 84.06, -12.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 89.13 APE9-dihe-na -68.25, 143.74 APE8-dihe-out -81.14, -28.36 APE8-rot-out 119.31 APE67-dihe-in -61.88, -28.19 -54.39, -28.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.738 APE9-dist-out 12.6069 C119S,C162S,A172C,F327L None None XRAY 2.1 0.213 0.273 A 360.0 337.0 13 25 14 11 [[24, 308]] 1.0 3iw6 CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3IW7A Q16539 4 352 360.0 IPK:361 Type1 Inactive DFGin 10.7835 12.9675 None -101.08, 142.65 -64.35, -57.15 -132.52, 130.32 305.61, 101.42 -90.75, 171.73 in-in in 9.027 Saltbr-in 3.0854 HRD-in -64.07, -57.02 86.6, -16.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.97 APE8-dihe-out -80.2, 2.17 APE8-rot-out 181.73 APE67-dihe-in -62.05, -22.02 -116.3, -9.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0592 C119S,C162S,A172C,F327L None None XRAY 2.4 0.203 0.282 A 360.0 335.0 14 25 13 12 [[24, 308]] 1.0 3iw7 CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2BAQA Q16539 5 351 360.0 PQB:401 Type1 Inactive DFGin 10.3272 11.741 None -89.31, 142.2 -51.16, -47.94 -140.37, 153.62 295.29, 101.84 -84.84, -141.61 in-in in 8.4503 Saltbr-in 2.9936 HRD-in -54.23, -50.45 81.43, -10.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -91.51, 119.1 APE9-dihe-na -74.33, 131.38 APE8-dihe-out -51.32, -39.83 APE8-rot-in 282.97 APE67-dihe-in -50.36, -10.98 -69.35, -26.54 APE12-dist-none 999.0 APE11-dist-in 10.1777 APE10-dist-out 10.48 APE9-dist-out 11.6645 V30I None CSS162 XRAY 2.8 0.222 0.296 A 365.0 330.0 17 25 16 9 [[24, 308]] 1.0 2baq CMGC_MAPK14_HUMAN CMGC 4e-85 291.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WBOA Q16539 4 354 360.0 2CH:1355 Type1 Inactive DFGin 7.5035 16.9555 None -102.06, -162.61 -36.66, 129.23 -76.33, 147.94 286.93, 61.58 -66.99, 104.73 in-in in 9.724 Saltbr-in 2.7727 HRD-in -73.99, -52.37 82.98, -14.31 in-out-out SNCioo out-out ActLoopNT-out 10.5915 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.64, 132.01 APE9-dihe-na -58.44, -25.39 APE8-dihe-out -53.56, -33.51 APE8-rot-out 45.91 APE67-dihe-in -69.56, -19.55 -106.13, -10.44 APE12-dist-out 21.7087 APE11-dist-out 23.849 APE10-dist-out 18.1619 APE9-dist-out 11.712 None None None XRAY 2.16 0.167 0.22 A 360.0 351.0 0 25 25 0 [[24, 308]] 1.0 1wbo CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5OMGA Q16539 4 353 360.0 9Y8:402 Type1 Inactive DFGin 10.9259 12.75 None -99.59, 155.64 -73.45, -50.39 -143.59, 137.7 303.2, 98.46 -92.47, -157.32 in-in in 9.0658 Saltbr-in 3.1972 HRD-in -65.81, -53.84 75.16, -16.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 84.11 APE9-dihe-na -56.7, 137.85 APE8-dihe-out -66.22, -35.89 APE8-rot-out 184.11 APE67-dihe-in -59.63, -25.96 -58.79, -27.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.0608 APE9-dist-out 11.9487 None None None XRAY 2.0 0.186 0.245 A 360.0 337.0 13 25 15 10 [[24, 308]] 1.0 5omg CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9YTYA Q16539 4 353 360.0 A1BB6:402 Type1 Inactive DFGin 4.6111 13.1622 None -120.16, 162.46 56.72, 51.46 -84.98, 999.0 26.65, 85.72 999.0, 999.0 in-in in 9.4594 Saltbr-in 2.8615 HRD-in -70.78, -49.19 75.68, -17.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.8 APE8-dihe-out -66.34, -34.75 APE8-rot-in 298.99 APE67-dihe-in -64.81, -21.23 -60.57, -20.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7554 None None None XRAY 2.25 0.211 0.254 A 360.0 336.0 14 25 11 14 [[24, 308]] 1.0 9yty CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUDA Q16539 4 354 360.0 N3F:361 Type1 Inactive DFGin 10.8012 12.5528 None -93.66, 153.34 -68.51, -47.3 -136.82, 128.38 301.98, 103.1 -95.02, -166.54 in-in in 9.269 Saltbr-in 3.5549 HRD-in -63.42, -58.28 80.41, -12.58 in-out-out SNCioo out-out ActLoopNT-out 20.8014 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.75 APE9-dihe-na -76.37, 136.79 APE8-dihe-out -65.47, -38.0 APE8-rot-in 295.71 APE67-dihe-in -57.05, -26.46 -56.48, -28.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.7622 APE9-dist-out 12.6517 None None None XRAY 2.0 0.234 0.278 A 360.0 345.0 6 25 19 6 [[24, 308]] 1.0 3qud CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUEA Q16539 5 353 360.0 3FF:362 Type1 Inactive DFGin 10.6415 12.3386 None -82.41, 155.86 -75.27, -54.23 -130.98, 134.23 308.77, 88.25 -97.08, -170.31 in-in in 8.9604 Saltbr-in 2.6567 HRD-in -64.83, -54.13 86.66, -27.06 in-out-out SNCioo out-out ActLoopNT-out 21.2792 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 66.84 APE9-dihe-na -77.78, 135.56 APE8-dihe-out -48.89, -54.16 APE8-rot-in 280.74 APE67-dihe-in -53.38, -25.8 -51.95, -34.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1952 APE9-dist-out 11.3927 None None None XRAY 2.7 0.23 0.311 A 360.0 343.0 6 25 19 6 [[24, 308]] 1.0 3que CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZSIA Q16539 6 352 360.0 52P:1000 Type1 Inactive DFGin 10.4689 12.2756 None -99.24, 157.46 -83.12, -44.9 -141.74, 118.5 319.2, 96.5 -93.21, -169.85 in-in in 8.8878 Saltbr-in 3.0614 HRD-in -68.1, -49.59 77.07, -12.99 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.82 APE8-rot-in 291.48 APE67-dihe-in -55.25, -30.12 -56.65, -32.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.234 0.271 A 362.0 326.0 21 25 12 13 [[24, 308]] 1.0 3zsi CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9MHBA Q16539 4 353 360.0 A1BLA:401 Type1 Inactive DFGin 7.102 16.2712 None -117.98, 165.25 51.74, 50.71 -38.59, 999.0 301.84, 11.59 999.0, 999.0 in-in in 9.4983 Saltbr-in 2.8857 HRD-in -70.02, -56.7 79.98, -12.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -51.26 APE9-dihe-na -76.26, 128.02 APE8-dihe-out -60.23, -38.8 APE8-rot-in 294.53 APE67-dihe-in -63.02, -23.59 -57.69, -25.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5631 None None CME162 XRAY 1.65 0.174 0.202 A 362.0 337.0 13 25 12 13 [[24, 308]] 1.0 9mhb CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FC1X Q16539 5 353 360.0 52P:362 Type1 Inactive DFGin 7.1239 15.1868 None -126.14, -173.97 53.21, -144.46 158.6, 119.78 279.97, 109.61 999.0, 999.0 in-in in 9.0296 Saltbr-in 2.6197 HRD-in -59.7, -53.23 81.3, -16.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -128.32, 135.87 APE9-dihe-na -60.12, -21.5 APE8-dihe-out -62.23, -25.4 APE8-rot-out 50.45 APE67-dihe-in -63.14, -19.02 -109.22, -16.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2558 None None None XRAY 2.4 0.204 0.251 X 366.0 334.0 13 25 17 8 [[24, 308]] 1.0 3fc1 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3BV2A Q16539 5 351 360.0 P38:501 Type1 Inactive DFGin 10.9192 11.9511 None -130.49, -172.23 -144.15, 148.34 64.11, 33.68 315.43, 116.87 -55.63, 125.6 in-in in 9.1734 Saltbr-in 2.72 HRD-in -59.8, -67.17 84.25, -8.03 in-out-out SNCioo out-out ActLoopNT-out 21.9505 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 115.36 APE8-dihe-out -57.65, -17.83 APE8-rot-out 225.25 APE67-dihe-in -64.72, -27.84 -71.88, -20.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1463 None None None XRAY 2.4 0.209 0.263 A 366.0 337.0 10 25 15 10 [[24, 308]] 1.0 3bv2 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OCGA Q16539 4 352 360.0 OCG:361 Type1 Inactive DFGin 5.2198 14.3908 None -93.64, -75.59 -102.1, 63.24 -58.64, -80.69 42.2, 96.84 -84.43, 26.24 in-in in 9.0686 Saltbr-in 2.6197 HRD-in -63.56, -51.33 77.03, -20.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 103.73 APE8-rot-out 176.87 APE67-dihe-in -64.6, -19.08 -164.89, -32.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.214 0.27 A 366.0 336.0 13 25 12 13 [[24, 308]] 1.0 3ocg CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2GFSA Q16539 5 352 360.0 PQB:361 Type1 Inactive DFGin 7.4894 16.1685 None -132.16, -175.45 50.97, 60.34 -61.94, 999.0 284.15, 70.88 999.0, 999.0 in-in in 9.1388 Saltbr-in 2.7264 HRD-in -67.49, -53.73 80.94, -11.52 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -137.15, 132.57 APE9-dihe-na -61.35, -21.8 APE8-dihe-out -55.56, -23.97 APE8-rot-out 51.68 APE67-dihe-in -64.89, -19.57 -114.73, -17.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0158 None None None XRAY 1.752 0.206 0.239 A 372.0 344.0 4 25 21 4 [[24, 308]] 1.0 2gfs CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FMLA Q16539 4 352 360.0 FML:361 Type1 Inactive DFGin 7.3213 16.1677 None -113.5, 169.93 78.68, -95.68 95.06, 999.0 286.66, 90.12 999.0, 999.0 in-in in 9.4074 Saltbr-in 2.6446 HRD-in -67.48, -49.5 80.29, -18.01 in-out-out SNCioo out-out ActLoopNT-out 10.2813 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.68, 134.28 APE9-dihe-na -62.37, -13.16 APE8-dihe-out -68.44, -18.97 APE8-rot-out 59.25 APE67-dihe-in -63.75, -24.61 -116.53, -16.96 APE12-dist-out 21.7069 APE11-dist-out 23.7308 APE10-dist-out 17.9821 APE9-dist-out 11.9013 None None None XRAY 2.1 0.216 0.245 A 372.0 342.0 7 25 24 1 [[24, 308]] 1.0 3fml CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FSKA Q16539 5 352 360.0 RO6:450 Type1 Inactive DFGin 7.5793 16.3094 None -136.71, -175.6 44.08, 65.21 -58.68, 999.0 291.46, 58.68 999.0, 999.0 in-in in 9.2711 Saltbr-in 2.5853 HRD-in -71.16, -52.26 76.45, -12.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -137.29, 134.45 APE9-dihe-na -62.73, -15.05 APE8-dihe-out -64.93, -17.06 APE8-rot-out 49.49 APE67-dihe-in -61.37, -23.14 -117.2, -17.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9695 None None None XRAY 2.0 0.207 0.243 A 372.0 342.0 6 25 19 6 [[24, 308]] 1.0 3fsk CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HA8A Q16539 4 352 360.0 5JZ:361 Type1 Inactive DFGin 7.6116 16.3381 None -141.16, 163.83 56.43, 72.99 -75.34, 999.0 309.72, 73.83 999.0, 999.0 in-out in 9.8651 Saltbr-out 4.0704 HRD-in -63.56, -51.44 79.66, -26.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -132.89, 139.9 APE9-dihe-na -58.34, -25.0 APE8-dihe-out -56.24, -14.15 APE8-rot-out 54.17 APE67-dihe-in -68.66, -11.09 -127.46, -12.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1308 None None None XRAY 2.48 0.217 0.248 A 379.0 342.0 7 25 18 7 [[24, 308]] 1.0 3ha8 CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4F9WA Q16539 5 352 360.0 LM4:403 Type1 Inactive DFGin 7.7255 16.584 None -80.52, 176.23 -63.07, 104.95 -100.59, 2.82 54.46, 75.64 130.88, -79.74 in-out in 9.4539 Saltbr-out 4.5982 HRD-in -68.07, -55.53 83.11, -14.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 138.42 APE8-dihe-out -55.74, -38.36 APE8-rot-in 282.33 APE67-dihe-in -59.63, -26.4 -42.98, -44.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3918 None None None XRAY 2.0 0.173 0.216 A 383.0 336.0 12 25 13 12 [[24, 308]] 1.0 4f9w CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4FA2A Q16539 4 353 360.0 SB0:402 Type1 Inactive DFGin 8.1265 13.3665 None -98.53, 119.73 -70.7, -31.65 -138.38, 143.95 311.3, 93.7 107.84, 75.14 in-in in 9.0918 Saltbr-in 2.481 HRD-in -68.79, -53.09 81.55, -18.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -80.2 APE9-dihe-na -62.71, 131.19 APE8-dihe-out -61.7, -39.74 APE8-rot-in 283.35 APE67-dihe-in -60.81, -26.39 -57.15, -28.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1525 APE9-dist-out 11.2807 None None None XRAY 2.0 0.174 0.215 A 383.0 339.0 11 25 14 11 [[24, 308]] 1.0 4fa2 CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4ZTHA Q16539 4 353 360.0 VVT:401 Type1 Inactive DFGin 8.3008 13.855 None -89.83, 123.18 -77.72, -39.39 -125.61, 120.62 298.26, 98.01 -83.63, -144.08 in-in in 9.2036 Saltbr-in 2.9023 HRD-in -71.36, -49.73 75.36, -10.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -91.32 APE9-dihe-na -69.69, 130.87 APE8-dihe-out -61.18, -39.46 APE8-rot-in 289.92 APE67-dihe-in -57.67, -28.49 -59.49, -25.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5913 APE9-dist-out 11.6954 None None None XRAY 2.15 0.184 0.24 A 383.0 339.0 11 25 14 11 [[24, 308]] 1.0 4zth CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9O4LA Q16539 5 353 360.0 A1B8B:402 Type1 Inactive DFGin 5.0897 15.55 None -133.08, 171.57 61.65, 21.84 -73.72, 999.0 76.92, 114.61 999.0, 999.0 in-in in 9.488 Saltbr-in 2.7441 HRD-in -65.15, -53.31 77.94, -18.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.35 APE8-rot-in 324.94 APE67-dihe-out -67.13, -12.17 -110.61, 107.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.193 0.241 A 384.0 334.0 15 25 10 15 [[24, 308]] 1.0 9o4l CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3O8PA Q16539 5 351 360.0 BMU:361 Type1 Inactive DFGin 10.8634 12.0139 None -115.52, 162.58 -99.08, -26.53 -122.71, 117.21 291.85, 138.97 -42.63, -102.67 in-out in 9.092 Saltbr-out 5.0854 HRD-in -69.17, -52.21 73.92, -4.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 3.16 APE9-dihe-na -166.83, -167.55 APE8-dihe-out -116.39, -25.53 APE8-rot-in 271.29 APE67-dihe-in -61.81, -26.71 -69.76, -21.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.1587 APE9-dist-out 10.4529 D168G None None XRAY 2.1 0.218 0.276 A 360.0 336.0 11 25 14 11 [[24, 308]] 1.0 3o8p CMGC_MAPK14_HUMAN CMGC 2.7e-83 285.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OBGA Q16539 5 352 360.0 SB2:361 Type1 Inactive DFGin 8.5471 15.5472 None -95.25, 144.72 58.8, 33.65 -69.14, 75.21 999.0, 999.0 119.93, 18.42 in-in in 9.1521 Saltbr-in 2.4857 HRD-in -65.99, -57.89 82.28, -14.21 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.23 APE8-rot-in 336.97 APE67-dihe-in -54.89, -27.15 -56.97, -19.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169G None None XRAY 2.8 0.222 0.323 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3obg CMGC_MAPK14_HUMAN CMGC 3e-83 285.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9D75A Q16539 5 353 360.0 A1A2L:60401 Type1 Inactive DFGin 7.2315 15.7878 None -119.44, 171.6 35.49, 86.57 -63.81, 999.0 294.63, 49.65 -63.81, 999.0 in-in in 9.0602 Saltbr-in 2.5179 HRD-in -70.24, -56.4 84.64, -17.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -1.29 APE8-rot-out 180.89 APE67-dihe-out -73.6, -14.85 -63.9, 126.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.13 0.208 0.236 A 346.0 335.0 11 25 14 11 [[24, 308]] 1.0 9d75 CMGC_MAPK14_HUMAN CMGC 1e-79 273.9 1.0 301.0 301.0 167 168 169 173 175 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9D7NA Q16539 5 353 360.0 A1A2O:60401 Type1 Inactive DFGin 6.7111 15.4176 None -125.4, 169.42 35.27, 85.02 -62.1, 999.0 300.08, 66.43 -62.1, 999.0 in-in in 9.1287 Saltbr-in 2.51 HRD-in -66.23, -52.52 80.02, -15.24 in-out-none SNCion out-none ActLoopNT-out 6.9136 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.33, -14.88 999.0, 144.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.973 0.214 0.257 A 346.0 337.0 9 25 16 9 [[24, 308]] 1.0 9d7n CMGC_MAPK14_HUMAN CMGC 1.3e-79 273.6 1.0 301.0 301.0 167 168 169 173 175 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EWQA Q16539 5 353 360.0 MWL:402,MWL:403 Type1,Allosteric Inactive DFGin 5.0183 13.3955 None -118.78, 173.31 61.29, 10.97 -62.77, 999.0 41.58, 86.71 999.0, 999.0 in-in in 9.2208 Saltbr-in 2.7732 HRD-in -66.73, -55.27 77.04, -7.68 in-out-out SNCioo out-out ActLoopNT-out 7.2789 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -109.0, 120.47 APE9-dihe-na -53.91, -56.01 APE8-dihe-in -144.08, 143.87 APE8-rot-out 173.18 APE67-dihe-out -56.97, -22.68 -121.19, 104.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2577 None TPO180 TPO180 XRAY 2.1 0.182 0.229 A 383.0 347.0 2 25 23 2 [[24, 308]] 1.0 4ewq CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4R3CA Q16539 4 352 360.0 3GF:402,3GF:403 Type1,Allosteric Inactive DFGin 4.9243 13.1341 None -118.67, 171.2 49.4, 42.48 -86.86, 999.0 38.51, 75.43 999.0, 999.0 in-out in 9.5432 Saltbr-out 3.9084 HRD-in -66.01, -56.32 81.1, -14.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 103.85 APE9-dihe-na -65.1, 130.86 APE8-dihe-out -51.86, -39.46 APE8-rot-in 289.55 APE67-dihe-in -62.53, -25.36 -48.44, -37.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2638 None None CME162 XRAY 2.06 0.178 0.217 A 383.0 336.0 13 25 12 13 [[24, 308]] 1.0 4r3c CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9NYTA Q16539 5 353 360.0 A1B7S:402,F50:404 Type1,Allosteric Inactive DFGin 4.2601 13.0797 None -116.13, 155.51 78.56, -1.77 -37.34, 999.0 47.87, 84.48 999.0, 999.0 in-out in 9.5555 Saltbr-out 4.0805 HRD-in -71.88, -52.7 83.59, -21.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.66 APE8-dihe-out -70.34, -25.73 APE8-rot-out 87.71 APE67-dihe-in -59.45, -18.84 -59.85, -29.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5386 None None None XRAY 2.16 0.195 0.24 A 384.0 335.0 14 25 11 14 [[24, 308]] 1.0 9nyt CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP2A Q16539 4 355 360.0 P36:401,I46:402,I46:403 Type1,Allosteric,Allosteric Inactive DFGin 10.3229 12.0791 None -88.89, 117.93 0.95, -90.69 -132.19, 144.91 307.84, 89.53 -100.53, 179.64 in-in in 8.9859 Saltbr-in 3.0157 HRD-in -62.69, -56.28 83.82, -16.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -83.28 APE9-dihe-na -69.46, 121.84 APE8-dihe-out -57.79, -33.94 APE8-rot-in 290.47 APE67-dihe-in -56.52, -29.08 -65.16, -23.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8086 APE9-dist-out 11.9697 None None None XRAY 2.15 0.208 0.252 A 360.0 341.0 11 25 14 11 [[24, 308]] 1.0 3hp2 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP5A Q16539 6 352 360.0 52P:401,I46:402,I46:403 Type1,Allosteric,Allosteric Inactive DFGin 6.4998 14.3567 None -122.62, 154.65 81.43, 43.95 -64.35, -69.27 340.23, 142.83 -47.68, 999.0 in-in in 8.692 Saltbr-in 3.0371 HRD-in -62.14, -57.25 84.4, -19.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, -175.23 APE9-dihe-na -178.51, 127.74 APE8-dihe-out -56.55, -39.12 APE8-rot-none 999.0 APE67-dihe-in -64.7, -27.21 -46.07, -42.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3903 None None None XRAY 2.3 0.217 0.262 A 360.0 330.0 17 25 13 12 [[24, 308]] 1.0 3hp5 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK6 MK06_HUMAN 7AQBB Q16659 21 320 721.0 No_ligand No_ligand Inactive DFGin 6.3975 15.2127 None -131.48, -173.72 49.63, 73.98 -75.43, 999.0 277.2, 75.11 999.0, 999.0 out-none out 12.9244 Saltbr-none 999.0 HRD-in -76.36, -53.27 81.32, -12.25 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.52, -6.95 APE9-dihe-na -95.53, 119.94 APE8-dihe-in -80.87, 140.54 APE8-rot-out 180.68 APE67-dihe-in -60.55, -29.29 -99.38, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8091 None None None XRAY 2.25 0.224 0.258 B 320.0 274.0 27 31 17 14 [[20, 316]] 1.0 7aqb CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
CMGC MAPK7 MK07_HUMAN 4IC8A Q13164 40 390 816.0 No_ligand No_ligand Inactive DFGin 5.4362 14.9236 None -92.06, 155.45 51.19, -153.45 -171.08, -173.86 273.57, 105.49 -73.94, 141.79 in-out in 9.7832 Saltbr-out 3.9015 HRD-in -66.31, -37.46 67.28, -17.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na 64.3, -2.13 APE9-dihe-na -71.09, -179.85 APE8-dihe-in -118.59, 110.66 APE8-rot-in 294.15 APE67-dihe-out -100.15, -5.62 -130.02, 108.17 APE12-dist-in 13.8803 APE11-dist-out 14.0558 APE10-dist-out 18.6204 APE9-dist-out 13.2249 None None None XRAY 2.8 0.263 0.29 A 442.0 325.0 24 32 17 15 [[55, 347]] 1.0 4ic8 CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4IC8B Q13164 40 390 816.0 No_ligand No_ligand Inactive DFGin 6.3969 15.7622 None -93.15, 161.89 52.34, -151.75 -177.28, -172.69 263.71, 153.81 -56.07, 155.03 in-in in 9.7608 Saltbr-in 3.5023 HRD-in -80.21, -37.81 76.39, -22.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 67.32, -2.67 APE9-dihe-na -66.25, 157.12 APE8-dihe-in -110.21, 121.63 APE8-rot-in 263.54 APE67-dihe-out -97.54, -5.11 -133.15, 111.81 APE12-dist-out 14.5327 APE11-dist-out 14.7248 APE10-dist-out 19.5299 APE9-dist-out 13.6935 None None None XRAY 2.8 0.263 0.29 B 442.0 336.0 15 32 17 15 [[55, 347]] 1.0 4ic8 CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 9LTAB Q13164 50 393 816.0 A1EKR:401 Type1 Inactive DFGin 6.7132 16.0319 None -133.43, -159.55 65.18, -109.2 88.58, 2.31 289.32, 97.82 -50.15, -33.97 in-out in 9.903 Saltbr-out 4.1905 HRD-in -74.24, -46.7 76.49, -19.02 out-in-out SNCoio in-out ActLoopNT-in 3.0531 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -98.86, 114.14 APE9-dihe-na 64.16, 0.87 APE8-dihe-out -99.06, 1.52 APE8-rot-out 36.89 APE67-dihe-in -62.91, -30.4 -78.64, -10.21 APE12-dist-in 11.2468 APE11-dist-in 10.5167 APE10-dist-out 13.6196 APE9-dist-out 11.7225 None None None XRAY 2.33 0.252 0.292 B 346.0 342.0 2 32 32 0 [[55, 347]] 1.0 9lta CMGC_MAPK7_HUMAN CMGC 4.3e-81 278.5 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK8 MK08_HUMAN 4UX9B P45983 8 362 427.0 ANP:1000 ATPlike Inactive DFGin 6.8269 14.0009 None -95.23, -79.97 -82.17, 124.02 -113.22, 13.68 297.81, 107.19 -60.29, -32.64 in-in in 8.6029 Saltbr-in 2.9418 HRD-in -59.44, -53.0 79.08, -24.85 in-in-in SNCiii in-in ActLoopNT-in 2.5822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.47, -40.48 APE9-dihe-na -78.17, 138.93 APE8-dihe-in -64.59, 122.35 APE8-rot-in 308.57 APE67-dihe-in -67.83, -19.56 -32.59, -57.13 APE12-dist-in 12.3608 APE11-dist-in 12.1486 APE10-dist-in 6.5271 APE9-dist-in 4.6911 None None None XRAY 2.34 0.202 0.24 B 364.0 327.0 14 27 21 6 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2G01B P45983 9 364 427.0 73Q:61001 Type1 Inactive DFGin 5.7329 14.7118 None -124.05, -159.93 70.3, -99.04 78.28, -8.58 269.85, 26.32 -60.64, -29.84 in-in in 9.3096 Saltbr-in 3.522 HRD-in -75.33, -51.61 81.6, -31.16 in-in-out SNCiio in-out ActLoopNT-in 3.0497 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -55.32, -77.05 APE9-dihe-na -50.72, 131.97 APE8-dihe-in -62.41, 127.97 APE8-rot-out 179.45 APE67-dihe-in -34.47, -20.37 -26.15, -85.34 APE12-dist-in 12.6428 APE11-dist-in 12.8438 APE10-dist-in 7.3262 APE9-dist-in 4.7568 T183E,Y185E None None XRAY 3.5 0.296 0.354 B 370.0 356.0 0 27 27 0 [[26, 321]] 1.0 2g01 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2GMXB P45983 7 364 427.0 877:61001 Type1 Inactive DFGin 5.6113 13.9429 None -106.95, -175.57 54.48, -113.25 110.31, -6.6 279.44, 165.75 -41.3, -39.48 in-out in 8.4562 Saltbr-out 4.4993 HRD-in -77.53, -48.43 77.05, -21.57 out-in-in SNCoii in-in ActLoopNT-in 2.8017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.75, -77.84 APE9-dihe-na -45.43, 98.08 APE8-dihe-in -37.04, 123.81 APE8-rot-in 354.32 APE67-dihe-in -25.17, -38.2 -26.5, -90.08 APE12-dist-in 11.7738 APE11-dist-in 12.5874 APE10-dist-in 7.2474 APE9-dist-in 4.4727 T183E,Y185E None None XRAY 3.5 0.278 0.351 B 370.0 358.0 0 27 27 0 [[26, 321]] 1.0 2gmx CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK9 MK09_HUMAN 7CMLA P45984 1 364 424.0 No_ligand No_ligand Inactive DFGin 4.7496 14.8247 None -87.28, -45.52 -108.01, 154.81 -155.1, 45.31 47.34, 102.79 85.29, 999.0 in-in in 9.0823 Saltbr-in 2.8348 HRD-in -65.79, -57.36 78.71, -13.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 167.69 APE8-rot-out 53.66 APE67-dihe-in -63.3, -29.48 -74.93, -11.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A None None XRAY 2.15 0.286 0.327 A 381.0 334.0 24 27 11 16 [[26, 321]] 1.0 7cml CMGC_MAPK9_HUMAN CMGC 9.6e-84 287.1 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 7CMLB P45984 1 364 424.0 No_ligand No_ligand Inactive DFGin 4.7435 14.823 None -88.87, -45.55 -106.26, 153.92 -155.16, 45.33 47.81, 103.41 83.93, 999.0 in-in in 9.0777 Saltbr-in 2.8931 HRD-in -64.4, -56.23 76.1, -8.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 170.08 APE8-rot-out 54.21 APE67-dihe-in -61.48, -28.24 -72.46, -14.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A None None XRAY 2.15 0.286 0.327 B 381.0 335.0 23 27 11 16 [[26, 321]] 1.0 7cml CMGC_MAPK9_HUMAN CMGC 9.6e-84 287.1 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
NEK NEK2 NEK2_HUMAN 2XKDA P51955 3 271 445.0 T3M:61280 Type1 Inactive DFGin 7.7821 14.7211 None -118.6, -157.91 42.92, 77.2 -104.57, 999.0 308.02, 95.14 999.0, 999.0 out-out out 12.5186 Saltbr-out 9.1741 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 73.57, -54.62 APE9-dihe-na -57.09, 148.53 APE8-dihe-in -95.98, 122.75 APE8-rot-in 312.67 APE67-dihe-out -54.02, -37.1 -77.53, 67.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.183 0.217 A 279.0 243.0 26 28 14 14 [[8, 271]] 1.0 2xkd NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XKEA P51955 3 271 445.0 WI2:61280 Type1 Inactive DFGin 7.7802 14.674 None -126.61, -154.27 59.66, -98.99 82.09, 999.0 300.47, 105.7 999.0, 999.0 out-out out 12.1546 Saltbr-out 8.5597 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 108.7 APE8-rot-in 350.6 APE67-dihe-out -48.98, -38.02 -83.19, 66.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.203 0.178 0.226 A 279.0 235.0 34 28 10 18 [[8, 271]] 1.0 2xke NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XKFA P51955 3 271 445.0 BX1:61280 Type1 Inactive DFGin 8.0242 14.7934 None -136.65, 176.84 62.75, 83.47 -107.53, 999.0 295.67, 92.44 999.0, 999.0 out-out out 12.0968 Saltbr-out 8.6686 HRD-none 999.0, 999.0 999.0, -165.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -96.76, -179.12 APE9-dihe-na 106.62, 145.4 APE8-dihe-in -83.33, 139.63 APE8-rot-out 49.39 APE67-dihe-out -45.16, -35.54 -81.58, 70.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.8549 None None None XRAY 2.35 0.174 0.222 A 279.0 242.0 27 28 13 15 [[8, 271]] 1.0 2xkf NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 5M51A P51955 3 271 445.0 NU6:60301 Type1 Inactive DFGin 6.9172 15.0332 None -135.97, -170.98 47.05, 66.56 -67.3, 999.0 280.24, 65.86 999.0, 999.0 out-none out 13.3278 Saltbr-none 999.0 HRD-in -68.55, -48.07 77.08, -5.68 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, -15.98 APE9-dihe-na -61.81, 166.03 APE8-dihe-in -100.33, 135.8 APE8-rot-out 177.14 APE67-dihe-out -48.68, -33.32 -89.41, 73.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.1497 None None None XRAY 1.899 0.224 0.257 A 279.0 253.0 16 28 12 16 [[8, 271]] 1.0 5m51 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 5M57A P51955 3 271 445.0 4SP:60301 Type1 Inactive DFGin 6.8566 14.9053 None -135.46, -174.37 50.79, 73.32 -79.95, 999.0 289.86, 69.03 999.0, 999.0 out-none out 13.1668 Saltbr-none 999.0 HRD-in -67.32, -45.79 72.98, 0.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, -18.35 APE9-dihe-na -78.84, 166.93 APE8-dihe-in -97.45, 140.37 APE8-rot-out 196.13 APE67-dihe-out -44.71, -40.0 -94.19, 69.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.2658 None None None XRAY 2.3 0.221 0.274 A 279.0 253.0 16 28 12 16 [[8, 271]] 1.0 5m57 NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 9NFQC Q8TDX7 20 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.3069 11.9804 None -150.16, -164.53 74.32, -54.68 63.51, 118.45 304.42, 170.07 -50.32, 115.41 out-out out 14.52 Saltbr-out 10.4482 HRD-in -75.46, -45.69 71.31, -4.13 out-out-out SNCooo out-out ActLoopNT-out 9.1773 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.74, 126.83 APE9-dihe-na 80.61, 29.64 APE8-dihe-in -127.17, 154.0 APE8-rot-out 66.52 APE67-dihe-out -56.05, -43.39 -68.04, 167.92 APE12-dist-out 15.571 APE11-dist-out 14.5314 APE10-dist-out 11.8253 APE9-dist-out 8.4872 None None None XRAY 3.25 0.214 0.261 C 304.0 281.0 0 28 28 0 [[34, 294]] 1.0 9nfq NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQNA Q8TDX7 21 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.3657 14.509 None -71.0, 173.16 -64.84, 135.91 -62.15, 999.0 305.22, 52.49 999.0, 999.0 out-out out 14.0336 Saltbr-out 12.9475 HRD-in -74.75, -50.15 86.13, -19.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.46 APE8-rot-none 999.0 APE67-dihe-out -63.25, -48.51 -54.4, 143.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.192 0.221 A 310.0 259.0 21 28 10 18 [[34, 294]] 1.0 2wqn NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4K Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7265 12.7016 None -76.42, 178.47 -68.48, 131.61 -71.46, 136.2 73.57, 100.38 -72.87, 999.0 out-none out 15.6456 Saltbr-none 999.0 HRD-out -85.33, 115.72 -60.76, -44.72 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.68 APE8-rot-in 320.17 APE67-dihe-out -62.46, -41.14 -76.28, 170.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 K 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4L Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7281 12.7014 None -76.4, 178.58 -68.63, 131.64 -71.57, 136.19 73.61, 100.3 -72.85, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.34, 115.69 -60.77, -44.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.69 APE8-rot-in 320.25 APE67-dihe-out -62.33, -41.29 -76.38, 170.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 L 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4M Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7275 12.7029 None -76.4, 178.51 -68.6, 131.68 -71.51, 136.18 73.59, 100.26 -72.74, 999.0 out-none out 15.6446 Saltbr-none 999.0 HRD-out -85.42, 115.71 -60.74, -44.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.73 APE8-rot-in 320.25 APE67-dihe-out -62.39, -41.25 -76.39, 170.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 M 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4N Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7275 12.7015 None -76.43, 178.48 -68.52, 131.6 -71.44, 136.14 73.59, 100.37 -72.79, 999.0 out-none out 15.6461 Saltbr-none 999.0 HRD-out -85.34, 115.77 -60.86, -44.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.75 APE8-rot-in 320.35 APE67-dihe-out -62.31, -41.37 -76.45, 170.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 N 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4O Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7269 12.7018 None -76.34, 178.47 -68.49, 131.55 -71.34, 136.17 73.67, 100.39 -72.81, 999.0 out-none out 15.6437 Saltbr-none 999.0 HRD-out -85.31, 115.68 -60.76, -44.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.77 APE8-rot-in 320.21 APE67-dihe-out -62.36, -41.36 -76.32, 170.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 O 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4P Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7286 12.7018 None -76.31, 178.45 -68.55, 131.56 -71.36, 136.2 73.73, 100.23 -72.8, 999.0 out-none out 15.6453 Saltbr-none 999.0 HRD-out -85.31, 115.58 -60.59, -44.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.71 APE8-rot-in 320.25 APE67-dihe-out -62.34, -41.31 -76.37, 170.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 P 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4Q Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7278 12.7013 None -76.49, 178.43 -68.49, 131.55 -71.33, 136.21 73.64, 100.4 -72.85, 999.0 out-none out 15.6442 Saltbr-none 999.0 HRD-out -85.44, 115.71 -60.71, -44.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.79 APE8-rot-in 320.09 APE67-dihe-out -62.41, -41.17 -76.39, 170.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 Q 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4R Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7276 12.7013 None -76.4, 178.44 -68.5, 131.69 -71.51, 136.22 73.62, 100.38 -72.88, 999.0 out-none out 15.6433 Saltbr-none 999.0 HRD-out -85.44, 115.7 -60.7, -44.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.78 APE8-rot-in 320.16 APE67-dihe-out -62.38, -41.22 -76.37, 170.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 R 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4S Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7288 12.7035 None -76.31, 178.32 -68.42, 131.55 -71.49, 136.23 73.63, 100.27 -72.77, 999.0 out-none out 15.6452 Saltbr-none 999.0 HRD-out -85.28, 115.69 -60.57, -45.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.74 APE8-rot-in 320.25 APE67-dihe-out -62.31, -41.25 -76.38, 170.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 S 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4T Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7275 12.7017 None -76.48, 178.46 -68.52, 131.53 -71.34, 136.16 73.66, 100.37 -72.83, 999.0 out-none out 15.6448 Saltbr-none 999.0 HRD-out -85.37, 115.71 -60.75, -44.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.75 APE8-rot-in 320.16 APE67-dihe-out -62.36, -41.21 -76.33, 170.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 T 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQMA Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 7.3462 13.7783 None -83.18, 179.58 -74.59, 155.64 -97.08, 999.0 302.48, 61.21 999.0, 999.0 out-out out 13.9573 Saltbr-out 15.2417 HRD-in -76.69, -51.78 83.33, -13.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 71.1 APE8-rot-none 999.0 APE67-dihe-out -59.91, -51.02 -52.53, 142.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.175 0.215 A 310.0 258.0 23 28 10 18 [[34, 294]] 1.0 2wqm NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S76B Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 10.751 13.109 None -166.45, -175.9 66.54, -60.08 52.94, 60.47 203.88, 147.31 -68.33, 173.75 out-none out 14.9478 Saltbr-none 999.0 HRD-in -70.18, -57.7 76.2, 16.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnoo APE10-dihe-na 999.0, 48.62 APE9-dihe-na -59.14, -24.85 APE8-dihe-in -73.32, 170.94 APE8-rot-none 999.0 APE67-dihe-out -57.66, -44.72 -55.45, 165.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.6367 APE9-dist-out 12.9921 None None None XRAY 3.38 0.263 0.286 B 310.0 267.0 14 28 14 14 [[34, 294]] 1.0 6s76 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S76C Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 8.5831 12.7693 None -80.45, -160.94 -77.29, 134.54 -77.74, 135.51 80.77, 94.75 -93.77, 999.0 out-none out 15.9432 Saltbr-none 999.0 HRD-out -62.26, 96.66 -62.75, -12.92 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.78 APE8-rot-out 166.56 APE67-dihe-out -62.39, -38.88 -77.41, 171.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.38 0.263 0.286 C 310.0 264.0 17 28 11 17 [[34, 294]] 1.0 6s76 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73A Q8TDX7 21 300 302.0 F9N:401 Type1 Inactive DFGin 5.0528 16.3633 None -130.23, -159.39 -58.38, 166.65 -79.47, 179.09 272.7, 63.92 -73.82, 153.18 out-none out 12.5186 Saltbr-none 999.0 HRD-in -67.13, -43.16 71.04, 8.92 none-out-out SNCnoo out-out ActLoopNT-out 13.5886 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -68.95, 142.63 APE9-dihe-na -130.01, 150.44 APE8-dihe-in -121.46, 109.43 APE8-rot-in 306.53 APE67-dihe-out -37.47, -40.83 -62.79, 124.97 APE12-dist-none 999.0 APE11-dist-out 15.4448 APE10-dist-out 16.3422 APE9-dist-out 13.3404 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 A 310.0 269.0 11 28 17 11 [[34, 294]] 1.0 6s73 NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73B Q8TDX7 20 300 302.0 F9N:401 Type1 Inactive DFGin 4.0811 13.9355 None -178.99, -162.49 51.26, 73.22 -85.88, 62.38 41.39, 63.66 -85.37, 89.52 out-out out 12.5852 Saltbr-out 10.3655 HRD-in -66.25, -45.52 76.82, -13.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 162.68 APE9-dihe-na -69.13, -43.33 APE8-dihe-in -76.26, 166.14 APE8-rot-out 72.57 APE67-dihe-out -54.8, -43.78 -51.06, 164.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.7047 APE9-dist-out 14.4116 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 B 310.0 268.0 13 28 15 13 [[34, 294]] 1.0 6s73 NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73C Q8TDX7 26 300 302.0 F9N:401 Type1 Inactive DFGin 5.1386 15.7119 None 175.05, 74.28 -158.3, 138.44 -107.91, 105.5 333.64, 111.47 -61.5, -31.06 out-none out 13.7395 Saltbr-none 999.0 HRD-in -76.21, -36.25 71.18, -6.76 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.69 APE8-rot-in 301.01 APE67-dihe-out -51.09, -38.47 -89.97, 146.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 C 310.0 259.0 16 28 12 16 [[34, 294]] 1.0 6s73 NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S75B Q8TDX7 20 300 302.0 F9N:401 Type1 Inactive DFGin 7.4128 13.763 None -73.24, -152.21 -93.79, 137.64 -65.56, 124.67 301.05, 76.91 -140.58, 68.85 out-none out 15.5675 Saltbr-none 999.0 HRD-out -97.46, 106.21 -102.94, 24.07 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 46.75 APE8-dihe-in -82.12, 132.19 APE8-rot-none 999.0 APE67-dihe-out 55.67, -108.68 -80.05, 59.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8172 None None None XRAY 3.3 0.263 0.317 B 310.0 267.0 14 28 14 14 [[34, 294]] 1.0 6s75 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S75C Q8TDX7 22 300 302.0 F9N:401 Type1 Inactive DFGin 7.9029 12.9937 None -83.1, -140.31 -120.94, 14.53 61.24, -160.83 311.61, 103.49 -179.49, 170.79 out-none out 16.2627 Saltbr-none 999.0 HRD-in -77.1, -41.1 71.89, -12.02 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 68.43 APE8-rot-in 309.88 APE67-dihe-out -56.73, -49.48 -77.1, 161.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.263 0.317 C 310.0 263.0 16 28 12 16 [[34, 294]] 1.0 6s75 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
OTHER EIF2AK2 E2AK2_HUMAN 6D3LA P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.4282 13.5478 None -156.44, 50.2 -150.13, 79.38 -93.22, 34.5 307.79, 100.69 -75.1, -22.66 in-out in 8.2504 Saltbr-out 4.2085 HRD-out -109.72, 76.87 -49.41, -33.81 out-in-none SNCoin in-none ActLoopNT-in 2.8933 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.263 0.347 A 323.0 248.0 36 27 10 17 [[175, 537]] 1.0 6d3l OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUA P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.6173 12.2243 None 179.67, 47.65 -88.7, 86.35 -91.15, -3.67 303.64, 112.16 -78.11, 27.75 in-none in 8.5398 Saltbr-none 999.0 HRD-out -82.64, 83.35 -71.69, 48.72 none-in-out SNCnio in-out ActLoopNT-in 2.9471 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.49 APE8-rot-none 999.0 APE67-dihe-out -150.85, -147.51 -45.22, 110.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 A 306.0 255.0 33 27 16 11 [[175, 537]] 1.0 3uiu OTHER_EIF2AK2_HUMAN OTHER 3.3e-48 170.6 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUB P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.6133 12.222 None 179.62, 47.59 -88.43, 86.11 -90.92, -3.17 303.82, 112.2 -78.41, 27.48 in-none in 8.5339 Saltbr-none 999.0 HRD-out -82.77, 83.49 -72.08, 48.76 none-in-out SNCnio in-out ActLoopNT-in 2.9495 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.65 APE8-rot-none 999.0 APE67-dihe-out -150.91, -147.37 -45.27, 110.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 B 306.0 255.0 33 27 16 11 [[175, 537]] 1.0 3uiu OTHER_EIF2AK2_HUMAN OTHER 3.3e-48 170.6 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK3 E2AK3_HUMAN 4X7OA Q9NZJ5 585 1081 1116.0 3Z6:1101 Type1 Inactive DFGin 6.3414 13.6426 None -94.22, -155.12 -53.25, 136.69 -155.12, 166.24 66.84, 102.95 73.29, 999.0 out-out out 12.5237 Saltbr-out 8.5689 HRD-in -83.31, -58.9 75.59, 7.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.73 APE8-rot-out 177.5 APE67-dihe-in -54.31, -34.32 -114.42, 10.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.65 0.2 0.226 A 317.0 246.0 46 40 11 29 [[593, 1077]] 1.0 4x7o OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 7MF0AAA Q9NZJ5 586 1080 1116.0 Z6P:61101 Type1 Inactive DFGin 6.0948 13.7835 None -77.51, -156.87 -60.47, 147.45 -172.68, 155.23 76.53, 99.05 77.56, 168.51 out-out out 12.7278 Saltbr-out 8.739 HRD-in -96.15, -47.28 50.09, 33.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.24 APE8-rot-out 176.88 APE67-dihe-in -78.52, -21.92 -131.22, 23.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.809 0.234 0.273 AAA 317.0 259.0 31 40 13 27 [[593, 1077]] 1.0 7mf0 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQ9AAA Q9NZJ5 585 1080 1116.0 WPB:1101 Type1 Inactive DFGin 6.336 13.3424 None -89.55, -152.51 -63.21, 140.56 -148.5, 177.54 60.71, 99.01 64.9, 170.78 out-out out 12.6992 Saltbr-out 8.372 HRD-in -76.32, -70.44 74.66, 17.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 156.68 APE8-rot-out 169.43 APE67-dihe-in -67.45, -23.48 -135.96, 8.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.86 0.241 0.277 AAA 317.0 253.0 38 40 13 27 [[593, 1077]] 1.0 8eq9 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQDAAA Q9NZJ5 585 1080 1116.0 WPX:1101 Type1 Inactive DFGin 6.5107 13.3932 None -76.6, -162.05 -50.39, 140.83 -163.18, 172.47 74.08, 87.8 62.7, 177.79 out-out out 12.9537 Saltbr-out 8.0923 HRD-in -67.23, -62.02 65.5, 23.69 out-out-out SNCooo out-out ActLoopNT-out 11.8159 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.26 APE8-rot-out 186.47 APE67-dihe-in -80.59, -35.16 -113.72, 25.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.92 0.248 0.28 AAA 317.0 256.0 35 40 15 25 [[593, 1077]] 1.0 8eqd OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G31A Q9NZJ5 588 1080 1116.0 0WH:61102 Type1.5_Back Inactive DFGin 6.2319 13.8316 None -84.54, -159.02 -56.0, 133.56 -155.02, 170.5 66.17, 105.5 78.35, 175.83 out-out out 13.0614 Saltbr-out 9.6996 HRD-in -87.72, -55.13 80.73, -18.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.1 APE8-dihe-in -65.54, 146.89 APE8-rot-out 180.58 APE67-dihe-in -54.55, -32.6 -106.33, 6.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3041 None None None XRAY 2.28 0.205 0.242 A 299.0 247.0 38 40 14 26 [[593, 1077]] 1.0 4g31 OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G34A Q9NZJ5 588 1079 1116.0 924:61101 Type1.5_Back Inactive DFGin 6.097 13.6797 None -82.87, -161.08 -56.81, 138.38 -162.6, 172.39 72.3, 101.28 108.73, -50.4 out-out out 12.6916 Saltbr-out 9.7672 HRD-in -88.56, -52.58 79.71, -18.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.81 APE8-dihe-in -70.71, 157.12 APE8-rot-out 46.57 APE67-dihe-in -60.9, -30.41 -107.3, 13.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2436 None None None XRAY 2.7 0.21 0.258 A 299.0 247.0 37 40 13 27 [[593, 1077]] 1.0 4g34 OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4M7IA Q9NZJ5 588 1080 1116.0 27D:61101 Type1.5_Back Inactive DFGin 6.0292 13.826 None -84.66, -156.85 -61.94, 137.1 -158.49, 171.52 68.59, 102.9 119.66, -36.59 out-out out 12.7894 Saltbr-out 10.7583 HRD-in -87.5, -55.06 77.0, -17.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.52 APE8-dihe-in -64.41, 144.81 APE8-rot-out 183.67 APE67-dihe-in -62.47, -30.87 -109.76, 13.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1349 None None None XRAY 2.34 0.209 0.282 A 299.0 246.0 39 40 14 26 [[593, 1077]] 1.0 4m7i OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQEAAA Q9NZJ5 585 1080 1116.0 WQ2:1101 Type1.5_Back Inactive DFGin 6.2009 13.869 None -81.55, -152.92 -57.14, 146.2 -169.63, 166.16 75.82, 96.97 68.96, 171.99 out-out out 13.2313 Saltbr-out 9.1534 HRD-in -75.93, -57.84 73.17, 14.99 out-out-out SNCooo out-out ActLoopNT-out 12.8182 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.43 APE8-rot-out 173.87 APE67-dihe-in -71.31, -21.9 -114.54, 9.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.559 0.227 0.287 AAA 317.0 256.0 35 40 14 26 [[593, 1077]] 1.0 8eqe OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6A Q9P2K8 584 1004 1649.0 38O:1701 Type1 Inactive DFGin 4.5453 13.8322 None -64.42, 179.79 -78.36, -177.52 -104.81, 135.74 11.85, 74.61 -87.56, 999.0 out-out out 10.4039 Saltbr-out 7.2276 HRD-in -78.55, -45.81 67.95, -11.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -139.37, 156.89 APE9-dihe-na 68.88, -136.49 APE8-dihe-out -63.0, -22.3 APE8-rot-out 54.98 APE67-dihe-in -64.33, -22.31 -64.88, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3092 D848N None None XRAY 2.8 0.213 0.258 A 320.0 269.0 26 46 26 20 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6B Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.7434 14.4365 None -62.22, 177.25 -71.17, -177.31 -113.77, 112.84 16.57, 83.07 -117.04, 75.83 out-out out 10.6295 Saltbr-out 6.7733 HRD-in -73.84, -58.14 68.49, 11.03 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.51, 135.89 APE9-dihe-na 67.14, -114.96 APE8-dihe-out -68.69, -35.73 APE8-rot-out 40.19 APE67-dihe-in -61.7, -18.1 -60.4, -26.4 APE12-dist-out 22.8084 APE11-dist-out 18.7912 APE10-dist-out 18.981 APE9-dist-out 12.6461 D848N None None XRAY 2.8 0.213 0.258 B 320.0 275.0 22 46 28 18 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6C Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 5.1533 15.3312 None -67.88, 178.26 -74.84, 168.69 -62.36, -56.97 309.72, 121.46 57.54, 31.05 out-out out 10.4307 Saltbr-out 6.7866 HRD-in -71.08, -48.65 67.11, -5.82 out-out-out SNCooo out-out ActLoopNT-out 7.7299 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.35 APE8-dihe-out -115.25, -20.91 APE8-rot-out 51.72 APE67-dihe-in -84.71, -19.81 -111.62, 33.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7921 D848N None None XRAY 2.8 0.213 0.258 C 320.0 267.0 30 46 17 29 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6D Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.7934 14.7823 None -71.0, 172.41 -73.73, 163.04 -66.19, -82.98 327.33, 91.13 74.54, 67.6 out-out out 11.1023 Saltbr-out 6.778 HRD-in -68.97, -46.58 79.03, -46.68 out-out-none SNCoon out-none ActLoopNT-out 6.5052 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.25, -17.58 999.0, -55.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.8 0.213 0.258 D 320.0 260.0 37 46 17 29 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER ERN1 ERN1_HUMAN 4Z7GA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 4.9957 14.5333 None -140.81, 175.34 43.48, 101.03 -87.72, 999.0 308.92, 94.22 999.0, 999.0 in-in in 8.9466 Saltbr-in 2.8404 HRD-in -60.57, -47.56 72.24, -10.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, -18.99 APE9-dihe-na -167.3, -173.38 APE8-dihe-in -130.49, 124.62 APE8-rot-out 52.96 APE67-dihe-inflip 106.42, -11.92 -35.23, 118.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8338 None None None XRAY 2.6 0.204 0.226 A 416.0 366.0 26 31 12 19 [[571, 832]] 1.0 4z7g OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7GB O75460 562 962 977.0 No_ligand No_ligand Inactive DFGin 4.9099 14.386 None -141.89, 174.99 45.35, 92.04 -84.88, 999.0 313.4, 110.77 999.0, 999.0 in-in in 8.916 Saltbr-in 2.8322 HRD-in -60.96, -47.53 72.73, -11.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -63.92, -20.1 APE9-dihe-na -168.1, 175.6 APE8-dihe-in -122.17, 125.73 APE8-rot-out 53.21 APE67-dihe-inflip 110.25, -18.1 -36.38, 118.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8352 None None None XRAY 2.6 0.204 0.226 B 416.0 377.0 24 31 13 18 [[571, 832]] 1.0 4z7g OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7HA O75460 562 963 977.0 4L5:1001 Type1 Inactive DFGin 5.3928 14.9773 None -138.87, -45.43 -76.98, 88.77 -83.95, 3.75 273.49, 77.38 -61.03, -41.59 in-in in 8.8506 Saltbr-in 2.8087 HRD-in -73.17, -46.77 63.73, 3.56 in-in-out SNCiio in-out ActLoopNT-in 2.9283 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -6.85 APE9-dihe-na 151.6, -155.97 APE8-dihe-in -123.5, 123.79 APE8-rot-out 45.5 APE67-dihe-inflip 106.26, -20.23 -56.36, 141.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6127 APE9-dist-in 4.6464 None None None XRAY 2.9 0.202 0.225 A 416.0 385.0 10 31 26 5 [[571, 832]] 1.0 4z7h OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER HASPIN HASP_HUMAN 9B2TK Q8TF76 470 798 798.0 No_ligand No_ligand Inactive DFGin 10.4725 16.9979 None -74.01, 167.84 -68.22, 151.89 -112.4, 131.65 323.3, 85.18 -72.17, -31.47 out-out out 10.3713 Saltbr-out 8.7387 HRD-naN -90.05, -46.55 60.89, 17.99 out-in-na SNCoia in-na ActLoopNT-in 2.5087 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -99.75, 7.12 APE9-dihe-na -76.13, 178.32 APE8-dihe-na -157.85, 172.7 APE8-rot-na 78.9 APE67-dihe-na -161.94, 175.92 118.79, -26.14 APE12-dist-na 11.1904 APE11-dist-na 13.5351 APE10-dist-na 18.0641 APE9-dist-na 14.0274 None None None EM 2.99 999.0 999.0 K 357.0 329.0 0 35 35 0 [[484, 797]] 1.0 9b2t OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1.0 314.0 314.0 686 687 688 690 692 511 535 539 646 648 647 649.0 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER IKBKB IKKB_HUMAN 4E3CA O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.9293 12.5145 None -102.89, -152.86 -13.03, 129.81 -123.22, 17.82 259.81, 46.81 -50.25, -6.57 in-in in 8.4978 Saltbr-in 2.7367 HRD-in -75.26, -33.92 66.88, -70.59 in-in-out SNCiio in-out ActLoopNT-in 2.667 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na 54.47, 176.72 APE9-dihe-na 61.59, 168.61 APE8-dihe-out -55.76, -20.8 APE8-rot-out 96.27 APE67-dihe-out -19.53, -58.21 71.19, -31.91 APE12-dist-in 7.8908 APE11-dist-in 11.3832 APE10-dist-out 9.7094 APE9-dist-out 11.5196 S177E,S181E None None XRAY 3.98 0.267 0.299 A 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CE O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.9501 12.2838 None -103.98, -153.14 -13.07, 129.81 -119.97, 29.25 259.42, 48.55 -39.7, -60.66 in-in in 8.4922 Saltbr-in 2.789 HRD-in -74.27, -34.04 66.66, -69.45 in-in-out SNCiio in-out ActLoopNT-in 2.7665 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -137.36, 34.73 APE9-dihe-na -147.47, 29.61 APE8-dihe-out 50.03, 13.62 APE8-rot-out 70.79 APE67-dihe-out 72.17, -45.62 58.67, -106.57 APE12-dist-in 7.8793 APE11-dist-in 9.547 APE10-dist-out 9.1157 APE9-dist-out 10.7947 S177E,S181E None None XRAY 3.98 0.267 0.299 E 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER PINK1 PINK1_HUMAN 9EIHB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.6424 15.2899 None -150.1, 27.9 -151.22, 84.19 -78.07, 7.71 280.09, 73.93 -56.26, -25.65 in-in in 8.1541 Saltbr-in 2.8752 HRD-out -83.89, 74.38 -55.2, 147.76 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 129.6, 170.75 APE9-dihe-na -57.41, 126.81 APE8-dihe-in -63.88, 123.56 APE8-rot-na 292.08 APE67-dihe-out -68.62, -37.63 170.95, 170.71 APE12-dist-in 8.2649 APE11-dist-in 10.7013 APE10-dist-in 6.1781 APE9-dist-in 5.5107 None None None EM 3.1 999.0 999.0 B 603.0 443.0 76 34 34 0 [[149, 517]] 1.0 9eih OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1.0 371.0 371.0 383 384 385 387 389 219 240 244 359 361 360 362.0 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIIB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.5376 15.2684 None -148.12, 29.18 -150.34, 82.77 -78.44, 7.18 280.06, 75.46 -55.89, -31.96 in-in in 8.1906 Saltbr-in 2.6988 HRD-out -84.11, 73.3 -54.72, 147.35 in-in-out SNCiio in-out ActLoopNT-in 2.8909 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 126.48, 169.31 APE9-dihe-na -55.3, 129.37 APE8-dihe-in -64.28, 120.54 APE8-rot-na 293.88 APE67-dihe-out -69.11, -35.23 177.3, 167.48 APE12-dist-in 8.425 APE11-dist-in 10.6482 APE10-dist-in 6.0928 APE9-dist-in 5.5648 None None None EM 2.75 999.0 999.0 B 603.0 443.0 76 34 34 0 [[149, 517]] 1.0 9eii OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1.0 371.0 371.0 383 384 385 387 389 219 240 244 359 361 360 362.0 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIJB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.5773 15.6313 None -148.4, 28.85 -150.95, 82.12 -77.4, 7.45 279.57, 75.37 -55.31, -31.89 in-in in 8.3355 Saltbr-in 3.1731 HRD-out -83.93, 72.97 -54.61, 147.01 in-in-out SNCiio in-out ActLoopNT-in 2.7745 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 126.25, 168.92 APE9-dihe-na -55.5, 129.75 APE8-dihe-in -63.67, 120.0 APE8-rot-na 293.7 APE67-dihe-out -68.89, -34.96 176.76, 167.65 APE12-dist-in 8.2697 APE11-dist-in 10.7719 APE10-dist-in 6.249 APE9-dist-in 5.4487 None None None EM 3.3 999.0 999.0 B 603.0 443.0 76 34 34 0 [[149, 517]] 1.0 9eij OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1.0 371.0 371.0 383 384 385 387 389 219 240 244 359 361 360 362.0 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER TBK1 TBK1_HUMAN 6BNYA Q9UHD2 1 657 729.0 E0M:801 Type1 Inactive DFGin 6.8713 14.259 None -144.13, -26.45 -127.29, 108.83 -162.84, 152.36 47.44, 84.0 75.64, 999.0 out-out out 14.7547 Saltbr-out 12.9204 HRD-in -102.85, -58.68 62.76, -53.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.55 APE8-rot-in 310.76 APE67-dihe-in -67.57, -21.0 -66.63, -30.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.341 0.233 0.287 A 660.0 609.0 34 27 11 16 [[9, 625]] 1.0 6bny OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6BOEA Q9UHD2 1 657 729.0 E0S:60701 Type1 Inactive DFGin 6.9192 14.0337 None -140.29, -57.72 -92.01, 95.65 -150.11, 999.0 50.59, 85.3 999.0, 999.0 out-out out 14.2378 Saltbr-out 11.8956 HRD-in -100.51, -43.17 59.35, -67.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -167.84 APE8-dihe-in -93.97, 148.54 APE8-rot-in 317.28 APE67-dihe-in -97.0, -14.84 -58.66, -27.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.8984 None None None XRAY 3.598 0.246 0.291 A 660.0 599.0 46 27 11 16 [[9, 625]] 1.0 6boe OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ0A Q9UHD2 1 657 729.0 F8M:60801 Type1 Inactive DFGin 7.0583 14.1697 None -145.32, -48.95 -97.67, 99.43 -150.2, 69.66 41.19, 106.47 -153.94, 166.29 out-out out 14.6205 Saltbr-out 12.4927 HRD-in -82.5, -25.39 61.31, -62.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -74.47 APE8-dihe-in -121.62, 145.83 APE8-rot-in 316.01 APE67-dihe-in -80.24, -16.92 -66.55, -39.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0522 None None None XRAY 3.19 0.24 0.293 A 660.0 603.0 40 27 13 14 [[9, 625]] 1.0 6cq0 OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ4A Q9UHD2 1 657 729.0 F8P:60801 Type1 Inactive DFGin 6.9825 14.1972 None -148.33, -48.83 -93.41, 87.11 -146.09, 999.0 49.51, 84.45 999.0, 999.0 out-out out 14.5465 Saltbr-out 12.7304 HRD-in -82.2, -27.57 62.97, -55.42 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -72.21 APE8-dihe-in -126.99, 151.01 APE8-rot-in 318.15 APE67-dihe-in -74.77, -17.35 -67.05, -46.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7198 None None None XRAY 3.2 0.235 0.272 A 660.0 603.0 40 27 11 16 [[9, 625]] 1.0 6cq4 OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ5A Q9UHD2 1 657 729.0 F8S:60801 Type1 Inactive DFGin 6.7174 14.1788 None -145.73, -48.48 -97.16, 93.96 -153.08, 999.0 53.79, 88.24 999.0, 999.0 out-out out 14.6166 Saltbr-out 12.6396 HRD-in -85.7, -26.16 62.99, -56.36 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -79.38, -18.02 999.0, -39.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.354 0.233 0.275 A 660.0 601.0 42 27 9 18 [[9, 625]] 1.0 6cq5 OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSRA Q9UHD2 2 657 729.0 KHT:60900 Type1 Inactive DFGin 6.9965 13.9548 None -156.53, -62.85 -81.29, 81.31 -143.8, 159.0 54.44, 89.38 84.08, 8.25 out-out out 14.1172 Saltbr-out 11.9582 HRD-in -102.36, -69.73 73.33, -20.77 out-out-none SNCoon out-none ActLoopNT-out 8.0414 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.29 APE8-dihe-in -74.97, 146.4 APE8-rot-in 310.67 APE67-dihe-in -80.54, -16.93 -52.28, -36.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9152 None None None XRAY 3.15 0.282 0.307 A 663.0 625.0 22 27 17 10 [[9, 625]] 1.0 6rsr OTHER_TBK1_HUMAN OTHER 9.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSUA Q9UHD2 2 657 729.0 KJB:60701 Type1 Inactive DFGin 6.6376 14.1131 None -154.16, -13.81 -149.75, 80.99 -136.99, 156.49 58.38, 98.61 87.97, 3.83 out-out out 13.6649 Saltbr-out 10.5278 HRD-in -95.03, -62.14 77.79, -56.35 out-out-none SNCoon out-none ActLoopNT-out 8.3756 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.58 APE8-dihe-in -74.98, 144.67 APE8-rot-in 310.9 APE67-dihe-in -80.01, -17.92 -55.62, -36.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.4733 None None None XRAY 2.75 0.292 0.351 A 663.0 625.0 22 27 17 10 [[9, 625]] 1.0 6rsu OTHER_TBK1_HUMAN OTHER 9.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWPA Q9UHD2 2 657 729.0 BX7:60701 Type1 Inactive DFGin 7.288 13.4137 None -134.43, -56.21 -87.24, 102.18 -162.15, 172.63 51.08, 85.4 74.44, 12.62 out-out out 14.1533 Saltbr-out 13.3168 HRD-in -97.28, -65.46 67.49, -12.98 out-out-none SNCoon out-none ActLoopNT-out 7.8934 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.34 APE8-dihe-in -75.67, 146.05 APE8-rot-in 314.2 APE67-dihe-in -83.23, -17.66 -52.37, -34.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5598 S172A None None XRAY 3.065 0.283 0.335 A 659.0 625.0 22 27 17 10 [[9, 625]] 1.0 4iwp OTHER_TBK1_HUMAN OTHER 7.9e-42 149.7 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWQA Q9UHD2 2 657 729.0 1FV:60701 Type1 Inactive DFGin 6.9857 13.5395 None -151.26, -54.27 -82.9, 74.22 -133.51, 165.85 51.03, 84.3 72.58, 18.91 out-out out 13.6553 Saltbr-out 10.9779 HRD-in -91.75, -57.98 64.75, -44.39 out-out-none SNCoon out-none ActLoopNT-out 7.834 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.51 APE8-dihe-in -69.41, 148.35 APE8-rot-in 313.75 APE67-dihe-in -92.47, 5.0 -54.53, -34.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1357 S172A None None XRAY 3.0 0.264 0.31 A 659.0 623.0 22 27 17 10 [[9, 625]] 1.0 4iwq OTHER_TBK1_HUMAN OTHER 7.9e-42 149.7 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TTK TTK_HUMAN 7CHMA P33981 516 794 857.0 FZF:801 Type1 Inactive DFGin 4.4135 14.6083 None -111.88, -71.82 -63.89, 158.67 -119.5, 9.1 283.45, 179.72 82.92, -15.75 in-in in 9.5598 Saltbr-in 3.396 HRD-in -57.59, -51.23 60.31, 6.24 in-out-out SNCioo out-out ActLoopNT-out 12.2637 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -62.47 APE9-dihe-na 66.11, 172.68 APE8-dihe-out -121.28, -175.85 APE8-rot-none 999.0 APE67-dihe-in -54.56, -33.62 -132.81, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.8631 APE9-dist-out 12.904 None TPO675,TPO686 TPO675,TPO686 XRAY 2.65 0.212 0.253 A 281.0 260.0 19 30 22 8 [[525, 791]] 1.0 7chm OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER WNK1 WNK1_HUMAN 4PWNA Q9H4A3 210 482 2382.0 No_ligand No_ligand Inactive DFGin 7.0567 13.279 None -116.45, -167.58 52.85, 34.92 -53.76, -53.16 298.89, 177.5 -76.46, 5.08 out-na out 14.364 Saltbr-na 999.0 HRD-in -62.97, -49.68 71.0, -9.34 na-out-none SNCaon out-none ActLoopNT-out 7.5238 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 153.02 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.84 0.231 0.274 A 274.0 245.0 28 26 13 13 [[220, 479]] 1.0 4pwn OTHER_WNK1_HUMAN WNK 9e-179 598.1 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK3 WNK3_HUMAN 5O23A Q9BYP7 136 405 1800.0 No_ligand No_ligand Inactive DFGin 6.2673 15.7474 None -58.12, 150.75 -62.49, 153.69 -74.35, -24.44 301.07, 176.19 -64.82, -47.37 out-na out 15.5465 Saltbr-na 999.0 HRD-in -69.6, -49.52 69.26, 5.04 na-out-out SNCaoo out-out ActLoopNT-out 6.392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 18.0 APE9-dihe-na -73.23, 148.07 APE8-dihe-in -120.2, 82.68 APE8-rot-out 60.44 APE67-dihe-in -69.8, -9.43 -68.14, -14.79 APE12-dist-out 16.5812 APE11-dist-out 14.4317 APE10-dist-out 11.0908 APE9-dist-out 8.8043 None SEP304 SEP304 XRAY 2.25 0.207 0.239 A 285.0 270.0 0 26 26 0 [[146, 405]] 1.0 5o23 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1.0 260.0 260.0 293 294 295 297 299 176 194 198 272 274 273 275.0 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O23B Q9BYP7 132 408 1800.0 No_ligand No_ligand Inactive DFGin 5.9369 15.615 None -58.71, 149.58 -63.07, 151.65 -71.84, -20.45 305.92, 177.41 -66.4, -56.29 out-na out 16.0507 Saltbr-na 999.0 HRD-in -79.22, -48.18 69.94, -5.08 na-out-out SNCaoo out-out ActLoopNT-out 6.6174 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 20.94 APE9-dihe-na -70.16, 151.66 APE8-dihe-in -125.85, 83.91 APE8-rot-out 52.59 APE67-dihe-in -66.53, -19.04 -68.8, -9.41 APE12-dist-out 16.4092 APE11-dist-out 14.19 APE10-dist-out 10.9077 APE9-dist-out 8.4476 None SEP304 SEP304 XRAY 2.25 0.207 0.239 B 285.0 277.0 0 26 26 0 [[146, 405]] 1.0 5o23 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1.0 260.0 260.0 293 294 295 297 299 176 194 198 272 274 273 275.0 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
RGC NPR1 ANPRA_HUMAN 9BCSA P16066 503 1055 1061.0 ATP:61100 ATPlike Pseudo DFGin 7.6937 15.7366 None -74.51, -65.19 38.98, 36.73 -149.34, 137.28 313.08, 80.76 -109.19, -24.55 out-none out 17.3363 Saltbr-none 999.0 HRD-in -67.46, -13.34 80.4, -46.04 none-out-out SNCnoo out-out ActLoopNT-out 11.4528 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -59.39, -44.12 APE9-dihe-na -70.77, -47.95 APE8-dihe-out -62.03, -25.18 APE8-rot-na 74.24 APE67-dihe-in -57.49, -15.22 -74.7, -41.95 APE12-dist-out 24.0207 APE11-dist-out 19.7602 APE10-dist-out 23.1609 APE9-dist-out 13.3465 None None None EM 4.4 999.0 999.0 A 1040.0 515.0 23 28 28 0 [[539, 803]] 1.0 9bcs RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
STE MAP2K1 MP2K1_HUMAN 5YT3B Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.8963 14.534 None -102.15, -169.78 -40.15, 149.52 -75.91, 143.56 303.08, 84.8 -64.88, 94.03 out-out out 16.3586 Saltbr-out 14.8656 HRD-out -104.42, 23.77 -144.46, 111.13 out-out-out SNCooo out-out ActLoopNT-out 8.0209 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -80.58, -32.09 APE9-dihe-na -86.11, -15.83 APE8-dihe-out 58.15, 64.44 APE8-rot-in 310.76 APE67-dihe-out -122.56, 143.11 -138.66, 139.98 APE12-dist-out 19.0552 APE11-dist-out 14.0554 APE10-dist-out 18.8403 APE9-dist-out 25.9099 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 B 350.0 311.0 32 26 26 0 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7501 14.7176 None -77.53, 172.31 -71.81, 159.92 -66.82, 141.72 314.31, 87.77 -59.96, 135.61 out-out out 16.8715 Saltbr-out 15.0058 HRD-out -106.97, -11.01 -97.02, 107.72 out-out-out SNCooo out-out ActLoopNT-out 8.2442 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.82, -51.0 APE9-dihe-na -70.37, -13.35 APE8-dihe-out 47.35, 74.88 APE8-rot-out 143.99 APE67-dihe-out -134.73, 126.26 -143.64, 140.67 APE12-dist-out 19.3394 APE11-dist-out 14.3822 APE10-dist-out 19.1547 APE9-dist-out 26.1684 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 D 350.0 309.0 35 26 26 0 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8YP4A Q02750 34 384 393.0 WNT:401 Type1 Inactive DFGin 5.6499 12.5748 None -114.29, -33.59 -28.46, 108.03 -125.65, 141.38 278.55, 110.59 -62.12, 167.08 out-out out 15.0636 Saltbr-out 17.0816 HRD-out 70.59, -102.97 160.56, -67.88 out-out-out SNCooo out-out ActLoopNT-out 13.7522 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 77.83 APE9-dihe-na -121.62, 81.96 APE8-dihe-out 101.02, -24.75 APE8-rot-in 322.27 APE67-dihe-out -132.46, 136.61 -111.44, 133.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.1822 APE9-dist-out 15.9962 T286A,T292A,S298A None None XRAY 2.35 0.21 0.284 A 365.0 305.0 46 26 17 9 [[68, 361]] 1.0 8yp4 STE_MAP2K1_HUMAN STE 1.9e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K6 MP2K6_HUMAN 3ENMA P52564 46 332 334.0 No_ligand No_ligand Inactive DFGin 7.2057 11.561 None -72.54, 127.3 -73.54, -5.06 -145.36, 172.63 75.39, 93.79 -81.87, 71.68 out-na out 14.7786 Saltbr-na 19.7289 HRD-in -62.52, -52.47 78.76, -8.63 na-out-none SNCaon out-none ActLoopNT-out 14.8184 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.11, 104.97 999.0, -79.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 A 316.0 278.0 9 27 18 9 [[53, 314]] 1.0 3enm STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMB P52564 49 332 334.0 No_ligand No_ligand Inactive DFGin 6.4336 11.873 None -76.15, 120.81 -66.53, 1.54 -153.84, 168.39 61.21, 99.4 -71.06, 67.13 out-na out 15.0002 Saltbr-na 20.0247 HRD-in -64.57, -50.97 79.15, -4.28 na-out-none SNCaon out-none ActLoopNT-out 14.4809 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.08, 113.2 999.0, -108.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 B 316.0 271.0 13 27 19 8 [[53, 314]] 1.0 3enm STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMC P52564 48 332 334.0 No_ligand No_ligand Inactive DFGin 6.8007 11.7267 None -62.87, 122.88 -68.86, -8.42 -137.51, 177.55 64.57, 100.37 -78.87, 64.07 out-na out 14.8261 Saltbr-na 19.8254 HRD-in -65.29, -57.18 66.82, -2.67 na-out-none SNCaon out-none ActLoopNT-out 14.5147 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -82.6, 107.52 999.0, -65.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 C 316.0 274.0 11 27 19 8 [[53, 314]] 1.0 3enm STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMD P52564 45 332 334.0 No_ligand No_ligand Inactive DFGin 6.8746 11.4777 None -70.65, 125.17 -79.65, 11.99 -158.34, 166.38 66.09, 89.82 -77.06, 78.99 out-na out 14.5686 Saltbr-na 19.5439 HRD-in -56.29, -53.91 80.33, -16.21 na-out-none SNCaon out-none ActLoopNT-out 14.8567 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -80.61, 127.32 999.0, -136.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 D 316.0 279.0 9 27 18 9 [[53, 314]] 1.0 3enm STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K7 MP2K7_HUMAN 5B2MA O14733 105 400 419.0 No_ligand No_ligand Inactive DFGin 9.579 19.7731 None -127.86, 134.8 -161.61, -89.86 49.84, 999.0 177.0, 80.04 999.0, 999.0 out-na out 12.7097 Saltbr-na 12.8043 HRD-in -62.81, -53.51 71.04, 8.99 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 42.27 APE9-dihe-na -108.06, 130.67 APE8-dihe-out -63.3, -33.92 APE8-rot-na 122.97 APE67-dihe-in -63.12, -24.65 -98.4, 12.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8922 None None None XRAY 3.06 0.291 0.364 A 324.0 255.0 41 27 12 15 [[120, 380]] 1.0 5b2m STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVLA O14733 102 402 419.0 1XZ:60501 Type1 Inactive DFGin 4.9356 14.7119 None -131.83, 135.57 1.69, 124.27 -119.89, 81.31 23.68, 77.2 -67.86, -14.37 in-na in 9.3478 Saltbr-na 999.0 HRD-in -75.58, -48.66 66.23, 10.91 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 161.45 APE9-dihe-na -75.62, -169.03 APE8-dihe-in -66.96, 129.78 APE8-rot-na 196.63 APE67-dihe-in -77.35, -36.68 -69.13, -18.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6445 APE9-dist-in 3.4276 None None None XRAY 2.9 0.248 0.27 A 318.0 279.0 22 27 15 12 [[120, 380]] 1.0 7ovl STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVMA O14733 102 402 419.0 21I:60501 Type1 Inactive DFGin 5.5693 14.8886 None -100.36, -115.13 -133.81, 137.4 -113.6, 82.88 349.67, 74.13 -90.73, -9.2 in-na in 9.611 Saltbr-na 4.2453 HRD-in -65.68, -55.04 65.08, 15.11 na-in-none SNCain in-none ActLoopNT-in 2.9245 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.58 APE8-dihe-in -69.89, 133.33 APE8-rot-na 191.29 APE67-dihe-in -78.39, -27.08 -69.91, -12.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.3277 None None None XRAY 2.9 0.233 0.286 A 318.0 282.0 19 27 16 11 [[120, 380]] 1.0 7ovm STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVNA O14733 102 402 419.0 2I8:60501 Type1 Inactive DFGin 4.9662 14.684 None -79.07, -108.85 -132.92, 129.36 -118.94, 86.57 14.8, 59.14 -92.78, -9.46 in-na in 8.7495 Saltbr-na 3.314 HRD-in -73.42, -49.75 66.93, 12.16 na-in-out SNCaio in-out ActLoopNT-in 2.7697 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 179.48 APE9-dihe-na -73.36, -177.84 APE8-dihe-in -62.31, 134.27 APE8-rot-na 205.08 APE67-dihe-in -72.39, -30.0 -65.21, -22.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6301 APE9-dist-in 3.5925 None None None XRAY 2.9 0.225 0.257 A 318.0 283.0 18 27 17 10 [[120, 380]] 1.0 7ovn STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 9HZ0A O14733 101 401 419.0 A1IY7:60501 Type1 Inactive DFGin 5.7468 14.9744 None -112.81, -166.53 -54.75, 142.97 -115.5, 75.64 327.47, 81.17 -69.37, -28.6 in-na in 8.8354 Saltbr-na 999.0 HRD-in -68.14, -48.97 74.35, -1.92 na-in-none SNCain in-none ActLoopNT-in 2.9492 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.19 APE8-dihe-in -74.03, 132.92 APE8-rot-na 185.24 APE67-dihe-in -65.54, -21.82 -64.33, -35.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7967 None None None XRAY 2.25 0.223 0.263 A 318.0 278.0 23 27 15 12 [[120, 380]] 1.0 9hz0 STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVKA O14733 102 401 419.0 2I5:60502 Type1.5_Back Inactive DFGin 5.7986 14.1308 None -146.4, 162.27 58.41, 85.98 -92.37, 999.0 319.32, 113.16 999.0, 999.0 in-na in 9.452 Saltbr-na 7.5825 HRD-in -63.92, -73.21 74.68, -0.77 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.217 0.244 A 318.0 256.0 44 27 2 25 [[120, 380]] 1.0 7ovk STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6IB2A O14733 102 401 419.0 862:60501 Type1.5_Front Inactive DFGin 5.2764 14.0728 None -91.61, -76.02 -109.31, 164.08 -125.38, 999.0 315.5, 111.59 999.0, 999.0 in-na in 9.9266 Saltbr-na 8.3493 HRD-out -68.06, 100.79 -82.59, 24.57 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -28.73 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.224 0.25 A 318.0 265.0 35 27 8 19 [[120, 380]] 1.0 6ib2 STE_MAP2K7_HUMAN STE 3.1e-80 275.2 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP3K5 M3K5_HUMAN 5VIOC Q99683 670 940 1374.0 No_ligand No_ligand Inactive DFGin 6.3572 13.8249 None -118.22, -166.23 70.4, -83.21 71.44, -145.78 303.48, 97.0 79.63, -42.0 in-in in 8.3845 Saltbr-in 2.9481 HRD-in -67.24, -40.33 70.79, -6.68 in-in-out SNCiio in-out ActLoopNT-in 3.0199 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -146.22, 135.17 APE9-dihe-na -72.34, -160.36 APE8-dihe-in -65.61, 126.24 APE8-rot-in 312.24 APE67-dihe-in -64.54, -23.72 -53.71, -45.87 APE12-dist-in 10.9189 APE11-dist-out 5.8159 APE10-dist-out 9.8272 APE9-dist-in 3.9187 None None None XRAY 2.84 0.181 0.216 C 293.0 271.0 0 28 28 0 [[678, 938]] 1.0 5vio STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VILC Q99683 670 940 1374.0 9E1:4000 Type1 Inactive DFGin 6.6807 13.6651 None -127.14, -166.22 81.0, -82.49 64.22, -158.94 310.26, 99.86 83.75, -48.04 in-in in 8.3873 Saltbr-in 2.7669 HRD-in -62.04, -44.3 71.5, -5.97 in-in-out SNCiio in-out ActLoopNT-in 3.0012 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.26, 132.14 APE9-dihe-na -63.89, -152.16 APE8-dihe-in -75.62, 128.61 APE8-rot-in 305.72 APE67-dihe-in -63.56, -22.05 -54.79, -48.45 APE12-dist-in 10.7945 APE11-dist-out 5.8136 APE10-dist-out 9.964 APE9-dist-in 3.8263 None None None XRAY 2.64 0.182 0.213 C 293.0 271.0 0 28 28 0 [[678, 938]] 1.0 5vil STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 7KACA Q92918 7 304 833.0 W9D:401 Type1 Inactive DFGin 8.0218 14.8051 None -141.48, 167.09 66.93, 78.4 -88.8, 999.0 297.14, 96.79 999.0, 999.0 out-out out 12.7535 Saltbr-out 11.2541 HRD-in -70.03, -49.57 71.67, 0.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -89.52, 94.35 APE9-dihe-na 120.85, -175.69 APE8-dihe-in -107.35, 147.06 APE8-rot-out 190.1 APE67-dihe-in -53.56, -32.93 -92.41, -14.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.986 L221D,F225E None None XRAY 1.85 0.217 0.232 A 340.0 283.0 15 28 13 15 [[17, 274]] 1.0 7kac STE_MAP4K1_HUMAN STE 4.2e-91 310.8 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8DA Q92918 7 293 833.0 A1ITC:301 Type1 Inactive DFGin 4.6231 14.038 None -56.45, -37.26 -153.97, -176.48 -89.45, 20.13 56.87, 83.02 106.24, -162.07 out-out out 13.3927 Saltbr-out 11.4109 HRD-in -65.3, -52.29 59.62, 17.42 out-out-out SNCooo out-out ActLoopNT-out 6.9406 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -60.47, -36.02 APE9-dihe-na -87.07, -11.18 APE8-dihe-in -151.76, 75.87 APE8-rot-out 169.0 APE67-dihe-in -55.43, -30.79 -91.48, 7.95 APE12-dist-in 9.2894 APE11-dist-in 10.2065 APE10-dist-out 13.9989 APE9-dist-out 12.4548 T165E,S171E None None XRAY 1.641 0.199 0.226 A 294.0 287.0 0 28 28 0 [[17, 274]] 1.0 9h8d STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8EA Q92918 7 293 833.0 A1ITA:301 Type1 Inactive DFGin 4.8712 13.6432 None -54.93, -36.87 -153.52, -178.14 -86.71, 13.52 57.7, 54.93 110.72, -162.78 out-out out 13.2442 Saltbr-out 11.9403 HRD-in -64.82, -60.03 68.16, 15.68 out-out-out SNCooo out-out ActLoopNT-out 7.4278 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -56.89, -34.7 APE9-dihe-na -89.78, -12.26 APE8-dihe-in -151.93, 70.96 APE8-rot-out 171.34 APE67-dihe-in -55.35, -30.86 -85.9, 6.53 APE12-dist-in 9.3157 APE11-dist-in 10.4388 APE10-dist-out 14.1035 APE9-dist-out 12.3872 T165E,S171E None None XRAY 1.631 0.195 0.218 A 294.0 287.0 0 28 28 0 [[17, 274]] 1.0 9h8e STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8FA Q92918 7 293 833.0 A1ITB:301 Type1 Inactive DFGin 4.7048 13.3779 None -52.93, -40.35 -154.71, -177.86 -83.04, 10.74 51.93, 61.71 106.06, -156.77 out-out out 13.5042 Saltbr-out 12.0544 HRD-in -67.59, -55.04 63.7, 17.96 out-out-out SNCooo out-out ActLoopNT-out 7.3492 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -58.32, -34.33 APE9-dihe-na -89.38, -1.89 APE8-dihe-in -161.32, 73.17 APE8-rot-out 170.41 APE67-dihe-in -57.59, -27.85 -94.08, 8.2 APE12-dist-in 9.1755 APE11-dist-in 10.3049 APE10-dist-out 14.0403 APE9-dist-out 12.3025 T165E,S171E None None XRAY 1.393 0.203 0.246 A 294.0 287.0 0 28 28 0 [[17, 274]] 1.0 9h8f STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A Q92918 6 292 833.0 A1JAF:301 Type1 Inactive DFGin 6.4629 13.7652 None -60.93, -35.58 -154.04, -176.9 -79.86, 1.42 63.88, 19.01 105.02, -157.57 out-out out 13.2797 Saltbr-out 10.7822 HRD-in -74.09, -55.53 70.27, 5.38 out-out-out SNCooo out-out ActLoopNT-out 7.5816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -59.89, -40.77 APE9-dihe-na -92.18, -16.28 APE8-dihe-in -142.86, 74.69 APE8-rot-in 316.27 APE67-dihe-in -56.11, -27.62 -91.41, -1.8 APE12-dist-in 9.8088 APE11-dist-in 11.1344 APE10-dist-out 15.1534 APE9-dist-out 12.6983 T165E,S171E None None XRAY 1.76 0.198 0.226 A 294.0 285.0 2 28 28 0 [[17, 274]] 1.0 9qt6 STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0A Q92918 6 302 833.0 B49:9000 Type1 Inactive DFGin 5.141 15.0649 None -69.74, 172.09 -58.45, 155.47 -142.74, 154.55 54.54, 93.56 67.99, -7.56 out-out out 12.8583 Saltbr-out 10.8147 HRD-in -63.9, -48.24 77.74, -8.02 out-out-out SNCooo out-out ActLoopNT-out 10.601 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -51.88, -33.41 APE9-dihe-na -72.94, -17.4 APE8-dihe-in -134.99, 76.22 APE8-rot-in 306.88 APE67-dihe-in -54.91, -28.64 -97.55, -2.9 APE12-dist-out 23.0746 APE11-dist-out 25.0122 APE10-dist-out 24.5939 APE9-dist-out 28.7355 T165E,S171E None None XRAY 2.05 0.202 0.229 A 309.0 289.0 8 28 23 5 [[17, 274]] 1.0 6ng0 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQFA Q92918 6 293 833.0 F97:301 Type1 Inactive DFGin 4.9382 15.0175 None -68.84, 171.73 -65.96, 157.38 -148.76, 145.95 51.62, 92.75 82.89, -6.34 out-out out 12.9477 Saltbr-out 11.4708 HRD-in -70.81, -45.95 79.09, -18.39 out-out-out SNCooo out-out ActLoopNT-out 10.2868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 52.73, 67.51 APE9-dihe-na 130.19, -174.52 APE8-dihe-in -127.23, 115.01 APE8-rot-in 316.68 APE67-dihe-in -61.16, -24.43 -41.69, -51.15 APE12-dist-out 15.3177 APE11-dist-out 16.6482 APE10-dist-out 20.6876 APE9-dist-out 21.3856 None None None XRAY 2.246 0.21 0.255 A 297.0 282.0 6 28 22 6 [[17, 274]] 1.0 6cqf STE_MAP4K1_HUMAN STE 4e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9LA Q92918 7 293 833.0 2YE:60301 Type1 Inactive DFGin 5.3709 15.8708 None -79.3, 179.17 -65.19, 145.46 -137.47, 150.51 63.11, 101.31 78.13, -24.94 out-out out 13.2561 Saltbr-out 11.1556 HRD-in -72.62, -38.36 76.08, -17.52 out-out-out SNCooo out-out ActLoopNT-out 9.2967 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -49.77 APE9-dihe-na 168.11, -141.43 APE8-dihe-in -134.99, 123.61 APE8-rot-in 309.2 APE67-dihe-in -71.83, -29.15 -51.51, -37.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.9508 APE9-dist-out 20.5671 None None None XRAY 2.332 0.23 0.284 A 297.0 281.0 6 28 22 6 [[17, 274]] 1.0 7r9l STE_MAP4K1_HUMAN STE 4e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26A Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.1647 15.6986 None -90.65, 167.41 -51.45, 151.26 -138.89, 999.0 46.52, 93.57 999.0, 999.0 out-out out 13.6491 Saltbr-out 12.2657 HRD-in -70.63, -54.99 86.79, -28.34 out-out-out SNCooo out-out ActLoopNT-out 11.4078 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -80.69, -41.73 APE9-dihe-na 172.07, -144.25 APE8-dihe-in -123.38, 126.59 APE8-rot-in 309.45 APE67-dihe-in -64.56, -28.61 -52.67, -44.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.7601 S171A,G191C None None XRAY 2.3 0.263 0.298 A 287.0 280.0 7 28 25 3 [[17, 274]] 1.0 7l26 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26B Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.0526 15.9102 None -91.19, 163.6 -51.51, 146.14 -129.86, 999.0 50.48, 91.75 999.0, 999.0 out-out out 13.3954 Saltbr-out 10.5251 HRD-in -70.31, -53.37 86.88, -29.66 out-out-out SNCooo out-out ActLoopNT-out 11.6433 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, -41.02 APE9-dihe-na -160.51, -140.31 APE8-dihe-in -120.3, 127.28 APE8-rot-in 312.21 APE67-dihe-in -60.79, -31.57 -54.68, -45.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.9772 S171A,G191C None None XRAY 2.3 0.263 0.298 B 287.0 275.0 12 28 21 7 [[17, 274]] 1.0 7l26 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26C Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.2388 15.7125 None -90.03, 164.23 -51.57, 154.12 -136.67, 999.0 47.02, 92.8 999.0, 999.0 out-out out 13.5186 Saltbr-out 12.2111 HRD-in -69.66, -55.84 84.96, -26.68 out-out-out SNCooo out-out ActLoopNT-out 11.3557 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -82.36, -41.22 APE9-dihe-na 172.52, -152.31 APE8-dihe-in -119.13, 126.23 APE8-rot-in 306.88 APE67-dihe-in -64.39, -28.24 -51.56, -46.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.6383 S171A,G191C None None XRAY 2.3 0.263 0.298 C 287.0 280.0 7 28 25 3 [[17, 274]] 1.0 7l26 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26D Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.1782 15.7241 None -92.34, 166.71 -52.02, 146.05 -132.39, 999.0 51.2, 93.07 999.0, 999.0 out-out out 13.0641 Saltbr-out 11.4708 HRD-in -69.0, -53.47 85.02, -28.41 out-out-out SNCooo out-out ActLoopNT-out 10.8745 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -61.1, -36.36 APE9-dihe-na -126.65, -143.86 APE8-dihe-in -116.21, 125.85 APE8-rot-in 315.3 APE67-dihe-in -62.16, -30.12 -53.98, -45.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.6829 S171A,G191C None None XRAY 2.3 0.263 0.298 D 287.0 275.0 12 28 21 7 [[17, 274]] 1.0 7l26 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L25A Q92918 7 294 833.0 XHS:301 Type1 Inactive DFGin 4.8827 15.036 None -55.28, -37.86 -159.35, -176.67 -80.39, 10.23 63.68, 79.5 109.4, -154.39 out-out out 13.3566 Saltbr-out 10.9871 HRD-in -68.56, -54.21 74.19, 0.12 out-out-out SNCooo out-out ActLoopNT-out 6.9298 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -67.83, -24.29 APE9-dihe-na 79.98, -160.78 APE8-dihe-in -62.61, 131.99 APE8-rot-out 193.6 APE67-dihe-in -64.53, -27.32 -96.3, 1.86 APE12-dist-in 12.7847 APE11-dist-in 12.3273 APE10-dist-out 11.3185 APE9-dist-out 9.2138 S171A,G191C None None XRAY 1.85 0.187 0.227 A 289.0 288.0 0 28 28 0 [[17, 274]] 1.0 7l25 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L25B Q92918 6 293 833.0 XHS:301 Type1 Inactive DFGin 4.6918 15.1944 None -55.03, -37.48 -157.98, -176.29 -82.32, 12.4 61.67, 77.66 107.44, -152.88 out-out out 14.0546 Saltbr-out 11.4554 HRD-in -67.3, -54.15 74.75, -2.09 out-out-out SNCooo out-out ActLoopNT-out 6.9385 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -67.95, -23.75 APE9-dihe-na 79.88, -158.91 APE8-dihe-in -63.36, 133.86 APE8-rot-out 194.95 APE67-dihe-in -65.2, -27.32 -96.05, 0.4 APE12-dist-in 12.7497 APE11-dist-in 12.1983 APE10-dist-out 11.4623 APE9-dist-out 9.2011 S171A,G191C None None XRAY 1.85 0.187 0.227 B 289.0 288.0 0 28 28 0 [[17, 274]] 1.0 7l25 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7SIUA Q92918 5 294 833.0 9ID:60901 Type1.5_Back Inactive DFGin 3.8375 13.8946 None -51.62, -38.18 -156.43, -174.28 -96.36, 21.52 50.92, 94.98 81.37, -133.4 out-out out 13.4182 Saltbr-out 9.847 HRD-in -75.88, -56.67 70.34, 5.7 out-out-out SNCooo out-out ActLoopNT-out 6.9827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -60.93, -38.93 APE9-dihe-na 77.72, -173.74 APE8-dihe-in -55.84, 129.92 APE8-rot-out 190.44 APE67-dihe-in -64.04, -19.87 -98.67, -1.07 APE12-dist-out 14.7422 APE11-dist-in 11.9426 APE10-dist-out 11.923 APE9-dist-out 18.0514 None None None XRAY 1.786 0.187 0.205 A 310.0 290.0 0 28 28 0 [[17, 274]] 1.0 7siu STE_MAP4K1_HUMAN STE 4e-91 310.9 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7SIUB Q92918 16 294 833.0 9ID:60301 Type1.5_Back Inactive DFGin 5.0764 13.4832 None -53.44, -36.92 -155.11, -179.05 -87.99, 18.37 47.54, 74.7 106.16, -161.65 out-out out 12.3832 Saltbr-out 8.7904 HRD-in -71.24, -52.8 63.02, 13.42 out-out-out SNCooo out-out ActLoopNT-out 7.1653 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -100.2, -45.71 APE9-dihe-na 128.51, -162.4 APE8-dihe-in -63.73, 151.22 APE8-rot-out 52.58 APE67-dihe-in -59.58, -25.5 -100.41, 4.16 APE12-dist-out 16.9549 APE11-dist-out 16.6118 APE10-dist-out 17.1001 APE9-dist-out 21.748 None None None XRAY 1.786 0.187 0.205 B 310.0 279.0 0 28 28 0 [[17, 274]] 1.0 7siu STE_MAP4K1_HUMAN STE 4e-91 310.9 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE OXSR1 OXSR1_HUMAN 2VWIA O95747 13 292 527.0 ANP:1294 ATPlike Inactive DFGin 8.898 15.6012 None -61.18, 158.62 -55.34, 143.64 -131.37, -0.25 74.39, 103.15 -56.05, -46.66 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.19, -49.86 82.28, -11.12 none-out-out SNCnoo out-out ActLoopNT-out 5.9984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.6 APE8-dihe-in -114.29, 105.56 APE8-rot-out 57.55 APE67-dihe-in -58.83, -26.11 -92.35, 9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.1357 None None None XRAY 2.15 0.253 0.287 A 303.0 237.0 43 33 18 15 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 4O0TB Q13153 255 542 545.0 No_ligand No_ligand Inactive DFGin 8.1487 13.6047 None -152.82, 167.65 64.98, 77.89 -160.54, 999.0 57.61, 97.43 999.0, 999.0 out-out out 11.064 Saltbr-out 8.0427 HRD-in -68.58, -49.06 70.12, -10.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -113.09, 110.46 APE9-dihe-na 88.48, 133.73 APE8-dihe-in -75.78, 128.16 APE8-rot-in 298.99 APE67-dihe-out -65.51, -17.68 -81.05, 73.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.689 None None None XRAY 2.6 0.217 0.265 B 300.0 280.0 8 28 20 8 [[270, 521]] 1.0 4o0t STE_PAK1_HUMAN STE 3.4e-94 320.9 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3Q4ZB Q13153 250 541 545.0 No_ligand No_ligand Inactive DFGin 8.0015 14.8016 None -130.95, 172.79 58.85, 58.79 -133.76, 999.0 55.71, 98.96 999.0, 999.0 out-none out 11.7739 Saltbr-none 999.0 HRD-in -65.63, -50.79 80.23, -14.67 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -106.94, -63.76 APE9-dihe-na -80.08, 161.6 APE8-dihe-in -94.98, 117.43 APE8-rot-in 294.62 APE67-dihe-out -66.0, -21.92 -79.94, 65.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0344 S259I,K299R,D389N,L516I None None XRAY 1.887 0.186 0.231 B 306.0 279.0 13 28 19 9 [[270, 521]] 1.0 3q4z STE_PAK1_HUMAN STE 2e-93 318.4 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 7VTOB Q13153 255 542 545.0 107:601 Type1 Inactive DFGin 7.5191 14.7279 None -159.98, 174.54 62.98, 54.4 -135.2, 999.0 55.36, 102.9 999.0, 999.0 out-out out 11.3279 Saltbr-out 10.0201 HRD-in -69.73, -51.99 75.23, -8.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -62.21, -39.34 APE9-dihe-na 160.98, -155.85 APE8-dihe-out 82.87, 12.18 APE8-rot-out 62.27 APE67-dihe-in -60.81, -30.13 -80.78, 2.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6877 None TPO423 TPO423 XRAY 2.59 0.236 0.252 B 301.0 278.0 10 28 18 10 [[270, 521]] 1.0 7vto STE_PAK1_HUMAN STE 1.7e-94 321.9 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5DEYB Q13153 255 542 545.0 59T:601 Type1 Inactive DFGin 7.3498 15.4583 None -123.29, 170.33 -82.44, 174.75 -121.32, 55.91 7.6, 122.84 -96.3, -43.82 out-out out 11.7695 Saltbr-out 9.8581 HRD-in -72.29, -49.87 79.14, -22.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -79.22, -70.08 APE9-dihe-na -89.37, 158.31 APE8-dihe-in -85.28, 117.06 APE8-rot-in 296.79 APE67-dihe-out -66.47, -20.46 -79.34, 69.72 APE12-dist-out 19.4815 APE11-dist-out 16.9726 APE10-dist-out 15.3171 APE9-dist-out 12.9671 D389N,T423E None None XRAY 2.1 0.186 0.228 B 297.0 281.0 7 28 21 7 [[270, 521]] 1.0 5dey STE_PAK1_HUMAN STE 3.3e-94 321.0 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5IMEB Q13153 250 541 545.0 6BZ:60601 Type1 Inactive DFGin 6.7938 15.4227 None -141.05, 172.61 52.99, 75.91 -151.54, 999.0 56.92, 93.17 999.0, 999.0 out-out out 12.9033 Saltbr-out 9.9854 HRD-in -70.09, -49.96 77.67, -19.32 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -67.92, -63.94 APE9-dihe-na -112.92, 178.31 APE8-dihe-in -97.52, 114.89 APE8-rot-in 302.24 APE67-dihe-out -63.71, -21.19 -77.9, 63.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7136 None None None XRAY 2.217 0.226 0.263 B 300.0 280.0 12 28 20 8 [[270, 521]] 1.0 5ime STE_PAK1_HUMAN STE 3.4e-94 320.9 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4FIGB O96013 298 590 591.0 ANP:602 ATPlike Inactive DFGin 5.9786 13.8453 None -136.1, -40.27 -82.41, 70.29 -85.54, 12.48 305.29, 106.7 -66.77, -24.27 in-in in 7.0074 Saltbr-in 3.0472 HRD-in -63.37, -48.9 73.21, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.9294 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.8, 141.64 APE9-dihe-na 130.69, -165.45 APE8-dihe-in -110.43, 122.9 APE8-rot-in 324.7 APE67-dihe-in -77.33, -31.89 -29.23, -51.11 APE12-dist-in 9.7059 APE11-dist-in 11.7431 APE10-dist-in 5.9203 APE9-dist-in 3.3864 None SEP474 SEP474 XRAY 3.01 0.197 0.221 B 346.0 293.0 0 28 28 0 [[321, 572]] 1.0 4fig STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK10 STK10_HUMAN 5AJQA O94804 24 312 968.0 DB8:800 Type1 Inactive DFGin 6.2593 15.7439 None -120.59, 174.2 81.32, -56.36 57.24, 29.42 287.8, 79.18 102.53, -17.28 out-out out 10.7485 Saltbr-out 10.9466 HRD-in -68.33, -48.71 84.04, -21.17 out-out-out SNCooo out-out ActLoopNT-out 12.5732 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -85.91, 130.23 APE9-dihe-na 91.1, 7.46 APE8-dihe-in -59.1, 130.74 APE8-rot-in 288.9 APE67-dihe-out -66.14, -20.66 -86.49, 69.24 APE12-dist-none 999.0 APE11-dist-out 18.6923 APE10-dist-out 14.1461 APE9-dist-out 10.6821 None None None XRAY 2.2 0.219 0.257 A 295.0 280.0 9 28 22 6 [[36, 294]] 1.0 5ajq STE_STK10_HUMAN STE 1.9e-94 321.7 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5AJQB O94804 25 312 968.0 DB8:800 Type1 Inactive DFGin 6.2863 15.9394 None -120.49, 173.38 83.25, -57.95 53.22, 23.51 288.78, 77.4 -62.81, -49.77 out-none out 10.8902 Saltbr-none 999.0 HRD-in -69.73, -48.6 82.63, -20.29 none-out-none SNCnon out-none ActLoopNT-out 6.6725 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 83.37 APE8-rot-in 290.95 APE67-dihe-in -67.97, -24.14 -101.21, 28.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.219 0.257 B 295.0 267.0 21 28 15 13 [[36, 294]] 1.0 5ajq STE_STK10_HUMAN STE 1.9e-94 321.7 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 4O27B Q9Y6E0 30 309 443.0 ADP:60500 ATPlike Inactive DFGin 4.8671 13.8197 None -148.38, -173.28 56.25, -124.14 31.74, 82.19 64.76, 101.5 98.89, -78.6 in-in in 8.9372 Saltbr-in 2.9006 HRD-in -80.55, -48.63 69.48, -10.03 in-in-out SNCiio in-out ActLoopNT-in 3.0174 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.0, 177.15 APE9-dihe-na 103.58, 170.34 APE8-dihe-in -99.19, 143.02 APE8-rot-out 34.53 APE67-dihe-in -72.39, -25.42 -54.44, -42.62 APE12-dist-in 9.0284 APE11-dist-in 10.879 APE10-dist-in 5.5618 APE9-dist-in 3.6436 T190E None None XRAY 3.185 0.203 0.26 B 281.0 280.0 0 28 28 0 [[36, 286]] 1.0 4o27 STE_STK24_HUMAN STE 5.5e-100 339.9 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK26 STK26_HUMAN 3GGFA Q9P289 17 300 416.0 GVD:305 Type1 Inactive DFGin 6.5129 17.533 None -107.18, 8.32 -96.74, 1.83 -77.63, 129.12 182.23, 74.2 -169.36, -175.42 out-out out 13.2679 Saltbr-out 11.9131 HRD-out -112.33, 146.97 -132.0, 153.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.52, -49.61 APE9-dihe-na 109.3, -174.5 APE8-dihe-in -89.03, 130.3 APE8-rot-out 188.7 APE67-dihe-in -59.01, -28.43 -93.03, -11.97 APE12-dist-out 20.7255 APE11-dist-out 20.0751 APE10-dist-out 20.4716 APE9-dist-out 12.3677 None None None XRAY 2.35 0.222 0.277 A 301.0 275.0 9 28 19 9 [[24, 274]] 1.0 3ggf STE_STK26_HUMAN STE 3.5e-100 340.6 1.0 257.0 257.0 161 162 163 165 167 53 70 74 141 143 142 144.0 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 3GGFB Q9P289 18 297 416.0 GVD:304 Type1 Inactive DFGin 6.381 17.7152 None -107.34, 9.0 -94.45, -5.79 -73.15, 129.62 180.07, 74.63 -158.4, -173.99 out-out out 13.2479 Saltbr-out 12.1703 HRD-out -111.96, 147.3 -128.45, 152.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.97, -49.3 APE9-dihe-na 108.76, -176.86 APE8-dihe-in -86.01, 129.64 APE8-rot-out 192.14 APE67-dihe-in -66.2, -27.4 -96.0, -3.24 APE12-dist-out 20.1506 APE11-dist-out 19.5281 APE10-dist-out 20.0681 APE9-dist-out 11.8722 None None None XRAY 2.35 0.222 0.277 B 301.0 270.0 10 28 18 10 [[24, 274]] 1.0 3ggf STE_STK26_HUMAN STE 3.5e-100 340.6 1.0 257.0 257.0 161 162 163 165 167 53 70 74 141 143 142 144.0 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE STK3 STK3_HUMAN 4LG4F Q13188 18 310 491.0 No_ligand No_ligand Inactive DFGin 4.7998 15.1909 None -138.38, 162.54 47.11, 83.6 -66.57, 999.0 302.94, 84.23 999.0, 999.0 out-out out 10.7899 Saltbr-out 6.4196 HRD-in -72.45, -47.39 76.74, -5.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -102.3 APE8-dihe-in -134.65, 156.4 APE8-rot-out 45.22 APE67-dihe-in -63.77, -27.55 -98.01, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1214 D146N None None XRAY 2.42 0.194 0.231 F 299.0 276.0 17 28 11 17 [[27, 278]] 1.0 4lg4 STE_STK3_HUMAN STE 1.9e-100 341.5 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STRADA STRAA_HUMAN 8VSUB Q7RTN6 60 401 431.0 ADP:2001 ATPlike Pseudo DFGin 5.3284 13.7435 None -141.72, 9.36 -84.56, 30.72 -65.1, -14.12 305.81, 3.72 -62.58, -31.2 out-none out 10.2295 Saltbr-none 999.0 HRD-out -66.66, 151.23 -136.62, 153.73 none-in-out SNCnio in-out ActLoopNT-in 2.8656 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -55.51, -37.77 APE9-dihe-na -75.16, -6.37 APE8-dihe-out -108.58, -14.7 APE8-rot-na 180.94 APE67-dihe-in -58.61, -34.89 -50.23, -38.37 APE12-dist-in 8.3418 APE11-dist-out 7.821 APE10-dist-out 13.0573 APE9-dist-out 11.0521 None None None EM 2.86 999.0 999.0 B 429.0 306.0 36 35 35 0 [[69, 379]] 1.0 8vsu STE_STRADA_HUMAN STE 6.5e-87 297.3 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TNIK TNIK_HUMAN 2X7FE Q9UKE5 14 309 1360.0 824:500 Type1 Inactive DFGin 6.6596 14.7942 None -124.38, 176.52 58.71, 103.53 -115.64, 999.0 286.98, 84.26 999.0, 999.0 in-none in 9.525 Saltbr-none 999.0 HRD-in -65.29, -41.79 67.65, -3.62 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.45 APE8-rot-none 999.0 APE67-dihe-in -51.92, -33.29 -95.18, 3.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 E 326.0 251.0 45 28 10 18 [[25, 289]] 1.0 2x7f STE_TNIK_HUMAN STE 3.7e-105 356.8 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 6T6DA Q04771 204 499 509.0 MM8:501 Type1 Inactive DFGin 8.3091 13.2837 None -109.51, -81.12 -73.5, 111.71 -110.98, 17.65 271.3, 88.6 -66.37, -17.62 in-in in 8.1368 Saltbr-in 3.4958 HRD-in -71.72, -59.58 84.73, 1.24 in-in-in SNCiii in-in ActLoopNT-in 2.8829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.15, 12.06 APE9-dihe-na -92.9, 178.87 APE8-dihe-in -69.31, 121.79 APE8-rot-in 306.54 APE67-dihe-in -58.18, -27.15 -60.78, -34.02 APE12-dist-in 12.1633 APE11-dist-in 11.7611 APE10-dist-in 6.6141 APE9-dist-in 3.7745 Q207D None None XRAY 2.56 0.224 0.272 A 301.0 292.0 4 32 28 4 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL BRAF BRAF_HUMAN 4XV3B P15056 448 705 766.0 No_ligand No_ligand Inactive DFGin 6.2845 15.0635 None -134.59, -161.64 56.33, 52.08 -63.4, 999.0 279.75, 63.83 999.0, 999.0 in-in in 8.9281 Saltbr-in 3.3244 HRD-in -65.71, -41.29 62.65, 10.76 in-in-out SNCiio in-out ActLoopNT-in 2.9826 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -32.28 APE8-dihe-out -76.54, 7.27 APE8-rot-in 304.4 APE67-dihe-in -61.73, -25.86 -63.95, -33.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7011 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.8 0.26 0.296 B 292.0 225.0 33 30 14 16 [[457, 716]] 1.0 4xv3 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4FK3B P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 5.7722 14.711 None -140.8, -152.47 49.25, 52.94 -56.33, -72.64 272.7, 56.86 47.33, -79.68 in-out in 9.0449 Saltbr-out 5.3726 HRD-in -75.07, -44.36 65.22, -1.5 out-in-out SNCoio in-out ActLoopNT-in 3.1937 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 141.11 APE9-dihe-na 86.3, -24.42 APE8-dihe-out -101.18, 22.22 APE8-rot-out 89.79 APE67-dihe-in -68.94, -26.21 -73.51, -33.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1316 APE9-dist-out 11.411 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.262 0.315 B 292.0 257.0 17 30 17 13 [[457, 716]] 1.0 4fk3 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3OG7B P15056 449 720 766.0 No_ligand No_ligand Inactive DFGin 5.9606 14.3845 None -166.94, -137.57 40.92, 51.52 -52.94, -84.66 283.54, 98.08 68.73, -46.65 in-in in 8.951 Saltbr-in 2.5878 HRD-in -73.27, -47.93 73.19, 0.79 in-in-out SNCiio in-out ActLoopNT-in 2.9692 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.76 APE8-dihe-out -68.94, -9.04 APE8-rot-in 313.5 APE67-dihe-in -62.19, -30.71 -52.08, -39.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0366 K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.45 0.214 0.258 B 289.0 254.0 18 30 16 14 [[457, 716]] 1.0 3og7 TKL_BRAF_HUMAN TKL 1.2e-83 286.6 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6UUOA P15056 450 722 766.0 QH1:801 Type1 Inactive DFGin 5.4833 13.5755 None -154.98, -157.82 59.8, 46.61 -126.81, 999.0 56.6, 86.97 999.0, 999.0 out-none out 10.4408 Saltbr-none 999.0 HRD-out -76.54, 102.1 -78.95, -33.04 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -71.64, -31.02 APE9-dihe-na -70.11, -42.33 APE8-dihe-out -89.38, 32.83 APE8-rot-in 313.94 APE67-dihe-in -71.42, -39.61 -73.97, -40.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.3262 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.288 0.265 0.288 A 284.0 254.0 19 30 16 14 [[457, 716]] 1.0 6uuo TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4H58A P15056 448 722 766.0 10Z:60801 Type1 Inactive DFGin 5.9602 13.7224 None -110.59, -118.32 -39.31, 108.26 -95.89, 11.56 277.46, 88.25 -35.77, -74.73 in-in in 8.3024 Saltbr-in 2.7643 HRD-in -69.13, -43.65 65.49, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.8347 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, 79.67 APE9-dihe-na -70.74, 22.44 APE8-dihe-in -101.01, 94.21 APE8-rot-in 260.42 APE67-dihe-in -50.49, -22.55 -89.83, -41.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.5653 APE9-dist-out 10.3075 None None None XRAY 3.1 0.224 0.272 A 275.0 263.0 12 30 18 12 [[457, 716]] 1.0 4h58 TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3PRFB P15056 448 723 766.0 FP3:727 Type1 Inactive DFGin 6.4282 13.6432 None -169.57, 116.91 168.47, 123.69 -125.85, 47.13 283.69, 79.02 -70.43, 82.93 in-in in 8.1536 Saltbr-in 2.9967 HRD-in -67.72, -35.03 62.32, -6.1 in-out-out SNCioo out-out ActLoopNT-out 5.6019 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -169.48 APE8-dihe-in -103.48, 122.52 APE8-rot-in 275.2 APE67-dihe-in -59.13, -20.14 -98.86, -20.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.5263 None None None XRAY 2.9 0.271 0.31 B 307.0 262.0 14 30 16 14 [[457, 716]] 1.0 3prf TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5CSWA P15056 449 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.5631 13.7249 None -154.89, -152.27 52.45, 58.54 -68.5, 999.0 303.98, 168.7 999.0, 999.0 out-out out 10.269 Saltbr-out 7.4286 HRD-in -64.98, -59.02 86.25, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 30.46 APE8-dihe-out -158.22, 46.88 APE8-rot-in 285.64 APE67-dihe-in -66.32, -23.33 -79.02, -14.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3642 R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.66 0.22 0.282 A 282.0 254.0 19 30 11 19 [[457, 716]] 1.0 5csw TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5ITAB P15056 448 721 766.0 6DC:801 Type1.5_Back Inactive DFGin 5.3633 13.8031 None -122.71, -173.14 61.94, 63.43 -148.55, 999.0 64.56, 89.23 999.0, 999.0 out-in out 10.3514 Saltbr-in 3.533 HRD-in -69.84, -55.2 76.82, -4.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -11.31 APE9-dihe-na -82.19, 19.66 APE8-dihe-out -126.85, 23.68 APE8-rot-in 305.8 APE67-dihe-in -61.03, -25.66 -65.06, -28.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3333 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 1.95 0.197 0.244 B 297.0 252.0 22 30 12 18 [[457, 716]] 1.0 5ita TKL_BRAF_HUMAN TKL 5.7e-84 287.8 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2UA P15056 449 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.7852 13.8715 None -154.67, -156.07 52.1, 63.13 -70.26, 999.0 290.51, 178.01 999.0, 999.0 out-none out 10.2704 Saltbr-none 999.0 HRD-in -70.43, -53.73 79.13, -11.56 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, -132.33 APE9-dihe-na -124.36, 116.11 APE8-dihe-in -169.83, 67.75 APE8-rot-in 288.88 APE67-dihe-in -62.03, -24.27 -79.94, -15.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4864 None None None XRAY 3.78 0.282 0.309 A 283.0 255.0 18 30 12 18 [[457, 716]] 1.0 6v2u TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MBJA P15056 448 723 766.0 DFS:801 Type1.5_Back Inactive DFGin 5.0397 14.1722 None -105.17, -97.55 -92.89, 45.25 -92.17, -5.13 71.79, 75.67 -66.15, 168.52 out-out out 11.9053 Saltbr-out 10.1254 HRD-in -75.95, -40.1 71.4, -7.47 out-out-out SNCooo out-out ActLoopNT-out 8.6902 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na 173.82, -65.98 APE9-dihe-na -61.43, -19.22 APE8-dihe-in -120.24, 91.44 APE8-rot-out 31.9 APE67-dihe-in -51.31, -26.45 -118.43, -32.49 APE12-dist-none 999.0 APE11-dist-out 14.5191 APE10-dist-out 17.7046 APE9-dist-out 11.0704 None None None XRAY 3.6 0.276 0.328 A 304.0 269.0 7 30 23 7 [[457, 716]] 1.0 4mbj TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MBJB P15056 448 723 766.0 DFS:801 Type1.5_Back Inactive DFGin 5.0227 14.1491 None -106.4, -95.1 -95.18, 47.42 -92.84, -5.68 72.56, 75.57 -66.19, 170.04 out-out out 11.925 Saltbr-out 10.2011 HRD-in -72.66, -45.72 76.66, -7.37 out-out-out SNCooo out-out ActLoopNT-out 8.7036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na 171.46, -66.25 APE9-dihe-na -61.77, -19.59 APE8-dihe-in -119.83, 90.82 APE8-rot-out 33.61 APE67-dihe-in -51.95, -27.84 -118.81, -32.64 APE12-dist-in 11.2516 APE11-dist-out 14.4922 APE10-dist-out 17.6929 APE9-dist-out 11.058 None None None XRAY 3.6 0.276 0.328 B 304.0 276.0 0 30 30 0 [[457, 716]] 1.0 4mbj TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 8TVMD Q9NWZ3 164 459 460.0 VDC:501 Type1 Inactive DFGin 7.8031 14.7146 None -126.76, 170.55 55.84, 64.27 -89.21, 999.0 333.58, 116.07 999.0, 999.0 in-out in 9.0975 Saltbr-out 4.7491 HRD-in -67.23, -50.36 76.24, -8.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -109.51, 116.74 APE9-dihe-na 179.74, -172.21 APE8-dihe-in -111.79, 118.52 APE8-rot-out 41.22 APE67-dihe-in -67.21, -19.62 -56.37, -42.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.276 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 D 307.0 277.0 19 30 19 11 [[183, 456]] 1.0 8tvm TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97B Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.2944 14.2173 None -136.34, -175.59 46.99, 62.58 -120.73, 999.0 61.34, 86.78 999.0, 999.0 in-in in 9.393 Saltbr-in 2.9962 HRD-in -71.9, -50.3 83.45, -13.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -128.91, -19.36 APE9-dihe-na -55.91, 145.79 APE8-dihe-in -64.15, 91.3 APE8-rot-in 291.9 APE67-dihe-in -57.49, -34.64 -51.29, -30.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1454 D311N None None XRAY 2.65 0.206 0.251 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u97 TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AB Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.6327 14.406 None -136.0, 173.79 77.97, 80.6 -165.88, 999.0 67.94, 103.04 999.0, 999.0 in-in in 9.4018 Saltbr-in 2.9242 HRD-in -69.54, -47.75 75.57, 5.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -138.84, -18.64 APE9-dihe-na -63.49, 153.65 APE8-dihe-in -64.27, 92.38 APE8-rot-in 304.32 APE67-dihe-in -63.41, -26.11 -54.68, -17.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3588 D311N None None XRAY 2.8 0.185 0.24 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u9a TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LIMK1 LIMK1_HUMAN 5HVKC P53667 329 633 647.0 ANP:60701 ATPlike Inactive DFGin 6.0783 13.9339 None -149.69, 172.69 -101.87, 169.41 -110.21, 23.25 306.34, 92.8 -73.91, -25.16 in-out in 7.8911 Saltbr-out 3.6442 HRD-in -72.39, -44.63 59.79, 17.6 out-in-in SNCoii in-in ActLoopNT-in 3.0698 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.53, 148.22 APE9-dihe-na 140.89, 172.08 APE8-dihe-in -72.12, 119.75 APE8-rot-na 199.66 APE67-dihe-in -64.48, -35.33 -54.5, -33.22 APE12-dist-in 8.6689 APE11-dist-in 11.1988 APE10-dist-in 5.8992 APE9-dist-in 3.5423 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 C 315.0 291.0 14 42 28 14 [[339, 606]] 1.0 5hvk TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5NXCL P53667 330 632 647.0 9DB:60701 Type1 Inactive DFGin 6.1921 12.9336 None -122.26, 162.54 70.04, 26.42 -74.72, 999.0 43.09, 84.18 999.0, 999.0 out-out out 14.186 Saltbr-out 16.3784 HRD-in -67.42, -56.12 78.54, -18.62 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -87.18 APE8-dihe-in -64.64, 140.22 APE8-rot-na 296.78 APE67-dihe-in -58.15, -27.29 -88.8, 19.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.065 None None None XRAY 2.25 0.242 0.298 L 310.0 272.0 31 42 11 31 [[339, 606]] 1.0 5nxc TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LRRK2 LRRK2_HUMAN 8TZHA Q5S007 627 2522 2527.0 A1N:2601 Type1 Inactive DFGin 5.1887 13.0236 None -82.7, -162.66 -41.82, 136.94 -146.23, 112.92 28.36, 40.7 -50.64, 999.0 in-out in 9.2107 Saltbr-out 4.5645 HRD-in -114.23, -59.07 54.02, 31.73 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.84 APE8-dihe-in -145.38, 140.36 APE8-rot-in 326.06 APE67-dihe-in -90.26, -10.83 -64.13, -43.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.2169 None None None EM 3.9 999.0 999.0 A 2527.0 1485.0 21 26 12 14 [[1875, 2134]] 1.0 8tzh TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 9CHOA Q5S007 543 2527 2527.0 A1N:2701 Type1 Inactive DFGin 6.0139 12.2545 None -87.37, -156.77 -42.12, 141.81 -109.94, -179.33 314.03, 99.42 -59.72, 999.0 in-out in 9.1584 Saltbr-out 5.5545 HRD-in -73.99, -50.39 47.44, 27.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.86 APE8-dihe-in -153.53, 148.49 APE8-rot-in 317.08 APE67-dihe-in -67.05, -9.98 -58.64, -41.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7475 I2020T None None EM 7.8 999.0 999.0 A 1985.0 1792.0 21 26 12 14 [[1875, 2134]] 1.0 9cho TKL_LRRK2_HUMAN TKL 4.9e-57 199.8 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL MAP3K12 M3K12_HUMAN 9CDXA Q12852 117 397 859.0 A1AZP:501 Type1 Inactive DFGin 6.5428 13.646 None -140.44, 159.48 81.4, 17.88 -85.98, 999.0 46.51, 94.56 999.0, 999.0 out-na out 13.7947 Saltbr-na 13.5441 HRD-in -72.41, -54.6 86.63, -24.49 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -169.44 APE8-dihe-out -120.92, 37.67 APE8-rot-out 62.69 APE67-dihe-in -60.76, -27.81 -70.5, -18.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6787 None None None XRAY 2.38 0.234 0.284 A 300.0 265.0 16 27 11 16 [[118, 372]] 1.0 9cdx TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
TKL MAP3K7 M3K7_HUMAN 8GW3A O43318 27 497 606.0 No_ligand No_ligand Inactive DFGin 6.6472 11.7225 None -119.33, 8.38 -158.05, 154.61 -116.24, 147.16 288.24, 68.47 -75.8, 166.21 out-out out 13.9572 Saltbr-out 9.2042 HRD-in -71.65, -49.3 87.44, -14.15 out-out-out SNCooo out-out ActLoopNT-out 10.0952 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -82.82, -0.21 APE9-dihe-na 77.02, 24.75 APE8-dihe-out -104.16, 8.77 APE8-rot-in 301.46 APE67-dihe-in -66.78, -13.89 -61.71, -40.48 APE12-dist-in 12.1847 APE11-dist-out 14.8778 APE10-dist-out 9.0724 APE9-dist-out 10.7885 None None None XRAY 2.05 0.223 0.258 A 326.0 277.0 0 25 25 0 [[36, 286]] 1.0 8gw3 TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 5JH6A O43318 31 496 606.0 T92:60601 Type1 Inactive DFGin 10.5293 14.5522 None -137.04, 121.24 -83.75, 119.82 52.98, 999.0 303.28, 108.15 999.0, 999.0 out-out out 10.4819 Saltbr-out 6.598 HRD-in -75.23, -38.87 70.62, -74.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 61.21 APE8-dihe-out -98.25, 8.68 APE8-rot-in 298.96 APE67-dihe-in -65.25, -26.33 -63.14, -30.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8877 None None None XRAY 2.365 0.227 0.253 A 314.0 255.0 18 25 11 14 [[36, 286]] 1.0 5jh6 TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 5GJGA O43318 31 496 606.0 6V5:60601 Type1 Inactive DFGin 5.2837 13.1578 None -118.05, 171.86 68.2, 36.7 -74.01, 999.0 61.15, 90.63 999.0, 999.0 out-out out 15.749 Saltbr-out 14.4672 HRD-in -70.48, -40.96 66.77, -23.12 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 72.06 APE8-dihe-out -80.43, -1.77 APE8-rot-in 291.81 APE67-dihe-in -68.91, -20.48 -57.04, -35.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7194 None None None XRAY 2.61 0.183 0.221 A 315.0 259.0 14 25 11 14 [[36, 286]] 1.0 5gjg TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL RAF1 RAF1_HUMAN 8CPDA P04049 341 626 648.0 No_ligand No_ligand Inactive DFGin 6.2527 14.8427 None -88.44, -129.65 -68.47, 153.64 -115.46, 32.54 280.62, 22.29 -59.2, -38.85 in-in in 8.9962 Saltbr-in 3.2393 HRD-out -71.21, -9.87 61.06, -133.06 in-in-out SNCiio in-out ActLoopNT-in 3.3344 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -31.3 APE9-dihe-na -64.2, -40.67 APE8-dihe-in -125.25, 125.51 APE8-rot-in 293.24 APE67-dihe-in -70.13, -31.13 -109.07, 11.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.0605 APE9-dist-out 15.3926 Y341D SEP621 SEP621 EM 3.46 999.0 999.0 A 648.0 269.0 17 30 18 12 [[349, 608]] 1.0 8cpd TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CPDB P04049 341 626 648.0 No_ligand No_ligand Inactive DFGin 6.3243 14.7834 None -88.37, -130.06 -68.25, 153.07 -115.22, 33.93 283.48, 10.19 -59.44, -38.94 in-in in 8.9968 Saltbr-in 3.2413 HRD-out -70.18, -11.24 60.41, -132.52 in-in-out SNCiio in-out ActLoopNT-in 3.2815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -32.01 APE9-dihe-na -64.34, -40.91 APE8-dihe-in -123.99, 124.82 APE8-rot-in 292.66 APE67-dihe-in -70.59, -30.16 -110.37, 10.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.0602 APE9-dist-out 15.4329 Y341D SEP621 SEP621 EM 3.46 999.0 999.0 B 648.0 269.0 17 30 18 12 [[349, 608]] 1.0 8cpd TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 3OMVA P04049 340 615 648.0 SM5:1 Type1 Inactive DFGin 6.0105 14.0395 None -72.19, -157.95 -69.65, 158.45 -112.95, 18.14 298.92, 73.64 -38.54, -34.68 in-in in 8.8405 Saltbr-in 2.8181 HRD-in -81.59, -27.52 64.4, -79.14 in-in-out SNCiio in-out ActLoopNT-in 3.128 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -67.59, 120.25 APE9-dihe-na -106.5, 137.12 APE8-dihe-in -106.61, 64.59 APE8-rot-out 44.73 APE67-dihe-inflip 112.91, -48.44 -57.65, 161.85 APE12-dist-none 999.0 APE11-dist-in 13.3289 APE10-dist-out 12.1479 APE9-dist-out 10.4545 None None None XRAY 4.0 0.283 0.364 A 307.0 264.0 12 30 18 12 [[349, 608]] 1.0 3omv TKL_RAF1_HUMAN TKL 3.7e-81 278.6 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFA P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9193 13.7979 None -77.69, -137.87 -62.1, 150.83 -123.34, 43.11 304.09, 90.48 -53.76, -47.63 in-out in 8.5922 Saltbr-out 6.6899 HRD-in -62.51, -43.32 69.96, -9.45 out-in-out SNCoio in-out ActLoopNT-in 2.8262 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.92, 40.68 APE8-dihe-in -131.33, 94.1 APE8-rot-out 59.25 APE67-dihe-inflip 81.42, -0.92 -97.97, 165.62 APE12-dist-in 7.3494 APE11-dist-in 11.6311 APE10-dist-in 6.9434 APE9-dist-out 10.1571 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 A 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFB P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9191 13.7979 None -77.67, -137.85 -62.16, 150.83 -123.29, 43.03 304.08, 90.5 -53.73, -47.64 in-out in 8.5922 Saltbr-out 6.6905 HRD-in -62.53, -43.31 69.92, -9.4 out-in-out SNCoio in-out ActLoopNT-in 2.8268 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.89, 40.65 APE8-dihe-in -131.28, 94.15 APE8-rot-out 59.25 APE67-dihe-inflip 81.39, -0.89 -98.01, 165.61 APE12-dist-in 7.3494 APE11-dist-in 11.631 APE10-dist-in 6.9423 APE9-dist-out 10.1569 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 B 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RIPK2 RIPK2_HUMAN 5W5JA O43353 9 310 540.0 9WS:401 Type1 Inactive DFGin 6.0636 11.774 None -119.1, 58.24 -81.72, 48.17 -169.21, 999.0 29.16, 78.79 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-out -76.29, 33.51 -93.6, 157.22 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.86 APE8-rot-out 51.78 APE67-dihe-in -59.34, -25.23 -55.53, -13.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 A 310.0 251.0 51 33 10 23 [[18, 292]] 1.0 5w5j TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5W5JB O43353 10 311 540.0 9WS:401 Type1 Inactive DFGin 10.6638 12.427 None -117.65, 82.68 -113.99, 168.64 -106.24, 999.0 178.58, 75.53 999.0, 999.0 out-none out 12.7338 Saltbr-none 999.0 HRD-none 999.0, -168.86 -106.07, -61.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.02 APE8-rot-out 182.83 APE67-dihe-in -59.02, -25.25 -78.75, -12.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 B 310.0 257.0 45 33 10 23 [[18, 292]] 1.0 5w5j TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 6FU5B O43353 5 316 540.0 E7N:400 Type1 Inactive DFGin 5.9966 14.4823 None -152.27, 168.89 72.98, 59.18 -85.18, 999.0 313.99, 145.21 999.0, 999.0 in-in in 8.2541 Saltbr-in 3.2918 HRD-in -67.82, -57.29 58.73, 20.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 33.08 APE8-dihe-out -121.2, 5.37 APE8-rot-out 45.9 APE67-dihe-in -54.25, -32.94 -85.9, -14.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.8037 None None None XRAY 3.26 0.231 0.271 B 317.0 286.0 26 33 11 22 [[18, 292]] 1.0 6fu5 TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 9F3VA O43353 9 314 540.0 A1H90:401 Type1 Inactive DFGin 6.1196 11.6318 None -123.15, 40.28 -90.71, 70.0 -87.39, 999.0 300.2, 126.34 999.0, 999.0 out-out out 12.4585 Saltbr-out 11.3915 HRD-out -117.23, 144.8 -142.51, 123.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.92 APE8-rot-out 194.2 APE67-dihe-in -71.3, -18.73 -128.19, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 A 320.0 271.0 35 33 10 23 [[18, 292]] 1.0 9f3v TKL_RIPK2_HUMAN TKL 5e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 9F3VB O43353 9 315 540.0 A1H90:401 Type1 Inactive DFGin 6.1588 11.1837 None -124.64, 37.34 -86.49, 73.07 -88.12, -171.81 302.83, 123.42 -66.33, -25.78 out-out out 11.9434 Saltbr-out 13.034 HRD-out -117.06, 146.57 -143.26, 122.43 out-out-out SNCooo out-out ActLoopNT-out 9.0527 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.32 APE8-rot-out 190.74 APE67-dihe-in -70.4, -21.68 -126.9, 0.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 B 320.0 278.0 29 33 15 18 [[18, 292]] 1.0 9f3v TKL_RIPK2_HUMAN TKL 5e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR8A O43353 9 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.4925 13.7371 None -145.13, 172.75 65.95, 57.21 -55.82, 999.0 299.0, 99.97 999.0, 999.0 out-out out 11.8351 Saltbr-out 10.7188 HRD-in -72.15, -51.23 60.29, 11.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.34 APE8-dihe-in -100.17, 152.95 APE8-rot-out 191.99 APE67-dihe-in -63.35, -16.88 -126.62, -2.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0407 None None None XRAY 2.79 0.204 0.233 A 326.0 255.0 47 33 11 22 [[18, 292]] 1.0 5ar8 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR ALK ALK_HUMAN 2YJRA Q9UM73 1101 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.3091 14.7033 None -109.22, -156.6 -24.57, 131.48 -106.45, 12.37 294.91, 66.22 -54.96, -56.35 in-in in 7.9428 Saltbr-in 3.1237 HRD-in -78.17, -44.51 78.03, -12.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.23, -22.26 APE9-dihe-in -61.19, 130.79 APE8-dihe-in -74.37, 65.56 APE8-rot-na 28.22 APE67-dihe-in -67.2, -14.23 -60.39, -32.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8552 F1174L None None XRAY 1.9 0.221 0.281 A 342.0 281.0 21 30 16 14 [[1116, 1385]] 1.0 2yjr TYR_ALK_HUMAN TYR 1.3e-90 309.2 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 6EDLA Q9UM73 1093 1399 1620.0 J4M:1500 Type1 Inactive DFGin 5.7419 13.9986 None -126.77, 7.53 -146.28, 139.77 -129.2, 999.0 286.43, 88.97 999.0, 999.0 in-in in 8.043 Saltbr-in 3.2026 HRD-in -75.33, -45.54 75.3, -3.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -90.79, -15.28 APE9-dihe-in -62.49, 138.06 APE8-dihe-in -76.58, 62.31 APE8-rot-na 33.87 APE67-dihe-in -71.34, -10.1 -42.44, -41.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1154 None None None XRAY 2.799 0.231 0.282 A 322.0 282.0 25 30 14 16 [[1116, 1385]] 1.0 6edl TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5IMXA Q9UM73 1109 1400 1620.0 CZ4:1501 Type1 Inactive DFGin 5.0344 14.4493 None -109.53, -14.09 -148.27, 147.07 -105.7, 146.52 283.91, 86.87 -67.35, -107.72 in-in in 8.0283 Saltbr-in 2.5042 HRD-in -65.65, -55.77 80.57, -2.35 in-out-out SNCioo out-out ActLoopNT-out 7.5579 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.05, -3.8 APE9-dihe-in -82.72, 146.31 APE8-dihe-in -87.12, 68.37 APE8-rot-na 16.28 APE67-dihe-in -69.01, -16.06 -50.43, -36.09 APE12-dist-na 10.9042 APE11-dist-na 15.5625 APE10-dist-na 10.6323 APE9-dist-in 7.972 None None None XRAY 2.12 0.213 0.259 A 327.0 266.0 26 30 20 10 [[1116, 1385]] 1.0 5imx TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.6296 13.8228 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.4822 Saltbr-in 2.8829 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9739 C1097S None None XRAY 2.03 0.211 0.256 A 333.0 288.0 22 30 16 14 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.7474 13.6282 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.5634 Saltbr-in 2.9896 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7127 C1097S None None XRAY 2.03 0.211 0.256 B 333.0 284.0 25 30 15 15 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR AXL UFO_HUMAN 5U6BA P30530 521 813 894.0 7YS:69001 Type1 Inactive DFGin 6.3623 13.5788 None -138.45, -176.55 74.1, -59.44 62.23, 29.92 319.8, 103.87 51.42, 41.79 out-out out 13.7081 Saltbr-out 12.0892 HRD-in -66.09, -54.16 75.27, -12.42 out-out-none SNCoon out-none ActLoopNT-out 9.8826 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -58.78 APE8-rot-na 17.42 APE67-dihe-in -67.55, -5.96 -47.01, -39.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.84 0.212 0.239 A 307.0 270.0 23 30 14 16 [[536, 805]] 1.0 5u6b TYR_AXL_HUMAN TYR 2.8e-92 314.7 2.0 260.0 259.0 689 690 691 693 695 567 585 589 669 671 670 672.0 731 719 714 713 712 711 710 709 708 621 Tyrosine-protein kinase receptor UFO
TYR AXL UFO_HUMAN 5U6BC P30530 521 813 894.0 7YS:69001 Type1 Inactive DFGin 6.4468 13.7913 None -138.61, -175.97 75.83, -59.43 64.34, 25.07 310.35, 105.78 53.72, 41.47 out-out out 13.6127 Saltbr-out 11.748 HRD-in -65.26, -53.97 74.88, -12.45 out-out-none SNCoon out-none ActLoopNT-out 9.6998 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -86.85 APE8-rot-na 343.56 APE67-dihe-in -67.51, -5.95 -41.15, -42.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.84 0.212 0.239 C 307.0 270.0 23 30 14 16 [[536, 805]] 1.0 5u6b TYR_AXL_HUMAN TYR 2.8e-92 314.7 2.0 260.0 259.0 689 690 691 693 695 567 585 589 669 671 670 672.0 731 719 714 713 712 711 710 709 708 621 Tyrosine-protein kinase receptor UFO
TYR BTK BTK_HUMAN 3PIYA Q06187 391 658 659.0 585:1 Type1 Inactive DFGin 6.5898 14.8046 None -86.48, 116.32 -39.12, -55.85 -103.57, 159.77 292.78, 91.05 -55.45, 135.27 out-out out 10.5998 Saltbr-out 6.1662 HRD-in -82.22, -47.83 77.57, -19.27 out-out-out SNCooo out-out ActLoopNT-out 14.1198 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.57, 20.38 APE9-dihe-in -77.53, 136.74 APE8-dihe-in -77.13, 67.95 APE8-rot-na 32.82 APE67-dihe-in -63.75, -20.32 -55.08, -51.26 APE12-dist-na 17.7544 APE11-dist-na 17.7304 APE10-dist-na 12.4391 APE9-dist-out 8.1766 None None None XRAY 2.55 0.228 0.295 A 274.0 262.0 6 29 29 0 [[402, 653]] 1.0 3piy TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3PJ2A Q06187 391 659 659.0 04K:1 Type1.5_Back Inactive DFGin 4.8792 13.7655 None -125.57, -174.91 51.36, 35.37 -74.45, 999.0 30.81, 92.87 999.0, 999.0 out-out out 10.8742 Saltbr-out 6.4644 HRD-in -71.49, -54.79 77.51, -7.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.76 APE8-dihe-in -75.06, 65.46 APE8-rot-na 29.28 APE67-dihe-in -67.05, -14.12 -51.89, -45.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1661 None None None XRAY 1.75 0.231 0.263 A 274.0 248.0 21 29 11 18 [[402, 653]] 1.0 3pj2 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR CSK CSK_HUMAN 3D7TA P41240 188 450 450.0 STU:6335 Type1 Inactive DFGin 4.8478 13.7273 None -129.86, -75.48 -112.49, 120.17 -68.38, 132.53 310.55, 71.3 -108.94, 999.0 in-in in 9.7085 Saltbr-in 3.505 HRD-in -84.81, -41.33 76.65, -6.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.32 APE8-rot-na 27.67 APE67-dihe-in -57.33, -30.65 -43.31, -55.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K361A,K362A None None XRAY 2.899 0.239 0.278 A 269.0 249.0 14 25 11 14 [[195, 442]] 1.0 3d7t TYR_CSK_HUMAN TYR 5.7e-87 297.2 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR EGFR EGFR_HUMAN 4RIWB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9474 14.5093 None -144.94, -140.84 60.54, -94.56 67.75, 16.38 293.55, 125.63 -72.75, -24.64 in-in in 8.962 Saltbr-in 2.5768 HRD-out -81.5, 87.13 -71.92, 10.44 in-in-none SNCiin in-none ActLoopNT-in 2.9141 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.11 APE8-dihe-in -64.72, 105.47 APE8-rot-na 338.81 APE67-dihe-in -78.09, 0.73 -66.98, -35.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3389 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4riw TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIWD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 6.0156 14.3995 None -147.43, -141.55 60.24, -94.38 68.1, 17.38 294.17, 126.48 -72.23, -23.22 in-in in 8.8454 Saltbr-in 3.0814 HRD-in -78.23, -46.1 60.09, 5.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.64, 111.47 APE9-dihe-in -129.74, 134.09 APE8-dihe-in -62.84, 106.17 APE8-rot-na 337.89 APE67-dihe-in -78.37, 3.33 -65.15, -34.97 APE12-dist-na 11.3973 APE11-dist-na 9.9458 APE10-dist-na 9.7227 APE9-dist-in 6.0148 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4riw TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9187 14.5792 None -139.87, -153.46 71.8, -106.42 74.55, 12.91 300.13, 117.16 -73.01, -18.89 in-in in 8.7784 Saltbr-in 2.8507 HRD-out -79.93, 91.22 -73.37, 9.67 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -57.54, 105.82 APE8-rot-na 336.15 APE67-dihe-in -83.65, 5.55 -71.82, -34.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6445 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4rix TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9838 14.3961 None -138.76, -155.76 70.86, -102.17 73.98, 14.44 299.1, 114.44 -71.0, -18.03 in-in in 8.4327 Saltbr-in 2.1297 HRD-in -75.74, -46.31 59.89, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.8788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.43, 115.77 APE9-dihe-in -128.43, 136.25 APE8-dihe-in -57.6, 106.59 APE8-rot-na 335.5 APE67-dihe-in -81.04, 4.3 -70.58, -32.32 APE12-dist-na 11.3356 APE11-dist-na 10.1436 APE10-dist-na 10.4275 APE9-dist-in 5.9873 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4rix TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9519 14.6551 None -154.99, 131.23 -173.19, -76.87 64.96, 12.46 300.69, 132.23 -71.94, -28.32 in-in in 8.6852 Saltbr-in 2.9501 HRD-out -79.99, 96.69 -77.78, 9.7 in-in-none SNCiin in-none ActLoopNT-in 2.8837 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.59 APE8-dihe-in -76.15, 93.2 APE8-rot-na 346.43 APE67-dihe-in -79.33, 6.83 -64.49, -46.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3497 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4riy TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.8922 14.3982 None -146.72, -160.68 90.34, -82.61 63.94, 14.36 297.22, 112.71 -69.53, -27.12 in-in in 8.3332 Saltbr-in 2.3271 HRD-in -73.91, -45.57 61.02, 4.8 in-in-in SNCiii in-in ActLoopNT-in 2.9763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.34, 113.28 APE9-dihe-in -130.38, 137.58 APE8-dihe-in -69.37, 99.85 APE8-rot-na 344.82 APE67-dihe-in -75.56, 6.57 -58.1, -42.52 APE12-dist-na 11.2323 APE11-dist-na 10.2008 APE10-dist-na 9.9606 APE9-dist-in 6.2575 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4riy TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8EMEA P00533 700 1007 1210.0 No_ligand No_ligand Inactive DFGin 3.9857 13.8386 None -137.24, 168.8 64.53, 119.38 -177.18, 999.0 59.37, 99.1 999.0, 999.0 out-out out 13.8892 Saltbr-out 11.3112 HRD-none 999.0, 999.0 999.0, 84.53 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -73.83, -4.04 999.0, -46.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.32 0.285 0.318 A 331.0 267.0 31 30 9 21 [[712, 970]] 1.0 8eme TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GOPA P00533 676 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.9058 14.6185 None -81.86, 151.27 -44.37, 145.0 -81.84, 77.36 22.41, 114.96 178.29, 999.0 in-na in 8.8504 Saltbr-na 999.0 HRD-in -65.46, -52.27 80.15, -7.53 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.74 APE8-dihe-in -83.3, 83.47 APE8-rot-na 22.34 APE67-dihe-in -72.58, -12.26 -49.6, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.954 K745M None None XRAY 2.8 0.213 0.259 A 361.0 300.0 29 30 12 18 [[712, 970]] 1.0 3gop TYR_EGFR_HUMAN TYR 3.2e-86 295.0 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXIB P00533 702 1004 1210.0 8BS:1101 Type1 Inactive DFGin 4.6415 14.267 None -127.65, -24.47 -127.47, 108.69 -144.39, 139.56 46.55, 108.56 -178.57, -134.7 out-out out 13.4169 Saltbr-out 12.2007 HRD-in -66.29, -55.89 76.11, -7.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.37 APE8-dihe-in -80.39, 70.42 APE8-rot-na 30.87 APE67-dihe-in -73.29, -5.7 -53.51, -46.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5111 T790M,V948R None None XRAY 3.0 0.278 0.312 B 331.0 274.0 25 30 13 17 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0C P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 5.7951 16.2132 None -140.43, -171.69 57.16, 56.26 -102.57, 14.47 175.77, 70.43 -64.23, -166.18 out-out out 13.304 Saltbr-out 13.7106 HRD-in -68.5, -58.2 83.04, -5.79 out-out-none SNCoon out-none ActLoopNT-out 7.9551 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.7 APE8-dihe-in -78.4, 79.01 APE8-rot-na 31.55 APE67-dihe-in -75.24, -1.85 -59.7, -43.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5896 T790M,V948R None None XRAY 3.1 0.24 0.292 C 331.0 289.0 19 30 16 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7U98A P00533 701 1007 1210.0 M1O:1101 Type1 Inactive DFGin 5.2916 16.4611 None -131.78, -176.31 58.71, 37.78 -55.07, -79.17 157.63, 65.72 -77.42, -26.86 out-out out 13.9765 Saltbr-out 14.699 HRD-in -68.9, -54.72 82.24, -14.81 out-out-none SNCoon out-none ActLoopNT-out 7.1211 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.12 APE8-rot-na 30.49 APE67-dihe-in -75.19, -1.88 -59.47, -39.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.42 0.216 0.244 A 331.0 287.0 20 30 16 14 [[712, 970]] 1.0 7u98 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7ZYQB P00533 700 984 1210.0 V58:1101 Type1 Inactive DFGin 5.1442 13.2951 None -125.84, 171.99 57.78, 57.18 -116.53, 999.0 63.4, 95.28 999.0, 999.0 out-out out 12.8682 Saltbr-out 9.5455 HRD-in -76.02, -55.26 80.29, -12.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.05 APE8-dihe-in -82.27, 69.03 APE8-rot-na 30.38 APE67-dihe-in -72.67, -5.58 -56.39, -41.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4702 T790M,V948R None None XRAY 2.1 0.199 0.223 B 333.0 260.0 25 30 11 19 [[712, 970]] 1.0 7zyq TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JIVA P00533 700 984 1210.0 HKI:1797 Type1.5_Back Inactive DFGin 5.403 14.133 None -99.08, 179.7 43.08, 110.41 179.69, 142.51 59.42, 1.67 76.47, 0.27 out-out out 13.3964 Saltbr-out 10.1083 HRD-in -70.42, -63.2 89.91, -17.22 out-out-none SNCoon out-none ActLoopNT-out 6.9283 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -38.75 APE9-dihe-in -107.53, 155.69 APE8-dihe-in -72.57, 63.91 APE8-rot-na 32.44 APE67-dihe-in -65.29, 3.74 -54.81, -43.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.9317 APE9-dist-in 7.634 T790M None None XRAY 3.5 0.253 0.284 A 328.0 270.0 15 30 16 14 [[712, 970]] 1.0 2jiv TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 4PDOA P29317 590 875 976.0 No_ligand No_ligand Inactive DFGin 5.3167 14.8536 None -130.75, -10.88 -121.71, 138.39 -133.1, 999.0 295.74, 93.17 999.0, 999.0 in-out in 7.9685 Saltbr-out 6.2618 HRD-in -77.55, -48.01 73.27, -11.62 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.79, 137.86 APE9-dihe-in -135.53, 157.5 APE8-dihe-in -79.41, 83.0 APE8-rot-na 28.9 APE67-dihe-in -59.48, -20.71 -53.52, -46.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4933 None None None XRAY 2.104 0.162 0.184 A 299.0 261.0 25 31 13 18 [[613, 873]] 1.0 4pdo TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 4PDOB P29317 590 875 976.0 No_ligand No_ligand Inactive DFGin 5.2883 14.8974 None -129.53, -11.31 -121.1, 139.25 -134.72, 999.0 294.46, 94.17 999.0, 999.0 in-out in 7.9653 Saltbr-out 6.3734 HRD-in -76.29, -48.44 73.45, -12.19 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.42, 139.51 APE9-dihe-in -133.49, 157.9 APE8-dihe-in -78.68, 83.43 APE8-rot-na 28.65 APE67-dihe-in -60.39, -20.86 -55.6, -45.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4952 None None None XRAY 2.104 0.162 0.184 B 299.0 261.0 25 31 13 18 [[613, 873]] 1.0 4pdo TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5IA1A P29317 605 888 976.0 ZZL:1001 Type1 Inactive DFGin 5.1042 13.4399 None -130.45, -159.4 76.21, -65.85 93.22, -3.68 287.63, 98.57 73.71, -159.39 in-in in 8.8254 Saltbr-in 3.2305 HRD-in -77.12, -51.78 78.89, -19.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.06 APE8-dihe-in -70.6, 101.8 APE8-rot-na 29.53 APE67-dihe-in -68.76, -14.33 -55.26, -45.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7832 None None None XRAY 2.036 0.183 0.223 A 306.0 261.0 23 31 14 17 [[613, 873]] 1.0 5ia1 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOOA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.5698 16.1391 None -130.25, -171.33 69.56, 59.1 -97.35, 999.0 296.3, 100.28 999.0, 999.0 in-in in 8.8441 Saltbr-in 2.1671 HRD-in -71.72, -46.92 71.95, -7.05 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -147.9 APE8-rot-na 327.21 APE67-dihe-in -60.63, -26.51 -52.34, -45.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F,Y742F None None XRAY 1.25 0.19 0.202 A 373.0 273.0 21 31 10 21 [[621, 880]] 1.0 2qoo TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOFA P29320 595 906 983.0 No_ligand No_ligand Inactive DFGin 5.5743 16.1535 None -128.85, -171.0 68.65, 68.64 -106.11, 999.0 294.29, 100.28 999.0, 999.0 in-in in 8.483 Saltbr-in 2.8656 HRD-in -71.61, -47.44 75.56, -15.18 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.26 APE8-rot-na 32.87 APE67-dihe-in -60.72, -24.96 -52.12, -45.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F None None XRAY 1.2 0.182 0.195 A 373.0 280.0 21 31 10 21 [[621, 880]] 1.0 2qof TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QODA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.547 16.0547 None -131.77, -171.54 68.49, 69.41 -105.64, 999.0 292.55, 100.77 999.0, 999.0 in-in in 8.4586 Saltbr-in 2.9771 HRD-in -71.92, -47.0 75.02, -14.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.55 APE8-rot-na 32.64 APE67-dihe-in -61.1, -23.78 -54.99, -44.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y602F None None XRAY 1.15 0.193 0.206 A 373.0 274.0 21 31 10 21 [[621, 880]] 1.0 2qod TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOIA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.6186 16.2562 None -129.96, -173.84 70.71, 70.9 -110.19, 999.0 293.26, 97.85 999.0, 999.0 in-in in 8.9164 Saltbr-in 2.1555 HRD-in -70.57, -48.64 76.1, -13.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.52 APE8-rot-na 29.06 APE67-dihe-in -60.23, -25.5 -51.78, -44.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.25 0.186 0.192 A 373.0 274.0 21 31 10 21 [[621, 880]] 1.0 2qoi TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOLA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.5305 15.9534 None -127.91, -172.59 67.31, 78.66 -111.91, 999.0 291.32, 93.34 999.0, 999.0 in-in in 8.4262 Saltbr-in 3.1155 HRD-in -70.18, -47.4 74.82, -14.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -61.36, -24.47 999.0, -38.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F,S768G None None XRAY 1.07 0.196 0.211 A 373.0 273.0 22 31 9 22 [[621, 880]] 1.0 2qol TYR_EPHA3_HUMAN TYR 3.8e-110 373.3 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4P4CA P29320 613 904 983.0 25Q:1001 Type1 Inactive DFGin 5.4825 15.719 None -128.35, -167.77 63.56, 68.23 -102.55, 999.0 294.45, 99.08 999.0, 999.0 in-in in 8.2617 Saltbr-in 2.859 HRD-in -69.2, -49.45 78.06, -9.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.75 APE8-rot-na 27.6 APE67-dihe-in -61.51, -22.54 -51.34, -46.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.599 0.179 0.202 A 361.0 266.0 21 31 10 21 [[621, 880]] 1.0 4p4c TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHB1 EPHB1_HUMAN 7KPMA P54762 611 888 984.0 ADP:901 ATPlike Inactive DFGin 6.1477 15.077 None -129.01, -161.15 68.81, 56.56 -103.91, 999.0 293.32, 103.77 999.0, 999.0 in-in in 7.7435 Saltbr-in 2.7086 HRD-in -77.02, -45.59 75.58, -13.35 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.94 APE8-rot-na 30.04 APE67-dihe-in -77.93, -6.39 -53.89, -41.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR647 PTR647 XRAY 1.608 0.169 0.197 A 279.0 255.0 23 33 10 23 [[619, 880]] 1.0 7kpm TYR_EPHB1_HUMAN TYR 2.3e-109 370.6 2.0 261.0 260.0 761 762 763 765 767 651 668 672 741 743 742 744.0 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 7KPLA P54762 611 888 984.0 No_ligand No_ligand Inactive DFGin 6.1167 14.504 None -122.5, -147.19 60.66, 72.8 -110.8, 999.0 285.53, 126.95 999.0, 999.0 in-in in 8.7776 Saltbr-in 3.1106 HRD-in -81.07, -50.31 62.2, -0.14 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.78 APE8-dihe-in -69.07, 87.68 APE8-rot-na 25.45 APE67-dihe-in -71.96, -7.05 -54.45, -46.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6029 None PTR647 PTR647 XRAY 2.705 0.202 0.25 A 279.0 256.0 22 33 11 22 [[619, 880]] 1.0 7kpl TYR_EPHB1_HUMAN TYR 2.3e-109 370.6 2.0 261.0 260.0 761 762 763 765 767 651 668 672 741 743 742 744.0 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 6UMWA P54762 611 889 984.0 CTC:901 Type1.5_Back Inactive DFGin 6.0667 14.8859 None -130.77, -142.58 52.4, 64.34 -100.65, 999.0 280.28, 134.37 999.0, 999.0 in-out in 8.9314 Saltbr-out 5.9984 HRD-in -72.73, -48.51 73.38, -14.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.46 APE8-dihe-in -70.84, 88.26 APE8-rot-na 28.98 APE67-dihe-in -78.1, -4.96 -58.23, -45.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7503 None PTR647 PTR647 XRAY 1.982 0.184 0.221 A 301.0 257.0 22 33 11 22 [[619, 880]] 1.0 6umw TYR_EPHB1_HUMAN TYR 3e-109 370.3 2.0 261.0 260.0 761 762 763 765 767 651 668 672 741 743 742 744.0 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB2 EPHB2_HUMAN 3ZFMA P29323 615 894 1055.0 No_ligand No_ligand Inactive DFGin 6.0137 15.5935 None -128.47, -176.09 61.51, 84.25 -111.37, 999.0 299.24, 93.21 999.0, 999.0 in-none in 8.6734 Saltbr-none 999.0 HRD-in -65.39, -46.71 66.95, -12.96 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.31 APE8-rot-na 17.62 APE67-dihe-in -74.85, 1.16 -40.98, -50.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.236 0.263 A 298.0 249.0 31 33 10 23 [[621, 882]] 1.0 3zfm TYR_EPHB2_HUMAN TYR 4.4e-109 369.7 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB3 EPHB3_HUMAN 3ZFYA P54753 632 905 998.0 No_ligand No_ligand Inactive DFGin 5.9131 13.19 None -135.83, 169.47 -155.99, -162.71 44.27, 31.84 325.27, 124.04 -167.07, 999.0 in-out in 8.962 Saltbr-out 5.099 HRD-in -71.74, -46.97 81.22, -17.57 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -13.43 APE9-dihe-in -122.1, 118.82 APE8-dihe-in -85.89, 93.62 APE8-rot-na 31.88 APE67-dihe-in -62.28, -23.15 -49.62, -53.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3289 None None None XRAY 2.2 0.226 0.252 A 298.0 260.0 14 33 25 8 [[633, 894]] 1.0 3zfy TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 3ZFYB P54753 631 905 998.0 No_ligand No_ligand Inactive DFGin 5.9266 13.1757 None -135.57, 169.17 -156.18, -162.85 44.96, 29.53 325.58, 124.75 -172.35, 999.0 in-none in 8.9457 Saltbr-none 999.0 HRD-in -70.36, -48.08 82.24, -17.0 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -16.99 APE9-dihe-in -120.26, 118.85 APE8-dihe-in -85.02, 93.24 APE8-rot-na 32.99 APE67-dihe-in -63.33, -22.58 -50.36, -52.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3566 None None None XRAY 2.2 0.226 0.252 B 298.0 255.0 20 33 25 8 [[633, 894]] 1.0 3zfy TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 5L6OA P54753 632 905 998.0 6P6:1001 Type1 Inactive DFGin 6.3789 12.358 None -136.06, 179.55 -169.33, 167.09 62.02, 34.74 338.03, 114.42 -115.47, -169.51 in-in in 8.878 Saltbr-in 3.5045 HRD-in -65.56, -50.53 79.19, -13.37 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.45, 139.28 APE9-dihe-in -128.33, 129.52 APE8-dihe-in -85.6, 95.79 APE8-rot-na 29.74 APE67-dihe-in -63.86, -27.48 -56.29, -41.16 APE12-dist-na 21.3818 APE11-dist-na 17.7016 APE10-dist-na 13.8374 APE9-dist-in 6.5576 A899P None None XRAY 1.88 0.19 0.206 A 298.0 267.0 7 33 29 4 [[633, 894]] 1.0 5l6o TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 5L6PA P54753 632 905 998.0 6P8:1001 Type1 Inactive DFGin 6.9132 13.5082 None -121.71, 172.7 -177.55, 159.52 60.86, 39.03 330.37, 109.09 -99.35, -138.53 in-out in 8.77 Saltbr-out 3.6125 HRD-in -66.38, -48.41 77.7, -5.2 out-out-in SNCooi out-in ActLoopNT-out 19.8833 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.16, 144.59 APE9-dihe-in -127.94, 122.91 APE8-dihe-in -84.6, 92.12 APE8-rot-na 31.43 APE67-dihe-in -59.89, -19.8 -39.97, -57.64 APE12-dist-na 20.9448 APE11-dist-na 17.4017 APE10-dist-na 14.0235 APE9-dist-in 6.299 A899P None None XRAY 2.26 0.206 0.232 A 298.0 274.0 0 33 33 0 [[633, 894]] 1.0 5l6p TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
TYR EPHB4 EPHB4_HUMAN 2YN8A P54760 608 888 987.0 STU:1889 Type1 Inactive DFGin 6.4266 14.6174 None -130.9, 178.33 70.32, 85.06 -121.95, 999.0 309.1, 102.44 999.0, 999.0 in-in in 7.5327 Saltbr-in 2.7506 HRD-in -74.77, -43.96 71.71, -21.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.38 APE8-rot-na 24.51 APE67-dihe-in -59.12, -26.62 -41.36, -49.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 A 298.0 253.0 28 33 10 23 [[615, 876]] 1.0 2yn8 TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8B P54760 606 888 987.0 STU:1889 Type1 Inactive DFGin 6.4286 14.6268 None -131.1, 178.0 70.17, 85.21 -120.37, 999.0 309.66, 103.01 999.0, 999.0 in-in in 7.4864 Saltbr-in 2.7603 HRD-in -75.37, -48.88 76.16, -20.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.61 APE8-rot-na 24.46 APE67-dihe-in -59.58, -26.36 -40.69, -50.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 B 298.0 260.0 23 33 10 23 [[615, 876]] 1.0 2yn8 TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWUA P54760 609 887 987.0 7X1:1888 Type1 Inactive DFGin 6.0774 15.9237 None -124.83, -150.81 63.15, 75.45 -124.13, 999.0 300.91, 99.28 999.0, 999.0 in-in in 8.0751 Saltbr-in 2.9136 HRD-in -76.46, -48.16 73.47, -11.39 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.21 APE8-dihe-in -73.39, 85.33 APE8-rot-na 28.9 APE67-dihe-in -73.59, -6.79 -48.01, -50.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3579 Y774E None None XRAY 2.0 0.177 0.209 A 302.0 253.0 26 33 11 22 [[615, 876]] 1.0 2vwu TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWVA P54760 606 885 987.0 7X3:1888 Type1 Inactive DFGin 5.9221 15.5979 None -133.23, -172.3 65.63, 73.48 -107.63, 999.0 299.15, 99.0 999.0, 999.0 in-in in 8.5873 Saltbr-in 2.6234 HRD-in -81.9, -48.15 79.25, -19.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 11.23 APE9-dihe-in -83.5, 125.27 APE8-dihe-in -64.05, 86.66 APE8-rot-na 24.68 APE67-dihe-in -70.9, -11.59 -54.32, -49.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6027 Y774E None None XRAY 1.9 0.241 0.287 A 302.0 255.0 25 33 12 21 [[615, 876]] 1.0 2vwv TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWWA P54760 609 887 987.0 7X2:1888 Type1 Inactive DFGin 6.066 15.7518 None -127.97, -175.21 79.12, 85.48 -128.75, 999.0 298.95, 96.97 999.0, 999.0 in-in in 8.0597 Saltbr-in 2.9804 HRD-in -81.76, -48.87 81.8, -14.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.85 APE8-dihe-in -74.53, 86.32 APE8-rot-na 30.17 APE67-dihe-in -77.13, -5.49 -50.75, -49.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3504 Y774E None None XRAY 1.9 0.186 0.229 A 302.0 253.0 26 33 11 22 [[615, 876]] 1.0 2vww TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR ERBB2 ERBB2_HUMAN 7JXHB P04626 707 996 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 7.2065 13.5254 None -148.36, -162.08 75.74, -80.61 60.69, 10.97 304.93, 117.3 -60.45, -19.03 out-out out 11.1459 Saltbr-out 7.1946 HRD-in -68.76, -43.51 73.16, -15.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.14, 8.4 APE9-dihe-in -91.45, 135.42 APE8-dihe-in -59.93, 122.28 APE8-rot-na 333.95 APE67-dihe-in -83.25, -7.59 -73.08, -19.15 APE12-dist-na 999.0 APE11-dist-na 10.876 APE10-dist-na 7.7989 APE9-dist-in 5.3721 None None None XRAY 3.27 0.241 0.285 B 326.0 276.0 14 30 16 14 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHC P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.6125 13.3041 None -143.65, -158.56 73.24, -76.65 56.5, 17.37 306.61, 100.9 -65.36, -26.15 out-out out 11.167 Saltbr-out 8.5521 HRD-in -71.63, -45.71 67.47, -11.62 out-in-out SNCoio in-out ActLoopNT-in 2.8423 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.65, -5.59 APE9-dihe-in -76.55, 128.34 APE8-dihe-in -57.68, 119.14 APE8-rot-na 333.73 APE67-dihe-in -84.4, -5.28 -70.79, -17.96 APE12-dist-na 999.0 APE11-dist-na 10.8294 APE10-dist-na 7.7009 APE9-dist-in 5.3788 None None None XRAY 3.27 0.241 0.285 C 326.0 274.0 12 30 18 12 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHD P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.7679 13.3927 None -142.96, -159.37 73.71, -79.68 58.36, 17.86 306.67, 100.24 -64.62, -26.72 out-out out 11.1303 Saltbr-out 5.9863 HRD-in -71.8, -45.74 66.79, -11.56 out-in-none SNCoin in-none ActLoopNT-in 3.0535 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 8.73 APE9-dihe-in -87.17, 130.9 APE8-dihe-in -61.26, 114.35 APE8-rot-na 332.97 APE67-dihe-in -82.22, -4.18 -69.93, -17.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.7783 APE9-dist-in 5.5184 None None None XRAY 3.27 0.241 0.285 D 326.0 283.0 3 30 27 3 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHF P04626 713 991 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.9028 13.9624 None -147.07, -162.69 78.08, -83.21 56.45, 8.27 300.93, 121.19 -58.9, -10.87 out-out out 10.8692 Saltbr-out 6.7281 HRD-in -63.37, -44.43 70.8, -16.12 out-out-none SNCoon out-none ActLoopNT-out 5.435 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.37 APE8-dihe-in -63.96, 121.3 APE8-rot-na 334.12 APE67-dihe-in -82.97, -7.43 -74.51, -19.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.6423 None None None XRAY 3.27 0.241 0.285 F 326.0 262.0 17 30 18 12 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHG P04626 706 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 7.8697 13.8089 None -142.75, -163.19 75.45, -91.2 64.27, 18.94 302.94, 97.25 -68.06, -26.16 out-out out 11.5789 Saltbr-out 7.4558 HRD-in -69.52, -47.34 66.45, -11.89 out-in-none SNCoin in-none ActLoopNT-in 3.4707 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.01 APE8-dihe-in -53.01, 109.02 APE8-rot-na 332.56 APE67-dihe-in -83.03, -4.37 -69.53, -16.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7907 None None None XRAY 3.27 0.241 0.285 G 326.0 273.0 14 30 16 14 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHH P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.4919 13.3909 None -147.0, -168.64 78.92, -65.16 55.44, -120.37 308.82, 110.24 77.15, -59.63 out-out out 10.4414 Saltbr-out 6.2345 HRD-in -70.56, -45.63 67.17, -12.43 out-in-out SNCoio in-out ActLoopNT-in 2.8816 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.87, 9.88 APE9-dihe-in -95.76, 115.55 APE8-dihe-in -50.25, 109.35 APE8-rot-na 333.22 APE67-dihe-in -82.18, -3.91 -69.96, -16.92 APE12-dist-na 8.8114 APE11-dist-na 10.9517 APE10-dist-na 7.599 APE9-dist-in 5.5459 None None None XRAY 3.27 0.241 0.285 H 326.0 282.0 4 30 30 0 [[720, 978]] 1.0 7jxh TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3PP0A P04626 706 993 1255.0 03Q:1 Type1.5_Back Inactive DFGin 6.1891 12.8909 None -143.24, -161.48 74.0, -72.25 62.71, 12.18 304.07, 105.53 -53.57, -26.07 out-out out 10.8314 Saltbr-out 6.7356 HRD-in -72.52, -43.75 67.05, -6.56 out-in-in SNCoii in-in ActLoopNT-in 2.986 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.93, 133.73 APE9-dihe-in -132.61, 148.93 APE8-dihe-in -81.51, 83.41 APE8-rot-na 32.02 APE67-dihe-in -73.68, -2.45 -53.16, -44.04 APE12-dist-na 999.0 APE11-dist-na 9.4866 APE10-dist-na 9.955 APE9-dist-in 6.4533 M706A,Q711L,M712L None None XRAY 2.25 0.189 0.26 A 338.0 286.0 2 30 28 2 [[720, 978]] 1.0 3pp0 TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3PP0B P04626 706 1009 1255.0 03Q:2 Type1.5_Back Inactive DFGin 6.5295 13.1712 None -149.09, -166.81 85.39, -78.34 67.1, 11.91 301.66, 109.6 -51.94, -39.66 out-out out 10.6441 Saltbr-out 6.7399 HRD-in -69.4, -53.62 79.07, -10.52 out-in-out SNCoio in-out ActLoopNT-in 2.8388 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.46, -6.75 APE9-dihe-in -77.94, 120.44 APE8-dihe-in -61.24, 120.47 APE8-rot-na 332.74 APE67-dihe-in -74.13, -7.61 -67.24, -26.94 APE12-dist-na 999.0 APE11-dist-na 10.6587 APE10-dist-na 7.6218 APE9-dist-in 5.3485 M706A,Q711L,M712L None None XRAY 2.25 0.189 0.26 B 338.0 296.0 2 30 28 2 [[720, 978]] 1.0 3pp0 TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3RCDA P04626 713 1022 1255.0 03P:69001 Type1.5_Back Inactive DFGin 7.3275 12.7836 None -131.6, -178.33 92.87, -78.83 17.87, 80.88 36.71, 96.9 175.62, 84.65 out-out out 12.7748 Saltbr-out 10.1037 HRD-in -81.36, -50.25 83.34, -29.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 32.08 APE8-dihe-in -80.8, 92.84 APE8-rot-na 32.85 APE67-dihe-in -72.62, -9.61 -71.44, -35.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7735 None None None XRAY 3.21 0.227 0.294 A 338.0 278.0 21 30 13 17 [[720, 978]] 1.0 3rcd TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3RCDC P04626 713 1022 1255.0 03P:69001 Type1.5_Back Inactive DFGin 7.2988 12.8076 None -129.48, -177.14 93.53, -78.44 17.53, 81.66 36.39, 96.61 174.11, 84.1 out-out out 12.7623 Saltbr-out 10.1811 HRD-in -79.56, -52.25 82.81, -26.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 30.75 APE8-dihe-in -78.7, 91.19 APE8-rot-na 32.27 APE67-dihe-in -71.69, -11.86 -69.94, -35.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6837 None None None XRAY 3.21 0.227 0.294 C 338.0 278.0 21 30 13 17 [[720, 978]] 1.0 3rcd TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR FGFR1 FGFR1_HUMAN 4F65A P11362 464 765 822.0 0S9:808 Type1 Inactive DFGin 5.6218 13.0799 None -116.38, 166.24 56.16, 50.99 -96.21, 999.0 35.52, 82.62 999.0, 999.0 in-in in 7.9758 Saltbr-in 2.9248 HRD-in -64.44, -52.01 69.63, -13.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.26, 142.02 APE9-dihe-in -87.5, 110.31 APE8-dihe-out -50.81, -23.5 APE8-rot-na 336.61 APE67-dihe-in -69.73, -13.19 -59.55, -23.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.803 C488A,C584S None None XRAY 2.26 0.204 0.235 A 309.0 279.0 23 30 20 10 [[478, 756]] 1.0 4f65 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4NKAB P11362 458 765 822.0 2K7:803 Type1 Inactive DFGin 4.9928 12.588 None -113.09, 172.85 51.3, 36.02 -81.11, 999.0 51.02, 79.07 999.0, 999.0 in-in in 7.7205 Saltbr-in 2.8187 HRD-in -68.57, -53.53 79.69, -21.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -99.94, 158.4 APE9-dihe-in -98.99, 111.75 APE8-dihe-out -53.76, -24.39 APE8-rot-na 331.5 APE67-dihe-in -68.26, -7.43 -55.44, -26.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.4239 C488A,C584S None None XRAY 2.19 0.2 0.228 B 309.0 287.0 21 30 24 6 [[478, 756]] 1.0 4nka TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4F65B P11362 460 763 822.0 0S9:808 Type1.5_Back Inactive DFGin 6.1724 11.7443 None -112.37, 28.01 -137.92, 136.63 -123.39, 999.0 315.19, 98.45 999.0, 999.0 in-in in 7.9279 Saltbr-in 2.9079 HRD-in -72.51, -42.53 62.62, -12.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.78, 143.47 APE9-dihe-in -85.99, 110.74 APE8-dihe-out -51.4, -22.91 APE8-rot-na 337.29 APE67-dihe-in -68.78, -13.01 -59.73, -24.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2572 C488A,C584S None None XRAY 2.26 0.204 0.235 B 309.0 279.0 25 30 23 7 [[478, 756]] 1.0 4f65 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6C18B P11362 466 762 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.466 13.1559 None -121.52, 157.51 52.39, 50.92 -96.25, 999.0 51.2, 88.67 999.0, 999.0 in-in in 8.0231 Saltbr-in 2.9239 HRD-in -68.59, -52.77 77.43, -7.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.06 APE8-rot-na 331.63 APE67-dihe-in -71.45, -6.87 -51.83, -28.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 B 311.0 255.0 42 30 10 20 [[478, 756]] 1.0 6c18 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6MZWB P11362 463 762 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.2433 13.1911 None -113.61, 162.19 59.99, 41.93 -84.77, 999.0 49.28, 82.5 999.0, 999.0 in-in in 7.816 Saltbr-in 2.6843 HRD-in -70.89, -55.55 82.9, -7.56 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-na 29.6 APE67-dihe-in -68.26, -6.41 -48.51, -43.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 B 311.0 258.0 42 30 10 20 [[478, 756]] 1.0 6mzw TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 8U1FB P21802 472 765 821.0 UIM:802 Type1.5_Back Inactive DFGin 6.244 12.7017 None -124.83, 24.9 -143.72, 116.95 -174.75, 141.2 47.25, 98.48 -120.17, -141.34 in-out in 7.1789 Saltbr-out 5.4704 HRD-out -91.63, 125.64 -83.89, -44.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.43 APE8-dihe-in -82.13, 67.06 APE8-rot-na 35.42 APE67-dihe-in -61.84, -12.32 -56.83, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2015 None None None XRAY 3.33 0.269 0.295 B 316.0 268.0 26 30 14 16 [[481, 759]] 1.0 8u1f TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8STGB P21802 472 765 821.0 WCJ:801 Type1.5_Back Inactive DFGin 5.7481 12.473 None -146.69, 51.17 -166.05, 99.26 -159.05, 129.25 42.24, 92.9 -129.91, 121.06 in-out in 7.5175 Saltbr-out 4.9612 HRD-out -109.82, 96.26 -71.43, -48.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 71.23, -15.79 APE9-dihe-in -138.41, 153.88 APE8-dihe-in -76.95, 77.58 APE8-rot-na 30.06 APE67-dihe-in -68.25, -27.71 -60.57, -41.19 APE12-dist-na 23.5958 APE11-dist-na 24.2264 APE10-dist-na 21.8134 APE9-dist-in 7.3025 None None None XRAY 3.79 0.307 0.311 B 317.0 274.0 20 30 20 10 [[481, 759]] 1.0 8stg TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 9U3NB P21802 470 764 821.0 A1ENT:801 Type1.5_Back Inactive DFGin 5.7614 12.952 None -150.15, 37.07 -124.69, 18.17 -79.98, -34.12 48.54, 88.69 -70.14, 999.0 in-in in 7.9398 Saltbr-in 3.3774 HRD-out -109.06, 108.36 -99.86, 137.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -159.89, 170.93 APE9-dihe-in -97.33, 137.9 APE8-dihe-in -78.65, 61.34 APE8-rot-na 34.6 APE67-dihe-in -58.88, -28.65 -55.23, -53.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6586 V564F None None XRAY 3.25 0.283 0.342 B 311.0 272.0 23 30 17 13 [[481, 759]] 1.0 9u3n TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR4 FGFR4_HUMAN 4TYEA P22455 451 753 802.0 No_ligand No_ligand Inactive DFGin 5.829 12.5802 None -91.65, -29.21 -103.02, 104.95 -71.18, -26.95 65.53, 79.96 94.73, -139.66 in-in in 8.2669 Saltbr-in 2.6135 HRD-out -120.78, 153.56 -67.42, -42.5 in-out-out SNCioo out-out ActLoopNT-out 8.3844 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.01 APE8-dihe-in -80.96, 75.64 APE8-rot-na 33.57 APE67-dihe-in -64.71, -19.07 -60.12, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.1877 None None None XRAY 2.8 0.227 0.278 A 311.0 292.0 11 30 23 7 [[467, 745]] 1.0 4tye TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.0214 13.2508 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.3097 Saltbr-out 4.2744 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5xfj TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.2509 13.8003 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.9065 Saltbr-in 3.5618 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.5407 V550L None None XRAY 2.7 0.27 0.32 A 311.0 269.0 29 30 13 17 [[467, 745]] 1.0 5xff TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.4149 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.7877 Saltbr-in 2.7483 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4055 None None None XRAY 2.352 0.237 0.277 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5jkg TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR HCK HCK_HUMAN 3VS0A P08631 81 526 526.0 VS0:60602 Type1 Inactive DFGin 5.5705 16.6537 None -129.57, 162.1 -82.47, -42.29 67.42, 124.57 160.77, 70.48 69.5, 30.08 out-out out 14.2453 Saltbr-out 14.6605 HRD-in -88.57, -37.73 75.77, -11.97 out-out-none SNCoon out-none ActLoopNT-out 7.1153 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.1 APE8-rot-na 22.57 APE67-dihe-in -68.2, -25.74 -107.06, -1.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.934 0.295 0.295 A 454.0 428.0 13 29 16 13 [[262, 513]] 1.0 3vs0 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS0B P08631 81 526 526.0 VS0:60602 Type1 Inactive DFGin 6.0642 17.1807 None -111.8, 150.48 -110.07, -32.77 65.61, 113.92 163.11, 68.65 100.74, -23.61 out-out out 14.2153 Saltbr-out 14.3341 HRD-in -78.42, -39.25 73.05, -7.55 out-out-none SNCoon out-none ActLoopNT-out 6.5568 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.88 APE8-rot-na 26.41 APE67-dihe-in -67.85, -25.96 -92.49, -6.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.934 0.295 0.295 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs0 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS1B P08631 81 526 526.0 VSA:60602 Type1 Inactive DFGin 6.7322 16.9114 None -77.82, 121.43 -54.05, 124.88 82.63, -74.78 150.57, 57.75 -49.96, -36.41 out-out out 14.0072 Saltbr-out 14.3647 HRD-in -101.3, -38.37 77.41, -41.31 out-out-none SNCoon out-none ActLoopNT-out 6.7331 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.85 APE8-rot-na 30.48 APE67-dihe-in -65.84, -20.55 -144.01, -39.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.464 0.281 0.281 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs1 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS2B P08631 81 526 526.0 VSB:60601 Type1 Inactive DFGin 4.1152 13.5671 None -172.86, 118.27 -95.57, 158.0 70.94, 64.18 175.32, 32.25 108.45, -126.49 out-out out 14.0308 Saltbr-out 15.5528 HRD-in -134.11, -48.57 73.0, -14.11 out-out-none SNCoon out-none ActLoopNT-out 7.3664 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.96 APE8-rot-na 32.11 APE67-dihe-in -73.24, -13.59 -122.47, 3.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.609 0.279 0.279 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs2 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS7A P08631 81 526 526.0 KS1:60601 Type1 Inactive DFGin 6.7194 17.468 None -90.49, -125.14 -63.27, 78.08 -85.63, 139.18 138.5, 78.54 73.41, 14.52 out-out out 12.6896 Saltbr-out 12.695 HRD-in -99.39, -35.83 68.71, -16.04 out-out-none SNCoon out-none ActLoopNT-out 7.1153 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.21 APE8-rot-na 27.98 APE67-dihe-in -66.27, -13.07 -124.75, -5.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.001 0.29 0.29 A 454.0 432.0 14 29 15 14 [[262, 513]] 1.0 3vs7 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS1A P08631 81 526 526.0 VSA:60602 Type1.5_Back Inactive DFGin 6.3901 17.1455 None -69.87, 118.45 -52.39, 130.08 95.26, -49.41 153.54, 67.46 -76.6, -8.56 out-out out 13.1819 Saltbr-out 15.1558 HRD-in -89.48, -44.64 76.16, -14.14 out-out-none SNCoon out-none ActLoopNT-out 6.893 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.94 APE8-rot-na 32.7 APE67-dihe-in -65.2, -12.86 -62.99, -17.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.464 0.281 0.281 A 454.0 424.0 13 29 16 13 [[262, 513]] 1.0 3vs1 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 1JQHA P08069 984 1286 1367.0 ANP:301 ATPlike Inactive DFGin 5.6898 16.5691 None -66.7, 163.88 -59.45, 151.32 -140.18, 178.07 43.94, 89.38 -106.76, 173.06 in-out in 9.9768 Saltbr-out 6.0561 HRD-in -50.88, -56.96 74.77, -3.78 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.24, 106.81 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -78.96, 121.64 APE8-rot-na 37.96 APE67-dihe-in -60.45, -7.73 -52.46, -43.95 APE12-dist-na 7.1567 APE11-dist-na 11.2997 APE10-dist-na 15.5969 APE9-dist-in 5.8 E979G,Y980S None None XRAY 2.1 0.195 0.219 A 308.0 291.0 12 30 23 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHB P08069 984 1286 1367.0 ANP:302 ATPlike Inactive DFGin 5.6866 16.5538 None -65.78, 164.4 -59.98, 151.89 -140.81, 178.2 43.68, 89.42 -109.69, -174.77 in-out in 9.9884 Saltbr-out 6.0195 HRD-in -51.69, -56.66 74.32, -2.97 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.6, 107.67 APE9-dihe-in -58.75, 135.36 APE8-dihe-in -79.54, 122.52 APE8-rot-na 37.69 APE67-dihe-in -59.25, -7.46 -52.18, -45.28 APE12-dist-na 6.8166 APE11-dist-na 10.9316 APE10-dist-na 15.2162 APE9-dist-in 5.768 E979G,Y980S None None XRAY 2.1 0.195 0.219 B 308.0 287.0 16 30 23 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHC P08069 984 1286 1367.0 ANP:303 ATPlike Inactive DFGin 5.6976 16.5582 None -65.47, 162.73 -58.75, 151.62 -140.8, 179.03 43.87, 88.98 -110.24, -177.72 in-out in 9.9987 Saltbr-out 6.0347 HRD-in -53.2, -57.0 74.59, -2.63 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.9, 107.89 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -79.04, 122.75 APE8-rot-na 38.27 APE67-dihe-in -60.34, -8.42 -53.61, -43.61 APE12-dist-na 6.9265 APE11-dist-na 10.9862 APE10-dist-na 15.2452 APE9-dist-in 5.7735 E979G,Y980S None None XRAY 2.1 0.195 0.219 C 308.0 291.0 12 30 23 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3QQUB P08069 988 1286 1367.0 01P:60001 Type1 Inactive DFGin 7.3126 15.8493 None -33.42, 160.47 -37.99, 116.49 -33.99, 105.39 285.12, 147.4 61.19, -16.27 in-out in 9.1403 Saltbr-out 5.1324 HRD-out -74.87, 134.07 -112.64, 23.07 out-out-in SNCooi out-in ActLoopNT-out 16.4502 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.73, 125.53 APE9-dihe-in -129.43, 153.07 APE8-dihe-in -94.91, 67.38 APE8-rot-na 36.24 APE67-dihe-in -82.46, 4.52 -51.63, -28.48 APE12-dist-na 20.8733 APE11-dist-na 16.3058 APE10-dist-na 12.6306 APE9-dist-in 7.0517 None None None XRAY 2.9 0.273 0.302 B 301.0 288.0 11 30 30 0 [[999, 1268]] 1.0 3qqu TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3QQUD P08069 989 1285 1367.0 01P:60001 Type1 Inactive DFGin 7.8652 16.3418 None -72.27, 173.4 -41.63, 112.37 -69.49, 2.91 294.86, 82.49 -113.94, 14.31 in-out in 9.3296 Saltbr-out 4.3315 HRD-out -89.46, 130.4 -100.59, 1.17 out-out-out SNCooo out-out ActLoopNT-out 17.3649 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 71.55, 69.22 APE9-dihe-in -124.37, 159.91 APE8-dihe-in -89.12, 68.21 APE8-rot-na 38.62 APE67-dihe-in -73.08, -17.7 -59.12, -27.53 APE12-dist-na 21.9404 APE11-dist-na 19.125 APE10-dist-na 15.1883 APE9-dist-in 7.4577 None None None XRAY 2.9 0.273 0.302 D 301.0 292.0 5 30 30 0 [[999, 1268]] 1.0 3qqu TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 4D2RA P08069 985 1286 1367.0 DYK:2288 Type1 Inactive DFGin 6.1705 16.2033 None -69.68, 163.13 -53.49, 135.63 -66.9, 144.51 304.26, 163.38 61.31, 29.83 out-out out 10.2666 Saltbr-out 6.6469 HRD-in -70.04, -49.33 73.87, -13.98 out-out-in SNCooi out-in ActLoopNT-out 17.4892 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.92, 112.08 APE9-dihe-in -125.82, 147.19 APE8-dihe-in -85.98, 69.81 APE8-rot-na 32.75 APE67-dihe-in -73.08, -8.74 -50.8, -35.19 APE12-dist-na 21.9009 APE11-dist-na 17.0339 APE10-dist-na 13.4169 APE9-dist-in 7.156 None None None XRAY 2.1 0.181 0.221 A 302.0 300.0 2 30 28 2 [[999, 1268]] 1.0 4d2r TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW5A P08069 985 1286 1367.0 LGX:60001 Type1 Inactive DFGin 6.6959 16.8864 None -72.74, 167.89 -46.3, 134.17 -70.68, 160.99 291.97, 0.43 38.79, 22.82 out-out out 10.246 Saltbr-out 5.6112 HRD-in -64.28, -52.64 77.7, -10.43 out-out-in SNCooi out-in ActLoopNT-out 16.5593 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.81, 115.11 APE9-dihe-in -124.48, 143.18 APE8-dihe-in -78.32, 63.38 APE8-rot-na 28.02 APE67-dihe-in -71.11, -14.08 -47.07, -38.36 APE12-dist-na 20.2949 APE11-dist-na 16.0987 APE10-dist-na 12.81 APE9-dist-in 7.3623 None None None XRAY 2.14 0.196 0.254 A 307.0 302.0 0 30 30 0 [[999, 1268]] 1.0 3nw5 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW6A P08069 986 1286 1367.0 LGW:60001 Type1 Inactive DFGin 6.3789 16.3293 None -74.88, 163.27 -46.43, 132.32 -66.66, 145.01 298.3, 172.57 60.37, 24.67 out-out out 10.1158 Saltbr-out 5.223 HRD-in -71.12, -48.14 76.3, -15.79 out-out-in SNCooi out-in ActLoopNT-out 18.2237 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.0, 97.67 APE9-dihe-in -118.49, 154.77 APE8-dihe-in -81.27, 69.63 APE8-rot-na 32.94 APE67-dihe-in -72.42, -10.33 -48.22, -40.81 APE12-dist-na 17.1631 APE11-dist-na 16.7091 APE10-dist-na 13.6552 APE9-dist-in 7.1707 None None None XRAY 2.2 0.184 0.253 A 307.0 301.0 0 30 30 0 [[999, 1268]] 1.0 3nw6 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW7A P08069 987 1286 1367.0 LGV:60001 Type1 Inactive DFGin 5.9142 15.618 None -79.79, -167.52 -73.83, 143.18 -76.01, 139.22 303.93, 155.83 55.33, 50.19 in-out in 9.9504 Saltbr-out 6.8309 HRD-in -73.07, -47.61 73.35, -7.71 out-out-in SNCooi out-in ActLoopNT-out 15.5758 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.1, 112.82 APE9-dihe-in -110.42, 135.27 APE8-dihe-in -85.88, 69.94 APE8-rot-na 27.32 APE67-dihe-in -72.04, -10.86 -50.71, -38.46 APE12-dist-na 999.0 APE11-dist-na 15.9259 APE10-dist-na 11.7944 APE9-dist-in 7.4664 None None None XRAY 2.11 0.168 0.226 A 307.0 297.0 3 30 27 3 [[999, 1268]] 1.0 3nw7 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXQA P08069 980 1286 1367.0 GD5:62287 Type1 Inactive DFGin 6.1499 16.3952 None -75.24, 161.17 -49.54, 127.03 -61.92, 123.0 295.29, 167.93 87.57, 25.79 out-out out 10.4916 Saltbr-out 7.9238 HRD-in -76.32, -54.31 77.35, -9.89 out-out-in SNCooi out-in ActLoopNT-out 15.0638 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.4, 114.95 APE9-dihe-in -123.96, 146.04 APE8-dihe-in -82.98, 67.94 APE8-rot-na 28.97 APE67-dihe-in -76.69, -10.66 -53.34, -32.39 APE12-dist-na 999.0 APE11-dist-na 16.72 APE10-dist-na 13.0321 APE9-dist-in 7.1477 None None None XRAY 2.3 999.0 0.275 A 308.0 301.0 6 30 27 3 [[999, 1268]] 1.0 5fxq TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXRA P08069 980 1283 1367.0 8LN:62284 Type1 Inactive DFGin 6.3636 16.559 None -71.13, 158.45 -48.25, 129.23 -64.15, 116.2 296.93, 166.85 93.0, 19.74 out-out out 10.5392 Saltbr-out 7.1761 HRD-in -75.83, -55.57 82.75, -12.94 out-out-in SNCooi out-in ActLoopNT-out 15.2577 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.77, 112.68 APE9-dihe-in -129.53, 148.37 APE8-dihe-in -86.54, 69.56 APE8-rot-na 33.95 APE67-dihe-in -74.34, -9.8 -55.93, -31.36 APE12-dist-na 999.0 APE11-dist-na 17.4552 APE10-dist-na 13.7499 APE9-dist-in 7.2423 None None None XRAY 2.4 0.23 0.294 A 308.0 299.0 4 30 27 3 [[999, 1268]] 1.0 5fxr TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3I81A P08069 985 1286 1367.0 EBI:60201 Type1 Inactive DFGin 6.6881 15.7829 None -69.56, 174.65 -71.05, 142.28 -76.41, 136.92 311.88, 126.84 70.68, 14.21 out-out out 10.2163 Saltbr-out 5.6184 HRD-in -62.27, -48.86 72.23, -18.63 out-out-none SNCoon out-none ActLoopNT-out 16.9754 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -54.18 APE9-dihe-in -126.35, 139.61 APE8-dihe-in -88.27, 72.05 APE8-rot-na 24.95 APE67-dihe-in -71.45, -14.34 -46.11, -40.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 15.8738 APE9-dist-in 7.2996 None None None XRAY 2.08 0.221 0.265 A 315.0 296.0 6 30 25 5 [[999, 1268]] 1.0 3i81 TYR_IGF1R_HUMAN TYR 2.1e-95 324.9 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXSA P08069 980 1286 1367.0 OZN:62290 Type1 Inactive DFGin 6.3013 16.4608 None -84.33, 164.5 -49.68, 126.88 -62.59, 125.5 294.84, 163.97 82.66, 11.86 out-none out 10.1503 Saltbr-none 999.0 HRD-in -72.06, -52.4 79.12, -11.09 none-out-in SNCnoi out-in ActLoopNT-out 14.946 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.25, 115.64 APE9-dihe-in -119.16, 145.07 APE8-dihe-in -79.78, 69.43 APE8-rot-na 32.71 APE67-dihe-in -75.57, -9.31 -55.8, -33.39 APE12-dist-na 18.9108 APE11-dist-na 16.7981 APE10-dist-na 13.3529 APE9-dist-in 6.9323 None None None XRAY 1.9 0.183 0.214 A 308.0 307.0 0 30 30 0 [[999, 1268]] 1.0 5fxs TYR_IGF1R_HUMAN TYR 6.9e-95 323.2 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3D94A P08069 986 1285 1367.0 D94:60001 Type1.5_Front Inactive DFGin 5.7529 12.0902 None -113.77, -141.33 -41.63, 115.12 -104.14, 0.25 54.89, 83.46 -78.61, -17.4 out-out out 11.0351 Saltbr-out 11.2816 HRD-in -72.35, -49.36 78.31, -12.49 out-out-in SNCooi out-in ActLoopNT-out 9.2573 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.21, 135.68 APE9-dihe-in -120.98, 133.2 APE8-dihe-in -80.59, 66.97 APE8-rot-na 24.88 APE67-dihe-in -76.95, -9.87 -55.9, -29.5 APE12-dist-na 12.6456 APE11-dist-na 8.5957 APE10-dist-na 6.4562 APE9-dist-in 7.1111 None None MHO1142 XRAY 2.3 0.2 0.236 A 301.0 289.0 11 30 30 0 [[999, 1268]] 1.0 3d94 TYR_IGF1R_HUMAN TYR 3.2e-95 324.3 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIAAA P08069 986 1286 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.1834 12.5096 None -115.76, -140.08 -56.69, 128.49 -118.25, -19.27 59.93, 80.29 -40.9, -38.76 out-out out 10.5805 Saltbr-out 8.1365 HRD-in -71.36, -56.99 87.46, -13.56 out-out-none SNCoon out-none ActLoopNT-out 8.9222 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 111.18 APE9-dihe-in -126.65, 126.64 APE8-dihe-in -81.12, 76.62 APE8-rot-na 35.9 APE67-dihe-in -71.26, -20.53 -54.98, -37.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.1722 APE9-dist-in 7.0729 None None None XRAY 3.06 0.193 0.235 AAA 321.0 288.0 13 30 25 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIBBB P08069 986 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2198 12.4468 None -115.29, -140.05 -57.59, 130.35 -119.47, -19.04 57.6, 81.65 -39.33, -40.51 out-out out 10.5812 Saltbr-out 8.1383 HRD-in -71.54, -57.15 87.92, -15.23 out-out-none SNCoon out-none ActLoopNT-out 8.9933 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.31 APE9-dihe-in -126.67, 128.52 APE8-dihe-in -80.09, 76.32 APE8-rot-na 35.62 APE67-dihe-in -70.72, -20.09 -56.2, -36.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.1097 APE9-dist-in 7.0678 None None None XRAY 3.06 0.193 0.235 BBB 321.0 287.0 13 30 25 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYICCC P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.1658 12.5055 None -114.85, -140.89 -57.29, 129.65 -118.38, -19.22 58.71, 80.33 -40.35, -39.19 out-out out 10.5475 Saltbr-out 8.0781 HRD-in -70.97, -56.86 87.86, -15.93 out-out-in SNCooi out-in ActLoopNT-out 8.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -146.69, 116.05 APE9-dihe-in -129.59, 126.27 APE8-dihe-in -80.63, 76.08 APE8-rot-na 36.39 APE67-dihe-in -71.13, -19.68 -54.93, -37.06 APE12-dist-na 999.0 APE11-dist-na 9.6528 APE10-dist-na 6.1837 APE9-dist-in 7.1311 None None None XRAY 3.06 0.193 0.235 CCC 321.0 286.0 13 30 25 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIDDD P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2193 12.4591 None -115.04, -139.19 -57.22, 129.11 -118.66, -19.63 58.67, 81.12 -40.31, -39.48 out-out out 10.6051 Saltbr-out 8.0953 HRD-in -71.24, -57.12 86.84, -13.26 out-out-in SNCooi out-in ActLoopNT-out 8.9353 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.29, 122.24 APE9-dihe-in -125.14, 125.87 APE8-dihe-in -79.9, 75.59 APE8-rot-na 36.0 APE67-dihe-in -70.95, -19.69 -56.73, -36.41 APE12-dist-na 999.0 APE11-dist-na 9.5534 APE10-dist-na 5.9864 APE9-dist-in 7.1246 None None None XRAY 3.06 0.193 0.235 DDD 321.0 287.0 12 30 26 4 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIEEE P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2696 12.4395 None -115.61, -138.87 -56.86, 128.87 -118.49, -19.41 58.83, 81.0 -40.15, -38.87 out-out out 10.5158 Saltbr-out 8.0918 HRD-in -71.39, -56.94 87.82, -14.48 out-out-none SNCoon out-none ActLoopNT-out 8.9511 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 116.42 APE9-dihe-in -125.67, 127.35 APE8-dihe-in -81.15, 76.83 APE8-rot-na 35.52 APE67-dihe-in -70.81, -19.39 -56.95, -36.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.1552 APE9-dist-in 7.1131 None None None XRAY 3.06 0.193 0.235 EEE 321.0 285.0 14 30 24 6 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIFFF P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.3096 12.5061 None -114.84, -139.12 -57.32, 129.09 -119.24, -19.1 58.43, 80.95 -39.6, -40.34 out-out out 10.5617 Saltbr-out 8.089 HRD-in -71.51, -57.69 87.61, -14.16 out-out-in SNCooi out-in ActLoopNT-out 8.9132 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -146.97, 119.39 APE9-dihe-in -127.92, 126.81 APE8-dihe-in -81.17, 76.54 APE8-rot-na 34.85 APE67-dihe-in -70.74, -20.02 -56.2, -36.99 APE12-dist-na 14.2666 APE11-dist-na 9.7045 APE10-dist-na 6.1759 APE9-dist-in 7.0714 None None None XRAY 3.06 0.193 0.235 FFF 321.0 287.0 12 30 27 3 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIGGG P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2153 12.4108 None -115.39, -138.9 -56.85, 128.81 -118.89, -19.11 58.65, 81.01 -40.57, -39.34 out-out out 10.5825 Saltbr-out 8.1508 HRD-in -71.45, -56.87 87.79, -13.89 out-out-none SNCoon out-none ActLoopNT-out 8.956 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.56 APE9-dihe-in -139.88, 129.5 APE8-dihe-in -81.92, 78.52 APE8-rot-na 36.73 APE67-dihe-in -71.48, -19.02 -54.63, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.3133 APE9-dist-in 6.9254 None None None XRAY 3.06 0.193 0.235 GGG 321.0 284.0 15 30 24 6 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIHHH P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2008 12.4942 None -116.04, -140.1 -57.52, 129.83 -118.81, -19.1 57.82, 80.84 -40.32, -39.43 out-out out 10.6159 Saltbr-out 8.1215 HRD-in -71.69, -57.04 87.53, -14.25 out-out-none SNCoon out-none ActLoopNT-out 8.9588 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.91 APE9-dihe-in -126.66, 127.03 APE8-dihe-in -79.81, 75.92 APE8-rot-na 35.31 APE67-dihe-in -70.25, -19.75 -57.25, -36.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.1541 APE9-dist-in 7.1652 None None None XRAY 3.06 0.193 0.235 HHH 321.0 285.0 14 30 25 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNA P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5233 11.883 None -122.71, -134.04 -48.48, 117.08 -112.65, 5.39 56.52, 89.56 -80.2, -12.63 out-out out 10.1046 Saltbr-out 7.0696 HRD-in -68.72, -44.68 74.42, -15.27 out-out-in SNCooi out-in ActLoopNT-out 9.0816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 129.26 APE9-dihe-in -125.1, 113.12 APE8-dihe-in -76.3, 72.6 APE8-rot-na 31.29 APE67-dihe-in -71.82, -14.27 -59.77, -33.09 APE12-dist-na 12.7798 APE11-dist-na 9.3406 APE10-dist-na 6.0029 APE9-dist-in 7.4125 E1097A,E1099A None None XRAY 2.2 0.195 0.218 A 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNB P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.6676 11.6982 None -120.23, -145.7 -34.99, 114.07 -109.86, 7.02 53.42, 94.67 -86.81, -17.85 out-out out 10.2303 Saltbr-out 7.469 HRD-in -74.79, -42.86 77.21, -19.92 out-out-in SNCooi out-in ActLoopNT-out 8.9724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.8, 127.36 APE9-dihe-in -126.61, 120.91 APE8-dihe-in -82.51, 72.5 APE8-rot-na 31.18 APE67-dihe-in -70.34, -12.61 -56.19, -36.04 APE12-dist-na 12.7105 APE11-dist-na 9.4364 APE10-dist-na 6.0092 APE9-dist-in 7.4127 E1097A,E1099A None None XRAY 2.2 0.195 0.218 B 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNC P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5039 11.8927 None -117.5, -144.25 -35.28, 118.67 -116.54, 5.75 57.58, 87.45 -83.77, -13.7 out-out out 10.2048 Saltbr-out 6.5682 HRD-in -68.11, -52.05 81.72, -11.87 out-out-in SNCooi out-in ActLoopNT-out 8.9794 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.64, 128.06 APE9-dihe-in -121.48, 117.98 APE8-dihe-in -78.81, 67.18 APE8-rot-na 28.39 APE67-dihe-in -73.45, -14.3 -52.08, -33.81 APE12-dist-na 13.0318 APE11-dist-na 9.428 APE10-dist-na 6.062 APE9-dist-in 7.2753 E1097A,E1099A None None XRAY 2.2 0.195 0.218 C 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZND P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5858 11.8119 None -120.23, -138.34 -41.88, 115.18 -111.54, 6.87 52.55, 90.98 -80.5, -21.29 out-out out 10.1558 Saltbr-out 7.0568 HRD-in -75.17, -45.42 77.74, -21.01 out-out-in SNCooi out-in ActLoopNT-out 9.0982 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.35, 128.86 APE9-dihe-in -120.46, 118.5 APE8-dihe-in -79.97, 71.37 APE8-rot-na 32.37 APE67-dihe-in -73.39, -13.02 -52.14, -35.35 APE12-dist-na 13.1787 APE11-dist-na 9.2529 APE10-dist-na 6.0206 APE9-dist-in 7.4528 E1097A,E1099A None None XRAY 2.2 0.195 0.218 D 304.0 304.0 0 30 30 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNE P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5339 11.8843 None -122.97, -133.9 -50.03, 120.11 -115.89, 7.06 56.85, 84.61 -81.92, -13.97 out-out out 10.0903 Saltbr-out 7.0006 HRD-in -71.62, -46.82 77.23, -15.08 out-out-in SNCooi out-in ActLoopNT-out 9.0762 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.35, 128.61 APE9-dihe-in -123.88, 113.86 APE8-dihe-in -76.92, 69.0 APE8-rot-na 31.9 APE67-dihe-in -73.44, -14.93 -54.7, -32.97 APE12-dist-na 12.7562 APE11-dist-na 9.3201 APE10-dist-na 6.0089 APE9-dist-in 7.4173 E1097A,E1099A None None XRAY 2.2 0.195 0.218 E 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNF P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.6688 11.6863 None -119.91, -143.87 -36.57, 117.22 -111.83, 7.84 53.92, 93.37 -86.48, -19.66 out-out out 10.2445 Saltbr-out 7.4948 HRD-in -71.54, -45.74 77.92, -19.28 out-out-in SNCooi out-in ActLoopNT-out 8.9724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.77, 125.58 APE9-dihe-in -123.67, 120.15 APE8-dihe-in -81.16, 71.31 APE8-rot-na 31.34 APE67-dihe-in -70.78, -14.02 -54.99, -34.82 APE12-dist-na 12.6961 APE11-dist-na 9.4311 APE10-dist-na 6.0247 APE9-dist-in 7.4146 E1097A,E1099A None None XRAY 2.2 0.195 0.218 F 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNG P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.4952 11.8883 None -115.22, -143.92 -37.17, 121.14 -119.03, 5.44 57.57, 87.05 -84.31, -13.87 out-out out 10.2119 Saltbr-out 6.5677 HRD-in -69.56, -54.08 84.44, -12.44 out-out-in SNCooi out-in ActLoopNT-out 8.9987 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.44, 128.11 APE9-dihe-in -122.01, 115.9 APE8-dihe-in -78.8, 69.19 APE8-rot-na 29.58 APE67-dihe-in -71.28, -16.87 -55.78, -34.47 APE12-dist-na 13.0183 APE11-dist-na 9.4183 APE10-dist-na 6.0678 APE9-dist-in 7.3121 E1097A,E1099A None None XRAY 2.2 0.195 0.218 G 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNH P08069 983 1285 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5638 11.8399 None -117.51, -139.77 -40.96, 115.52 -113.35, 4.84 52.59, 91.03 -79.05, -20.18 out-out out 10.169 Saltbr-out 7.1318 HRD-in -75.23, -47.04 79.69, -19.55 out-out-in SNCooi out-in ActLoopNT-out 9.1132 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.78, 128.57 APE9-dihe-in -119.04, 118.91 APE8-dihe-in -80.75, 73.24 APE8-rot-na 32.94 APE67-dihe-in -74.0, -12.28 -56.22, -33.69 APE12-dist-na 13.1839 APE11-dist-na 9.2607 APE10-dist-na 6.0308 APE9-dist-in 7.4487 E1097A,E1099A None None XRAY 2.2 0.195 0.218 H 304.0 303.0 0 30 30 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.6413 13.7197 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.8952 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6829 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306.0 282.0 16 30 14 16 [[1023, 1292]] 1.0 1i44 TYR_INSR_HUMAN TYR 3.4e-96 327.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 1P14A P06213 1005 1310 1382.0 No_ligand No_ligand Inactive DFGin 7.6107 15.3442 None -93.61, -127.04 -78.93, 153.19 -166.81, 155.93 65.2, 94.97 -69.26, 999.0 in-out in 9.2508 Saltbr-out 5.4695 HRD-in -68.39, -55.7 74.95, -11.95 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.41 APE8-rot-na 37.98 APE67-dihe-in -68.35, -7.74 -43.78, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1008S,D1159N None None XRAY 1.9 0.225 0.24 A 306.0 287.0 19 30 11 19 [[1023, 1292]] 1.0 1p14 TYR_INSR_HUMAN TYR 5e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 4IBMA P06213 1009 1309 1382.0 IR1:61301 Type1 Inactive DFGin 5.6235 15.3135 None -76.0, 163.85 -44.82, 128.63 -69.67, 135.99 297.32, 165.57 60.17, 44.87 out-out out 10.6453 Saltbr-out 7.271 HRD-in -68.74, -46.51 75.22, -15.25 out-out-in SNCooi out-in ActLoopNT-out 15.6653 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 121.44 APE9-dihe-in -109.91, 120.82 APE8-dihe-in -81.27, 70.1 APE8-rot-na 28.73 APE67-dihe-in -71.57, -11.47 -57.01, -32.73 APE12-dist-na 18.7378 APE11-dist-na 15.2744 APE10-dist-na 11.5056 APE9-dist-in 7.3145 K1278N None None XRAY 1.8 0.184 0.218 A 306.0 301.0 0 30 30 0 [[1023, 1292]] 1.0 4ibm TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 4IBMB P06213 1014 1310 1382.0 IR1:61301 Type1 Inactive DFGin 6.943 16.4452 None -69.6, 155.55 -45.67, 125.47 -61.25, 129.45 282.72, 8.49 78.34, 8.83 in-out in 9.4175 Saltbr-out 5.034 HRD-in -66.87, -50.14 74.82, -11.33 out-out-in SNCooi out-in ActLoopNT-out 15.2219 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.04, 122.58 APE9-dihe-in -120.44, 134.35 APE8-dihe-in -81.79, 69.08 APE8-rot-na 32.76 APE67-dihe-in -70.68, -10.48 -58.86, -32.74 APE12-dist-na 19.958 APE11-dist-na 16.3087 APE10-dist-na 12.6646 APE9-dist-in 7.3059 K1278N None None XRAY 1.8 0.184 0.218 B 306.0 294.0 3 30 30 0 [[1023, 1292]] 1.0 4ibm TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 5E1SA P06213 1010 1310 1382.0 5JA:61301 Type1 Inactive DFGin 6.8652 15.0896 None -82.55, -126.51 -82.76, 146.74 -146.5, 173.12 61.91, 96.0 -67.13, 97.4 in-out in 8.8331 Saltbr-out 6.372 HRD-in -66.03, -52.34 70.18, -7.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -78.62, 65.27 APE8-rot-na 31.33 APE67-dihe-in -70.73, -11.27 -48.96, -36.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3247 None None None XRAY 2.264 0.215 0.262 A 308.0 284.0 17 30 13 17 [[1023, 1292]] 1.0 5e1s TYR_INSR_HUMAN TYR 5.6e-96 326.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 3EKKA P06213 1007 1309 1382.0 GS2:60001 Type1 Inactive DFGin 6.9318 15.2617 None -91.44, -126.11 -77.81, 134.04 -139.23, 999.0 58.35, 102.32 999.0, 999.0 in-out in 9.2869 Saltbr-out 5.3303 HRD-in -69.72, -54.17 78.3, -13.96 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -25.52 APE9-dihe-in -83.53, 136.03 APE8-dihe-in -85.94, 70.21 APE8-rot-na 27.34 APE67-dihe-in -74.98, -12.32 -58.97, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5248 C1008S,D1159N None None XRAY 2.1 0.207 0.26 A 307.0 285.0 18 30 12 18 [[1023, 1292]] 1.0 3ekk TYR_INSR_HUMAN TYR 5.1e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 3EKNA P06213 1011 1310 1382.0 GS3:60001 Type1 Inactive DFGin 6.2472 13.3535 None -59.53, -41.76 -156.68, -173.98 -81.39, 6.66 55.61, 95.58 69.22, 37.13 in-out in 8.4857 Saltbr-out 4.158 HRD-in -69.98, -55.95 75.05, -7.0 out-out-out SNCooo out-out ActLoopNT-out 9.4799 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.36, -23.41 APE9-dihe-in -94.03, 128.42 APE8-dihe-in -84.32, 117.17 APE8-rot-na 4.91 APE67-dihe-in -79.33, -4.28 -67.04, -22.99 APE12-dist-na 999.0 APE11-dist-na 13.7116 APE10-dist-na 9.2366 APE9-dist-in 4.8268 C1008S,D1159N None None XRAY 2.2 0.214 0.274 A 307.0 297.0 3 30 27 3 [[1023, 1292]] 1.0 3ekn TYR_INSR_HUMAN TYR 5.1e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 5HHWA P06213 1005 1310 1382.0 60O:1401 Type1.5_Front Inactive DFGin 6.5467 15.218 None -93.96, -126.86 -75.33, 119.05 -115.08, 17.9 55.03, 94.29 -68.54, 168.98 in-out in 9.6442 Saltbr-out 6.2026 HRD-in -63.14, -55.1 75.15, -13.24 out-out-in SNCooi out-in ActLoopNT-out 12.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.8, 124.07 APE9-dihe-in -122.61, 132.0 APE8-dihe-in -80.76, 65.66 APE8-rot-na 27.91 APE67-dihe-in -68.74, -10.86 -50.91, -39.07 APE12-dist-na 13.7099 APE11-dist-na 10.9449 APE10-dist-na 9.756 APE9-dist-in 7.5063 C1008S,D1159N None None XRAY 1.79 0.172 0.198 A 307.0 306.0 0 30 30 0 [[1023, 1292]] 1.0 5hhw TYR_INSR_HUMAN TYR 5.5e-96 326.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR ITK ITK_HUMAN 3MIYA Q08881 357 619 620.0 B49:60001 Type1 Inactive DFGin 4.4986 14.3272 None -118.72, 169.24 51.5, 47.57 -103.74, 999.0 53.54, 86.2 999.0, 999.0 in-out in 9.8276 Saltbr-out 5.0446 HRD-in -71.62, -53.3 80.88, -14.93 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.04 APE8-rot-na 334.29 APE67-dihe-in -65.24, -21.92 -59.14, -28.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C477S,E614A,E617A None None XRAY 1.67 0.208 0.234 A 266.0 237.0 26 29 10 19 [[363, 614]] 1.0 3miy TYR_ITK_HUMAN TYR 5e-93 317.1 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3MJ1A Q08881 357 615 620.0 614:60001 Type1 Inactive DFGin 5.9676 13.3428 None -126.6, 166.8 59.09, 29.18 -76.15, 999.0 48.51, 86.56 999.0, 999.0 out-out out 13.5229 Saltbr-out 12.0653 HRD-in -66.18, -54.69 85.37, -19.01 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.56 APE8-rot-na 26.94 APE67-dihe-in -66.28, -13.64 -60.47, -30.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C477S,E614A,E617A None None XRAY 1.72 0.238 0.264 A 266.0 226.0 33 29 10 19 [[363, 614]] 1.0 3mj1 TYR_ITK_HUMAN TYR 5e-93 317.1 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PQNA Q08881 357 615 620.0 2W6:701 Type1 Inactive DFGin 5.2901 14.7453 None -102.53, 173.37 -57.89, 164.97 -164.74, 161.08 47.42, 91.82 137.98, 999.0 in-out in 9.105 Saltbr-out 4.4161 HRD-in -70.76, -53.31 78.34, -16.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.94 APE8-dihe-in -78.94, 66.59 APE8-rot-na 37.6 APE67-dihe-in -61.43, -23.35 -57.61, -35.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.9577 C477S,E614A,E617A None None XRAY 1.71 0.161 0.202 A 266.0 240.0 19 29 12 17 [[363, 614]] 1.0 4pqn TYR_ITK_HUMAN TYR 5e-93 317.1 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4MF0B Q08881 357 619 620.0 29Z:701 Type1 Inactive DFGin 6.8221 14.6295 None -147.79, -179.99 59.06, 76.1 -152.71, 999.0 51.7, 89.28 999.0, 999.0 out-out out 13.6042 Saltbr-out 14.5985 HRD-in -57.08, -45.93 79.95, -24.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.72 APE8-rot-na 30.57 APE67-dihe-in -60.16, -25.12 -59.46, -35.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y512E None None XRAY 2.67 0.215 0.268 B 266.0 237.0 26 29 10 19 [[363, 614]] 1.0 4mf0 TYR_ITK_HUMAN TYR 2.1e-92 315.0 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PPCA Q08881 357 619 620.0 2VW:60701 Type1 Inactive DFGin 7.2293 13.3321 None -135.89, 168.01 69.21, 69.58 -147.47, 999.0 49.13, 86.55 999.0, 999.0 out-out out 13.4252 Saltbr-out 11.899 HRD-in -71.06, -46.31 73.14, -9.54 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.1 APE8-rot-na 25.52 APE67-dihe-in -66.61, -24.14 -69.06, -21.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y512E None None XRAY 2.95 0.215 0.257 A 266.0 232.0 31 29 10 19 [[363, 614]] 1.0 4ppc TYR_ITK_HUMAN TYR 2.1e-92 315.0 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PPCB Q08881 357 619 620.0 2VW:60701 Type1 Inactive DFGin 6.5864 13.7199 None -127.88, 164.09 63.12, 56.47 -117.01, 999.0 50.83, 90.79 999.0, 999.0 out-out out 13.4584 Saltbr-out 10.2014 HRD-in -62.38, -51.21 79.16, -15.21 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.83 APE8-rot-na 22.06 APE67-dihe-in -58.68, -39.7 -66.95, -19.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y512E None None XRAY 2.95 0.215 0.257 B 266.0 230.0 33 29 10 19 [[363, 614]] 1.0 4ppc TYR_ITK_HUMAN TYR 2.1e-92 315.0 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3QGWB Q08881 358 616 620.0 L7A:1 Type1 Inactive DFGin 5.1023 13.9528 None -132.64, -179.26 57.93, 42.12 -120.25, 999.0 60.69, 93.21 999.0, 999.0 in-out in 9.0896 Saltbr-out 5.424 HRD-in -75.97, -46.45 75.23, -6.09 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.51 APE8-rot-na 37.77 APE67-dihe-in -72.69, -9.67 -54.86, -23.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.245 0.32 B 286.0 240.0 19 29 10 19 [[363, 614]] 1.0 3qgw TYR_ITK_HUMAN TYR 1.3e-92 315.7 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SM2B Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.378 13.3785 None -126.46, -161.15 38.96, 42.72 -115.58, 999.0 63.86, 78.79 999.0, 999.0 out-out out 11.099 Saltbr-out 6.8051 HRD-out -89.1, 89.71 -64.14, 17.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.78 APE8-rot-na 24.5 APE67-dihe-in -53.23, -18.63 -53.68, -42.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 B 264.0 241.0 19 29 10 19 [[363, 614]] 1.0 1sm2 TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUB Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.3215 13.3612 None -135.24, -161.39 47.41, 33.44 -112.08, 999.0 66.07, 77.87 999.0, 999.0 out-out out 11.1179 Saltbr-out 7.4836 HRD-out -85.26, 96.7 -69.16, 21.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.67 APE8-rot-na 31.48 APE67-dihe-in -68.53, -31.16 -49.5, -27.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 B 264.0 241.0 19 29 10 19 [[363, 614]] 1.0 1snu TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3V5JB Q08881 357 620 620.0 0F2:60701 Type1 Inactive DFGin 4.4328 14.4384 None -124.07, 161.2 59.09, 58.27 -105.58, 999.0 45.39, 90.64 999.0, 999.0 out-none out 10.3469 Saltbr-none 999.0 HRD-out -89.74, 97.95 -71.99, -8.9 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 8.88 APE8-rot-na 21.22 APE67-dihe-in -67.81, -24.63 -68.6, -25.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.246 0.27 B 266.0 239.0 25 29 10 19 [[363, 614]] 1.0 3v5j TYR_ITK_HUMAN TYR 9.4e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR JAK1-1 JAK1_HUMAN 4L01A P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.7918 12.0795 None -73.75, -179.09 -73.9, 162.14 -73.89, -15.61 344.71, 28.42 67.96, -153.13 in-na in 9.5433 Saltbr-na 999.0 HRD-in -87.9, -71.89 94.16, -0.24 na-out-out SNCaoo out-out ActLoopNT-out 7.9539 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.86, -39.57 APE9-dihe-out -58.05, -29.58 APE8-dihe-out -81.67, -7.08 APE8-rot-na 199.85 APE67-dihe-out -101.51, 19.28 -61.73, 134.72 APE12-dist-na 9.3413 APE11-dist-na 11.7555 APE10-dist-na 15.957 APE9-dist-out 11.1256 V658F None None XRAY 1.9 0.204 0.233 A 304.0 274.0 12 24 24 0 [[583, 847], [875, 1151]] 2.0 4l01 TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L01B P23458 565 849 1154.0 No_ligand No_ligand Pseudo DFGin 6.8232 11.8723 None -76.74, -176.42 -72.49, 166.45 -77.53, -11.38 359.0, 15.1 69.24, -153.25 in-na in 8.8926 Saltbr-na 999.0 HRD-in -86.59, -73.54 93.9, -0.47 na-out-out SNCaoo out-out ActLoopNT-out 8.016 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.69, -39.64 APE9-dihe-out -57.55, -28.87 APE8-dihe-out -85.94, -3.15 APE8-rot-na 200.27 APE67-dihe-out -99.61, 21.88 -63.69, 136.29 APE12-dist-na 9.2987 APE11-dist-na 11.6951 APE10-dist-na 15.8459 APE9-dist-out 11.03 V658F None None XRAY 1.9 0.204 0.233 B 304.0 274.0 11 24 24 0 [[583, 847], [875, 1151]] 2.0 4l01 TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00A P23458 564 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.9117 11.988 None -76.07, -177.45 -75.3, 165.45 -78.74, -7.85 349.06, 24.36 63.89, -153.3 in-na in 9.5606 Saltbr-na 999.0 HRD-in -93.36, -71.42 93.51, 0.78 na-out-out SNCaoo out-out ActLoopNT-out 7.9607 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.21, -40.39 APE9-dihe-out -55.79, -30.01 APE8-dihe-out -85.56, 0.43 APE8-rot-na 187.12 APE67-dihe-out -101.03, 20.07 -69.52, 138.76 APE12-dist-na 9.4963 APE11-dist-na 11.8801 APE10-dist-na 16.1265 APE9-dist-out 11.1634 None None None XRAY 1.8 0.171 0.203 A 304.0 277.0 10 24 24 0 [[583, 847], [875, 1151]] 2.0 4l00 TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00B P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.8723 11.9738 None -78.39, -173.09 -77.68, 164.49 -74.46, -8.56 347.77, 22.41 63.58, -153.63 in-na in 8.9735 Saltbr-na 999.0 HRD-in -90.15, -72.75 94.75, 3.66 na-out-out SNCaoo out-out ActLoopNT-out 7.929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.66, -39.95 APE9-dihe-out -56.84, -31.4 APE8-dihe-out -81.07, -3.08 APE8-rot-na 200.04 APE67-dihe-out -104.62, 20.8 -63.46, 134.32 APE12-dist-na 9.3701 APE11-dist-na 11.8496 APE10-dist-na 15.9108 APE9-dist-out 11.081 None None None XRAY 1.8 0.171 0.203 B 304.0 278.0 8 24 24 0 [[583, 847], [875, 1151]] 2.0 4l00 TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.6682 13.3858 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.6814 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.0371 APE11-dist-na 11.7 APE10-dist-na 16.2781 APE9-dist-out 12.3723 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5i4n TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.7656 13.3758 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.7821 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.5367 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.4734 APE10-dist-na 16.0369 APE9-dist-out 12.0279 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvr TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.4109 13.5312 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.3574 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.0941 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.9123 APE11-dist-na 11.4873 APE10-dist-na 16.0746 APE9-dist-out 12.3782 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvq TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.5983 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.3998 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.4736 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.9203 APE11-dist-na 11.8594 APE10-dist-na 16.3524 APE9-dist-out 12.5304 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289.0 270.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.6459 13.5394 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.1784 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.7296 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.8478 APE11-dist-na 11.8372 APE10-dist-na 16.5999 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289.0 269.0 6 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4B O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.0162 13.6285 None -84.33, -175.92 -78.92, 160.47 -67.97, -29.51 344.52, 29.43 84.02, -159.01 out-na out 10.5477 Saltbr-na 999.0 HRD-in -80.56, -60.88 93.85, -0.35 na-out-out SNCaoo out-out ActLoopNT-out 9.2529 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.77, -41.18 APE9-dihe-out -60.58, -30.76 APE8-dihe-out -85.29, 2.29 APE8-rot-na 288.75 APE67-dihe-out -100.46, 22.84 -59.03, 138.57 APE12-dist-na 9.6698 APE11-dist-na 11.3976 APE10-dist-na 15.9347 APE9-dist-out 12.6673 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 B 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba4 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVPA O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.8931 13.0904 None -91.01, 179.45 -75.79, 153.56 -78.3, -11.29 26.93, 143.21 73.75, -158.65 out-na out 13.1657 Saltbr-na 999.0 HRD-in -83.21, -62.84 93.75, -4.6 na-out-out SNCaoo out-out ActLoopNT-out 9.629 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.0, -41.33 APE9-dihe-out -58.79, -30.31 APE8-dihe-out -86.85, 3.46 APE8-rot-na 297.22 APE67-dihe-out -102.61, 25.98 -63.62, 134.65 APE12-dist-na 9.8827 APE11-dist-na 11.6748 APE10-dist-na 16.1441 APE9-dist-out 12.5432 W659A,W777A,F794H None None XRAY 2.01 0.181 0.212 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvp TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C09A O60674 538 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.0525 13.2527 None -86.22, -176.26 -73.29, 161.33 -72.41, -30.09 344.35, 29.81 80.16, -162.74 out-na out 11.184 Saltbr-na 999.0 HRD-in -80.44, -66.09 97.2, -4.64 na-out-out SNCaoo out-out ActLoopNT-out 9.0791 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.51, -34.73 APE9-dihe-out -64.77, -31.42 APE8-dihe-out -84.71, 1.64 APE8-rot-na 292.35 APE67-dihe-out -99.58, 28.31 -60.08, 137.86 APE12-dist-na 9.8638 APE11-dist-na 11.5573 APE10-dist-na 16.1216 APE9-dist-out 12.4835 I559F,W659A,W777A,F794H None None XRAY 1.9 0.223 0.257 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c09 TYR_JAK2-1_HUMAN TYR 1.3e-63 220.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CA O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.9293 13.2972 None -92.88, -174.23 -74.55, 160.0 -77.81, -9.76 27.51, 143.79 70.13, -167.0 in-na in 9.4623 Saltbr-na 999.0 HRD-in -89.47, -61.45 91.27, -4.79 na-out-out SNCaoo out-out ActLoopNT-out 9.753 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.76, -39.79 APE9-dihe-out -61.91, -29.13 APE8-dihe-out -80.12, 0.2 APE8-rot-na 289.19 APE67-dihe-out -101.75, 22.48 -69.62, 136.72 APE12-dist-na 9.7666 APE11-dist-na 11.5665 APE10-dist-na 16.1545 APE9-dist-out 12.7021 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 A 272.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6g3c TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CB O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.9902 13.415 None -91.77, -175.11 -73.45, 159.45 -76.52, -11.86 28.49, 143.52 73.41, -164.04 in-na in 9.643 Saltbr-na 999.0 HRD-in -89.94, -61.82 90.1, -3.95 na-out-out SNCaoo out-out ActLoopNT-out 9.6929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.88, -39.41 APE9-dihe-out -62.88, -28.18 APE8-dihe-out -81.21, 1.24 APE8-rot-na 288.18 APE67-dihe-out -102.69, 23.29 -70.43, 136.03 APE12-dist-na 9.7694 APE11-dist-na 11.5802 APE10-dist-na 16.1381 APE9-dist-out 12.6902 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 B 272.0 268.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6g3c TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IA O60674 536 808 1132.0 35R:901 Type1 Pseudo DFGin 6.5522 13.6514 None -85.6, -168.64 -71.02, 159.25 -67.8, -19.61 341.93, 32.5 72.61, -145.53 in-na in 9.6393 Saltbr-na 999.0 HRD-in -88.15, -70.56 100.36, -8.76 na-out-out SNCaoo out-out ActLoopNT-out 9.7002 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.19, -30.63 APE9-dihe-out -73.76, -13.56 APE8-dihe-out -89.52, 2.58 APE8-rot-na 300.29 APE67-dihe-out -99.98, 28.53 -66.76, 135.82 APE12-dist-na 10.5196 APE11-dist-na 11.5137 APE10-dist-na 16.3152 APE9-dist-out 13.0189 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 A 273.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IB O60674 537 808 1132.0 35R:901 Type1 Pseudo DFGin 6.7449 13.508 None -83.97, -172.62 -69.78, 158.02 -65.46, -20.62 341.26, 32.34 71.79, -145.54 in-na in 9.4363 Saltbr-na 999.0 HRD-in -84.58, -69.97 97.0, -6.55 na-out-out SNCaoo out-out ActLoopNT-out 9.4489 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.97, -30.79 APE9-dihe-out -72.59, -17.09 APE8-dihe-out -89.77, 2.61 APE8-rot-na 301.92 APE67-dihe-out -99.31, 27.86 -67.19, 135.78 APE12-dist-na 10.5863 APE11-dist-na 11.8904 APE10-dist-na 16.6501 APE9-dist-out 12.8955 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 B 273.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8NA O60674 536 809 1132.0 AQG:904 Type1 Pseudo DFGin 6.9922 13.5588 None -86.6, 176.83 -72.07, 163.0 -83.55, -11.71 8.83, 7.64 73.11, -166.45 out-na out 10.2232 Saltbr-na 999.0 HRD-in -77.47, -60.54 92.78, -1.1 na-out-out SNCaoo out-out ActLoopNT-out 9.2549 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.27, -38.06 APE9-dihe-out -61.66, -30.26 APE8-dihe-out -80.2, 3.05 APE8-rot-na 289.81 APE67-dihe-out -99.17, 33.25 -63.6, 138.44 APE12-dist-na 9.5537 APE11-dist-na 11.4484 APE10-dist-na 15.9705 APE9-dist-out 12.4531 W659A,W777A,F794H None None XRAY 2.0 0.211 0.255 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8n TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.821 13.2982 None -86.5, 168.2 -72.83, 159.81 -77.39, -5.69 29.32, 142.66 68.85, -165.5 in-na in 9.6368 Saltbr-na 999.0 HRD-in -85.53, -63.36 91.05, -0.77 na-out-out SNCaoo out-out ActLoopNT-out 9.5857 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -40.18 APE9-dihe-out -60.78, -27.05 APE8-dihe-out -85.5, 2.2 APE8-rot-na 288.85 APE67-dihe-out -105.88, 26.49 -64.53, 136.9 APE12-dist-na 9.8393 APE11-dist-na 11.5435 APE10-dist-na 16.1353 APE9-dist-out 12.651 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8u TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UB O60674 538 809 1132.0 T7I:903 Type1 Pseudo DFGin 7.6842 13.3671 None -85.95, 172.23 -73.23, 159.57 -79.19, -7.74 28.18, 144.77 71.86, -165.96 in-na in 9.8706 Saltbr-na 999.0 HRD-in -85.44, -62.47 91.56, -1.37 na-out-out SNCaoo out-out ActLoopNT-out 9.4049 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.42, -39.8 APE9-dihe-out -61.59, -26.48 APE8-dihe-out -85.69, -0.76 APE8-rot-na 289.8 APE67-dihe-out -104.95, 23.87 -61.36, 134.02 APE12-dist-na 9.8928 APE11-dist-na 11.4874 APE10-dist-na 16.1064 APE9-dist-out 12.5476 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 B 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8u TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA2A O60674 536 810 1132.0 Q9X:907 Type1 Pseudo DFGin 5.7073 13.2724 None -74.82, 174.75 -67.11, 161.11 -77.71, -21.19 340.67, 34.41 73.6, -166.64 out-na out 11.6572 Saltbr-na 999.0 HRD-in -83.09, -59.59 87.04, -0.99 na-out-out SNCaoo out-out ActLoopNT-out 8.9491 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.59, -40.16 APE9-dihe-out -57.17, -31.99 APE8-dihe-out -85.57, 4.75 APE8-rot-na 288.77 APE67-dihe-out -102.79, 29.41 -64.21, 136.1 APE12-dist-na 9.7351 APE11-dist-na 11.4317 APE10-dist-na 16.0182 APE9-dist-out 12.2832 W659A,W777A,F794H None None XRAY 1.5 0.178 0.204 A 289.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba2 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4A O60674 536 809 1132.0 Q8U:901 Type1 Pseudo DFGin 7.9438 13.4117 None -71.69, 172.79 -67.86, 161.07 -79.48, -19.97 29.54, 146.52 81.3, -166.68 in-na in 9.7879 Saltbr-na 999.0 HRD-in -74.34, -63.4 91.62, 2.89 na-out-out SNCaoo out-out ActLoopNT-out 8.5896 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.98, -39.28 APE9-dihe-out -56.91, -30.54 APE8-dihe-out -86.08, -1.03 APE8-rot-na 290.49 APE67-dihe-out -99.32, 21.83 -60.56, 137.6 APE12-dist-na 9.9255 APE11-dist-na 11.6473 APE10-dist-na 16.1443 APE9-dist-out 12.3271 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba4 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WA O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.915 13.7962 None -91.54, 171.73 -67.57, 155.24 -69.34, -22.33 351.29, 21.05 78.83, -168.1 out-na out 10.1693 Saltbr-na 999.0 HRD-in -84.02, -62.23 90.48, 0.05 na-out-out SNCaoo out-out ActLoopNT-out 9.7232 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.04, -35.76 APE9-dihe-out -66.77, -25.16 APE8-dihe-out -85.21, 3.67 APE8-rot-na 284.34 APE67-dihe-out -100.56, 25.85 -66.38, 135.35 APE12-dist-na 9.6893 APE11-dist-na 11.4731 APE10-dist-na 16.0322 APE9-dist-out 12.6531 None None None XRAY 1.83 0.208 0.238 A 275.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7f7w TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WB O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.9033 13.6869 None -84.95, 175.07 -74.42, 156.63 -70.62, -23.21 351.87, 21.25 77.0, -167.15 out-na out 10.2517 Saltbr-na 999.0 HRD-in -79.03, -66.0 95.6, -1.12 na-out-out SNCaoo out-out ActLoopNT-out 9.4951 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.33, -37.68 APE9-dihe-out -69.53, -21.97 APE8-dihe-out -87.12, 4.19 APE8-rot-na 285.11 APE67-dihe-out -99.09, 24.95 -67.63, 136.04 APE12-dist-na 9.7044 APE11-dist-na 11.4907 APE10-dist-na 16.0173 APE9-dist-out 12.671 None None None XRAY 1.83 0.208 0.238 B 275.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7f7w TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B99A O60674 536 809 1132.0 SKE:1003 Type1 Pseudo DFGin 5.8292 13.1897 None -69.78, 174.05 -70.57, 162.32 -72.88, -28.63 342.75, 30.69 79.14, -167.36 out-na out 11.6139 Saltbr-na 999.0 HRD-in -83.46, -62.07 90.64, -3.52 na-out-out SNCaoo out-out ActLoopNT-out 8.8443 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.87, -40.42 APE9-dihe-out -54.81, -33.54 APE8-dihe-out -85.07, 3.29 APE8-rot-na 283.44 APE67-dihe-out -103.17, 28.18 -66.12, 134.93 APE12-dist-na 9.7642 APE11-dist-na 11.3667 APE10-dist-na 15.959 APE9-dist-out 12.1602 W777A,F794H None None XRAY 1.6 0.19 0.211 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b99 TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.7694 13.2256 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.7256 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.9495 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.6132 APE11-dist-na 11.3156 APE10-dist-na 15.8543 APE9-dist-out 12.1058 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9e TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BABA O60674 536 809 1132.0 Q8N:908 Type1 Pseudo DFGin 5.7827 13.347 None -82.44, 178.74 -69.43, 159.24 -76.71, -21.64 341.13, 33.08 75.74, -169.92 out-na out 11.796 Saltbr-na 999.0 HRD-in -85.23, -57.58 89.38, -3.23 na-out-out SNCaoo out-out ActLoopNT-out 9.0793 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.14, -39.62 APE9-dihe-out -58.1, -35.37 APE8-dihe-out -80.74, 3.58 APE8-rot-na 288.39 APE67-dihe-out -100.89, 27.42 -62.52, 138.56 APE12-dist-na 9.8808 APE11-dist-na 11.4994 APE10-dist-na 16.1225 APE9-dist-out 12.5374 W777A,F794H None None XRAY 1.55 0.176 0.203 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8bab TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BAKA O60674 536 809 1132.0 AD5:906 Type1 Pseudo DFGin 5.9 13.4848 None -79.74, 176.09 -70.26, 155.83 -67.8, -33.14 338.52, 35.12 82.51, -172.71 out-na out 11.7434 Saltbr-na 999.0 HRD-in -82.49, -60.1 89.16, -0.66 na-out-out SNCaoo out-out ActLoopNT-out 9.0218 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.79, -43.24 APE9-dihe-out -56.17, -32.1 APE8-dihe-out -84.4, 4.03 APE8-rot-na 284.51 APE67-dihe-out -100.67, 27.47 -64.95, 137.17 APE12-dist-na 9.8834 APE11-dist-na 11.5875 APE10-dist-na 16.1406 APE9-dist-out 12.6164 W777A,F794H None None XRAY 1.65 0.185 0.207 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8bak TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.565 13.3537 None -83.75, 166.81 -71.24, 158.41 -74.12, -10.51 25.45, 142.36 78.43, -168.66 in-na in 9.5594 Saltbr-na 999.0 HRD-in -83.22, -65.0 92.23, 1.81 na-out-out SNCaoo out-out ActLoopNT-out 9.6006 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -71.23, -34.89 APE9-dihe-out -65.21, -28.5 APE8-dihe-out -84.82, 8.34 APE8-rot-na 293.37 APE67-dihe-out -106.96, 23.1 -69.15, 131.91 APE12-dist-na 9.8924 APE11-dist-na 11.6237 APE10-dist-na 16.1468 APE9-dist-out 12.5708 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c0a TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AB O60674 536 808 1132.0 T7I:902 Type1 Pseudo DFGin 7.4852 13.3983 None -84.77, 172.51 -72.53, 156.76 -75.35, -8.78 26.64, 140.87 71.28, -164.53 in-na in 9.8045 Saltbr-na 999.0 HRD-in -81.32, -65.94 88.05, 6.45 na-out-out SNCaoo out-out ActLoopNT-out 9.4136 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.73, -37.68 APE9-dihe-out -64.41, -27.87 APE8-dihe-out -85.03, 1.77 APE8-rot-na 284.08 APE67-dihe-out -105.43, 24.1 -65.54, 134.17 APE12-dist-na 9.7722 APE11-dist-na 11.4589 APE10-dist-na 16.0887 APE9-dist-out 12.4962 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 B 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c0a TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIJA O60674 536 809 1132.0 AQG:901 Type1 Pseudo DFGin 7.8557 13.5657 None -91.12, 177.94 -71.51, 155.95 -79.01, -8.25 29.98, 143.91 73.76, -166.11 in-na in 9.9173 Saltbr-na 999.0 HRD-in -72.47, -68.91 101.27, -5.66 na-out-out SNCaoo out-out ActLoopNT-out 9.3062 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.59, -26.98 APE9-dihe-out -64.74, -27.71 APE8-dihe-out -87.29, 3.84 APE8-rot-na 291.39 APE67-dihe-out -100.01, 30.88 -65.27, 134.93 APE12-dist-na 9.6175 APE11-dist-na 11.4946 APE10-dist-na 15.9937 APE9-dist-out 12.5098 W659A,W777A,F794H None None XRAY 2.04 0.209 0.231 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wij TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIKB O60674 536 809 1132.0 584:901 Type1 Pseudo DFGin 8.1996 13.4773 None -86.83, -177.1 -74.98, 154.5 -75.92, -8.34 30.63, 142.46 77.38, -163.2 out-na out 10.0153 Saltbr-na 999.0 HRD-in -75.13, -71.22 102.4, -1.09 na-out-out SNCaoo out-out ActLoopNT-out 9.4124 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.94, -26.86 APE9-dihe-out -70.71, -25.41 APE8-dihe-out -85.62, 4.24 APE8-rot-na 286.3 APE67-dihe-out -97.88, 28.27 -66.61, 137.0 APE12-dist-na 9.6629 APE11-dist-na 11.4185 APE10-dist-na 16.0555 APE9-dist-out 12.5943 W659A,W777A,F794H None None XRAY 2.6 0.211 0.251 B 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wik TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WILA O60674 536 809 1132.0 YDJ:901 Type1 Pseudo DFGin 7.5307 13.7171 None -83.87, 163.34 -72.42, 163.18 -87.02, -3.44 24.44, 145.33 75.07, -167.72 out-na out 10.4597 Saltbr-na 999.0 HRD-in -86.92, -55.39 94.23, -3.93 na-out-out SNCaoo out-out ActLoopNT-out 9.6652 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.97, -30.77 APE9-dihe-out -75.41, -19.35 APE8-dihe-out -84.61, 10.2 APE8-rot-na 287.01 APE67-dihe-out -99.8, 25.99 -70.86, 137.89 APE12-dist-na 9.547 APE11-dist-na 11.4807 APE10-dist-na 16.0397 APE9-dist-out 12.6921 W659A,W777A,F794H None None XRAY 2.2 0.201 0.231 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wil TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIMA O60674 536 809 1132.0 35R:901 Type1 Pseudo DFGin 7.7523 13.5845 None -93.28, 176.5 -38.24, 151.14 -78.63, -21.68 29.2, 149.11 81.15, -169.97 out-na out 10.5675 Saltbr-na 999.0 HRD-in -83.09, -66.39 96.8, 0.86 na-out-out SNCaoo out-out ActLoopNT-out 9.8496 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -105.18, -10.47 APE9-dihe-out -83.98, -20.52 APE8-dihe-out -80.31, 9.26 APE8-rot-na 299.8 APE67-dihe-out -97.29, 28.98 -67.31, 132.23 APE12-dist-na 9.8326 APE11-dist-na 11.5419 APE10-dist-na 15.898 APE9-dist-out 12.8889 W659A,W777A,F794H None None XRAY 2.55 0.211 0.258 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wim TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WINA O60674 536 809 1132.0 SKE:901 Type1 Pseudo DFGin 7.2805 13.7901 None -75.17, 174.41 -74.13, 155.6 -73.15, -17.87 26.75, 146.64 81.14, -159.91 out-na out 10.8153 Saltbr-na 999.0 HRD-in -80.84, -67.43 99.6, -2.16 na-out-out SNCaoo out-out ActLoopNT-out 9.5544 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -35.02 APE9-dihe-out -59.2, -25.51 APE8-dihe-out -88.93, -4.07 APE8-rot-na 287.0 APE67-dihe-out -96.98, 26.41 -56.71, 138.03 APE12-dist-na 9.5649 APE11-dist-na 11.6365 APE10-dist-na 16.0252 APE9-dist-out 12.3691 W659A,W777A,F794H None None XRAY 2.38 0.221 0.244 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5win TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5USZA O60674 537 808 1132.0 SKE:901 Type1 Pseudo DFGin 7.1469 13.1661 None -89.06, 179.4 -74.28, 155.49 -78.9, -12.42 30.8, 143.13 73.21, -171.41 in-na in 9.3491 Saltbr-na 999.0 HRD-in -84.39, -62.72 100.4, -8.06 na-out-out SNCaoo out-out ActLoopNT-out 9.8029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.11, -40.08 APE9-dihe-out -63.02, -23.47 APE8-dihe-out -87.07, 3.62 APE8-rot-na 290.38 APE67-dihe-out -103.08, 29.45 -63.02, 136.82 APE12-dist-na 10.1185 APE11-dist-na 11.6069 APE10-dist-na 16.2335 APE9-dist-out 12.8894 W659A,W777A,F794H None None XRAY 2.103 0.174 0.224 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5usz TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT0A O60674 537 808 1132.0 35R:903 Type1 Pseudo DFGin 7.594 13.5715 None -93.9, 174.39 -69.93, 155.11 -74.3, -13.06 28.06, 143.5 77.21, -173.63 in-na in 9.9387 Saltbr-na 999.0 HRD-in -83.57, -61.23 99.02, -12.98 na-out-out SNCaoo out-out ActLoopNT-out 9.9661 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.47, -40.74 APE9-dihe-out -59.34, -26.03 APE8-dihe-out -86.35, 4.34 APE8-rot-na 287.5 APE67-dihe-out -101.06, 28.12 -64.23, 136.97 APE12-dist-na 10.0051 APE11-dist-na 11.4779 APE10-dist-na 16.1348 APE9-dist-out 12.9322 W659A,W777A,F794H None None XRAY 2.102 0.171 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT1A O60674 537 808 1132.0 7DZ:905 Type1 Pseudo DFGin 7.3785 13.4637 None -94.09, -179.69 -75.66, 158.87 -74.76, -6.96 27.15, 144.11 69.28, -174.72 in-na in 9.6956 Saltbr-na 999.0 HRD-in -82.87, -62.64 95.48, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8118 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -38.46 APE9-dihe-out -62.2, -22.99 APE8-dihe-out -88.42, 4.71 APE8-rot-na 293.57 APE67-dihe-out -104.03, 27.01 -63.75, 135.14 APE12-dist-na 10.1099 APE11-dist-na 11.6437 APE10-dist-na 16.2104 APE9-dist-out 12.8829 W659A,W777A,F794H None None XRAY 1.95 0.165 0.202 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut1 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT2A O60674 536 808 1132.0 3YT:903 Type1 Pseudo DFGin 7.1266 13.3116 None -90.0, 179.18 -75.04, 157.7 -78.17, -8.03 29.61, 139.64 71.77, -178.13 in-na in 9.4878 Saltbr-na 999.0 HRD-in -87.63, -60.17 95.16, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.8702 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.9, -38.59 APE9-dihe-out -61.51, -24.95 APE8-dihe-out -88.74, 4.33 APE8-rot-na 288.64 APE67-dihe-out -101.61, 25.26 -63.02, 138.09 APE12-dist-na 10.0143 APE11-dist-na 11.5548 APE10-dist-na 16.1573 APE9-dist-out 12.8792 W659A,W777A,F794H None None XRAY 1.75 0.163 0.201 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut2 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT3A O60674 537 808 1132.0 IK1:901 Type1 Pseudo DFGin 7.2677 13.4017 None -92.6, 177.07 -71.65, 158.85 -79.65, -10.03 26.8, 143.01 73.38, -177.18 in-na in 9.6825 Saltbr-na 999.0 HRD-in -85.94, -61.54 97.51, -8.49 na-out-out SNCaoo out-out ActLoopNT-out 10.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.63, -39.44 APE9-dihe-out -66.05, -19.54 APE8-dihe-out -89.06, 2.9 APE8-rot-na 290.51 APE67-dihe-out -104.18, 27.32 -64.34, 136.22 APE12-dist-na 9.9898 APE11-dist-na 11.5779 APE10-dist-na 16.1923 APE9-dist-out 12.9958 W659A,W777A,F794H None None XRAY 1.501 0.156 0.17 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut3 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT4A O60674 537 809 1132.0 DQX:901 Type1 Pseudo DFGin 7.4596 13.2847 None -91.51, 174.25 -72.2, 155.17 -81.53, -6.98 30.25, 144.04 71.5, -173.67 in-na in 9.7389 Saltbr-na 999.0 HRD-in -82.44, -62.81 97.57, -6.96 na-out-out SNCaoo out-out ActLoopNT-out 9.5951 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.04, -37.57 APE9-dihe-out -62.17, -24.8 APE8-dihe-out -89.02, 2.73 APE8-rot-na 291.23 APE67-dihe-out -103.04, 31.05 -61.52, 137.36 APE12-dist-na 9.8738 APE11-dist-na 11.6283 APE10-dist-na 16.1461 APE9-dist-out 12.7464 W659A,W777A,F794H None None XRAY 2.0 0.18 0.22 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut4 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT5A O60674 537 808 1132.0 2HB:905 Type1 Pseudo DFGin 7.1887 13.2929 None -93.16, 174.58 -69.71, 153.91 -76.54, -10.06 29.7, 141.93 72.88, -178.86 in-na in 9.8227 Saltbr-na 999.0 HRD-in -86.78, -65.09 96.66, -4.13 na-out-out SNCaoo out-out ActLoopNT-out 9.8918 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.35, -36.77 APE9-dihe-out -64.06, -22.66 APE8-dihe-out -88.95, 4.87 APE8-rot-na 294.92 APE67-dihe-out -99.37, 27.39 -66.22, 138.89 APE12-dist-na 10.0661 APE11-dist-na 11.6537 APE10-dist-na 16.2639 APE9-dist-out 12.8254 W659A,W777A,F794H None None XRAY 1.9 0.162 0.201 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut5 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT6A O60674 537 808 1132.0 8MY:901 Type1 Pseudo DFGin 7.8108 13.3833 None -94.36, -179.3 -74.79, 159.2 -78.43, -9.68 26.67, 142.51 69.48, -170.15 in-na in 9.7616 Saltbr-na 999.0 HRD-in -88.85, -58.65 93.81, -8.0 na-out-out SNCaoo out-out ActLoopNT-out 9.8903 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.58, -38.89 APE9-dihe-out -63.87, -22.26 APE8-dihe-out -88.04, 3.04 APE8-rot-na 294.63 APE67-dihe-out -105.83, 26.71 -62.56, 137.4 APE12-dist-na 10.0473 APE11-dist-na 11.6725 APE10-dist-na 16.2366 APE9-dist-out 13.0236 W659A,W777A,F794H None None XRAY 1.645 0.169 0.206 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut6 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BRWA O60674 537 808 1132.0 5BS:901 Type1 Pseudo DFGin 7.7052 13.3794 None -93.41, 174.89 -67.04, 156.04 -83.01, 0.59 33.82, 139.96 67.03, -167.12 in-na in 9.6698 Saltbr-na 999.0 HRD-in -76.15, -62.39 95.18, -6.76 na-out-out SNCaoo out-out ActLoopNT-out 9.3464 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.9, -35.05 APE9-dihe-out -58.77, -25.82 APE8-dihe-out -90.17, 2.34 APE8-rot-na 284.96 APE67-dihe-out -99.82, 21.48 -62.86, 134.79 APE12-dist-na 9.9909 APE11-dist-na 11.5633 APE10-dist-na 16.1812 APE9-dist-out 12.8111 W659A,W777A,F794H None None XRAY 2.031 0.197 0.25 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6brw TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BS0A O60674 537 808 1132.0 E4V:901 Type1 Pseudo DFGin 7.0805 13.2557 None -88.58, 177.61 -73.17, 156.09 -79.5, -8.28 28.34, 142.63 71.71, -176.36 in-na in 9.568 Saltbr-na 999.0 HRD-in -86.4, -62.0 95.3, -5.83 na-out-out SNCaoo out-out ActLoopNT-out 9.9043 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.75, -38.73 APE9-dihe-out -60.18, -24.31 APE8-dihe-out -91.13, 4.36 APE8-rot-na 292.13 APE67-dihe-out -103.61, 24.99 -63.19, 136.77 APE12-dist-na 10.05 APE11-dist-na 11.6293 APE10-dist-na 16.2311 APE9-dist-out 12.9298 W659A,W777A,F794H None None XRAY 1.541 0.162 0.195 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6bs0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BSSA O60674 537 808 1132.0 4SP:902 Type1 Pseudo DFGin 7.5682 13.5106 None -92.12, 176.26 -71.33, 155.06 -76.95, -9.06 29.95, 143.27 73.96, -170.06 in-na in 9.6875 Saltbr-na 999.0 HRD-in -85.06, -63.73 98.07, -5.96 na-out-out SNCaoo out-out ActLoopNT-out 9.8876 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.01, -35.23 APE9-dihe-out -61.99, -26.69 APE8-dihe-out -86.73, 3.75 APE8-rot-na 289.32 APE67-dihe-out -100.38, 23.52 -64.28, 136.45 APE12-dist-na 9.9849 APE11-dist-na 11.5508 APE10-dist-na 16.1873 APE9-dist-out 12.8821 W659A,W777A,F794H None None XRAY 2.1 0.194 0.235 A 289.0 271.0 1 24 24 0 [[545, 807], [849, 1125]] 2.0 6bss TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6M9HA O60674 536 808 1132.0 J9D:901 Type1 Pseudo DFGin 7.8658 13.1991 None -93.81, -179.33 -75.36, 156.59 -79.44, -11.27 28.67, 140.35 75.69, -170.14 in-na in 9.7885 Saltbr-na 999.0 HRD-in -82.1, -57.99 92.46, -9.79 na-out-out SNCaoo out-out ActLoopNT-out 9.792 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.63, -41.5 APE9-dihe-out -66.06, -19.63 APE8-dihe-out -87.45, 2.93 APE8-rot-na 291.17 APE67-dihe-out -101.95, 25.55 -63.43, 136.79 APE12-dist-na 10.0491 APE11-dist-na 11.5902 APE10-dist-na 16.2066 APE9-dist-out 12.9593 W659A,W777A,F794H None None XRAY 1.79 0.172 0.206 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6m9h TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OAVA O60674 537 808 1132.0 M3A:901 Type1 Pseudo DFGin 7.1118 13.0392 None -89.82, 175.57 -71.85, 155.92 -76.93, -12.28 28.1, 145.13 74.45, -170.6 in-na in 9.8149 Saltbr-na 999.0 HRD-in -81.92, -60.26 97.52, -13.09 na-out-out SNCaoo out-out ActLoopNT-out 9.6491 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.27, -33.28 APE9-dihe-out -70.41, -15.65 APE8-dihe-out -94.12, 2.48 APE8-rot-na 295.49 APE67-dihe-out -103.53, 27.01 -62.67, 134.47 APE12-dist-na 9.9283 APE11-dist-na 11.4908 APE10-dist-na 16.0829 APE9-dist-out 12.7056 W659A,W777A,F794H None None XRAY 1.939 0.202 0.236 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6oav TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBBA O60674 537 808 1132.0 M3Y:901 Type1 Pseudo DFGin 7.3423 13.2339 None -84.34, 177.39 -74.24, 159.35 -79.81, -16.97 27.48, 144.61 78.13, -168.92 out-na out 10.1344 Saltbr-na 999.0 HRD-in -82.45, -60.11 93.59, -13.21 na-out-out SNCaoo out-out ActLoopNT-out 9.7343 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -38.37 APE9-dihe-out -67.29, -18.2 APE8-dihe-out -91.42, 5.55 APE8-rot-na 289.4 APE67-dihe-out -101.89, 28.31 -66.13, 136.22 APE12-dist-na 9.9763 APE11-dist-na 11.4381 APE10-dist-na 16.1001 APE9-dist-out 12.826 W659A,W777A,F794H None None XRAY 1.904 0.197 0.225 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obb TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBFA O60674 537 808 1132.0 M4G:902 Type1 Pseudo DFGin 5.8016 13.5747 None -75.4, 175.18 -69.61, 155.48 -61.14, -31.23 333.27, 38.74 78.42, -174.91 out-na out 11.7301 Saltbr-na 999.0 HRD-in -79.03, -58.03 90.73, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.1257 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.35, -37.95 APE9-dihe-out -66.08, -20.0 APE8-dihe-out -89.74, 3.4 APE8-rot-na 287.78 APE67-dihe-out -103.65, 28.29 -65.52, 135.12 APE12-dist-na 9.8761 APE11-dist-na 11.4144 APE10-dist-na 16.0183 APE9-dist-out 12.5198 W659A,W777A,F794H None None XRAY 1.71 0.199 0.222 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obf TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBLA O60674 537 808 1132.0 M4P:901 Type1 Pseudo DFGin 6.1314 13.618 None -84.06, 175.88 -72.71, 160.31 -68.63, -25.11 336.97, 36.63 73.61, -166.98 out-na out 11.5997 Saltbr-na 999.0 HRD-in -78.47, -60.55 94.84, -3.9 na-out-out SNCaoo out-out ActLoopNT-out 9.0751 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.59, -34.77 APE9-dihe-out -65.45, -25.46 APE8-dihe-out -86.12, 6.91 APE8-rot-na 289.77 APE67-dihe-out -101.28, 22.22 -64.94, 134.76 APE12-dist-na 9.8653 APE11-dist-na 11.3953 APE10-dist-na 16.0439 APE9-dist-out 12.7108 W659A,W777A,F794H None None XRAY 2.061 0.2 0.239 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obl TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OCCA O60674 537 808 1132.0 M57:1002 Type1 Pseudo DFGin 6.0618 13.5692 None -84.33, 174.58 -71.42, 156.44 -66.05, -27.79 338.24, 34.72 78.91, -171.69 out-na out 11.7166 Saltbr-na 999.0 HRD-in -79.87, -63.55 97.41, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.2604 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.17, -40.0 APE9-dihe-out -66.58, -22.02 APE8-dihe-out -86.2, 2.55 APE8-rot-na 295.02 APE67-dihe-out -102.04, 27.42 -65.31, 136.06 APE12-dist-na 9.937 APE11-dist-na 11.4119 APE10-dist-na 16.0003 APE9-dist-out 12.4336 W659A,W777A,F794H None None XRAY 2.03 0.227 0.272 A 289.0 268.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6occ TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6XJKA O60674 539 807 1132.0 V4D:901 Type1 Pseudo DFGin 7.0861 13.1101 None -82.39, -178.8 -73.6, 159.61 -82.47, -18.87 26.68, 148.75 79.98, -172.67 out-na out 10.9429 Saltbr-na 999.0 HRD-in -78.39, -61.79 94.59, -5.62 na-out-out SNCaoo out-out ActLoopNT-out 9.1768 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.63, -38.8 APE9-dihe-out -69.88, -19.28 APE8-dihe-out -90.06, 4.72 APE8-rot-na 291.97 APE67-dihe-out -100.24, 24.73 -62.96, 137.34 APE12-dist-na 9.833 APE11-dist-na 11.6512 APE10-dist-na 16.1346 APE9-dist-out 12.5371 W659A,W777A,F794H None None XRAY 2.024 0.229 0.273 A 289.0 265.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6xjk TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYOA O60674 539 808 1132.0 VPS:901 Type1 Pseudo DFGin 7.3133 13.2651 None -88.9, -179.5 -76.4, 155.67 -78.17, -11.76 25.61, 146.28 75.85, -168.38 in-na in 9.9397 Saltbr-na 999.0 HRD-in -78.1, -62.53 100.04, -11.32 na-out-out SNCaoo out-out ActLoopNT-out 9.47 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.05, -35.44 APE9-dihe-out -67.28, -21.98 APE8-dihe-out -89.32, 5.73 APE8-rot-na 292.48 APE67-dihe-out -104.2, 24.04 -63.78, 134.25 APE12-dist-na 10.0063 APE11-dist-na 11.4947 APE10-dist-na 16.0721 APE9-dist-out 12.6709 W659A,W777A,F794H None None XRAY 2.161 0.188 0.246 A 289.0 270.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7jyo TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYQA O60674 537 808 1132.0 VPJ:902 Type1 Pseudo DFGin 7.645 13.0055 None -92.98, -175.16 -77.54, 154.64 -78.8, -12.58 29.28, 143.4 74.39, -171.67 out-na out 13.0732 Saltbr-na 999.0 HRD-in -86.04, -59.14 96.24, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8115 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.31, -38.61 APE9-dihe-out -62.73, -23.3 APE8-dihe-out -89.27, 2.43 APE8-rot-na 292.66 APE67-dihe-out -102.33, 26.3 -62.62, 135.22 APE12-dist-na 10.0152 APE11-dist-na 11.5681 APE10-dist-na 16.1683 APE9-dist-out 12.8664 W659A,W777A,F794H None None XRAY 1.859 0.181 0.221 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7jyq TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7SZWA O60674 537 808 1132.0 DVY:901 Type1 Pseudo DFGin 6.4516 13.2599 None -82.57, 177.58 -73.21, 157.07 -69.74, -29.09 341.81, 33.15 77.93, -172.46 out-na out 12.3056 Saltbr-na 999.0 HRD-in -80.57, -59.83 95.34, -11.68 na-out-out SNCaoo out-out ActLoopNT-out 9.2552 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -37.85 APE9-dihe-out -63.74, -25.15 APE8-dihe-out -91.51, 8.03 APE8-rot-na 297.58 APE67-dihe-out -99.24, 24.79 -65.54, 137.42 APE12-dist-na 9.9259 APE11-dist-na 11.4265 APE10-dist-na 16.0645 APE9-dist-out 12.4083 W659A,W777A,F794H None None XRAY 1.906 0.195 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7szw TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PA O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.5356 13.4525 None -71.36, 169.62 -64.37, 154.19 -64.4, -34.91 335.03, 35.41 82.73, -164.25 out-na out 11.6251 Saltbr-na 999.0 HRD-in -78.49, -60.16 92.47, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.4113 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.7, -41.68 APE9-dihe-out -61.62, -27.73 APE8-dihe-out -89.13, 13.42 APE8-rot-na 292.46 APE67-dihe-out -104.69, 27.09 -67.15, 136.9 APE12-dist-na 10.1283 APE11-dist-na 11.4772 APE10-dist-na 16.1721 APE9-dist-out 12.8246 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t0p TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PB O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.5841 13.3753 None -73.4, 171.14 -67.99, 156.9 -65.04, -35.98 333.3, 36.74 84.58, -160.86 out-na out 11.6751 Saltbr-na 999.0 HRD-in -82.44, -59.87 91.7, -5.68 na-out-out SNCaoo out-out ActLoopNT-out 9.5252 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.77, -34.38 APE9-dihe-out -70.23, -20.91 APE8-dihe-out -95.01, 13.79 APE8-rot-na 294.77 APE67-dihe-out -106.03, 28.99 -67.37, 133.92 APE12-dist-na 10.0828 APE11-dist-na 11.624 APE10-dist-na 16.2602 APE9-dist-out 12.9567 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 B 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t0p TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T1TA O60674 536 809 1132.0 E8I:901 Type1 Pseudo DFGin 7.0745 13.1989 None -85.56, -179.34 -72.27, 154.59 -78.75, -8.81 22.02, 154.16 65.96, -165.49 out-na out 10.8121 Saltbr-na 999.0 HRD-in -83.69, -59.16 91.95, -7.4 na-out-out SNCaoo out-out ActLoopNT-out 9.7297 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.83, -40.65 APE9-dihe-out -65.84, -24.48 APE8-dihe-out -87.52, 8.41 APE8-rot-na 292.81 APE67-dihe-out -105.4, 28.45 -65.24, 133.84 APE12-dist-na 9.9478 APE11-dist-na 11.6118 APE10-dist-na 16.1823 APE9-dist-out 12.9375 W659A,W777A,F794H None None XRAY 2.08 0.183 0.228 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t1t TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.0102 13.3074 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.0967 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.1429 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.4338 APE10-dist-na 15.9334 APE9-dist-out 12.4277 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9h TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA3A O60674 536 812 1132.0 Q8U:60901 Type1 Pseudo DFGin 7.9449 13.7079 None -77.62, 172.89 -67.28, 156.81 -77.15, -9.78 24.71, 146.25 70.37, -168.01 out-na out 10.5812 Saltbr-na 999.0 HRD-in -73.02, -63.41 91.28, -5.41 na-out-out SNCaoo out-out ActLoopNT-out 8.8315 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.97, -37.88 APE9-dihe-out -69.87, -18.94 APE8-dihe-out -88.79, 5.92 APE8-rot-na 290.58 APE67-dihe-out -110.89, 28.54 -69.8, 129.69 APE12-dist-na 10.0415 APE11-dist-na 11.8896 APE10-dist-na 16.4253 APE9-dist-out 12.5092 W659A,W777A,F794H None None XRAY 1.4 0.175 0.197 A 289.0 277.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba3 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX0A O60674 536 808 1132.0 AQG:901 Type1 Pseudo DFGin 7.4123 13.4018 None -87.55, 174.91 -71.81, 159.18 -77.63, -11.45 24.29, 145.18 73.87, -172.91 in-na in 9.643 Saltbr-na 999.0 HRD-in -81.87, -61.41 94.19, -7.67 na-out-out SNCaoo out-out ActLoopNT-out 9.6084 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.42, -37.24 APE9-dihe-out -64.33, -22.0 APE8-dihe-out -89.33, 0.5 APE8-rot-na 287.44 APE67-dihe-out -103.06, 26.06 -59.07, 135.76 APE12-dist-na 9.8884 APE11-dist-na 11.5611 APE10-dist-na 16.1357 APE9-dist-out 12.686 W659A,W777A,F794H None None XRAY 1.85 0.179 0.228 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX1A O60674 537 808 1132.0 AD5:901 Type1 Pseudo DFGin 7.2822 13.5699 None -94.73, 174.88 -71.85, 156.73 -78.3, -7.64 23.96, 145.89 75.85, -176.26 in-na in 9.8513 Saltbr-na 999.0 HRD-in -83.17, -61.66 95.43, -4.68 na-out-out SNCaoo out-out ActLoopNT-out 9.7446 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.78, -38.61 APE9-dihe-out -63.17, -26.48 APE8-dihe-out -86.79, 6.17 APE8-rot-na 291.87 APE67-dihe-out -106.59, 26.74 -65.58, 134.04 APE12-dist-na 9.8512 APE11-dist-na 11.5504 APE10-dist-na 16.0568 APE9-dist-out 12.7733 W659A,W777A,F794H None None XRAY 1.5 0.169 0.191 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex1 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX2A O60674 536 808 1132.0 Q2Q:901 Type1 Pseudo DFGin 7.6828 13.3897 None -89.91, 173.83 -74.44, 158.35 -75.25, -10.25 27.64, 142.49 74.64, -169.3 in-na in 9.7258 Saltbr-na 999.0 HRD-in -84.46, -65.65 96.23, -6.71 na-out-out SNCaoo out-out ActLoopNT-out 9.5614 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.11, -41.46 APE9-dihe-out -59.07, -26.71 APE8-dihe-out -87.22, 3.02 APE8-rot-na 287.18 APE67-dihe-out -104.5, 26.8 -63.95, 134.55 APE12-dist-na 9.9758 APE11-dist-na 11.51 APE10-dist-na 16.1308 APE9-dist-out 12.6339 W659A,W777A,F794H None None XRAY 1.9 0.172 0.203 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex2 TYR_JAK2-1_HUMAN TYR 2.7e-64 222.9 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND5A O60674 536 809 1132.0 A1BXA:901 Type1 Pseudo DFGin 7.1967 13.4361 None -78.37, 174.28 -71.06, 155.85 -82.01, -13.03 28.16, 149.91 71.45, -157.96 out-na out 10.3765 Saltbr-na 999.0 HRD-in -81.65, -70.18 103.7, -2.47 na-out-out SNCaoo out-out ActLoopNT-out 9.4735 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -76.62, -29.08 APE9-dihe-out -76.41, -20.7 APE8-dihe-out -84.83, 10.94 APE8-rot-na 287.64 APE67-dihe-out -108.27, 36.81 -81.67, 130.11 APE12-dist-na 9.6535 APE11-dist-na 11.4413 APE10-dist-na 16.0178 APE9-dist-out 12.4531 None None None XRAY 2.4 0.214 0.278 A 280.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 9nd5 TYR_JAK2-1_HUMAN TYR 2.8e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND3A O60674 536 808 1132.0 A1BW6:901 Type1 Pseudo DFGin 5.9957 13.1158 None -64.1, 173.67 -70.95, 163.72 -78.01, -24.74 341.83, 32.74 77.82, -165.18 out-na out 11.374 Saltbr-na 999.0 HRD-in -84.19, -60.63 89.29, -1.33 na-out-out SNCaoo out-out ActLoopNT-out 9.1954 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.37, -39.11 APE9-dihe-out -58.8, -29.7 APE8-dihe-out -87.32, 4.81 APE8-rot-na 289.91 APE67-dihe-out -104.68, 28.28 -65.86, 133.14 APE12-dist-na 9.6569 APE11-dist-na 11.4611 APE10-dist-na 16.0024 APE9-dist-out 12.276 None None None XRAY 1.62 0.189 0.22 A 283.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 9nd3 TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5TQ3A O60674 843 1132 1132.0 7GZ:4000 Type1.5_Back Inactive DFGin 6.7366 14.7991 None 172.87, 131.46 -138.34, 98.39 -97.83, 27.37 287.51, 86.01 -80.9, -8.4 in-in in 8.5838 Saltbr-in 2.8363 HRD-in -60.87, -46.98 70.99, 1.64 in-in-in SNCiii in-in ActLoopNT-in 2.9485 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.52, 122.1 APE9-dihe-in -107.12, 143.94 APE8-dihe-in -76.54, 73.52 APE8-rot-na 28.78 APE67-dihe-in -71.43, -5.04 -57.67, -36.56 APE12-dist-na 9.1516 APE11-dist-na 10.6276 APE10-dist-na 11.3857 APE9-dist-in 7.3259 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.69 0.219 0.271 A 304.0 284.0 6 31 29 2 [[545, 807], [849, 1125]] 2.0 5tq3 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5TQ3B O60674 843 1132 1132.0 7GZ:4001 Type1.5_Back Inactive DFGin 6.7371 14.7977 None 175.33, 157.26 -141.41, 99.71 -97.33, 27.05 288.19, 85.47 -80.15, -9.61 in-in in 8.5742 Saltbr-in 2.8801 HRD-in -62.69, -46.43 69.37, 2.93 in-in-in SNCiii in-in ActLoopNT-in 2.9552 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.61, 127.26 APE9-dihe-in -88.47, 146.55 APE8-dihe-in -72.07, 80.22 APE8-rot-na 34.9 APE67-dihe-in -69.96, -5.59 -60.36, -37.68 APE12-dist-na 12.1436 APE11-dist-na 10.8771 APE10-dist-na 11.8755 APE9-dist-in 7.1992 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.69 0.219 0.271 B 304.0 287.0 3 31 31 0 [[545, 807], [849, 1125]] 2.0 5tq3 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR KDR VGFR2_HUMAN 1VR2A P35968 820 1168 1356.0 No_ligand No_ligand Inactive DFGin 6.1971 12.2007 None -132.36, 167.84 67.89, 27.54 -86.08, 999.0 49.78, 130.84 999.0, 999.0 in-in in 7.7298 Saltbr-in 2.9904 HRD-in -66.37, -43.4 76.06, -15.34 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.43, 155.04 APE9-dihe-in -108.73, 90.95 APE8-dihe-out -47.33, -14.52 APE8-rot-na 323.83 APE67-dihe-in -64.29, -7.8 -69.97, -29.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.4665 E990V PTR1059 PTR1059 XRAY 2.4 0.215 999.0 A 316.0 275.0 24 30 14 16 [[834, 1162]] 1.0 1vr2 TYR_KDR_HUMAN TYR 4.1e-100 340.3 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR LYN LYN_HUMAN 3A4OX P07948 238 505 512.0 STU:60902 Type1 Inactive DFGin 6.6497 15.5814 None -103.69, -177.97 54.14, 148.85 -166.58, 42.86 276.85, 106.11 -75.66, -40.91 in-in in 9.1227 Saltbr-in 3.2202 HRD-in -82.15, -55.06 93.66, -27.17 in-in-out SNCiio in-out ActLoopNT-in 2.8615 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out -155.78, -36.41 APE9-dihe-out 3.09, -67.88 APE8-dihe-in -48.66, 80.66 APE8-rot-na 28.53 APE67-dihe-in -67.02, 39.44 -53.16, -65.62 APE12-dist-na 7.583 APE11-dist-na 3.3978 APE10-dist-na 8.537 APE9-dist-in 6.4504 None None None XRAY 3.0 0.293 0.324 X 286.0 259.0 9 29 20 9 [[247, 499]] 1.0 3a4o TYR_LYN_HUMAN TYR 1.2e-95 325.7 1.0 260.0 260.0 384 385 386 388 390 275 290 294 364 366 365 367.0 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
TYR MERTK MERTK_HUMAN 5TD2B Q12866 577 861 999.0 No_ligand No_ligand Inactive DFGin 6.7934 13.1159 None -144.11, 174.62 61.92, 63.15 -77.51, 999.0 303.45, 94.64 999.0, 999.0 out-out out 13.3511 Saltbr-out 12.416 HRD-in -68.4, -50.94 72.94, 5.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.34 APE8-rot-na 32.97 APE67-dihe-in -69.61, -9.75 -67.34, -19.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.251 0.3 B 285.0 242.0 43 30 10 20 [[587, 856]] 1.0 5td2 TYR_MERTK_HUMAN TYR 2.9e-92 314.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MH7B Q12866 577 862 999.0 No_ligand No_ligand Inactive DFGin 6.2369 12.8082 None -148.47, -179.73 64.64, 46.7 -122.89, 999.0 48.11, 70.87 999.0, 999.0 out-out out 12.8965 Saltbr-out 12.9259 HRD-in -78.94, -52.07 71.09, 5.48 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.45 APE8-rot-na 30.55 APE67-dihe-in -77.17, 1.49 -58.85, -30.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.51 0.228 0.279 B 313.0 255.0 31 30 10 20 [[587, 856]] 1.0 4mh7 TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TC0B Q12866 578 861 999.0 No_ligand No_ligand Inactive DFGin 5.9768 12.8785 None -140.01, 177.82 66.06, 34.51 -92.54, 999.0 25.62, 68.77 999.0, 999.0 out-out out 12.9501 Saltbr-out 9.125 HRD-in -84.36, -52.52 74.32, 6.07 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.67 APE8-rot-na 31.87 APE67-dihe-in -69.09, -5.19 -56.41, -41.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.24 0.229 0.262 B 314.0 250.0 34 30 10 20 [[587, 856]] 1.0 5tc0 TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB0A Q12866 571 862 999.0 No_ligand No_ligand Inactive DFGin 6.6237 14.0135 None -143.7, 175.11 61.44, 47.67 -68.22, 999.0 316.54, 102.57 999.0, 999.0 out-out out 13.2638 Saltbr-out 14.3456 HRD-in -75.07, -54.59 74.43, 4.28 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.53 APE8-rot-na 33.09 APE67-dihe-in -75.24, -3.15 -51.47, -40.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.74 0.202 0.246 A 298.0 267.0 25 30 10 20 [[587, 856]] 1.0 7ab0 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TD2A Q12866 577 861 999.0 7AE:1000 Type1 Inactive DFGin 6.1343 13.6506 None -143.3, 174.43 65.95, 82.51 -104.11, 999.0 312.2, 105.07 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.96, -51.07 72.28, 6.41 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 97.89 APE8-rot-na 25.82 APE67-dihe-in -75.54, -1.44 -65.62, -42.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.251 0.3 A 285.0 240.0 45 30 10 20 [[587, 856]] 1.0 5td2 TYR_MERTK_HUMAN TYR 2.9e-92 314.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OAMB Q12866 576 862 999.0 V6H:60901 Type1 Inactive DFGin 7.0066 13.4567 None -146.0, 178.63 58.31, 50.5 -120.77, 999.0 46.98, 69.39 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.67, -62.84 85.61, -10.13 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 97.98 APE8-dihe-in -79.78, 85.21 APE8-rot-na 33.46 APE67-dihe-in -75.72, -1.35 -61.95, -25.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5175 None None None XRAY 2.65 0.224 0.257 B 296.0 250.0 37 30 11 19 [[587, 856]] 1.0 7oam TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3TCPA Q12866 577 863 999.0 CKJ:1 Type1 Inactive DFGin 6.2033 12.8934 None -136.14, -178.38 58.94, 40.23 -104.0, 999.0 45.8, 90.86 999.0, 999.0 out-out out 13.0698 Saltbr-out 10.0871 HRD-in -71.3, -54.4 78.76, -16.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.51 APE8-rot-na 24.96 APE67-dihe-in -68.45, -1.97 -46.97, -39.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.69 0.228 0.298 A 313.0 256.0 31 30 10 20 [[587, 856]] 1.0 3tcp TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3TCPB Q12866 576 861 999.0 CKJ:2 Type1 Inactive DFGin 6.542 12.7247 None -151.12, -175.9 57.3, 28.48 -93.29, 999.0 44.8, 72.64 999.0, 999.0 out-none out 12.0114 Saltbr-none 999.0 HRD-in -62.48, -45.95 68.1, -10.21 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -34.04 APE8-dihe-in -94.24, 71.38 APE8-rot-na 31.8 APE67-dihe-in -76.89, -2.28 -48.4, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2614 None None None XRAY 2.69 0.228 0.298 B 313.0 250.0 36 30 11 19 [[587, 856]] 1.0 3tcp TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4M3QA Q12866 578 861 999.0 24K:906 Type1 Inactive DFGin 5.9623 13.2718 None -156.18, 179.21 59.94, 63.59 -121.26, 999.0 26.4, 60.96 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -76.83, -49.1 68.2, 10.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -8.28 APE8-rot-na 30.83 APE67-dihe-in -76.46, 5.82 -62.87, -37.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.718 0.248 0.296 A 313.0 243.0 41 30 10 20 [[587, 856]] 1.0 4m3q TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MH7A Q12866 577 861 999.0 MH7:906 Type1 Inactive DFGin 6.6728 13.7335 None -149.88, -177.32 66.64, 46.5 -124.55, 999.0 44.22, 68.98 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.51, -51.41 72.09, 3.88 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.58 APE8-rot-na 30.75 APE67-dihe-in -78.5, 1.01 -58.56, -31.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.51 0.228 0.279 A 313.0 248.0 37 30 10 20 [[587, 856]] 1.0 4mh7 TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MHAB Q12866 577 862 999.0 4MH:905 Type1 Inactive DFGin 5.588 13.1656 None -164.91, -178.11 62.75, 50.05 -120.6, 999.0 47.74, 75.91 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -87.47, -43.02 65.67, 7.44 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 102.4 APE8-rot-na 29.27 APE67-dihe-in -76.83, 2.21 -113.8, -35.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.246 0.294 B 313.0 246.0 40 30 10 20 [[587, 856]] 1.0 4mha TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5K0KB Q12866 577 862 999.0 6Q1:904 Type1 Inactive DFGin 6.1892 13.3888 None -144.02, -179.34 56.66, 60.57 -135.11, 999.0 52.83, 74.37 999.0, 999.0 out-out out 12.8302 Saltbr-out 9.0057 HRD-in -81.18, -49.68 74.51, -7.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.62 APE8-rot-na 27.52 APE67-dihe-in -73.94, -3.99 -57.79, -40.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.545 0.203 0.254 B 313.0 248.0 38 30 10 20 [[587, 856]] 1.0 5k0k TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TC0A Q12866 578 861 999.0 79Y:1100 Type1 Inactive DFGin 5.868 13.0928 None -140.95, 176.68 72.06, 53.5 -127.68, 999.0 35.95, 63.07 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.04, -52.33 70.75, 9.58 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 51.99 APE8-dihe-in -70.22, 110.63 APE8-rot-na 29.77 APE67-dihe-in -71.61, -2.78 -54.4, -35.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.1839 None None None XRAY 2.24 0.229 0.262 A 314.0 238.0 46 30 11 19 [[587, 856]] 1.0 5tc0 TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5U6CA Q12866 572 864 999.0 7YS:9001 Type1 Inactive DFGin 6.5138 13.097 None -140.41, -178.19 73.14, -58.25 59.05, 38.04 321.05, 119.16 47.3, 38.19 out-out out 12.2383 Saltbr-out 10.4104 HRD-in -76.31, -59.9 77.64, -5.13 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -19.89 APE8-rot-na 24.77 APE67-dihe-in -66.57, -0.63 -47.81, -46.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.214 0.257 A 315.0 272.0 21 30 13 17 [[587, 856]] 1.0 5u6c TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5U6CB Q12866 575 862 999.0 7YS:9001 Type1 Inactive DFGin 5.7559 13.3901 None -146.75, -178.14 49.0, 37.86 -93.39, 999.0 43.6, 77.83 999.0, 999.0 out-out out 13.8564 Saltbr-out 11.1074 HRD-in -77.29, -57.91 76.71, -6.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.75 APE8-dihe-in -83.33, 57.19 APE8-rot-na 31.94 APE67-dihe-in -71.79, -2.99 -38.38, -48.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0609 None None None XRAY 2.1 0.214 0.257 B 315.0 257.0 31 30 11 19 [[587, 856]] 1.0 5u6c TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB1A Q12866 571 862 999.0 C6F:60901 Type1 Inactive DFGin 5.8722 13.5268 None -150.27, 178.21 48.78, 48.66 -107.87, 999.0 41.9, 85.18 999.0, 999.0 out-out out 12.8443 Saltbr-out 9.5657 HRD-in -84.92, -52.07 85.67, -41.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.29 APE8-rot-na 36.31 APE67-dihe-in -65.53, -14.5 -57.08, -42.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.93 0.237 0.298 A 298.0 267.0 25 30 10 20 [[587, 856]] 1.0 7ab1 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB2A Q12866 571 862 999.0 R6N:60901 Type1 Inactive DFGin 6.3276 13.5883 None -148.22, 175.53 55.93, 53.34 -74.83, 999.0 329.09, 104.95 999.0, 999.0 out-out out 13.2033 Saltbr-out 14.5703 HRD-in -79.16, -56.47 81.41, -4.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 64.62 APE8-rot-na 36.54 APE67-dihe-in -78.04, -6.9 -58.38, -34.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.78 0.196 0.25 A 298.0 267.0 25 30 10 20 [[587, 856]] 1.0 7ab2 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AVZA Q12866 571 862 999.0 S4N:60901 Type1 Inactive DFGin 6.2693 13.5904 None -145.45, 176.2 52.56, 50.67 -72.23, 999.0 339.86, 87.13 999.0, 999.0 out-out out 12.9842 Saltbr-out 9.9233 HRD-in -69.09, -58.13 78.41, -16.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.96 APE8-rot-na 31.06 APE67-dihe-in -76.22, 2.71 -47.31, -44.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.04 0.207 0.229 A 298.0 265.0 27 30 10 20 [[587, 856]] 1.0 7avz TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW0A Q12866 571 862 999.0 S4Q:60901 Type1 Inactive DFGin 6.0743 13.887 None -146.33, 175.15 58.08, 44.92 -106.5, 999.0 37.04, 79.3 999.0, 999.0 out-out out 13.1591 Saltbr-out 9.8931 HRD-in -73.83, -55.86 76.62, -13.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.76 APE8-rot-na 19.28 APE67-dihe-in -68.82, -6.08 -45.38, -39.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.893 0.204 0.233 A 298.0 266.0 26 30 10 20 [[587, 856]] 1.0 7aw0 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW3A Q12866 571 862 999.0 S4Z:60901 Type1 Inactive DFGin 6.1357 13.4921 None -141.96, 175.75 54.61, 48.83 -104.75, 999.0 29.07, 73.23 999.0, 999.0 out-out out 13.2531 Saltbr-out 10.1666 HRD-in -76.56, -55.94 78.32, -15.64 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.13 APE8-rot-na 30.36 APE67-dihe-in -72.86, -3.93 -46.59, -40.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.99 0.217 0.245 A 298.0 266.0 26 30 10 20 [[587, 856]] 1.0 7aw3 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7M5ZA Q12866 577 862 999.0 YR7:901 Type1 Inactive DFGin 5.6814 14.1735 None -159.0, -169.59 47.7, 65.14 -69.86, 999.0 300.1, 112.68 999.0, 999.0 in-out in 9.2564 Saltbr-out 6.024 HRD-in -77.96, -43.12 69.37, -0.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 13.83 APE8-rot-na 32.06 APE67-dihe-in -66.59, -6.13 -57.74, -32.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.06 0.265 0.297 A 313.0 263.0 23 30 10 20 [[587, 856]] 1.0 7m5z TYR_MERTK_HUMAN TYR 2.7e-92 314.7 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 6MEPB Q12866 578 862 999.0 9VS:904 Type1.5_Back Inactive DFGin 6.137 13.7512 None -149.56, -177.34 59.65, 39.31 -110.56, 999.0 52.79, 83.98 999.0, 999.0 out-out out 12.835 Saltbr-out 11.8071 HRD-out -99.49, 96.49 -80.13, -3.87 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.16 APE8-rot-na 30.37 APE67-dihe-in -67.86, -3.3 -78.71, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.893 0.21 0.268 B 313.0 236.0 49 30 10 20 [[587, 856]] 1.0 6mep TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3EFKA P08581 1054 1351 1390.0 MT4:1 Type1.5_Front Inactive DFGin 5.0636 14.0927 None -134.75, -178.01 61.2, 27.83 -81.51, 999.0 42.72, 82.19 999.0, 999.0 out-out out 12.8128 Saltbr-out 7.9409 HRD-in -70.71, -51.36 83.62, -19.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 26.89 APE8-rot-na 29.1 APE67-dihe-in -75.12, -5.25 -59.44, -32.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L1272L None None XRAY 2.2 0.257 0.292 A 310.0 276.0 22 32 10 22 [[1078, 1339]] 1.0 3efk TYR_MET_HUMAN TYR 7e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKB P08581 1054 1351 1390.0 MT4:2 Type1.5_Front Inactive DFGin 5.1715 14.1711 None -136.11, -178.89 60.83, 31.64 -88.75, 999.0 42.99, 77.64 999.0, 999.0 out-out out 12.549 Saltbr-out 7.6229 HRD-in -66.0, -59.6 86.12, -12.02 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 28.71 APE8-rot-na 33.98 APE67-dihe-in -75.58, -3.26 -55.05, -32.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L1272L None None XRAY 2.2 0.257 0.292 B 310.0 272.0 26 32 10 22 [[1078, 1339]] 1.0 3efk TYR_MET_HUMAN TYR 7e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4PMTA P04629 501 787 796.0 31Y:60801 Type1 Inactive DFGin 6.1314 14.794 None -112.67, -17.01 -137.68, 145.04 -146.35, 999.0 322.04, 80.71 999.0, 999.0 in-out in 9.8065 Saltbr-out 3.6332 HRD-in -75.33, -51.24 80.98, -15.04 out-out-in SNCooi out-in ActLoopNT-out 15.615 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.06, 128.33 APE9-dihe-in -117.66, 131.56 APE8-dihe-in -80.54, 63.91 APE8-rot-na 31.59 APE67-dihe-in -62.62, -22.15 -50.58, -36.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2177 None None None XRAY 2.1 0.186 0.209 A 291.0 269.0 18 30 25 5 [[510, 783]] 1.0 4pmt TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5I8AA P04629 501 787 796.0 69C:60801 Type1 Inactive DFGin 6.738 14.3896 None -97.16, -113.31 -48.28, 144.89 -102.36, 10.49 289.66, 94.22 178.06, 999.0 in-in in 9.6286 Saltbr-in 3.266 HRD-in -70.07, -53.33 85.54, -20.79 in-out-in SNCioi out-in ActLoopNT-out 17.1271 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.82, 123.59 APE9-dihe-in -112.87, 128.48 APE8-dihe-in -77.41, 62.86 APE8-rot-na 29.5 APE67-dihe-in -66.17, -22.6 -48.87, -35.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2452 None None None XRAY 2.33 0.18 0.209 A 296.0 266.0 21 30 26 4 [[510, 783]] 1.0 5i8a TYR_NTRK1_HUMAN TYR 1.7e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6IQNA P04629 502 790 796.0 AQ6:60801 Type1 Inactive DFGin 7.14 15.1103 None -103.61, -29.7 -117.2, -70.49 62.55, 999.0 316.84, 95.5 999.0, 999.0 in-out in 9.7917 Saltbr-out 4.8101 HRD-in -72.08, -53.46 85.54, -25.89 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.52, 109.29 APE9-dihe-in -102.41, 128.27 APE8-dihe-in -77.64, 69.03 APE8-rot-na 26.82 APE67-dihe-in -69.77, -22.47 -58.81, -29.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3302 None None None XRAY 2.54 0.228 0.287 A 296.0 271.0 18 30 18 12 [[510, 783]] 1.0 6iqn TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 7XAFA P04629 498 796 796.0 FKT:801 Type1 Inactive DFGin 10.9726 15.5303 None -141.15, 137.13 74.8, 177.08 49.53, -82.17 307.2, 139.07 -1.5, 80.75 in-out in 9.4808 Saltbr-out 3.7007 HRD-out -81.39, 105.98 -86.3, -0.43 out-out-in SNCooi out-in ActLoopNT-out 15.4378 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.83, 144.52 APE9-dihe-in -128.89, 123.51 APE8-dihe-in -76.16, 66.1 APE8-rot-na 29.0 APE67-dihe-in -71.14, -21.57 -60.15, -25.01 APE12-dist-na 15.0229 APE11-dist-na 14.3354 APE10-dist-na 10.4171 APE9-dist-in 7.3626 None None None XRAY 3.001 0.25 0.299 A 299.0 287.0 12 30 30 0 [[510, 783]] 1.0 7xaf TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6J5LA P04629 502 790 796.0 B9C:60801 Type1 Inactive DFGin 6.1274 13.7929 None -112.0, -17.65 -146.4, 142.64 -117.9, -119.21 307.69, 78.13 -102.52, 999.0 in-in in 9.3453 Saltbr-in 3.4221 HRD-out -88.88, 113.33 -93.5, 4.21 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.51, 126.2 APE9-dihe-in -111.04, 133.44 APE8-dihe-in -88.74, 66.42 APE8-rot-na 38.43 APE67-dihe-in -63.3, -23.33 -52.55, -36.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.9327 None None None XRAY 2.3 0.224 0.251 A 303.0 278.0 11 30 23 7 [[510, 783]] 1.0 6j5l TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PMEB P04629 499 791 796.0 OOY:802 Type1 Inactive DFGin 8.0413 12.7752 None -108.23, 50.17 -34.62, -93.7 -97.7, 157.35 268.23, 140.64 158.45, -156.12 in-out in 9.6869 Saltbr-out 4.3617 HRD-in -75.61, -49.56 82.71, -16.4 out-out-none SNCoon out-none ActLoopNT-out 15.6778 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.79 APE9-dihe-in -136.64, 129.71 APE8-dihe-in -72.47, 62.28 APE8-rot-na 30.59 APE67-dihe-in -74.1, -16.42 -50.47, -31.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7569 APE9-dist-in 7.0187 None SEP677 SEP677 XRAY 3.0 0.259 0.315 B 311.0 271.0 22 30 25 5 [[510, 783]] 1.0 6pme TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.3285 15.1025 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.6981 Saltbr-in 3.2532 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4955 None None None XRAY 2.864 0.22 0.277 A 320.0 264.0 32 30 11 19 [[510, 783]] 1.0 9dai TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 7VKOA P04629 502 793 796.0 7GI:60801 Type1 Inactive DFGin 6.3309 13.7935 None -121.29, -23.19 -130.55, 158.61 -131.43, -91.62 300.81, 84.28 -89.58, -178.74 in-out in 9.271 Saltbr-out 4.8438 HRD-out -83.55, 115.94 -93.33, 10.49 out-out-in SNCooi out-in ActLoopNT-out 15.2129 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.01, 135.08 APE9-dihe-in -120.4, 150.84 APE8-dihe-in -84.95, 78.96 APE8-rot-na 37.61 APE67-dihe-in -53.21, -25.59 -47.58, -54.99 APE12-dist-na 10.7383 APE11-dist-na 11.7728 APE10-dist-na 9.7313 APE9-dist-in 6.3483 None None None XRAY 2.9 0.188 0.267 A 326.0 292.0 0 30 30 0 [[510, 783]] 1.0 7vko TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4AOJB P04629 500 791 796.0 V4Z:900 Type1 Inactive DFGin 7.1015 14.487 None -112.8, -14.1 -146.85, 148.75 -118.66, 999.0 304.25, 74.79 999.0, 999.0 in-out in 9.7738 Saltbr-out 3.7833 HRD-in -81.07, -46.03 78.05, -27.65 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.18 APE8-dihe-in -83.87, 63.88 APE8-rot-na 24.55 APE67-dihe-in -64.26, -27.58 -47.61, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2365 None None None XRAY 2.75 0.221 0.242 B 329.0 258.0 34 30 11 19 [[510, 783]] 1.0 4aoj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK2 NTRK2_HUMAN 4AT3A Q16620 527 822 822.0 LTI:61839 Type1 Inactive DFGin 6.9991 14.7396 None -152.42, -173.22 72.78, -62.99 65.94, 17.52 310.83, 124.61 77.58, 6.11 out-out out 10.154 Saltbr-out 5.3168 HRD-in -64.12, -49.63 78.79, -14.53 out-out-in SNCooi out-in ActLoopNT-out 14.2538 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.1, 112.61 APE9-dihe-in -128.93, 146.94 APE8-dihe-in -81.25, 69.04 APE8-rot-na 31.63 APE67-dihe-in -62.22, -21.09 -43.86, -43.94 APE12-dist-na 17.2682 APE11-dist-na 12.9856 APE10-dist-na 11.6967 APE9-dist-in 6.9412 None None None XRAY 1.77 0.2 0.224 A 299.0 286.0 10 30 28 2 [[538, 809]] 1.0 4at3 TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
TYR PTK2 FAK1_HUMAN 2IJMA Q05397 414 688 1052.0 ATP:690 ATPlike Inactive DFGin 5.3348 15.2552 None -130.4, -10.41 -96.6, 92.35 -115.09, 154.36 308.92, 97.78 84.66, -9.12 in-in in 7.6024 Saltbr-in 2.5443 HRD-in -77.84, -47.69 90.07, -21.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -43.55 APE8-dihe-in -70.98, 54.52 APE8-rot-na 26.91 APE67-dihe-in -71.31, -14.5 -49.75, -42.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5309 None None None XRAY 2.187 0.211 0.271 A 281.0 260.0 15 29 14 15 [[422, 678]] 1.0 2ijm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 7PI4DDD Q05397 415 687 1052.0 No_ligand No_ligand Inactive DFGin 6.6416 15.7596 None -89.21, -168.8 -53.97, 129.66 -63.34, -43.26 292.53, 5.46 -58.42, -48.1 in-in in 7.4592 Saltbr-in 2.722 HRD-in -72.06, -49.67 76.25, -8.72 in-out-out SNCioo out-out ActLoopNT-out 10.4837 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 141.81 APE9-dihe-in -72.54, 128.52 APE8-dihe-in -81.98, 69.32 APE8-rot-na 34.58 APE67-dihe-in -74.94, -9.99 -55.31, -40.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.0953 APE9-dist-out 8.6378 None None None XRAY 2.24 0.198 0.251 DDD 273.0 264.0 9 29 20 9 [[422, 678]] 1.0 7pi4 TYR_PTK2_HUMAN TYR 3.1e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 9SDIB Q05397 414 685 1052.0 No_ligand No_ligand Inactive DFGin 4.0046 13.1703 None -97.64, -137.83 -54.67, 146.24 -100.48, 130.01 327.08, 92.25 63.05, 999.0 in-out in 8.1063 Saltbr-out 8.294 HRD-in -82.43, -51.16 74.28, 13.4 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.88 APE8-dihe-in -70.36, 61.66 APE8-rot-na 27.15 APE67-dihe-in -67.38, -13.24 -53.44, -40.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9784 None None None XRAY 2.53 0.184 0.241 B 277.0 255.0 17 29 12 17 [[422, 678]] 1.0 9sdi TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 3BZ3A Q05397 414 689 1052.0 YAM:1 Type1 Inactive DFGin 6.6719 15.8496 None -79.02, -179.99 -56.66, 136.15 -73.84, -38.07 287.89, 7.91 -61.02, -47.25 in-in in 7.5275 Saltbr-in 2.589 HRD-in -85.54, -56.7 90.17, -10.54 in-out-out SNCioo out-out ActLoopNT-out 10.5565 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.15 APE8-dihe-in -80.58, 72.72 APE8-rot-na 30.9 APE67-dihe-in -70.02, -11.94 -54.79, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1297 None None None XRAY 2.2 0.16 0.234 A 276.0 259.0 17 29 16 13 [[422, 678]] 1.0 3bz3 TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU9A Q05397 414 685 1052.0 4GU:701 Type1 Inactive DFGin 6.6989 15.7008 None -123.83, 12.04 -117.35, 108.51 -134.16, 999.0 294.29, 94.21 999.0, 999.0 in-in in 7.769 Saltbr-in 3.4919 HRD-in -72.07, -46.62 76.1, -11.95 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.49 APE8-dihe-in -81.89, 65.04 APE8-rot-na 31.19 APE67-dihe-in -69.72, -10.34 -49.89, -42.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6556 None None None XRAY 2.4 0.18 0.221 A 279.0 252.0 20 29 11 18 [[422, 678]] 1.0 4gu9 TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4KABA Q05397 412 686 1052.0 4KA:701 Type1 Inactive DFGin 6.3904 15.555 None -111.52, -14.16 -107.87, 122.87 -138.65, 999.0 293.6, 93.91 999.0, 999.0 in-in in 7.7049 Saltbr-in 3.0591 HRD-in -73.14, -43.25 75.58, -10.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.68 APE8-dihe-in -81.37, 68.28 APE8-rot-na 28.59 APE67-dihe-in -69.97, -11.06 -55.99, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5399 None None None XRAY 2.71 0.173 0.219 A 279.0 255.0 20 29 11 18 [[422, 678]] 1.0 4kab TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6I8ZA Q05397 414 688 1052.0 H82:701 Type1 Inactive DFGin 6.534 15.7387 None -73.65, -177.37 -59.05, 135.57 -69.93, -28.35 299.91, 168.26 -68.89, -44.51 in-in in 7.6007 Saltbr-in 2.8041 HRD-in -70.2, -51.5 74.46, -8.27 in-out-out SNCioo out-out ActLoopNT-out 10.5195 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.99 APE8-dihe-in -84.17, 66.78 APE8-rot-na 36.24 APE67-dihe-in -65.96, -15.87 -53.48, -40.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4163 None None None XRAY 1.99 0.185 0.222 A 281.0 261.0 14 29 15 14 [[422, 678]] 1.0 6i8z TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4I4EA Q05397 414 686 1052.0 1BQ:1000 Type1 Inactive DFGin 6.7896 16.342 None -103.61, -97.99 -1.1, -106.34 55.03, 999.0 299.48, 75.74 999.0, 999.0 in-out in 7.6984 Saltbr-out 3.7485 HRD-in -79.84, -49.84 80.8, -2.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.29 APE8-dihe-in -79.67, 64.72 APE8-rot-na 33.35 APE67-dihe-in -67.06, -11.75 -53.27, -42.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2632 None None None XRAY 1.55 0.166 0.189 A 281.0 254.0 19 29 11 18 [[422, 678]] 1.0 4i4e TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU6A Q05397 414 686 1052.0 10N:701 Type1 Inactive DFGin 6.7252 15.7213 None -78.95, -178.49 -53.69, 136.88 -71.82, -34.41 298.6, 168.4 -65.26, -49.08 in-in in 7.5214 Saltbr-in 2.6966 HRD-in -71.62, -48.61 84.03, -17.12 in-out-out SNCioo out-out ActLoopNT-out 9.6384 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -143.19, 149.54 APE9-dihe-in -51.38, 136.95 APE8-dihe-in -84.93, 56.73 APE8-rot-na 35.61 APE67-dihe-in -63.59, -13.44 -54.64, -43.26 APE12-dist-na 13.4175 APE11-dist-na 11.7698 APE10-dist-na 15.2281 APE9-dist-out 9.3756 None None None XRAY 1.95 0.171 0.194 A 282.0 271.0 2 29 29 0 [[422, 678]] 1.0 4gu6 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU6B Q05397 415 686 1052.0 10N:701 Type1 Inactive DFGin 6.7322 15.9506 None -79.45, -179.1 -51.77, 131.29 -67.64, -33.77 299.56, 166.92 -65.8, -45.35 in-in in 7.5272 Saltbr-in 2.7282 HRD-in -73.02, -50.64 78.02, -11.87 in-out-out SNCioo out-out ActLoopNT-out 10.8619 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.41 APE8-dihe-in -75.09, 60.15 APE8-rot-na 31.47 APE67-dihe-in -63.51, -13.22 -52.64, -44.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2437 None None None XRAY 1.95 0.171 0.194 B 282.0 258.0 14 29 15 14 [[422, 678]] 1.0 4gu6 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YOJA Q05397 414 686 1052.0 P4N:701 Type1 Inactive DFGin 6.5173 15.9644 None -76.38, -175.19 -62.53, 137.68 -71.29, -34.87 295.0, 178.59 -63.41, -49.08 in-in in 7.4187 Saltbr-in 2.765 HRD-in -74.52, -48.86 75.74, -8.06 in-out-none SNCion out-none ActLoopNT-out 10.504 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.61 APE8-dihe-in -85.09, 65.79 APE8-rot-na 30.31 APE67-dihe-in -64.59, -10.84 -48.78, -45.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7984 None None None XRAY 1.361 0.172 0.198 A 282.0 259.0 14 29 15 14 [[422, 678]] 1.0 6yoj TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1A Q05397 415 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.7725 15.904 None -76.89, 179.45 -55.75, 133.99 -70.6, -39.73 296.27, 174.79 -61.86, -42.84 in-in in 7.5464 Saltbr-in 2.9126 HRD-in -71.31, -56.22 78.91, -8.0 in-out-out SNCioo out-out ActLoopNT-out 12.1536 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -50.8 APE9-dihe-in -136.97, 142.61 APE8-dihe-in -82.64, 66.53 APE8-rot-na 31.58 APE67-dihe-in -67.94, -11.22 -48.21, -42.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.4702 APE9-dist-out 8.2827 None None None XRAY 1.784 0.184 0.214 A 282.0 269.0 3 29 26 3 [[422, 678]] 1.0 6yq1 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1B Q05397 411 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.896 16.0083 None -76.83, 179.03 -54.23, 132.73 -71.29, -38.79 295.55, 174.7 -61.35, -42.29 in-in in 7.5298 Saltbr-in 2.8646 HRD-in -73.31, -54.59 78.37, -7.32 in-out-out SNCioo out-out ActLoopNT-out 12.0232 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -48.66, 142.89 APE9-dihe-in -137.31, 146.9 APE8-dihe-in -83.8, 68.09 APE8-rot-na 31.86 APE67-dihe-in -70.2, -9.5 -48.58, -42.33 APE12-dist-na 13.3986 APE11-dist-na 16.8491 APE10-dist-na 14.8369 APE9-dist-out 8.2536 None None None XRAY 1.784 0.184 0.214 B 282.0 273.0 3 29 26 3 [[422, 678]] 1.0 6yq1 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1C Q05397 412 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.5807 15.8409 None -75.66, -177.24 -55.77, 133.76 -67.84, -41.72 295.72, 176.78 -60.36, -44.8 in-in in 7.6154 Saltbr-in 2.8575 HRD-in -71.08, -53.73 81.02, -10.73 in-out-out SNCioo out-out ActLoopNT-out 10.6328 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -15.64 APE9-dihe-in -96.3, 121.87 APE8-dihe-in -82.84, 65.74 APE8-rot-na 33.11 APE67-dihe-in -65.58, -12.51 -46.04, -44.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.9889 APE9-dist-out 8.8324 None None None XRAY 1.784 0.184 0.214 C 282.0 264.0 11 29 18 11 [[422, 678]] 1.0 6yq1 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1D Q05397 415 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.6569 15.854 None -76.76, -177.88 -55.33, 133.74 -70.22, -39.58 296.95, 175.58 -62.46, -41.81 in-in in 7.5231 Saltbr-in 2.8813 HRD-in -70.74, -53.46 79.06, -11.18 in-out-out SNCioo out-out ActLoopNT-out 11.8128 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -83.88, 65.98 APE8-rot-na 32.0 APE67-dihe-in -68.39, -9.16 -46.59, -43.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4303 None None None XRAY 1.784 0.184 0.214 D 282.0 258.0 14 29 15 14 [[422, 678]] 1.0 6yq1 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9A Q05397 415 686 1052.0 P9K:701 Type1 Inactive DFGin 6.6927 15.6561 None -72.52, -178.45 -57.73, 135.79 -72.85, -37.79 298.07, 168.43 -63.0, -44.27 in-in in 7.5374 Saltbr-in 2.7557 HRD-in -68.47, -56.13 84.19, -11.31 in-out-out SNCioo out-out ActLoopNT-out 11.9709 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.92 APE8-dihe-in -80.86, 65.41 APE8-rot-na 32.51 APE67-dihe-in -65.96, -9.35 -56.05, -39.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8068 None None None XRAY 1.925 0.193 0.218 A 282.0 260.0 12 29 17 12 [[422, 678]] 1.0 6yr9 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9B Q05397 414 684 1052.0 P9K:701 Type1 Inactive DFGin 6.5412 15.688 None -72.19, -175.35 -58.86, 135.81 -72.29, -35.25 299.46, 167.83 -65.13, -41.68 in-in in 7.4869 Saltbr-in 2.81 HRD-in -74.4, -54.18 84.68, -14.66 in-out-out SNCioo out-out ActLoopNT-out 10.6014 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -51.93 APE9-dihe-in -104.69, 112.5 APE8-dihe-in -81.62, 64.47 APE8-rot-na 30.93 APE67-dihe-in -65.67, -8.67 -53.83, -41.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.4458 APE9-dist-out 8.9872 None None None XRAY 1.925 0.193 0.218 B 282.0 258.0 13 29 16 13 [[422, 678]] 1.0 6yr9 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9C Q05397 414 686 1052.0 P9K:701 Type1 Inactive DFGin 6.7066 15.6963 None -74.62, -175.14 -58.39, 136.31 -73.32, -36.06 298.17, 169.43 -64.54, -38.88 in-in in 7.4756 Saltbr-in 2.8023 HRD-in -67.84, -54.81 84.4, -10.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.96 APE8-dihe-in -83.91, 65.47 APE8-rot-na 32.43 APE67-dihe-in -66.56, -9.09 -55.03, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5794 None None None XRAY 1.925 0.193 0.218 C 282.0 258.0 15 29 14 15 [[422, 678]] 1.0 6yr9 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9D Q05397 412 685 1052.0 P9K:701 Type1 Inactive DFGin 6.8495 15.8997 None -73.97, -177.5 -59.32, 135.48 -74.09, -34.16 299.25, 167.14 -64.12, -40.48 in-in in 7.4832 Saltbr-in 2.8033 HRD-in -67.32, -56.9 82.13, -9.82 in-out-out SNCioo out-out ActLoopNT-out 11.9249 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.57 APE8-dihe-in -85.42, 67.52 APE8-rot-na 30.81 APE67-dihe-in -67.68, -8.19 -56.08, -39.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5104 None None None XRAY 1.925 0.193 0.218 D 282.0 262.0 12 29 17 12 [[422, 678]] 1.0 6yr9 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVSB Q05397 415 686 1052.0 PVT:701 Type1 Inactive DFGin 6.5709 16.0404 None -126.79, -3.83 -122.97, 123.34 -125.84, 999.0 281.41, 69.18 999.0, 999.0 in-in in 7.981 Saltbr-in 2.8944 HRD-in -66.74, -51.12 77.94, -4.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.44 APE8-dihe-in -83.24, 64.15 APE8-rot-na 28.78 APE67-dihe-in -64.0, -16.76 -48.41, -44.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1895 None None None XRAY 1.81 0.193 0.215 B 282.0 254.0 18 29 11 18 [[422, 678]] 1.0 6yvs TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVSD Q05397 412 686 1052.0 PVT:701 Type1 Inactive DFGin 7.1321 16.183 None -76.03, -175.56 -60.31, 138.69 -87.68, 999.0 305.08, 167.36 999.0, 999.0 in-in in 7.4899 Saltbr-in 2.7592 HRD-in -66.73, -51.22 77.37, -3.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.69 APE8-dihe-in -83.36, 63.72 APE8-rot-na 28.67 APE67-dihe-in -66.21, -12.54 -49.68, -44.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2983 None None None XRAY 1.81 0.193 0.215 D 282.0 257.0 18 29 11 18 [[422, 678]] 1.0 6yvs TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVYC Q05397 411 686 1052.0 P1E:802 Type1 Inactive DFGin 6.9905 16.3619 None -69.66, 178.7 -62.98, 133.91 -77.95, 999.0 300.74, 174.12 999.0, 999.0 in-in in 7.5264 Saltbr-in 2.7334 HRD-in -68.55, -50.55 78.07, -8.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.77 APE8-dihe-in -81.84, 60.78 APE8-rot-na 33.33 APE67-dihe-in -67.16, -11.03 -46.06, -44.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1877 None None None XRAY 1.918 0.215 0.235 C 282.0 258.0 18 29 11 18 [[422, 678]] 1.0 6yvy TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVYD Q05397 415 686 1052.0 P1E:701 Type1 Inactive DFGin 7.055 14.8699 None -121.81, -169.66 55.51, 105.08 -131.24, 999.0 291.45, 85.32 999.0, 999.0 in-out in 7.9916 Saltbr-out 4.5329 HRD-in -68.69, -50.74 77.4, -7.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 145.59 APE9-dihe-in -72.33, 140.74 APE8-dihe-in -81.37, 62.58 APE8-rot-na 30.99 APE67-dihe-in -64.82, -12.74 -48.02, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3029 None None None XRAY 1.918 0.215 0.235 D 282.0 255.0 17 29 12 17 [[422, 678]] 1.0 6yvy TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVA Q05397 414 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.7802 15.896 None -74.38, 172.96 -50.5, 132.87 -70.58, -33.64 295.92, 176.86 -68.7, -41.79 in-in in 7.5061 Saltbr-in 2.7399 HRD-in -63.96, -44.94 72.24, 2.92 in-out-out SNCioo out-out ActLoopNT-out 11.9579 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.63 APE8-dihe-in -85.47, 62.62 APE8-rot-na 31.57 APE67-dihe-in -70.39, -3.07 -47.35, -41.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2994 None None None XRAY 2.298 0.203 0.232 A 282.0 261.0 12 29 17 12 [[422, 678]] 1.0 6yxv TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVB Q05397 415 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.7497 15.9158 None -75.08, 173.66 -51.87, 131.63 -68.87, -32.97 295.29, 177.69 -68.78, -48.08 in-in in 7.6569 Saltbr-in 2.7407 HRD-in -62.92, -46.64 75.37, -2.33 in-out-out SNCioo out-out ActLoopNT-out 11.9776 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.82 APE8-dihe-in -86.78, 62.62 APE8-rot-na 30.42 APE67-dihe-in -70.82, -2.85 -47.09, -41.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.187 None None None XRAY 2.298 0.203 0.232 B 282.0 260.0 12 29 17 12 [[422, 678]] 1.0 6yxv TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVC Q05397 414 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.8997 16.0318 None -74.5, 172.75 -51.5, 132.3 -71.72, -29.34 296.05, 175.78 -71.46, -48.84 in-in in 7.5013 Saltbr-in 2.7429 HRD-in -62.86, -46.42 73.82, -1.43 in-out-out SNCioo out-out ActLoopNT-out 12.0766 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -77.88, 152.47 APE9-dihe-in -135.02, 147.01 APE8-dihe-in -86.57, 63.93 APE8-rot-na 30.34 APE67-dihe-in -70.64, -1.8 -47.53, -42.32 APE12-dist-na 999.0 APE11-dist-na 16.304 APE10-dist-na 14.5361 APE9-dist-out 8.2347 None None None XRAY 2.298 0.203 0.232 C 282.0 265.0 8 29 21 8 [[422, 678]] 1.0 6yxv TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVD Q05397 415 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.5466 15.9097 None -69.88, 170.62 -49.04, 129.98 -64.73, -39.06 297.56, 170.69 -61.08, -44.2 in-in in 7.6236 Saltbr-in 2.7725 HRD-in -62.37, -45.76 74.99, -1.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.03 APE8-dihe-in -85.67, 62.63 APE8-rot-na 30.22 APE67-dihe-in -70.22, -2.35 -46.36, -42.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3226 None None None XRAY 2.298 0.203 0.232 D 282.0 257.0 15 29 14 15 [[422, 678]] 1.0 6yxv TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2B FAK2_HUMAN 3FZOA Q14289 420 691 1009.0 No_ligand No_ligand Inactive DFGin 7.0411 16.6484 None -80.41, -161.53 -55.79, 145.03 -57.19, 149.81 278.1, 79.23 -63.36, 124.08 in-out in 8.6788 Saltbr-out 3.9901 HRD-in -88.56, -44.48 71.73, -1.23 out-out-out SNCooo out-out ActLoopNT-out 7.2159 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.21 APE8-dihe-in -78.85, 65.44 APE8-rot-na 30.29 APE67-dihe-in -67.97, -12.51 -51.67, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2021 None None None XRAY 2.2 0.207 0.265 A 277.0 262.0 10 29 19 10 [[425, 681]] 1.0 3fzo TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 8YGXA Q14289 420 691 1009.0 No_ligand No_ligand Inactive DFGin 7.3395 16.9549 None -81.04, -163.09 -79.3, 167.03 -64.4, 154.66 279.14, 72.36 -77.31, 999.0 in-out in 9.6398 Saltbr-out 9.5712 HRD-in -87.71, -52.71 73.64, 6.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 156.88 APE8-dihe-in -79.69, 73.24 APE8-rot-na 32.8 APE67-dihe-in -69.65, -12.51 -56.52, -42.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1124 None None None XRAY 2.0 0.209 0.27 A 277.0 255.0 17 29 12 17 [[425, 681]] 1.0 8ygx TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 3CC6A Q14289 415 692 1009.0 No_ligand No_ligand Inactive DFGin 7.0032 16.5591 None -87.76, -163.7 -58.23, 148.28 -56.0, 147.59 284.53, 73.73 -57.12, 131.04 in-in in 8.8937 Saltbr-in 3.5112 HRD-in -90.62, -51.5 76.85, -2.02 in-out-out SNCioo out-out ActLoopNT-out 7.4363 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 61.77, 49.9 APE9-dihe-in -65.83, 147.14 APE8-dihe-in -78.84, 67.36 APE8-rot-na 28.85 APE67-dihe-in -70.52, -9.23 -47.7, -42.04 APE12-dist-na 14.4486 APE11-dist-na 8.5486 APE10-dist-na 10.5072 APE9-dist-out 8.2152 None None None XRAY 1.6 0.187 0.219 A 281.0 269.0 9 29 20 9 [[425, 681]] 1.0 3cc6 TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 8XOXA Q14289 417 692 1009.0 YAM:701 Type1 Inactive DFGin 6.9505 16.4086 None -80.09, -162.96 -67.92, 153.8 -59.81, 149.69 281.78, 71.56 -67.49, 135.35 in-out in 9.5056 Saltbr-out 8.7294 HRD-in -84.67, -50.29 73.68, 0.48 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.93 APE8-dihe-in -79.37, 59.37 APE8-rot-na 36.03 APE67-dihe-in -77.94, -4.55 -50.42, -39.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3588 None None None XRAY 1.9 0.172 0.23 A 277.0 261.0 15 29 14 15 [[425, 681]] 1.0 8xox TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 5TOBA Q14289 420 690 1009.0 YAM:701 Type1 Inactive DFGin 6.6239 15.8925 None -80.12, -169.51 -62.87, 163.32 -68.81, 156.27 288.67, 73.8 -89.77, 999.0 in-none in 9.4038 Saltbr-none 999.0 HRD-in -91.14, -46.46 78.7, -8.23 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 58.94 APE8-rot-na 29.17 APE67-dihe-in -80.81, -3.79 -54.7, -37.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.117 0.212 0.262 A 282.0 245.0 26 29 11 18 [[425, 681]] 1.0 5tob TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR ROS1 ROS1_HUMAN 7Z5WA P08922 1937 2225 2347.0 IDW:2301 Type1 Inactive DFGin 6.695 14.3208 None -94.7, -152.87 -20.72, 134.4 -104.55, 141.7 300.47, 74.83 -69.24, 999.0 in-out in 7.9518 Saltbr-out 4.6104 HRD-in -58.16, -44.63 77.6, -17.37 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.24 APE8-dihe-in -84.74, 70.79 APE8-rot-na 30.54 APE67-dihe-in -61.34, -19.9 -51.55, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5582 None None None XRAY 2.254 0.226 0.276 A 331.0 271.0 18 30 12 18 [[1945, 2217]] 1.0 7z5w TYR_ROS1_HUMAN TYR 6e-95 323.4 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5WB P08922 1937 2226 2347.0 IDW:2301 Type1 Inactive DFGin 6.8361 14.2683 None -118.79, -153.42 52.77, -75.92 69.95, 35.45 304.69, 93.82 -135.83, 999.0 in-out in 7.9597 Saltbr-out 5.1038 HRD-in -71.29, -42.41 71.74, -4.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.77 APE8-dihe-in -83.18, 59.59 APE8-rot-na 31.32 APE67-dihe-in -66.39, -14.66 -46.18, -41.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8303 None None None XRAY 2.254 0.226 0.276 B 331.0 272.0 18 30 12 18 [[1945, 2217]] 1.0 7z5w TYR_ROS1_HUMAN TYR 6e-95 323.4 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5XA P08922 1937 2225 2347.0 AWJ:2301 Type1 Inactive DFGin 7.1398 14.3259 None -115.65, -151.87 19.28, 91.72 -103.73, 999.0 300.69, 79.11 999.0, 999.0 in-in in 7.8876 Saltbr-in 3.0105 HRD-in -78.13, -45.97 75.44, -15.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.49 APE8-dihe-in -89.41, 63.11 APE8-rot-na 11.43 APE67-dihe-in -63.61, -20.18 -48.49, -41.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6377 None None None XRAY 2.035 0.229 0.266 A 331.0 270.0 19 30 11 19 [[1945, 2217]] 1.0 7z5x TYR_ROS1_HUMAN TYR 6e-95 323.4 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5XB P08922 1937 2226 2347.0 AWJ:2301 Type1 Inactive DFGin 7.1504 14.3759 None -105.58, -155.45 22.98, 111.73 -123.72, 999.0 298.95, 81.3 999.0, 999.0 in-in in 7.8715 Saltbr-in 3.0051 HRD-in -72.3, -46.74 74.95, -14.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.07 APE8-dihe-in -86.07, 63.61 APE8-rot-na 10.54 APE67-dihe-in -63.94, -20.45 -49.44, -39.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6733 None None None XRAY 2.035 0.229 0.266 B 331.0 271.0 19 30 11 19 [[1945, 2217]] 1.0 7z5x TYR_ROS1_HUMAN TYR 6e-95 323.4 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 9QEKA P08922 1934 2229 2347.0 A1I6Z:62302 Type1 Inactive DFGin 6.4192 14.2358 None -128.5, -154.51 48.35, 74.6 -100.28, 999.0 297.06, 101.75 999.0, 999.0 in-out in 7.9577 Saltbr-out 4.5376 HRD-in -77.5, -45.64 72.03, 12.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 125.32 APE9-dihe-in -104.47, 106.45 APE8-dihe-in -80.98, 70.72 APE8-rot-na 35.17 APE67-dihe-in -71.98, -20.47 -66.89, -32.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3264 G2032R None None XRAY 2.205 0.203 0.272 A 301.0 274.0 22 30 12 18 [[1945, 2217]] 1.0 9qek TYR_ROS1_HUMAN TYR 2.3e-93 318.2 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR RYK RYK_HUMAN 6TUAA P34925 298 607 607.0 No_ligand No_ligand Inactive DFGin 10.422 12.8169 None -111.35, 168.38 -65.12, 162.3 -99.64, 13.64 76.36, 144.56 -58.39, 128.02 in-out in 9.6672 Saltbr-out 7.7988 HRD-in -75.74, -45.14 73.26, -4.48 out-out-in SNCooi out-in ActLoopNT-out 15.1476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.79, 98.06 APE9-dihe-in -120.22, 150.53 APE8-dihe-in -77.84, 63.77 APE8-rot-na 29.73 APE67-dihe-in -74.25, -12.88 -52.81, -38.05 APE12-dist-na 999.0 APE11-dist-na 15.6489 APE10-dist-na 11.4308 APE9-dist-in 7.5421 None None None XRAY 2.38 0.197 0.248 A 317.0 294.0 9 30 27 3 [[330, 598]] 1.0 6tua TYR_RYK_HUMAN TYR 9.9e-80 273.5 1.0 260.0 260.0 482 483 484 486 488 364 381 385 462 464 463 465.0 524 512 507 506 505 504 503 502 501 412 Tyrosine-protein kinase RYK
TYR SRC SRC_HUMAN 8HAQA P12931 260 536 536.0 L1N:60601 Type1 Inactive DFGin 7.4752 16.4948 None -144.71, -178.06 51.15, 59.96 -68.83, 999.0 277.81, 75.52 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -79.23, -51.06 84.94, -13.72 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.15 APE8-rot-na 32.35 APE67-dihe-in -66.25, -16.22 -57.53, -32.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.209 0.25 A 277.0 247.0 30 29 10 19 [[270, 521]] 1.0 8haq TYR_SRC_HUMAN TYR 1.4e-94 322.1 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 8JF3B P12931 261 536 536.0 C0N:601 Type1 Inactive DFGin 7.1348 16.0627 None -135.82, -168.85 67.82, -93.47 69.27, 999.0 290.66, 103.97 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -92.02, -35.42 67.06, 3.83 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.11 APE8-rot-na 10.82 APE67-dihe-in -68.72, -22.89 -67.01, -25.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.846 0.278 0.317 B 283.0 238.0 38 29 10 19 [[270, 521]] 1.0 8jf3 TYR_SRC_HUMAN TYR 1.5e-94 322.0 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 1YOMB P12931 258 536 536.0 P01:60002 Type1 Inactive DFGin 7.1447 15.9556 None -150.45, -153.06 39.29, 44.85 -55.46, 999.0 262.87, 79.79 999.0, 999.0 in-none in 7.3529 Saltbr-none 999.0 HRD-in -98.52, -48.38 85.73, -24.58 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.01 APE8-dihe-out -94.51, 44.94 APE8-rot-na 35.15 APE67-dihe-in -62.96, -31.73 -55.8, -34.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5153 S345N,A370S,Y419W None None XRAY 2.9 0.222 0.313 B 283.0 261.0 18 29 11 18 [[270, 521]] 1.0 1yom TYR_SRC_HUMAN TYR 1.9e-93 318.4 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR TNK2 ACK1_HUMAN 8HMTD Q07912 117 389 1038.0 LWX:401 Type1.5_Back Inactive DFGin 6.3063 13.3328 None -101.89, -122.34 -52.57, 148.88 -124.51, 20.24 302.36, 99.89 -60.05, -38.85 in-out in 8.5635 Saltbr-out 3.702 HRD-in -85.57, -47.32 68.53, 3.51 out-in-in SNCoii in-in ActLoopNT-in 3.0608 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.15, 128.97 APE9-dihe-in -122.52, 150.9 APE8-dihe-in -68.07, 94.15 APE8-rot-na 328.13 APE67-dihe-in -58.59, -46.12 -66.12, -27.69 APE12-dist-na 12.502 APE11-dist-na 7.8076 APE10-dist-na 10.8535 APE9-dist-in 5.8558 None None None XRAY 3.17 0.209 0.264 D 273.0 262.0 11 31 31 0 [[126, 387]] 1.0 8hmt TYR_TNK2_HUMAN TYR 7.1e-86 293.6 1.0 259.0 259.0 269 270 271 273 275 158 177 181 249 251 250 252.0 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
TYR TYK2-1 TYK2_HUMAN 5C03A P29597 579 869 1187.0 AGS:901 ATPlike Pseudo DFGin 7.3841 13.1047 None -83.93, 173.19 -65.21, 161.12 -79.17, -4.85 20.2, 153.73 66.68, -148.85 in-na in 9.7941 Saltbr-na 999.0 HRD-in -90.34, -65.69 85.25, 3.79 na-out-out SNCaoo out-out ActLoopNT-out 7.8327 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.44, -38.84 APE9-dihe-out -63.06, -21.54 APE8-dihe-out -87.7, -1.06 APE8-rot-na 196.81 APE67-dihe-out -97.84, 8.94 -69.26, 133.75 APE12-dist-na 10.117 APE11-dist-na 12.2506 APE10-dist-na 16.4571 APE9-dist-out 11.202 None None None XRAY 1.9 0.183 0.218 A 342.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 5c03 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C03B P29597 580 870 1187.0 AGS:901 ATPlike Pseudo DFGin 7.5169 12.8858 None -71.74, 164.11 -66.43, 161.04 -81.86, 0.59 24.73, 148.49 67.14, -147.92 in-na in 9.7089 Saltbr-na 999.0 HRD-in -90.78, -63.58 88.98, 2.52 na-out-out SNCaoo out-out ActLoopNT-out 7.9567 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.24, -42.55 APE9-dihe-out -56.38, -27.94 APE8-dihe-out -85.13, -4.16 APE8-rot-na 194.3 APE67-dihe-out -97.21, 10.32 -66.64, 134.88 APE12-dist-na 9.6347 APE11-dist-na 12.3036 APE10-dist-na 16.4844 APE9-dist-out 11.2214 None None None XRAY 1.9 0.183 0.218 B 342.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 5c03 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4A P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.5069 12.8047 None -76.81, 166.44 -58.43, 152.23 -70.05, -8.8 24.77, 146.14 76.34, -154.15 in-na in 9.5557 Saltbr-na 999.0 HRD-in -86.69, -61.89 82.12, 4.68 na-out-out SNCaoo out-out ActLoopNT-out 8.2321 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.65, -45.17 APE9-dihe-out -58.59, -27.02 APE8-dihe-out -78.56, -9.63 APE8-rot-na 222.71 APE67-dihe-out -95.98, 6.87 -68.07, 131.63 APE12-dist-na 9.6622 APE11-dist-na 12.2836 APE10-dist-na 16.4637 APE9-dist-out 11.658 None None None XRAY 2.12 0.186 0.229 A 295.0 261.0 29 24 24 0 [[589, 868], [897, 1171]] 2.0 7ax4 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4B P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.4876 12.7756 None -74.88, 165.0 -57.44, 152.12 -71.28, -8.27 25.03, 145.7 75.91, -154.77 in-na in 9.4964 Saltbr-na 999.0 HRD-in -85.26, -61.54 83.16, 3.63 na-out-out SNCaoo out-out ActLoopNT-out 8.3251 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.51, -41.43 APE9-dihe-out -63.74, -26.18 APE8-dihe-out -77.76, -6.82 APE8-rot-na 221.04 APE67-dihe-out -90.97, 8.23 -71.21, 136.1 APE12-dist-na 9.8072 APE11-dist-na 12.3205 APE10-dist-na 16.5418 APE9-dist-out 11.7928 None None None XRAY 2.12 0.186 0.229 B 295.0 261.0 29 24 24 0 [[589, 868], [897, 1171]] 2.0 7ax4 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98A P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.3534 12.6977 None -63.41, 150.46 -40.02, 136.95 -69.11, -5.37 28.88, 139.25 79.24, -154.61 in-na in 9.6761 Saltbr-na 999.0 HRD-in -86.71, -58.07 85.92, 3.99 na-out-out SNCaoo out-out ActLoopNT-out 8.1152 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.34, -41.36 APE9-dihe-out -63.27, -26.83 APE8-dihe-out -87.06, 1.76 APE8-rot-na 289.42 APE67-dihe-out -101.27, 10.15 -70.05, 135.5 APE12-dist-na 9.7695 APE11-dist-na 12.3681 APE10-dist-na 16.5009 APE9-dist-out 11.6332 None None CSO808 XRAY 1.87 0.226 0.274 A 295.0 256.0 35 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98B P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.3388 12.942 None -54.77, 156.29 -53.9, 146.74 -74.48, -2.14 30.11, 138.2 66.75, -149.92 in-na in 9.6961 Saltbr-na 999.0 HRD-in -77.0, -58.39 85.56, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.4655 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.92, -37.3 APE9-dihe-out -60.59, -30.35 APE8-dihe-out -84.45, -1.45 APE8-rot-na 293.47 APE67-dihe-out -99.24, 10.29 -63.77, 131.59 APE12-dist-na 9.9673 APE11-dist-na 12.261 APE10-dist-na 16.5394 APE9-dist-out 11.7384 None None CSO808 XRAY 1.87 0.226 0.274 B 295.0 259.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98C P29597 578 868 1187.0 ZRU:901 Type1 Pseudo DFGin 7.5577 12.8193 None -59.14, 154.57 -51.18, 142.9 -77.73, 6.11 31.51, 139.73 67.49, -158.75 in-na in 9.6147 Saltbr-na 999.0 HRD-in -81.52, -60.95 90.44, 9.6 na-out-out SNCaoo out-out ActLoopNT-out 8.5721 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.87, -38.56 APE9-dihe-out -63.68, -27.1 APE8-dihe-out -84.04, -1.3 APE8-rot-na 288.57 APE67-dihe-out -98.82, 11.75 -65.96, 135.63 APE12-dist-na 9.9318 APE11-dist-na 12.2766 APE10-dist-na 16.5124 APE9-dist-out 11.8618 None None CSO808 XRAY 1.87 0.226 0.274 C 295.0 261.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99A P29597 578 868 1187.0 ZS3:901 Type1 Pseudo DFGin 7.3994 12.7822 None -62.82, 155.3 -51.38, 147.9 -74.24, -0.55 28.63, 142.53 65.17, -151.12 in-na in 9.6586 Saltbr-na 999.0 HRD-in -82.17, -60.98 83.64, 7.23 na-out-out SNCaoo out-out ActLoopNT-out 8.3299 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -38.21 APE9-dihe-out -59.13, -29.8 APE8-dihe-out -88.76, 1.4 APE8-rot-na 298.32 APE67-dihe-out -97.29, 12.8 -68.06, 135.28 APE12-dist-na 9.9277 APE11-dist-na 12.29 APE10-dist-na 16.5863 APE9-dist-out 11.7615 None None None XRAY 1.71 0.191 0.225 A 295.0 261.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99B P29597 579 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.4426 12.6145 None -56.5, 153.96 -51.89, 147.7 -74.35, -1.31 29.46, 140.64 65.58, -151.37 in-na in 9.5567 Saltbr-na 999.0 HRD-in -80.48, -58.61 84.39, 4.19 na-out-out SNCaoo out-out ActLoopNT-out 8.4257 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.04, -40.63 APE9-dihe-out -58.98, -25.02 APE8-dihe-out -89.21, 1.32 APE8-rot-na 294.34 APE67-dihe-out -101.31, 17.67 -66.15, 136.61 APE12-dist-na 9.9093 APE11-dist-na 12.1858 APE10-dist-na 16.4711 APE9-dist-out 11.849 None None None XRAY 1.71 0.191 0.225 B 295.0 261.0 29 24 24 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99C P29597 578 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.4621 12.589 None -61.71, 157.01 -52.78, 147.81 -73.85, -0.24 30.37, 137.25 70.68, -153.5 in-na in 9.5877 Saltbr-na 999.0 HRD-in -82.08, -63.18 88.21, 6.86 na-out-out SNCaoo out-out ActLoopNT-out 8.1733 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.66, -43.16 APE9-dihe-out -54.27, -29.75 APE8-dihe-out -91.84, 3.24 APE8-rot-na 295.26 APE67-dihe-out -102.57, 13.29 -66.4, 134.15 APE12-dist-na 9.7375 APE11-dist-na 12.4322 APE10-dist-na 16.5442 APE9-dist-out 11.6845 None None None XRAY 1.71 0.191 0.225 C 295.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AA P29597 577 868 1187.0 ZSB:901 Type1 Pseudo DFGin 7.4645 12.7833 None -59.49, 156.87 -53.44, 145.49 -73.94, -3.93 28.08, 142.08 71.29, -152.49 in-na in 9.6449 Saltbr-na 999.0 HRD-in -80.97, -57.69 81.03, 6.24 na-out-out SNCaoo out-out ActLoopNT-out 8.4683 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.12, -39.62 APE9-dihe-out -57.45, -31.53 APE8-dihe-out -85.9, -0.44 APE8-rot-na 294.43 APE67-dihe-out -98.22, 12.4 -65.02, 133.34 APE12-dist-na 9.9666 APE11-dist-na 12.2854 APE10-dist-na 16.6055 APE9-dist-out 11.8385 None None None XRAY 1.83 0.186 0.224 A 295.0 264.0 28 24 24 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AB P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.5488 12.6065 None -55.02, 155.39 -55.48, 149.15 -78.11, 1.0 33.17, 138.7 68.16, -152.66 in-na in 9.568 Saltbr-na 999.0 HRD-in -83.23, -60.75 91.28, -0.48 na-out-out SNCaoo out-out ActLoopNT-out 8.591 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.5, -42.74 APE9-dihe-out -57.15, -27.18 APE8-dihe-out -83.95, -1.9 APE8-rot-na 289.14 APE67-dihe-out -98.17, 15.26 -66.86, 137.45 APE12-dist-na 9.96 APE11-dist-na 12.0778 APE10-dist-na 16.4122 APE9-dist-out 11.8945 None None None XRAY 1.83 0.186 0.224 B 295.0 263.0 28 24 24 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AC P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.4518 12.6679 None -61.15, 155.8 -50.19, 148.71 -74.89, -0.44 30.12, 140.82 66.87, -150.05 in-na in 9.6545 Saltbr-na 999.0 HRD-in -81.68, -62.05 88.29, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.2603 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.23, -43.49 APE9-dihe-out -60.0, -25.56 APE8-dihe-out -89.19, -0.15 APE8-rot-na 289.26 APE67-dihe-out -98.71, 15.21 -67.33, 135.82 APE12-dist-na 9.6965 APE11-dist-na 12.3095 APE10-dist-na 16.4937 APE9-dist-out 11.7664 None None None XRAY 1.83 0.186 0.224 C 295.0 261.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDA P29597 581 866 1187.0 7GL:901 Type1 Pseudo DFGin 7.5132 12.6298 None -67.32, 165.44 -61.21, 150.11 -77.85, 2.5 30.62, 144.39 70.23, -152.17 in-na in 9.487 Saltbr-na 999.0 HRD-in -86.12, -60.06 82.4, 7.11 na-out-out SNCaoo out-out ActLoopNT-out 8.1629 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.41, -39.74 APE9-dihe-out -61.67, -21.18 APE8-dihe-out -86.78, -7.05 APE8-rot-na 289.65 APE67-dihe-out -93.06, 5.59 -69.25, 133.26 APE12-dist-na 9.6904 APE11-dist-na 12.2198 APE10-dist-na 16.4057 APE9-dist-out 11.5781 None None None XRAY 1.92 0.193 0.215 A 298.0 248.0 40 24 24 0 [[589, 868], [897, 1171]] 2.0 5tkd TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDB P29597 581 867 1187.0 7GL:901 Type1 Pseudo DFGin 7.5338 12.4894 None -66.93, 165.19 -61.5, 149.63 -77.96, 1.32 30.48, 144.44 72.41, -154.16 in-na in 9.4218 Saltbr-na 999.0 HRD-in -86.72, -59.64 79.99, 10.31 na-out-out SNCaoo out-out ActLoopNT-out 8.0292 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.45, -40.77 APE9-dihe-out -60.64, -23.02 APE8-dihe-out -86.44, -3.61 APE8-rot-na 200.95 APE67-dihe-out -92.39, 6.26 -73.47, 133.63 APE12-dist-na 9.6657 APE11-dist-na 12.184 APE10-dist-na 16.3806 APE9-dist-out 11.4573 None None None XRAY 1.92 0.193 0.215 B 298.0 247.0 41 24 24 0 [[589, 868], [897, 1171]] 2.0 5tkd TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 3ZONA P29597 577 870 1187.0 IK1:1871 Type1 Pseudo DFGin 7.3684 12.7622 None -83.03, 173.2 -63.77, 153.55 -76.54, -5.77 26.47, 146.49 67.78, -154.99 in-na in 9.6551 Saltbr-na 999.0 HRD-in -77.23, -57.87 87.41, -1.46 na-out-out SNCaoo out-out ActLoopNT-out 8.3603 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.01, -48.69 APE9-dihe-out -50.14, -31.16 APE8-dihe-out -81.83, -2.56 APE8-rot-na 292.76 APE67-dihe-out -91.8, 2.07 -66.27, 133.13 APE12-dist-na 10.153 APE11-dist-na 12.3104 APE10-dist-na 16.6205 APE9-dist-out 11.9768 None None None XRAY 2.15 0.217 0.268 A 335.0 261.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 3zon TYR_TYK2-1_HUMAN TYR 6.5e-60 208.7 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRA P29597 578 867 1187.0 LAJ:901 Type1 Pseudo DFGin 7.7767 12.7807 None -69.45, 168.07 -65.99, 154.27 -73.6, -4.41 23.84, 151.16 77.17, -140.45 in-na in 9.4351 Saltbr-na 999.0 HRD-in -82.75, -62.0 89.42, -4.52 na-out-out SNCaoo out-out ActLoopNT-out 8.0946 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.36, -40.74 APE9-dihe-out -63.5, -26.3 APE8-dihe-out -83.27, -1.28 APE8-rot-na 205.99 APE67-dihe-out -86.49, -0.68 -74.39, 134.15 APE12-dist-na 9.7117 APE11-dist-na 12.1953 APE10-dist-na 16.3588 APE9-dist-out 11.5527 None None None XRAY 2.56 0.19 0.229 A 317.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzr TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRB P29597 580 868 1187.0 LAJ:901 Type1 Pseudo DFGin 7.7942 12.7348 None -69.51, 167.49 -66.18, 155.4 -74.3, -4.56 23.99, 151.21 77.6, -139.58 in-na in 9.3707 Saltbr-na 999.0 HRD-in -85.74, -61.72 89.77, -6.44 na-out-out SNCaoo out-out ActLoopNT-out 8.1637 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.72, -41.32 APE9-dihe-out -63.03, -22.95 APE8-dihe-out -84.92, -4.81 APE8-rot-na 227.24 APE67-dihe-out -86.54, 0.37 -71.84, 134.55 APE12-dist-na 9.7055 APE11-dist-na 12.2225 APE10-dist-na 16.3775 APE9-dist-out 11.5502 None None None XRAY 2.56 0.19 0.229 B 317.0 259.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzr TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVA P29597 580 869 1187.0 3SM:901 Type1 Pseudo DFGin 7.414 12.6121 None -81.79, 172.74 -64.96, 152.2 -79.14, 3.8 29.41, 144.45 64.39, -148.74 in-na in 9.4339 Saltbr-na 999.0 HRD-in -91.37, -57.71 81.66, 1.38 na-out-out SNCaoo out-out ActLoopNT-out 8.4716 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.89, -40.33 APE9-dihe-out -59.96, -25.88 APE8-dihe-out -82.28, -6.26 APE8-rot-na 203.31 APE67-dihe-out -93.77, 1.64 -65.5, 131.41 APE12-dist-na 9.8652 APE11-dist-na 12.1551 APE10-dist-na 16.3727 APE9-dist-out 11.6198 None None None XRAY 1.8 0.193 0.214 A 317.0 258.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 4wov TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVB P29597 580 867 1187.0 3SM:901 Type1 Pseudo DFGin 7.3745 12.5637 None -82.96, 174.29 -64.97, 150.22 -78.54, 4.38 29.82, 144.02 64.16, -150.45 in-na in 9.3856 Saltbr-na 999.0 HRD-in -91.0, -57.11 81.71, 1.86 na-out-out SNCaoo out-out ActLoopNT-out 8.5397 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.69, -39.07 APE9-dihe-out -62.22, -22.21 APE8-dihe-out -86.45, -3.31 APE8-rot-na 190.55 APE67-dihe-out -96.7, 6.38 -71.04, 134.12 APE12-dist-na 9.8281 APE11-dist-na 12.1118 APE10-dist-na 16.3132 APE9-dist-out 11.6558 None None None XRAY 1.8 0.193 0.214 B 317.0 256.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 4wov TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLA P29597 581 866 1187.0 KZJ:901 Type1 Pseudo DFGin 7.4466 12.6266 None -65.67, 163.1 -59.9, 147.3 -72.43, 0.95 25.4, 149.24 71.0, -150.31 in-na in 9.4495 Saltbr-na 999.0 HRD-in -79.19, -61.15 86.61, -0.76 na-out-out SNCaoo out-out ActLoopNT-out 8.317 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.34, -39.28 APE9-dihe-out -63.02, -22.39 APE8-dihe-out -82.22, -10.35 APE8-rot-na 292.93 APE67-dihe-out -91.53, -2.04 -67.32, 133.05 APE12-dist-na 9.7215 APE11-dist-na 12.197 APE10-dist-na 16.4126 APE9-dist-out 11.6997 None None None XRAY 2.15 0.203 0.213 A 317.0 251.0 37 24 24 0 [[589, 868], [897, 1171]] 2.0 6nsl TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLB P29597 581 867 1187.0 KZJ:901 Type1 Pseudo DFGin 7.4662 12.5425 None -65.53, 162.68 -58.2, 146.74 -72.38, 1.37 25.74, 148.82 71.06, -152.3 in-na in 9.4228 Saltbr-na 999.0 HRD-in -80.39, -61.97 87.32, -2.61 na-out-out SNCaoo out-out ActLoopNT-out 8.2412 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.57, -38.38 APE9-dihe-out -63.64, -23.52 APE8-dihe-out -84.88, -4.11 APE8-rot-na 200.51 APE67-dihe-out -91.36, -1.36 -71.83, 133.14 APE12-dist-na 9.6668 APE11-dist-na 12.1774 APE10-dist-na 16.3911 APE9-dist-out 11.5683 None None None XRAY 2.15 0.203 0.213 B 317.0 248.0 40 24 24 0 [[589, 868], [897, 1171]] 2.0 6nsl TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEA P29597 581 863 1187.0 L8Y:901 Type1 Pseudo DFGin 7.5169 12.3274 None -67.15, 165.53 -62.27, 154.27 -78.2, -0.61 28.22, 144.21 70.11, -150.04 in-na in 9.308 Saltbr-na 999.0 HRD-in -90.68, -61.1 81.57, 5.39 na-out-out SNCaoo out-out ActLoopNT-out 8.1267 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.25, -36.4 APE9-dihe-out -64.18, -24.4 APE8-dihe-out -85.3, -4.22 APE8-rot-na 196.84 APE67-dihe-out -93.12, 7.25 -69.65, 135.35 APE12-dist-na 9.8139 APE11-dist-na 12.2409 APE10-dist-na 16.4577 APE9-dist-out 11.4388 None None None XRAY 1.96 0.197 0.227 A 317.0 250.0 38 24 24 0 [[589, 868], [897, 1171]] 2.0 6nze TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEB P29597 580 867 1187.0 L8Y:901 Type1 Pseudo DFGin 7.5096 12.3305 None -67.31, 165.25 -60.76, 154.35 -79.17, -0.55 28.55, 143.7 69.96, -145.72 in-na in 9.3364 Saltbr-na 999.0 HRD-in -88.53, -60.87 81.08, 6.03 na-out-out SNCaoo out-out ActLoopNT-out 8.0726 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.94, -35.62 APE9-dihe-out -64.8, -24.24 APE8-dihe-out -85.49, -3.91 APE8-rot-na 196.79 APE67-dihe-out -92.3, 6.8 -70.0, 135.83 APE12-dist-na 9.7323 APE11-dist-na 12.1508 APE10-dist-na 16.3803 APE9-dist-out 11.4163 None None None XRAY 1.96 0.197 0.227 B 317.0 254.0 35 24 24 0 [[589, 868], [897, 1171]] 2.0 6nze TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFA P29597 580 865 1187.0 L91:901 Type1 Pseudo DFGin 7.5997 12.6706 None -71.29, 168.26 -64.87, 155.03 -75.86, -3.47 25.03, 153.09 77.38, -149.91 in-na in 9.4012 Saltbr-na 999.0 HRD-in -80.34, -62.67 82.96, 5.24 na-out-out SNCaoo out-out ActLoopNT-out 8.0939 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.48, -39.01 APE9-dihe-out -62.83, -25.44 APE8-dihe-out -82.23, -7.85 APE8-rot-na 215.68 APE67-dihe-out -92.43, 5.04 -68.27, 132.64 APE12-dist-na 9.8083 APE11-dist-na 12.2624 APE10-dist-na 16.5169 APE9-dist-out 11.6235 None None None XRAY 2.39 0.205 0.231 A 317.0 247.0 42 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzf TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFB P29597 580 867 1187.0 L91:901 Type1 Pseudo DFGin 7.6703 12.5979 None -70.84, 168.4 -64.97, 153.82 -75.67, -2.7 25.33, 152.34 77.04, -149.81 in-na in 9.3721 Saltbr-na 999.0 HRD-in -81.43, -61.17 83.19, 3.8 na-out-out SNCaoo out-out ActLoopNT-out 8.1122 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.59, -38.89 APE9-dihe-out -62.81, -25.28 APE8-dihe-out -84.37, -2.23 APE8-rot-na 213.59 APE67-dihe-out -91.99, 5.73 -72.88, 133.85 APE12-dist-na 9.7519 APE11-dist-na 12.2295 APE10-dist-na 16.478 APE9-dist-out 11.5547 None None None XRAY 2.39 0.205 0.231 B 317.0 248.0 41 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzf TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHA P29597 581 866 1187.0 L9A:4000 Type1 Pseudo DFGin 7.4056 12.7716 None -62.74, 170.7 -72.48, 150.15 -70.83, -2.83 23.35, 152.01 73.55, -152.26 in-na in 9.497 Saltbr-na 999.0 HRD-in -83.24, -60.86 86.7, -4.43 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -35.12 APE9-dihe-out -65.62, -29.8 APE8-dihe-out -77.88, -5.55 APE8-rot-na 294.99 APE67-dihe-out -89.76, 4.67 -72.08, 133.72 APE12-dist-na 9.7747 APE11-dist-na 12.2293 APE10-dist-na 16.4702 APE9-dist-out 11.3169 None None None XRAY 2.73 0.193 0.215 A 317.0 249.0 39 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzh TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHB P29597 580 867 1187.0 L9A:4000 Type1 Pseudo DFGin 7.436 12.5992 None -60.73, 169.6 -71.23, 150.14 -70.46, -1.47 23.31, 151.91 71.77, -152.11 in-na in 9.3762 Saltbr-na 999.0 HRD-in -83.11, -60.28 86.79, -5.89 na-out-out SNCaoo out-out ActLoopNT-out 8.3079 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.38, -35.33 APE9-dihe-out -65.44, -29.63 APE8-dihe-out -78.49, -5.17 APE8-rot-na 295.66 APE67-dihe-out -89.42, 4.66 -71.76, 134.2 APE12-dist-na 9.7352 APE11-dist-na 12.2156 APE10-dist-na 16.4369 APE9-dist-out 11.2686 None None None XRAY 2.73 0.193 0.215 B 317.0 249.0 40 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzh TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPA P29597 580 869 1187.0 LB7:901 Type1 Pseudo DFGin 7.454 12.358 None -74.98, 168.42 -62.51, 146.95 -73.8, -0.03 29.8, 144.9 77.36, -162.45 in-na in 9.2156 Saltbr-na 999.0 HRD-in -77.18, -62.62 87.16, 3.67 na-out-out SNCaoo out-out ActLoopNT-out 8.3072 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.98, -44.81 APE9-dihe-out -54.69, -25.84 APE8-dihe-out -83.74, 2.24 APE8-rot-na 279.61 APE67-dihe-out -91.79, -3.26 -74.14, 129.81 APE12-dist-na 9.758 APE11-dist-na 11.986 APE10-dist-na 16.1538 APE9-dist-out 11.5549 None None None XRAY 2.35 0.191 0.238 A 317.0 259.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzp TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPB P29597 580 868 1187.0 LB7:901 Type1 Pseudo DFGin 7.4573 12.3775 None -74.39, 168.01 -61.52, 147.56 -74.66, 0.45 29.5, 145.4 75.25, -161.58 in-na in 9.2883 Saltbr-na 999.0 HRD-in -77.4, -62.3 87.31, 3.57 na-out-out SNCaoo out-out ActLoopNT-out 8.2471 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -56.49, -45.45 APE9-dihe-out -54.3, -24.89 APE8-dihe-out -83.35, -4.08 APE8-rot-na 280.62 APE67-dihe-out -91.28, -1.02 -71.12, 130.29 APE12-dist-na 9.7731 APE11-dist-na 12.02 APE10-dist-na 16.2103 APE9-dist-out 11.5561 None None None XRAY 2.35 0.191 0.238 B 317.0 260.0 29 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzp TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQA P29597 580 867 1187.0 LB4:4000 Type1 Pseudo DFGin 7.5041 12.4001 None -72.22, 171.6 -66.25, 148.31 -74.94, 3.34 30.76, 143.31 66.4, -168.53 in-na in 9.0385 Saltbr-na 999.0 HRD-in -79.47, -65.7 83.13, 11.6 na-out-out SNCaoo out-out ActLoopNT-out 8.4967 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.2, -35.07 APE9-dihe-out -63.1, -22.48 APE8-dihe-out -87.78, -5.31 APE8-rot-na 268.32 APE67-dihe-out -91.66, 0.19 -69.75, 131.87 APE12-dist-na 9.8813 APE11-dist-na 12.0917 APE10-dist-na 16.3683 APE9-dist-out 11.7203 None None None XRAY 2.11 0.199 0.237 A 317.0 256.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzq TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQB P29597 580 868 1187.0 LB4:4000 Type1 Pseudo DFGin 7.5519 12.3705 None -70.99, 170.41 -64.59, 148.83 -75.35, 4.18 30.96, 143.54 65.3, -166.93 in-na in 8.9581 Saltbr-na 999.0 HRD-in -80.49, -65.88 83.34, 10.69 na-out-out SNCaoo out-out ActLoopNT-out 8.4422 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.78, -35.63 APE9-dihe-out -62.43, -22.89 APE8-dihe-out -87.56, -5.29 APE8-rot-na 268.51 APE67-dihe-out -92.56, 0.73 -69.67, 131.53 APE12-dist-na 9.9105 APE11-dist-na 12.0885 APE10-dist-na 16.4392 APE9-dist-out 11.6943 None None None XRAY 2.11 0.199 0.237 B 317.0 258.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzq TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OA P29597 580 867 1187.0 VZJ:901 Type1 Pseudo DFGin 7.3657 12.5647 None -66.43, 170.03 -67.36, 143.81 -70.91, 1.79 25.53, 145.85 78.47, -152.75 in-na in 9.2658 Saltbr-na 999.0 HRD-in -75.49, -66.33 85.17, 12.8 na-out-out SNCaoo out-out ActLoopNT-out 8.1813 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.32, -40.35 APE9-dihe-out -58.15, -35.87 APE8-dihe-out -71.09, -6.29 APE8-rot-na 289.01 APE67-dihe-out -84.78, -2.19 -73.46, 133.77 APE12-dist-na 9.7653 APE11-dist-na 12.0883 APE10-dist-na 16.2662 APE9-dist-out 11.7631 None None None XRAY 2.82 0.181 0.252 A 317.0 257.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 7k7o TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OB P29597 580 868 1187.0 VZJ:901 Type1 Pseudo DFGin 7.7233 12.2472 None -71.51, -175.68 -81.24, 151.01 -79.84, 4.8 35.04, 138.85 72.06, -152.96 in-na in 9.264 Saltbr-na 999.0 HRD-in -101.81, -60.3 88.52, -5.44 na-out-out SNCaoo out-out ActLoopNT-out 8.9231 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.95, -43.16 APE9-dihe-out -55.55, -22.53 APE8-dihe-out -85.45, 0.22 APE8-rot-na 226.83 APE67-dihe-out -83.49, -4.03 -76.46, 136.55 APE12-dist-na 9.6282 APE11-dist-na 12.1992 APE10-dist-na 16.2685 APE9-dist-out 11.2834 None None None XRAY 2.82 0.181 0.252 B 317.0 257.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 7k7o TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QA P29597 580 867 1187.0 VZG:901 Type1 Pseudo DFGin 7.5433 12.5328 None -69.2, 167.5 -63.98, 154.51 -77.3, 7.34 29.56, 146.11 63.89, -146.65 in-na in 9.2815 Saltbr-na 999.0 HRD-in -79.96, -60.41 88.18, -6.56 na-out-out SNCaoo out-out ActLoopNT-out 8.3981 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.8, -37.69 APE9-dihe-out -61.19, -23.02 APE8-dihe-out -86.96, -5.2 APE8-rot-na 283.59 APE67-dihe-out -89.93, 5.32 -68.44, 135.46 APE12-dist-na 9.8237 APE11-dist-na 12.1193 APE10-dist-na 16.4879 APE9-dist-out 11.8015 None None None XRAY 2.27 0.191 0.215 A 317.0 256.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 7k7q TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QB P29597 580 868 1187.0 VZG:901 Type1 Pseudo DFGin 7.5281 12.4836 None -69.63, 166.47 -62.41, 154.32 -76.74, 6.87 29.05, 146.64 63.93, -146.22 in-na in 9.2635 Saltbr-na 999.0 HRD-in -80.84, -60.47 88.54, -6.14 na-out-out SNCaoo out-out ActLoopNT-out 8.3869 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.52, -36.89 APE9-dihe-out -61.37, -23.14 APE8-dihe-out -89.62, -0.64 APE8-rot-na 285.2 APE67-dihe-out -89.84, 4.92 -69.09, 135.18 APE12-dist-na 9.7848 APE11-dist-na 12.1271 APE10-dist-na 16.4591 APE9-dist-out 11.7008 None None None XRAY 2.27 0.191 0.215 B 317.0 251.0 38 24 24 0 [[589, 868], [897, 1171]] 2.0 7k7q TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5A P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.5755 12.8276 None -72.9, 166.16 -62.82, 156.7 -75.2, -1.8 19.44, 155.05 65.85, -157.21 in-na in 9.6283 Saltbr-na 999.0 HRD-in -77.18, -55.68 90.86, -17.89 na-out-out SNCaoo out-out ActLoopNT-out 8.0333 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.91, -37.05 APE9-dihe-out -64.82, -24.45 APE8-dihe-out -87.22, -2.73 APE8-rot-na 294.55 APE67-dihe-out -99.67, 13.88 -62.74, 133.89 APE12-dist-na 9.9661 APE11-dist-na 12.452 APE10-dist-na 16.6371 APE9-dist-out 11.8185 None None None XRAY 2.32 0.187 0.243 A 326.0 257.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 8tb5 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5B P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.3538 12.8302 None -69.46, 162.15 -62.48, 155.25 -75.42, -2.04 28.22, 143.07 66.45, -159.8 in-na in 9.6545 Saltbr-na 999.0 HRD-in -80.42, -58.38 87.54, 2.75 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.71, -36.16 APE9-dihe-out -65.57, -18.78 APE8-dihe-out -89.43, 3.6 APE8-rot-na 301.67 APE67-dihe-out -95.11, 8.54 -67.3, 136.04 APE12-dist-na 10.0198 APE11-dist-na 12.281 APE10-dist-na 16.5002 APE9-dist-out 11.7261 None None None XRAY 2.32 0.187 0.243 B 326.0 257.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 8tb5 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6A P29597 572 869 1187.0 ZOI:901 Type1 Pseudo DFGin 7.5187 12.9175 None -70.48, 163.05 -64.31, 156.7 -77.96, 2.63 25.15, 152.72 70.88, -150.51 in-na in 9.7566 Saltbr-na 999.0 HRD-in -88.04, -58.25 80.3, 7.16 na-out-out SNCaoo out-out ActLoopNT-out 8.0054 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -38.13 APE9-dihe-out -58.13, -23.83 APE8-dihe-out -87.03, -4.8 APE8-rot-na 225.26 APE67-dihe-out -95.58, 10.52 -67.22, 136.28 APE12-dist-na 9.6696 APE11-dist-na 12.2145 APE10-dist-na 16.3433 APE9-dist-out 11.3389 None None None XRAY 1.96 0.195 0.236 A 326.0 263.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 8tb6 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6B P29597 580 867 1187.0 ZOI:901 Type1 Pseudo DFGin 7.5755 12.8341 None -75.19, 161.88 -63.62, 154.56 -77.31, 0.0 28.4, 144.85 69.85, -142.97 in-na in 9.7458 Saltbr-na 999.0 HRD-in -86.92, -60.13 92.81, -6.33 na-out-out SNCaoo out-out ActLoopNT-out 8.2289 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.54, -39.0 APE9-dihe-out -57.31, -25.9 APE8-dihe-out -87.7, -3.61 APE8-rot-na 309.71 APE67-dihe-out -99.75, 10.76 -63.68, 135.57 APE12-dist-na 9.794 APE11-dist-na 12.1163 APE10-dist-na 16.3342 APE9-dist-out 11.4309 None None None XRAY 1.96 0.195 0.236 B 326.0 254.0 35 24 24 0 [[589, 868], [897, 1171]] 2.0 8tb6 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01A P29597 580 868 1187.0 UNL:901 Type1 Pseudo DFGin 7.4943 12.9533 None -78.77, 168.17 -59.3, 158.84 -78.02, -0.56 29.95, 141.01 70.43, -143.96 in-na in 9.8598 Saltbr-na 999.0 HRD-in -88.89, -66.71 89.22, 5.88 na-out-out SNCaoo out-out ActLoopNT-out 8.0202 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.06, -43.56 APE9-dihe-out -60.5, -24.62 APE8-dihe-out -84.02, 0.04 APE8-rot-na 309.1 APE67-dihe-out -102.6, 18.85 -65.89, 133.72 APE12-dist-na 10.0346 APE11-dist-na 12.5583 APE10-dist-na 16.7146 APE9-dist-out 11.3483 None None None XRAY 2.15 0.197 0.24 A 342.0 258.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 5c01 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01B P29597 579 869 1187.0 UNL:901 Type1 Pseudo DFGin 7.503 12.9896 None -83.69, 167.93 -60.38, 156.97 -77.3, 1.6 26.16, 146.38 64.95, -141.34 in-na in 9.8461 Saltbr-na 999.0 HRD-in -91.02, -62.48 85.42, 13.36 na-out-out SNCaoo out-out ActLoopNT-out 8.0537 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.57, -43.79 APE9-dihe-out -56.12, -28.45 APE8-dihe-out -84.03, 3.14 APE8-rot-na 209.42 APE67-dihe-out -101.1, 17.13 -74.09, 134.94 APE12-dist-na 9.9892 APE11-dist-na 12.5924 APE10-dist-na 16.7381 APE9-dist-out 11.6359 None None None XRAY 2.15 0.197 0.24 B 342.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 5c01 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 4GIIA P29597 890 1176 1187.0 0X6:61201 Type1 Inactive DFGin 6.4923 13.9575 None -81.38, -98.04 -79.43, 140.5 -122.16, 30.13 291.74, 87.83 -62.78, -33.65 in-in in 8.2134 Saltbr-in 2.7437 HRD-in -76.73, -46.7 63.15, 9.59 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -89.05, 4.42 APE9-dihe-in -63.44, 130.54 APE8-dihe-in -78.88, 64.67 APE8-rot-na 24.5 APE67-dihe-in -75.7, -5.4 -49.65, -33.9 APE12-dist-na 9.9046 APE11-dist-na 13.0115 APE10-dist-na 9.594 APE9-dist-in 6.6565 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.31 0.221 0.252 A 302.0 287.0 0 31 31 0 [[589, 868], [897, 1171]] 2.0 4gii TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

All / DFGinNone / All

Total number of chains: 855
Active chains: 0
Total number of genes: 137
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 855 100.0% 9H8FA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK SRK2E SRK2E_ARATH 3ZUTA Q940H6 10 319 362.0 No_ligand No_ligand Inactive DFGin 5.3431 15.9671 None -75.48, 118.83 -107.6, 133.45 62.39, 58.1 305.8, 109.47 -67.41, -20.08 out-out out 10.5718 Saltbr-out 10.0563 HRD-out 58.97, -113.21 -49.76, -30.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -152.15 APE8-dihe-in -81.19, 135.09 APE8-rot-out 177.58 APE67-dihe-in -54.58, -33.26 -62.82, -9.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6696 D160A None None XRAY 2.5 0.2 0.251 A 362.0 281.0 14 27 13 14 [[21, 277]] 1.0 3zut Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 6.2e-78 267.7 1.0 256.0 256.0 159 160 161 163 165 50 65 69 137 139 138 140.0 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3ZUTB Q940H6 12 319 362.0 No_ligand No_ligand Inactive DFGin 4.8762 15.3954 None -75.3, 124.36 -115.8, 127.7 65.47, 106.61 311.96, 114.27 -98.96, -3.88 out-out out 10.6176 Saltbr-out 9.3839 HRD-out 62.27, -110.47 -69.62, -9.25 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -85.82, 129.48 APE9-dihe-na -121.55, 97.96 APE8-dihe-in -66.22, 140.7 APE8-rot-out 171.28 APE67-dihe-in -64.23, -22.2 -68.96, 1.14 APE12-dist-out 15.6846 APE11-dist-out 15.3207 APE10-dist-out 20.4461 APE9-dist-out 13.4818 D160A None None XRAY 2.5 0.2 0.251 B 362.0 282.0 11 27 16 11 [[21, 277]] 1.0 3zut Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 6.2e-78 267.7 1.0 256.0 256.0 159 160 161 163 165 50 65 69 137 139 138 140.0 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3ZUUA Q940H6 10 319 362.0 No_ligand No_ligand Inactive DFGin 5.0518 15.7399 None -78.02, 121.88 -112.13, 123.32 74.86, 129.63 308.4, 109.53 -113.78, -23.24 out-out out 10.7083 Saltbr-out 10.9251 HRD-out 60.19, -109.28 -73.61, -9.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -131.12 APE8-dihe-in -66.07, 126.24 APE8-rot-out 190.15 APE67-dihe-in -49.46, -40.23 -66.38, -5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7083 None None None XRAY 2.7 0.24 0.279 A 362.0 281.0 14 27 13 14 [[21, 277]] 1.0 3zuu Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 4.8e-78 268.1 1.0 256.0 256.0 159 160 161 163 165 50 65 69 137 139 138 140.0 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3ZUUB Q940H6 12 319 362.0 No_ligand No_ligand Inactive DFGin 6.1213 15.9199 None -83.59, 133.25 -127.99, 121.87 66.13, 107.74 301.29, 137.89 -97.8, 10.76 out-out out 10.69 Saltbr-out 8.3952 HRD-out 64.51, -102.84 -87.26, 3.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -86.09, 125.1 APE9-dihe-na -111.04, 114.67 APE8-dihe-in -75.16, 145.3 APE8-rot-out 177.67 APE67-dihe-in -53.2, -27.17 -65.59, -13.68 APE12-dist-out 16.2308 APE11-dist-out 16.0914 APE10-dist-out 20.7482 APE9-dist-out 13.521 None None None XRAY 2.7 0.24 0.279 B 362.0 282.0 11 27 16 11 [[21, 277]] 1.0 3zuu Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 4.8e-78 268.1 1.0 256.0 256.0 159 160 161 163 165 50 65 69 137 139 138 140.0 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2I SRK2I_ARATH 3UC3A Q39193 11 319 361.0 No_ligand No_ligand Inactive DFGin 4.2938 12.7917 None -145.36, 92.51 -115.24, 12.18 -77.52, 136.51 307.6, 104.69 -78.46, 76.71 out-out out 10.8037 Saltbr-out 12.1133 HRD-out 54.11, 56.86 -98.01, 161.99 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.06, -25.34 999.0, -53.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D57A,K58A None None XRAY 1.9 0.214 0.23 A 361.0 272.0 19 27 12 15 [[22, 278]] 1.0 3uc3 Arabidopsis thaliana CAMK_SRK2I_ARATH CAMK 7.3e-78 267.4 1.0 256.0 256.0 160 161 162 164 166 51 66 70 138 140 139 141.0 200 187 182 181 180 179 178 177 176 96 Serine/threonine-protein kinase SRK2I
CMGC MPK6 MPK6_ARATH 6DTLB Q39026 33 395 395.0 No_ligand No_ligand Inactive DFGin 6.3694 16.39 None -148.48, 175.65 63.21, 53.93 -61.36, -70.15 305.75, 86.78 64.05, -152.3 in-out in 9.5866 Saltbr-out 4.4225 HRD-in -78.54, -47.34 74.03, -15.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -115.48, -39.06 APE9-dihe-na -70.2, 153.86 APE8-dihe-in -65.87, 121.66 APE8-rot-out 82.86 APE67-dihe-in -63.98, -8.94 -96.81, 19.77 APE12-dist-out 14.5191 APE11-dist-out 17.816 APE10-dist-out 17.246 APE9-dist-out 11.6073 None None None XRAY 2.753 0.209 0.256 B 364.0 357.0 6 27 21 6 [[64, 348]] 1.0 6dtl Arabidopsis thaliana CMGC_MPK6_ARATH CMGC 9.1e-83 284.1 5.0 301.0 297.0 206 207 208 210 212 92 110 114 186 188 187 189.0 246 233 228 227 226 225 224 223 222 145 Mitogen-activated protein kinase 6
STE MKK5 M2K5_ARATH 7XBRB Q8RXG3 65 328 348.0 No_ligand No_ligand Inactive DFGin 6.681 13.8877 None -121.61, -96.16 -63.34, 129.84 -113.98, 24.72 285.0, 121.79 -65.45, -12.08 in-in in 9.3493 Saltbr-in 3.1011 HRD-in -84.14, -49.25 70.89, 8.88 in-in-in SNCiii in-in ActLoopNT-in 3.0418 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.21, 159.6 APE9-dihe-na 105.31, -157.61 APE8-dihe-in -100.67, 121.86 APE8-rot-in 310.05 APE67-dihe-in -60.6, -31.14 -55.32, -44.58 APE12-dist-in 8.1 APE11-dist-in 10.8482 APE10-dist-in 4.9358 APE9-dist-in 3.7194 None SEP66,TPO83,TPO108,TPO215,SEP221 SEP66,TPO83,TPO108,TPO215,SEP221 XRAY 3.2 0.211 0.246 B 295.0 258.0 6 28 28 0 [[70, 325]] 1.0 7xbr Arabidopsis thaliana STE_MKK5_ARATH STE 2e-67 233.2 2.0 257.0 256.0 204 205 206 208 210 99 116 120 184 186 185 187.0 249 232 227 226 225 224 223 222 221 146 Mitogen-activated protein kinase kinase 5
STE MKK5 M2K5_ARATH 7XBRE Q8RXG3 65 328 348.0 No_ligand No_ligand Inactive DFGin 6.5348 14.1017 None -120.22, -97.1 -62.38, 127.72 -111.99, 20.18 283.79, 119.37 -67.64, -29.46 in-in in 9.3343 Saltbr-in 2.8783 HRD-in -89.83, -47.23 59.75, 5.43 in-in-out SNCiio in-out ActLoopNT-in 3.0713 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.46, 164.72 APE9-dihe-na 97.44, -159.58 APE8-dihe-in -119.77, 136.97 APE8-rot-out 62.89 APE67-dihe-in -70.07, -10.3 -69.6, -34.62 APE12-dist-in 8.133 APE11-dist-in 10.7875 APE10-dist-in 4.8252 APE9-dist-in 3.69 None SEP66,TPO83,TPO108,TPO215,SEP221 SEP66,TPO83,TPO108,TPO215,SEP221 XRAY 3.2 0.211 0.246 E 295.0 258.0 6 28 28 0 [[70, 325]] 1.0 7xbr Arabidopsis thaliana STE_MKK5_ARATH STE 2e-67 233.2 2.0 257.0 256.0 204 205 206 208 210 99 116 120 184 186 185 187.0 249 232 227 226 225 224 223 222 221 146 Mitogen-activated protein kinase kinase 5
STE MKK5 M2K5_ARATH 7XBRG Q8RXG3 64 327 348.0 No_ligand No_ligand Inactive DFGin 6.5283 13.6785 None -119.49, -98.14 -64.68, 127.04 -110.22, 19.61 289.02, 116.07 -60.03, -30.61 in-in in 9.4073 Saltbr-in 2.6634 HRD-in -78.13, -40.26 64.7, 6.49 in-in-out SNCiio in-out ActLoopNT-in 2.9109 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.47, 168.52 APE9-dihe-na 124.73, -147.31 APE8-dihe-in -121.15, 133.96 APE8-rot-out 51.88 APE67-dihe-in -73.53, -7.48 -67.23, -41.05 APE12-dist-in 8.3439 APE11-dist-in 11.1487 APE10-dist-in 5.7652 APE9-dist-in 3.8869 None SEP66,TPO83,TPO108,TPO215,SEP221 SEP66,TPO83,TPO108,TPO215,SEP221 XRAY 3.2 0.211 0.246 G 295.0 258.0 6 28 28 0 [[70, 325]] 1.0 7xbr Arabidopsis thaliana STE_MKK5_ARATH STE 2e-67 233.2 2.0 257.0 256.0 204 205 206 208 210 99 116 120 184 186 185 187.0 249 232 227 226 225 224 223 222 221 146 Mitogen-activated protein kinase kinase 5
TKL BAK1 BAK1_ARATH 3TL8G Q94F62 274 578 615.0 No_ligand No_ligand Inactive DFGin 8.7047 15.9151 None -150.19, 66.97 -163.48, 93.86 -92.58, 25.32 292.66, 75.26 -62.11, -33.44 in-in in 8.7844 Saltbr-in 3.4207 HRD-in -73.16, -36.65 62.39, 3.46 in-in-in SNCiii in-in ActLoopNT-in 2.8368 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.06, 156.98 APE9-dihe-na 140.13, -161.91 APE8-dihe-in -117.12, 124.4 APE8-rot-in 293.18 APE67-dihe-inflip 101.45, -17.86 -52.66, 132.04 APE12-dist-in 9.9101 APE11-dist-in 11.2463 APE10-dist-in 5.6222 APE9-dist-in 3.5732 None TPO324,TPO446,TPO449,TPO450 TPO324,TPO446,TPO449,TPO450 XRAY 2.5 0.186 0.238 G 349.0 305.0 0 29 29 0 [[288, 565]] 1.0 3tl8 Arabidopsis thaliana TKL_BAK1_ARATH TKL 7.4e-64 221.9 4.0 266.0 263.0 433 434 435 437 439 317 334 338 413 415 414 416.0 474 462 457 456 455 454 453 452 451 364 BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
TKL BIK1 BIK1_ARATH 5TOSA O48814 52 360 395.0 No_ligand No_ligand Inactive DFGin 6.0802 15.0127 None -62.74, 167.28 -56.72, 147.4 -146.31, 147.51 60.48, 95.84 -80.41, 175.54 out-out out 13.9695 Saltbr-out 11.28 HRD-in -75.04, -37.7 71.23, -32.33 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 113.76, -29.94 999.0, 116.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP253 SEP253 XRAY 2.35 0.239 0.268 A 395.0 280.0 29 30 11 19 [[63, 351]] 1.0 5tos Arabidopsis thaliana TKL_BIK1_ARATH TKL 5.7e-62 215.8 5.0 266.0 262.0 219 220 221 223 225 105 121 125 199 201 200 202.0 261 249 244 243 242 241 240 239 238 151 Serine/threonine-protein kinase BIK1
TKL BIK1 BIK1_ARATH 5TOSB O48814 52 360 395.0 No_ligand No_ligand Inactive DFGin 6.4974 15.2276 None -63.36, 165.7 -58.85, 147.51 -147.14, 147.16 60.84, 95.51 -81.76, 173.49 out-out out 14.0407 Saltbr-out 11.374 HRD-in -74.69, -37.3 70.98, -32.38 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 113.36, -30.28 999.0, 117.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP253 SEP253 XRAY 2.35 0.239 0.268 B 395.0 280.0 29 30 11 19 [[63, 351]] 1.0 5tos Arabidopsis thaliana TKL_BIK1_ARATH TKL 5.7e-62 215.8 5.0 266.0 262.0 219 220 221 223 225 105 121 125 199 201 200 202.0 261 249 244 243 242 241 240 239 238 151 Serine/threonine-protein kinase BIK1
TKL CARK1 CARK1_ARATH 5XD6A Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.2866 13.9895 None -82.23, -179.6 -66.2, 154.72 -113.7, 177.91 45.1, 88.76 -91.38, 112.57 out-na out 13.41 Saltbr-na 13.4762 HRD-in -67.99, -48.34 77.3, -6.84 na-out-none SNCaon out-none ActLoopNT-out 8.2956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 12.83 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 A 305.0 278.0 23 30 13 17 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4.0 266.0 263.0 216 217 218 220 222 97 112 116 196 198 197 199.0 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL CARK1 CARK1_ARATH 5XD6B Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.6295 13.9302 None -77.44, -177.16 -70.67, 157.78 -117.63, 177.11 50.67, 89.87 -85.72, 109.22 out-na out 13.6757 Saltbr-na 14.0861 HRD-in -75.16, -46.81 74.28, -9.17 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -2.12 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 B 305.0 282.0 19 30 11 19 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4.0 266.0 263.0 216 217 218 220 222 97 112 116 196 198 197 199.0 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL CTR1 CTR1_ARATH 3P86B Q05609 543 810 821.0 No_ligand No_ligand Inactive DFGin 5.9967 12.0951 None -121.91, -1.76 -123.79, 154.13 -144.82, 999.0 328.24, 95.27 999.0, 999.0 in-out in 9.309 Saltbr-out 6.3165 HRD-in -67.98, -63.15 80.5, -8.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -98.93 APE8-dihe-in -139.16, 81.75 APE8-rot-out 49.11 APE67-dihe-in -63.86, -17.41 -93.9, 11.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0062 D676N None None XRAY 2.496 0.197 0.232 B 309.0 239.0 29 28 11 17 [[551, 807]] 1.0 3p86 Arabidopsis thaliana TKL_CTR1_ARATH TKL 3.2e-78 268.9 2.0 265.0 264.0 693 694 695 697 699 578 596 600 673 675 674 676.0 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
AGC GRK2 ARBK1_BOVIN 1OMWA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.448 13.0685 None -112.27, -91.9 -67.18, 126.78 -99.0, 7.24 286.96, 109.41 -44.09, -46.49 in-in in 8.9372 Saltbr-in 3.4107 HRD-in -73.22, -52.41 80.02, -28.79 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.71, 128.56 APE9-dihe-na 124.77, -168.54 APE8-dihe-in -89.28, 150.91 APE8-rot-in 295.71 APE67-dihe-in -77.59, -9.92 -72.81, -27.02 APE12-dist-in 10.5885 APE11-dist-in 11.8774 APE10-dist-in 6.1942 APE9-dist-in 3.5029 S670A None None XRAY 2.5 0.216 0.252 A 689.0 614.0 0 26 26 0 [[191, 453]] 1.0 1omw Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7A P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2239 12.3565 None -125.66, -66.29 -94.21, 107.11 -86.73, -10.11 307.87, 97.53 -38.26, -47.46 in-out in 8.8531 Saltbr-out 4.6372 HRD-in -74.94, -45.18 74.24, -26.22 out-in-in SNCoii in-in ActLoopNT-in 2.7715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.74, 123.21 APE9-dihe-na 155.55, 174.57 APE8-dihe-in -86.11, 141.22 APE8-rot-in 314.43 APE67-dihe-in -66.31, -34.76 -64.21, -27.3 APE12-dist-in 9.8313 APE11-dist-in 11.5432 APE10-dist-in 5.5926 APE9-dist-in 3.9926 S670A None None XRAY 4.5 0.226 0.279 A 689.0 608.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7C P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2163 12.2674 None -130.34, -66.38 -92.79, 106.85 -85.97, -13.2 309.12, 95.06 -35.96, -48.47 in-out in 8.8136 Saltbr-out 4.7358 HRD-in -75.86, -48.89 75.97, -29.41 out-in-in SNCoii in-in ActLoopNT-in 2.721 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.29, 128.8 APE9-dihe-na 145.96, 173.8 APE8-dihe-in -87.44, 141.12 APE8-rot-in 314.72 APE67-dihe-in -67.09, -36.43 -60.22, -25.52 APE12-dist-in 9.7747 APE11-dist-in 11.5691 APE10-dist-in 5.6074 APE9-dist-in 4.0582 S670A None None XRAY 4.5 0.226 0.279 C 689.0 607.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7D P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2341 12.3436 None -128.88, -67.33 -92.65, 105.41 -87.88, -10.71 307.83, 96.53 -37.49, -49.46 in-out in 8.801 Saltbr-out 4.7459 HRD-in -72.13, -45.13 72.62, -27.86 out-in-in SNCoii in-in ActLoopNT-in 2.7633 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.27, 125.22 APE9-dihe-na 149.39, 173.11 APE8-dihe-in -84.5, 141.69 APE8-rot-in 315.18 APE67-dihe-in -66.11, -35.98 -62.26, -27.83 APE12-dist-in 9.7362 APE11-dist-in 11.4974 APE10-dist-in 5.5333 APE9-dist-in 4.0286 S670A None None XRAY 4.5 0.226 0.279 D 689.0 599.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 2BCJA P21146 28 667 689.0 No_ligand No_ligand Inactive DFGin 5.1531 12.3754 None -114.23, -125.71 -23.26, 91.28 -81.33, 0.62 275.63, 158.44 -51.51, -42.54 in-in in 8.6198 Saltbr-in 2.6334 HRD-in -86.19, -45.87 70.94, -23.92 in-in-in SNCiii in-in ActLoopNT-in 2.7186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.73, 137.19 APE9-dihe-na 118.03, -177.98 APE8-dihe-in -75.0, 121.63 APE8-rot-in 302.92 APE67-dihe-in -97.57, -19.7 -76.89, 19.37 APE12-dist-in 11.0395 APE11-dist-in 11.9406 APE10-dist-in 6.0057 APE9-dist-in 3.715 S670A None None XRAY 3.061 0.236 0.292 A 689.0 624.0 0 26 26 0 [[191, 453]] 1.0 2bcj Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3UZSA P21146 29 671 689.0 No_ligand No_ligand Inactive DFGin 5.731 11.1485 None -107.21, -110.21 -68.72, 97.64 -52.38, -56.06 299.08, 3.09 42.56, -75.63 in-out in 9.0047 Saltbr-out 3.9207 HRD-in -77.33, -41.02 60.69, 32.77 out-in-out SNCoio in-out ActLoopNT-in 3.5286 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -98.18, 142.14 APE9-dihe-na 139.16, 169.96 APE8-dihe-in -74.03, 124.78 APE8-rot-in 315.02 APE67-dihe-out 166.07, -43.85 -59.08, 78.84 APE12-dist-in 10.2386 APE11-dist-in 12.0969 APE10-dist-in 6.31 APE9-dist-in 3.5138 S670A None None XRAY 4.52 0.188 0.268 A 689.0 609.0 20 26 26 0 [[191, 453]] 1.0 3uzs Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3UZTA P21146 30 656 689.0 No_ligand No_ligand Inactive DFGin 5.216 12.499 None -94.28, -95.77 -83.37, 90.84 -54.75, -37.85 271.69, 47.64 -2.65, -69.38 in-out in 8.8257 Saltbr-out 5.0807 HRD-in -72.79, -37.98 67.02, -27.54 out-in-in SNCoii in-in ActLoopNT-in 3.085 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.51, 148.65 APE9-dihe-na 138.76, 168.6 APE8-dihe-in -71.39, 126.55 APE8-rot-in 294.92 APE67-dihe-in -71.95, -17.71 -54.34, -25.29 APE12-dist-in 9.5328 APE11-dist-in 12.0098 APE10-dist-in 5.9885 APE9-dist-in 3.8685 S670A None None XRAY 3.51 0.22 0.317 A 689.0 586.0 12 26 26 0 [[191, 453]] 1.0 3uzt Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PSCA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.4842 12.8251 None -112.1, -116.4 -50.02, 128.26 -100.71, 13.15 287.53, 88.47 -45.02, -46.74 in-in in 8.8883 Saltbr-in 3.1136 HRD-in -73.4, -47.49 67.75, 0.38 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.59, 142.02 APE9-dihe-na 121.44, 174.37 APE8-dihe-in -79.3, 138.73 APE8-rot-in 323.05 APE67-dihe-in -80.94, 3.9 -61.06, -31.71 APE12-dist-in 10.1172 APE11-dist-in 11.7629 APE10-dist-in 5.9289 APE9-dist-in 3.1916 S670A None None XRAY 2.67 0.225 0.257 A 695.0 614.0 0 26 26 0 [[191, 453]] 1.0 3psc Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PVUA P21146 30 668 689.0 QRW:800 Type1 Inactive DFGin 5.4293 12.5496 None -114.2, -126.97 -29.78, 116.79 -95.83, 7.38 283.37, 161.7 -55.56, -22.85 in-in in 8.7486 Saltbr-in 2.9863 HRD-in -71.34, -46.23 80.59, -11.92 in-in-in SNCiii in-in ActLoopNT-in 2.9271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.26, 142.91 APE9-dihe-na 117.3, -165.9 APE8-dihe-in -102.62, 148.45 APE8-rot-in 314.0 APE67-dihe-in -77.54, 11.33 -67.23, -35.08 APE12-dist-in 10.2837 APE11-dist-in 11.8902 APE10-dist-in 6.1863 APE9-dist-in 3.4202 S670A None None XRAY 2.48 0.229 0.274 A 695.0 609.0 0 26 26 0 [[191, 453]] 1.0 3pvu Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PVWA P21146 29 668 689.0 QRX:800 Type1 Inactive DFGin 5.249 12.3972 None -104.93, -94.33 -60.0, 121.61 -95.37, 6.96 285.31, 4.38 -65.85, -19.47 in-in in 8.7495 Saltbr-in 3.07 HRD-in -69.01, -52.71 78.6, -13.88 in-in-in SNCiii in-in ActLoopNT-in 2.9188 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.25, 142.6 APE9-dihe-na 127.77, 176.65 APE8-dihe-in -84.9, 148.79 APE8-rot-in 327.3 APE67-dihe-in -77.16, 13.46 -65.86, -42.83 APE12-dist-in 10.7375 APE11-dist-in 12.1865 APE10-dist-in 6.4122 APE9-dist-in 3.337 S670A None None XRAY 2.49 0.239 0.285 A 695.0 613.0 0 26 26 0 [[191, 453]] 1.0 3pvw Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC PRKACA KAPCA_BOVIN 4C35A P00517 11 351 351.0 NU3:61351 Type1.5_Back Inactive DFGin 5.96 15.1175 None -103.23, -88.31 -54.39, 108.88 -97.56, 11.02 265.67, 64.27 -54.79, -37.29 in-in in 9.1847 Saltbr-in 2.7744 HRD-in -78.97, -53.39 72.53, 0.25 in-in-in SNCiii in-in ActLoopNT-in 2.8688 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.98, 158.62 APE9-dihe-na 121.3, -169.27 APE8-dihe-in -106.38, 130.41 APE8-rot-in 302.02 APE67-dihe-in -58.09, -26.56 -41.09, -54.15 APE12-dist-in 8.7429 APE11-dist-in 11.6126 APE10-dist-in 5.9626 APE9-dist-in 3.4271 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.19 0.186 0.24 A 351.0 341.0 0 25 25 0 [[44, 298]] 1.0 4c35 Bos taurus AGC_PRKACA_BOVIN AGC 7.8e-94 319.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC CDK7 G0SFC6_CHATD 6Z4XB G0SFC6 78 399 437.0 AGS:501 ATPlike Inactive DFGin 6.0664 15.963 None -120.32, -64.48 -72.18, 111.3 -111.88, 18.28 274.56, 83.55 -65.42, -11.7 in-out in 8.9011 Saltbr-out 3.7194 HRD-in -82.6, -50.25 63.05, 25.15 out-in-in SNCoii in-in ActLoopNT-in 2.7476 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.45, 163.36 APE9-dihe-na 70.87, 128.98 APE8-dihe-in -54.32, 144.95 APE8-rot-in 303.7 APE67-dihe-in -58.5, -22.2 -48.9, -49.43 APE12-dist-in 13.1214 APE11-dist-in 10.3276 APE10-dist-in 6.1584 APE9-dist-in 3.0434 None None None XRAY 2.98 0.205 0.246 B 437.0 322.0 0 28 28 0 [[92, 383]] 1.0 6z4x Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2.0 300.0 299.0 237 238 239 241 243 122 141 145 217 219 218 220.0 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
CMGC CDK7 G0SFC6_CHATD 6Z4XE G0SFC6 77 399 437.0 AGS:501 ATPlike Inactive DFGin 6.0452 15.8914 None -120.83, -65.38 -72.38, 111.16 -111.28, 19.39 275.38, 85.23 -65.84, -12.59 in-out in 8.9023 Saltbr-out 3.6666 HRD-in -79.74, -48.62 65.81, 23.05 out-in-in SNCoii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.65, 161.76 APE9-dihe-na 74.19, 130.39 APE8-dihe-in -54.74, 142.95 APE8-rot-in 302.5 APE67-dihe-in -58.43, -23.34 -50.65, -48.02 APE12-dist-in 13.252 APE11-dist-in 10.4227 APE10-dist-in 6.1469 APE9-dist-in 3.1587 None None None XRAY 2.98 0.205 0.246 E 437.0 323.0 0 28 28 0 [[92, 383]] 1.0 6z4x Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2.0 300.0 299.0 237 238 239 241 243 122 141 145 217 219 218 220.0 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5855 12.8524 None -92.38, -13.16 -130.85, 61.75 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.5425 APE10-dist-na 5.1047 APE9-dist-na 11.5716 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438.0 405.0 0 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6162 12.9181 None -91.62, -15.83 -130.65, 63.54 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.5804 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.1748 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.8933 APE11-dist-na 5.4782 APE10-dist-na 5.0793 APE9-dist-na 11.8701 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438.0 406.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.4924 12.6474 None -89.83, -13.71 -129.71, 95.5 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.5683 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.0361 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.8695 APE11-dist-na 5.4118 APE10-dist-na 5.1039 APE9-dist-na 11.7021 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438.0 397.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5811 12.83 None -92.56, -14.61 -129.54, 61.33 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.6323 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.9797 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.8492 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.6129 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438.0 407.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.7667 None -90.87, -14.73 -130.14, 65.48 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.9331 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.9622 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.8671 APE11-dist-na 5.5056 APE10-dist-na 4.9898 APE9-dist-na 11.6524 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438.0 394.0 10 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6574 12.9278 None -90.71, -14.62 -131.6, 64.5 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.6193 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.8968 APE11-dist-na 5.4715 APE10-dist-na 4.9808 APE9-dist-na 11.7452 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438.0 408.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.3451 12.7272 None -90.69, -14.9 -130.76, 66.96 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.6864 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.9562 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.8855 APE11-dist-na 5.4414 APE10-dist-na 4.9896 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438.0 397.0 11 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5482 12.9926 None -92.58, -12.35 -130.21, 41.87 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.5649 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.1131 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.8973 APE11-dist-na 5.5511 APE10-dist-na 5.0041 APE9-dist-na 11.6791 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438.0 407.0 7 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.6339 13.1429 None -107.98, -0.69 -128.2, 34.36 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.8242 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.7342 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.8957 APE11-dist-na 5.5654 APE10-dist-na 4.767 APE9-dist-na 12.0929 None None None XRAY 2.59 0.185 0.221 A 438.0 403.0 9 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6566 13.4069 None -109.51, -3.14 -128.47, 33.06 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.6072 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.7399 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.8265 APE11-dist-na 5.6867 APE10-dist-na 4.9609 APE9-dist-na 11.8917 None None None XRAY 2.59 0.185 0.221 B 438.0 412.0 10 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.6729 13.1643 None -108.29, -3.21 -129.06, 34.16 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.7221 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.9283 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.8857 APE11-dist-na 5.6634 APE10-dist-na 4.9314 APE9-dist-na 11.8945 None None None XRAY 2.59 0.185 0.221 C 438.0 404.0 8 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.7302 13.2458 None -109.91, -2.89 -127.7, 32.83 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.6595 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.8928 APE11-dist-na 5.6895 APE10-dist-na 4.875 APE9-dist-na 11.9374 None None None XRAY 2.59 0.185 0.221 D 438.0 411.0 11 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PKNG Q8NM29_CORGL 7MXBA Q8NM29 52 728 751.0 MAP:60901 Type1 Inactive DFGin 5.0742 11.2741 None -118.68, -14.76 -87.76, 64.62 -67.83, -34.44 189.61, 46.83 -64.01, -11.36 out-out out 16.9823 Saltbr-out 16.8857 HRD-in -83.43, -36.89 76.36, -45.68 out-in-in SNCoii in-in ActLoopNT-in 2.8687 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.58, 61.09 APE9-dihe-na -82.25, -173.13 APE8-dihe-in -124.32, 123.78 APE8-rot-in 301.48 APE67-dihe-inflip 105.13, -19.5 -60.8, 129.28 APE12-dist-in 10.9096 APE11-dist-in 8.2322 APE10-dist-in 5.3485 APE9-dist-in 4.1669 None None None XRAY 2.2 0.211 0.246 A 700.0 672.0 0 24 24 0 [[104, 300]] 1.0 7mxb Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 4.9e-20 78.5 1.0 186.0 186.0 246 247 248 250 252 134 151 155 227 229 228 230.0 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.3569 13.1741 None -145.49, -53.43 -88.36, 87.6 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.1764 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.1638 APE11-dist-in 13.9361 APE10-dist-out 17.3588 APE9-dist-out 9.4145 None None None XRAY 2.0 0.203 0.218 A 290.0 290.0 0 30 30 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.3e-138 465.4 1.0 265.0 265.0 224 225 226 228 230 106 120 124 199 201 200 202.0 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
OTHER PAN3 PAN3_DROME 4BWPA Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 8.9872 13.2943 None -64.87, -46.72 -145.48, 65.79 -71.61, -40.0 313.19, 999.0 -67.11, -37.22 out-na out 16.8319 Saltbr-na 999.0 HRD-in -50.58, -30.55 79.2, -55.76 na-out-na SNCaoa out-na ActLoopNT-out 6.6977 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -83.44, -6.17 APE9-dihe-na -63.0, 138.21 APE8-dihe-na -120.41, 140.18 APE8-rot-na 194.81 APE67-dihe-na -113.46, 118.54 -59.4, -45.27 APE12-dist-na 5.3059 APE11-dist-na 5.8273 APE10-dist-na 8.8341 APE9-dist-na 12.3414 None None None XRAY 3.6 0.222 0.269 A 448.0 386.0 23 18 18 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1.0 288.0 288.0 564 565 566 568 570 423 438 442 545 547 546 548.0 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_DROME 4BWPB Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 9.7361 13.9813 None -68.02, -47.7 -135.41, 45.28 -65.56, -36.8 296.47, 999.0 -63.81, -39.61 out-na out 16.5445 Saltbr-na 999.0 HRD-in -58.26, -35.46 80.55, -56.51 na-out-na SNCaoa out-na ActLoopNT-out 5.9619 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.2, -6.77 APE9-dihe-na -69.16, 143.64 APE8-dihe-na -96.5, 127.2 APE8-rot-na 212.33 APE67-dihe-na -115.77, 110.79 -63.6, -38.16 APE12-dist-na 4.419 APE11-dist-na 6.01 APE10-dist-na 8.8537 APE9-dist-na 11.2901 None None None XRAY 3.6 0.222 0.269 B 448.0 372.0 26 18 18 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1.0 288.0 288.0 564 565 566 568 570 423 438 442 545 547 546 548.0 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
TYR PTK2 FAK1_CHICK 4D4RA Q00944 414 685 1053.0 No_ligand No_ligand Inactive DFGin 6.7525 16.3152 None -128.64, 175.12 33.48, 60.17 -127.21, 999.0 60.14, 81.77 999.0, 999.0 in-out in 7.5542 Saltbr-out 4.2747 HRD-in -77.09, -46.72 78.72, -6.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.07 APE8-dihe-in -82.55, 72.75 APE8-rot-na 32.3 APE67-dihe-in -68.58, -11.96 -57.72, -42.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6768 None None None XRAY 1.55 0.202 0.221 A 276.0 251.0 21 29 11 18 [[422, 678]] 1.0 4d4r Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D4RB Q00944 412 684 1053.0 No_ligand No_ligand Inactive DFGin 7.0229 17.7358 None -78.09, 178.28 -54.92, 128.48 -75.07, -16.05 303.31, 165.11 -65.19, -11.08 out-out out 10.2314 Saltbr-out 10.1999 HRD-in -77.54, -48.96 77.86, -1.75 out-out-none SNCoon out-none ActLoopNT-out 10.0512 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.59 APE8-dihe-in -81.78, 61.99 APE8-rot-na 34.83 APE67-dihe-in -67.78, -12.73 -54.67, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7799 None None None XRAY 1.55 0.202 0.221 B 276.0 270.0 3 29 26 3 [[422, 678]] 1.0 4d4r Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D4SA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.3347 14.4902 None -114.18, -4.67 -150.83, 135.97 -129.43, 999.0 291.59, 99.53 999.0, 999.0 in-in in 7.8702 Saltbr-in 2.9877 HRD-in -76.62, -49.37 85.0, -10.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 143.71 APE9-dihe-in -71.69, 139.37 APE8-dihe-in -80.22, 72.42 APE8-rot-na 32.17 APE67-dihe-in -66.95, -17.13 -56.96, -41.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.103 None None None XRAY 2.0 0.207 0.225 A 276.0 255.0 17 29 12 17 [[422, 678]] 1.0 4d4s Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D4YA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.0184 14.5145 None -118.29, -10.26 -147.25, 131.73 -119.37, 999.0 297.41, 102.39 999.0, 999.0 in-in in 7.7981 Saltbr-in 2.4441 HRD-in -81.89, -51.68 81.97, -7.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -42.9 APE9-dihe-in -67.29, 140.52 APE8-dihe-in -79.28, 66.93 APE8-rot-na 16.31 APE67-dihe-in -68.8, -8.86 -56.17, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2511 None None None XRAY 1.8 0.189 0.227 A 276.0 255.0 17 29 12 17 [[422, 678]] 1.0 4d4y Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D58A Q00944 414 686 1053.0 No_ligand No_ligand Inactive DFGin 5.4479 14.9497 None -119.32, -6.79 -143.39, 120.13 -112.99, 999.0 292.94, 94.83 999.0, 999.0 in-in in 8.2041 Saltbr-in 2.7173 HRD-in -82.22, -48.88 82.65, -10.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.86 APE8-dihe-in -79.5, 65.59 APE8-rot-na 31.69 APE67-dihe-in -68.56, -13.14 -56.02, -40.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2547 None None None XRAY 1.95 0.197 0.228 A 276.0 255.0 18 29 11 18 [[422, 678]] 1.0 4d58 Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D5KA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.582 15.122 None -117.73, -5.95 -151.01, 133.04 -124.81, 999.0 284.01, 85.38 999.0, 999.0 in-in in 7.8884 Saltbr-in 3.5838 HRD-in -86.7, -47.97 80.45, -6.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -43.63 APE9-dihe-in -60.17, 136.23 APE8-dihe-in -79.08, 66.16 APE8-rot-na 27.0 APE67-dihe-in -72.5, -9.93 -52.21, -39.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2332 None None None XRAY 1.75 0.19 0.214 A 276.0 255.0 17 29 12 17 [[422, 678]] 1.0 4d5k Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY3A Q00944 35 686 1053.0 No_ligand No_ligand Inactive DFGin 6.5669 14.4517 None -135.16, 170.63 86.31, -91.36 58.85, 65.75 299.77, 89.22 -131.55, 157.07 in-out in 8.2587 Saltbr-out 3.768 HRD-in -98.85, -42.65 73.64, -10.05 out-out-out SNCooo out-out ActLoopNT-out 12.3607 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -84.38, 179.3 APE9-dihe-in -128.41, 160.02 APE8-dihe-in -77.79, 72.21 APE8-rot-na 27.16 APE67-dihe-in -64.5, -27.16 -60.23, -43.57 APE12-dist-na 14.9643 APE11-dist-na 15.5934 APE10-dist-na 17.373 APE9-dist-out 8.6292 None None None EM 6.32 999.0 999.0 A 658.0 600.0 10 29 19 10 [[422, 678]] 1.0 6ty3 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY3B Q00944 35 686 1053.0 No_ligand No_ligand Inactive DFGin 6.5666 14.4511 None -135.19, 170.62 86.26, -91.32 58.84, 65.75 299.77, 89.17 -131.52, 157.04 in-out in 8.2593 Saltbr-out 3.7672 HRD-in -98.85, -42.61 73.64, -10.1 out-out-out SNCooo out-out ActLoopNT-out 12.3602 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -84.36, 179.28 APE9-dihe-in -128.39, 160.01 APE8-dihe-in -77.75, 72.19 APE8-rot-na 27.19 APE67-dihe-in -64.56, -27.16 -60.28, -43.5 APE12-dist-na 14.9649 APE11-dist-na 15.5935 APE10-dist-na 17.3733 APE9-dist-out 8.6295 None None None EM 6.32 999.0 999.0 B 658.0 600.0 10 29 19 10 [[422, 678]] 1.0 6ty3 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2JKMA Q00944 413 686 1053.0 BII:1687 Type1 Inactive DFGin 6.9792 15.5966 None -114.99, -166.2 1.63, 119.82 87.35, -47.95 314.75, 124.67 -93.91, 178.82 in-in in 7.4247 Saltbr-in 2.8047 HRD-in -72.67, -52.48 88.19, -13.59 in-out-out SNCioo out-out ActLoopNT-out 14.999 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.01 APE8-dihe-in -71.46, 57.0 APE8-rot-na 27.37 APE67-dihe-in -75.95, 0.41 -40.68, -47.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1436 None None None XRAY 2.31 0.211 0.272 A 276.0 260.0 14 29 15 14 [[422, 678]] 1.0 2jkm Gallus gallus TYR_PTK2_CHICK TYR 1.4e-93 318.9 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2J0MB Q00944 414 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.9718 14.2866 None -122.76, 167.67 145.4, -137.08 -124.29, 100.35 290.36, 64.77 -132.69, 154.11 in-in in 7.4678 Saltbr-in 2.4434 HRD-in -71.25, -49.34 81.19, -3.46 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.23 APE8-dihe-in -85.72, 66.92 APE8-rot-na 31.09 APE67-dihe-in -64.84, -11.69 -52.92, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3786 None None None XRAY 2.8 0.224 0.282 B 276.0 257.0 16 29 13 16 [[422, 678]] 1.0 2j0m Gallus gallus TYR_PTK2_CHICK TYR 3.3e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2JKQA Q00944 414 686 1053.0 VG8:1687 Type1 Inactive DFGin 6.4335 15.7696 None -75.88, 179.74 -51.42, 124.37 -59.35, -36.75 304.41, 5.5 -52.05, -42.43 in-in in 7.4943 Saltbr-in 2.6234 HRD-in -66.06, -52.83 77.77, -12.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.31 APE8-dihe-in -81.47, 65.67 APE8-rot-na 31.77 APE67-dihe-in -69.2, -7.68 -48.0, -45.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8832 None None None XRAY 2.6 0.217 0.262 A 276.0 258.0 15 29 14 15 [[422, 678]] 1.0 2jkq Gallus gallus TYR_PTK2_CHICK TYR 3.3e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2JKKA Q00944 413 684 1053.0 BI9:1686 Type1 Inactive DFGin 6.6615 15.9464 None -75.15, -171.72 -62.78, 135.39 -69.82, -36.92 292.96, 7.69 -58.64, -47.49 in-in in 7.4664 Saltbr-in 2.7948 HRD-in -67.23, -54.57 79.75, -14.16 in-out-none SNCion out-none ActLoopNT-out 10.5203 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.56 APE8-dihe-in -81.25, 65.87 APE8-rot-na 28.94 APE67-dihe-in -64.8, -17.36 -41.67, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9613 None None None XRAY 2.0 0.182 0.236 A 276.0 258.0 14 29 15 14 [[422, 678]] 1.0 2jkk Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2JKOA Q00944 415 686 1053.0 BIJ:1687 Type1 Inactive DFGin 6.8239 16.2882 None -76.65, 177.09 -51.97, 132.66 -73.02, -22.84 294.23, 6.85 -74.57, -42.86 in-in in 8.264 Saltbr-in 3.5763 HRD-in -81.96, -48.92 77.27, -4.29 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.22 APE8-dihe-in -78.31, 62.64 APE8-rot-na 29.54 APE67-dihe-in -67.04, -13.81 -48.71, -43.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9324 None None None XRAY 1.65 0.19 0.217 A 276.0 256.0 16 29 13 16 [[422, 678]] 1.0 2jko Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4BRXA Q00944 413 684 1053.0 KGW:1685 Type1 Inactive DFGin 6.5674 15.8037 None -85.04, -171.69 -52.6, 140.21 -75.53, -32.77 290.76, 3.08 -64.53, -44.35 in-in in 7.2763 Saltbr-in 2.8175 HRD-in -72.91, -56.18 75.54, -1.8 in-out-out SNCioo out-out ActLoopNT-out 10.4289 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.09 APE8-dihe-in -77.77, 68.02 APE8-rot-na 18.27 APE67-dihe-in -64.57, -19.31 -48.57, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2028 None None None XRAY 2.05 0.199 0.239 A 276.0 260.0 12 29 17 12 [[422, 678]] 1.0 4brx Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4C7TA Q00944 414 684 1053.0 5RI:1685 Type1 Inactive DFGin 6.5328 15.8402 None -77.4, -179.92 -52.87, 136.35 -71.95, -38.06 294.7, 1.19 -59.39, -44.61 in-in in 7.5173 Saltbr-in 2.969 HRD-in -72.59, -59.08 84.11, -4.81 in-out-none SNCion out-none ActLoopNT-out 10.4308 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.59 APE8-dihe-in -78.35, 70.91 APE8-rot-na 26.06 APE67-dihe-in -65.2, -16.6 -50.79, -47.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8934 None None None XRAY 2.05 0.22 0.246 A 276.0 259.0 12 29 17 12 [[422, 678]] 1.0 4c7t Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D5HA Q00944 415 686 1053.0 9RM:1687 Type1 Inactive DFGin 8.7894 16.1789 None -119.76, -8.44 -152.2, 131.56 -67.1, 999.0 180.84, 34.18 999.0, 999.0 in-out in 7.9099 Saltbr-out 3.7146 HRD-in -79.33, -48.38 80.51, -4.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.09 APE9-dihe-in -60.1, 142.63 APE8-dihe-in -82.47, 68.46 APE8-rot-na 31.45 APE67-dihe-in -67.73, -13.99 -56.02, -40.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1679 None None None XRAY 1.75 0.183 0.205 A 276.0 255.0 17 29 12 17 [[422, 678]] 1.0 4d5h Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6GCRA Q00944 413 684 1053.0 EUW:701 Type1 Inactive DFGin 6.7381 16.103 None -70.87, -166.97 -65.32, 125.1 -57.74, -34.57 287.47, 8.46 -73.02, -37.86 in-in in 7.5668 Saltbr-in 2.463 HRD-in -75.05, -55.09 81.04, -5.76 in-out-out SNCioo out-out ActLoopNT-out 10.4188 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.27 APE8-dihe-in -77.73, 61.32 APE8-rot-na 29.84 APE67-dihe-in -67.52, -6.96 -49.75, -48.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3585 None None None XRAY 2.3 0.214 0.262 A 276.0 258.0 14 29 15 14 [[422, 678]] 1.0 6gcr Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6GCWA Q00944 414 685 1053.0 EUQ:701 Type1 Inactive DFGin 6.2848 15.2282 None -130.25, -162.76 64.22, 75.01 -107.3, 999.0 290.51, 75.53 999.0, 999.0 in-out in 8.033 Saltbr-out 4.3767 HRD-in -81.64, -46.43 83.77, -4.99 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.84 APE8-dihe-in -78.48, 68.9 APE8-rot-na 34.42 APE67-dihe-in -73.52, -10.12 -55.06, -39.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3952 None None None XRAY 2.0 0.22 0.274 A 276.0 254.0 18 29 11 18 [[422, 678]] 1.0 6gcw Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6GCWB Q00944 414 686 1053.0 EUQ:701 Type1 Inactive DFGin 6.5394 15.8369 None -81.1, -172.36 -60.09, 131.66 -68.99, -32.35 293.15, 10.83 -65.72, -42.14 in-in in 7.5733 Saltbr-in 2.6791 HRD-in -76.57, -51.51 74.74, 1.93 in-out-out SNCioo out-out ActLoopNT-out 11.0698 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.67 APE8-dihe-in -80.93, 60.16 APE8-rot-na 31.79 APE67-dihe-in -70.89, -7.66 -53.84, -42.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8215 None None None XRAY 2.0 0.22 0.274 B 276.0 259.0 14 29 15 14 [[422, 678]] 1.0 6gcw Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6GCXA Q00944 413 686 1053.0 EUW:701 Type1 Inactive DFGin 6.7791 16.4446 None -72.0, 177.39 -57.13, 134.48 -70.38, -29.96 294.86, 177.92 -65.58, -46.38 in-in in 8.091 Saltbr-in 3.0472 HRD-in -82.56, -49.93 78.9, -6.95 in-out-out SNCioo out-out ActLoopNT-out 10.8456 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.29 APE8-dihe-in -79.72, 63.89 APE8-rot-na 33.8 APE67-dihe-in -69.74, -9.01 -53.44, -42.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0095 None None None XRAY 1.553 0.186 0.219 A 276.0 258.0 16 29 15 14 [[422, 678]] 1.0 6gcx Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2J0JA Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.9183 14.3851 None -123.19, 169.5 101.29, -103.63 66.49, 28.41 317.16, 97.31 -90.27, 177.52 in-in in 8.1193 Saltbr-in 2.703 HRD-in -78.32, -40.43 79.32, -8.22 in-out-out SNCioo out-out ActLoopNT-out 12.4634 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.84 APE8-dihe-in -80.69, 57.63 APE8-rot-na 26.07 APE67-dihe-in -61.42, -10.9 -40.75, -50.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8492 None None None XRAY 2.8 0.22 0.274 A 656.0 611.0 10 29 19 10 [[422, 678]] 1.0 2j0j Gallus gallus TYR_PTK2_CHICK TYR 3.1e-92 314.9 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2J0KA Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.8398 14.5218 None -94.55, -93.91 -78.14, -58.62 58.67, 36.74 310.17, 120.14 -115.82, 158.23 in-in in 8.1674 Saltbr-in 2.8344 HRD-in -98.8, -33.31 77.39, -21.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 52.29 APE9-dihe-in -82.72, 133.73 APE8-dihe-in -69.87, 64.39 APE8-rot-na 25.61 APE67-dihe-in -58.59, -19.95 -50.1, -51.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.019 APE9-dist-out 8.8097 None None None XRAY 3.0 0.237 0.299 A 656.0 598.0 15 29 14 15 [[422, 678]] 1.0 2j0k Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2J0KB Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.7997 13.9437 None -96.91, -85.38 -80.15, -63.34 50.19, 5.1 328.51, 122.72 -57.61, 145.44 in-in in 8.0424 Saltbr-in 3.1137 HRD-in -78.83, -42.91 75.23, -10.09 in-out-out SNCioo out-out ActLoopNT-out 10.5128 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.8 APE8-dihe-in -80.14, 57.93 APE8-rot-na 30.91 APE67-dihe-in -67.94, -7.65 -42.39, -46.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.247 None None None XRAY 3.0 0.237 0.299 B 656.0 612.0 14 29 15 14 [[422, 678]] 1.0 2j0k Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR SRC SRC_CHICK 2QI8B P00523 258 533 533.0 No_ligand No_ligand Inactive DFGin 7.8612 16.8758 None -77.97, -158.42 -74.03, 88.42 -88.4, -16.79 67.11, 83.76 -79.48, -52.26 out-out out 13.8694 Saltbr-out 14.9403 HRD-in -91.82, -50.89 84.66, -18.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -12.95 APE8-rot-na 23.3 APE67-dihe-in -67.65, -27.2 -77.97, -14.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.32 0.209 0.28 B 286.0 249.0 27 29 13 16 [[267, 518]] 1.0 2qi8 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3OF0A P00523 257 533 533.0 No_ligand No_ligand Inactive DFGin 8.079 18.4892 None -146.9, -179.96 52.09, 63.41 -111.3, 49.26 188.56, 13.62 173.82, 999.0 in-none in 9.3325 Saltbr-none 999.0 HRD-in -91.09, -54.45 90.0, -20.95 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.7 APE8-dihe-out -72.72, 48.33 APE8-rot-na 342.06 APE67-dihe-in -71.97, -7.32 -51.77, -40.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.1476 L317I None None XRAY 2.7 0.235 0.262 A 286.0 260.0 17 29 12 17 [[267, 518]] 1.0 3of0 Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3OF0B P00523 257 533 533.0 No_ligand No_ligand Inactive DFGin 6.6309 17.2915 None -121.44, 158.78 55.92, 63.67 -66.14, -42.29 187.05, 74.23 -124.0, 999.0 out-none out 10.1078 Saltbr-none 999.0 HRD-in -83.6, -45.43 85.17, -21.22 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.75 APE8-dihe-in -77.48, 50.61 APE8-rot-na 348.02 APE67-dihe-in -69.18, -14.01 -51.46, -45.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3734 L317I None None XRAY 2.7 0.235 0.262 B 286.0 251.0 26 29 12 17 [[267, 518]] 1.0 3of0 Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3EN7B P00523 260 533 533.0 No_ligand No_ligand Inactive DFGin 7.013 14.9512 None -143.73, 172.49 60.52, 92.2 -105.14, 999.0 302.26, 91.11 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.81, -53.6 81.99, -18.76 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 22.06 APE8-rot-na 33.19 APE67-dihe-in -63.48, -28.45 -41.55, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.81 0.209 0.257 B 286.0 237.0 37 29 10 19 [[267, 518]] 1.0 3en7 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5D10B P00523 257 533 533.0 563:601 Type1 Inactive DFGin 7.4289 16.4733 None -133.04, -178.61 -87.44, -158.09 -136.33, 84.77 256.13, 100.97 150.07, -170.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.07, -45.84 84.08, -10.37 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.73 APE8-rot-na 24.74 APE67-dihe-in -54.59, -33.13 -71.82, -28.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.7 0.272 0.359 B 286.0 247.0 30 29 12 17 [[267, 518]] 1.0 5d10 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 6HVFA P00523 257 533 533.0 GUT:601 Type1 Inactive DFGin 7.457 16.4853 None -138.59, -176.51 57.27, 56.24 -78.59, 999.0 275.5, 89.04 999.0, 999.0 in-in in 8.1899 Saltbr-in 3.0031 HRD-in -83.09, -59.73 92.18, -12.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.35 APE8-rot-na 32.2 APE67-dihe-in -65.01, -20.46 -56.56, -37.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.1 0.212 0.245 A 286.0 246.0 31 29 10 19 [[267, 518]] 1.0 6hvf Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3QLFA P00523 258 533 533.0 PD5:601 Type1 Inactive DFGin 6.5921 16.183 None -149.92, 159.8 50.0, 78.08 -122.59, 999.0 79.02, 81.05 999.0, 999.0 in-none in 8.3977 Saltbr-none 999.0 HRD-in -102.3, -42.82 78.63, -40.47 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.26 APE8-dihe-in -83.56, 51.53 APE8-rot-na 4.24 APE67-dihe-in -63.39, -20.05 -50.25, -42.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2539 L317I None None XRAY 2.75 0.194 0.232 A 286.0 249.0 27 29 11 18 [[267, 518]] 1.0 3qlf Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3EN6B P00523 257 533 533.0 KS5:2 Type1 Inactive DFGin 6.6504 14.6384 None -130.32, 170.59 65.82, 71.11 -81.33, 999.0 291.91, 78.68 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.22, -54.73 87.09, -19.17 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -66.83, -19.55 999.0, -46.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.213 0.259 B 286.0 239.0 38 29 9 20 [[267, 518]] 1.0 3en6 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3EN7A P00523 256 533 533.0 ABJ:1 Type1 Inactive DFGin 6.7993 15.2664 None -131.18, 170.04 64.66, 73.9 -88.47, 999.0 287.94, 72.41 999.0, 999.0 out-none out 13.7848 Saltbr-none 999.0 HRD-in -82.22, -58.5 95.78, -28.27 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -21.12 APE8-rot-na 351.27 APE67-dihe-in -57.98, -25.97 -49.58, -41.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.81 0.209 0.257 A 286.0 247.0 31 29 10 19 [[267, 518]] 1.0 3en7 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4O2PA P00523 257 533 533.0 11V:601 Type1 Inactive DFGin 8.0578 17.1298 None -95.66, -160.19 -77.69, 78.89 -69.16, -32.26 54.5, 90.73 -73.56, -52.84 out-out out 10.7609 Saltbr-out 10.6081 HRD-in -76.83, -53.36 83.38, -20.14 out-out-out SNCooo out-out ActLoopNT-out 8.4513 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.81 APE8-dihe-in -95.12, 54.12 APE8-rot-na 25.28 APE67-dihe-in -61.76, -23.02 -71.35, -22.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6916 None None None XRAY 2.1 0.197 0.238 A 286.0 265.0 12 29 19 10 [[267, 518]] 1.0 4o2p Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 7AH3A P00523 257 533 533.0 RCK:601 Type1 Inactive DFGin 8.0994 17.1269 None -94.42, -158.53 -86.4, 76.82 -66.07, -31.23 51.59, 90.68 -69.81, -45.01 out-out out 12.2802 Saltbr-out 10.2659 HRD-in -75.61, -58.33 82.34, -9.46 out-out-none SNCoon out-none ActLoopNT-out 8.1168 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.1 APE8-rot-na 27.59 APE67-dihe-in -71.32, -13.88 -41.24, -37.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.189 0.226 A 286.0 265.0 12 29 17 12 [[267, 518]] 1.0 7ah3 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 8K79B P00523 269 533 533.0 IYC:601 Type1 Inactive DFGin 6.2753 13.6162 None -142.02, -165.55 59.65, 45.03 -69.39, 999.0 318.36, 96.34 999.0, 999.0 in-none in 8.2431 Saltbr-none 999.0 HRD-in -103.64, -40.14 66.81, -6.75 none-out-none SNCnon out-none ActLoopNT-out 5.8068 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.54 APE8-dihe-in -62.36, 104.78 APE8-rot-na 18.14 APE67-dihe-in -67.37, -19.95 -65.33, -31.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.1361 None None None XRAY 2.8 0.248 0.277 B 286.0 244.0 23 29 13 16 [[267, 518]] 1.0 8k79 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4LGGA P00523 264 533 533.0 VGG:601 Type1 Inactive DFGin 7.4586 16.3093 None -143.99, -175.58 60.26, 55.48 -85.7, 999.0 279.81, 89.82 999.0, 999.0 in-in in 8.2763 Saltbr-in 2.7967 HRD-in -80.21, -55.45 83.98, 3.12 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 90.19 APE8-rot-na 335.43 APE67-dihe-in -64.84, -21.94 -59.75, -40.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338G None None XRAY 2.41 0.238 0.285 A 270.0 241.0 29 29 10 19 [[267, 518]] 1.0 4lgg Gallus gallus TYR_SRC_CHICK TYR 2.3e-93 318.2 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4LGGB P00523 264 533 533.0 VGG:601 Type1 Inactive DFGin 7.2053 15.9784 None -143.86, -173.8 55.54, 66.67 -91.46, 999.0 283.89, 82.38 999.0, 999.0 in-in in 8.3266 Saltbr-in 2.7174 HRD-in -83.08, -59.41 91.8, -22.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.8 APE8-rot-na 28.86 APE67-dihe-in -67.2, -17.89 -63.93, -34.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338G None None XRAY 2.41 0.238 0.285 B 270.0 245.0 25 29 10 19 [[267, 518]] 1.0 4lgg Gallus gallus TYR_SRC_CHICK TYR 2.3e-93 318.2 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2HWOB P00523 258 533 533.0 RBS:1345 Type1 Inactive DFGin 7.4463 16.7569 None -142.66, 177.84 48.56, 63.89 -65.19, 999.0 276.69, 83.46 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -98.03, -53.6 90.58, -24.9 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 52.78 APE8-rot-na 32.73 APE67-dihe-in -63.88, -24.33 -65.14, -25.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S345C None None XRAY 2.5 0.238 0.292 B 286.0 242.0 34 29 10 19 [[267, 518]] 1.0 2hwo Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2HWPA P00523 256 533 533.0 DJK:1345 Type1 Inactive DFGin 4.9448 11.4913 None -149.7, 174.68 63.8, 24.74 24.42, 999.0 327.73, 96.53 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -76.7, -56.82 88.65, -21.99 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.02 APE8-dihe-in -78.72, 120.33 APE8-rot-na 32.38 APE67-dihe-in -69.35, -32.46 -64.49, -21.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.5907 S345C None None XRAY 2.48 0.228 0.276 A 286.0 245.0 33 29 11 18 [[267, 518]] 1.0 2hwp Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4LGHA P00523 257 533 533.0 0JN:601 Type1 Inactive DFGin 6.9841 15.7897 None -153.73, -177.11 55.11, 69.07 -80.53, 999.0 289.05, 74.19 999.0, 999.0 in-out in 9.2031 Saltbr-out 10.922 HRD-out -100.29, 92.72 -56.91, -30.62 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.24 APE8-rot-na 31.99 APE67-dihe-in -69.83, -39.6 -61.27, -32.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338G None None XRAY 2.84 0.216 0.272 A 277.0 243.0 34 29 10 19 [[267, 518]] 1.0 4lgh Gallus gallus TYR_SRC_CHICK TYR 2.5e-93 318.0 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4LGHB P00523 259 533 533.0 0JN:601 Type1 Inactive DFGin 8.4608 17.0147 None -87.06, -150.22 -90.59, 77.55 -61.39, -5.78 49.04, 92.12 -122.47, 93.03 out-none out 12.5152 Saltbr-none 999.0 HRD-out -92.47, 101.6 -76.08, -4.72 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 4.95 APE8-rot-na 33.13 APE67-dihe-in -61.02, -21.67 -62.96, -38.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338G None None XRAY 2.84 0.216 0.272 B 277.0 247.0 28 29 12 17 [[267, 518]] 1.0 4lgh Gallus gallus TYR_SRC_CHICK TYR 2.5e-93 318.0 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4MCVB P00523 257 533 533.0 29K:601 Type1 Inactive DFGin 6.5779 14.5177 None -111.05, -91.71 -54.53, 101.39 -99.75, 24.59 297.04, 135.4 -66.22, -20.64 in-none in 8.6792 Saltbr-none 999.0 HRD-out -91.75, 94.41 -63.21, -28.33 none-in-out SNCnio in-out ActLoopNT-in 3.3836 ActLoopCT-out TYR APEdihe_noiai APEdist_aaao APE10-dihe-none 999.0, -64.72 APE9-dihe-out -78.76, -45.22 APE8-dihe-in -67.37, 93.43 APE8-rot-na 21.86 APE67-dihe-in -62.54, -30.51 -60.98, -34.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.2773 APE9-dist-out 8.2307 T338G None None XRAY 2.73 0.243 0.29 B 278.0 265.0 12 29 18 11 [[267, 518]] 1.0 4mcv Gallus gallus TYR_SRC_CHICK TYR 2.6e-93 318.0 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5T0PA P00523 257 533 533.0 73A:600 Type1 Inactive DFGin 4.3573 13.0469 None -108.06, -94.22 -78.77, 78.46 -95.95, 36.88 46.97, 79.53 -69.4, 116.82 in-out in 7.9811 Saltbr-out 4.0612 HRD-in -76.47, -49.02 77.78, -0.46 out-in-none SNCoin in-none ActLoopNT-in 3.0342 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.81 APE8-rot-na 33.7 APE67-dihe-in -60.65, -32.77 -54.16, -43.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V313C None None XRAY 2.5 0.267 0.323 A 286.0 264.0 13 29 16 13 [[267, 518]] 1.0 5t0p Gallus gallus TYR_SRC_CHICK TYR 4.9e-94 320.4 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5T0PB P00523 258 533 533.0 73A:600 Type1 Inactive DFGin 6.0347 13.9864 None -105.32, -89.98 -65.65, 94.02 -87.72, 23.24 309.83, 102.99 -75.54, -3.08 in-out in 7.89 Saltbr-out 4.0724 HRD-in -75.88, -49.59 76.61, 0.68 out-in-none SNCoin in-none ActLoopNT-in 3.0052 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 20.14 APE8-rot-na 33.29 APE67-dihe-in -60.74, -32.25 -53.16, -44.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V313C None None XRAY 2.5 0.267 0.323 B 286.0 263.0 13 29 16 13 [[267, 518]] 1.0 5t0p Gallus gallus TYR_SRC_CHICK TYR 4.9e-94 320.4 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2QLQA P00523 256 533 533.0 SR2:1345,SR2:1483 Type1,Allosteric Inactive DFGin 6.9884 15.8146 None -132.63, -179.88 43.58, 57.27 -47.86, 999.0 281.23, 68.03 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -89.12, -52.37 88.94, -22.71 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 101.84 APE8-rot-na 326.98 APE67-dihe-in -62.91, -20.52 -104.71, 0.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S345C None None XRAY 2.33 0.215 0.267 A 286.0 245.0 33 29 10 19 [[267, 518]] 1.0 2qlq Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5TEHA P00523 256 533 533.0 S56:600 Type1.5_Back Inactive DFGin 5.9639 13.5045 None -165.57, -155.39 40.26, 84.58 -84.9, -72.66 314.29, 99.49 -61.22, 999.0 out-out out 10.6204 Saltbr-out 5.2868 HRD-in -98.4, -39.03 82.49, -52.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.47 APE8-dihe-in -96.16, 52.27 APE8-rot-na 35.96 APE67-dihe-in -76.12, -20.57 -66.98, -13.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5237 V281C None None XRAY 2.99 0.307 0.366 A 286.0 261.0 17 29 12 17 [[267, 518]] 1.0 5teh Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3QLFB P00523 258 533 533.0 PD5:601 Type1.5_Front Inactive DFGin 6.1412 12.6014 None -150.33, 164.09 75.91, 111.22 -150.95, 999.0 2.54, 56.9 999.0, 999.0 out-none out 11.1152 Saltbr-none 999.0 HRD-in -102.4, -44.0 81.56, -46.14 none-in-out SNCnio in-out ActLoopNT-in 3.2215 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -83.83, 51.78 APE8-rot-na 4.43 APE67-dihe-in -63.43, -19.12 -50.83, -42.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2932 L317I None None XRAY 2.75 0.194 0.232 B 286.0 258.0 18 29 13 16 [[267, 518]] 1.0 3qlf Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC GRK2 ARBK1_HUMAN 3CIKA P25098 29 669 689.0 No_ligand No_ligand Inactive DFGin 5.2003 12.94 None -113.38, -84.39 -77.41, 106.5 -85.28, 5.55 272.59, 132.44 -54.41, -34.31 in-in in 8.589 Saltbr-in 2.8304 HRD-in -65.15, -43.87 69.81, -16.37 in-in-in SNCiii in-in ActLoopNT-in 2.8246 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.98, 126.35 APE9-dihe-na 141.75, -159.25 APE8-dihe-in -111.86, 146.5 APE8-rot-in 310.14 APE67-dihe-in -81.13, 3.2 -68.81, -30.14 APE12-dist-in 10.9775 APE11-dist-in 12.0726 APE10-dist-in 6.4171 APE9-dist-in 3.5873 None None None XRAY 2.75 0.208 0.269 A 689.0 619.0 0 26 26 0 [[191, 453]] 1.0 3cik Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 7PWDA P25098 27 668 689.0 8DS:701 Type1 Inactive DFGin 5.2813 12.9593 None -103.27, -91.53 -83.38, 120.45 -98.95, 11.01 295.2, 164.91 -62.17, -28.84 in-in in 8.7988 Saltbr-in 2.8227 HRD-in -68.27, -51.69 76.81, -22.19 in-in-in SNCiii in-in ActLoopNT-in 2.8256 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.66, 145.62 APE9-dihe-na 123.25, -162.48 APE8-dihe-in -110.04, 138.42 APE8-rot-in 305.66 APE67-dihe-inflip 98.02, -22.76 -65.28, 137.62 APE12-dist-in 10.312 APE11-dist-in 11.9263 APE10-dist-in 6.0194 APE9-dist-in 3.3652 S670A None None XRAY 2.6 0.192 0.23 A 697.0 621.0 0 26 26 0 [[191, 453]] 1.0 7pwd Homo sapiens AGC_GRK2_HUMAN AGC 6.4e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3KRWA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.4431 12.512 None -124.43, -69.99 -70.72, 103.06 -103.15, 18.82 281.61, 154.56 -63.74, -46.79 in-in in 8.9073 Saltbr-in 2.6208 HRD-in -80.35, -50.37 71.38, -3.06 in-in-in SNCiii in-in ActLoopNT-in 2.7506 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.68, 135.05 APE9-dihe-na 136.51, -178.33 APE8-dihe-in -97.44, 143.34 APE8-rot-in 311.93 APE67-dihe-in -81.84, -17.98 -65.75, -16.48 APE12-dist-in 9.7737 APE11-dist-in 11.7182 APE10-dist-in 5.7635 APE9-dist-in 3.2649 None None None XRAY 2.9 0.216 0.265 A 688.0 618.0 0 26 26 0 [[191, 453]] 1.0 3krw Homo sapiens AGC_GRK2_HUMAN AGC 6.2e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3KRXA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.4192 12.8449 None -125.39, -77.94 -69.67, 105.65 -105.64, 33.0 281.38, 161.16 -76.22, -41.07 in-in in 9.1809 Saltbr-in 2.9453 HRD-in -81.43, -47.09 70.32, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.7468 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.75, 134.45 APE9-dihe-na 144.08, -171.31 APE8-dihe-in -102.11, 138.21 APE8-rot-in 300.04 APE67-dihe-in -91.64, -15.37 -61.65, -13.24 APE12-dist-in 9.2638 APE11-dist-in 11.5714 APE10-dist-in 5.62 APE9-dist-in 3.2776 None None None XRAY 3.1 0.232 0.27 A 688.0 618.0 0 26 26 0 [[191, 453]] 1.0 3krx Homo sapiens AGC_GRK2_HUMAN AGC 6.2e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK5 GRK5_HUMAN 6PJXA P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.2367 11.8767 None -101.92, -82.66 -75.73, 114.06 -96.27, 14.0 297.14, 3.15 -60.02, -23.28 in-in in 8.7999 Saltbr-in 2.3601 HRD-in -81.73, -51.04 76.16, -8.97 in-in-in SNCiii in-in ActLoopNT-in 2.8132 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.38, 158.39 APE9-dihe-na 127.63, -164.44 APE8-dihe-in -112.45, 140.59 APE8-rot-in 303.57 APE67-dihe-inflip 81.94, -9.46 -52.3, 137.55 APE12-dist-in 9.8463 APE11-dist-in 11.9422 APE10-dist-in 6.1145 APE9-dist-in 4.4639 E104K,R304H,G438E None None XRAY 1.96 0.197 0.23 A 591.0 542.0 0 27 27 0 [[186, 448]] 1.0 6pjx Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.0198 12.8412 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.3335 Saltbr-in 3.3688 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.0372 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.1019 APE10-dist-in 6.3064 APE9-dist-in 4.1737 D311N None None XRAY 2.8 0.232 0.277 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 8uaq Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRFA P34947 25 542 590.0 A1AQ5:601 Type1 Inactive DFGin 6.2131 12.8852 None -116.13, -75.08 -76.38, 97.42 -93.08, 20.96 275.91, 78.29 -67.65, -17.42 in-in in 9.0758 Saltbr-in 2.4746 HRD-in -89.29, -49.76 68.56, 5.65 in-in-in SNCiii in-in ActLoopNT-in 3.0583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.67, 152.28 APE9-dihe-na 135.63, -159.61 APE8-dihe-in -113.28, 137.14 APE8-rot-in 304.0 APE67-dihe-inflip 86.51, -10.19 -50.9, 134.51 APE12-dist-in 9.9844 APE11-dist-in 12.0653 APE10-dist-in 6.2254 APE9-dist-in 4.1192 D311N None None XRAY 2.84 0.224 0.277 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brf Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRIA P34947 25 542 590.0 A1AQ8:601 Type1 Inactive DFGin 5.7901 12.7141 None -118.56, -79.42 -70.93, 91.99 -85.99, 18.72 271.5, 67.77 -66.54, -25.08 in-in in 8.8021 Saltbr-in 2.6488 HRD-in -85.77, -46.41 67.52, 4.46 in-in-in SNCiii in-in ActLoopNT-in 3.1673 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.68, 145.74 APE9-dihe-na 145.19, -146.92 APE8-dihe-in -122.56, 141.77 APE8-rot-in 306.39 APE67-dihe-inflip 92.75, -9.14 -56.37, 130.7 APE12-dist-in 10.1331 APE11-dist-in 12.2149 APE10-dist-in 6.5714 APE9-dist-in 4.2246 D311N None None XRAY 2.9 0.217 0.26 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bri Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRJA P34947 25 542 590.0 A1AQ9:601 Type1 Inactive DFGin 5.7352 12.6187 None -115.77, -57.96 -84.12, 93.88 -92.94, 12.58 279.31, 72.41 -59.97, -23.3 in-in in 9.0567 Saltbr-in 2.377 HRD-in -83.8, -57.51 72.28, 3.71 in-in-in SNCiii in-in ActLoopNT-in 3.1163 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.79, 160.14 APE9-dihe-na 133.68, -150.07 APE8-dihe-in -119.54, 137.2 APE8-rot-in 310.18 APE67-dihe-inflip 98.77, -19.66 -54.34, 129.82 APE12-dist-in 9.7235 APE11-dist-in 12.1088 APE10-dist-in 6.4144 APE9-dist-in 4.1673 D311N None None XRAY 2.8 0.239 0.273 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brj Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PRKCB KPCB_HUMAN 9S9TA P05771 340 667 671.0 LY4:60701 Type1 Inactive DFGin 6.0927 13.9734 None -111.78, -89.62 -67.76, 129.93 -115.94, 12.83 282.89, 115.63 -69.35, -46.77 in-in in 8.5218 Saltbr-in 2.7226 HRD-in -57.71, -56.78 85.18, -40.4 in-in-in SNCiii in-in ActLoopNT-in 3.456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.66, 131.78 APE9-dihe-na 176.22, -177.75 APE8-dihe-in -90.0, 133.29 APE8-rot-in 321.38 APE67-dihe-in -84.35, -33.13 -46.48, -38.11 APE12-dist-in 8.3134 APE11-dist-in 11.686 APE10-dist-in 5.7522 APE9-dist-in 4.3402 D427N TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.425 0.218 0.29 A 353.0 315.0 0 28 28 0 [[342, 600]] 1.0 9s9t Homo sapiens AGC_PRKCB_HUMAN AGC 1.3e-97 332.0 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC ROCK1 ROCK1_HUMAN 3TWJC Q13464 7 402 1354.0 07R:2 Type1 Inactive DFGin 8.7595 16.2726 None -145.99, 165.67 60.97, 69.02 -57.54, -10.47 212.34, 59.8 -68.93, 18.62 in-out in 7.7943 Saltbr-out 3.8223 HRD-in -73.44, -64.4 76.54, -16.94 out-out-out SNCooo out-out ActLoopNT-out 3.6487 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oiio APE10-dihe-na -174.55, 155.89 APE9-dihe-na -163.77, 151.18 APE8-dihe-out 67.81, 65.3 APE8-rot-in 318.87 APE67-dihe-in -61.73, -42.12 -68.66, -9.31 APE12-dist-out 6.7625 APE11-dist-in 8.2184 APE10-dist-in 6.2456 APE9-dist-out 9.0493 None None None XRAY 2.9 0.224 0.289 C 410.0 396.0 0 29 29 0 [[76, 338]] 1.0 3twj Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1.0 260.0 260.0 215 216 217 219 221 105 124 128 195 197 196 198.0 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 5U7RD O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.9914 13.6381 None -137.02, -44.53 -96.66, 83.52 -88.69, 16.85 303.92, 107.42 -55.18, -36.04 in-in in 8.7331 Saltbr-in 2.7396 HRD-in -81.59, -27.48 68.65, -73.51 in-in-out SNCiio in-out ActLoopNT-in 3.0332 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -137.68 APE8-dihe-in -113.15, 136.27 APE8-rot-out 64.84 APE67-dihe-in -28.57, -52.13 -70.74, -29.02 APE12-dist-out 6.8435 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7119 None None None XRAY 3.33 0.202 0.241 D 395.0 382.0 5 29 27 2 [[92, 354]] 1.0 5u7r Homo sapiens AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA P51812 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.6399 11.2827 None -75.51, -9.72 -147.12, 169.74 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.1812 APE11-dist-out 18.8341 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317.0 295.0 9 28 26 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.8283 11.217 None -75.62, -9.94 -146.57, 168.73 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.1321 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.6928 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317.0 293.0 10 28 26 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.7417 11.3154 None -74.55, -8.16 -143.05, 166.95 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.2243 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.6879 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317.0 292.0 11 28 25 3 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.7434 11.0548 None -76.12, -10.81 -146.65, 168.53 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.9521 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.1175 APE11-dist-out 17.3774 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317.0 293.0 10 28 26 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.9835 11.2516 None -84.57, 1.64 -160.36, 173.95 -140.73, 41.08 33.77, 88.9 86.89, 20.77 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.55, -32.96 78.36, -52.1 none-out-out SNCnoo out-out ActLoopNT-out 9.9576 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.72, -148.34 APE9-dihe-na -103.74, -158.66 APE8-dihe-in -91.11, 113.9 APE8-rot-in 297.76 APE67-dihe-in -53.19, -20.32 -55.54, -41.19 APE12-dist-in 13.7321 APE11-dist-out 15.8714 APE10-dist-out 13.5037 APE9-dist-in 5.5319 None None None XRAY 2.499 0.188 0.233 A 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g77 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.612 11.3114 None -84.74, -2.79 -145.41, 176.89 -143.69, 39.64 45.89, 82.52 94.84, 15.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.95, -30.79 74.87, -47.1 none-out-out SNCnoo out-out ActLoopNT-out 10.0706 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.75, -144.28 APE9-dihe-na -119.2, -153.74 APE8-dihe-in -83.74, 120.03 APE8-rot-in 297.54 APE67-dihe-in -52.98, -34.42 -57.71, -42.71 APE12-dist-in 13.9149 APE11-dist-out 16.0857 APE10-dist-out 13.633 APE9-dist-in 5.5223 None None None XRAY 2.499 0.188 0.233 B 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g77 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KB1 KS6B1_HUMAN 4RLOA P23443 85 371 525.0 3T3:401 Type1 Inactive DFGin 5.2698 12.7473 None -131.54, -63.42 -88.2, 143.06 -127.47, 172.78 303.39, 172.08 126.01, -46.31 in-in in 7.6982 Saltbr-in 2.3003 HRD-in -57.89, -55.64 79.38, -25.61 in-in-out SNCiio in-out ActLoopNT-in 3.2859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.78 APE8-dihe-in -54.68, 162.27 APE8-rot-out 190.34 APE67-dihe-in -62.73, -12.73 -141.73, -3.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 30.2221 None None None XRAY 2.527 0.193 0.222 A 288.0 259.0 28 28 16 12 [[91, 352]] 1.0 4rlo Homo sapiens AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A P23443 85 371 525.0 STU:400 Type1 Inactive DFGin 6.1574 13.694 None -106.91, -67.93 -78.35, 124.27 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.7541 Saltbr-out 3.9045 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327.0 263.0 24 28 15 13 [[91, 352]] 1.0 3a60 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A P23443 87 371 525.0 STU:400 Type1 Inactive DFGin 5.8125 13.4055 None -134.05, -75.4 -81.48, 111.28 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.8631 Saltbr-in 3.4595 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9635 None None None XRAY 3.43 0.274 0.349 A 327.0 254.0 31 28 12 16 [[91, 352]] 1.0 3a61 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WF7A P23443 83 374 525.0 FS9:402 Type1 Inactive DFGin 6.6625 14.9899 None -128.93, -10.26 -99.96, 98.47 -129.8, 160.96 298.66, 90.56 73.54, -129.51 out-out out 14.17 Saltbr-out 10.1405 HRD-in -80.11, -34.14 77.1, -48.65 out-out-out SNCooo out-out ActLoopNT-out 12.9719 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -70.88, 130.47 APE9-dihe-na 74.33, -175.83 APE8-dihe-in -68.5, 140.34 APE8-rot-out 182.72 APE67-dihe-in -64.92, -16.71 -105.43, 9.18 APE12-dist-in 11.9606 APE11-dist-out 14.4376 APE10-dist-out 10.0149 APE9-dist-out 11.9861 None TPO252 TPO252 XRAY 1.85 0.175 0.224 A 329.0 289.0 3 28 25 3 [[91, 352]] 1.0 3wf7 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC STK38 STK38_HUMAN 6BXIA Q15208 82 414 465.0 ANP:501 ATPlike Inactive DFGin 7.6243 15.2423 None -66.11, 165.54 -58.06, 132.91 -140.43, 160.91 66.01, 93.84 127.58, -39.07 out-out out 17.2238 Saltbr-out 15.8035 HRD-out -81.74, 95.52 -90.45, 26.47 out-out-out SNCooo out-out ActLoopNT-out 8.4633 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.6, -60.62 APE9-dihe-na 67.05, -156.06 APE8-dihe-in -145.17, 163.6 APE8-rot-out 65.89 APE67-dihe-in -50.28, -35.19 -91.75, 25.88 APE12-dist-out 17.3379 APE11-dist-out 14.2084 APE10-dist-out 17.7703 APE9-dist-out 12.1009 None None None XRAY 2.2 0.173 0.212 A 333.0 333.0 0 63 63 0 [[89, 382]] 1.0 6bxi Homo sapiens AGC_STK38_HUMAN AGC 2.8e-98 334.1 1.0 260.0 260.0 229 230 231 233 235 118 137 141 209 211 210 212.0 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB Q15208 83 414 465.0 ANP:501 ATPlike Inactive DFGin 7.5828 15.1791 None -72.08, 165.13 -53.35, 130.13 -138.87, 159.98 66.77, 96.29 126.01, -39.3 out-out out 17.1655 Saltbr-out 16.0645 HRD-out -84.3, 107.68 -100.32, 27.31 out-out-out SNCooo out-out ActLoopNT-out 8.4877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.07, -63.08 APE9-dihe-na 73.07, -157.98 APE8-dihe-in -144.12, 160.82 APE8-rot-out 65.98 APE67-dihe-in -53.15, -35.39 -88.29, 27.93 APE12-dist-out 17.2389 APE11-dist-out 14.1835 APE10-dist-out 17.7413 APE9-dist-out 12.0524 None None None XRAY 2.2 0.173 0.212 B 333.0 332.0 0 63 63 0 [[89, 382]] 1.0 6bxi Homo sapiens AGC_STK38_HUMAN AGC 2.8e-98 334.1 1.0 260.0 260.0 229 230 231 233 235 118 137 141 209 211 210 212.0 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
CAMK AURKA AURKA_HUMAN 4C3PA O14965 125 388 403.0 ACP:1389 ATPlike Inactive DFGin 5.1209 15.3112 None -143.16, 44.14 -117.33, -72.7 63.16, 22.36 309.54, 103.5 -71.05, -27.42 out-out out 10.7129 Saltbr-out 4.9547 HRD-out -79.39, 150.41 -121.39, -68.05 out-in-out SNCoio in-out ActLoopNT-in 2.8189 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -49.34, 122.38 APE9-dihe-na 116.03, -35.9 APE8-dihe-out -100.65, -0.54 APE8-rot-out 177.69 APE67-dihe-in -57.5, -32.82 -45.19, -41.29 APE12-dist-out 20.9276 APE11-dist-out 21.1759 APE10-dist-out 26.1561 APE9-dist-out 28.5914 None None None XRAY 2.69 0.205 0.289 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 4c3p Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6DA O14965 126 390 403.0 ANP:61391 ATPlike Inactive DFGin 6.2574 16.4224 None -70.12, 150.14 -40.51, 101.21 -55.1, 131.85 61.77, 102.87 98.63, -164.78 out-out out 13.1601 Saltbr-out 13.9978 HRD-out -91.98, 166.93 -128.47, 87.17 out-out-out SNCooo out-out ActLoopNT-out 17.9333 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.8 APE8-dihe-in -71.63, 167.98 APE8-rot-out 60.54 APE67-dihe-in -57.74, -18.95 -51.64, -36.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0437 None None None XRAY 2.2 0.23 0.28 A 275.0 255.0 10 26 16 10 [[133, 383]] 1.0 2c6d Homo sapiens CAMK_AURKA_HUMAN CAMK 1.5e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ODTA O14965 126 392 403.0 ADP:501 ATPlike Inactive DFGin 6.7171 16.9598 None -121.13, 4.47 -111.78, 32.81 -79.52, 164.76 286.94, 96.78 78.48, -128.28 out-out out 11.7478 Saltbr-out 10.767 HRD-out -137.93, 83.59 -73.55, -34.72 out-out-out SNCooo out-out ActLoopNT-out 17.7885 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -15.28 APE9-dihe-na -98.55, 177.35 APE8-dihe-out 65.78, -46.63 APE8-rot-none 999.0 APE67-dihe-in -47.55, -29.4 -45.89, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.8668 APE9-dist-out 13.4366 D274N,C290A,C393A None None XRAY 2.021 0.179 0.211 A 283.0 258.0 9 26 17 9 [[133, 383]] 1.0 5odt Homo sapiens CAMK_AURKA_HUMAN CAMK 5.4e-78 267.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBJA O14965 127 390 403.0 ATP:404,9QK:405 ATPlike,Allosteric Inactive DFGin 6.016 15.9671 None -127.31, -156.34 57.9, -96.92 69.6, 25.6 277.68, 99.91 -74.82, -34.09 out-out out 10.8688 Saltbr-out 3.9746 HRD-in -84.35, -43.15 67.43, 1.86 out-in-out SNCoio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -85.06 APE9-dihe-na -106.73, -153.17 APE8-dihe-in -86.88, 144.13 APE8-rot-in 279.73 APE67-dihe-in -52.07, -35.29 -66.02, -11.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3791 APE9-dist-out 10.1992 None None None XRAY 2.901 0.215 0.245 A 272.0 260.0 4 26 22 4 [[133, 383]] 1.0 5obj Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.1772 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.8811 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7077 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285.0 256.0 12 26 14 12 [[133, 383]] 1.0 9guc Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8JF4A O14965 127 389 403.0 C0N:401 Type1 Inactive DFGin 7.2529 17.8729 None -135.45, -161.79 63.9, -97.55 64.54, 6.09 245.37, 117.13 -63.89, -23.61 out-none out 12.6402 Saltbr-none 999.0 HRD-out -120.1, 149.54 -137.31, -168.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -130.74 APE9-dihe-na -95.79, -164.69 APE8-dihe-in -61.45, 121.57 APE8-rot-in 284.06 APE67-dihe-in -41.63, -35.05 -74.97, -8.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.8848 APE9-dist-out 12.0317 None None None XRAY 2.893 0.241 0.3 A 263.0 252.0 11 26 15 11 [[133, 383]] 1.0 8jf4 Homo sapiens CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8JMXA O14965 127 389 403.0 E47:401 Type1 Inactive DFGin 8.1479 17.9382 None -66.97, -135.61 -86.55, 178.72 -114.61, 4.13 278.35, 26.61 128.02, 999.0 out-none out 12.4603 Saltbr-none 999.0 HRD-out -175.92, -143.93 -146.96, -121.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, -148.55 APE9-dihe-na -86.45, -174.61 APE8-dihe-out -81.39, -14.34 APE8-rot-out 176.74 APE67-dihe-out -64.27, -11.38 79.63, -40.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3418 None None None XRAY 2.95 0.231 0.306 A 263.0 250.0 13 26 13 13 [[133, 383]] 1.0 8jmx Homo sapiens CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7AYIA O14965 125 392 403.0 S9K:501 Type1 Inactive DFGin 5.4193 15.6223 None -144.41, -177.78 68.28, 27.25 -31.37, 999.0 286.89, 77.45 999.0, 999.0 out-out out 11.6263 Saltbr-out 5.2735 HRD-out -134.3, 170.16 -127.02, -53.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -25.37 APE8-rot-out 50.94 APE67-dihe-in -37.9, -35.61 -58.22, -27.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.254 0.297 A 285.0 252.0 16 26 10 16 [[133, 383]] 1.0 7ayi Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J4ZB O14965 126 395 403.0 626:1395 Type1 Inactive DFGin 4.2178 13.6848 None -135.88, 74.16 -114.29, 33.41 -89.42, 114.89 302.17, 82.01 -8.53, 159.28 out-out out 11.4154 Saltbr-out 7.1624 HRD-out 58.44, 64.77 -95.37, 159.29 out-out-out SNCooo out-out ActLoopNT-out 18.7148 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -94.91, -9.28 APE9-dihe-na 130.48, -157.55 APE8-dihe-in -66.91, 118.34 APE8-rot-in 305.65 APE67-dihe-in -61.18, -13.87 -47.83, -58.47 APE12-dist-out 16.9419 APE11-dist-out 16.0005 APE10-dist-out 16.5324 APE9-dist-out 8.9625 None None None XRAY 2.0 0.214 0.249 B 306.0 270.0 0 26 26 0 [[133, 383]] 1.0 2j4z Homo sapiens CAMK_AURKA_HUMAN CAMK 9.9e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0WA O14965 125 391 403.0 ADN:501 Type1 Inactive DFGin 6.2719 16.5981 None -99.25, -54.63 -80.04, -74.28 72.86, -1.54 279.35, 93.09 -53.76, -20.49 out-out out 11.3192 Saltbr-out 4.9936 HRD-in -77.36, -61.61 76.79, -35.67 out-in-out SNCoio in-out ActLoopNT-in 2.7811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -96.78, 99.9 APE9-dihe-na 173.74, 169.14 APE8-dihe-in -81.74, 143.07 APE8-rot-out 200.15 APE67-dihe-in -47.45, -41.6 -91.34, -9.3 APE12-dist-none 999.0 APE11-dist-in 12.2482 APE10-dist-out 14.98 APE9-dist-out 11.7548 H254Y None None XRAY 2.6 0.246 0.277 A 282.0 259.0 8 26 18 8 [[133, 383]] 1.0 4o0w Homo sapiens CAMK_AURKA_HUMAN CAMK 1.5e-78 269.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H0ZA O14965 128 388 403.0 45B:1 Type1 Inactive DFGin 7.3472 16.083 None -89.96, 161.55 64.52, -172.92 -163.13, -57.24 280.93, 123.29 171.24, 120.64 out-out out 10.3185 Saltbr-out 7.3796 HRD-out -71.52, 144.0 -92.02, -55.66 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.34 APE8-rot-out 164.31 APE67-dihe-in -55.12, -32.9 -104.49, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.92 0.221 0.286 A 268.0 248.0 13 26 13 13 [[133, 383]] 1.0 3h0z Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DHFA O14965 128 389 403.0 0K6:401 Type1 Inactive DFGin 6.0606 15.9561 None -124.92, -165.4 70.7, -102.39 69.61, 140.83 290.26, 89.34 63.95, 95.41 in-in in 8.9889 Saltbr-in 2.893 HRD-in -73.28, -47.83 72.66, -2.67 in-in-out SNCiio in-out ActLoopNT-in 3.5586 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -6.14 APE9-dihe-na -59.01, 54.1 APE8-dihe-out 19.82, 17.91 APE8-rot-out 105.73 APE67-dihe-out -28.21, -43.1 61.5, -49.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7292 APE9-dist-out 7.9962 T287D,T288D None None XRAY 2.8 0.21 0.299 A 271.0 258.0 4 26 22 4 [[133, 383]] 1.0 4dhf Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DHFB O14965 128 389 403.0 0K6:401 Type1 Inactive DFGin 6.2133 16.1482 None -129.3, -166.63 71.78, -102.87 78.31, 163.45 277.6, 93.12 43.8, 85.35 in-in in 9.3755 Saltbr-in 3.1006 HRD-in -78.27, -44.01 67.72, -6.17 in-in-out SNCiio in-out ActLoopNT-in 2.9195 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -62.03 APE9-dihe-na -175.18, -54.66 APE8-dihe-out 61.81, -74.57 APE8-rot-out 81.7 APE67-dihe-out -53.34, -26.37 96.06, -28.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.9693 APE9-dist-out 10.0958 T287D,T288D None None XRAY 2.8 0.21 0.299 B 271.0 258.0 4 26 22 4 [[133, 383]] 1.0 4dhf Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4PRJA O14965 125 388 403.0 2VU:401 Type1 Inactive DFGin 5.9517 15.2568 None -87.9, -78.85 -67.3, 132.08 -130.02, 25.75 273.54, 81.31 -60.0, -22.81 in-in in 9.9032 Saltbr-in 3.107 HRD-in -70.35, -53.13 72.43, -26.65 in-in-out SNCiio in-out ActLoopNT-in 3.0892 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 60.06 APE9-dihe-na -85.89, -100.42 APE8-dihe-in -76.32, 127.81 APE8-rot-out 186.15 APE67-dihe-out -49.54, 145.49 -72.25, -20.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5199 APE9-dist-out 11.3043 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None None XRAY 2.8 0.233 0.275 A 269.0 251.0 13 26 16 10 [[133, 383]] 1.0 4prj Homo sapiens CAMK_AURKA_HUMAN CAMK 6.9e-79 270.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5AAEA O14965 126 388 403.0 7HD:1389 Type1 Inactive DFGin 5.9398 15.1503 None -95.89, -104.86 -82.25, 148.83 -122.78, 23.14 291.0, 74.49 -53.63, -36.45 out-none out 10.8697 Saltbr-none 999.0 HRD-in -83.0, -21.45 60.1, -65.55 none-in-out SNCnio in-out ActLoopNT-in 3.0061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -177.84 APE8-dihe-in -88.91, 121.07 APE8-rot-out 73.44 APE67-dihe-in -49.15, -25.21 -87.19, -36.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0803 C290A,C393A None None XRAY 3.11 0.241 0.291 A 285.0 252.0 11 26 15 11 [[133, 383]] 1.0 5aae Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0UA O14965 126 391 403.0 ADN:501 Type1 Inactive DFGin 6.2642 11.4304 None -100.67, -17.12 -134.58, 129.02 -80.64, -37.58 28.72, 51.86 64.49, -126.4 out-out out 12.2241 Saltbr-out 10.2319 HRD-out -138.46, 154.69 -78.12, -46.1 out-in-out SNCoio in-out ActLoopNT-in 3.5193 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.11, -47.49 APE9-dihe-na -96.12, 155.1 APE8-dihe-in -73.36, 140.7 APE8-rot-out 180.88 APE67-dihe-in -47.54, -36.76 -84.86, -11.52 APE12-dist-out 18.1413 APE11-dist-out 15.8917 APE10-dist-out 13.345 APE9-dist-out 11.2984 H254R None None XRAY 2.6 0.236 0.273 A 282.0 259.0 7 26 19 7 [[133, 383]] 1.0 4o0u Homo sapiens CAMK_AURKA_HUMAN CAMK 3.5e-78 268.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDA O14965 127 388 403.0 QMN:1389 Type1.5_Front Inactive DFGin 4.7703 14.7373 None -129.81, 37.03 -50.55, -31.01 -53.57, 125.59 325.32, 89.96 118.13, 999.0 out-out out 11.6146 Saltbr-out 8.8418 HRD-out 53.57, 64.67 -94.14, 134.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -65.57, -29.93 APE9-dihe-na 142.25, -148.89 APE8-dihe-in -77.46, 105.91 APE8-rot-in 292.33 APE67-dihe-in -60.25, -12.9 -39.34, -60.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.5975 None None None XRAY 3.2 0.215 0.262 A 287.0 254.0 8 26 18 8 [[133, 383]] 1.0 4uzd Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDB O14965 125 389 403.0 QMN:1390 Type1.5_Front Inactive DFGin 4.5757 14.7196 None -129.5, 39.33 -48.31, -42.14 -43.39, 138.93 326.34, 95.13 97.81, -168.36 out-out out 11.585 Saltbr-out 9.3972 HRD-out 50.88, 59.12 -92.12, 140.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.7, -29.88 APE9-dihe-na 143.96, -147.24 APE8-dihe-in -77.35, 106.49 APE8-rot-in 291.41 APE67-dihe-in -62.64, -12.41 -49.18, -49.73 APE12-dist-out 16.5866 APE11-dist-out 15.4049 APE10-dist-out 16.5271 APE9-dist-out 9.5026 None None None XRAY 3.2 0.215 0.262 B 287.0 258.0 7 26 19 7 [[133, 383]] 1.0 4uzd Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UYNA O14965 125 391 403.0 Y3M:1392 Type1.5_Front Inactive DFGin 4.6948 14.0105 None -129.71, 33.27 -11.88, -124.06 104.64, 86.61 36.8, 56.54 29.97, 999.0 out-out out 11.4313 Saltbr-out 9.4418 HRD-out 56.55, 66.12 -91.27, 149.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.31, -27.51 999.0, -36.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.201 0.234 A 287.0 249.0 18 26 10 16 [[133, 383]] 1.0 4uyn Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK1D KCC1D_HUMAN 6QP5A Q8IU85 13 302 385.0 No_ligand No_ligand Inactive DFGin 6.6925 11.1697 None -82.96, -28.34 -164.68, 155.1 -154.96, 145.85 57.53, 95.92 -69.69, 999.0 out-out out 13.9124 Saltbr-out 9.5859 HRD-in -71.62, -51.72 69.89, 0.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.85, -19.27 999.0, -54.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.194 0.227 A 322.0 266.0 24 27 10 17 [[23, 279]] 1.0 6qp5 Homo sapiens CAMK_CAMK1D_HUMAN CAMK 1.9e-99 338.2 1.0 256.0 256.0 164 165 166 168 170 52 69 73 141 143 142 144.0 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T28AAA Q8IU85 12 302 385.0 M92:407 Type1 Inactive DFGin 6.5698 11.3307 None -90.4, -16.76 -161.18, 147.37 -157.44, 158.53 66.3, 87.4 -95.47, 145.18 out-out out 13.7626 Saltbr-out 10.1987 HRD-in -66.33, -53.1 75.23, -5.6 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.8, -20.73 999.0, -50.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.55 0.159 0.183 AAA 385.0 271.0 20 27 11 16 [[23, 279]] 1.0 6t28 Homo sapiens CAMK_CAMK1D_HUMAN CAMK 3.3e-99 337.4 1.0 256.0 256.0 164 165 166 168 170 52 69 73 141 143 142 144.0 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 8BFSA Q8IU85 12 302 385.0 QNR:402 Type1 Inactive DFGin 6.6093 11.2575 None -91.07, -14.07 -169.4, 138.32 -147.41, 155.24 57.99, 100.54 -87.18, 999.0 out-out out 13.8364 Saltbr-out 10.5309 HRD-in -62.95, -53.35 75.46, -6.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.41, -10.62 999.0, -62.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.168 0.202 A 385.0 274.0 17 27 10 17 [[23, 279]] 1.0 8bfs Homo sapiens CAMK_CAMK1D_HUMAN CAMK 3.3e-99 337.4 1.0 256.0 256.0 164 165 166 168 170 52 69 73 141 143 142 144.0 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 8BFMA Q8IU85 12 301 385.0 QI6:403,QI6:404 Type1,Type3 Inactive DFGin 8.5628 12.6287 None -103.99, -11.66 -163.82, 149.21 -127.97, 160.23 291.25, 61.5 -121.89, 999.0 out-none out 12.8717 Saltbr-none 999.0 HRD-in -69.53, -51.54 74.1, -4.57 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -54.11 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.201 0.224 A 385.0 265.0 25 27 9 18 [[23, 279]] 1.0 8bfm Homo sapiens CAMK_CAMK1D_HUMAN CAMK 3.3e-99 337.4 1.0 256.0 256.0 164 165 166 168 170 52 69 73 141 143 142 144.0 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1G KCC1G_HUMAN 2JAMA Q96NX5 18 302 476.0 J60:61305 Type1 Inactive DFGin 6.5403 11.2135 None -126.22, -80.87 -87.21, 120.33 -158.04, 166.34 60.61, 89.98 86.24, -162.04 out-out out 12.3632 Saltbr-out 7.0937 HRD-out -65.72, -48.99 75.81, 136.04 out-out-out SNCooo out-out ActLoopNT-out 7.3145 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -125.89, 7.58 APE9-dihe-na 74.8, 27.03 APE8-dihe-in -122.46, 113.05 APE8-rot-out 60.16 APE67-dihe-inflip 103.53, 4.1 -79.6, 161.99 APE12-dist-out 17.4469 APE11-dist-out 19.3036 APE10-dist-out 17.0526 APE9-dist-out 17.1197 None None None XRAY 1.7 0.157 0.231 A 304.0 279.0 7 26 25 1 [[23, 277]] 1.0 2jam Homo sapiens CAMK_CAMK1G_HUMAN CAMK 7e-95 323.2 2.0 256.0 255.0 163 164 165 167 169 52 68 72 140 142 141 143.0 201 189 184 183 182 181 180 179 178 98 Calcium/calmodulin-dependent protein kinase type 1G
CAMK CAMK1G KCC1G_HUMAN 2JAMB Q96NX5 16 301 476.0 J60:61305 Type1 Inactive DFGin 6.6771 11.1321 None -124.15, -81.0 -87.53, 122.59 -160.87, 165.0 62.22, 92.45 89.73, -167.15 out-out out 12.3898 Saltbr-out 7.1065 HRD-out -61.63, -52.62 77.62, 132.57 out-out-out SNCooo out-out ActLoopNT-out 7.2194 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -119.46, -1.64 APE9-dihe-na 72.11, 27.97 APE8-dihe-in -123.57, 111.56 APE8-rot-out 56.49 APE67-dihe-inflip 101.49, 1.14 -80.93, 163.71 APE12-dist-out 17.5476 APE11-dist-out 19.4414 APE10-dist-out 16.8632 APE9-dist-out 17.0823 None None None XRAY 1.7 0.157 0.231 B 304.0 280.0 7 26 25 1 [[23, 277]] 1.0 2jam Homo sapiens CAMK_CAMK1G_HUMAN CAMK 7e-95 323.2 2.0 256.0 255.0 163 164 165 167 169 52 68 72 140 142 141 143.0 201 189 184 183 182 181 180 179 178 98 Calcium/calmodulin-dependent protein kinase type 1G
CAMK CHEK2 CHK2_HUMAN 3I6UB O96017 89 501 543.0 No_ligand No_ligand Inactive DFGin 6.1563 12.4796 None -142.78, 168.99 70.83, 76.16 -115.43, 999.0 26.14, 78.04 999.0, 999.0 out-none out 13.9532 Saltbr-none 999.0 HRD-in -61.77, -58.18 77.91, -11.36 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -48.92, -23.0 999.0, -21.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.0 0.247 0.28 B 419.0 376.0 37 27 9 18 [[220, 486]] 1.0 3i6u Homo sapiens CAMK_CHEK2_HUMAN CAMK 6.3e-84 287.4 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WA O96017 92 501 543.0 No_ligand No_ligand Inactive DFGin 7.3486 13.5162 None -131.02, -176.1 64.38, 89.31 -97.7, 999.0 302.36, 133.8 999.0, 999.0 out-none out 13.0764 Saltbr-none 999.0 HRD-in -64.4, -41.66 75.43, -23.93 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.49, -47.48 999.0, -37.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.25 0.252 0.287 A 443.0 369.0 41 27 9 18 [[220, 486]] 1.0 3i6w Homo sapiens CAMK_CHEK2_HUMAN CAMK 7.4e-84 287.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WC O96017 92 501 543.0 No_ligand No_ligand Inactive DFGin 7.5775 13.998 None -131.8, -178.23 63.57, 98.9 -117.45, 999.0 335.54, 98.66 999.0, 999.0 out-none out 13.0805 Saltbr-none 999.0 HRD-in -63.6, -43.12 77.0, -24.17 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.04, -46.8 999.0, -37.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.25 0.252 0.287 C 443.0 368.0 42 27 9 18 [[220, 486]] 1.0 3i6w Homo sapiens CAMK_CHEK2_HUMAN CAMK 7.4e-84 287.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WE O96017 92 501 543.0 No_ligand No_ligand Inactive DFGin 7.5459 13.6974 None -130.93, -177.05 65.38, 105.03 -130.22, 999.0 325.6, 106.63 999.0, 999.0 out-none out 13.0915 Saltbr-none 999.0 HRD-in -61.69, -42.13 73.77, -23.14 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.57, -46.22 999.0, -36.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.25 0.252 0.287 E 443.0 368.0 42 27 9 18 [[220, 486]] 1.0 3i6w Homo sapiens CAMK_CHEK2_HUMAN CAMK 7.4e-84 287.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN 3I6WG O96017 92 501 543.0 No_ligand No_ligand Inactive DFGin 7.5136 13.8031 None -131.95, -176.65 65.29, 79.69 -111.56, 999.0 332.1, 109.83 999.0, 999.0 out-none out 13.0784 Saltbr-none 999.0 HRD-in -62.8, -42.52 74.63, -23.4 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.54, -46.24 999.0, -36.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K249R None None XRAY 3.25 0.252 0.287 G 443.0 369.0 41 27 9 18 [[220, 486]] 1.0 3i6w Homo sapiens CAMK_CHEK2_HUMAN CAMK 7.4e-84 287.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK MARK2 MARK2_HUMAN 5KZ7A Q7KZI7 48 363 788.0 6Z2:401 Type1 Inactive DFGin 6.1798 15.1923 None -66.59, -98.89 -137.2, 177.34 -105.99, 0.84 306.21, 67.89 -39.62, 999.0 in-out in 9.3332 Saltbr-out 3.9373 HRD-in -57.93, -35.05 64.12, -16.36 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -56.94 APE8-rot-out 193.16 APE67-dihe-in -59.38, -16.94 -59.8, -39.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.226 0.293 A 346.0 296.0 20 27 11 16 [[53, 304]] 1.0 5kz7 Homo sapiens CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_HUMAN 5KZ8A Q7KZI7 48 363 788.0 6Z5:401 Type1 Inactive DFGin 6.6608 14.8467 None -66.62, -138.3 -110.24, 161.57 -113.14, 60.74 323.38, 77.32 145.61, 999.0 in-out in 9.5893 Saltbr-out 4.8664 HRD-in -68.17, -39.88 60.26, -10.16 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 142.11 APE9-dihe-na -96.01, 39.12 APE8-dihe-out -76.41, -33.97 APE8-rot-out 180.16 APE67-dihe-in -71.46, -15.13 -73.47, -29.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5634 None None None XRAY 3.21 0.222 0.29 A 346.0 302.0 14 27 13 14 [[53, 304]] 1.0 5kz8 Homo sapiens CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_HUMAN 5KZ8B Q7KZI7 48 363 788.0 6Z5:401 Type1 Inactive DFGin 7.4263 15.8016 None -67.43, 142.07 -36.53, 154.18 -125.77, 99.94 7.04, 147.55 143.09, 999.0 in-out in 9.6021 Saltbr-out 4.8858 HRD-in -66.11, -40.74 54.9, 7.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -66.07 APE8-rot-out 193.35 APE67-dihe-in -71.07, -14.96 -58.24, -27.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.21 0.222 0.29 B 346.0 300.0 16 27 11 16 [[53, 304]] 1.0 5kz8 Homo sapiens CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK4 MARK4_HUMAN 5ES1A Q96L34 54 370 752.0 5RC:64000 Type1 Inactive DFGin 7.2886 14.3491 None -110.73, 167.87 94.58, -106.37 80.67, 9.01 291.5, 96.97 -62.77, -44.52 in-in in 9.1567 Saltbr-in 3.05 HRD-in -47.94, -47.33 60.65, 3.33 in-in-none SNCiin in-none ActLoopNT-in 3.2249 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.88 APE8-rot-none 999.0 APE67-dihe-in -54.77, -17.8 -67.3, -52.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.243 0.311 A 328.0 304.0 13 27 14 13 [[59, 310]] 1.0 5es1 Homo sapiens CAMK_MARK4_HUMAN CAMK 2.4e-96 328.0 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
CAMK MELK MELK_HUMAN 5TWYA Q14680 2 333 651.0 7LY:64000 Type1 Inactive DFGin 6.2612 16.0842 None -134.84, -164.53 52.57, 45.85 -53.49, -63.86 258.25, 62.71 46.97, -72.76 out-out out 10.0719 Saltbr-out 4.1074 HRD-in -82.2, -30.32 67.57, -22.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.4 APE8-dihe-out -98.48, 8.41 APE8-rot-none 999.0 APE67-dihe-in -62.0, -32.92 -89.48, -29.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.225 None None None XRAY 2.91 0.288 0.33 A 341.0 311.0 21 29 14 15 [[11, 263]] 1.0 5twy Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 5MAIA Q14680 2 333 651.0 5U5:60402 Type1 Inactive DFGin 8.1092 15.0116 None -132.28, 170.97 62.08, 71.15 -94.74, 999.0 292.75, 79.84 999.0, 999.0 out-out out 11.8822 Saltbr-out 8.2222 HRD-in -86.33, -52.07 84.11, -4.76 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -42.92 APE8-rot-out 218.22 APE67-dihe-in -56.7, -25.99 -57.2, -38.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.192 0.237 A 347.0 311.0 19 29 10 19 [[11, 263]] 1.0 5mai Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MKNK2 MKNK2_HUMAN 2AC5A Q9HBH9 72 370 465.0 No_ligand No_ligand Inactive DFGin 5.9629 14.24 None 179.06, 141.31 141.75, -84.88 81.59, -68.22 316.67, 112.33 -126.47, 999.0 in-in in 9.4123 Saltbr-in 2.689 HRD-in -78.97, -46.18 65.28, 3.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -146.04, 164.66 APE9-dihe-na -132.94, -20.66 APE8-dihe-out -93.96, 15.45 APE8-rot-out 50.08 APE67-dihe-in -55.42, -30.57 -62.55, -42.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.5744 D228G None None XRAY 3.2 0.306 0.306 A 316.0 274.0 25 35 14 21 [[83, 368]] 1.0 2ac5 Homo sapiens CAMK_MKNK2_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 225 226 227 229 231 113 129 133 202 204 203 205.0 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK MKNK2 MKNK2_HUMAN 8P9BA Q9HBH9 72 369 465.0 X8K:60402 Type1 Inactive DFGin 5.876 13.7919 None -150.06, 169.8 73.67, 48.24 -60.02, 999.0 327.08, 142.95 999.0, 999.0 in-in in 9.5716 Saltbr-in 2.6981 HRD-in -79.87, -54.07 80.13, -12.9 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.5 APE8-rot-none 999.0 APE67-dihe-in -71.68, -12.3 -89.2, -5.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D228G None None XRAY 2.59 0.211 0.264 A 316.0 262.0 36 35 10 25 [[83, 368]] 1.0 8p9b Homo sapiens CAMK_MKNK2_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 225 226 227 229 231 113 129 133 202 204 203 205.0 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK PIM1 PIM1_HUMAN 4IAAA P11309 33 305 313.0 RTZ:401 Type1 Inactive DFGin 6.018 14.534 None -118.73, -143.64 -58.0, 140.84 -105.0, 12.55 279.89, 91.42 -63.74, -38.82 in-in in 8.9764 Saltbr-in 2.4263 HRD-naA -66.74, -45.93 76.57, 1.9 in-in-in SNCiii in-in ActLoopNT-in 2.8243 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.97, 36.36 APE9-dihe-na -102.7, -148.72 APE8-dihe-in -99.25, 120.44 APE8-rot-in 325.38 APE67-dihe-in -56.81, -14.63 -51.76, -61.55 APE12-dist-in 9.3212 APE11-dist-in 8.4746 APE10-dist-in 4.9412 APE9-dist-in 4.319 None SEP261 SEP261 XRAY 2.85 0.187 0.231 A 289.0 273.0 0 26 26 0 [[38, 290]] 1.0 4iaa Homo sapiens CAMK_PIM1_HUMAN CAMK 3e-65 226.0 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4XH6A P11309 33 305 313.0 HUL:401 Type1 Inactive DFGin 6.0669 14.6256 None -113.12, -75.74 -81.94, 104.4 -86.86, 17.15 286.29, 78.0 -66.66, -16.93 in-in in 8.963 Saltbr-in 2.6759 HRD-naA -71.75, -47.81 68.98, 9.54 in-in-in SNCiii in-in ActLoopNT-in 2.8264 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.53, 35.49 APE9-dihe-na -89.22, -153.74 APE8-dihe-in -92.85, 123.83 APE8-rot-in 304.19 APE67-dihe-in -63.31, -10.32 -62.77, -45.27 APE12-dist-in 9.5688 APE11-dist-in 8.4688 APE10-dist-in 5.5301 APE9-dist-in 3.7526 None None None XRAY 2.04 0.202 0.226 A 294.0 273.0 0 26 26 0 [[38, 290]] 1.0 4xh6 Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 225.9 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PLK4 PLK4_HUMAN 4JXFA O00444 4 267 970.0 631:301 Type1 Inactive DFGin 5.7745 13.791 None -95.55, -28.87 -121.14, 110.52 -136.15, 55.1 41.08, 91.01 69.3, 11.21 out-out out 11.6408 Saltbr-out 8.5517 HRD-out 45.86, -148.81 -144.85, 178.66 out-out-none SNCoon out-none ActLoopNT-out 14.0667 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.255 0.268 A 266.0 235.0 29 28 12 16 [[12, 265]] 1.0 4jxf Homo sapiens CAMK_PLK4_HUMAN CAMK 4.1e-82 281.3 1.0 256.0 256.0 153 154 155 157 159 41 60 64 133 135 134 136.0 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN 4YURA O00444 5 266 970.0 4J7:1000 Type1 Inactive DFGin 5.388 13.6509 None -131.67, -52.13 -104.4, 50.59 -77.08, 999.0 54.8, 85.2 999.0, 999.0 out-out out 10.8729 Saltbr-out 8.065 HRD-out -81.06, -148.13 -47.97, 147.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.202 0.27 A 278.0 226.0 36 28 2 26 [[12, 265]] 1.0 4yur Homo sapiens CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1.0 256.0 256.0 153 154 155 157 159 41 60 64 133 135 134 136.0 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PRKAA1 AAPK1_HUMAN 7JHHA Q13131 22 559 559.0 No_ligand No_ligand Inactive DFGin 4.4083 14.0535 None -72.1, -47.74 -146.41, 153.99 -125.94, -39.52 58.73, 92.29 -80.39, -25.75 out-out out 12.6904 Saltbr-out 12.814 HRD-out -119.19, 87.53 -68.79, -38.46 out-out-out SNCooo out-out ActLoopNT-out 5.2997 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -67.5, -39.69 APE9-dihe-na -65.47, -47.47 APE8-dihe-in -135.51, 108.04 APE8-rot-in 295.83 APE67-dihe-in -65.04, -42.29 -74.22, -38.89 APE12-dist-in 11.9622 APE11-dist-out 17.0132 APE10-dist-out 19.009 APE9-dist-out 12.742 None None None EM 3.92 999.0 999.0 A 484.0 379.0 0 27 27 0 [[27, 279]] 1.0 7jhh Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 7JHGA Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 3.9583 12.3851 None -75.55, -57.95 -128.11, 115.65 -75.63, -58.59 53.99, 94.22 -113.12, -1.21 out-out out 12.413 Saltbr-out 12.2756 HRD-out -118.93, 87.19 -68.87, -35.95 out-out-out SNCooo out-out ActLoopNT-out 5.7547 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.04, -42.27 APE9-dihe-na -68.52, -40.55 APE8-dihe-in -128.24, 81.11 APE8-rot-out 178.77 APE67-dihe-in -67.22, -49.66 -68.38, -37.04 APE12-dist-in 12.5847 APE11-dist-out 17.7613 APE10-dist-out 17.9846 APE9-dist-out 11.2385 None None None EM 3.47 999.0 999.0 A 484.0 380.0 0 27 27 0 [[27, 279]] 1.0 7jhg Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 7M74A Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 4.8105 13.2336 None -76.76, -62.2 -122.49, 107.13 -85.46, -38.34 61.13, 92.05 -117.4, -4.69 out-out out 13.6955 Saltbr-out 11.2388 HRD-out -115.45, 89.03 -69.29, -34.6 out-out-out SNCooo out-out ActLoopNT-out 5.6069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -77.56, -39.26 APE9-dihe-na -72.79, -36.52 APE8-dihe-in -124.27, 83.8 APE8-rot-out 178.33 APE67-dihe-in -73.53, -46.6 -74.47, -34.26 APE12-dist-in 12.8577 APE11-dist-out 17.936 APE10-dist-out 18.1451 APE9-dist-out 11.1081 None None None EM 3.93 999.0 999.0 A 484.0 380.0 0 27 27 0 [[27, 279]] 1.0 7m74 Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4RERA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.7243 14.6822 None -104.41, -74.44 -70.58, 123.21 -111.45, 7.12 271.34, 95.59 -64.34, -25.66 in-in in 9.3938 Saltbr-in 3.1678 HRD-out -106.73, 104.09 -76.93, -37.65 in-in-in SNCiii in-in ActLoopNT-in 2.9275 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.23, 162.43 APE9-dihe-na 109.76, -176.61 APE8-dihe-in -65.38, 159.16 APE8-rot-in 282.67 APE67-dihe-in -82.84, -28.7 -67.98, -40.26 APE12-dist-in 8.7645 APE11-dist-in 11.1018 APE10-dist-in 5.3529 APE9-dist-in 4.5655 E480G,E483A,K485A TPO183 TPO183 XRAY 4.047 0.227 0.26 A 540.0 459.0 0 27 27 0 [[27, 279]] 1.0 4rer Homo sapiens CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REWA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.2816 14.4447 None -106.98, -78.3 -79.98, 116.66 -98.66, 4.74 266.69, 106.69 -52.57, -49.44 out-out out 10.8944 Saltbr-out 4.8489 HRD-out -91.4, 104.28 -79.59, -35.51 out-in-out SNCoio in-out ActLoopNT-in 2.9485 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -146.3, 177.71 APE9-dihe-na 92.22, 179.97 APE8-dihe-in -62.77, 176.84 APE8-rot-in 309.53 APE67-dihe-in -79.73, -37.36 -85.43, -26.86 APE12-dist-in 9.0318 APE11-dist-in 10.9116 APE10-dist-in 6.0735 APE9-dist-out 7.1663 E480G,E483A,K485A None None XRAY 4.58 0.234 0.259 A 540.0 411.0 0 27 27 0 [[27, 279]] 1.0 4rew Homo sapiens CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 7MYJC P54646 8 551 552.0 4O7:601 Type1 Inactive DFGin 7.3145 14.0838 None -132.52, -55.68 -74.88, 101.59 -98.84, 25.6 284.87, 89.61 -69.31, -43.09 out-in out 10.1906 Saltbr-in 3.2112 HRD-in -59.12, -60.67 79.22, -0.71 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.77, 22.41 APE9-dihe-na -62.18, -179.97 APE8-dihe-in -59.88, 136.16 APE8-rot-in 296.22 APE67-dihe-in -61.7, -38.21 -62.19, -37.1 APE12-dist-in 8.6761 APE11-dist-out 7.9979 APE10-dist-out 8.1101 APE9-dist-in 4.3745 None TPO172 TPO172 XRAY 2.95 0.215 0.243 C 565.0 465.0 0 27 27 0 [[16, 268]] 1.0 7myj Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVA P54646 8 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.2674 14.6333 None -121.03, -63.06 -68.65, 101.9 -100.19, 25.35 279.34, 91.81 -68.17, -44.69 in-in in 9.8608 Saltbr-in 2.6899 HRD-in -59.46, -47.11 63.8, -4.14 in-in-in SNCiii in-in ActLoopNT-in 3.0028 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.63, 144.51 APE9-dihe-na 86.66, 177.12 APE8-dihe-in -64.88, 140.75 APE8-rot-in 312.82 APE67-dihe-in -66.61, -22.38 -58.4, -32.39 APE12-dist-in 7.7539 APE11-dist-in 10.4368 APE10-dist-in 5.1306 APE9-dist-in 4.4026 None TPO172 TPO172 XRAY 2.99 0.225 0.245 A 560.0 433.0 0 27 27 0 [[16, 268]] 1.0 5ezv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVC P54646 9 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.4323 14.3494 None -121.9, -67.2 -69.32, 103.91 -104.03, 30.29 280.2, 90.51 -70.5, -44.85 out-in out 10.4146 Saltbr-in 3.2079 HRD-in -65.9, -50.28 64.78, -4.1 in-in-out SNCiio in-out ActLoopNT-in 2.9393 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.83, 151.12 APE9-dihe-na 88.46, 177.26 APE8-dihe-in -64.21, 140.09 APE8-rot-out 194.68 APE67-dihe-in -65.12, -32.21 -57.93, -31.87 APE12-dist-in 7.8362 APE11-dist-in 10.5358 APE10-dist-in 5.1127 APE9-dist-in 4.4856 None TPO172 TPO172 XRAY 2.99 0.225 0.245 C 560.0 434.0 0 27 27 0 [[16, 268]] 1.0 5ezv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4ZHXC P54646 9 551 552.0 4O7:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.1494 14.357 None -118.59, -65.8 -66.91, 99.09 -101.33, 23.32 277.19, 90.56 -65.31, -32.83 out-out out 10.3303 Saltbr-out 4.842 HRD-out -73.9, 101.83 -92.2, 22.13 out-in-out SNCoio in-out ActLoopNT-in 2.9999 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -139.02, 115.25 APE9-dihe-na 47.21, -160.8 APE8-dihe-out 29.45, 76.85 APE8-rot-in 332.18 APE67-dihe-in -70.92, -30.7 -62.41, -34.95 APE12-dist-in 7.9051 APE11-dist-in 10.9947 APE10-dist-in 5.5352 APE9-dist-out 6.3235 None TPO172 TPO172 XRAY 2.99 0.226 0.243 C 565.0 453.0 0 27 27 0 [[16, 268]] 1.0 4zhx Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UA P54646 8 550 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.2691 14.4408 None -129.47, -55.38 -79.75, 100.47 -94.16, 25.18 281.88, 87.91 -69.36, -38.1 out-in out 10.0903 Saltbr-in 2.8061 HRD-in -70.7, -48.35 62.09, 8.12 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.71, 141.45 APE9-dihe-na 98.59, 173.56 APE8-dihe-in -72.38, 142.58 APE8-rot-out 181.03 APE67-dihe-in -62.9, -27.33 -58.67, -32.16 APE12-dist-in 7.9718 APE11-dist-in 10.5218 APE10-dist-in 4.9765 APE9-dist-in 3.8757 None TPO172 TPO172 XRAY 2.77 0.196 0.226 A 565.0 442.0 0 27 27 0 [[16, 268]] 1.0 6b1u Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFC P54646 10 551 552.0 STU:61552,C1V:61553 Type1,Allosteric Inactive DFGin 6.7813 14.0798 None -150.62, -172.52 53.67, 68.27 -65.24, -76.3 281.99, 78.69 54.48, -69.27 out-out out 10.8955 Saltbr-out 5.3095 HRD-out -84.81, 105.73 -92.0, 12.06 out-in-out SNCoio in-out ActLoopNT-in 3.0342 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -122.19, 170.3 APE9-dihe-na 112.32, 178.27 APE8-dihe-in -67.95, 156.54 APE8-rot-out 180.36 APE67-dihe-out -82.42, 177.62 -55.27, -42.84 APE12-dist-in 7.7542 APE11-dist-in 11.1374 APE10-dist-in 5.4326 APE9-dist-in 3.967 None TPO172 TPO172 XRAY 3.924 0.211 0.264 C 571.0 423.0 0 27 27 0 [[16, 268]] 1.0 4cff Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK STK11 STK11_HUMAN 8VSUC Q15831 41 347 433.0 No_ligand No_ligand Inactive DFGin 6.4464 14.5042 None -110.4, -67.17 -83.35, 83.69 -74.95, 5.93 266.62, 73.52 -67.08, -28.88 in-in in 9.5869 Saltbr-in 2.8954 HRD-out -94.66, 95.31 -74.45, 3.43 in-in-in SNCiii in-in ActLoopNT-in 2.8361 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.67, 165.4 APE9-dihe-na 90.11, -175.94 APE8-dihe-in -66.66, 120.5 APE8-rot-in 303.23 APE67-dihe-in -69.02, -14.26 -53.47, -39.98 APE12-dist-in 9.6719 APE11-dist-in 11.3659 APE10-dist-in 5.6526 APE9-dist-in 4.1409 None None None EM 2.86 999.0 999.0 C 449.0 307.0 0 30 30 0 [[49, 309]] 1.0 8vsu Homo sapiens CAMK_STK11_HUMAN CAMK 9.8e-67 231.0 1.0 256.0 256.0 193 194 195 197 199 78 98 102 173 175 174 176.0 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CK1 VRK1 VRK1_HUMAN 2KTYA Q99986 1 360 396.0 No_ligand No_ligand Inactive DFGin 5.3243 15.1527 None -89.4, 48.25 -88.38, 13.56 -67.73, -15.51 318.79, 139.99 -118.73, -3.9 in-out in 9.5884 Saltbr-out 4.6509 HRD-out -78.42, 104.69 -109.22, 23.05 out-in-out SNCoio in-out ActLoopNT-in 3.1507 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -48.81, -30.88 APE9-dihe-na -140.12, -137.46 APE8-dihe-in -89.92, 130.62 APE8-rot-out 194.46 APE67-dihe-in -50.66, -57.74 -50.93, -21.33 APE12-dist-in 10.4757 APE11-dist-in 11.3557 APE10-dist-in 5.7463 APE9-dist-out 7.4012 None None None NMR 999.0 999.0 999.0 A 368.0 360.0 0 35 35 0 [[37, 326]] 1.0 2kty Homo sapiens CK1_VRK1_HUMAN CK1 9.8e-106 358.9 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 2KULA Q99986 1 360 396.0 No_ligand No_ligand Inactive DFGin 6.2491 13.1589 None -136.39, -155.46 72.24, -78.37 55.92, -7.95 293.82, 125.62 -72.72, -31.43 in-in in 8.5828 Saltbr-in 2.6169 HRD-out -119.9, 103.12 -73.71, -46.93 in-in-out SNCiio in-out ActLoopNT-in 2.7684 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -76.69, -64.74 APE9-dihe-na -109.51, -104.17 APE8-dihe-in -89.82, 146.99 APE8-rot-out 38.36 APE67-dihe-in -74.0, -55.74 -68.22, -27.75 APE12-dist-in 10.5392 APE11-dist-in 9.9102 APE10-dist-in 4.082 APE9-dist-out 6.8565 None None None NMR 999.0 999.0 999.0 A 368.0 360.0 0 35 35 0 [[37, 326]] 1.0 2kul Homo sapiens CK1_VRK1_HUMAN CK1 9.8e-106 358.9 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CMGC CDK12 CDK12_HUMAN 8BUGH Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 6.8959 15.5984 None -126.85, -81.65 -69.29, 99.31 -95.06, 17.81 283.55, 80.77 -62.15, -37.73 in-out in 8.4976 Saltbr-out 4.2388 HRD-in -64.31, -53.09 70.58, 6.39 out-in-out SNCoio in-out ActLoopNT-in 3.0823 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.05, -49.38 APE9-dihe-na -69.37, 152.54 APE8-dihe-in -59.34, 145.1 APE8-rot-out 62.3 APE67-dihe-in -62.01, -33.03 -53.97, -44.11 APE12-dist-in 12.9733 APE11-dist-in 12.4826 APE10-dist-in 6.5883 APE9-dist-in 3.6522 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1B Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.8884 15.2984 None -128.47, -62.59 -80.73, 98.22 -97.65, 30.1 286.08, 74.34 -69.36, -27.39 in-in in 7.8207 Saltbr-in 3.2637 HRD-in -79.79, -51.42 72.8, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.7133 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.4, -55.58 APE9-dihe-na -85.22, 150.62 APE8-dihe-in -62.26, 144.21 APE8-rot-out 179.44 APE67-dihe-in -65.72, -30.15 -51.5, -38.4 APE12-dist-in 13.2818 APE11-dist-in 11.6162 APE10-dist-in 6.9008 APE9-dist-in 3.7142 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 B 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.9866 15.4035 None -124.14, -66.45 -82.78, 98.54 -96.09, 28.76 284.79, 71.99 -70.28, -26.46 in-in in 7.8662 Saltbr-in 3.166 HRD-in -79.63, -53.16 73.52, -1.03 in-in-out SNCiio in-out ActLoopNT-in 2.7593 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.57, -50.83 APE9-dihe-na -86.52, 154.66 APE8-dihe-in -59.58, 143.86 APE8-rot-out 8.75 APE67-dihe-in -65.52, -30.46 -51.58, -39.94 APE12-dist-in 13.8095 APE11-dist-in 12.2137 APE10-dist-in 7.2362 APE9-dist-in 3.5954 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU2B Q9NYV4 715 1041 1490.0 RVQ:61101 Type1 Inactive DFGin 6.9805 15.316 None -126.39, -67.8 -89.47, 99.61 -92.58, 32.18 287.62, 78.29 -74.11, -9.98 in-in in 7.7621 Saltbr-in 3.4941 HRD-in -72.7, -49.44 72.16, 4.81 in-in-in SNCiii in-in ActLoopNT-in 2.9597 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.12, -45.69 APE9-dihe-na -96.32, 148.59 APE8-dihe-in -57.39, 143.59 APE8-rot-in 288.86 APE67-dihe-in -63.0, -36.42 -47.95, -40.21 APE12-dist-in 13.5359 APE11-dist-in 11.7305 APE10-dist-in 7.073 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bu2 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU3B Q9NYV4 715 1040 1490.0 RSI:1101 Type1 Inactive DFGin 6.8486 15.3593 None -135.97, -63.81 -78.62, 93.23 -91.89, 22.93 285.59, 76.13 -60.89, -23.4 in-in in 7.9934 Saltbr-in 2.817 HRD-in -67.65, -55.64 77.98, -1.58 in-in-in SNCiii in-in ActLoopNT-in 3.0522 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.96, -44.7 APE9-dihe-na -101.31, 148.75 APE8-dihe-in -59.73, 145.03 APE8-rot-in 305.94 APE67-dihe-in -60.6, -36.33 -55.27, -39.92 APE12-dist-in 13.312 APE11-dist-in 11.5417 APE10-dist-in 7.0493 APE9-dist-in 3.3827 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU3H Q9NYV4 715 1044 1490.0 RSI:1101 Type1 Inactive DFGin 6.9756 15.4654 None -130.35, -57.76 -91.85, 92.73 -91.21, 19.54 285.51, 78.88 -63.9, -27.23 in-in in 8.132 Saltbr-in 3.2809 HRD-in -66.37, -58.1 77.05, -1.53 in-in-out SNCiio in-out ActLoopNT-in 3.0176 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.62, -44.32 APE9-dihe-na -91.3, 148.63 APE8-dihe-in -63.87, 147.34 APE8-rot-out 172.41 APE67-dihe-in -60.12, -36.58 -54.35, -41.92 APE12-dist-in 13.7142 APE11-dist-in 11.8523 APE10-dist-in 6.8179 APE9-dist-in 3.3613 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.9424 15.1221 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.3713 Saltbr-out 3.6222 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.7589 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.1246 APE11-dist-in 12.1682 APE10-dist-in 7.2856 APE9-dist-in 3.7263 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU6B Q9NYV4 715 1039 1490.0 RQE:61101 Type1 Inactive DFGin 6.9772 15.0095 None -127.82, -64.26 -87.77, 91.87 -89.24, 20.45 288.89, 72.08 -65.57, -40.39 in-in in 8.424 Saltbr-in 3.4813 HRD-in -70.61, -57.84 77.83, -2.42 in-in-out SNCiio in-out ActLoopNT-in 3.1224 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.14, -54.56 APE9-dihe-na -81.61, 149.37 APE8-dihe-in -53.79, 145.32 APE8-rot-out 74.18 APE67-dihe-in -56.42, -37.71 -55.03, -39.62 APE12-dist-in 13.9274 APE11-dist-in 11.7836 APE10-dist-in 6.969 APE9-dist-in 3.408 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU6H Q9NYV4 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.8592 15.2278 None -123.73, -80.29 -80.87, 99.66 -87.02, 20.65 285.61, 58.62 -65.39, -44.16 in-out in 8.4216 Saltbr-out 5.0958 HRD-in -73.68, -57.19 78.4, -0.7 out-in-out SNCoio in-out ActLoopNT-in 3.0861 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.54, -53.3 APE9-dihe-na -74.55, 153.16 APE8-dihe-in -53.11, 139.67 APE8-rot-out 166.86 APE67-dihe-in -53.97, -35.01 -57.57, -41.34 APE12-dist-in 13.1365 APE11-dist-in 12.4283 APE10-dist-in 7.0199 APE9-dist-in 3.4215 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.8954 15.5504 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.0334 Saltbr-in 3.4619 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.0383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.2624 APE11-dist-in 11.7849 APE10-dist-in 6.4997 APE9-dist-in 3.5775 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUBH Q9NYV4 715 1044 1490.0 RNU:61102 Type1 Inactive DFGin 7.2638 15.677 None -126.03, -25.89 -87.61, 72.88 -91.51, 12.82 280.63, 73.67 -60.75, -39.82 in-in in 8.4819 Saltbr-in 3.5525 HRD-out -79.78, 93.25 -67.97, -38.17 in-out-out SNCioo out-out ActLoopNT-out 3.72 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -109.56, -9.94 APE9-dihe-na -106.55, 22.31 APE8-dihe-out 64.82, 23.4 APE8-rot-out 71.99 APE67-dihe-out -104.68, -30.69 71.46, -1.72 APE12-dist-in 12.7113 APE11-dist-in 12.093 APE10-dist-in 6.8605 APE9-dist-in 4.5978 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUCH Q9NYV4 715 1044 1490.0 RKO:61101 Type1 Inactive DFGin 6.938 15.2425 None -126.85, -64.01 -88.43, 98.06 -96.23, 24.88 287.21, 69.27 -75.34, -9.66 in-in in 7.9464 Saltbr-in 3.3005 HRD-in -84.47, -51.91 75.61, -7.74 in-in-in SNCiii in-in ActLoopNT-in 2.9789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, -52.72 APE9-dihe-na -81.82, 150.47 APE8-dihe-in -58.85, 136.79 APE8-rot-in 300.83 APE67-dihe-in -60.33, -38.14 -49.32, -40.23 APE12-dist-in 13.7625 APE11-dist-in 11.7819 APE10-dist-in 6.9727 APE9-dist-in 3.2597 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUEB Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.8762 15.6 None -134.01, -59.19 -81.95, 94.22 -92.57, 38.59 286.02, 76.0 -80.72, -24.77 in-in in 7.932 Saltbr-in 2.9874 HRD-in -72.56, -56.91 77.87, 2.52 in-in-out SNCiio in-out ActLoopNT-in 2.9042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.91, -27.24 APE9-dihe-na -111.61, 155.18 APE8-dihe-in -59.11, 144.49 APE8-rot-out 174.63 APE67-dihe-in -64.14, -33.78 -56.66, -36.69 APE12-dist-in 13.2286 APE11-dist-in 11.5753 APE10-dist-in 6.8399 APE9-dist-in 3.7328 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUFB Q9NYV4 715 1033 1490.0 RW6:61101 Type1 Inactive DFGin 6.9051 15.6357 None -129.93, -62.21 -79.23, 97.53 -95.7, 37.47 286.05, 76.01 -76.9, -21.74 in-in in 8.1053 Saltbr-in 3.1532 HRD-in -72.11, -52.31 75.51, 2.58 in-in-out SNCiio in-out ActLoopNT-in 2.8864 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.68, -63.24 APE9-dihe-na -77.98, 146.57 APE8-dihe-in -61.93, 149.44 APE8-rot-out 186.78 APE67-dihe-in -61.63, -31.53 -53.67, -39.8 APE12-dist-in 13.1702 APE11-dist-in 10.9939 APE10-dist-in 6.5903 APE9-dist-in 3.5503 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 B 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8buf Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUFH Q9NYV4 715 1032 1490.0 RW6:61101 Type1 Inactive DFGin 7.1171 15.5053 None -129.62, -58.72 -84.56, 91.07 -93.16, 33.34 286.36, 76.3 -77.96, -20.03 in-out in 8.1468 Saltbr-out 3.7328 HRD-in -74.59, -54.27 72.47, 1.47 out-in-in SNCoii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.36, -62.78 APE9-dihe-na -81.18, 153.72 APE8-dihe-in -60.4, 148.16 APE8-rot-in 306.45 APE67-dihe-in -63.34, -32.17 -56.22, -41.31 APE12-dist-in 13.7169 APE11-dist-in 11.792 APE10-dist-in 7.061 APE9-dist-in 3.3785 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 H 344.0 318.0 0 29 29 0 [[727, 1020]] 1.0 8buf Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUGB Q9NYV4 715 1041 1490.0 RPW:61101 Type1 Inactive DFGin 6.885 15.532 None -132.35, -51.84 -89.28, 88.82 -91.59, 19.28 282.49, 80.64 -62.07, -38.03 in-in in 8.0337 Saltbr-in 2.912 HRD-in -62.84, -54.31 70.37, 7.41 in-in-out SNCiio in-out ActLoopNT-in 3.0011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -68.25, -47.63 APE9-dihe-na -75.15, 151.02 APE8-dihe-in -63.11, 148.71 APE8-rot-out 182.54 APE67-dihe-in -62.59, -33.17 -53.62, -43.42 APE12-dist-in 12.5031 APE11-dist-in 11.8127 APE10-dist-in 6.379 APE9-dist-in 3.619 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUHB Q9NYV4 715 1039 1490.0 RR9:61101 Type1 Inactive DFGin 7.1787 15.539 None -138.13, -51.2 -84.38, 89.05 -94.33, 22.38 291.72, 70.83 -65.07, -27.18 in-in in 8.1562 Saltbr-in 3.1703 HRD-in -65.3, -52.38 69.31, 6.78 in-in-out SNCiio in-out ActLoopNT-in 2.9184 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.08, -42.42 APE9-dihe-na -75.03, 155.7 APE8-dihe-in -68.77, 151.86 APE8-rot-out 184.25 APE67-dihe-in -61.51, -37.69 -56.24, -40.88 APE12-dist-in 12.2995 APE11-dist-in 11.9854 APE10-dist-in 6.1967 APE9-dist-in 3.6729 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8buh Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUHH Q9NYV4 715 1033 1490.0 RR9:61101 Type1 Inactive DFGin 6.8874 15.2204 None -138.17, -50.63 -86.02, 83.59 -88.15, 19.63 292.55, 71.89 -63.06, -22.61 in-in in 8.184 Saltbr-in 2.9431 HRD-in -66.24, -47.16 69.47, -1.27 in-in-out SNCiio in-out ActLoopNT-in 3.0446 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.8, -40.23 APE9-dihe-na -75.94, 158.01 APE8-dihe-in -67.45, 146.95 APE8-rot-out 179.42 APE67-dihe-in -59.63, -39.48 -58.91, -41.72 APE12-dist-in 13.2298 APE11-dist-in 12.4677 APE10-dist-in 6.767 APE9-dist-in 3.3762 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 H 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8buh Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUJB Q9NYV4 715 1041 1490.0 RUW:1101 Type1 Inactive DFGin 6.983 15.1999 None -129.99, -57.9 -94.94, 86.34 -84.73, 29.33 287.08, 75.1 -66.06, -25.85 in-in in 7.8642 Saltbr-in 2.9459 HRD-in -63.86, -54.33 75.41, -2.11 in-in-out SNCiio in-out ActLoopNT-in 3.0628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -117.09, -50.74 APE9-dihe-na -90.83, 154.53 APE8-dihe-in -64.5, 148.14 APE8-rot-out 189.98 APE67-dihe-in -60.8, -34.01 -57.18, -38.53 APE12-dist-in 13.2622 APE11-dist-in 11.4247 APE10-dist-in 7.1058 APE9-dist-in 3.5216 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8buj Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUJH Q9NYV4 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 6.896 15.0772 None -125.46, -61.45 -96.84, 87.36 -85.01, 26.05 287.54, 74.01 -66.36, -25.41 in-in in 7.8133 Saltbr-in 3.0099 HRD-in -63.78, -55.47 74.76, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.9668 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.8, -48.82 APE9-dihe-na -90.4, 155.44 APE8-dihe-in -63.14, 147.75 APE8-rot-in 306.89 APE67-dihe-in -59.19, -33.71 -59.17, -40.93 APE12-dist-in 13.546 APE11-dist-in 11.4373 APE10-dist-in 6.9005 APE9-dist-in 3.4536 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8buj Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUKB Q9NYV4 715 1040 1490.0 RWE:61101 Type1 Inactive DFGin 6.8676 15.185 None -136.79, -63.9 -86.16, 95.92 -96.18, 34.75 292.05, 70.82 -73.05, -21.93 in-in in 7.9967 Saltbr-in 2.8964 HRD-in -70.18, -56.12 75.44, 6.36 in-in-in SNCiii in-in ActLoopNT-in 2.9507 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.1, -51.8 APE9-dihe-na -97.16, 156.72 APE8-dihe-in -60.0, 144.72 APE8-rot-in 296.0 APE67-dihe-in -62.91, -30.64 -55.4, -37.75 APE12-dist-in 13.3442 APE11-dist-in 11.4945 APE10-dist-in 7.2213 APE9-dist-in 3.6338 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buk Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUKH Q9NYV4 715 1044 1490.0 RWE:61101 Type1 Inactive DFGin 6.839 15.2471 None -132.41, -70.3 -85.48, 98.43 -94.85, 32.62 289.18, 70.32 -75.66, -23.83 in-in in 8.0838 Saltbr-in 3.0875 HRD-in -67.86, -57.14 74.14, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.8859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.71, -45.22 APE9-dihe-na -97.3, 156.39 APE8-dihe-in -62.45, 146.81 APE8-rot-out 169.98 APE67-dihe-in -63.55, -31.48 -56.16, -39.65 APE12-dist-in 13.6893 APE11-dist-in 11.7966 APE10-dist-in 7.1304 APE9-dist-in 3.7281 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buk Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BULB Q9NYV4 715 1039 1490.0 RSU:1101 Type1 Inactive DFGin 7.0478 15.5723 None -134.15, -61.62 -82.15, 93.36 -91.03, 19.31 284.15, 82.25 -57.36, -30.14 in-in in 7.9382 Saltbr-in 2.9293 HRD-in -70.64, -53.34 75.97, 4.36 in-in-in SNCiii in-in ActLoopNT-in 3.1167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.1, -23.33 APE9-dihe-na -106.91, 152.49 APE8-dihe-in -59.59, 141.04 APE8-rot-in 301.22 APE67-dihe-in -61.09, -37.16 -52.97, -42.84 APE12-dist-in 13.2976 APE11-dist-in 11.6069 APE10-dist-in 6.723 APE9-dist-in 3.6083 None TPO893 TPO893 XRAY 3.4 0.179 0.215 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMB Q9NYV4 715 1040 1490.0 T6X:1101 Type1 Inactive DFGin 6.8637 15.6654 None -134.73, -83.5 -67.29, 93.27 -90.11, 26.53 284.48, 75.06 -65.26, -28.59 in-in in 7.994 Saltbr-in 3.4847 HRD-in -65.89, -56.24 77.66, 6.87 in-in-in SNCiii in-in ActLoopNT-in 3.1268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, -38.62 APE9-dihe-na -95.11, 154.79 APE8-dihe-in -60.97, 148.11 APE8-rot-in 309.8 APE67-dihe-in -61.69, -36.7 -58.55, -38.83 APE12-dist-in 13.4563 APE11-dist-in 11.5984 APE10-dist-in 6.6698 APE9-dist-in 3.6672 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMH Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Inactive DFGin 7.0235 15.4568 None -135.37, -57.05 -84.79, 89.46 -91.01, 22.09 287.95, 72.46 -66.77, -30.21 in-out in 8.0681 Saltbr-out 4.1308 HRD-in -66.21, -56.87 75.95, 5.67 out-in-in SNCoii in-in ActLoopNT-in 2.9548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.45, -40.59 APE9-dihe-na -95.46, 155.5 APE8-dihe-in -61.11, 150.0 APE8-rot-in 312.75 APE67-dihe-in -61.06, -36.71 -56.48, -41.62 APE12-dist-in 13.6249 APE11-dist-in 11.7363 APE10-dist-in 7.1678 APE9-dist-in 3.5793 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUOH Q9NYV4 715 1044 1490.0 RLC:1101 Type1 Inactive DFGin 6.9531 15.2665 None -133.0, -52.84 -89.06, 92.6 -92.03, 19.54 286.01, 76.31 -65.14, -29.67 in-in in 8.1958 Saltbr-in 3.2893 HRD-in -68.8, -55.72 77.31, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.5, -30.39 APE9-dihe-na -96.1, 151.94 APE8-dihe-in -61.51, 140.45 APE8-rot-in 333.9 APE67-dihe-in -58.03, -34.02 -53.9, -41.38 APE12-dist-in 13.5492 APE11-dist-in 11.7907 APE10-dist-in 6.7655 APE9-dist-in 3.3578 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUQH Q9NYV4 715 1035 1490.0 RQ9:61101 Type1 Inactive DFGin 6.8471 15.4131 None -139.0, -68.9 -74.65, 86.14 -87.77, 25.62 285.6, 75.05 -68.98, -27.88 in-in in 8.1409 Saltbr-in 3.3418 HRD-in -71.56, -55.82 75.32, -0.25 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.77, -46.85 APE9-dihe-na -88.37, 155.15 APE8-dihe-in -63.62, 147.91 APE8-rot-out 74.55 APE67-dihe-in -59.91, -28.34 -56.29, -43.5 APE12-dist-in 13.7059 APE11-dist-in 11.9801 APE10-dist-in 7.0593 APE9-dist-in 3.5434 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 H 344.0 321.0 0 29 29 0 [[727, 1020]] 1.0 8buq Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BURH Q9NYV4 715 1039 1490.0 RQU:61101 Type1 Inactive DFGin 6.7739 15.4438 None -128.98, -68.65 -83.3, 94.14 -94.27, 19.71 289.32, 85.87 -66.64, -31.92 in-in in 8.1448 Saltbr-in 2.8791 HRD-in -62.95, -51.76 69.51, 6.54 in-in-out SNCiio in-out ActLoopNT-in 3.108 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.35, -54.64 APE9-dihe-na -87.35, 151.65 APE8-dihe-in -60.57, 144.24 APE8-rot-out 76.95 APE67-dihe-in -62.32, -33.37 -50.2, -40.95 APE12-dist-in 13.7432 APE11-dist-in 11.6616 APE10-dist-in 7.0858 APE9-dist-in 3.6711 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bur Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUSE Q9NYV4 715 1043 1490.0 RMX:1101 Type1 Inactive DFGin 6.7257 15.8693 None -132.84, -50.43 -84.41, 82.25 -87.45, 22.35 281.7, 77.83 -63.73, -33.79 in-in in 8.1583 Saltbr-in 3.2823 HRD-in -70.71, -48.94 71.36, 12.53 in-in-out SNCiio in-out ActLoopNT-in 2.9956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.11, -47.21 APE9-dihe-na -97.32, 150.19 APE8-dihe-in -67.32, 151.1 APE8-rot-out 195.8 APE67-dihe-in -58.67, -27.66 -56.54, -42.34 APE12-dist-in 13.2846 APE11-dist-in 11.3926 APE10-dist-in 7.3398 APE9-dist-in 3.4564 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bus Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.1242 15.0312 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.3316 Saltbr-out 4.4499 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.0722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.9874 APE11-dist-in 12.2701 APE10-dist-in 7.331 APE9-dist-in 3.8645 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351.0 334.0 0 29 29 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 8BYAA P24941 16 296 298.0 No_ligand No_ligand Inactive DFGin 6.9616 16.2924 None -134.63, 82.03 -161.61, 106.37 -138.09, 26.66 284.26, 105.76 -68.14, -60.43 out-none out 10.0623 Saltbr-none 999.0 HRD-out -108.07, -22.97 56.97, -114.32 none-out-out SNCnoo out-out ActLoopNT-out 4.3007 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -82.31, 123.39 APE9-dihe-na -125.74, 132.38 APE8-dihe-in -58.14, 137.63 APE8-rot-in 294.3 APE67-dihe-in -69.0, -10.69 -52.48, -40.96 APE12-dist-in 11.3246 APE11-dist-out 6.4466 APE10-dist-out 9.1399 APE9-dist-out 7.1292 None TPO159 TPO159 EM 3.38 999.0 999.0 A 298.0 277.0 16 28 28 0 [[4, 286]] 1.0 8bya Homo sapiens CMGC_CDK2_HUMAN CMGC 6.1e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5UQ1C P24941 1 289 298.0 No_ligand No_ligand Inactive DFGin 6.5957 15.6532 None -143.1, 67.57 -125.34, 19.31 -94.36, 26.08 301.42, 106.66 -81.71, -31.95 in-in in 9.2997 Saltbr-in 3.187 HRD-in -81.67, -52.04 53.83, 40.34 in-in-out SNCiio in-out ActLoopNT-in 2.7825 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -139.61, -123.49 APE9-dihe-na -60.35, 138.62 APE8-dihe-in -67.73, 105.22 APE8-rot-out 72.15 APE67-dihe-out -22.19, -25.42 16.7, -96.86 APE12-dist-in 12.2985 APE11-dist-in 8.652 APE10-dist-in 7.5404 APE9-dist-in 3.9452 None None None XRAY 3.201 0.208 0.261 C 301.0 289.0 0 28 28 0 [[4, 286]] 1.0 5uq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5OO1A P24941 4 298 298.0 9Z2:301 Type1 Inactive DFGin 7.6369 16.0223 None -121.17, 166.43 66.4, 43.63 -62.57, 999.0 279.44, 78.94 999.0, 999.0 out-out out 15.4399 Saltbr-out 10.7818 HRD-in -81.97, -55.23 75.2, -10.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.58 APE8-dihe-out -76.46, -29.98 APE8-rot-in 295.35 APE67-dihe-in -58.08, -20.66 -40.64, -49.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1659 F80C,C177A None None XRAY 2.0 0.187 0.236 A 303.0 278.0 17 28 11 17 [[4, 286]] 1.0 5oo1 Homo sapiens CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1PYEA P24941 1 298 298.0 PM1:700 Type1 Inactive DFGin 8.2202 15.4649 None -124.58, 165.75 48.02, 64.22 -62.08, 999.0 279.52, 59.87 999.0, 999.0 out-out out 15.012 Saltbr-out 12.4597 HRD-in -83.61, -50.44 78.62, -18.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 167.42 APE9-dihe-na -72.88, 127.15 APE8-dihe-in -72.71, 140.05 APE8-rot-out 63.06 APE67-dihe-in -52.66, -26.74 -106.34, -2.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5475 None None None XRAY 2.0 0.239 0.252 A 298.0 266.0 32 28 12 16 [[4, 286]] 1.0 1pye Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2W05A P24941 1 298 298.0 FRT:1299 Type1 Inactive DFGin 8.9053 15.9289 None -128.23, 165.06 62.24, 43.64 -62.21, -101.33 274.85, 83.58 96.54, -134.12 out-out out 15.0109 Saltbr-out 13.5797 HRD-in -86.31, -48.92 76.7, -14.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.95, 27.61 APE9-dihe-na -84.15, 133.89 APE8-dihe-in -68.78, 136.67 APE8-rot-out 189.07 APE67-dihe-in -51.29, -28.78 -104.64, -0.82 APE12-dist-none 999.0 APE11-dist-out 16.5822 APE10-dist-out 19.1827 APE9-dist-out 10.3722 None None None XRAY 1.9 0.23 0.293 A 298.0 276.0 22 28 15 13 [[4, 286]] 1.0 2w05 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5D1JA P24941 1 298 298.0 56H:4000 Type1 Inactive DFGin 8.6373 15.2838 None -137.97, 170.56 53.49, 55.77 -71.24, 999.0 283.47, 73.89 999.0, 999.0 out-none out 14.9289 Saltbr-none 999.0 HRD-in -80.57, -53.12 79.22, -17.55 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.54 APE8-dihe-in -86.85, 121.49 APE8-rot-in 299.19 APE67-dihe-in -55.62, -31.72 -100.82, -4.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1545 None None None XRAY 1.8 0.203 0.232 A 298.0 265.0 33 28 11 17 [[4, 286]] 1.0 5d1j Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QL8A P24941 1 298 298.0 X01:300 Type1 Inactive DFGin 9.1322 15.4352 None -122.25, 168.91 72.46, -145.11 131.38, -129.83 255.48, 110.66 -62.05, 95.07 out-out out 15.5659 Saltbr-out 15.2062 HRD-in -84.45, -59.47 81.38, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.6087 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -83.89, 109.54 APE9-dihe-na -59.93, 129.67 APE8-dihe-in -81.59, 123.65 APE8-rot-in 299.9 APE67-dihe-in -51.56, -28.22 -100.19, -8.52 APE12-dist-out 19.7188 APE11-dist-out 16.7576 APE10-dist-out 19.0354 APE9-dist-out 11.0608 None None None XRAY 1.9 0.202 0.238 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3ql8 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QWJA P24941 1 298 298.0 X6A:483 Type1 Inactive DFGin 10.8275 18.6046 None -114.29, 146.98 65.6, 42.02 -53.47, -101.22 231.88, 79.31 -68.75, 30.41 out-out out 15.3452 Saltbr-out 12.4266 HRD-in -84.5, -56.26 82.9, -19.63 out-out-out SNCooo out-out ActLoopNT-out 6.1307 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.81, 125.39 APE9-dihe-na -71.61, 131.09 APE8-dihe-in -83.22, 123.55 APE8-rot-in 295.87 APE67-dihe-in -56.8, -26.34 -103.15, 1.31 APE12-dist-out 20.2894 APE11-dist-out 17.6309 APE10-dist-out 19.6755 APE9-dist-out 10.9886 None None None XRAY 1.75 0.206 0.229 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3qwj Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QX4A P24941 1 298 298.0 X4B:454 Type1 Inactive DFGin 10.9876 18.3391 None -117.48, 147.66 64.55, 41.52 -55.77, -90.1 235.01, 81.0 -76.36, 28.96 out-out out 15.6348 Saltbr-out 14.18 HRD-in -81.9, -60.6 86.28, -21.21 out-out-out SNCooo out-out ActLoopNT-out 5.9234 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -65.97, 121.02 APE9-dihe-na -66.55, 127.88 APE8-dihe-in -80.02, 120.64 APE8-rot-in 297.75 APE67-dihe-in -54.34, -28.48 -100.67, -3.24 APE12-dist-out 20.0847 APE11-dist-out 17.4216 APE10-dist-out 19.6901 APE9-dist-out 10.935 None None None XRAY 1.92 0.205 0.238 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3qx4 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3R9HA P24941 1 298 298.0 Z67:606 Type1 Inactive DFGin 8.3031 15.2871 None -120.0, 168.79 77.09, -84.14 71.52, 122.55 279.89, 89.71 -46.26, -69.21 out-out out 14.7757 Saltbr-out 14.153 HRD-in -82.5, -51.28 73.26, -15.2 out-out-out SNCooo out-out ActLoopNT-out 7.8678 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -57.18, 102.97 APE9-dihe-na -66.25, 137.88 APE8-dihe-in -87.27, 136.09 APE8-rot-in 301.21 APE67-dihe-in -49.8, -36.88 -111.15, -2.68 APE12-dist-out 20.7236 APE11-dist-out 17.6738 APE10-dist-out 20.0369 APE9-dist-out 11.0969 None None None XRAY 2.1 0.214 0.259 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3r9h Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RK5A P24941 1 298 298.0 07Z:436 Type1 Inactive DFGin 8.2539 15.1511 None -135.71, 162.54 80.12, -66.74 62.53, 4.94 282.99, 77.39 53.28, -132.52 out-out out 14.7356 Saltbr-out 13.1253 HRD-in -80.28, -56.17 79.56, -17.53 out-out-out SNCooo out-out ActLoopNT-out 7.5753 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.64, 108.95 APE9-dihe-na -69.16, 141.75 APE8-dihe-in -86.76, 130.53 APE8-rot-in 282.62 APE67-dihe-in -51.32, -32.2 -101.03, -6.74 APE12-dist-out 20.0537 APE11-dist-out 16.5631 APE10-dist-out 18.8447 APE9-dist-out 11.0317 None None None XRAY 2.0 0.206 0.238 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3rk5 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RK7A P24941 1 298 298.0 08Z:467 Type1 Inactive DFGin 8.2288 15.1605 None -129.7, 167.95 74.53, -59.76 60.9, 15.2 281.75, 75.35 53.86, -103.4 out-out out 14.8874 Saltbr-out 15.0248 HRD-in -81.84, -56.89 82.92, -16.54 out-out-out SNCooo out-out ActLoopNT-out 7.6756 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.0, 97.8 APE9-dihe-na -61.23, 134.9 APE8-dihe-in -84.34, 129.91 APE8-rot-in 290.25 APE67-dihe-in -55.99, -28.83 -103.41, -0.58 APE12-dist-out 20.8558 APE11-dist-out 17.133 APE10-dist-out 19.5784 APE9-dist-out 11.0607 None None None XRAY 1.8 0.206 0.224 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3rk7 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RKBA P24941 1 298 298.0 12Z:457 Type1 Inactive DFGin 7.9623 15.3438 None -136.32, 169.7 52.72, 57.61 -64.16, -102.19 278.37, 71.06 -78.55, 125.67 out-out out 15.3178 Saltbr-out 13.6224 HRD-in -80.71, -50.21 81.81, -22.27 out-out-out SNCooo out-out ActLoopNT-out 8.9288 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.87, 109.93 APE9-dihe-na -69.0, 132.49 APE8-dihe-in -79.46, 128.25 APE8-rot-out 184.86 APE67-dihe-in -52.12, -32.05 -102.56, -4.29 APE12-dist-out 17.0609 APE11-dist-out 14.0071 APE10-dist-out 16.7881 APE9-dist-out 11.0395 None None None XRAY 2.0 0.207 0.246 A 306.0 294.0 4 28 28 0 [[4, 286]] 1.0 3rkb Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3RM6A P24941 1 298 298.0 18Z:478 Type1 Inactive DFGin 8.595 15.4797 None -127.31, 175.21 70.31, -63.24 64.35, 17.5 284.18, 82.41 61.96, 14.33 out-out out 15.7131 Saltbr-out 17.4313 HRD-in -88.48, -59.71 83.31, -19.73 out-out-out SNCooo out-out ActLoopNT-out 6.2573 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.49, 112.67 APE9-dihe-na -67.84, 129.1 APE8-dihe-in -77.92, 125.13 APE8-rot-out 171.09 APE67-dihe-in -52.76, -26.7 -104.02, -2.64 APE12-dist-out 19.2027 APE11-dist-out 15.5976 APE10-dist-out 18.7719 APE9-dist-out 11.1306 None None None XRAY 1.6 0.22 0.241 A 306.0 293.0 5 28 28 0 [[4, 286]] 1.0 3rm6 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3S0OA P24941 1 298 298.0 50Z:446 Type1 Inactive DFGin 8.5043 14.9871 None -136.17, 174.47 56.71, 50.73 -53.6, 999.0 285.42, 58.7 999.0, 999.0 out-out out 15.686 Saltbr-out 14.1408 HRD-in -92.71, -50.76 76.76, -17.93 out-out-out SNCooo out-out ActLoopNT-out 5.7216 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -76.57, 93.08 APE9-dihe-na -52.85, 136.54 APE8-dihe-in -88.54, 130.77 APE8-rot-out 176.51 APE67-dihe-in -49.84, -33.28 -101.8, -5.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0353 None None None XRAY 2.0 0.213 0.271 A 306.0 293.0 5 28 26 2 [[4, 286]] 1.0 3s0o Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8RU8A P24941 1 298 298.0 I74:301 Type1 Inactive DFGin 8.4918 15.3722 None -138.93, 165.19 64.8, 51.39 -61.53, 999.0 281.7, 71.9 999.0, 999.0 out-out out 15.2096 Saltbr-out 14.4068 HRD-in -79.32, -55.83 85.03, -22.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -92.95, 127.12 APE9-dihe-na -56.69, 130.27 APE8-dihe-in -92.47, 122.83 APE8-rot-in 301.98 APE67-dihe-in -63.56, -25.08 -104.73, 1.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2567 I10L,T14Q,V64I,K88E,K89V,D92K,Q131N None None XRAY 1.51 0.205 0.241 A 306.0 275.0 23 28 14 14 [[4, 286]] 1.0 8ru8 Homo sapiens CMGC_CDK2_HUMAN CMGC 1.5e-88 303.3 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3EZRA P24941 1 298 298.0 EZR:300,EZR:301 Type1,Allosteric Inactive DFGin 10.1386 18.1306 None -127.03, 166.36 56.16, 26.16 -69.94, 999.0 212.22, 111.94 999.0, 999.0 out-out out 14.9797 Saltbr-out 15.4403 HRD-in -76.59, -53.67 86.14, -23.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.39 APE8-rot-out 187.95 APE67-dihe-in -60.61, -23.99 -102.93, -2.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.208 0.243 A 300.0 273.0 25 28 10 18 [[4, 286]] 1.0 3ezr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK4 CDK4_HUMAN 6P8EB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 7.0044 13.6286 None -117.77, -72.88 -107.88, 78.51 -118.9, 163.81 54.02, 80.6 48.95, 65.67 out-out out 12.409 Saltbr-out 13.388 HRD-in -64.13, -55.39 86.4, -18.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.05 APE8-rot-out 188.09 APE67-dihe-in -66.03, -29.27 -109.32, 4.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 G43E,G47E None None XRAY 2.3 0.175 0.222 B 302.0 260.0 31 27 12 15 [[6, 295]] 1.0 6p8e Homo sapiens CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CMGC CDK4 CDK4_HUMAN 6P8FB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 6.7494 13.7427 None -149.06, 177.93 56.83, 84.9 -168.16, 150.56 57.88, 90.12 60.26, 33.17 out-out out 12.4664 Saltbr-out 11.937 HRD-in -67.53, -46.86 65.41, -6.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 167.16 APE8-dihe-in -108.02, 135.84 APE8-rot-out 185.16 APE67-dihe-in -61.26, -17.97 -103.23, 9.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3291 G43E,G47E None None XRAY 2.89 0.189 0.242 B 302.0 262.0 29 27 14 13 [[6, 295]] 1.0 6p8f Homo sapiens CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CMGC CDK4 CDK4_HUMAN 2W9FB P11802 5 295 303.0 No_ligand No_ligand Inactive DFGin 7.1342 12.7862 None -118.14, -62.46 -136.13, 77.76 -93.66, 151.53 25.95, 76.09 57.89, -6.88 out-out out 13.7541 Saltbr-out 16.4265 HRD-in -86.38, -51.14 71.27, -31.56 out-out-none SNCoon out-none ActLoopNT-out 7.2591 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 96.26 APE8-rot-in 295.94 APE67-dihe-in -52.44, -36.01 -70.67, 6.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 G43E,G47E,T172F None None XRAY 2.85 0.229 0.3 B 306.0 261.0 27 27 21 6 [[6, 295]] 1.0 2w9f Homo sapiens CMGC_CDK4_HUMAN CMGC 1.5e-82 285.6 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CMGC CDK7 CDK7_HUMAN 1UA2A P50613 13 311 346.0 ATP:381 ATPlike Inactive DFGin 3.8381 15.0736 None -72.36, 176.54 -63.29, 129.93 -58.5, 61.34 34.11, 88.78 62.95, -115.18 out-out out 13.0144 Saltbr-out 13.6332 HRD-out -71.94, 127.86 -111.75, 17.16 out-out-out SNCooo out-out ActLoopNT-out 10.7811 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.17, 155.77 APE9-dihe-na -94.04, -36.01 APE8-dihe-out 80.52, 83.34 APE8-rot-in 310.15 APE67-dihe-in -70.12, 0.07 -111.89, 13.44 APE12-dist-out 21.6082 APE11-dist-out 18.7453 APE10-dist-out 20.4575 APE9-dist-out 13.0189 None TPO170 TPO170 XRAY 3.02 0.217 0.288 A 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2B P50613 13 311 346.0 ATP:382 ATPlike Inactive DFGin 4.0749 14.4826 None -83.42, -165.13 -43.25, 135.34 -79.47, 27.14 49.47, 35.58 128.26, -117.59 out-out out 13.2082 Saltbr-out 11.1817 HRD-out -90.35, 54.77 -58.64, -3.2 out-out-out SNCooo out-out ActLoopNT-out 10.7547 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -59.37, 128.97 APE9-dihe-na -70.17, -103.62 APE8-dihe-out 114.41, 132.59 APE8-rot-out 86.06 APE67-dihe-in -64.71, -6.03 -138.86, 19.47 APE12-dist-out 21.3562 APE11-dist-out 17.9388 APE10-dist-out 20.1165 APE9-dist-out 13.1186 None TPO170 TPO170 XRAY 3.02 0.217 0.288 B 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2C P50613 13 311 346.0 ATP:383 ATPlike Inactive DFGin 4.3773 15.832 None -69.53, 164.86 -53.4, 113.84 -55.09, 81.41 35.63, 74.81 38.07, -90.08 out-out out 14.2914 Saltbr-out 13.3504 HRD-out -90.81, 75.3 -67.23, 24.34 out-out-out SNCooo out-out ActLoopNT-out 10.7246 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.3, 146.02 APE9-dihe-na -103.14, 168.98 APE8-dihe-in -149.98, 115.15 APE8-rot-in 317.59 APE67-dihe-in -70.34, -0.48 -115.08, 9.43 APE12-dist-out 21.9947 APE11-dist-out 19.6363 APE10-dist-out 20.1195 APE9-dist-out 12.6188 None TPO170 TPO170 XRAY 3.02 0.217 0.288 C 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2D P50613 13 311 346.0 ATP:384 ATPlike Inactive DFGin 3.9714 15.4823 None -66.13, 178.54 -66.01, 128.6 -62.88, 66.21 38.44, 67.87 63.18, -97.8 out-out out 13.2417 Saltbr-out 13.5751 HRD-out -80.45, 94.07 -71.75, -5.97 out-out-out SNCooo out-out ActLoopNT-out 10.8955 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.63, 129.76 APE9-dihe-na -71.09, 152.84 APE8-dihe-in -147.91, 130.69 APE8-rot-out 68.98 APE67-dihe-in -88.14, 9.58 -128.15, 23.18 APE12-dist-out 22.1448 APE11-dist-out 18.8445 APE10-dist-out 20.0096 APE9-dist-out 12.6573 None TPO170 TPO170 XRAY 3.02 0.217 0.288 D 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BA P50613 1 311 346.0 ANP:401 ATPlike Inactive DFGin 6.6665 15.0398 None -136.41, -179.13 75.36, -66.57 59.32, 16.33 291.11, 69.78 55.95, 32.69 out-out out 13.486 Saltbr-out 13.7543 HRD-in -65.3, -54.78 73.94, 0.68 out-out-out SNCooo out-out ActLoopNT-out 12.5504 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -74.63, 115.42 APE9-dihe-na -115.54, -2.31 APE8-dihe-out -56.05, -31.84 APE8-rot-out 157.42 APE67-dihe-in -63.34, -23.16 -66.49, -24.29 APE12-dist-out 18.0017 APE11-dist-out 20.1866 APE10-dist-out 16.0858 APE9-dist-out 11.4652 S164D,T170E None None XRAY 2.21 0.195 0.243 A 352.0 301.0 10 28 28 0 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BB P50613 3 310 346.0 ANP:402 ATPlike Inactive DFGin 6.5631 15.0836 None -126.22, 177.01 84.52, -73.28 65.77, 22.93 292.14, 76.04 47.33, 39.02 out-out out 13.6069 Saltbr-out 11.882 HRD-in -71.08, -53.54 74.78, -6.63 out-out-out SNCooo out-out ActLoopNT-out 12.9359 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.04, 115.32 APE9-dihe-na -115.04, 1.93 APE8-dihe-out -60.49, -32.76 APE8-rot-out 168.86 APE67-dihe-in -59.67, -24.77 -68.61, -28.01 APE12-dist-out 17.7792 APE11-dist-out 20.1865 APE10-dist-out 16.1566 APE9-dist-out 11.4157 S164D,T170E None None XRAY 2.21 0.195 0.243 B 352.0 298.0 10 28 28 0 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BC P50613 8 311 346.0 ANP:402 ATPlike Inactive DFGin 6.4512 15.3403 None -116.21, 176.78 77.39, -97.04 64.16, 26.01 311.61, 20.83 46.47, 58.36 out-out out 13.1044 Saltbr-out 12.1328 HRD-in -78.41, -55.45 77.67, -2.52 out-out-out SNCooo out-out ActLoopNT-out 12.9218 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.76 APE9-dihe-na -87.2, -35.35 APE8-dihe-out -49.87, -35.32 APE8-rot-in 271.7 APE67-dihe-in -63.34, -21.13 -58.67, -34.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9279 APE9-dist-out 10.9338 S164D,T170E None None XRAY 2.21 0.195 0.243 C 352.0 276.0 28 28 16 12 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BD P50613 9 311 346.0 ANP:402 ATPlike Inactive DFGin 5.1856 15.5294 None -119.23, -173.72 58.44, -119.7 56.58, 114.74 106.06, 59.9 70.5, -151.21 out-out out 13.0617 Saltbr-out 12.3535 HRD-in -80.52, -56.05 80.67, -8.56 out-out-out SNCooo out-out ActLoopNT-out 13.0554 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -29.49 APE9-dihe-na -113.47, -32.42 APE8-dihe-out -62.11, -27.52 APE8-rot-out 75.68 APE67-dihe-in -62.12, -24.79 -50.05, -35.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.1604 APE9-dist-out 11.1556 S164D,T170E None None XRAY 2.21 0.195 0.243 D 352.0 277.0 26 28 18 10 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9SB P50613 9 312 346.0 PE3:401,PE3:402,YPK:403 Allosteric,Allosteric,Type1 Inactive DFGin 6.6614 14.1368 None -136.72, -83.07 -78.7, 108.99 -96.75, 5.62 270.16, 92.75 -61.04, -22.45 in-in in 8.9693 Saltbr-in 2.9057 HRD-out -93.55, 75.1 -63.47, -8.59 in-in-out SNCiio in-out ActLoopNT-in 2.9575 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_niii APE10-dihe-na -131.56, -46.56 APE9-dihe-na -57.97, 167.59 APE8-dihe-in -92.57, 68.94 APE8-rot-out 164.5 APE67-dihe-out -70.3, -34.85 61.12, -49.62 APE12-dist-none 999.0 APE11-dist-in 12.5698 APE10-dist-in 6.7414 APE9-dist-in 4.0292 W132R,S164D,T170E None None XRAY 2.78 0.24 0.296 B 371.0 290.0 14 28 19 9 [[12, 295]] 1.0 8r9s Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 6O9L8 P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 7.7977 15.312 None -95.81, -101.98 -119.05, 160.07 -109.44, 53.11 290.95, 162.54 -72.96, -5.74 out-out out 10.6615 Saltbr-out 6.4895 HRD-out -97.79, 80.29 -81.32, 54.89 out-in-out SNCoio in-out ActLoopNT-in 3.4131 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -106.12, -175.8 APE9-dihe-na 68.22, 148.02 APE8-dihe-in -56.94, 134.18 APE8-rot-in 300.57 APE67-dihe-in -70.23, -40.86 -66.35, -19.39 APE12-dist-in 13.7088 APE11-dist-in 13.7987 APE10-dist-out 8.0601 APE9-dist-in 5.0875 None None None EM 7.2 999.0 999.0 8 346.0 299.0 1 28 28 0 [[12, 295]] 1.0 6o9l Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 7EGC8 P50613 13 310 346.0 No_ligand No_ligand Inactive DFGin 5.8793 15.5537 None -116.71, -58.02 -84.26, 100.6 -93.09, 48.78 282.6, 95.84 -80.87, -18.04 in-out in 8.7835 Saltbr-out 3.6643 HRD-out -108.84, 109.5 -77.51, -36.15 out-in-in SNCoii in-in ActLoopNT-in 3.4881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.54, -43.28 APE9-dihe-na -77.94, 146.2 APE8-dihe-in -56.64, 131.6 APE8-rot-in 308.37 APE67-dihe-in -104.38, -21.7 -62.92, -1.65 APE12-dist-in 12.8558 APE11-dist-in 12.6423 APE10-dist-in 6.9139 APE9-dist-in 4.4143 None None None EM 3.9 999.0 999.0 8 346.0 298.0 1 28 28 0 [[12, 295]] 1.0 7egc Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 7ENA8 P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.1587 16.9608 None -137.92, -69.17 -57.97, 126.4 -129.18, 16.9 254.87, 60.55 -63.02, -41.24 in-out in 9.4045 Saltbr-out 5.5294 HRD-out -89.6, 97.27 -59.31, -35.69 out-in-in SNCoii in-in ActLoopNT-in 3.1234 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.33, -53.74 APE9-dihe-na -65.5, 156.02 APE8-dihe-in -61.05, 144.25 APE8-rot-in 317.22 APE67-dihe-in -60.5, -45.43 -56.27, -38.88 APE12-dist-in 12.6274 APE11-dist-in 12.4607 APE10-dist-in 6.9122 APE9-dist-in 4.9505 None None None EM 4.07 999.0 999.0 8 346.0 299.0 1 28 28 0 [[12, 295]] 1.0 7ena Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8BYQ8 P50613 13 310 346.0 No_ligand No_ligand Inactive DFGin 6.883 15.2597 None -127.43, -46.68 -74.13, 79.99 -89.7, 31.43 293.88, 102.94 -76.34, -19.76 in-in in 8.5438 Saltbr-in 2.9389 HRD-out -110.14, 88.9 -51.71, -64.8 in-in-out SNCiio in-out ActLoopNT-in 2.8107 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -112.6, -33.42 APE9-dihe-na -72.79, 145.26 APE8-dihe-in -52.67, 130.55 APE8-rot-in 304.24 APE67-dihe-in -67.92, -7.8 -46.32, -42.89 APE12-dist-out 14.2994 APE11-dist-out 14.0136 APE10-dist-out 8.1268 APE9-dist-in 4.887 None None None EM 4.1 999.0 999.0 8 346.0 298.0 1 28 28 0 [[12, 295]] 1.0 8byq Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8GXQHI P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.1599 16.9603 None -137.77, -69.32 -57.85, 126.33 -129.21, 16.87 254.81, 60.64 -63.11, -41.19 in-na in 9.4051 Saltbr-na 999.0 HRD-out -89.54, 97.16 -59.39, -35.6 na-in-out SNCaio in-out ActLoopNT-in 3.1232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -64.78, -39.13 APE9-dihe-na -69.49, 155.25 APE8-dihe-in -63.89, 150.19 APE8-rot-out 50.1 APE67-dihe-in -62.44, -39.29 -58.88, -44.43 APE12-dist-in 12.6265 APE11-dist-in 12.532 APE10-dist-in 6.5278 APE9-dist-in 5.0977 K41A None None EM 5.04 999.0 999.0 HI 346.0 299.0 1 28 28 0 [[12, 295]] 1.0 8gxq Homo sapiens CMGC_CDK7_HUMAN CMGC 5.8e-77 266.6 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8GXSHI P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.1597 16.9609 None -137.74, -69.29 -57.91, 126.39 -129.28, 17.01 254.83, 60.43 -63.16, -41.26 in-na in 9.4047 Saltbr-na 999.0 HRD-out -89.55, 97.29 -59.32, -35.73 na-in-in SNCaii in-in ActLoopNT-in 3.1243 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.36, -53.7 APE9-dihe-na -65.65, 155.95 APE8-dihe-in -61.02, 136.47 APE8-rot-in 317.37 APE67-dihe-in -60.45, -41.25 -41.53, -50.25 APE12-dist-in 12.6262 APE11-dist-in 12.4608 APE10-dist-in 6.9131 APE9-dist-in 4.9494 K41A None None EM 4.16 999.0 999.0 HI 346.0 299.0 1 28 28 0 [[12, 295]] 1.0 8gxs Homo sapiens CMGC_CDK7_HUMAN CMGC 5.8e-77 266.6 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 6XD3J P50613 10 312 346.0 V0G:401 Type1 Inactive DFGin 6.4494 15.5688 None -83.3, -65.23 -79.84, 107.47 -100.97, 25.31 275.83, 77.7 -59.79, -36.45 in-out in 7.737 Saltbr-out 3.9352 HRD-out -83.2, 82.34 -68.79, 3.46 out-in-out SNCoio in-out ActLoopNT-in 2.8333 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -91.06, 77.29 APE9-dihe-na -174.12, 154.78 APE8-dihe-in -58.68, 146.66 APE8-rot-out 59.06 APE67-dihe-in -62.31, -31.09 -65.15, -41.16 APE12-dist-in 13.6186 APE11-dist-in 11.5253 APE10-dist-in 6.1269 APE9-dist-in 3.6285 None SEP164 SEP164 EM 3.3 999.0 999.0 J 349.0 298.0 5 28 28 0 [[12, 295]] 1.0 6xd3 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDKL2 CDKL2_HUMAN 4BBMA Q92772 1 308 493.0 TC0:60500 Type1 Inactive DFGin 7.1518 13.3139 None -116.66, 173.28 70.79, 69.66 -144.2, 73.96 44.17, 99.05 132.17, -46.5 out-none out 11.8482 Saltbr-none 999.0 HRD-in -64.8, -48.49 65.16, 11.9 none-out-out SNCnoo out-out ActLoopNT-out 10.2517 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -63.85, -51.88 APE9-dihe-na -56.62, -32.94 APE8-dihe-out -101.86, 5.45 APE8-rot-out 58.5 APE67-dihe-in -66.8, -17.87 -40.06, -47.54 APE12-dist-in 12.3155 APE11-dist-out 16.808 APE10-dist-out 19.4627 APE9-dist-out 9.3714 T159D,Y161E None None XRAY 2.0 0.244 0.269 A 331.0 306.0 2 28 28 0 [[4, 287]] 1.0 4bbm Homo sapiens CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CMGC CLK1 CLK1_HUMAN 6KHDA P49759 149 481 484.0 3NG:1000 Type1 Inactive DFGin 6.8618 14.4848 None -115.36, -74.37 -61.99, 112.36 -110.01, 19.25 292.55, 104.1 -59.59, -27.31 in-in in 8.7531 Saltbr-in 2.4552 HRD-in -79.61, -40.92 65.39, -11.49 in-in-out SNCiio in-out ActLoopNT-in 2.9802 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ioon APE10-dihe-na -162.31, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.78, 10.46 999.0, -15.39 APE12-dist-in 11.8684 APE11-dist-out 7.0432 APE10-dist-out 11.6347 APE9-dist-none 999.0 None None None XRAY 2.7 0.204 0.274 A 484.0 322.0 11 25 23 2 [[161, 477]] 1.0 6khd Homo sapiens CMGC_CLK1_HUMAN CMGC 8.2e-93 317.4 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CSNK2A2 CSK22_HUMAN 3E3BX P19784 1 334 350.0 CCK:351 Type1 Inactive DFGin 7.9316 16.543 None -60.71, 173.45 58.68, 153.51 -167.77, 24.29 292.11, 94.72 -71.5, -16.51 in-in in 9.9668 Saltbr-in 3.1757 HRD-in -22.7, -49.66 82.48, 4.05 in-in-in SNCiii in-in ActLoopNT-in 3.5364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.37, 167.02 APE9-dihe-na 87.1, -164.84 APE8-dihe-in -118.3, 158.91 APE8-rot-in 284.14 APE67-dihe-in -147.62, -14.08 -66.97, 28.66 APE12-dist-in 13.0394 APE11-dist-in 10.8233 APE10-dist-in 6.2359 APE9-dist-in 3.6473 None None None XRAY 3.2 0.268 0.274 X 339.0 334.0 0 27 27 0 [[40, 325]] 1.0 3e3b Homo sapiens CMGC_CSNK2A2_HUMAN CMGC 8.1e-70 241.3 1.0 301.0 301.0 175 176 177 179 181 69 82 86 154 156 155 157.0 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC DYRK1A DYR1A_HUMAN 6UIPA Q13627 131 479 763.0 Q8J:501 Type1 Inactive DFGin 7.3285 15.2923 None -128.98, -33.2 -83.24, -86.92 68.74, 42.73 287.01, 105.17 -106.11, -43.86 in-in in 8.6072 Saltbr-in 2.4441 HRD-in -69.31, -45.72 68.49, 1.14 in-in-in SNCiii in-in ActLoopNT-in 3.0339 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.27, -51.33 APE9-dihe-na -84.83, 157.96 APE8-dihe-in -67.65, 136.35 APE8-rot-in 301.98 APE67-dihe-in -59.01, -29.0 -52.09, -48.51 APE12-dist-in 12.5097 APE11-dist-in 10.8491 APE10-dist-in 6.989 APE9-dist-in 3.2296 None PTR321 PTR321 XRAY 3.7 0.272 0.29 A 361.0 345.0 4 25 25 0 [[159, 479]] 1.0 6uip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT2A Q13627 134 480 763.0 A1IE6:501 Type1 Inactive DFGin 7.574 15.8948 None -123.41, -159.52 69.59, -109.27 67.33, -3.52 296.76, 96.58 -76.19, -5.59 in-in in 9.1443 Saltbr-in 3.2983 HRD-in -61.34, -38.17 66.08, 9.45 in-out-out SNCioo out-out ActLoopNT-out 4.1136 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -106.57, 172.34 APE9-dihe-na 65.66, 156.83 APE8-dihe-in -69.73, 153.42 APE8-rot-out 183.57 APE67-dihe-in -64.1, -34.34 -62.54, -50.05 APE12-dist-in 11.1649 APE11-dist-in 11.8684 APE10-dist-in 7.9234 APE9-dist-in 3.3634 None PTR321 PTR321 XRAY 2.9 0.212 0.235 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9ft2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT3A Q13627 134 480 763.0 A1IE7:501 Type1 Inactive DFGin 7.5595 15.6952 None -120.59, 174.62 87.74, -111.53 67.1, 10.68 308.34, 93.78 -70.59, -9.71 in-in in 8.8414 Saltbr-in 2.944 HRD-in -61.2, -47.31 80.25, -0.32 in-out-out SNCioo out-out ActLoopNT-out 4.0536 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.45, 165.76 APE9-dihe-na 76.29, 154.85 APE8-dihe-in -77.87, 145.0 APE8-rot-out 181.65 APE67-dihe-in -62.64, -27.73 -60.42, -45.99 APE12-dist-in 11.1415 APE11-dist-in 12.0085 APE10-dist-in 7.9543 APE9-dist-in 3.1564 None PTR321 PTR321 XRAY 2.7 0.196 0.23 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9ft3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT4A Q13627 134 480 763.0 A1IFJ:501 Type1 Inactive DFGin 7.628 15.7669 None -120.71, -156.86 61.01, -103.63 67.38, -3.25 294.05, 97.87 -71.86, -4.64 in-in in 9.0659 Saltbr-in 3.1765 HRD-in -62.39, -36.73 64.58, 13.09 in-out-out SNCioo out-out ActLoopNT-out 4.0281 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.4, 173.83 APE9-dihe-na 66.37, 159.49 APE8-dihe-in -70.35, 150.45 APE8-rot-out 182.43 APE67-dihe-in -65.5, -29.58 -61.56, -47.55 APE12-dist-in 11.2318 APE11-dist-in 11.9502 APE10-dist-in 7.9178 APE9-dist-in 3.4052 None PTR321 PTR321 XRAY 3.0 0.203 0.237 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9ft4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FT6A Q13627 134 480 763.0 A1IE8:501 Type1 Inactive DFGin 7.5847 15.8164 None -126.75, 170.06 89.43, -106.36 68.66, 5.72 299.38, 96.13 -75.78, -8.95 in-in in 9.146 Saltbr-in 3.3387 HRD-in -60.11, -40.88 70.11, 5.43 in-out-out SNCioo out-out ActLoopNT-out 3.9393 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.56, 172.59 APE9-dihe-na 68.31, 156.56 APE8-dihe-in -68.23, 150.78 APE8-rot-out 177.43 APE67-dihe-in -63.38, -34.6 -61.07, -48.82 APE12-dist-in 11.1848 APE11-dist-in 11.9025 APE10-dist-in 7.8766 APE9-dist-in 3.4151 None PTR321 PTR321 XRAY 3.0 0.209 0.25 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9ft6 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 9FUFA Q13627 134 480 763.0 A1IFO:501 Type1 Inactive DFGin 7.6694 15.7431 None -124.23, -170.08 74.82, -105.33 66.79, 7.03 297.99, 97.28 -82.54, -3.73 in-in in 9.004 Saltbr-in 3.0075 HRD-in -63.73, -39.36 69.07, 9.77 in-out-out SNCioo out-out ActLoopNT-out 4.1118 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.16, 171.47 APE9-dihe-na 67.5, 156.88 APE8-dihe-in -71.53, 145.53 APE8-rot-out 186.89 APE67-dihe-in -63.53, -27.94 -60.87, -45.06 APE12-dist-in 11.1936 APE11-dist-in 11.939 APE10-dist-in 7.9049 APE9-dist-in 3.3087 None PTR321 PTR321 XRAY 2.7 0.21 0.232 A 361.0 342.0 5 25 25 0 [[159, 479]] 1.0 9fuf Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 9KQYA Q92630 151 537 601.0 No_ligand No_ligand Inactive DFGin 6.5585 15.3057 None -118.46, -58.2 -76.39, 93.69 -100.84, 14.42 280.8, 85.79 -66.94, -30.92 in-in in 8.8424 Saltbr-in 2.9544 HRD-in -69.15, -42.93 69.8, -4.72 in-in-in SNCiii in-in ActLoopNT-in 2.7465 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.16, 173.73 APE9-dihe-na 69.18, 145.61 APE8-dihe-in -65.57, 148.39 APE8-rot-in 308.71 APE67-dihe-in -62.63, -39.04 -60.44, -42.14 APE12-dist-in 13.0235 APE11-dist-in 11.6538 APE10-dist-in 7.1331 APE9-dist-in 3.1497 None PTR382 PTR382 XRAY 3.2 0.233 0.276 A 407.0 387.0 0 25 25 0 [[222, 535]] 1.0 9kqy Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 8HLTB Q92630 151 537 601.0 XSE:60501 Type1 Inactive DFGin 6.6774 15.1725 None -123.1, -45.42 -92.76, 76.97 -82.13, 19.07 287.19, 77.16 -64.05, -27.16 in-in in 8.9659 Saltbr-in 2.9746 HRD-in -75.54, -44.65 72.51, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.7835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.69, 168.46 APE9-dihe-na 73.66, 156.43 APE8-dihe-in -77.8, 146.18 APE8-rot-in 309.51 APE67-dihe-in -59.07, -35.58 -50.16, -47.35 APE12-dist-in 12.9871 APE11-dist-in 11.6227 APE10-dist-in 7.106 APE9-dist-in 3.1243 None PTR382 PTR382 XRAY 2.8 0.213 0.267 B 393.0 387.0 0 25 25 0 [[222, 535]] 1.0 8hlt Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 9KQYB Q92630 151 537 601.0 A1L6I:60501 Type1 Inactive DFGin 6.8416 15.4099 None -119.38, -59.48 -76.49, 94.24 -100.04, 16.54 278.63, 76.93 -66.67, -33.1 in-in in 8.7342 Saltbr-in 2.8484 HRD-in -67.3, -42.38 69.63, -4.95 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 173.43 APE9-dihe-na 69.88, 144.62 APE8-dihe-in -65.72, 149.7 APE8-rot-in 302.89 APE67-dihe-in -61.87, -38.72 -60.58, -43.15 APE12-dist-in 12.5365 APE11-dist-in 11.0539 APE10-dist-in 6.6176 APE9-dist-in 3.2336 None PTR382 PTR382 XRAY 3.2 0.233 0.276 B 407.0 387.0 0 25 25 0 [[222, 535]] 1.0 9kqy Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC GSK3B GSK3B_HUMAN 8QJIA P49841 36 381 420.0 VNG:401 Type1 Inactive DFGin 6.9495 14.1959 None -92.57, -90.5 -72.82, 155.73 -144.36, 17.02 276.05, 102.26 -73.85, -19.5 in-in in 8.3845 Saltbr-in 2.6943 HRD-in -65.27, -43.08 63.67, 22.78 in-in-out SNCiio in-out ActLoopNT-in 3.34 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.54, 179.17 APE9-dihe-na 65.4, 161.24 APE8-dihe-in -68.89, 150.02 APE8-rot-out 175.4 APE67-dihe-in -64.21, -18.12 -58.7, -47.99 APE12-dist-in 13.3857 APE11-dist-in 12.0024 APE10-dist-in 7.07 APE9-dist-in 3.4473 None PTR216 PTR216 XRAY 3.02 0.253 0.289 A 364.0 340.0 6 27 27 0 [[56, 340]] 1.0 8qji Homo sapiens CMGC_GSK3B_HUMAN CMGC 2e-70 243.5 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK10 MK10_HUMAN 3OXIA P53779 46 400 464.0 SYY:60001 Type1 Inactive DFGin 4.7853 13.3158 None -65.65, -67.29 -149.24, -142.55 -154.51, 112.55 32.12, 89.18 -52.06, 999.0 in-in in 9.8126 Saltbr-in 2.8472 HRD-in -69.6, -55.6 74.47, -18.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.07 APE8-dihe-in -67.1, 115.71 APE8-rot-in 310.72 APE67-dihe-in -75.18, -9.96 -113.13, 12.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4824 None None None XRAY 2.2 0.232 0.275 A 362.0 322.0 19 27 12 15 [[64, 359]] 1.0 3oxi Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 3PTGA P53779 46 401 464.0 932:60001 Type1 Inactive DFGin 3.7132 13.1579 None -76.5, -95.65 -85.65, -153.0 -174.62, 83.6 38.12, 37.79 -80.26, -75.99 in-in in 8.9492 Saltbr-in 2.713 HRD-in -82.38, -47.37 67.19, -16.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -33.68 APE8-dihe-out 167.39, -0.43 APE8-rot-out 180.66 APE67-dihe-in -48.92, -26.13 -62.89, -39.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8039 None None None XRAY 2.43 0.247 0.316 A 363.0 340.0 16 27 14 13 [[64, 359]] 1.0 3ptg Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 1PMVA P53779 45 400 464.0 537:501 Type1 Inactive DFGin 4.2247 14.7388 None -81.65, -103.82 -56.07, 179.4 -108.34, 6.78 292.4, 71.45 88.17, -161.99 out-out out 10.0434 Saltbr-out 5.5021 HRD-in -44.57, -73.88 76.33, -1.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -55.4, 164.21 APE9-dihe-na -103.96, 46.79 APE8-dihe-in -57.98, 139.58 APE8-rot-in 313.89 APE67-dihe-in -60.79, -25.59 -166.19, 12.11 APE12-dist-out 19.3858 APE11-dist-in 13.7304 APE10-dist-out 15.5802 APE9-dist-out 12.2546 None None None XRAY 2.5 0.222 0.282 A 364.0 347.0 5 27 22 5 [[64, 359]] 1.0 1pmv Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 8VS0A P53779 45 400 464.0 A1ACT:501 Type1 Inactive DFGin 4.0117 14.6105 None -113.83, -24.3 -131.4, -10.59 66.04, -11.26 300.28, 122.45 85.3, -162.24 out-out out 10.0307 Saltbr-out 5.9637 HRD-in -58.98, -68.6 78.5, 4.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.17, 144.09 APE9-dihe-na -84.41, 142.6 APE8-dihe-in -87.18, 136.96 APE8-rot-in 297.81 APE67-dihe-in -68.04, -18.46 -128.93, 1.97 APE12-dist-out 21.4943 APE11-dist-out 16.3645 APE10-dist-out 16.3116 APE9-dist-out 11.3764 None None None XRAY 2.46 0.198 0.25 A 464.0 346.0 5 27 22 5 [[64, 359]] 1.0 8vs0 Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK11 MK11_HUMAN 3GC9A Q15759 3 348 364.0 B45:365 Type1 Inactive DFGin 4.5577 14.0834 None -99.4, 135.63 55.61, 168.55 -126.62, 27.34 309.47, 109.49 93.22, 8.24 in-out in 9.6686 Saltbr-out 4.0554 HRD-in -70.45, -55.0 82.48, -18.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.74 APE8-dihe-in -70.43, 137.59 APE8-rot-out 173.62 APE67-dihe-in -61.21, -17.49 -105.03, 7.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6952 C119S,C162S None None XRAY 2.05 0.224 0.275 A 370.0 335.0 11 25 14 11 [[24, 308]] 1.0 3gc9 Homo sapiens CMGC_MAPK11_HUMAN CMGC 1.6e-82 283.1 4.0 301.0 298.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 11
CMGC MAPK14 MK14_HUMAN 4E6AA Q16539 4 351 360.0 0O9:500 Allosteric Inactive DFGin 7.8292 16.7355 None -116.35, 173.04 63.5, -177.46 -171.04, 999.0 277.86, 82.56 999.0, 999.0 in-in in 9.4716 Saltbr-in 2.9275 HRD-in -64.73, -56.61 86.56, -18.31 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -58.14, -22.79 999.0, 21.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.09 0.224 0.273 A 360.0 324.0 23 25 9 16 [[24, 308]] 1.0 4e6a Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E6CA Q16539 4 351 360.0 0O8:500 Allosteric Inactive DFGin 7.12 15.5419 None -107.87, 169.94 71.07, 48.65 -62.86, 999.0 316.7, 83.95 999.0, 999.0 in-in in 9.053 Saltbr-in 3.1301 HRD-in -64.38, -54.16 91.01, -29.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.63 APE8-rot-out 211.4 APE67-dihe-in -58.37, -26.81 -122.63, 18.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.22 0.292 A 360.0 330.0 18 25 10 15 [[24, 308]] 1.0 4e6c Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5N67A Q16539 5 353 360.0 8ON:401 Allosteric Inactive DFGin 6.8653 15.6092 None -128.23, -179.23 57.11, 61.45 -58.51, 999.0 306.28, 87.84 999.0, 999.0 in-in in 9.4444 Saltbr-in 3.0167 HRD-in -67.68, -53.37 80.76, -14.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.97 APE8-dihe-out -66.09, -43.78 APE8-rot-in 291.76 APE67-dihe-in -63.81, -23.7 -63.35, -24.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7672 None None None XRAY 1.9 0.191 0.222 A 360.0 327.0 22 25 11 14 [[24, 308]] 1.0 5n67 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 8X3MA Q16539 4 353 360.0 B8Z:401 Allosteric Inactive DFGin 7.7119 16.8556 None -115.94, 168.03 71.62, -88.99 88.0, 131.81 286.06, 88.99 -70.61, 105.76 in-in in 9.6027 Saltbr-in 3.0578 HRD-in -66.17, -53.58 79.95, -8.82 in-out-out SNCioo out-out ActLoopNT-out 10.5579 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.62, 133.04 APE9-dihe-na -62.46, -10.4 APE8-dihe-out -67.81, -17.48 APE8-rot-out 51.83 APE67-dihe-in -60.97, -25.8 -116.4, -18.75 APE12-dist-out 22.0398 APE11-dist-out 24.1061 APE10-dist-out 18.4386 APE9-dist-out 11.7912 None None None XRAY 1.85 0.183 0.226 A 365.0 350.0 0 25 25 0 [[24, 308]] 1.0 8x3m Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4DLIA Q16539 5 354 360.0 IRG:401,IRG:402 Allosteric,Allosteric Inactive DFGin 9.8147 11.8562 None -104.36, 150.39 -73.0, -47.15 -137.92, 126.59 314.79, 100.08 -44.68, 999.0 in-in in 9.4387 Saltbr-in 2.8448 HRD-in -68.95, -53.08 77.7, -11.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 123.1 APE9-dihe-na -70.95, 129.15 APE8-dihe-out -52.5, -43.49 APE8-rot-in 288.97 APE67-dihe-in -64.32, -23.54 -55.51, -29.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0955 None None None XRAY 1.91 0.216 0.255 A 360.0 334.0 16 25 13 12 [[24, 308]] 1.0 4dli Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EH4A Q16539 4 354 360.0 IRG:401,0OL:402 Allosteric,Type1 Inactive DFGin 10.8466 12.1969 None -91.43, 145.17 -57.64, -47.01 -148.78, 133.96 289.87, 102.95 -106.02, 178.5 in-in in 9.3455 Saltbr-in 3.5333 HRD-in -75.34, -49.4 79.8, -22.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 89.91 APE9-dihe-na -88.64, 150.01 APE8-dihe-out -60.61, -41.02 APE8-rot-in 254.43 APE67-dihe-in -62.83, -20.65 -63.82, -26.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.1023 APE9-dist-out 11.2223 None None None XRAY 2.5 0.234 0.317 A 360.0 337.0 14 25 15 10 [[24, 308]] 1.0 4eh4 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3C5UA Q16539 4 352 360.0 P41:361,P41:362 Allosteric,Type1 Inactive DFGin 5.9263 14.6107 None -79.99, -52.08 -111.86, 147.19 165.52, 164.69 70.95, 141.36 -178.3, -57.28 in-in in 9.4101 Saltbr-in 2.8949 HRD-in -58.08, -50.48 77.9, -18.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 89.15 APE9-dihe-na -79.53, 169.16 APE8-dihe-in -115.39, 178.62 APE8-rot-out 194.24 APE67-dihe-out 106.71, -27.43 -78.01, -142.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.0025 APE9-dist-out 13.5624 None None None XRAY 2.8 0.263 0.296 A 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 3c5u Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E5AX Q16539 3 353 360.0 No_ligand No_ligand Inactive DFGin 7.4271 16.6777 None -111.06, 176.17 53.13, 71.95 -70.18, 999.0 294.84, 64.48 999.0, 999.0 in-in in 9.576 Saltbr-in 3.5066 HRD-in -71.06, -54.61 88.3, -21.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 105.51 APE8-dihe-in -65.33, 145.05 APE8-rot-out 181.03 APE67-dihe-in -68.36, -17.57 -107.7, 17.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7943 W197A None None XRAY 1.87 0.219 0.253 X 360.0 332.0 19 25 11 14 [[24, 308]] 1.0 4e5a Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.7e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OD6X Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.1693 14.5472 None -107.32, -35.37 -122.54, 110.88 -101.89, 179.03 304.51, 65.36 116.69, -52.36 in-in in 9.7055 Saltbr-in 3.5749 HRD-out -70.82, 103.82 -92.19, 25.39 in-in-out SNCiio in-out ActLoopNT-in 2.9041 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -86.05, 124.21 APE9-dihe-na 179.03, 165.34 APE8-dihe-in -50.68, 120.55 APE8-rot-in 316.14 APE67-dihe-in -54.18, -37.51 -81.72, -17.02 APE12-dist-in 10.2458 APE11-dist-out 6.7415 APE10-dist-out 9.7315 APE9-dist-out 7.1949 Y323T None None XRAY 2.682 0.215 0.283 X 360.0 344.0 5 25 25 0 [[24, 308]] 1.0 3od6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OEFX Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 4.9023 12.1341 None -108.05, 167.45 -157.07, -159.47 61.31, 35.4 325.61, 112.03 64.1, 24.95 in-in in 8.824 Saltbr-in 2.7137 HRD-in -68.42, -53.79 78.26, -14.32 in-out-none SNCion out-none ActLoopNT-out 17.9811 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.36 APE8-rot-in 260.2 APE67-dihe-in -60.02, -22.95 -112.04, 6.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 Y323F None None XRAY 1.6 0.187 0.221 X 360.0 334.0 14 25 14 11 [[24, 308]] 1.0 3oef Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ODYX Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.2927 14.9518 None -99.56, -49.69 -113.79, 73.73 -150.67, 152.99 55.1, 98.03 53.69, 11.06 out-out out 11.8635 Saltbr-out 8.8242 HRD-out -75.99, 166.59 -145.03, -3.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 113.54 APE9-dihe-na -84.24, -15.35 APE8-dihe-out -79.73, -37.47 APE8-rot-in 312.81 APE67-dihe-in -57.52, -26.46 -53.29, -32.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9259 APE9-dist-out 11.0075 Y323Q None None XRAY 2.2 0.238 0.304 X 360.0 321.0 29 25 15 10 [[24, 308]] 1.0 3ody Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MGYA Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.8489 15.4078 None -96.6, 163.16 144.18, -87.53 -41.62, 999.0 25.94, 59.9 999.0, 999.0 in-in in 9.8726 Saltbr-in 2.9683 HRD-in -64.11, -58.21 85.85, 0.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 165.22 APE8-rot-out 214.38 APE67-dihe-in -69.5, -24.6 -110.92, 8.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.243 0.291 A 360.0 329.0 19 25 10 15 [[24, 308]] 1.0 3mgy Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4E5BA Q16539 4 351 360.0 No_ligand No_ligand Inactive DFGin 7.7496 16.4477 None -109.02, 158.46 31.08, 83.24 -71.5, 999.0 299.95, 31.84 999.0, 999.0 in-in in 9.2652 Saltbr-in 2.8145 HRD-in -56.8, -65.03 90.55, -13.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.6, -23.21 999.0, 23.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.237 0.279 A 360.0 324.0 23 25 9 16 [[24, 308]] 1.0 4e5b Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ODZX Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.0644 15.3431 None -127.95, -15.93 -113.67, 56.52 -144.01, 156.75 54.25, 120.62 60.75, 23.2 out-out out 11.618 Saltbr-out 9.0277 HRD-out -65.57, 130.15 -105.04, 19.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.07 APE9-dihe-na -94.07, 5.61 APE8-dihe-in -177.03, 113.52 APE8-rot-out 172.92 APE67-dihe-in -61.07, -28.1 -95.52, 3.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.3127 APE9-dist-out 12.5093 Y323R None None XRAY 2.3 0.223 0.282 X 360.0 335.0 15 25 15 10 [[24, 308]] 1.0 3odz Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5ETCA Q16539 1 352 360.0 No_ligand No_ligand Inactive DFGin 7.9268 17.5065 None -109.69, 177.11 57.89, 82.77 -103.25, -87.08 272.53, 90.11 -31.01, -89.71 in-out in 9.7017 Saltbr-out 3.6009 HRD-in -68.38, -45.82 79.56, -12.49 out-out-out SNCooo out-out ActLoopNT-out 10.994 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -140.41, 139.5 APE9-dihe-na -66.28, -17.2 APE8-dihe-out -69.09, -9.59 APE8-rot-out 56.2 APE67-dihe-in -64.25, -22.37 -125.41, -16.44 APE12-dist-out 21.1759 APE11-dist-out 23.1029 APE10-dist-out 17.3278 APE9-dist-out 11.8982 None None None XRAY 2.422 0.197 0.242 A 363.0 352.0 0 25 25 0 [[24, 308]] 1.0 5etc Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WFCA Q16539 5 351 360.0 No_ligand No_ligand Inactive DFGin 7.6408 16.6525 None -118.35, 179.66 63.95, -92.6 123.2, 999.0 266.78, 80.69 999.0, 999.0 in-out in 9.5424 Saltbr-out 3.6831 HRD-in -80.8, -27.0 48.37, 14.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -129.45, 133.38 APE9-dihe-na -57.59, -22.46 APE8-dihe-out -57.94, -20.68 APE8-rot-out 53.19 APE67-dihe-in -65.99, -19.65 -113.55, -17.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7898 None None None XRAY 2.3 0.213 0.297 A 366.0 340.0 5 25 20 5 [[24, 308]] 1.0 1wfc Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MH0A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 8.4153 16.8838 None -94.37, 151.84 67.81, 17.94 -52.66, 126.59 999.0, 999.0 86.82, 1.89 in-in in 9.3128 Saltbr-in 2.9134 HRD-in -65.91, -50.91 79.65, -20.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.01 APE8-rot-out 35.18 APE67-dihe-in -59.42, -23.13 -101.48, 7.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169A None None XRAY 2.0 0.232 0.28 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3mh0 Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.1e-83 287.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3IW6A Q16539 4 353 360.0 PP0:361 Type1 Inactive DFGin 10.6593 12.8022 None -107.45, 146.07 -62.15, -52.96 -135.84, 140.51 306.3, 96.66 -100.47, -175.96 in-in in 8.9094 Saltbr-in 2.7027 HRD-in -68.9, -58.44 84.06, -12.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 89.13 APE9-dihe-na -68.25, 143.74 APE8-dihe-out -81.14, -28.36 APE8-rot-out 119.31 APE67-dihe-in -61.88, -28.19 -54.39, -28.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.738 APE9-dist-out 12.6069 C119S,C162S,A172C,F327L None None XRAY 2.1 0.213 0.273 A 360.0 337.0 13 25 14 11 [[24, 308]] 1.0 3iw6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3IW7A Q16539 4 352 360.0 IPK:361 Type1 Inactive DFGin 10.7835 12.9675 None -101.08, 142.65 -64.35, -57.15 -132.52, 130.32 305.61, 101.42 -90.75, 171.73 in-in in 9.027 Saltbr-in 3.0854 HRD-in -64.07, -57.02 86.6, -16.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.97 APE8-dihe-out -80.2, 2.17 APE8-rot-out 181.73 APE67-dihe-in -62.05, -22.02 -116.3, -9.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0592 C119S,C162S,A172C,F327L None None XRAY 2.4 0.203 0.282 A 360.0 335.0 14 25 13 12 [[24, 308]] 1.0 3iw7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2BAQA Q16539 5 351 360.0 PQB:401 Type1 Inactive DFGin 10.3272 11.741 None -89.31, 142.2 -51.16, -47.94 -140.37, 153.62 295.29, 101.84 -84.84, -141.61 in-in in 8.4503 Saltbr-in 2.9936 HRD-in -54.23, -50.45 81.43, -10.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -91.51, 119.1 APE9-dihe-na -74.33, 131.38 APE8-dihe-out -51.32, -39.83 APE8-rot-in 282.97 APE67-dihe-in -50.36, -10.98 -69.35, -26.54 APE12-dist-none 999.0 APE11-dist-in 10.1777 APE10-dist-out 10.48 APE9-dist-out 11.6645 V30I None CSS162 XRAY 2.8 0.222 0.296 A 365.0 330.0 17 25 16 9 [[24, 308]] 1.0 2baq Homo sapiens CMGC_MAPK14_HUMAN CMGC 4e-85 291.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WBOA Q16539 4 354 360.0 2CH:1355 Type1 Inactive DFGin 7.5035 16.9555 None -102.06, -162.61 -36.66, 129.23 -76.33, 147.94 286.93, 61.58 -66.99, 104.73 in-in in 9.724 Saltbr-in 2.7727 HRD-in -73.99, -52.37 82.98, -14.31 in-out-out SNCioo out-out ActLoopNT-out 10.5915 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.64, 132.01 APE9-dihe-na -58.44, -25.39 APE8-dihe-out -53.56, -33.51 APE8-rot-out 45.91 APE67-dihe-in -69.56, -19.55 -106.13, -10.44 APE12-dist-out 21.7087 APE11-dist-out 23.849 APE10-dist-out 18.1619 APE9-dist-out 11.712 None None None XRAY 2.16 0.167 0.22 A 360.0 351.0 0 25 25 0 [[24, 308]] 1.0 1wbo Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5OMGA Q16539 4 353 360.0 9Y8:402 Type1 Inactive DFGin 10.9259 12.75 None -99.59, 155.64 -73.45, -50.39 -143.59, 137.7 303.2, 98.46 -92.47, -157.32 in-in in 9.0658 Saltbr-in 3.1972 HRD-in -65.81, -53.84 75.16, -16.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 84.11 APE9-dihe-na -56.7, 137.85 APE8-dihe-out -66.22, -35.89 APE8-rot-out 184.11 APE67-dihe-in -59.63, -25.96 -58.79, -27.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.0608 APE9-dist-out 11.9487 None None None XRAY 2.0 0.186 0.245 A 360.0 337.0 13 25 15 10 [[24, 308]] 1.0 5omg Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9YTYA Q16539 4 353 360.0 A1BB6:402 Type1 Inactive DFGin 4.6111 13.1622 None -120.16, 162.46 56.72, 51.46 -84.98, 999.0 26.65, 85.72 999.0, 999.0 in-in in 9.4594 Saltbr-in 2.8615 HRD-in -70.78, -49.19 75.68, -17.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.8 APE8-dihe-out -66.34, -34.75 APE8-rot-in 298.99 APE67-dihe-in -64.81, -21.23 -60.57, -20.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7554 None None None XRAY 2.25 0.211 0.254 A 360.0 336.0 14 25 11 14 [[24, 308]] 1.0 9yty Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUDA Q16539 4 354 360.0 N3F:361 Type1 Inactive DFGin 10.8012 12.5528 None -93.66, 153.34 -68.51, -47.3 -136.82, 128.38 301.98, 103.1 -95.02, -166.54 in-in in 9.269 Saltbr-in 3.5549 HRD-in -63.42, -58.28 80.41, -12.58 in-out-out SNCioo out-out ActLoopNT-out 20.8014 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.75 APE9-dihe-na -76.37, 136.79 APE8-dihe-out -65.47, -38.0 APE8-rot-in 295.71 APE67-dihe-in -57.05, -26.46 -56.48, -28.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.7622 APE9-dist-out 12.6517 None None None XRAY 2.0 0.234 0.278 A 360.0 345.0 6 25 19 6 [[24, 308]] 1.0 3qud Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUEA Q16539 5 353 360.0 3FF:362 Type1 Inactive DFGin 10.6415 12.3386 None -82.41, 155.86 -75.27, -54.23 -130.98, 134.23 308.77, 88.25 -97.08, -170.31 in-in in 8.9604 Saltbr-in 2.6567 HRD-in -64.83, -54.13 86.66, -27.06 in-out-out SNCioo out-out ActLoopNT-out 21.2792 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 66.84 APE9-dihe-na -77.78, 135.56 APE8-dihe-out -48.89, -54.16 APE8-rot-in 280.74 APE67-dihe-in -53.38, -25.8 -51.95, -34.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1952 APE9-dist-out 11.3927 None None None XRAY 2.7 0.23 0.311 A 360.0 343.0 6 25 19 6 [[24, 308]] 1.0 3que Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZSIA Q16539 6 352 360.0 52P:1000 Type1 Inactive DFGin 10.4689 12.2756 None -99.24, 157.46 -83.12, -44.9 -141.74, 118.5 319.2, 96.5 -93.21, -169.85 in-in in 8.8878 Saltbr-in 3.0614 HRD-in -68.1, -49.59 77.07, -12.99 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.82 APE8-rot-in 291.48 APE67-dihe-in -55.25, -30.12 -56.65, -32.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.234 0.271 A 362.0 326.0 21 25 12 13 [[24, 308]] 1.0 3zsi Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9MHBA Q16539 4 353 360.0 A1BLA:401 Type1 Inactive DFGin 7.102 16.2712 None -117.98, 165.25 51.74, 50.71 -38.59, 999.0 301.84, 11.59 999.0, 999.0 in-in in 9.4983 Saltbr-in 2.8857 HRD-in -70.02, -56.7 79.98, -12.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -51.26 APE9-dihe-na -76.26, 128.02 APE8-dihe-out -60.23, -38.8 APE8-rot-in 294.53 APE67-dihe-in -63.02, -23.59 -57.69, -25.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5631 None None CME162 XRAY 1.65 0.174 0.202 A 362.0 337.0 13 25 12 13 [[24, 308]] 1.0 9mhb Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FC1X Q16539 5 353 360.0 52P:362 Type1 Inactive DFGin 7.1239 15.1868 None -126.14, -173.97 53.21, -144.46 158.6, 119.78 279.97, 109.61 999.0, 999.0 in-in in 9.0296 Saltbr-in 2.6197 HRD-in -59.7, -53.23 81.3, -16.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -128.32, 135.87 APE9-dihe-na -60.12, -21.5 APE8-dihe-out -62.23, -25.4 APE8-rot-out 50.45 APE67-dihe-in -63.14, -19.02 -109.22, -16.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2558 None None None XRAY 2.4 0.204 0.251 X 366.0 334.0 13 25 17 8 [[24, 308]] 1.0 3fc1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3BV2A Q16539 5 351 360.0 P38:501 Type1 Inactive DFGin 10.9192 11.9511 None -130.49, -172.23 -144.15, 148.34 64.11, 33.68 315.43, 116.87 -55.63, 125.6 in-in in 9.1734 Saltbr-in 2.72 HRD-in -59.8, -67.17 84.25, -8.03 in-out-out SNCioo out-out ActLoopNT-out 21.9505 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 115.36 APE8-dihe-out -57.65, -17.83 APE8-rot-out 225.25 APE67-dihe-in -64.72, -27.84 -71.88, -20.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1463 None None None XRAY 2.4 0.209 0.263 A 366.0 337.0 10 25 15 10 [[24, 308]] 1.0 3bv2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OCGA Q16539 4 352 360.0 OCG:361 Type1 Inactive DFGin 5.2198 14.3908 None -93.64, -75.59 -102.1, 63.24 -58.64, -80.69 42.2, 96.84 -84.43, 26.24 in-in in 9.0686 Saltbr-in 2.6197 HRD-in -63.56, -51.33 77.03, -20.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 103.73 APE8-rot-out 176.87 APE67-dihe-in -64.6, -19.08 -164.89, -32.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.214 0.27 A 366.0 336.0 13 25 12 13 [[24, 308]] 1.0 3ocg Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2GFSA Q16539 5 352 360.0 PQB:361 Type1 Inactive DFGin 7.4894 16.1685 None -132.16, -175.45 50.97, 60.34 -61.94, 999.0 284.15, 70.88 999.0, 999.0 in-in in 9.1388 Saltbr-in 2.7264 HRD-in -67.49, -53.73 80.94, -11.52 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -137.15, 132.57 APE9-dihe-na -61.35, -21.8 APE8-dihe-out -55.56, -23.97 APE8-rot-out 51.68 APE67-dihe-in -64.89, -19.57 -114.73, -17.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0158 None None None XRAY 1.752 0.206 0.239 A 372.0 344.0 4 25 21 4 [[24, 308]] 1.0 2gfs Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FMLA Q16539 4 352 360.0 FML:361 Type1 Inactive DFGin 7.3213 16.1677 None -113.5, 169.93 78.68, -95.68 95.06, 999.0 286.66, 90.12 999.0, 999.0 in-in in 9.4074 Saltbr-in 2.6446 HRD-in -67.48, -49.5 80.29, -18.01 in-out-out SNCioo out-out ActLoopNT-out 10.2813 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.68, 134.28 APE9-dihe-na -62.37, -13.16 APE8-dihe-out -68.44, -18.97 APE8-rot-out 59.25 APE67-dihe-in -63.75, -24.61 -116.53, -16.96 APE12-dist-out 21.7069 APE11-dist-out 23.7308 APE10-dist-out 17.9821 APE9-dist-out 11.9013 None None None XRAY 2.1 0.216 0.245 A 372.0 342.0 7 25 24 1 [[24, 308]] 1.0 3fml Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3FSKA Q16539 5 352 360.0 RO6:450 Type1 Inactive DFGin 7.5793 16.3094 None -136.71, -175.6 44.08, 65.21 -58.68, 999.0 291.46, 58.68 999.0, 999.0 in-in in 9.2711 Saltbr-in 2.5853 HRD-in -71.16, -52.26 76.45, -12.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -137.29, 134.45 APE9-dihe-na -62.73, -15.05 APE8-dihe-out -64.93, -17.06 APE8-rot-out 49.49 APE67-dihe-in -61.37, -23.14 -117.2, -17.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9695 None None None XRAY 2.0 0.207 0.243 A 372.0 342.0 6 25 19 6 [[24, 308]] 1.0 3fsk Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HA8A Q16539 4 352 360.0 5JZ:361 Type1 Inactive DFGin 7.6116 16.3381 None -141.16, 163.83 56.43, 72.99 -75.34, 999.0 309.72, 73.83 999.0, 999.0 in-out in 9.8651 Saltbr-out 4.0704 HRD-in -63.56, -51.44 79.66, -26.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -132.89, 139.9 APE9-dihe-na -58.34, -25.0 APE8-dihe-out -56.24, -14.15 APE8-rot-out 54.17 APE67-dihe-in -68.66, -11.09 -127.46, -12.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1308 None None None XRAY 2.48 0.217 0.248 A 379.0 342.0 7 25 18 7 [[24, 308]] 1.0 3ha8 Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4F9WA Q16539 5 352 360.0 LM4:403 Type1 Inactive DFGin 7.7255 16.584 None -80.52, 176.23 -63.07, 104.95 -100.59, 2.82 54.46, 75.64 130.88, -79.74 in-out in 9.4539 Saltbr-out 4.5982 HRD-in -68.07, -55.53 83.11, -14.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 138.42 APE8-dihe-out -55.74, -38.36 APE8-rot-in 282.33 APE67-dihe-in -59.63, -26.4 -42.98, -44.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3918 None None None XRAY 2.0 0.173 0.216 A 383.0 336.0 12 25 13 12 [[24, 308]] 1.0 4f9w Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4FA2A Q16539 4 353 360.0 SB0:402 Type1 Inactive DFGin 8.1265 13.3665 None -98.53, 119.73 -70.7, -31.65 -138.38, 143.95 311.3, 93.7 107.84, 75.14 in-in in 9.0918 Saltbr-in 2.481 HRD-in -68.79, -53.09 81.55, -18.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -80.2 APE9-dihe-na -62.71, 131.19 APE8-dihe-out -61.7, -39.74 APE8-rot-in 283.35 APE67-dihe-in -60.81, -26.39 -57.15, -28.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1525 APE9-dist-out 11.2807 None None None XRAY 2.0 0.174 0.215 A 383.0 339.0 11 25 14 11 [[24, 308]] 1.0 4fa2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4ZTHA Q16539 4 353 360.0 VVT:401 Type1 Inactive DFGin 8.3008 13.855 None -89.83, 123.18 -77.72, -39.39 -125.61, 120.62 298.26, 98.01 -83.63, -144.08 in-in in 9.2036 Saltbr-in 2.9023 HRD-in -71.36, -49.73 75.36, -10.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -91.32 APE9-dihe-na -69.69, 130.87 APE8-dihe-out -61.18, -39.46 APE8-rot-in 289.92 APE67-dihe-in -57.67, -28.49 -59.49, -25.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5913 APE9-dist-out 11.6954 None None None XRAY 2.15 0.184 0.24 A 383.0 339.0 11 25 14 11 [[24, 308]] 1.0 4zth Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9O4LA Q16539 5 353 360.0 A1B8B:402 Type1 Inactive DFGin 5.0897 15.55 None -133.08, 171.57 61.65, 21.84 -73.72, 999.0 76.92, 114.61 999.0, 999.0 in-in in 9.488 Saltbr-in 2.7441 HRD-in -65.15, -53.31 77.94, -18.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.35 APE8-rot-in 324.94 APE67-dihe-out -67.13, -12.17 -110.61, 107.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.193 0.241 A 384.0 334.0 15 25 10 15 [[24, 308]] 1.0 9o4l Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3O8PA Q16539 5 351 360.0 BMU:361 Type1 Inactive DFGin 10.8634 12.0139 None -115.52, 162.58 -99.08, -26.53 -122.71, 117.21 291.85, 138.97 -42.63, -102.67 in-out in 9.092 Saltbr-out 5.0854 HRD-in -69.17, -52.21 73.92, -4.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 3.16 APE9-dihe-na -166.83, -167.55 APE8-dihe-out -116.39, -25.53 APE8-rot-in 271.29 APE67-dihe-in -61.81, -26.71 -69.76, -21.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.1587 APE9-dist-out 10.4529 D168G None None XRAY 2.1 0.218 0.276 A 360.0 336.0 11 25 14 11 [[24, 308]] 1.0 3o8p Homo sapiens CMGC_MAPK14_HUMAN CMGC 2.7e-83 285.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OBGA Q16539 5 352 360.0 SB2:361 Type1 Inactive DFGin 8.5471 15.5472 None -95.25, 144.72 58.8, 33.65 -69.14, 75.21 999.0, 999.0 119.93, 18.42 in-in in 9.1521 Saltbr-in 2.4857 HRD-in -65.99, -57.89 82.28, -14.21 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.23 APE8-rot-in 336.97 APE67-dihe-in -54.89, -27.15 -56.97, -19.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169G None None XRAY 2.8 0.222 0.323 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3obg Homo sapiens CMGC_MAPK14_HUMAN CMGC 3e-83 285.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9D75A Q16539 5 353 360.0 A1A2L:60401 Type1 Inactive DFGin 7.2315 15.7878 None -119.44, 171.6 35.49, 86.57 -63.81, 999.0 294.63, 49.65 -63.81, 999.0 in-in in 9.0602 Saltbr-in 2.5179 HRD-in -70.24, -56.4 84.64, -17.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -1.29 APE8-rot-out 180.89 APE67-dihe-out -73.6, -14.85 -63.9, 126.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.13 0.208 0.236 A 346.0 335.0 11 25 14 11 [[24, 308]] 1.0 9d75 Homo sapiens CMGC_MAPK14_HUMAN CMGC 1e-79 273.9 1.0 301.0 301.0 167 168 169 173 175 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9D7NA Q16539 5 353 360.0 A1A2O:60401 Type1 Inactive DFGin 6.7111 15.4176 None -125.4, 169.42 35.27, 85.02 -62.1, 999.0 300.08, 66.43 -62.1, 999.0 in-in in 9.1287 Saltbr-in 2.51 HRD-in -66.23, -52.52 80.02, -15.24 in-out-none SNCion out-none ActLoopNT-out 6.9136 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.33, -14.88 999.0, 144.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.973 0.214 0.257 A 346.0 337.0 9 25 16 9 [[24, 308]] 1.0 9d7n Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.3e-79 273.6 1.0 301.0 301.0 167 168 169 173 175 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EWQA Q16539 5 353 360.0 MWL:402,MWL:403 Type1,Allosteric Inactive DFGin 5.0183 13.3955 None -118.78, 173.31 61.29, 10.97 -62.77, 999.0 41.58, 86.71 999.0, 999.0 in-in in 9.2208 Saltbr-in 2.7732 HRD-in -66.73, -55.27 77.04, -7.68 in-out-out SNCioo out-out ActLoopNT-out 7.2789 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -109.0, 120.47 APE9-dihe-na -53.91, -56.01 APE8-dihe-in -144.08, 143.87 APE8-rot-out 173.18 APE67-dihe-out -56.97, -22.68 -121.19, 104.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2577 None TPO180 TPO180 XRAY 2.1 0.182 0.229 A 383.0 347.0 2 25 23 2 [[24, 308]] 1.0 4ewq Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4R3CA Q16539 4 352 360.0 3GF:402,3GF:403 Type1,Allosteric Inactive DFGin 4.9243 13.1341 None -118.67, 171.2 49.4, 42.48 -86.86, 999.0 38.51, 75.43 999.0, 999.0 in-out in 9.5432 Saltbr-out 3.9084 HRD-in -66.01, -56.32 81.1, -14.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 103.85 APE9-dihe-na -65.1, 130.86 APE8-dihe-out -51.86, -39.46 APE8-rot-in 289.55 APE67-dihe-in -62.53, -25.36 -48.44, -37.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2638 None None CME162 XRAY 2.06 0.178 0.217 A 383.0 336.0 13 25 12 13 [[24, 308]] 1.0 4r3c Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9NYTA Q16539 5 353 360.0 A1B7S:402,F50:404 Type1,Allosteric Inactive DFGin 4.2601 13.0797 None -116.13, 155.51 78.56, -1.77 -37.34, 999.0 47.87, 84.48 999.0, 999.0 in-out in 9.5555 Saltbr-out 4.0805 HRD-in -71.88, -52.7 83.59, -21.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.66 APE8-dihe-out -70.34, -25.73 APE8-rot-out 87.71 APE67-dihe-in -59.45, -18.84 -59.85, -29.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5386 None None None XRAY 2.16 0.195 0.24 A 384.0 335.0 14 25 11 14 [[24, 308]] 1.0 9nyt Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP2A Q16539 4 355 360.0 P36:401,I46:402,I46:403 Type1,Allosteric,Allosteric Inactive DFGin 10.3229 12.0791 None -88.89, 117.93 0.95, -90.69 -132.19, 144.91 307.84, 89.53 -100.53, 179.64 in-in in 8.9859 Saltbr-in 3.0157 HRD-in -62.69, -56.28 83.82, -16.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -83.28 APE9-dihe-na -69.46, 121.84 APE8-dihe-out -57.79, -33.94 APE8-rot-in 290.47 APE67-dihe-in -56.52, -29.08 -65.16, -23.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8086 APE9-dist-out 11.9697 None None None XRAY 2.15 0.208 0.252 A 360.0 341.0 11 25 14 11 [[24, 308]] 1.0 3hp2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP5A Q16539 6 352 360.0 52P:401,I46:402,I46:403 Type1,Allosteric,Allosteric Inactive DFGin 6.4998 14.3567 None -122.62, 154.65 81.43, 43.95 -64.35, -69.27 340.23, 142.83 -47.68, 999.0 in-in in 8.692 Saltbr-in 3.0371 HRD-in -62.14, -57.25 84.4, -19.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, -175.23 APE9-dihe-na -178.51, 127.74 APE8-dihe-out -56.55, -39.12 APE8-rot-none 999.0 APE67-dihe-in -64.7, -27.21 -46.07, -42.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3903 None None None XRAY 2.3 0.217 0.262 A 360.0 330.0 17 25 13 12 [[24, 308]] 1.0 3hp5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK6 MK06_HUMAN 7AQBB Q16659 21 320 721.0 No_ligand No_ligand Inactive DFGin 6.3975 15.2127 None -131.48, -173.72 49.63, 73.98 -75.43, 999.0 277.2, 75.11 999.0, 999.0 out-none out 12.9244 Saltbr-none 999.0 HRD-in -76.36, -53.27 81.32, -12.25 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.52, -6.95 APE9-dihe-na -95.53, 119.94 APE8-dihe-in -80.87, 140.54 APE8-rot-out 180.68 APE67-dihe-in -60.55, -29.29 -99.38, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8091 None None None XRAY 2.25 0.224 0.258 B 320.0 274.0 27 31 17 14 [[20, 316]] 1.0 7aqb Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
CMGC MAPK7 MK07_HUMAN 4IC8A Q13164 40 390 816.0 No_ligand No_ligand Inactive DFGin 5.4362 14.9236 None -92.06, 155.45 51.19, -153.45 -171.08, -173.86 273.57, 105.49 -73.94, 141.79 in-out in 9.7832 Saltbr-out 3.9015 HRD-in -66.31, -37.46 67.28, -17.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na 64.3, -2.13 APE9-dihe-na -71.09, -179.85 APE8-dihe-in -118.59, 110.66 APE8-rot-in 294.15 APE67-dihe-out -100.15, -5.62 -130.02, 108.17 APE12-dist-in 13.8803 APE11-dist-out 14.0558 APE10-dist-out 18.6204 APE9-dist-out 13.2249 None None None XRAY 2.8 0.263 0.29 A 442.0 325.0 24 32 17 15 [[55, 347]] 1.0 4ic8 Homo sapiens CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4IC8B Q13164 40 390 816.0 No_ligand No_ligand Inactive DFGin 6.3969 15.7622 None -93.15, 161.89 52.34, -151.75 -177.28, -172.69 263.71, 153.81 -56.07, 155.03 in-in in 9.7608 Saltbr-in 3.5023 HRD-in -80.21, -37.81 76.39, -22.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 67.32, -2.67 APE9-dihe-na -66.25, 157.12 APE8-dihe-in -110.21, 121.63 APE8-rot-in 263.54 APE67-dihe-out -97.54, -5.11 -133.15, 111.81 APE12-dist-out 14.5327 APE11-dist-out 14.7248 APE10-dist-out 19.5299 APE9-dist-out 13.6935 None None None XRAY 2.8 0.263 0.29 B 442.0 336.0 15 32 17 15 [[55, 347]] 1.0 4ic8 Homo sapiens CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 9LTAB Q13164 50 393 816.0 A1EKR:401 Type1 Inactive DFGin 6.7132 16.0319 None -133.43, -159.55 65.18, -109.2 88.58, 2.31 289.32, 97.82 -50.15, -33.97 in-out in 9.903 Saltbr-out 4.1905 HRD-in -74.24, -46.7 76.49, -19.02 out-in-out SNCoio in-out ActLoopNT-in 3.0531 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -98.86, 114.14 APE9-dihe-na 64.16, 0.87 APE8-dihe-out -99.06, 1.52 APE8-rot-out 36.89 APE67-dihe-in -62.91, -30.4 -78.64, -10.21 APE12-dist-in 11.2468 APE11-dist-in 10.5167 APE10-dist-out 13.6196 APE9-dist-out 11.7225 None None None XRAY 2.33 0.252 0.292 B 346.0 342.0 2 32 32 0 [[55, 347]] 1.0 9lta Homo sapiens CMGC_MAPK7_HUMAN CMGC 4.3e-81 278.5 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK8 MK08_HUMAN 4UX9B P45983 8 362 427.0 ANP:1000 ATPlike Inactive DFGin 6.8269 14.0009 None -95.23, -79.97 -82.17, 124.02 -113.22, 13.68 297.81, 107.19 -60.29, -32.64 in-in in 8.6029 Saltbr-in 2.9418 HRD-in -59.44, -53.0 79.08, -24.85 in-in-in SNCiii in-in ActLoopNT-in 2.5822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.47, -40.48 APE9-dihe-na -78.17, 138.93 APE8-dihe-in -64.59, 122.35 APE8-rot-in 308.57 APE67-dihe-in -67.83, -19.56 -32.59, -57.13 APE12-dist-in 12.3608 APE11-dist-in 12.1486 APE10-dist-in 6.5271 APE9-dist-in 4.6911 None None None XRAY 2.34 0.202 0.24 B 364.0 327.0 14 27 21 6 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2G01B P45983 9 364 427.0 73Q:61001 Type1 Inactive DFGin 5.7329 14.7118 None -124.05, -159.93 70.3, -99.04 78.28, -8.58 269.85, 26.32 -60.64, -29.84 in-in in 9.3096 Saltbr-in 3.522 HRD-in -75.33, -51.61 81.6, -31.16 in-in-out SNCiio in-out ActLoopNT-in 3.0497 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -55.32, -77.05 APE9-dihe-na -50.72, 131.97 APE8-dihe-in -62.41, 127.97 APE8-rot-out 179.45 APE67-dihe-in -34.47, -20.37 -26.15, -85.34 APE12-dist-in 12.6428 APE11-dist-in 12.8438 APE10-dist-in 7.3262 APE9-dist-in 4.7568 T183E,Y185E None None XRAY 3.5 0.296 0.354 B 370.0 356.0 0 27 27 0 [[26, 321]] 1.0 2g01 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2GMXB P45983 7 364 427.0 877:61001 Type1 Inactive DFGin 5.6113 13.9429 None -106.95, -175.57 54.48, -113.25 110.31, -6.6 279.44, 165.75 -41.3, -39.48 in-out in 8.4562 Saltbr-out 4.4993 HRD-in -77.53, -48.43 77.05, -21.57 out-in-in SNCoii in-in ActLoopNT-in 2.8017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.75, -77.84 APE9-dihe-na -45.43, 98.08 APE8-dihe-in -37.04, 123.81 APE8-rot-in 354.32 APE67-dihe-in -25.17, -38.2 -26.5, -90.08 APE12-dist-in 11.7738 APE11-dist-in 12.5874 APE10-dist-in 7.2474 APE9-dist-in 4.4727 T183E,Y185E None None XRAY 3.5 0.278 0.351 B 370.0 358.0 0 27 27 0 [[26, 321]] 1.0 2gmx Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK9 MK09_HUMAN 7CMLA P45984 1 364 424.0 No_ligand No_ligand Inactive DFGin 4.7496 14.8247 None -87.28, -45.52 -108.01, 154.81 -155.1, 45.31 47.34, 102.79 85.29, 999.0 in-in in 9.0823 Saltbr-in 2.8348 HRD-in -65.79, -57.36 78.71, -13.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 167.69 APE8-rot-out 53.66 APE67-dihe-in -63.3, -29.48 -74.93, -11.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A None None XRAY 2.15 0.286 0.327 A 381.0 334.0 24 27 11 16 [[26, 321]] 1.0 7cml Homo sapiens CMGC_MAPK9_HUMAN CMGC 9.6e-84 287.1 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 7CMLB P45984 1 364 424.0 No_ligand No_ligand Inactive DFGin 4.7435 14.823 None -88.87, -45.55 -106.26, 153.92 -155.16, 45.33 47.81, 103.41 83.93, 999.0 in-in in 9.0777 Saltbr-in 2.8931 HRD-in -64.4, -56.23 76.1, -8.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 170.08 APE8-rot-out 54.21 APE67-dihe-in -61.48, -28.24 -72.46, -14.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A None None XRAY 2.15 0.286 0.327 B 381.0 335.0 23 27 11 16 [[26, 321]] 1.0 7cml Homo sapiens CMGC_MAPK9_HUMAN CMGC 9.6e-84 287.1 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
NEK NEK2 NEK2_HUMAN 2XKDA P51955 3 271 445.0 T3M:61280 Type1 Inactive DFGin 7.7821 14.7211 None -118.6, -157.91 42.92, 77.2 -104.57, 999.0 308.02, 95.14 999.0, 999.0 out-out out 12.5186 Saltbr-out 9.1741 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 73.57, -54.62 APE9-dihe-na -57.09, 148.53 APE8-dihe-in -95.98, 122.75 APE8-rot-in 312.67 APE67-dihe-out -54.02, -37.1 -77.53, 67.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.183 0.217 A 279.0 243.0 26 28 14 14 [[8, 271]] 1.0 2xkd Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XKEA P51955 3 271 445.0 WI2:61280 Type1 Inactive DFGin 7.7802 14.674 None -126.61, -154.27 59.66, -98.99 82.09, 999.0 300.47, 105.7 999.0, 999.0 out-out out 12.1546 Saltbr-out 8.5597 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 108.7 APE8-rot-in 350.6 APE67-dihe-out -48.98, -38.02 -83.19, 66.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.203 0.178 0.226 A 279.0 235.0 34 28 10 18 [[8, 271]] 1.0 2xke Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XKFA P51955 3 271 445.0 BX1:61280 Type1 Inactive DFGin 8.0242 14.7934 None -136.65, 176.84 62.75, 83.47 -107.53, 999.0 295.67, 92.44 999.0, 999.0 out-out out 12.0968 Saltbr-out 8.6686 HRD-none 999.0, 999.0 999.0, -165.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -96.76, -179.12 APE9-dihe-na 106.62, 145.4 APE8-dihe-in -83.33, 139.63 APE8-rot-out 49.39 APE67-dihe-out -45.16, -35.54 -81.58, 70.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.8549 None None None XRAY 2.35 0.174 0.222 A 279.0 242.0 27 28 13 15 [[8, 271]] 1.0 2xkf Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 5M51A P51955 3 271 445.0 NU6:60301 Type1 Inactive DFGin 6.9172 15.0332 None -135.97, -170.98 47.05, 66.56 -67.3, 999.0 280.24, 65.86 999.0, 999.0 out-none out 13.3278 Saltbr-none 999.0 HRD-in -68.55, -48.07 77.08, -5.68 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, -15.98 APE9-dihe-na -61.81, 166.03 APE8-dihe-in -100.33, 135.8 APE8-rot-out 177.14 APE67-dihe-out -48.68, -33.32 -89.41, 73.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.1497 None None None XRAY 1.899 0.224 0.257 A 279.0 253.0 16 28 12 16 [[8, 271]] 1.0 5m51 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 5M57A P51955 3 271 445.0 4SP:60301 Type1 Inactive DFGin 6.8566 14.9053 None -135.46, -174.37 50.79, 73.32 -79.95, 999.0 289.86, 69.03 999.0, 999.0 out-none out 13.1668 Saltbr-none 999.0 HRD-in -67.32, -45.79 72.98, 0.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, -18.35 APE9-dihe-na -78.84, 166.93 APE8-dihe-in -97.45, 140.37 APE8-rot-out 196.13 APE67-dihe-out -44.71, -40.0 -94.19, 69.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.2658 None None None XRAY 2.3 0.221 0.274 A 279.0 253.0 16 28 12 16 [[8, 271]] 1.0 5m57 Homo sapiens NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 9NFQC Q8TDX7 20 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.3069 11.9804 None -150.16, -164.53 74.32, -54.68 63.51, 118.45 304.42, 170.07 -50.32, 115.41 out-out out 14.52 Saltbr-out 10.4482 HRD-in -75.46, -45.69 71.31, -4.13 out-out-out SNCooo out-out ActLoopNT-out 9.1773 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.74, 126.83 APE9-dihe-na 80.61, 29.64 APE8-dihe-in -127.17, 154.0 APE8-rot-out 66.52 APE67-dihe-out -56.05, -43.39 -68.04, 167.92 APE12-dist-out 15.571 APE11-dist-out 14.5314 APE10-dist-out 11.8253 APE9-dist-out 8.4872 None None None XRAY 3.25 0.214 0.261 C 304.0 281.0 0 28 28 0 [[34, 294]] 1.0 9nfq Homo sapiens NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQNA Q8TDX7 21 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.3657 14.509 None -71.0, 173.16 -64.84, 135.91 -62.15, 999.0 305.22, 52.49 999.0, 999.0 out-out out 14.0336 Saltbr-out 12.9475 HRD-in -74.75, -50.15 86.13, -19.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.46 APE8-rot-none 999.0 APE67-dihe-out -63.25, -48.51 -54.4, 143.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.192 0.221 A 310.0 259.0 21 28 10 18 [[34, 294]] 1.0 2wqn Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4K Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7265 12.7016 None -76.42, 178.47 -68.48, 131.61 -71.46, 136.2 73.57, 100.38 -72.87, 999.0 out-none out 15.6456 Saltbr-none 999.0 HRD-out -85.33, 115.72 -60.76, -44.72 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.68 APE8-rot-in 320.17 APE67-dihe-out -62.46, -41.14 -76.28, 170.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 K 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4L Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7281 12.7014 None -76.4, 178.58 -68.63, 131.64 -71.57, 136.19 73.61, 100.3 -72.85, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.34, 115.69 -60.77, -44.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.69 APE8-rot-in 320.25 APE67-dihe-out -62.33, -41.29 -76.38, 170.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 L 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4M Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7275 12.7029 None -76.4, 178.51 -68.6, 131.68 -71.51, 136.18 73.59, 100.26 -72.74, 999.0 out-none out 15.6446 Saltbr-none 999.0 HRD-out -85.42, 115.71 -60.74, -44.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.73 APE8-rot-in 320.25 APE67-dihe-out -62.39, -41.25 -76.39, 170.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 M 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4N Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7275 12.7015 None -76.43, 178.48 -68.52, 131.6 -71.44, 136.14 73.59, 100.37 -72.79, 999.0 out-none out 15.6461 Saltbr-none 999.0 HRD-out -85.34, 115.77 -60.86, -44.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.75 APE8-rot-in 320.35 APE67-dihe-out -62.31, -41.37 -76.45, 170.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 N 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4O Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7269 12.7018 None -76.34, 178.47 -68.49, 131.55 -71.34, 136.17 73.67, 100.39 -72.81, 999.0 out-none out 15.6437 Saltbr-none 999.0 HRD-out -85.31, 115.68 -60.76, -44.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.77 APE8-rot-in 320.21 APE67-dihe-out -62.36, -41.36 -76.32, 170.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 O 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4P Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7286 12.7018 None -76.31, 178.45 -68.55, 131.56 -71.36, 136.2 73.73, 100.23 -72.8, 999.0 out-none out 15.6453 Saltbr-none 999.0 HRD-out -85.31, 115.58 -60.59, -44.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.71 APE8-rot-in 320.25 APE67-dihe-out -62.34, -41.31 -76.37, 170.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 P 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4Q Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7278 12.7013 None -76.49, 178.43 -68.49, 131.55 -71.33, 136.21 73.64, 100.4 -72.85, 999.0 out-none out 15.6442 Saltbr-none 999.0 HRD-out -85.44, 115.71 -60.71, -44.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.79 APE8-rot-in 320.09 APE67-dihe-out -62.41, -41.17 -76.39, 170.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 Q 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4R Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7276 12.7013 None -76.4, 178.44 -68.5, 131.69 -71.51, 136.22 73.62, 100.38 -72.88, 999.0 out-none out 15.6433 Saltbr-none 999.0 HRD-out -85.44, 115.7 -60.7, -44.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.78 APE8-rot-in 320.16 APE67-dihe-out -62.38, -41.22 -76.37, 170.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 R 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4S Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7288 12.7035 None -76.31, 178.32 -68.42, 131.55 -71.49, 136.23 73.63, 100.27 -72.77, 999.0 out-none out 15.6452 Saltbr-none 999.0 HRD-out -85.28, 115.69 -60.57, -45.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.74 APE8-rot-in 320.25 APE67-dihe-out -62.31, -41.25 -76.38, 170.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 S 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8EJ4T Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.7275 12.7017 None -76.48, 178.46 -68.52, 131.53 -71.34, 136.16 73.66, 100.37 -72.83, 999.0 out-none out 15.6448 Saltbr-none 999.0 HRD-out -85.37, 115.71 -60.75, -44.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.75 APE8-rot-in 320.16 APE67-dihe-out -62.36, -41.21 -76.33, 170.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 T 278.0 261.0 17 28 11 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQMA Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 7.3462 13.7783 None -83.18, 179.58 -74.59, 155.64 -97.08, 999.0 302.48, 61.21 999.0, 999.0 out-out out 13.9573 Saltbr-out 15.2417 HRD-in -76.69, -51.78 83.33, -13.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 71.1 APE8-rot-none 999.0 APE67-dihe-out -59.91, -51.02 -52.53, 142.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.175 0.215 A 310.0 258.0 23 28 10 18 [[34, 294]] 1.0 2wqm Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S76B Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 10.751 13.109 None -166.45, -175.9 66.54, -60.08 52.94, 60.47 203.88, 147.31 -68.33, 173.75 out-none out 14.9478 Saltbr-none 999.0 HRD-in -70.18, -57.7 76.2, 16.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnoo APE10-dihe-na 999.0, 48.62 APE9-dihe-na -59.14, -24.85 APE8-dihe-in -73.32, 170.94 APE8-rot-none 999.0 APE67-dihe-out -57.66, -44.72 -55.45, 165.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.6367 APE9-dist-out 12.9921 None None None XRAY 3.38 0.263 0.286 B 310.0 267.0 14 28 14 14 [[34, 294]] 1.0 6s76 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S76C Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 8.5831 12.7693 None -80.45, -160.94 -77.29, 134.54 -77.74, 135.51 80.77, 94.75 -93.77, 999.0 out-none out 15.9432 Saltbr-none 999.0 HRD-out -62.26, 96.66 -62.75, -12.92 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.78 APE8-rot-out 166.56 APE67-dihe-out -62.39, -38.88 -77.41, 171.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.38 0.263 0.286 C 310.0 264.0 17 28 11 17 [[34, 294]] 1.0 6s76 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73A Q8TDX7 21 300 302.0 F9N:401 Type1 Inactive DFGin 5.0528 16.3633 None -130.23, -159.39 -58.38, 166.65 -79.47, 179.09 272.7, 63.92 -73.82, 153.18 out-none out 12.5186 Saltbr-none 999.0 HRD-in -67.13, -43.16 71.04, 8.92 none-out-out SNCnoo out-out ActLoopNT-out 13.5886 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -68.95, 142.63 APE9-dihe-na -130.01, 150.44 APE8-dihe-in -121.46, 109.43 APE8-rot-in 306.53 APE67-dihe-out -37.47, -40.83 -62.79, 124.97 APE12-dist-none 999.0 APE11-dist-out 15.4448 APE10-dist-out 16.3422 APE9-dist-out 13.3404 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 A 310.0 269.0 11 28 17 11 [[34, 294]] 1.0 6s73 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73B Q8TDX7 20 300 302.0 F9N:401 Type1 Inactive DFGin 4.0811 13.9355 None -178.99, -162.49 51.26, 73.22 -85.88, 62.38 41.39, 63.66 -85.37, 89.52 out-out out 12.5852 Saltbr-out 10.3655 HRD-in -66.25, -45.52 76.82, -13.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 162.68 APE9-dihe-na -69.13, -43.33 APE8-dihe-in -76.26, 166.14 APE8-rot-out 72.57 APE67-dihe-out -54.8, -43.78 -51.06, 164.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.7047 APE9-dist-out 14.4116 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 B 310.0 268.0 13 28 15 13 [[34, 294]] 1.0 6s73 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S73C Q8TDX7 26 300 302.0 F9N:401 Type1 Inactive DFGin 5.1386 15.7119 None 175.05, 74.28 -158.3, 138.44 -107.91, 105.5 333.64, 111.47 -61.5, -31.06 out-none out 13.7395 Saltbr-none 999.0 HRD-in -76.21, -36.25 71.18, -6.76 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.69 APE8-rot-in 301.01 APE67-dihe-out -51.09, -38.47 -89.97, 146.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 C 310.0 259.0 16 28 12 16 [[34, 294]] 1.0 6s73 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S75B Q8TDX7 20 300 302.0 F9N:401 Type1 Inactive DFGin 7.4128 13.763 None -73.24, -152.21 -93.79, 137.64 -65.56, 124.67 301.05, 76.91 -140.58, 68.85 out-none out 15.5675 Saltbr-none 999.0 HRD-out -97.46, 106.21 -102.94, 24.07 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 46.75 APE8-dihe-in -82.12, 132.19 APE8-rot-none 999.0 APE67-dihe-out 55.67, -108.68 -80.05, 59.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8172 None None None XRAY 3.3 0.263 0.317 B 310.0 267.0 14 28 14 14 [[34, 294]] 1.0 6s75 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S75C Q8TDX7 22 300 302.0 F9N:401 Type1 Inactive DFGin 7.9029 12.9937 None -83.1, -140.31 -120.94, 14.53 61.24, -160.83 311.61, 103.49 -179.49, 170.79 out-none out 16.2627 Saltbr-none 999.0 HRD-in -77.1, -41.1 71.89, -12.02 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 68.43 APE8-rot-in 309.88 APE67-dihe-out -56.73, -49.48 -77.1, 161.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.263 0.317 C 310.0 263.0 16 28 12 16 [[34, 294]] 1.0 6s75 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
OTHER EIF2AK2 E2AK2_HUMAN 6D3LA P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.4282 13.5478 None -156.44, 50.2 -150.13, 79.38 -93.22, 34.5 307.79, 100.69 -75.1, -22.66 in-out in 8.2504 Saltbr-out 4.2085 HRD-out -109.72, 76.87 -49.41, -33.81 out-in-none SNCoin in-none ActLoopNT-in 2.8933 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.263 0.347 A 323.0 248.0 36 27 10 17 [[175, 537]] 1.0 6d3l Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUA P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.6173 12.2243 None 179.67, 47.65 -88.7, 86.35 -91.15, -3.67 303.64, 112.16 -78.11, 27.75 in-none in 8.5398 Saltbr-none 999.0 HRD-out -82.64, 83.35 -71.69, 48.72 none-in-out SNCnio in-out ActLoopNT-in 2.9471 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.49 APE8-rot-none 999.0 APE67-dihe-out -150.85, -147.51 -45.22, 110.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 A 306.0 255.0 33 27 16 11 [[175, 537]] 1.0 3uiu Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.3e-48 170.6 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUB P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.6133 12.222 None 179.62, 47.59 -88.43, 86.11 -90.92, -3.17 303.82, 112.2 -78.41, 27.48 in-none in 8.5339 Saltbr-none 999.0 HRD-out -82.77, 83.49 -72.08, 48.76 none-in-out SNCnio in-out ActLoopNT-in 2.9495 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.65 APE8-rot-none 999.0 APE67-dihe-out -150.91, -147.37 -45.27, 110.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 B 306.0 255.0 33 27 16 11 [[175, 537]] 1.0 3uiu Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.3e-48 170.6 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK3 E2AK3_HUMAN 4X7OA Q9NZJ5 585 1081 1116.0 3Z6:1101 Type1 Inactive DFGin 6.3414 13.6426 None -94.22, -155.12 -53.25, 136.69 -155.12, 166.24 66.84, 102.95 73.29, 999.0 out-out out 12.5237 Saltbr-out 8.5689 HRD-in -83.31, -58.9 75.59, 7.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.73 APE8-rot-out 177.5 APE67-dihe-in -54.31, -34.32 -114.42, 10.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.65 0.2 0.226 A 317.0 246.0 46 40 11 29 [[593, 1077]] 1.0 4x7o Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 7MF0AAA Q9NZJ5 586 1080 1116.0 Z6P:61101 Type1 Inactive DFGin 6.0948 13.7835 None -77.51, -156.87 -60.47, 147.45 -172.68, 155.23 76.53, 99.05 77.56, 168.51 out-out out 12.7278 Saltbr-out 8.739 HRD-in -96.15, -47.28 50.09, 33.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.24 APE8-rot-out 176.88 APE67-dihe-in -78.52, -21.92 -131.22, 23.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.809 0.234 0.273 AAA 317.0 259.0 31 40 13 27 [[593, 1077]] 1.0 7mf0 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQ9AAA Q9NZJ5 585 1080 1116.0 WPB:1101 Type1 Inactive DFGin 6.336 13.3424 None -89.55, -152.51 -63.21, 140.56 -148.5, 177.54 60.71, 99.01 64.9, 170.78 out-out out 12.6992 Saltbr-out 8.372 HRD-in -76.32, -70.44 74.66, 17.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 156.68 APE8-rot-out 169.43 APE67-dihe-in -67.45, -23.48 -135.96, 8.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.86 0.241 0.277 AAA 317.0 253.0 38 40 13 27 [[593, 1077]] 1.0 8eq9 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQDAAA Q9NZJ5 585 1080 1116.0 WPX:1101 Type1 Inactive DFGin 6.5107 13.3932 None -76.6, -162.05 -50.39, 140.83 -163.18, 172.47 74.08, 87.8 62.7, 177.79 out-out out 12.9537 Saltbr-out 8.0923 HRD-in -67.23, -62.02 65.5, 23.69 out-out-out SNCooo out-out ActLoopNT-out 11.8159 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.26 APE8-rot-out 186.47 APE67-dihe-in -80.59, -35.16 -113.72, 25.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.92 0.248 0.28 AAA 317.0 256.0 35 40 15 25 [[593, 1077]] 1.0 8eqd Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G31A Q9NZJ5 588 1080 1116.0 0WH:61102 Type1.5_Back Inactive DFGin 6.2319 13.8316 None -84.54, -159.02 -56.0, 133.56 -155.02, 170.5 66.17, 105.5 78.35, 175.83 out-out out 13.0614 Saltbr-out 9.6996 HRD-in -87.72, -55.13 80.73, -18.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.1 APE8-dihe-in -65.54, 146.89 APE8-rot-out 180.58 APE67-dihe-in -54.55, -32.6 -106.33, 6.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3041 None None None XRAY 2.28 0.205 0.242 A 299.0 247.0 38 40 14 26 [[593, 1077]] 1.0 4g31 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G34A Q9NZJ5 588 1079 1116.0 924:61101 Type1.5_Back Inactive DFGin 6.097 13.6797 None -82.87, -161.08 -56.81, 138.38 -162.6, 172.39 72.3, 101.28 108.73, -50.4 out-out out 12.6916 Saltbr-out 9.7672 HRD-in -88.56, -52.58 79.71, -18.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.81 APE8-dihe-in -70.71, 157.12 APE8-rot-out 46.57 APE67-dihe-in -60.9, -30.41 -107.3, 13.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2436 None None None XRAY 2.7 0.21 0.258 A 299.0 247.0 37 40 13 27 [[593, 1077]] 1.0 4g34 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4M7IA Q9NZJ5 588 1080 1116.0 27D:61101 Type1.5_Back Inactive DFGin 6.0292 13.826 None -84.66, -156.85 -61.94, 137.1 -158.49, 171.52 68.59, 102.9 119.66, -36.59 out-out out 12.7894 Saltbr-out 10.7583 HRD-in -87.5, -55.06 77.0, -17.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.52 APE8-dihe-in -64.41, 144.81 APE8-rot-out 183.67 APE67-dihe-in -62.47, -30.87 -109.76, 13.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1349 None None None XRAY 2.34 0.209 0.282 A 299.0 246.0 39 40 14 26 [[593, 1077]] 1.0 4m7i Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQEAAA Q9NZJ5 585 1080 1116.0 WQ2:1101 Type1.5_Back Inactive DFGin 6.2009 13.869 None -81.55, -152.92 -57.14, 146.2 -169.63, 166.16 75.82, 96.97 68.96, 171.99 out-out out 13.2313 Saltbr-out 9.1534 HRD-in -75.93, -57.84 73.17, 14.99 out-out-out SNCooo out-out ActLoopNT-out 12.8182 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.43 APE8-rot-out 173.87 APE67-dihe-in -71.31, -21.9 -114.54, 9.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.559 0.227 0.287 AAA 317.0 256.0 35 40 14 26 [[593, 1077]] 1.0 8eqe Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6A Q9P2K8 584 1004 1649.0 38O:1701 Type1 Inactive DFGin 4.5453 13.8322 None -64.42, 179.79 -78.36, -177.52 -104.81, 135.74 11.85, 74.61 -87.56, 999.0 out-out out 10.4039 Saltbr-out 7.2276 HRD-in -78.55, -45.81 67.95, -11.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -139.37, 156.89 APE9-dihe-na 68.88, -136.49 APE8-dihe-out -63.0, -22.3 APE8-rot-out 54.98 APE67-dihe-in -64.33, -22.31 -64.88, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3092 D848N None None XRAY 2.8 0.213 0.258 A 320.0 269.0 26 46 26 20 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6B Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.7434 14.4365 None -62.22, 177.25 -71.17, -177.31 -113.77, 112.84 16.57, 83.07 -117.04, 75.83 out-out out 10.6295 Saltbr-out 6.7733 HRD-in -73.84, -58.14 68.49, 11.03 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.51, 135.89 APE9-dihe-na 67.14, -114.96 APE8-dihe-out -68.69, -35.73 APE8-rot-out 40.19 APE67-dihe-in -61.7, -18.1 -60.4, -26.4 APE12-dist-out 22.8084 APE11-dist-out 18.7912 APE10-dist-out 18.981 APE9-dist-out 12.6461 D848N None None XRAY 2.8 0.213 0.258 B 320.0 275.0 22 46 28 18 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6C Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 5.1533 15.3312 None -67.88, 178.26 -74.84, 168.69 -62.36, -56.97 309.72, 121.46 57.54, 31.05 out-out out 10.4307 Saltbr-out 6.7866 HRD-in -71.08, -48.65 67.11, -5.82 out-out-out SNCooo out-out ActLoopNT-out 7.7299 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.35 APE8-dihe-out -115.25, -20.91 APE8-rot-out 51.72 APE67-dihe-in -84.71, -19.81 -111.62, 33.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7921 D848N None None XRAY 2.8 0.213 0.258 C 320.0 267.0 30 46 17 29 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6D Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.7934 14.7823 None -71.0, 172.41 -73.73, 163.04 -66.19, -82.98 327.33, 91.13 74.54, 67.6 out-out out 11.1023 Saltbr-out 6.778 HRD-in -68.97, -46.58 79.03, -46.68 out-out-none SNCoon out-none ActLoopNT-out 6.5052 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.25, -17.58 999.0, -55.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.8 0.213 0.258 D 320.0 260.0 37 46 17 29 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER ERN1 ERN1_HUMAN 4Z7GA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 4.9957 14.5333 None -140.81, 175.34 43.48, 101.03 -87.72, 999.0 308.92, 94.22 999.0, 999.0 in-in in 8.9466 Saltbr-in 2.8404 HRD-in -60.57, -47.56 72.24, -10.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, -18.99 APE9-dihe-na -167.3, -173.38 APE8-dihe-in -130.49, 124.62 APE8-rot-out 52.96 APE67-dihe-inflip 106.42, -11.92 -35.23, 118.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8338 None None None XRAY 2.6 0.204 0.226 A 416.0 366.0 26 31 12 19 [[571, 832]] 1.0 4z7g Homo sapiens OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7GB O75460 562 962 977.0 No_ligand No_ligand Inactive DFGin 4.9099 14.386 None -141.89, 174.99 45.35, 92.04 -84.88, 999.0 313.4, 110.77 999.0, 999.0 in-in in 8.916 Saltbr-in 2.8322 HRD-in -60.96, -47.53 72.73, -11.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -63.92, -20.1 APE9-dihe-na -168.1, 175.6 APE8-dihe-in -122.17, 125.73 APE8-rot-out 53.21 APE67-dihe-inflip 110.25, -18.1 -36.38, 118.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8352 None None None XRAY 2.6 0.204 0.226 B 416.0 377.0 24 31 13 18 [[571, 832]] 1.0 4z7g Homo sapiens OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7HA O75460 562 963 977.0 4L5:1001 Type1 Inactive DFGin 5.3928 14.9773 None -138.87, -45.43 -76.98, 88.77 -83.95, 3.75 273.49, 77.38 -61.03, -41.59 in-in in 8.8506 Saltbr-in 2.8087 HRD-in -73.17, -46.77 63.73, 3.56 in-in-out SNCiio in-out ActLoopNT-in 2.9283 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -6.85 APE9-dihe-na 151.6, -155.97 APE8-dihe-in -123.5, 123.79 APE8-rot-out 45.5 APE67-dihe-inflip 106.26, -20.23 -56.36, 141.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6127 APE9-dist-in 4.6464 None None None XRAY 2.9 0.202 0.225 A 416.0 385.0 10 31 26 5 [[571, 832]] 1.0 4z7h Homo sapiens OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER HASPIN HASP_HUMAN 9B2TK Q8TF76 470 798 798.0 No_ligand No_ligand Inactive DFGin 10.4725 16.9979 None -74.01, 167.84 -68.22, 151.89 -112.4, 131.65 323.3, 85.18 -72.17, -31.47 out-out out 10.3713 Saltbr-out 8.7387 HRD-naN -90.05, -46.55 60.89, 17.99 out-in-na SNCoia in-na ActLoopNT-in 2.5087 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -99.75, 7.12 APE9-dihe-na -76.13, 178.32 APE8-dihe-na -157.85, 172.7 APE8-rot-na 78.9 APE67-dihe-na -161.94, 175.92 118.79, -26.14 APE12-dist-na 11.1904 APE11-dist-na 13.5351 APE10-dist-na 18.0641 APE9-dist-na 14.0274 None None None EM 2.99 999.0 999.0 K 357.0 329.0 0 35 35 0 [[484, 797]] 1.0 9b2t Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1.0 314.0 314.0 686 687 688 690 692 511 535 539 646 648 647 649.0 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER IKBKB IKKB_HUMAN 4E3CA O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.9293 12.5145 None -102.89, -152.86 -13.03, 129.81 -123.22, 17.82 259.81, 46.81 -50.25, -6.57 in-in in 8.4978 Saltbr-in 2.7367 HRD-in -75.26, -33.92 66.88, -70.59 in-in-out SNCiio in-out ActLoopNT-in 2.667 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na 54.47, 176.72 APE9-dihe-na 61.59, 168.61 APE8-dihe-out -55.76, -20.8 APE8-rot-out 96.27 APE67-dihe-out -19.53, -58.21 71.19, -31.91 APE12-dist-in 7.8908 APE11-dist-in 11.3832 APE10-dist-out 9.7094 APE9-dist-out 11.5196 S177E,S181E None None XRAY 3.98 0.267 0.299 A 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CE O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.9501 12.2838 None -103.98, -153.14 -13.07, 129.81 -119.97, 29.25 259.42, 48.55 -39.7, -60.66 in-in in 8.4922 Saltbr-in 2.789 HRD-in -74.27, -34.04 66.66, -69.45 in-in-out SNCiio in-out ActLoopNT-in 2.7665 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -137.36, 34.73 APE9-dihe-na -147.47, 29.61 APE8-dihe-out 50.03, 13.62 APE8-rot-out 70.79 APE67-dihe-out 72.17, -45.62 58.67, -106.57 APE12-dist-in 7.8793 APE11-dist-in 9.547 APE10-dist-out 9.1157 APE9-dist-out 10.7947 S177E,S181E None None XRAY 3.98 0.267 0.299 E 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER PINK1 PINK1_HUMAN 9EIHB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.6424 15.2899 None -150.1, 27.9 -151.22, 84.19 -78.07, 7.71 280.09, 73.93 -56.26, -25.65 in-in in 8.1541 Saltbr-in 2.8752 HRD-out -83.89, 74.38 -55.2, 147.76 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 129.6, 170.75 APE9-dihe-na -57.41, 126.81 APE8-dihe-in -63.88, 123.56 APE8-rot-na 292.08 APE67-dihe-out -68.62, -37.63 170.95, 170.71 APE12-dist-in 8.2649 APE11-dist-in 10.7013 APE10-dist-in 6.1781 APE9-dist-in 5.5107 None None None EM 3.1 999.0 999.0 B 603.0 443.0 76 34 34 0 [[149, 517]] 1.0 9eih Homo sapiens OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1.0 371.0 371.0 383 384 385 387 389 219 240 244 359 361 360 362.0 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIIB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.5376 15.2684 None -148.12, 29.18 -150.34, 82.77 -78.44, 7.18 280.06, 75.46 -55.89, -31.96 in-in in 8.1906 Saltbr-in 2.6988 HRD-out -84.11, 73.3 -54.72, 147.35 in-in-out SNCiio in-out ActLoopNT-in 2.8909 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 126.48, 169.31 APE9-dihe-na -55.3, 129.37 APE8-dihe-in -64.28, 120.54 APE8-rot-na 293.88 APE67-dihe-out -69.11, -35.23 177.3, 167.48 APE12-dist-in 8.425 APE11-dist-in 10.6482 APE10-dist-in 6.0928 APE9-dist-in 5.5648 None None None EM 2.75 999.0 999.0 B 603.0 443.0 76 34 34 0 [[149, 517]] 1.0 9eii Homo sapiens OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1.0 371.0 371.0 383 384 385 387 389 219 240 244 359 361 360 362.0 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIJB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.5773 15.6313 None -148.4, 28.85 -150.95, 82.12 -77.4, 7.45 279.57, 75.37 -55.31, -31.89 in-in in 8.3355 Saltbr-in 3.1731 HRD-out -83.93, 72.97 -54.61, 147.01 in-in-out SNCiio in-out ActLoopNT-in 2.7745 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 126.25, 168.92 APE9-dihe-na -55.5, 129.75 APE8-dihe-in -63.67, 120.0 APE8-rot-na 293.7 APE67-dihe-out -68.89, -34.96 176.76, 167.65 APE12-dist-in 8.2697 APE11-dist-in 10.7719 APE10-dist-in 6.249 APE9-dist-in 5.4487 None None None EM 3.3 999.0 999.0 B 603.0 443.0 76 34 34 0 [[149, 517]] 1.0 9eij Homo sapiens OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1.0 371.0 371.0 383 384 385 387 389 219 240 244 359 361 360 362.0 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER TBK1 TBK1_HUMAN 6BNYA Q9UHD2 1 657 729.0 E0M:801 Type1 Inactive DFGin 6.8713 14.259 None -144.13, -26.45 -127.29, 108.83 -162.84, 152.36 47.44, 84.0 75.64, 999.0 out-out out 14.7547 Saltbr-out 12.9204 HRD-in -102.85, -58.68 62.76, -53.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.55 APE8-rot-in 310.76 APE67-dihe-in -67.57, -21.0 -66.63, -30.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.341 0.233 0.287 A 660.0 609.0 34 27 11 16 [[9, 625]] 1.0 6bny Homo sapiens OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6BOEA Q9UHD2 1 657 729.0 E0S:60701 Type1 Inactive DFGin 6.9192 14.0337 None -140.29, -57.72 -92.01, 95.65 -150.11, 999.0 50.59, 85.3 999.0, 999.0 out-out out 14.2378 Saltbr-out 11.8956 HRD-in -100.51, -43.17 59.35, -67.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -167.84 APE8-dihe-in -93.97, 148.54 APE8-rot-in 317.28 APE67-dihe-in -97.0, -14.84 -58.66, -27.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.8984 None None None XRAY 3.598 0.246 0.291 A 660.0 599.0 46 27 11 16 [[9, 625]] 1.0 6boe Homo sapiens OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ0A Q9UHD2 1 657 729.0 F8M:60801 Type1 Inactive DFGin 7.0583 14.1697 None -145.32, -48.95 -97.67, 99.43 -150.2, 69.66 41.19, 106.47 -153.94, 166.29 out-out out 14.6205 Saltbr-out 12.4927 HRD-in -82.5, -25.39 61.31, -62.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -74.47 APE8-dihe-in -121.62, 145.83 APE8-rot-in 316.01 APE67-dihe-in -80.24, -16.92 -66.55, -39.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0522 None None None XRAY 3.19 0.24 0.293 A 660.0 603.0 40 27 13 14 [[9, 625]] 1.0 6cq0 Homo sapiens OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ4A Q9UHD2 1 657 729.0 F8P:60801 Type1 Inactive DFGin 6.9825 14.1972 None -148.33, -48.83 -93.41, 87.11 -146.09, 999.0 49.51, 84.45 999.0, 999.0 out-out out 14.5465 Saltbr-out 12.7304 HRD-in -82.2, -27.57 62.97, -55.42 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -72.21 APE8-dihe-in -126.99, 151.01 APE8-rot-in 318.15 APE67-dihe-in -74.77, -17.35 -67.05, -46.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7198 None None None XRAY 3.2 0.235 0.272 A 660.0 603.0 40 27 11 16 [[9, 625]] 1.0 6cq4 Homo sapiens OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ5A Q9UHD2 1 657 729.0 F8S:60801 Type1 Inactive DFGin 6.7174 14.1788 None -145.73, -48.48 -97.16, 93.96 -153.08, 999.0 53.79, 88.24 999.0, 999.0 out-out out 14.6166 Saltbr-out 12.6396 HRD-in -85.7, -26.16 62.99, -56.36 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -79.38, -18.02 999.0, -39.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.354 0.233 0.275 A 660.0 601.0 42 27 9 18 [[9, 625]] 1.0 6cq5 Homo sapiens OTHER_TBK1_HUMAN OTHER 4.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSRA Q9UHD2 2 657 729.0 KHT:60900 Type1 Inactive DFGin 6.9965 13.9548 None -156.53, -62.85 -81.29, 81.31 -143.8, 159.0 54.44, 89.38 84.08, 8.25 out-out out 14.1172 Saltbr-out 11.9582 HRD-in -102.36, -69.73 73.33, -20.77 out-out-none SNCoon out-none ActLoopNT-out 8.0414 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.29 APE8-dihe-in -74.97, 146.4 APE8-rot-in 310.67 APE67-dihe-in -80.54, -16.93 -52.28, -36.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9152 None None None XRAY 3.15 0.282 0.307 A 663.0 625.0 22 27 17 10 [[9, 625]] 1.0 6rsr Homo sapiens OTHER_TBK1_HUMAN OTHER 9.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSUA Q9UHD2 2 657 729.0 KJB:60701 Type1 Inactive DFGin 6.6376 14.1131 None -154.16, -13.81 -149.75, 80.99 -136.99, 156.49 58.38, 98.61 87.97, 3.83 out-out out 13.6649 Saltbr-out 10.5278 HRD-in -95.03, -62.14 77.79, -56.35 out-out-none SNCoon out-none ActLoopNT-out 8.3756 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.58 APE8-dihe-in -74.98, 144.67 APE8-rot-in 310.9 APE67-dihe-in -80.01, -17.92 -55.62, -36.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.4733 None None None XRAY 2.75 0.292 0.351 A 663.0 625.0 22 27 17 10 [[9, 625]] 1.0 6rsu Homo sapiens OTHER_TBK1_HUMAN OTHER 9.3e-42 150.8 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWPA Q9UHD2 2 657 729.0 BX7:60701 Type1 Inactive DFGin 7.288 13.4137 None -134.43, -56.21 -87.24, 102.18 -162.15, 172.63 51.08, 85.4 74.44, 12.62 out-out out 14.1533 Saltbr-out 13.3168 HRD-in -97.28, -65.46 67.49, -12.98 out-out-none SNCoon out-none ActLoopNT-out 7.8934 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.34 APE8-dihe-in -75.67, 146.05 APE8-rot-in 314.2 APE67-dihe-in -83.23, -17.66 -52.37, -34.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5598 S172A None None XRAY 3.065 0.283 0.335 A 659.0 625.0 22 27 17 10 [[9, 625]] 1.0 4iwp Homo sapiens OTHER_TBK1_HUMAN OTHER 7.9e-42 149.7 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWQA Q9UHD2 2 657 729.0 1FV:60701 Type1 Inactive DFGin 6.9857 13.5395 None -151.26, -54.27 -82.9, 74.22 -133.51, 165.85 51.03, 84.3 72.58, 18.91 out-out out 13.6553 Saltbr-out 10.9779 HRD-in -91.75, -57.98 64.75, -44.39 out-out-none SNCoon out-none ActLoopNT-out 7.834 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.51 APE8-dihe-in -69.41, 148.35 APE8-rot-in 313.75 APE67-dihe-in -92.47, 5.0 -54.53, -34.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1357 S172A None None XRAY 3.0 0.264 0.31 A 659.0 623.0 22 27 17 10 [[9, 625]] 1.0 4iwq Homo sapiens OTHER_TBK1_HUMAN OTHER 7.9e-42 149.7 2.0 255.0 254.0 156 157 158 160 162 38 55 59 132 134 133 135.0 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TTK TTK_HUMAN 7CHMA P33981 516 794 857.0 FZF:801 Type1 Inactive DFGin 4.4135 14.6083 None -111.88, -71.82 -63.89, 158.67 -119.5, 9.1 283.45, 179.72 82.92, -15.75 in-in in 9.5598 Saltbr-in 3.396 HRD-in -57.59, -51.23 60.31, 6.24 in-out-out SNCioo out-out ActLoopNT-out 12.2637 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -62.47 APE9-dihe-na 66.11, 172.68 APE8-dihe-out -121.28, -175.85 APE8-rot-none 999.0 APE67-dihe-in -54.56, -33.62 -132.81, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.8631 APE9-dist-out 12.904 None TPO675,TPO686 TPO675,TPO686 XRAY 2.65 0.212 0.253 A 281.0 260.0 19 30 22 8 [[525, 791]] 1.0 7chm Homo sapiens OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER WNK1 WNK1_HUMAN 4PWNA Q9H4A3 210 482 2382.0 No_ligand No_ligand Inactive DFGin 7.0567 13.279 None -116.45, -167.58 52.85, 34.92 -53.76, -53.16 298.89, 177.5 -76.46, 5.08 out-na out 14.364 Saltbr-na 999.0 HRD-in -62.97, -49.68 71.0, -9.34 na-out-none SNCaon out-none ActLoopNT-out 7.5238 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 153.02 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.84 0.231 0.274 A 274.0 245.0 28 26 13 13 [[220, 479]] 1.0 4pwn Homo sapiens OTHER_WNK1_HUMAN WNK 9e-179 598.1 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK3 WNK3_HUMAN 5O23A Q9BYP7 136 405 1800.0 No_ligand No_ligand Inactive DFGin 6.2673 15.7474 None -58.12, 150.75 -62.49, 153.69 -74.35, -24.44 301.07, 176.19 -64.82, -47.37 out-na out 15.5465 Saltbr-na 999.0 HRD-in -69.6, -49.52 69.26, 5.04 na-out-out SNCaoo out-out ActLoopNT-out 6.392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 18.0 APE9-dihe-na -73.23, 148.07 APE8-dihe-in -120.2, 82.68 APE8-rot-out 60.44 APE67-dihe-in -69.8, -9.43 -68.14, -14.79 APE12-dist-out 16.5812 APE11-dist-out 14.4317 APE10-dist-out 11.0908 APE9-dist-out 8.8043 None SEP304 SEP304 XRAY 2.25 0.207 0.239 A 285.0 270.0 0 26 26 0 [[146, 405]] 1.0 5o23 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1.0 260.0 260.0 293 294 295 297 299 176 194 198 272 274 273 275.0 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O23B Q9BYP7 132 408 1800.0 No_ligand No_ligand Inactive DFGin 5.9369 15.615 None -58.71, 149.58 -63.07, 151.65 -71.84, -20.45 305.92, 177.41 -66.4, -56.29 out-na out 16.0507 Saltbr-na 999.0 HRD-in -79.22, -48.18 69.94, -5.08 na-out-out SNCaoo out-out ActLoopNT-out 6.6174 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 20.94 APE9-dihe-na -70.16, 151.66 APE8-dihe-in -125.85, 83.91 APE8-rot-out 52.59 APE67-dihe-in -66.53, -19.04 -68.8, -9.41 APE12-dist-out 16.4092 APE11-dist-out 14.19 APE10-dist-out 10.9077 APE9-dist-out 8.4476 None SEP304 SEP304 XRAY 2.25 0.207 0.239 B 285.0 277.0 0 26 26 0 [[146, 405]] 1.0 5o23 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1.0 260.0 260.0 293 294 295 297 299 176 194 198 272 274 273 275.0 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
RGC NPR1 ANPRA_HUMAN 9BCSA P16066 503 1055 1061.0 ATP:61100 ATPlike Pseudo DFGin 7.6937 15.7366 None -74.51, -65.19 38.98, 36.73 -149.34, 137.28 313.08, 80.76 -109.19, -24.55 out-none out 17.3363 Saltbr-none 999.0 HRD-in -67.46, -13.34 80.4, -46.04 none-out-out SNCnoo out-out ActLoopNT-out 11.4528 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -59.39, -44.12 APE9-dihe-na -70.77, -47.95 APE8-dihe-out -62.03, -25.18 APE8-rot-na 74.24 APE67-dihe-in -57.49, -15.22 -74.7, -41.95 APE12-dist-out 24.0207 APE11-dist-out 19.7602 APE10-dist-out 23.1609 APE9-dist-out 13.3465 None None None EM 4.4 999.0 999.0 A 1040.0 515.0 23 28 28 0 [[539, 803]] 1.0 9bcs Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
STE MAP2K1 MP2K1_HUMAN 5YT3B Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.8963 14.534 None -102.15, -169.78 -40.15, 149.52 -75.91, 143.56 303.08, 84.8 -64.88, 94.03 out-out out 16.3586 Saltbr-out 14.8656 HRD-out -104.42, 23.77 -144.46, 111.13 out-out-out SNCooo out-out ActLoopNT-out 8.0209 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -80.58, -32.09 APE9-dihe-na -86.11, -15.83 APE8-dihe-out 58.15, 64.44 APE8-rot-in 310.76 APE67-dihe-out -122.56, 143.11 -138.66, 139.98 APE12-dist-out 19.0552 APE11-dist-out 14.0554 APE10-dist-out 18.8403 APE9-dist-out 25.9099 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 B 350.0 311.0 32 26 26 0 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7501 14.7176 None -77.53, 172.31 -71.81, 159.92 -66.82, 141.72 314.31, 87.77 -59.96, 135.61 out-out out 16.8715 Saltbr-out 15.0058 HRD-out -106.97, -11.01 -97.02, 107.72 out-out-out SNCooo out-out ActLoopNT-out 8.2442 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.82, -51.0 APE9-dihe-na -70.37, -13.35 APE8-dihe-out 47.35, 74.88 APE8-rot-out 143.99 APE67-dihe-out -134.73, 126.26 -143.64, 140.67 APE12-dist-out 19.3394 APE11-dist-out 14.3822 APE10-dist-out 19.1547 APE9-dist-out 26.1684 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 D 350.0 309.0 35 26 26 0 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8YP4A Q02750 34 384 393.0 WNT:401 Type1 Inactive DFGin 5.6499 12.5748 None -114.29, -33.59 -28.46, 108.03 -125.65, 141.38 278.55, 110.59 -62.12, 167.08 out-out out 15.0636 Saltbr-out 17.0816 HRD-out 70.59, -102.97 160.56, -67.88 out-out-out SNCooo out-out ActLoopNT-out 13.7522 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 77.83 APE9-dihe-na -121.62, 81.96 APE8-dihe-out 101.02, -24.75 APE8-rot-in 322.27 APE67-dihe-out -132.46, 136.61 -111.44, 133.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.1822 APE9-dist-out 15.9962 T286A,T292A,S298A None None XRAY 2.35 0.21 0.284 A 365.0 305.0 46 26 17 9 [[68, 361]] 1.0 8yp4 Homo sapiens STE_MAP2K1_HUMAN STE 1.9e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K6 MP2K6_HUMAN 3ENMA P52564 46 332 334.0 No_ligand No_ligand Inactive DFGin 7.2057 11.561 None -72.54, 127.3 -73.54, -5.06 -145.36, 172.63 75.39, 93.79 -81.87, 71.68 out-na out 14.7786 Saltbr-na 19.7289 HRD-in -62.52, -52.47 78.76, -8.63 na-out-none SNCaon out-none ActLoopNT-out 14.8184 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.11, 104.97 999.0, -79.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 A 316.0 278.0 9 27 18 9 [[53, 314]] 1.0 3enm Homo sapiens STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMB P52564 49 332 334.0 No_ligand No_ligand Inactive DFGin 6.4336 11.873 None -76.15, 120.81 -66.53, 1.54 -153.84, 168.39 61.21, 99.4 -71.06, 67.13 out-na out 15.0002 Saltbr-na 20.0247 HRD-in -64.57, -50.97 79.15, -4.28 na-out-none SNCaon out-none ActLoopNT-out 14.4809 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.08, 113.2 999.0, -108.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 B 316.0 271.0 13 27 19 8 [[53, 314]] 1.0 3enm Homo sapiens STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMC P52564 48 332 334.0 No_ligand No_ligand Inactive DFGin 6.8007 11.7267 None -62.87, 122.88 -68.86, -8.42 -137.51, 177.55 64.57, 100.37 -78.87, 64.07 out-na out 14.8261 Saltbr-na 19.8254 HRD-in -65.29, -57.18 66.82, -2.67 na-out-none SNCaon out-none ActLoopNT-out 14.5147 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -82.6, 107.52 999.0, -65.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 C 316.0 274.0 11 27 19 8 [[53, 314]] 1.0 3enm Homo sapiens STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 3ENMD P52564 45 332 334.0 No_ligand No_ligand Inactive DFGin 6.8746 11.4777 None -70.65, 125.17 -79.65, 11.99 -158.34, 166.38 66.09, 89.82 -77.06, 78.99 out-na out 14.5686 Saltbr-na 19.5439 HRD-in -56.29, -53.91 80.33, -16.21 na-out-none SNCaon out-none ActLoopNT-out 14.8567 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -80.61, 127.32 999.0, -136.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S207D,T211D None MSE57,MSE70,MSE79,MSE98,MSE104,MSE129,MSE132,MSE195,MSE220,MSE247,MSE309 XRAY 2.35 0.215 0.269 D 316.0 279.0 9 27 18 9 [[53, 314]] 1.0 3enm Homo sapiens STE_MAP2K6_HUMAN STE 5.1e-85 290.9 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K7 MP2K7_HUMAN 5B2MA O14733 105 400 419.0 No_ligand No_ligand Inactive DFGin 9.579 19.7731 None -127.86, 134.8 -161.61, -89.86 49.84, 999.0 177.0, 80.04 999.0, 999.0 out-na out 12.7097 Saltbr-na 12.8043 HRD-in -62.81, -53.51 71.04, 8.99 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 42.27 APE9-dihe-na -108.06, 130.67 APE8-dihe-out -63.3, -33.92 APE8-rot-na 122.97 APE67-dihe-in -63.12, -24.65 -98.4, 12.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8922 None None None XRAY 3.06 0.291 0.364 A 324.0 255.0 41 27 12 15 [[120, 380]] 1.0 5b2m Homo sapiens STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVLA O14733 102 402 419.0 1XZ:60501 Type1 Inactive DFGin 4.9356 14.7119 None -131.83, 135.57 1.69, 124.27 -119.89, 81.31 23.68, 77.2 -67.86, -14.37 in-na in 9.3478 Saltbr-na 999.0 HRD-in -75.58, -48.66 66.23, 10.91 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 161.45 APE9-dihe-na -75.62, -169.03 APE8-dihe-in -66.96, 129.78 APE8-rot-na 196.63 APE67-dihe-in -77.35, -36.68 -69.13, -18.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6445 APE9-dist-in 3.4276 None None None XRAY 2.9 0.248 0.27 A 318.0 279.0 22 27 15 12 [[120, 380]] 1.0 7ovl Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVMA O14733 102 402 419.0 21I:60501 Type1 Inactive DFGin 5.5693 14.8886 None -100.36, -115.13 -133.81, 137.4 -113.6, 82.88 349.67, 74.13 -90.73, -9.2 in-na in 9.611 Saltbr-na 4.2453 HRD-in -65.68, -55.04 65.08, 15.11 na-in-none SNCain in-none ActLoopNT-in 2.9245 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.58 APE8-dihe-in -69.89, 133.33 APE8-rot-na 191.29 APE67-dihe-in -78.39, -27.08 -69.91, -12.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.3277 None None None XRAY 2.9 0.233 0.286 A 318.0 282.0 19 27 16 11 [[120, 380]] 1.0 7ovm Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVNA O14733 102 402 419.0 2I8:60501 Type1 Inactive DFGin 4.9662 14.684 None -79.07, -108.85 -132.92, 129.36 -118.94, 86.57 14.8, 59.14 -92.78, -9.46 in-na in 8.7495 Saltbr-na 3.314 HRD-in -73.42, -49.75 66.93, 12.16 na-in-out SNCaio in-out ActLoopNT-in 2.7697 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 179.48 APE9-dihe-na -73.36, -177.84 APE8-dihe-in -62.31, 134.27 APE8-rot-na 205.08 APE67-dihe-in -72.39, -30.0 -65.21, -22.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6301 APE9-dist-in 3.5925 None None None XRAY 2.9 0.225 0.257 A 318.0 283.0 18 27 17 10 [[120, 380]] 1.0 7ovn Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 9HZ0A O14733 101 401 419.0 A1IY7:60501 Type1 Inactive DFGin 5.7468 14.9744 None -112.81, -166.53 -54.75, 142.97 -115.5, 75.64 327.47, 81.17 -69.37, -28.6 in-na in 8.8354 Saltbr-na 999.0 HRD-in -68.14, -48.97 74.35, -1.92 na-in-none SNCain in-none ActLoopNT-in 2.9492 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.19 APE8-dihe-in -74.03, 132.92 APE8-rot-na 185.24 APE67-dihe-in -65.54, -21.82 -64.33, -35.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7967 None None None XRAY 2.25 0.223 0.263 A 318.0 278.0 23 27 15 12 [[120, 380]] 1.0 9hz0 Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVKA O14733 102 401 419.0 2I5:60502 Type1.5_Back Inactive DFGin 5.7986 14.1308 None -146.4, 162.27 58.41, 85.98 -92.37, 999.0 319.32, 113.16 999.0, 999.0 in-na in 9.452 Saltbr-na 7.5825 HRD-in -63.92, -73.21 74.68, -0.77 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.217 0.244 A 318.0 256.0 44 27 2 25 [[120, 380]] 1.0 7ovk Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6IB2A O14733 102 401 419.0 862:60501 Type1.5_Front Inactive DFGin 5.2764 14.0728 None -91.61, -76.02 -109.31, 164.08 -125.38, 999.0 315.5, 111.59 999.0, 999.0 in-na in 9.9266 Saltbr-na 8.3493 HRD-out -68.06, 100.79 -82.59, 24.57 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -28.73 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.224 0.25 A 318.0 265.0 35 27 8 19 [[120, 380]] 1.0 6ib2 Homo sapiens STE_MAP2K7_HUMAN STE 3.1e-80 275.2 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP3K5 M3K5_HUMAN 5VIOC Q99683 670 940 1374.0 No_ligand No_ligand Inactive DFGin 6.3572 13.8249 None -118.22, -166.23 70.4, -83.21 71.44, -145.78 303.48, 97.0 79.63, -42.0 in-in in 8.3845 Saltbr-in 2.9481 HRD-in -67.24, -40.33 70.79, -6.68 in-in-out SNCiio in-out ActLoopNT-in 3.0199 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -146.22, 135.17 APE9-dihe-na -72.34, -160.36 APE8-dihe-in -65.61, 126.24 APE8-rot-in 312.24 APE67-dihe-in -64.54, -23.72 -53.71, -45.87 APE12-dist-in 10.9189 APE11-dist-out 5.8159 APE10-dist-out 9.8272 APE9-dist-in 3.9187 None None None XRAY 2.84 0.181 0.216 C 293.0 271.0 0 28 28 0 [[678, 938]] 1.0 5vio Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5VILC Q99683 670 940 1374.0 9E1:4000 Type1 Inactive DFGin 6.6807 13.6651 None -127.14, -166.22 81.0, -82.49 64.22, -158.94 310.26, 99.86 83.75, -48.04 in-in in 8.3873 Saltbr-in 2.7669 HRD-in -62.04, -44.3 71.5, -5.97 in-in-out SNCiio in-out ActLoopNT-in 3.0012 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.26, 132.14 APE9-dihe-na -63.89, -152.16 APE8-dihe-in -75.62, 128.61 APE8-rot-in 305.72 APE67-dihe-in -63.56, -22.05 -54.79, -48.45 APE12-dist-in 10.7945 APE11-dist-out 5.8136 APE10-dist-out 9.964 APE9-dist-in 3.8263 None None None XRAY 2.64 0.182 0.213 C 293.0 271.0 0 28 28 0 [[678, 938]] 1.0 5vil Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 7KACA Q92918 7 304 833.0 W9D:401 Type1 Inactive DFGin 8.0218 14.8051 None -141.48, 167.09 66.93, 78.4 -88.8, 999.0 297.14, 96.79 999.0, 999.0 out-out out 12.7535 Saltbr-out 11.2541 HRD-in -70.03, -49.57 71.67, 0.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -89.52, 94.35 APE9-dihe-na 120.85, -175.69 APE8-dihe-in -107.35, 147.06 APE8-rot-out 190.1 APE67-dihe-in -53.56, -32.93 -92.41, -14.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.986 L221D,F225E None None XRAY 1.85 0.217 0.232 A 340.0 283.0 15 28 13 15 [[17, 274]] 1.0 7kac Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-91 310.8 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8DA Q92918 7 293 833.0 A1ITC:301 Type1 Inactive DFGin 4.6231 14.038 None -56.45, -37.26 -153.97, -176.48 -89.45, 20.13 56.87, 83.02 106.24, -162.07 out-out out 13.3927 Saltbr-out 11.4109 HRD-in -65.3, -52.29 59.62, 17.42 out-out-out SNCooo out-out ActLoopNT-out 6.9406 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -60.47, -36.02 APE9-dihe-na -87.07, -11.18 APE8-dihe-in -151.76, 75.87 APE8-rot-out 169.0 APE67-dihe-in -55.43, -30.79 -91.48, 7.95 APE12-dist-in 9.2894 APE11-dist-in 10.2065 APE10-dist-out 13.9989 APE9-dist-out 12.4548 T165E,S171E None None XRAY 1.641 0.199 0.226 A 294.0 287.0 0 28 28 0 [[17, 274]] 1.0 9h8d Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8EA Q92918 7 293 833.0 A1ITA:301 Type1 Inactive DFGin 4.8712 13.6432 None -54.93, -36.87 -153.52, -178.14 -86.71, 13.52 57.7, 54.93 110.72, -162.78 out-out out 13.2442 Saltbr-out 11.9403 HRD-in -64.82, -60.03 68.16, 15.68 out-out-out SNCooo out-out ActLoopNT-out 7.4278 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -56.89, -34.7 APE9-dihe-na -89.78, -12.26 APE8-dihe-in -151.93, 70.96 APE8-rot-out 171.34 APE67-dihe-in -55.35, -30.86 -85.9, 6.53 APE12-dist-in 9.3157 APE11-dist-in 10.4388 APE10-dist-out 14.1035 APE9-dist-out 12.3872 T165E,S171E None None XRAY 1.631 0.195 0.218 A 294.0 287.0 0 28 28 0 [[17, 274]] 1.0 9h8e Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9H8FA Q92918 7 293 833.0 A1ITB:301 Type1 Inactive DFGin 4.7048 13.3779 None -52.93, -40.35 -154.71, -177.86 -83.04, 10.74 51.93, 61.71 106.06, -156.77 out-out out 13.5042 Saltbr-out 12.0544 HRD-in -67.59, -55.04 63.7, 17.96 out-out-out SNCooo out-out ActLoopNT-out 7.3492 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -58.32, -34.33 APE9-dihe-na -89.38, -1.89 APE8-dihe-in -161.32, 73.17 APE8-rot-out 170.41 APE67-dihe-in -57.59, -27.85 -94.08, 8.2 APE12-dist-in 9.1755 APE11-dist-in 10.3049 APE10-dist-out 14.0403 APE9-dist-out 12.3025 T165E,S171E None None XRAY 1.393 0.203 0.246 A 294.0 287.0 0 28 28 0 [[17, 274]] 1.0 9h8f Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A Q92918 6 292 833.0 A1JAF:301 Type1 Inactive DFGin 6.4629 13.7652 None -60.93, -35.58 -154.04, -176.9 -79.86, 1.42 63.88, 19.01 105.02, -157.57 out-out out 13.2797 Saltbr-out 10.7822 HRD-in -74.09, -55.53 70.27, 5.38 out-out-out SNCooo out-out ActLoopNT-out 7.5816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -59.89, -40.77 APE9-dihe-na -92.18, -16.28 APE8-dihe-in -142.86, 74.69 APE8-rot-in 316.27 APE67-dihe-in -56.11, -27.62 -91.41, -1.8 APE12-dist-in 9.8088 APE11-dist-in 11.1344 APE10-dist-out 15.1534 APE9-dist-out 12.6983 T165E,S171E None None XRAY 1.76 0.198 0.226 A 294.0 285.0 2 28 28 0 [[17, 274]] 1.0 9qt6 Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0A Q92918 6 302 833.0 B49:9000 Type1 Inactive DFGin 5.141 15.0649 None -69.74, 172.09 -58.45, 155.47 -142.74, 154.55 54.54, 93.56 67.99, -7.56 out-out out 12.8583 Saltbr-out 10.8147 HRD-in -63.9, -48.24 77.74, -8.02 out-out-out SNCooo out-out ActLoopNT-out 10.601 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -51.88, -33.41 APE9-dihe-na -72.94, -17.4 APE8-dihe-in -134.99, 76.22 APE8-rot-in 306.88 APE67-dihe-in -54.91, -28.64 -97.55, -2.9 APE12-dist-out 23.0746 APE11-dist-out 25.0122 APE10-dist-out 24.5939 APE9-dist-out 28.7355 T165E,S171E None None XRAY 2.05 0.202 0.229 A 309.0 289.0 8 28 23 5 [[17, 274]] 1.0 6ng0 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQFA Q92918 6 293 833.0 F97:301 Type1 Inactive DFGin 4.9382 15.0175 None -68.84, 171.73 -65.96, 157.38 -148.76, 145.95 51.62, 92.75 82.89, -6.34 out-out out 12.9477 Saltbr-out 11.4708 HRD-in -70.81, -45.95 79.09, -18.39 out-out-out SNCooo out-out ActLoopNT-out 10.2868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 52.73, 67.51 APE9-dihe-na 130.19, -174.52 APE8-dihe-in -127.23, 115.01 APE8-rot-in 316.68 APE67-dihe-in -61.16, -24.43 -41.69, -51.15 APE12-dist-out 15.3177 APE11-dist-out 16.6482 APE10-dist-out 20.6876 APE9-dist-out 21.3856 None None None XRAY 2.246 0.21 0.255 A 297.0 282.0 6 28 22 6 [[17, 274]] 1.0 6cqf Homo sapiens STE_MAP4K1_HUMAN STE 4e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7R9LA Q92918 7 293 833.0 2YE:60301 Type1 Inactive DFGin 5.3709 15.8708 None -79.3, 179.17 -65.19, 145.46 -137.47, 150.51 63.11, 101.31 78.13, -24.94 out-out out 13.2561 Saltbr-out 11.1556 HRD-in -72.62, -38.36 76.08, -17.52 out-out-out SNCooo out-out ActLoopNT-out 9.2967 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -49.77 APE9-dihe-na 168.11, -141.43 APE8-dihe-in -134.99, 123.61 APE8-rot-in 309.2 APE67-dihe-in -71.83, -29.15 -51.51, -37.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.9508 APE9-dist-out 20.5671 None None None XRAY 2.332 0.23 0.284 A 297.0 281.0 6 28 22 6 [[17, 274]] 1.0 7r9l Homo sapiens STE_MAP4K1_HUMAN STE 4e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26A Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.1647 15.6986 None -90.65, 167.41 -51.45, 151.26 -138.89, 999.0 46.52, 93.57 999.0, 999.0 out-out out 13.6491 Saltbr-out 12.2657 HRD-in -70.63, -54.99 86.79, -28.34 out-out-out SNCooo out-out ActLoopNT-out 11.4078 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -80.69, -41.73 APE9-dihe-na 172.07, -144.25 APE8-dihe-in -123.38, 126.59 APE8-rot-in 309.45 APE67-dihe-in -64.56, -28.61 -52.67, -44.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.7601 S171A,G191C None None XRAY 2.3 0.263 0.298 A 287.0 280.0 7 28 25 3 [[17, 274]] 1.0 7l26 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26B Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.0526 15.9102 None -91.19, 163.6 -51.51, 146.14 -129.86, 999.0 50.48, 91.75 999.0, 999.0 out-out out 13.3954 Saltbr-out 10.5251 HRD-in -70.31, -53.37 86.88, -29.66 out-out-out SNCooo out-out ActLoopNT-out 11.6433 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, -41.02 APE9-dihe-na -160.51, -140.31 APE8-dihe-in -120.3, 127.28 APE8-rot-in 312.21 APE67-dihe-in -60.79, -31.57 -54.68, -45.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.9772 S171A,G191C None None XRAY 2.3 0.263 0.298 B 287.0 275.0 12 28 21 7 [[17, 274]] 1.0 7l26 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26C Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.2388 15.7125 None -90.03, 164.23 -51.57, 154.12 -136.67, 999.0 47.02, 92.8 999.0, 999.0 out-out out 13.5186 Saltbr-out 12.2111 HRD-in -69.66, -55.84 84.96, -26.68 out-out-out SNCooo out-out ActLoopNT-out 11.3557 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -82.36, -41.22 APE9-dihe-na 172.52, -152.31 APE8-dihe-in -119.13, 126.23 APE8-rot-in 306.88 APE67-dihe-in -64.39, -28.24 -51.56, -46.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.6383 S171A,G191C None None XRAY 2.3 0.263 0.298 C 287.0 280.0 7 28 25 3 [[17, 274]] 1.0 7l26 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L26D Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.1782 15.7241 None -92.34, 166.71 -52.02, 146.05 -132.39, 999.0 51.2, 93.07 999.0, 999.0 out-out out 13.0641 Saltbr-out 11.4708 HRD-in -69.0, -53.47 85.02, -28.41 out-out-out SNCooo out-out ActLoopNT-out 10.8745 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -61.1, -36.36 APE9-dihe-na -126.65, -143.86 APE8-dihe-in -116.21, 125.85 APE8-rot-in 315.3 APE67-dihe-in -62.16, -30.12 -53.98, -45.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.6829 S171A,G191C None None XRAY 2.3 0.263 0.298 D 287.0 275.0 12 28 21 7 [[17, 274]] 1.0 7l26 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L25A Q92918 7 294 833.0 XHS:301 Type1 Inactive DFGin 4.8827 15.036 None -55.28, -37.86 -159.35, -176.67 -80.39, 10.23 63.68, 79.5 109.4, -154.39 out-out out 13.3566 Saltbr-out 10.9871 HRD-in -68.56, -54.21 74.19, 0.12 out-out-out SNCooo out-out ActLoopNT-out 6.9298 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -67.83, -24.29 APE9-dihe-na 79.98, -160.78 APE8-dihe-in -62.61, 131.99 APE8-rot-out 193.6 APE67-dihe-in -64.53, -27.32 -96.3, 1.86 APE12-dist-in 12.7847 APE11-dist-in 12.3273 APE10-dist-out 11.3185 APE9-dist-out 9.2138 S171A,G191C None None XRAY 1.85 0.187 0.227 A 289.0 288.0 0 28 28 0 [[17, 274]] 1.0 7l25 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7L25B Q92918 6 293 833.0 XHS:301 Type1 Inactive DFGin 4.6918 15.1944 None -55.03, -37.48 -157.98, -176.29 -82.32, 12.4 61.67, 77.66 107.44, -152.88 out-out out 14.0546 Saltbr-out 11.4554 HRD-in -67.3, -54.15 74.75, -2.09 out-out-out SNCooo out-out ActLoopNT-out 6.9385 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -67.95, -23.75 APE9-dihe-na 79.88, -158.91 APE8-dihe-in -63.36, 133.86 APE8-rot-out 194.95 APE67-dihe-in -65.2, -27.32 -96.05, 0.4 APE12-dist-in 12.7497 APE11-dist-in 12.1983 APE10-dist-out 11.4623 APE9-dist-out 9.2011 S171A,G191C None None XRAY 1.85 0.187 0.227 B 289.0 288.0 0 28 28 0 [[17, 274]] 1.0 7l25 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7SIUA Q92918 5 294 833.0 9ID:60901 Type1.5_Back Inactive DFGin 3.8375 13.8946 None -51.62, -38.18 -156.43, -174.28 -96.36, 21.52 50.92, 94.98 81.37, -133.4 out-out out 13.4182 Saltbr-out 9.847 HRD-in -75.88, -56.67 70.34, 5.7 out-out-out SNCooo out-out ActLoopNT-out 6.9827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -60.93, -38.93 APE9-dihe-na 77.72, -173.74 APE8-dihe-in -55.84, 129.92 APE8-rot-out 190.44 APE67-dihe-in -64.04, -19.87 -98.67, -1.07 APE12-dist-out 14.7422 APE11-dist-in 11.9426 APE10-dist-out 11.923 APE9-dist-out 18.0514 None None None XRAY 1.786 0.187 0.205 A 310.0 290.0 0 28 28 0 [[17, 274]] 1.0 7siu Homo sapiens STE_MAP4K1_HUMAN STE 4e-91 310.9 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 7SIUB Q92918 16 294 833.0 9ID:60301 Type1.5_Back Inactive DFGin 5.0764 13.4832 None -53.44, -36.92 -155.11, -179.05 -87.99, 18.37 47.54, 74.7 106.16, -161.65 out-out out 12.3832 Saltbr-out 8.7904 HRD-in -71.24, -52.8 63.02, 13.42 out-out-out SNCooo out-out ActLoopNT-out 7.1653 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -100.2, -45.71 APE9-dihe-na 128.51, -162.4 APE8-dihe-in -63.73, 151.22 APE8-rot-out 52.58 APE67-dihe-in -59.58, -25.5 -100.41, 4.16 APE12-dist-out 16.9549 APE11-dist-out 16.6118 APE10-dist-out 17.1001 APE9-dist-out 21.748 None None None XRAY 1.786 0.187 0.205 B 310.0 279.0 0 28 28 0 [[17, 274]] 1.0 7siu Homo sapiens STE_MAP4K1_HUMAN STE 4e-91 310.9 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE OXSR1 OXSR1_HUMAN 2VWIA O95747 13 292 527.0 ANP:1294 ATPlike Inactive DFGin 8.898 15.6012 None -61.18, 158.62 -55.34, 143.64 -131.37, -0.25 74.39, 103.15 -56.05, -46.66 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.19, -49.86 82.28, -11.12 none-out-out SNCnoo out-out ActLoopNT-out 5.9984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.6 APE8-dihe-in -114.29, 105.56 APE8-rot-out 57.55 APE67-dihe-in -58.83, -26.11 -92.35, 9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.1357 None None None XRAY 2.15 0.253 0.287 A 303.0 237.0 43 33 18 15 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 4O0TB Q13153 255 542 545.0 No_ligand No_ligand Inactive DFGin 8.1487 13.6047 None -152.82, 167.65 64.98, 77.89 -160.54, 999.0 57.61, 97.43 999.0, 999.0 out-out out 11.064 Saltbr-out 8.0427 HRD-in -68.58, -49.06 70.12, -10.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -113.09, 110.46 APE9-dihe-na 88.48, 133.73 APE8-dihe-in -75.78, 128.16 APE8-rot-in 298.99 APE67-dihe-out -65.51, -17.68 -81.05, 73.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.689 None None None XRAY 2.6 0.217 0.265 B 300.0 280.0 8 28 20 8 [[270, 521]] 1.0 4o0t Homo sapiens STE_PAK1_HUMAN STE 3.4e-94 320.9 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 3Q4ZB Q13153 250 541 545.0 No_ligand No_ligand Inactive DFGin 8.0015 14.8016 None -130.95, 172.79 58.85, 58.79 -133.76, 999.0 55.71, 98.96 999.0, 999.0 out-none out 11.7739 Saltbr-none 999.0 HRD-in -65.63, -50.79 80.23, -14.67 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -106.94, -63.76 APE9-dihe-na -80.08, 161.6 APE8-dihe-in -94.98, 117.43 APE8-rot-in 294.62 APE67-dihe-out -66.0, -21.92 -79.94, 65.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0344 S259I,K299R,D389N,L516I None None XRAY 1.887 0.186 0.231 B 306.0 279.0 13 28 19 9 [[270, 521]] 1.0 3q4z Homo sapiens STE_PAK1_HUMAN STE 2e-93 318.4 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 7VTOB Q13153 255 542 545.0 107:601 Type1 Inactive DFGin 7.5191 14.7279 None -159.98, 174.54 62.98, 54.4 -135.2, 999.0 55.36, 102.9 999.0, 999.0 out-out out 11.3279 Saltbr-out 10.0201 HRD-in -69.73, -51.99 75.23, -8.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -62.21, -39.34 APE9-dihe-na 160.98, -155.85 APE8-dihe-out 82.87, 12.18 APE8-rot-out 62.27 APE67-dihe-in -60.81, -30.13 -80.78, 2.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6877 None TPO423 TPO423 XRAY 2.59 0.236 0.252 B 301.0 278.0 10 28 18 10 [[270, 521]] 1.0 7vto Homo sapiens STE_PAK1_HUMAN STE 1.7e-94 321.9 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5DEYB Q13153 255 542 545.0 59T:601 Type1 Inactive DFGin 7.3498 15.4583 None -123.29, 170.33 -82.44, 174.75 -121.32, 55.91 7.6, 122.84 -96.3, -43.82 out-out out 11.7695 Saltbr-out 9.8581 HRD-in -72.29, -49.87 79.14, -22.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -79.22, -70.08 APE9-dihe-na -89.37, 158.31 APE8-dihe-in -85.28, 117.06 APE8-rot-in 296.79 APE67-dihe-out -66.47, -20.46 -79.34, 69.72 APE12-dist-out 19.4815 APE11-dist-out 16.9726 APE10-dist-out 15.3171 APE9-dist-out 12.9671 D389N,T423E None None XRAY 2.1 0.186 0.228 B 297.0 281.0 7 28 21 7 [[270, 521]] 1.0 5dey Homo sapiens STE_PAK1_HUMAN STE 3.3e-94 321.0 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 5IMEB Q13153 250 541 545.0 6BZ:60601 Type1 Inactive DFGin 6.7938 15.4227 None -141.05, 172.61 52.99, 75.91 -151.54, 999.0 56.92, 93.17 999.0, 999.0 out-out out 12.9033 Saltbr-out 9.9854 HRD-in -70.09, -49.96 77.67, -19.32 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -67.92, -63.94 APE9-dihe-na -112.92, 178.31 APE8-dihe-in -97.52, 114.89 APE8-rot-in 302.24 APE67-dihe-out -63.71, -21.19 -77.9, 63.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7136 None None None XRAY 2.217 0.226 0.263 B 300.0 280.0 12 28 20 8 [[270, 521]] 1.0 5ime Homo sapiens STE_PAK1_HUMAN STE 3.4e-94 320.9 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4FIGB O96013 298 590 591.0 ANP:602 ATPlike Inactive DFGin 5.9786 13.8453 None -136.1, -40.27 -82.41, 70.29 -85.54, 12.48 305.29, 106.7 -66.77, -24.27 in-in in 7.0074 Saltbr-in 3.0472 HRD-in -63.37, -48.9 73.21, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.9294 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.8, 141.64 APE9-dihe-na 130.69, -165.45 APE8-dihe-in -110.43, 122.9 APE8-rot-in 324.7 APE67-dihe-in -77.33, -31.89 -29.23, -51.11 APE12-dist-in 9.7059 APE11-dist-in 11.7431 APE10-dist-in 5.9203 APE9-dist-in 3.3864 None SEP474 SEP474 XRAY 3.01 0.197 0.221 B 346.0 293.0 0 28 28 0 [[321, 572]] 1.0 4fig Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK10 STK10_HUMAN 5AJQA O94804 24 312 968.0 DB8:800 Type1 Inactive DFGin 6.2593 15.7439 None -120.59, 174.2 81.32, -56.36 57.24, 29.42 287.8, 79.18 102.53, -17.28 out-out out 10.7485 Saltbr-out 10.9466 HRD-in -68.33, -48.71 84.04, -21.17 out-out-out SNCooo out-out ActLoopNT-out 12.5732 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -85.91, 130.23 APE9-dihe-na 91.1, 7.46 APE8-dihe-in -59.1, 130.74 APE8-rot-in 288.9 APE67-dihe-out -66.14, -20.66 -86.49, 69.24 APE12-dist-none 999.0 APE11-dist-out 18.6923 APE10-dist-out 14.1461 APE9-dist-out 10.6821 None None None XRAY 2.2 0.219 0.257 A 295.0 280.0 9 28 22 6 [[36, 294]] 1.0 5ajq Homo sapiens STE_STK10_HUMAN STE 1.9e-94 321.7 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5AJQB O94804 25 312 968.0 DB8:800 Type1 Inactive DFGin 6.2863 15.9394 None -120.49, 173.38 83.25, -57.95 53.22, 23.51 288.78, 77.4 -62.81, -49.77 out-none out 10.8902 Saltbr-none 999.0 HRD-in -69.73, -48.6 82.63, -20.29 none-out-none SNCnon out-none ActLoopNT-out 6.6725 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 83.37 APE8-rot-in 290.95 APE67-dihe-in -67.97, -24.14 -101.21, 28.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.219 0.257 B 295.0 267.0 21 28 15 13 [[36, 294]] 1.0 5ajq Homo sapiens STE_STK10_HUMAN STE 1.9e-94 321.7 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 4O27B Q9Y6E0 30 309 443.0 ADP:60500 ATPlike Inactive DFGin 4.8671 13.8197 None -148.38, -173.28 56.25, -124.14 31.74, 82.19 64.76, 101.5 98.89, -78.6 in-in in 8.9372 Saltbr-in 2.9006 HRD-in -80.55, -48.63 69.48, -10.03 in-in-out SNCiio in-out ActLoopNT-in 3.0174 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.0, 177.15 APE9-dihe-na 103.58, 170.34 APE8-dihe-in -99.19, 143.02 APE8-rot-out 34.53 APE67-dihe-in -72.39, -25.42 -54.44, -42.62 APE12-dist-in 9.0284 APE11-dist-in 10.879 APE10-dist-in 5.5618 APE9-dist-in 3.6436 T190E None None XRAY 3.185 0.203 0.26 B 281.0 280.0 0 28 28 0 [[36, 286]] 1.0 4o27 Homo sapiens STE_STK24_HUMAN STE 5.5e-100 339.9 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK26 STK26_HUMAN 3GGFA Q9P289 17 300 416.0 GVD:305 Type1 Inactive DFGin 6.5129 17.533 None -107.18, 8.32 -96.74, 1.83 -77.63, 129.12 182.23, 74.2 -169.36, -175.42 out-out out 13.2679 Saltbr-out 11.9131 HRD-out -112.33, 146.97 -132.0, 153.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.52, -49.61 APE9-dihe-na 109.3, -174.5 APE8-dihe-in -89.03, 130.3 APE8-rot-out 188.7 APE67-dihe-in -59.01, -28.43 -93.03, -11.97 APE12-dist-out 20.7255 APE11-dist-out 20.0751 APE10-dist-out 20.4716 APE9-dist-out 12.3677 None None None XRAY 2.35 0.222 0.277 A 301.0 275.0 9 28 19 9 [[24, 274]] 1.0 3ggf Homo sapiens STE_STK26_HUMAN STE 3.5e-100 340.6 1.0 257.0 257.0 161 162 163 165 167 53 70 74 141 143 142 144.0 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 3GGFB Q9P289 18 297 416.0 GVD:304 Type1 Inactive DFGin 6.381 17.7152 None -107.34, 9.0 -94.45, -5.79 -73.15, 129.62 180.07, 74.63 -158.4, -173.99 out-out out 13.2479 Saltbr-out 12.1703 HRD-out -111.96, 147.3 -128.45, 152.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.97, -49.3 APE9-dihe-na 108.76, -176.86 APE8-dihe-in -86.01, 129.64 APE8-rot-out 192.14 APE67-dihe-in -66.2, -27.4 -96.0, -3.24 APE12-dist-out 20.1506 APE11-dist-out 19.5281 APE10-dist-out 20.0681 APE9-dist-out 11.8722 None None None XRAY 2.35 0.222 0.277 B 301.0 270.0 10 28 18 10 [[24, 274]] 1.0 3ggf Homo sapiens STE_STK26_HUMAN STE 3.5e-100 340.6 1.0 257.0 257.0 161 162 163 165 167 53 70 74 141 143 142 144.0 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE STK3 STK3_HUMAN 4LG4F Q13188 18 310 491.0 No_ligand No_ligand Inactive DFGin 4.7998 15.1909 None -138.38, 162.54 47.11, 83.6 -66.57, 999.0 302.94, 84.23 999.0, 999.0 out-out out 10.7899 Saltbr-out 6.4196 HRD-in -72.45, -47.39 76.74, -5.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -102.3 APE8-dihe-in -134.65, 156.4 APE8-rot-out 45.22 APE67-dihe-in -63.77, -27.55 -98.01, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1214 D146N None None XRAY 2.42 0.194 0.231 F 299.0 276.0 17 28 11 17 [[27, 278]] 1.0 4lg4 Homo sapiens STE_STK3_HUMAN STE 1.9e-100 341.5 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STRADA STRAA_HUMAN 8VSUB Q7RTN6 60 401 431.0 ADP:2001 ATPlike Pseudo DFGin 5.3284 13.7435 None -141.72, 9.36 -84.56, 30.72 -65.1, -14.12 305.81, 3.72 -62.58, -31.2 out-none out 10.2295 Saltbr-none 999.0 HRD-out -66.66, 151.23 -136.62, 153.73 none-in-out SNCnio in-out ActLoopNT-in 2.8656 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -55.51, -37.77 APE9-dihe-na -75.16, -6.37 APE8-dihe-out -108.58, -14.7 APE8-rot-na 180.94 APE67-dihe-in -58.61, -34.89 -50.23, -38.37 APE12-dist-in 8.3418 APE11-dist-out 7.821 APE10-dist-out 13.0573 APE9-dist-out 11.0521 None None None EM 2.86 999.0 999.0 B 429.0 306.0 36 35 35 0 [[69, 379]] 1.0 8vsu Homo sapiens STE_STRADA_HUMAN STE 6.5e-87 297.3 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TNIK TNIK_HUMAN 2X7FE Q9UKE5 14 309 1360.0 824:500 Type1 Inactive DFGin 6.6596 14.7942 None -124.38, 176.52 58.71, 103.53 -115.64, 999.0 286.98, 84.26 999.0, 999.0 in-none in 9.525 Saltbr-none 999.0 HRD-in -65.29, -41.79 67.65, -3.62 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.45 APE8-rot-none 999.0 APE67-dihe-in -51.92, -33.29 -95.18, 3.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 E 326.0 251.0 45 28 10 18 [[25, 289]] 1.0 2x7f Homo sapiens STE_TNIK_HUMAN STE 3.7e-105 356.8 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 6T6DA Q04771 204 499 509.0 MM8:501 Type1 Inactive DFGin 8.3091 13.2837 None -109.51, -81.12 -73.5, 111.71 -110.98, 17.65 271.3, 88.6 -66.37, -17.62 in-in in 8.1368 Saltbr-in 3.4958 HRD-in -71.72, -59.58 84.73, 1.24 in-in-in SNCiii in-in ActLoopNT-in 2.8829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.15, 12.06 APE9-dihe-na -92.9, 178.87 APE8-dihe-in -69.31, 121.79 APE8-rot-in 306.54 APE67-dihe-in -58.18, -27.15 -60.78, -34.02 APE12-dist-in 12.1633 APE11-dist-in 11.7611 APE10-dist-in 6.6141 APE9-dist-in 3.7745 Q207D None None XRAY 2.56 0.224 0.272 A 301.0 292.0 4 32 28 4 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL BRAF BRAF_HUMAN 4XV3B P15056 448 705 766.0 No_ligand No_ligand Inactive DFGin 6.2845 15.0635 None -134.59, -161.64 56.33, 52.08 -63.4, 999.0 279.75, 63.83 999.0, 999.0 in-in in 8.9281 Saltbr-in 3.3244 HRD-in -65.71, -41.29 62.65, 10.76 in-in-out SNCiio in-out ActLoopNT-in 2.9826 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -32.28 APE8-dihe-out -76.54, 7.27 APE8-rot-in 304.4 APE67-dihe-in -61.73, -25.86 -63.95, -33.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7011 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.8 0.26 0.296 B 292.0 225.0 33 30 14 16 [[457, 716]] 1.0 4xv3 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4FK3B P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 5.7722 14.711 None -140.8, -152.47 49.25, 52.94 -56.33, -72.64 272.7, 56.86 47.33, -79.68 in-out in 9.0449 Saltbr-out 5.3726 HRD-in -75.07, -44.36 65.22, -1.5 out-in-out SNCoio in-out ActLoopNT-in 3.1937 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 141.11 APE9-dihe-na 86.3, -24.42 APE8-dihe-out -101.18, 22.22 APE8-rot-out 89.79 APE67-dihe-in -68.94, -26.21 -73.51, -33.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1316 APE9-dist-out 11.411 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.262 0.315 B 292.0 257.0 17 30 17 13 [[457, 716]] 1.0 4fk3 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3OG7B P15056 449 720 766.0 No_ligand No_ligand Inactive DFGin 5.9606 14.3845 None -166.94, -137.57 40.92, 51.52 -52.94, -84.66 283.54, 98.08 68.73, -46.65 in-in in 8.951 Saltbr-in 2.5878 HRD-in -73.27, -47.93 73.19, 0.79 in-in-out SNCiio in-out ActLoopNT-in 2.9692 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.76 APE8-dihe-out -68.94, -9.04 APE8-rot-in 313.5 APE67-dihe-in -62.19, -30.71 -52.08, -39.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0366 K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.45 0.214 0.258 B 289.0 254.0 18 30 16 14 [[457, 716]] 1.0 3og7 Homo sapiens TKL_BRAF_HUMAN TKL 1.2e-83 286.6 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6UUOA P15056 450 722 766.0 QH1:801 Type1 Inactive DFGin 5.4833 13.5755 None -154.98, -157.82 59.8, 46.61 -126.81, 999.0 56.6, 86.97 999.0, 999.0 out-none out 10.4408 Saltbr-none 999.0 HRD-out -76.54, 102.1 -78.95, -33.04 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -71.64, -31.02 APE9-dihe-na -70.11, -42.33 APE8-dihe-out -89.38, 32.83 APE8-rot-in 313.94 APE67-dihe-in -71.42, -39.61 -73.97, -40.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.3262 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.288 0.265 0.288 A 284.0 254.0 19 30 16 14 [[457, 716]] 1.0 6uuo Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4H58A P15056 448 722 766.0 10Z:60801 Type1 Inactive DFGin 5.9602 13.7224 None -110.59, -118.32 -39.31, 108.26 -95.89, 11.56 277.46, 88.25 -35.77, -74.73 in-in in 8.3024 Saltbr-in 2.7643 HRD-in -69.13, -43.65 65.49, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.8347 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, 79.67 APE9-dihe-na -70.74, 22.44 APE8-dihe-in -101.01, 94.21 APE8-rot-in 260.42 APE67-dihe-in -50.49, -22.55 -89.83, -41.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.5653 APE9-dist-out 10.3075 None None None XRAY 3.1 0.224 0.272 A 275.0 263.0 12 30 18 12 [[457, 716]] 1.0 4h58 Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3PRFB P15056 448 723 766.0 FP3:727 Type1 Inactive DFGin 6.4282 13.6432 None -169.57, 116.91 168.47, 123.69 -125.85, 47.13 283.69, 79.02 -70.43, 82.93 in-in in 8.1536 Saltbr-in 2.9967 HRD-in -67.72, -35.03 62.32, -6.1 in-out-out SNCioo out-out ActLoopNT-out 5.6019 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -169.48 APE8-dihe-in -103.48, 122.52 APE8-rot-in 275.2 APE67-dihe-in -59.13, -20.14 -98.86, -20.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.5263 None None None XRAY 2.9 0.271 0.31 B 307.0 262.0 14 30 16 14 [[457, 716]] 1.0 3prf Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5CSWA P15056 449 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.5631 13.7249 None -154.89, -152.27 52.45, 58.54 -68.5, 999.0 303.98, 168.7 999.0, 999.0 out-out out 10.269 Saltbr-out 7.4286 HRD-in -64.98, -59.02 86.25, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 30.46 APE8-dihe-out -158.22, 46.88 APE8-rot-in 285.64 APE67-dihe-in -66.32, -23.33 -79.02, -14.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3642 R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.66 0.22 0.282 A 282.0 254.0 19 30 11 19 [[457, 716]] 1.0 5csw Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5ITAB P15056 448 721 766.0 6DC:801 Type1.5_Back Inactive DFGin 5.3633 13.8031 None -122.71, -173.14 61.94, 63.43 -148.55, 999.0 64.56, 89.23 999.0, 999.0 out-in out 10.3514 Saltbr-in 3.533 HRD-in -69.84, -55.2 76.82, -4.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -11.31 APE9-dihe-na -82.19, 19.66 APE8-dihe-out -126.85, 23.68 APE8-rot-in 305.8 APE67-dihe-in -61.03, -25.66 -65.06, -28.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3333 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 1.95 0.197 0.244 B 297.0 252.0 22 30 12 18 [[457, 716]] 1.0 5ita Homo sapiens TKL_BRAF_HUMAN TKL 5.7e-84 287.8 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2UA P15056 449 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.7852 13.8715 None -154.67, -156.07 52.1, 63.13 -70.26, 999.0 290.51, 178.01 999.0, 999.0 out-none out 10.2704 Saltbr-none 999.0 HRD-in -70.43, -53.73 79.13, -11.56 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, -132.33 APE9-dihe-na -124.36, 116.11 APE8-dihe-in -169.83, 67.75 APE8-rot-in 288.88 APE67-dihe-in -62.03, -24.27 -79.94, -15.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4864 None None None XRAY 3.78 0.282 0.309 A 283.0 255.0 18 30 12 18 [[457, 716]] 1.0 6v2u Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MBJA P15056 448 723 766.0 DFS:801 Type1.5_Back Inactive DFGin 5.0397 14.1722 None -105.17, -97.55 -92.89, 45.25 -92.17, -5.13 71.79, 75.67 -66.15, 168.52 out-out out 11.9053 Saltbr-out 10.1254 HRD-in -75.95, -40.1 71.4, -7.47 out-out-out SNCooo out-out ActLoopNT-out 8.6902 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na 173.82, -65.98 APE9-dihe-na -61.43, -19.22 APE8-dihe-in -120.24, 91.44 APE8-rot-out 31.9 APE67-dihe-in -51.31, -26.45 -118.43, -32.49 APE12-dist-none 999.0 APE11-dist-out 14.5191 APE10-dist-out 17.7046 APE9-dist-out 11.0704 None None None XRAY 3.6 0.276 0.328 A 304.0 269.0 7 30 23 7 [[457, 716]] 1.0 4mbj Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MBJB P15056 448 723 766.0 DFS:801 Type1.5_Back Inactive DFGin 5.0227 14.1491 None -106.4, -95.1 -95.18, 47.42 -92.84, -5.68 72.56, 75.57 -66.19, 170.04 out-out out 11.925 Saltbr-out 10.2011 HRD-in -72.66, -45.72 76.66, -7.37 out-out-out SNCooo out-out ActLoopNT-out 8.7036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na 171.46, -66.25 APE9-dihe-na -61.77, -19.59 APE8-dihe-in -119.83, 90.82 APE8-rot-out 33.61 APE67-dihe-in -51.95, -27.84 -118.81, -32.64 APE12-dist-in 11.2516 APE11-dist-out 14.4922 APE10-dist-out 17.6929 APE9-dist-out 11.058 None None None XRAY 3.6 0.276 0.328 B 304.0 276.0 0 30 30 0 [[457, 716]] 1.0 4mbj Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 8TVMD Q9NWZ3 164 459 460.0 VDC:501 Type1 Inactive DFGin 7.8031 14.7146 None -126.76, 170.55 55.84, 64.27 -89.21, 999.0 333.58, 116.07 999.0, 999.0 in-out in 9.0975 Saltbr-out 4.7491 HRD-in -67.23, -50.36 76.24, -8.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -109.51, 116.74 APE9-dihe-na 179.74, -172.21 APE8-dihe-in -111.79, 118.52 APE8-rot-out 41.22 APE67-dihe-in -67.21, -19.62 -56.37, -42.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.276 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 D 307.0 277.0 19 30 19 11 [[183, 456]] 1.0 8tvm Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97B Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.2944 14.2173 None -136.34, -175.59 46.99, 62.58 -120.73, 999.0 61.34, 86.78 999.0, 999.0 in-in in 9.393 Saltbr-in 2.9962 HRD-in -71.9, -50.3 83.45, -13.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -128.91, -19.36 APE9-dihe-na -55.91, 145.79 APE8-dihe-in -64.15, 91.3 APE8-rot-in 291.9 APE67-dihe-in -57.49, -34.64 -51.29, -30.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1454 D311N None None XRAY 2.65 0.206 0.251 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u97 Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AB Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.6327 14.406 None -136.0, 173.79 77.97, 80.6 -165.88, 999.0 67.94, 103.04 999.0, 999.0 in-in in 9.4018 Saltbr-in 2.9242 HRD-in -69.54, -47.75 75.57, 5.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -138.84, -18.64 APE9-dihe-na -63.49, 153.65 APE8-dihe-in -64.27, 92.38 APE8-rot-in 304.32 APE67-dihe-in -63.41, -26.11 -54.68, -17.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3588 D311N None None XRAY 2.8 0.185 0.24 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u9a Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LIMK1 LIMK1_HUMAN 5HVKC P53667 329 633 647.0 ANP:60701 ATPlike Inactive DFGin 6.0783 13.9339 None -149.69, 172.69 -101.87, 169.41 -110.21, 23.25 306.34, 92.8 -73.91, -25.16 in-out in 7.8911 Saltbr-out 3.6442 HRD-in -72.39, -44.63 59.79, 17.6 out-in-in SNCoii in-in ActLoopNT-in 3.0698 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.53, 148.22 APE9-dihe-na 140.89, 172.08 APE8-dihe-in -72.12, 119.75 APE8-rot-na 199.66 APE67-dihe-in -64.48, -35.33 -54.5, -33.22 APE12-dist-in 8.6689 APE11-dist-in 11.1988 APE10-dist-in 5.8992 APE9-dist-in 3.5423 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 C 315.0 291.0 14 42 28 14 [[339, 606]] 1.0 5hvk Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5NXCL P53667 330 632 647.0 9DB:60701 Type1 Inactive DFGin 6.1921 12.9336 None -122.26, 162.54 70.04, 26.42 -74.72, 999.0 43.09, 84.18 999.0, 999.0 out-out out 14.186 Saltbr-out 16.3784 HRD-in -67.42, -56.12 78.54, -18.62 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -87.18 APE8-dihe-in -64.64, 140.22 APE8-rot-na 296.78 APE67-dihe-in -58.15, -27.29 -88.8, 19.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.065 None None None XRAY 2.25 0.242 0.298 L 310.0 272.0 31 42 11 31 [[339, 606]] 1.0 5nxc Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LRRK2 LRRK2_HUMAN 8TZHA Q5S007 627 2522 2527.0 A1N:2601 Type1 Inactive DFGin 5.1887 13.0236 None -82.7, -162.66 -41.82, 136.94 -146.23, 112.92 28.36, 40.7 -50.64, 999.0 in-out in 9.2107 Saltbr-out 4.5645 HRD-in -114.23, -59.07 54.02, 31.73 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.84 APE8-dihe-in -145.38, 140.36 APE8-rot-in 326.06 APE67-dihe-in -90.26, -10.83 -64.13, -43.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.2169 None None None EM 3.9 999.0 999.0 A 2527.0 1485.0 21 26 12 14 [[1875, 2134]] 1.0 8tzh Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 9CHOA Q5S007 543 2527 2527.0 A1N:2701 Type1 Inactive DFGin 6.0139 12.2545 None -87.37, -156.77 -42.12, 141.81 -109.94, -179.33 314.03, 99.42 -59.72, 999.0 in-out in 9.1584 Saltbr-out 5.5545 HRD-in -73.99, -50.39 47.44, 27.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.86 APE8-dihe-in -153.53, 148.49 APE8-rot-in 317.08 APE67-dihe-in -67.05, -9.98 -58.64, -41.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7475 I2020T None None EM 7.8 999.0 999.0 A 1985.0 1792.0 21 26 12 14 [[1875, 2134]] 1.0 9cho Homo sapiens TKL_LRRK2_HUMAN TKL 4.9e-57 199.8 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL MAP3K12 M3K12_HUMAN 9CDXA Q12852 117 397 859.0 A1AZP:501 Type1 Inactive DFGin 6.5428 13.646 None -140.44, 159.48 81.4, 17.88 -85.98, 999.0 46.51, 94.56 999.0, 999.0 out-na out 13.7947 Saltbr-na 13.5441 HRD-in -72.41, -54.6 86.63, -24.49 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -169.44 APE8-dihe-out -120.92, 37.67 APE8-rot-out 62.69 APE67-dihe-in -60.76, -27.81 -70.5, -18.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6787 None None None XRAY 2.38 0.234 0.284 A 300.0 265.0 16 27 11 16 [[118, 372]] 1.0 9cdx Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
TKL MAP3K7 M3K7_HUMAN 8GW3A O43318 27 497 606.0 No_ligand No_ligand Inactive DFGin 6.6472 11.7225 None -119.33, 8.38 -158.05, 154.61 -116.24, 147.16 288.24, 68.47 -75.8, 166.21 out-out out 13.9572 Saltbr-out 9.2042 HRD-in -71.65, -49.3 87.44, -14.15 out-out-out SNCooo out-out ActLoopNT-out 10.0952 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -82.82, -0.21 APE9-dihe-na 77.02, 24.75 APE8-dihe-out -104.16, 8.77 APE8-rot-in 301.46 APE67-dihe-in -66.78, -13.89 -61.71, -40.48 APE12-dist-in 12.1847 APE11-dist-out 14.8778 APE10-dist-out 9.0724 APE9-dist-out 10.7885 None None None XRAY 2.05 0.223 0.258 A 326.0 277.0 0 25 25 0 [[36, 286]] 1.0 8gw3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 5JH6A O43318 31 496 606.0 T92:60601 Type1 Inactive DFGin 10.5293 14.5522 None -137.04, 121.24 -83.75, 119.82 52.98, 999.0 303.28, 108.15 999.0, 999.0 out-out out 10.4819 Saltbr-out 6.598 HRD-in -75.23, -38.87 70.62, -74.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 61.21 APE8-dihe-out -98.25, 8.68 APE8-rot-in 298.96 APE67-dihe-in -65.25, -26.33 -63.14, -30.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8877 None None None XRAY 2.365 0.227 0.253 A 314.0 255.0 18 25 11 14 [[36, 286]] 1.0 5jh6 Homo sapiens TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 5GJGA O43318 31 496 606.0 6V5:60601 Type1 Inactive DFGin 5.2837 13.1578 None -118.05, 171.86 68.2, 36.7 -74.01, 999.0 61.15, 90.63 999.0, 999.0 out-out out 15.749 Saltbr-out 14.4672 HRD-in -70.48, -40.96 66.77, -23.12 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 72.06 APE8-dihe-out -80.43, -1.77 APE8-rot-in 291.81 APE67-dihe-in -68.91, -20.48 -57.04, -35.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7194 None None None XRAY 2.61 0.183 0.221 A 315.0 259.0 14 25 11 14 [[36, 286]] 1.0 5gjg Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL RAF1 RAF1_HUMAN 8CPDA P04049 341 626 648.0 No_ligand No_ligand Inactive DFGin 6.2527 14.8427 None -88.44, -129.65 -68.47, 153.64 -115.46, 32.54 280.62, 22.29 -59.2, -38.85 in-in in 8.9962 Saltbr-in 3.2393 HRD-out -71.21, -9.87 61.06, -133.06 in-in-out SNCiio in-out ActLoopNT-in 3.3344 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -31.3 APE9-dihe-na -64.2, -40.67 APE8-dihe-in -125.25, 125.51 APE8-rot-in 293.24 APE67-dihe-in -70.13, -31.13 -109.07, 11.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.0605 APE9-dist-out 15.3926 Y341D SEP621 SEP621 EM 3.46 999.0 999.0 A 648.0 269.0 17 30 18 12 [[349, 608]] 1.0 8cpd Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CPDB P04049 341 626 648.0 No_ligand No_ligand Inactive DFGin 6.3243 14.7834 None -88.37, -130.06 -68.25, 153.07 -115.22, 33.93 283.48, 10.19 -59.44, -38.94 in-in in 8.9968 Saltbr-in 3.2413 HRD-out -70.18, -11.24 60.41, -132.52 in-in-out SNCiio in-out ActLoopNT-in 3.2815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -32.01 APE9-dihe-na -64.34, -40.91 APE8-dihe-in -123.99, 124.82 APE8-rot-in 292.66 APE67-dihe-in -70.59, -30.16 -110.37, 10.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.0602 APE9-dist-out 15.4329 Y341D SEP621 SEP621 EM 3.46 999.0 999.0 B 648.0 269.0 17 30 18 12 [[349, 608]] 1.0 8cpd Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 3OMVA P04049 340 615 648.0 SM5:1 Type1 Inactive DFGin 6.0105 14.0395 None -72.19, -157.95 -69.65, 158.45 -112.95, 18.14 298.92, 73.64 -38.54, -34.68 in-in in 8.8405 Saltbr-in 2.8181 HRD-in -81.59, -27.52 64.4, -79.14 in-in-out SNCiio in-out ActLoopNT-in 3.128 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -67.59, 120.25 APE9-dihe-na -106.5, 137.12 APE8-dihe-in -106.61, 64.59 APE8-rot-out 44.73 APE67-dihe-inflip 112.91, -48.44 -57.65, 161.85 APE12-dist-none 999.0 APE11-dist-in 13.3289 APE10-dist-out 12.1479 APE9-dist-out 10.4545 None None None XRAY 4.0 0.283 0.364 A 307.0 264.0 12 30 18 12 [[349, 608]] 1.0 3omv Homo sapiens TKL_RAF1_HUMAN TKL 3.7e-81 278.6 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFA P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9193 13.7979 None -77.69, -137.87 -62.1, 150.83 -123.34, 43.11 304.09, 90.48 -53.76, -47.63 in-out in 8.5922 Saltbr-out 6.6899 HRD-in -62.51, -43.32 69.96, -9.45 out-in-out SNCoio in-out ActLoopNT-in 2.8262 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.92, 40.68 APE8-dihe-in -131.33, 94.1 APE8-rot-out 59.25 APE67-dihe-inflip 81.42, -0.92 -97.97, 165.62 APE12-dist-in 7.3494 APE11-dist-in 11.6311 APE10-dist-in 6.9434 APE9-dist-out 10.1571 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 A 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFB P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9191 13.7979 None -77.67, -137.85 -62.16, 150.83 -123.29, 43.03 304.08, 90.5 -53.73, -47.64 in-out in 8.5922 Saltbr-out 6.6905 HRD-in -62.53, -43.31 69.92, -9.4 out-in-out SNCoio in-out ActLoopNT-in 2.8268 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.89, 40.65 APE8-dihe-in -131.28, 94.15 APE8-rot-out 59.25 APE67-dihe-inflip 81.39, -0.89 -98.01, 165.61 APE12-dist-in 7.3494 APE11-dist-in 11.631 APE10-dist-in 6.9423 APE9-dist-out 10.1569 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 B 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL RIPK2 RIPK2_HUMAN 5W5JA O43353 9 310 540.0 9WS:401 Type1 Inactive DFGin 6.0636 11.774 None -119.1, 58.24 -81.72, 48.17 -169.21, 999.0 29.16, 78.79 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-out -76.29, 33.51 -93.6, 157.22 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.86 APE8-rot-out 51.78 APE67-dihe-in -59.34, -25.23 -55.53, -13.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 A 310.0 251.0 51 33 10 23 [[18, 292]] 1.0 5w5j Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5W5JB O43353 10 311 540.0 9WS:401 Type1 Inactive DFGin 10.6638 12.427 None -117.65, 82.68 -113.99, 168.64 -106.24, 999.0 178.58, 75.53 999.0, 999.0 out-none out 12.7338 Saltbr-none 999.0 HRD-none 999.0, -168.86 -106.07, -61.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.02 APE8-rot-out 182.83 APE67-dihe-in -59.02, -25.25 -78.75, -12.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.22 0.268 B 310.0 257.0 45 33 10 23 [[18, 292]] 1.0 5w5j Homo sapiens TKL_RIPK2_HUMAN TKL 4.4e-73 252.0 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 6FU5B O43353 5 316 540.0 E7N:400 Type1 Inactive DFGin 5.9966 14.4823 None -152.27, 168.89 72.98, 59.18 -85.18, 999.0 313.99, 145.21 999.0, 999.0 in-in in 8.2541 Saltbr-in 3.2918 HRD-in -67.82, -57.29 58.73, 20.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 33.08 APE8-dihe-out -121.2, 5.37 APE8-rot-out 45.9 APE67-dihe-in -54.25, -32.94 -85.9, -14.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.8037 None None None XRAY 3.26 0.231 0.271 B 317.0 286.0 26 33 11 22 [[18, 292]] 1.0 6fu5 Homo sapiens TKL_RIPK2_HUMAN TKL 4.8e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 9F3VA O43353 9 314 540.0 A1H90:401 Type1 Inactive DFGin 6.1196 11.6318 None -123.15, 40.28 -90.71, 70.0 -87.39, 999.0 300.2, 126.34 999.0, 999.0 out-out out 12.4585 Saltbr-out 11.3915 HRD-out -117.23, 144.8 -142.51, 123.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.92 APE8-rot-out 194.2 APE67-dihe-in -71.3, -18.73 -128.19, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 A 320.0 271.0 35 33 10 23 [[18, 292]] 1.0 9f3v Homo sapiens TKL_RIPK2_HUMAN TKL 5e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 9F3VB O43353 9 315 540.0 A1H90:401 Type1 Inactive DFGin 6.1588 11.1837 None -124.64, 37.34 -86.49, 73.07 -88.12, -171.81 302.83, 123.42 -66.33, -25.78 out-out out 11.9434 Saltbr-out 13.034 HRD-out -117.06, 146.57 -143.26, 122.43 out-out-out SNCooo out-out ActLoopNT-out 9.0527 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.32 APE8-rot-out 190.74 APE67-dihe-in -70.4, -21.68 -126.9, 0.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.943 0.222 0.256 B 320.0 278.0 29 33 15 18 [[18, 292]] 1.0 9f3v Homo sapiens TKL_RIPK2_HUMAN TKL 5e-73 251.9 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR8A O43353 9 310 540.0 XYW:1311 Type1.5_Back Inactive DFGin 6.4925 13.7371 None -145.13, 172.75 65.95, 57.21 -55.82, 999.0 299.0, 99.97 999.0, 999.0 out-out out 11.8351 Saltbr-out 10.7188 HRD-in -72.15, -51.23 60.29, 11.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.34 APE8-dihe-in -100.17, 152.95 APE8-rot-out 191.99 APE67-dihe-in -63.35, -16.88 -126.62, -2.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0407 None None None XRAY 2.79 0.204 0.233 A 326.0 255.0 47 33 11 22 [[18, 292]] 1.0 5ar8 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR ALK ALK_HUMAN 2YJRA Q9UM73 1101 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.3091 14.7033 None -109.22, -156.6 -24.57, 131.48 -106.45, 12.37 294.91, 66.22 -54.96, -56.35 in-in in 7.9428 Saltbr-in 3.1237 HRD-in -78.17, -44.51 78.03, -12.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.23, -22.26 APE9-dihe-in -61.19, 130.79 APE8-dihe-in -74.37, 65.56 APE8-rot-na 28.22 APE67-dihe-in -67.2, -14.23 -60.39, -32.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8552 F1174L None None XRAY 1.9 0.221 0.281 A 342.0 281.0 21 30 16 14 [[1116, 1385]] 1.0 2yjr Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.2 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 6EDLA Q9UM73 1093 1399 1620.0 J4M:1500 Type1 Inactive DFGin 5.7419 13.9986 None -126.77, 7.53 -146.28, 139.77 -129.2, 999.0 286.43, 88.97 999.0, 999.0 in-in in 8.043 Saltbr-in 3.2026 HRD-in -75.33, -45.54 75.3, -3.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -90.79, -15.28 APE9-dihe-in -62.49, 138.06 APE8-dihe-in -76.58, 62.31 APE8-rot-na 33.87 APE67-dihe-in -71.34, -10.1 -42.44, -41.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1154 None None None XRAY 2.799 0.231 0.282 A 322.0 282.0 25 30 14 16 [[1116, 1385]] 1.0 6edl Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5IMXA Q9UM73 1109 1400 1620.0 CZ4:1501 Type1 Inactive DFGin 5.0344 14.4493 None -109.53, -14.09 -148.27, 147.07 -105.7, 146.52 283.91, 86.87 -67.35, -107.72 in-in in 8.0283 Saltbr-in 2.5042 HRD-in -65.65, -55.77 80.57, -2.35 in-out-out SNCioo out-out ActLoopNT-out 7.5579 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.05, -3.8 APE9-dihe-in -82.72, 146.31 APE8-dihe-in -87.12, 68.37 APE8-rot-na 16.28 APE67-dihe-in -69.01, -16.06 -50.43, -36.09 APE12-dist-na 10.9042 APE11-dist-na 15.5625 APE10-dist-na 10.6323 APE9-dist-in 7.972 None None None XRAY 2.12 0.213 0.259 A 327.0 266.0 26 30 20 10 [[1116, 1385]] 1.0 5imx Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.6296 13.8228 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.4822 Saltbr-in 2.8829 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9739 C1097S None None XRAY 2.03 0.211 0.256 A 333.0 288.0 22 30 16 14 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.7474 13.6282 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.5634 Saltbr-in 2.9896 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7127 C1097S None None XRAY 2.03 0.211 0.256 B 333.0 284.0 25 30 15 15 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR AXL UFO_HUMAN 5U6BA P30530 521 813 894.0 7YS:69001 Type1 Inactive DFGin 6.3623 13.5788 None -138.45, -176.55 74.1, -59.44 62.23, 29.92 319.8, 103.87 51.42, 41.79 out-out out 13.7081 Saltbr-out 12.0892 HRD-in -66.09, -54.16 75.27, -12.42 out-out-none SNCoon out-none ActLoopNT-out 9.8826 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -58.78 APE8-rot-na 17.42 APE67-dihe-in -67.55, -5.96 -47.01, -39.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.84 0.212 0.239 A 307.0 270.0 23 30 14 16 [[536, 805]] 1.0 5u6b Homo sapiens TYR_AXL_HUMAN TYR 2.8e-92 314.7 2.0 260.0 259.0 689 690 691 693 695 567 585 589 669 671 670 672.0 731 719 714 713 712 711 710 709 708 621 Tyrosine-protein kinase receptor UFO
TYR AXL UFO_HUMAN 5U6BC P30530 521 813 894.0 7YS:69001 Type1 Inactive DFGin 6.4468 13.7913 None -138.61, -175.97 75.83, -59.43 64.34, 25.07 310.35, 105.78 53.72, 41.47 out-out out 13.6127 Saltbr-out 11.748 HRD-in -65.26, -53.97 74.88, -12.45 out-out-none SNCoon out-none ActLoopNT-out 9.6998 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -86.85 APE8-rot-na 343.56 APE67-dihe-in -67.51, -5.95 -41.15, -42.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.84 0.212 0.239 C 307.0 270.0 23 30 14 16 [[536, 805]] 1.0 5u6b Homo sapiens TYR_AXL_HUMAN TYR 2.8e-92 314.7 2.0 260.0 259.0 689 690 691 693 695 567 585 589 669 671 670 672.0 731 719 714 713 712 711 710 709 708 621 Tyrosine-protein kinase receptor UFO
TYR BTK BTK_HUMAN 3PIYA Q06187 391 658 659.0 585:1 Type1 Inactive DFGin 6.5898 14.8046 None -86.48, 116.32 -39.12, -55.85 -103.57, 159.77 292.78, 91.05 -55.45, 135.27 out-out out 10.5998 Saltbr-out 6.1662 HRD-in -82.22, -47.83 77.57, -19.27 out-out-out SNCooo out-out ActLoopNT-out 14.1198 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.57, 20.38 APE9-dihe-in -77.53, 136.74 APE8-dihe-in -77.13, 67.95 APE8-rot-na 32.82 APE67-dihe-in -63.75, -20.32 -55.08, -51.26 APE12-dist-na 17.7544 APE11-dist-na 17.7304 APE10-dist-na 12.4391 APE9-dist-out 8.1766 None None None XRAY 2.55 0.228 0.295 A 274.0 262.0 6 29 29 0 [[402, 653]] 1.0 3piy Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3PJ2A Q06187 391 659 659.0 04K:1 Type1.5_Back Inactive DFGin 4.8792 13.7655 None -125.57, -174.91 51.36, 35.37 -74.45, 999.0 30.81, 92.87 999.0, 999.0 out-out out 10.8742 Saltbr-out 6.4644 HRD-in -71.49, -54.79 77.51, -7.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.76 APE8-dihe-in -75.06, 65.46 APE8-rot-na 29.28 APE67-dihe-in -67.05, -14.12 -51.89, -45.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1661 None None None XRAY 1.75 0.231 0.263 A 274.0 248.0 21 29 11 18 [[402, 653]] 1.0 3pj2 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR CSK CSK_HUMAN 3D7TA P41240 188 450 450.0 STU:6335 Type1 Inactive DFGin 4.8478 13.7273 None -129.86, -75.48 -112.49, 120.17 -68.38, 132.53 310.55, 71.3 -108.94, 999.0 in-in in 9.7085 Saltbr-in 3.505 HRD-in -84.81, -41.33 76.65, -6.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.32 APE8-rot-na 27.67 APE67-dihe-in -57.33, -30.65 -43.31, -55.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K361A,K362A None None XRAY 2.899 0.239 0.278 A 269.0 249.0 14 25 11 14 [[195, 442]] 1.0 3d7t Homo sapiens TYR_CSK_HUMAN TYR 5.7e-87 297.2 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR EGFR EGFR_HUMAN 4RIWB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9474 14.5093 None -144.94, -140.84 60.54, -94.56 67.75, 16.38 293.55, 125.63 -72.75, -24.64 in-in in 8.962 Saltbr-in 2.5768 HRD-out -81.5, 87.13 -71.92, 10.44 in-in-none SNCiin in-none ActLoopNT-in 2.9141 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.11 APE8-dihe-in -64.72, 105.47 APE8-rot-na 338.81 APE67-dihe-in -78.09, 0.73 -66.98, -35.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3389 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4riw Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIWD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 6.0156 14.3995 None -147.43, -141.55 60.24, -94.38 68.1, 17.38 294.17, 126.48 -72.23, -23.22 in-in in 8.8454 Saltbr-in 3.0814 HRD-in -78.23, -46.1 60.09, 5.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.64, 111.47 APE9-dihe-in -129.74, 134.09 APE8-dihe-in -62.84, 106.17 APE8-rot-na 337.89 APE67-dihe-in -78.37, 3.33 -65.15, -34.97 APE12-dist-na 11.3973 APE11-dist-na 9.9458 APE10-dist-na 9.7227 APE9-dist-in 6.0148 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4riw Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9187 14.5792 None -139.87, -153.46 71.8, -106.42 74.55, 12.91 300.13, 117.16 -73.01, -18.89 in-in in 8.7784 Saltbr-in 2.8507 HRD-out -79.93, 91.22 -73.37, 9.67 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -57.54, 105.82 APE8-rot-na 336.15 APE67-dihe-in -83.65, 5.55 -71.82, -34.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6445 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4rix Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9838 14.3961 None -138.76, -155.76 70.86, -102.17 73.98, 14.44 299.1, 114.44 -71.0, -18.03 in-in in 8.4327 Saltbr-in 2.1297 HRD-in -75.74, -46.31 59.89, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.8788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.43, 115.77 APE9-dihe-in -128.43, 136.25 APE8-dihe-in -57.6, 106.59 APE8-rot-na 335.5 APE67-dihe-in -81.04, 4.3 -70.58, -32.32 APE12-dist-na 11.3356 APE11-dist-na 10.1436 APE10-dist-na 10.4275 APE9-dist-in 5.9873 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4rix Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9519 14.6551 None -154.99, 131.23 -173.19, -76.87 64.96, 12.46 300.69, 132.23 -71.94, -28.32 in-in in 8.6852 Saltbr-in 2.9501 HRD-out -79.99, 96.69 -77.78, 9.7 in-in-none SNCiin in-none ActLoopNT-in 2.8837 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.59 APE8-dihe-in -76.15, 93.2 APE8-rot-na 346.43 APE67-dihe-in -79.33, 6.83 -64.49, -46.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3497 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4riy Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.8922 14.3982 None -146.72, -160.68 90.34, -82.61 63.94, 14.36 297.22, 112.71 -69.53, -27.12 in-in in 8.3332 Saltbr-in 2.3271 HRD-in -73.91, -45.57 61.02, 4.8 in-in-in SNCiii in-in ActLoopNT-in 2.9763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.34, 113.28 APE9-dihe-in -130.38, 137.58 APE8-dihe-in -69.37, 99.85 APE8-rot-na 344.82 APE67-dihe-in -75.56, 6.57 -58.1, -42.52 APE12-dist-na 11.2323 APE11-dist-na 10.2008 APE10-dist-na 9.9606 APE9-dist-in 6.2575 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4riy Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8EMEA P00533 700 1007 1210.0 No_ligand No_ligand Inactive DFGin 3.9857 13.8386 None -137.24, 168.8 64.53, 119.38 -177.18, 999.0 59.37, 99.1 999.0, 999.0 out-out out 13.8892 Saltbr-out 11.3112 HRD-none 999.0, 999.0 999.0, 84.53 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -73.83, -4.04 999.0, -46.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.32 0.285 0.318 A 331.0 267.0 31 30 9 21 [[712, 970]] 1.0 8eme Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GOPA P00533 676 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.9058 14.6185 None -81.86, 151.27 -44.37, 145.0 -81.84, 77.36 22.41, 114.96 178.29, 999.0 in-na in 8.8504 Saltbr-na 999.0 HRD-in -65.46, -52.27 80.15, -7.53 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.74 APE8-dihe-in -83.3, 83.47 APE8-rot-na 22.34 APE67-dihe-in -72.58, -12.26 -49.6, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.954 K745M None None XRAY 2.8 0.213 0.259 A 361.0 300.0 29 30 12 18 [[712, 970]] 1.0 3gop Homo sapiens TYR_EGFR_HUMAN TYR 3.2e-86 295.0 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXIB P00533 702 1004 1210.0 8BS:1101 Type1 Inactive DFGin 4.6415 14.267 None -127.65, -24.47 -127.47, 108.69 -144.39, 139.56 46.55, 108.56 -178.57, -134.7 out-out out 13.4169 Saltbr-out 12.2007 HRD-in -66.29, -55.89 76.11, -7.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.37 APE8-dihe-in -80.39, 70.42 APE8-rot-na 30.87 APE67-dihe-in -73.29, -5.7 -53.51, -46.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5111 T790M,V948R None None XRAY 3.0 0.278 0.312 B 331.0 274.0 25 30 13 17 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0C P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 5.7951 16.2132 None -140.43, -171.69 57.16, 56.26 -102.57, 14.47 175.77, 70.43 -64.23, -166.18 out-out out 13.304 Saltbr-out 13.7106 HRD-in -68.5, -58.2 83.04, -5.79 out-out-none SNCoon out-none ActLoopNT-out 7.9551 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.7 APE8-dihe-in -78.4, 79.01 APE8-rot-na 31.55 APE67-dihe-in -75.24, -1.85 -59.7, -43.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5896 T790M,V948R None None XRAY 3.1 0.24 0.292 C 331.0 289.0 19 30 16 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7U98A P00533 701 1007 1210.0 M1O:1101 Type1 Inactive DFGin 5.2916 16.4611 None -131.78, -176.31 58.71, 37.78 -55.07, -79.17 157.63, 65.72 -77.42, -26.86 out-out out 13.9765 Saltbr-out 14.699 HRD-in -68.9, -54.72 82.24, -14.81 out-out-none SNCoon out-none ActLoopNT-out 7.1211 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.12 APE8-rot-na 30.49 APE67-dihe-in -75.19, -1.88 -59.47, -39.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.42 0.216 0.244 A 331.0 287.0 20 30 16 14 [[712, 970]] 1.0 7u98 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7ZYQB P00533 700 984 1210.0 V58:1101 Type1 Inactive DFGin 5.1442 13.2951 None -125.84, 171.99 57.78, 57.18 -116.53, 999.0 63.4, 95.28 999.0, 999.0 out-out out 12.8682 Saltbr-out 9.5455 HRD-in -76.02, -55.26 80.29, -12.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.05 APE8-dihe-in -82.27, 69.03 APE8-rot-na 30.38 APE67-dihe-in -72.67, -5.58 -56.39, -41.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4702 T790M,V948R None None XRAY 2.1 0.199 0.223 B 333.0 260.0 25 30 11 19 [[712, 970]] 1.0 7zyq Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JIVA P00533 700 984 1210.0 HKI:1797 Type1.5_Back Inactive DFGin 5.403 14.133 None -99.08, 179.7 43.08, 110.41 179.69, 142.51 59.42, 1.67 76.47, 0.27 out-out out 13.3964 Saltbr-out 10.1083 HRD-in -70.42, -63.2 89.91, -17.22 out-out-none SNCoon out-none ActLoopNT-out 6.9283 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -38.75 APE9-dihe-in -107.53, 155.69 APE8-dihe-in -72.57, 63.91 APE8-rot-na 32.44 APE67-dihe-in -65.29, 3.74 -54.81, -43.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.9317 APE9-dist-in 7.634 T790M None None XRAY 3.5 0.253 0.284 A 328.0 270.0 15 30 16 14 [[712, 970]] 1.0 2jiv Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 4PDOA P29317 590 875 976.0 No_ligand No_ligand Inactive DFGin 5.3167 14.8536 None -130.75, -10.88 -121.71, 138.39 -133.1, 999.0 295.74, 93.17 999.0, 999.0 in-out in 7.9685 Saltbr-out 6.2618 HRD-in -77.55, -48.01 73.27, -11.62 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.79, 137.86 APE9-dihe-in -135.53, 157.5 APE8-dihe-in -79.41, 83.0 APE8-rot-na 28.9 APE67-dihe-in -59.48, -20.71 -53.52, -46.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4933 None None None XRAY 2.104 0.162 0.184 A 299.0 261.0 25 31 13 18 [[613, 873]] 1.0 4pdo Homo sapiens TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 4PDOB P29317 590 875 976.0 No_ligand No_ligand Inactive DFGin 5.2883 14.8974 None -129.53, -11.31 -121.1, 139.25 -134.72, 999.0 294.46, 94.17 999.0, 999.0 in-out in 7.9653 Saltbr-out 6.3734 HRD-in -76.29, -48.44 73.45, -12.19 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.42, 139.51 APE9-dihe-in -133.49, 157.9 APE8-dihe-in -78.68, 83.43 APE8-rot-na 28.65 APE67-dihe-in -60.39, -20.86 -55.6, -45.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4952 None None None XRAY 2.104 0.162 0.184 B 299.0 261.0 25 31 13 18 [[613, 873]] 1.0 4pdo Homo sapiens TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5IA1A P29317 605 888 976.0 ZZL:1001 Type1 Inactive DFGin 5.1042 13.4399 None -130.45, -159.4 76.21, -65.85 93.22, -3.68 287.63, 98.57 73.71, -159.39 in-in in 8.8254 Saltbr-in 3.2305 HRD-in -77.12, -51.78 78.89, -19.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.06 APE8-dihe-in -70.6, 101.8 APE8-rot-na 29.53 APE67-dihe-in -68.76, -14.33 -55.26, -45.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7832 None None None XRAY 2.036 0.183 0.223 A 306.0 261.0 23 31 14 17 [[613, 873]] 1.0 5ia1 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOOA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.5698 16.1391 None -130.25, -171.33 69.56, 59.1 -97.35, 999.0 296.3, 100.28 999.0, 999.0 in-in in 8.8441 Saltbr-in 2.1671 HRD-in -71.72, -46.92 71.95, -7.05 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -147.9 APE8-rot-na 327.21 APE67-dihe-in -60.63, -26.51 -52.34, -45.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F,Y742F None None XRAY 1.25 0.19 0.202 A 373.0 273.0 21 31 10 21 [[621, 880]] 1.0 2qoo Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOFA P29320 595 906 983.0 No_ligand No_ligand Inactive DFGin 5.5743 16.1535 None -128.85, -171.0 68.65, 68.64 -106.11, 999.0 294.29, 100.28 999.0, 999.0 in-in in 8.483 Saltbr-in 2.8656 HRD-in -71.61, -47.44 75.56, -15.18 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.26 APE8-rot-na 32.87 APE67-dihe-in -60.72, -24.96 -52.12, -45.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F None None XRAY 1.2 0.182 0.195 A 373.0 280.0 21 31 10 21 [[621, 880]] 1.0 2qof Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QODA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.547 16.0547 None -131.77, -171.54 68.49, 69.41 -105.64, 999.0 292.55, 100.77 999.0, 999.0 in-in in 8.4586 Saltbr-in 2.9771 HRD-in -71.92, -47.0 75.02, -14.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.55 APE8-rot-na 32.64 APE67-dihe-in -61.1, -23.78 -54.99, -44.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y602F None None XRAY 1.15 0.193 0.206 A 373.0 274.0 21 31 10 21 [[621, 880]] 1.0 2qod Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOIA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.6186 16.2562 None -129.96, -173.84 70.71, 70.9 -110.19, 999.0 293.26, 97.85 999.0, 999.0 in-in in 8.9164 Saltbr-in 2.1555 HRD-in -70.57, -48.64 76.1, -13.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.52 APE8-rot-na 29.06 APE67-dihe-in -60.23, -25.5 -51.78, -44.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.25 0.186 0.192 A 373.0 274.0 21 31 10 21 [[621, 880]] 1.0 2qoi Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOLA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.5305 15.9534 None -127.91, -172.59 67.31, 78.66 -111.91, 999.0 291.32, 93.34 999.0, 999.0 in-in in 8.4262 Saltbr-in 3.1155 HRD-in -70.18, -47.4 74.82, -14.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -61.36, -24.47 999.0, -38.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F,S768G None None XRAY 1.07 0.196 0.211 A 373.0 273.0 22 31 9 22 [[621, 880]] 1.0 2qol Homo sapiens TYR_EPHA3_HUMAN TYR 3.8e-110 373.3 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4P4CA P29320 613 904 983.0 25Q:1001 Type1 Inactive DFGin 5.4825 15.719 None -128.35, -167.77 63.56, 68.23 -102.55, 999.0 294.45, 99.08 999.0, 999.0 in-in in 8.2617 Saltbr-in 2.859 HRD-in -69.2, -49.45 78.06, -9.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.75 APE8-rot-na 27.6 APE67-dihe-in -61.51, -22.54 -51.34, -46.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.599 0.179 0.202 A 361.0 266.0 21 31 10 21 [[621, 880]] 1.0 4p4c Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHB1 EPHB1_HUMAN 7KPMA P54762 611 888 984.0 ADP:901 ATPlike Inactive DFGin 6.1477 15.077 None -129.01, -161.15 68.81, 56.56 -103.91, 999.0 293.32, 103.77 999.0, 999.0 in-in in 7.7435 Saltbr-in 2.7086 HRD-in -77.02, -45.59 75.58, -13.35 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.94 APE8-rot-na 30.04 APE67-dihe-in -77.93, -6.39 -53.89, -41.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR647 PTR647 XRAY 1.608 0.169 0.197 A 279.0 255.0 23 33 10 23 [[619, 880]] 1.0 7kpm Homo sapiens TYR_EPHB1_HUMAN TYR 2.3e-109 370.6 2.0 261.0 260.0 761 762 763 765 767 651 668 672 741 743 742 744.0 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 7KPLA P54762 611 888 984.0 No_ligand No_ligand Inactive DFGin 6.1167 14.504 None -122.5, -147.19 60.66, 72.8 -110.8, 999.0 285.53, 126.95 999.0, 999.0 in-in in 8.7776 Saltbr-in 3.1106 HRD-in -81.07, -50.31 62.2, -0.14 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.78 APE8-dihe-in -69.07, 87.68 APE8-rot-na 25.45 APE67-dihe-in -71.96, -7.05 -54.45, -46.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6029 None PTR647 PTR647 XRAY 2.705 0.202 0.25 A 279.0 256.0 22 33 11 22 [[619, 880]] 1.0 7kpl Homo sapiens TYR_EPHB1_HUMAN TYR 2.3e-109 370.6 2.0 261.0 260.0 761 762 763 765 767 651 668 672 741 743 742 744.0 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 6UMWA P54762 611 889 984.0 CTC:901 Type1.5_Back Inactive DFGin 6.0667 14.8859 None -130.77, -142.58 52.4, 64.34 -100.65, 999.0 280.28, 134.37 999.0, 999.0 in-out in 8.9314 Saltbr-out 5.9984 HRD-in -72.73, -48.51 73.38, -14.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.46 APE8-dihe-in -70.84, 88.26 APE8-rot-na 28.98 APE67-dihe-in -78.1, -4.96 -58.23, -45.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7503 None PTR647 PTR647 XRAY 1.982 0.184 0.221 A 301.0 257.0 22 33 11 22 [[619, 880]] 1.0 6umw Homo sapiens TYR_EPHB1_HUMAN TYR 3e-109 370.3 2.0 261.0 260.0 761 762 763 765 767 651 668 672 741 743 742 744.0 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB2 EPHB2_HUMAN 3ZFMA P29323 615 894 1055.0 No_ligand No_ligand Inactive DFGin 6.0137 15.5935 None -128.47, -176.09 61.51, 84.25 -111.37, 999.0 299.24, 93.21 999.0, 999.0 in-none in 8.6734 Saltbr-none 999.0 HRD-in -65.39, -46.71 66.95, -12.96 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.31 APE8-rot-na 17.62 APE67-dihe-in -74.85, 1.16 -40.98, -50.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.236 0.263 A 298.0 249.0 31 33 10 23 [[621, 882]] 1.0 3zfm Homo sapiens TYR_EPHB2_HUMAN TYR 4.4e-109 369.7 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB3 EPHB3_HUMAN 3ZFYA P54753 632 905 998.0 No_ligand No_ligand Inactive DFGin 5.9131 13.19 None -135.83, 169.47 -155.99, -162.71 44.27, 31.84 325.27, 124.04 -167.07, 999.0 in-out in 8.962 Saltbr-out 5.099 HRD-in -71.74, -46.97 81.22, -17.57 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -13.43 APE9-dihe-in -122.1, 118.82 APE8-dihe-in -85.89, 93.62 APE8-rot-na 31.88 APE67-dihe-in -62.28, -23.15 -49.62, -53.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3289 None None None XRAY 2.2 0.226 0.252 A 298.0 260.0 14 33 25 8 [[633, 894]] 1.0 3zfy Homo sapiens TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 3ZFYB P54753 631 905 998.0 No_ligand No_ligand Inactive DFGin 5.9266 13.1757 None -135.57, 169.17 -156.18, -162.85 44.96, 29.53 325.58, 124.75 -172.35, 999.0 in-none in 8.9457 Saltbr-none 999.0 HRD-in -70.36, -48.08 82.24, -17.0 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -16.99 APE9-dihe-in -120.26, 118.85 APE8-dihe-in -85.02, 93.24 APE8-rot-na 32.99 APE67-dihe-in -63.33, -22.58 -50.36, -52.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3566 None None None XRAY 2.2 0.226 0.252 B 298.0 255.0 20 33 25 8 [[633, 894]] 1.0 3zfy Homo sapiens TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 5L6OA P54753 632 905 998.0 6P6:1001 Type1 Inactive DFGin 6.3789 12.358 None -136.06, 179.55 -169.33, 167.09 62.02, 34.74 338.03, 114.42 -115.47, -169.51 in-in in 8.878 Saltbr-in 3.5045 HRD-in -65.56, -50.53 79.19, -13.37 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.45, 139.28 APE9-dihe-in -128.33, 129.52 APE8-dihe-in -85.6, 95.79 APE8-rot-na 29.74 APE67-dihe-in -63.86, -27.48 -56.29, -41.16 APE12-dist-na 21.3818 APE11-dist-na 17.7016 APE10-dist-na 13.8374 APE9-dist-in 6.5576 A899P None None XRAY 1.88 0.19 0.206 A 298.0 267.0 7 33 29 4 [[633, 894]] 1.0 5l6o Homo sapiens TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
TYR EPHB3 EPHB3_HUMAN 5L6PA P54753 632 905 998.0 6P8:1001 Type1 Inactive DFGin 6.9132 13.5082 None -121.71, 172.7 -177.55, 159.52 60.86, 39.03 330.37, 109.09 -99.35, -138.53 in-out in 8.77 Saltbr-out 3.6125 HRD-in -66.38, -48.41 77.7, -5.2 out-out-in SNCooi out-in ActLoopNT-out 19.8833 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.16, 144.59 APE9-dihe-in -127.94, 122.91 APE8-dihe-in -84.6, 92.12 APE8-rot-na 31.43 APE67-dihe-in -59.89, -19.8 -39.97, -57.64 APE12-dist-na 20.9448 APE11-dist-na 17.4017 APE10-dist-na 14.0235 APE9-dist-in 6.299 A899P None None XRAY 2.26 0.206 0.232 A 298.0 274.0 0 33 33 0 [[633, 894]] 1.0 5l6p Homo sapiens TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
TYR EPHB4 EPHB4_HUMAN 2YN8A P54760 608 888 987.0 STU:1889 Type1 Inactive DFGin 6.4266 14.6174 None -130.9, 178.33 70.32, 85.06 -121.95, 999.0 309.1, 102.44 999.0, 999.0 in-in in 7.5327 Saltbr-in 2.7506 HRD-in -74.77, -43.96 71.71, -21.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.38 APE8-rot-na 24.51 APE67-dihe-in -59.12, -26.62 -41.36, -49.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 A 298.0 253.0 28 33 10 23 [[615, 876]] 1.0 2yn8 Homo sapiens TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8B P54760 606 888 987.0 STU:1889 Type1 Inactive DFGin 6.4286 14.6268 None -131.1, 178.0 70.17, 85.21 -120.37, 999.0 309.66, 103.01 999.0, 999.0 in-in in 7.4864 Saltbr-in 2.7603 HRD-in -75.37, -48.88 76.16, -20.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.61 APE8-rot-na 24.46 APE67-dihe-in -59.58, -26.36 -40.69, -50.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 B 298.0 260.0 23 33 10 23 [[615, 876]] 1.0 2yn8 Homo sapiens TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWUA P54760 609 887 987.0 7X1:1888 Type1 Inactive DFGin 6.0774 15.9237 None -124.83, -150.81 63.15, 75.45 -124.13, 999.0 300.91, 99.28 999.0, 999.0 in-in in 8.0751 Saltbr-in 2.9136 HRD-in -76.46, -48.16 73.47, -11.39 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.21 APE8-dihe-in -73.39, 85.33 APE8-rot-na 28.9 APE67-dihe-in -73.59, -6.79 -48.01, -50.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3579 Y774E None None XRAY 2.0 0.177 0.209 A 302.0 253.0 26 33 11 22 [[615, 876]] 1.0 2vwu Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWVA P54760 606 885 987.0 7X3:1888 Type1 Inactive DFGin 5.9221 15.5979 None -133.23, -172.3 65.63, 73.48 -107.63, 999.0 299.15, 99.0 999.0, 999.0 in-in in 8.5873 Saltbr-in 2.6234 HRD-in -81.9, -48.15 79.25, -19.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 11.23 APE9-dihe-in -83.5, 125.27 APE8-dihe-in -64.05, 86.66 APE8-rot-na 24.68 APE67-dihe-in -70.9, -11.59 -54.32, -49.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6027 Y774E None None XRAY 1.9 0.241 0.287 A 302.0 255.0 25 33 12 21 [[615, 876]] 1.0 2vwv Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2VWWA P54760 609 887 987.0 7X2:1888 Type1 Inactive DFGin 6.066 15.7518 None -127.97, -175.21 79.12, 85.48 -128.75, 999.0 298.95, 96.97 999.0, 999.0 in-in in 8.0597 Saltbr-in 2.9804 HRD-in -81.76, -48.87 81.8, -14.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.85 APE8-dihe-in -74.53, 86.32 APE8-rot-na 30.17 APE67-dihe-in -77.13, -5.49 -50.75, -49.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3504 Y774E None None XRAY 1.9 0.186 0.229 A 302.0 253.0 26 33 11 22 [[615, 876]] 1.0 2vww Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR ERBB2 ERBB2_HUMAN 7JXHB P04626 707 996 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 7.2065 13.5254 None -148.36, -162.08 75.74, -80.61 60.69, 10.97 304.93, 117.3 -60.45, -19.03 out-out out 11.1459 Saltbr-out 7.1946 HRD-in -68.76, -43.51 73.16, -15.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.14, 8.4 APE9-dihe-in -91.45, 135.42 APE8-dihe-in -59.93, 122.28 APE8-rot-na 333.95 APE67-dihe-in -83.25, -7.59 -73.08, -19.15 APE12-dist-na 999.0 APE11-dist-na 10.876 APE10-dist-na 7.7989 APE9-dist-in 5.3721 None None None XRAY 3.27 0.241 0.285 B 326.0 276.0 14 30 16 14 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHC P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.6125 13.3041 None -143.65, -158.56 73.24, -76.65 56.5, 17.37 306.61, 100.9 -65.36, -26.15 out-out out 11.167 Saltbr-out 8.5521 HRD-in -71.63, -45.71 67.47, -11.62 out-in-out SNCoio in-out ActLoopNT-in 2.8423 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.65, -5.59 APE9-dihe-in -76.55, 128.34 APE8-dihe-in -57.68, 119.14 APE8-rot-na 333.73 APE67-dihe-in -84.4, -5.28 -70.79, -17.96 APE12-dist-na 999.0 APE11-dist-na 10.8294 APE10-dist-na 7.7009 APE9-dist-in 5.3788 None None None XRAY 3.27 0.241 0.285 C 326.0 274.0 12 30 18 12 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHD P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.7679 13.3927 None -142.96, -159.37 73.71, -79.68 58.36, 17.86 306.67, 100.24 -64.62, -26.72 out-out out 11.1303 Saltbr-out 5.9863 HRD-in -71.8, -45.74 66.79, -11.56 out-in-none SNCoin in-none ActLoopNT-in 3.0535 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 8.73 APE9-dihe-in -87.17, 130.9 APE8-dihe-in -61.26, 114.35 APE8-rot-na 332.97 APE67-dihe-in -82.22, -4.18 -69.93, -17.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.7783 APE9-dist-in 5.5184 None None None XRAY 3.27 0.241 0.285 D 326.0 283.0 3 30 27 3 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHF P04626 713 991 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.9028 13.9624 None -147.07, -162.69 78.08, -83.21 56.45, 8.27 300.93, 121.19 -58.9, -10.87 out-out out 10.8692 Saltbr-out 6.7281 HRD-in -63.37, -44.43 70.8, -16.12 out-out-none SNCoon out-none ActLoopNT-out 5.435 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.37 APE8-dihe-in -63.96, 121.3 APE8-rot-na 334.12 APE67-dihe-in -82.97, -7.43 -74.51, -19.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.6423 None None None XRAY 3.27 0.241 0.285 F 326.0 262.0 17 30 18 12 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHG P04626 706 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 7.8697 13.8089 None -142.75, -163.19 75.45, -91.2 64.27, 18.94 302.94, 97.25 -68.06, -26.16 out-out out 11.5789 Saltbr-out 7.4558 HRD-in -69.52, -47.34 66.45, -11.89 out-in-none SNCoin in-none ActLoopNT-in 3.4707 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.01 APE8-dihe-in -53.01, 109.02 APE8-rot-na 332.56 APE67-dihe-in -83.03, -4.37 -69.53, -16.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7907 None None None XRAY 3.27 0.241 0.285 G 326.0 273.0 14 30 16 14 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 7JXHH P04626 707 992 1255.0 VOY:1101 Type1.5_Back Inactive DFGin 6.4919 13.3909 None -147.0, -168.64 78.92, -65.16 55.44, -120.37 308.82, 110.24 77.15, -59.63 out-out out 10.4414 Saltbr-out 6.2345 HRD-in -70.56, -45.63 67.17, -12.43 out-in-out SNCoio in-out ActLoopNT-in 2.8816 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.87, 9.88 APE9-dihe-in -95.76, 115.55 APE8-dihe-in -50.25, 109.35 APE8-rot-na 333.22 APE67-dihe-in -82.18, -3.91 -69.96, -16.92 APE12-dist-na 8.8114 APE11-dist-na 10.9517 APE10-dist-na 7.599 APE9-dist-in 5.5459 None None None XRAY 3.27 0.241 0.285 H 326.0 282.0 4 30 30 0 [[720, 978]] 1.0 7jxh Homo sapiens TYR_ERBB2_HUMAN TYR 7.5e-86 293.6 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3PP0A P04626 706 993 1255.0 03Q:1 Type1.5_Back Inactive DFGin 6.1891 12.8909 None -143.24, -161.48 74.0, -72.25 62.71, 12.18 304.07, 105.53 -53.57, -26.07 out-out out 10.8314 Saltbr-out 6.7356 HRD-in -72.52, -43.75 67.05, -6.56 out-in-in SNCoii in-in ActLoopNT-in 2.986 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.93, 133.73 APE9-dihe-in -132.61, 148.93 APE8-dihe-in -81.51, 83.41 APE8-rot-na 32.02 APE67-dihe-in -73.68, -2.45 -53.16, -44.04 APE12-dist-na 999.0 APE11-dist-na 9.4866 APE10-dist-na 9.955 APE9-dist-in 6.4533 M706A,Q711L,M712L None None XRAY 2.25 0.189 0.26 A 338.0 286.0 2 30 28 2 [[720, 978]] 1.0 3pp0 Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3PP0B P04626 706 1009 1255.0 03Q:2 Type1.5_Back Inactive DFGin 6.5295 13.1712 None -149.09, -166.81 85.39, -78.34 67.1, 11.91 301.66, 109.6 -51.94, -39.66 out-out out 10.6441 Saltbr-out 6.7399 HRD-in -69.4, -53.62 79.07, -10.52 out-in-out SNCoio in-out ActLoopNT-in 2.8388 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.46, -6.75 APE9-dihe-in -77.94, 120.44 APE8-dihe-in -61.24, 120.47 APE8-rot-na 332.74 APE67-dihe-in -74.13, -7.61 -67.24, -26.94 APE12-dist-na 999.0 APE11-dist-na 10.6587 APE10-dist-na 7.6218 APE9-dist-in 5.3485 M706A,Q711L,M712L None None XRAY 2.25 0.189 0.26 B 338.0 296.0 2 30 28 2 [[720, 978]] 1.0 3pp0 Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3RCDA P04626 713 1022 1255.0 03P:69001 Type1.5_Back Inactive DFGin 7.3275 12.7836 None -131.6, -178.33 92.87, -78.83 17.87, 80.88 36.71, 96.9 175.62, 84.65 out-out out 12.7748 Saltbr-out 10.1037 HRD-in -81.36, -50.25 83.34, -29.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 32.08 APE8-dihe-in -80.8, 92.84 APE8-rot-na 32.85 APE67-dihe-in -72.62, -9.61 -71.44, -35.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7735 None None None XRAY 3.21 0.227 0.294 A 338.0 278.0 21 30 13 17 [[720, 978]] 1.0 3rcd Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR ERBB2 ERBB2_HUMAN 3RCDC P04626 713 1022 1255.0 03P:69001 Type1.5_Back Inactive DFGin 7.2988 12.8076 None -129.48, -177.14 93.53, -78.44 17.53, 81.66 36.39, 96.61 174.11, 84.1 out-out out 12.7623 Saltbr-out 10.1811 HRD-in -79.56, -52.25 82.81, -26.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 30.75 APE8-dihe-in -78.7, 91.19 APE8-rot-na 32.27 APE67-dihe-in -71.69, -11.86 -69.94, -35.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6837 None None None XRAY 3.21 0.227 0.294 C 338.0 278.0 21 30 13 17 [[720, 978]] 1.0 3rcd Homo sapiens TYR_ERBB2_HUMAN TYR 8.5e-86 293.4 2.0 260.0 259.0 862 863 864 866 868 753 770 774 842 844 843 845.0 904 892 887 886 885 884 883 882 881 799 Receptor tyrosine-protein kinase erbB-2
TYR FGFR1 FGFR1_HUMAN 4F65A P11362 464 765 822.0 0S9:808 Type1 Inactive DFGin 5.6218 13.0799 None -116.38, 166.24 56.16, 50.99 -96.21, 999.0 35.52, 82.62 999.0, 999.0 in-in in 7.9758 Saltbr-in 2.9248 HRD-in -64.44, -52.01 69.63, -13.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.26, 142.02 APE9-dihe-in -87.5, 110.31 APE8-dihe-out -50.81, -23.5 APE8-rot-na 336.61 APE67-dihe-in -69.73, -13.19 -59.55, -23.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.803 C488A,C584S None None XRAY 2.26 0.204 0.235 A 309.0 279.0 23 30 20 10 [[478, 756]] 1.0 4f65 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4NKAB P11362 458 765 822.0 2K7:803 Type1 Inactive DFGin 4.9928 12.588 None -113.09, 172.85 51.3, 36.02 -81.11, 999.0 51.02, 79.07 999.0, 999.0 in-in in 7.7205 Saltbr-in 2.8187 HRD-in -68.57, -53.53 79.69, -21.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -99.94, 158.4 APE9-dihe-in -98.99, 111.75 APE8-dihe-out -53.76, -24.39 APE8-rot-na 331.5 APE67-dihe-in -68.26, -7.43 -55.44, -26.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.4239 C488A,C584S None None XRAY 2.19 0.2 0.228 B 309.0 287.0 21 30 24 6 [[478, 756]] 1.0 4nka Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4F65B P11362 460 763 822.0 0S9:808 Type1.5_Back Inactive DFGin 6.1724 11.7443 None -112.37, 28.01 -137.92, 136.63 -123.39, 999.0 315.19, 98.45 999.0, 999.0 in-in in 7.9279 Saltbr-in 2.9079 HRD-in -72.51, -42.53 62.62, -12.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.78, 143.47 APE9-dihe-in -85.99, 110.74 APE8-dihe-out -51.4, -22.91 APE8-rot-na 337.29 APE67-dihe-in -68.78, -13.01 -59.73, -24.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2572 C488A,C584S None None XRAY 2.26 0.204 0.235 B 309.0 279.0 25 30 23 7 [[478, 756]] 1.0 4f65 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6C18B P11362 466 762 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.466 13.1559 None -121.52, 157.51 52.39, 50.92 -96.25, 999.0 51.2, 88.67 999.0, 999.0 in-in in 8.0231 Saltbr-in 2.9239 HRD-in -68.59, -52.77 77.43, -7.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.06 APE8-rot-na 331.63 APE67-dihe-in -71.45, -6.87 -51.83, -28.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 B 311.0 255.0 42 30 10 20 [[478, 756]] 1.0 6c18 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6MZWB P11362 463 762 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.2433 13.1911 None -113.61, 162.19 59.99, 41.93 -84.77, 999.0 49.28, 82.5 999.0, 999.0 in-in in 7.816 Saltbr-in 2.6843 HRD-in -70.89, -55.55 82.9, -7.56 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-na 29.6 APE67-dihe-in -68.26, -6.41 -48.51, -43.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 B 311.0 258.0 42 30 10 20 [[478, 756]] 1.0 6mzw Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 8U1FB P21802 472 765 821.0 UIM:802 Type1.5_Back Inactive DFGin 6.244 12.7017 None -124.83, 24.9 -143.72, 116.95 -174.75, 141.2 47.25, 98.48 -120.17, -141.34 in-out in 7.1789 Saltbr-out 5.4704 HRD-out -91.63, 125.64 -83.89, -44.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.43 APE8-dihe-in -82.13, 67.06 APE8-rot-na 35.42 APE67-dihe-in -61.84, -12.32 -56.83, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2015 None None None XRAY 3.33 0.269 0.295 B 316.0 268.0 26 30 14 16 [[481, 759]] 1.0 8u1f Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8STGB P21802 472 765 821.0 WCJ:801 Type1.5_Back Inactive DFGin 5.7481 12.473 None -146.69, 51.17 -166.05, 99.26 -159.05, 129.25 42.24, 92.9 -129.91, 121.06 in-out in 7.5175 Saltbr-out 4.9612 HRD-out -109.82, 96.26 -71.43, -48.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 71.23, -15.79 APE9-dihe-in -138.41, 153.88 APE8-dihe-in -76.95, 77.58 APE8-rot-na 30.06 APE67-dihe-in -68.25, -27.71 -60.57, -41.19 APE12-dist-na 23.5958 APE11-dist-na 24.2264 APE10-dist-na 21.8134 APE9-dist-in 7.3025 None None None XRAY 3.79 0.307 0.311 B 317.0 274.0 20 30 20 10 [[481, 759]] 1.0 8stg Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 9U3NB P21802 470 764 821.0 A1ENT:801 Type1.5_Back Inactive DFGin 5.7614 12.952 None -150.15, 37.07 -124.69, 18.17 -79.98, -34.12 48.54, 88.69 -70.14, 999.0 in-in in 7.9398 Saltbr-in 3.3774 HRD-out -109.06, 108.36 -99.86, 137.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -159.89, 170.93 APE9-dihe-in -97.33, 137.9 APE8-dihe-in -78.65, 61.34 APE8-rot-na 34.6 APE67-dihe-in -58.88, -28.65 -55.23, -53.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6586 V564F None None XRAY 3.25 0.283 0.342 B 311.0 272.0 23 30 17 13 [[481, 759]] 1.0 9u3n Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR4 FGFR4_HUMAN 4TYEA P22455 451 753 802.0 No_ligand No_ligand Inactive DFGin 5.829 12.5802 None -91.65, -29.21 -103.02, 104.95 -71.18, -26.95 65.53, 79.96 94.73, -139.66 in-in in 8.2669 Saltbr-in 2.6135 HRD-out -120.78, 153.56 -67.42, -42.5 in-out-out SNCioo out-out ActLoopNT-out 8.3844 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.01 APE8-dihe-in -80.96, 75.64 APE8-rot-na 33.57 APE67-dihe-in -64.71, -19.07 -60.12, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.1877 None None None XRAY 2.8 0.227 0.278 A 311.0 292.0 11 30 23 7 [[467, 745]] 1.0 4tye Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.0214 13.2508 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.3097 Saltbr-out 4.2744 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5xfj Homo sapiens TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.2509 13.8003 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.9065 Saltbr-in 3.5618 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.5407 V550L None None XRAY 2.7 0.27 0.32 A 311.0 269.0 29 30 13 17 [[467, 745]] 1.0 5xff Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.4149 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.7877 Saltbr-in 2.7483 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4055 None None None XRAY 2.352 0.237 0.277 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5jkg Homo sapiens TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR HCK HCK_HUMAN 3VS0A P08631 81 526 526.0 VS0:60602 Type1 Inactive DFGin 5.5705 16.6537 None -129.57, 162.1 -82.47, -42.29 67.42, 124.57 160.77, 70.48 69.5, 30.08 out-out out 14.2453 Saltbr-out 14.6605 HRD-in -88.57, -37.73 75.77, -11.97 out-out-none SNCoon out-none ActLoopNT-out 7.1153 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.1 APE8-rot-na 22.57 APE67-dihe-in -68.2, -25.74 -107.06, -1.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.934 0.295 0.295 A 454.0 428.0 13 29 16 13 [[262, 513]] 1.0 3vs0 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS0B P08631 81 526 526.0 VS0:60602 Type1 Inactive DFGin 6.0642 17.1807 None -111.8, 150.48 -110.07, -32.77 65.61, 113.92 163.11, 68.65 100.74, -23.61 out-out out 14.2153 Saltbr-out 14.3341 HRD-in -78.42, -39.25 73.05, -7.55 out-out-none SNCoon out-none ActLoopNT-out 6.5568 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.88 APE8-rot-na 26.41 APE67-dihe-in -67.85, -25.96 -92.49, -6.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.934 0.295 0.295 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs0 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS1B P08631 81 526 526.0 VSA:60602 Type1 Inactive DFGin 6.7322 16.9114 None -77.82, 121.43 -54.05, 124.88 82.63, -74.78 150.57, 57.75 -49.96, -36.41 out-out out 14.0072 Saltbr-out 14.3647 HRD-in -101.3, -38.37 77.41, -41.31 out-out-none SNCoon out-none ActLoopNT-out 6.7331 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.85 APE8-rot-na 30.48 APE67-dihe-in -65.84, -20.55 -144.01, -39.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.464 0.281 0.281 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs1 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS2B P08631 81 526 526.0 VSB:60601 Type1 Inactive DFGin 4.1152 13.5671 None -172.86, 118.27 -95.57, 158.0 70.94, 64.18 175.32, 32.25 108.45, -126.49 out-out out 14.0308 Saltbr-out 15.5528 HRD-in -134.11, -48.57 73.0, -14.11 out-out-none SNCoon out-none ActLoopNT-out 7.3664 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.96 APE8-rot-na 32.11 APE67-dihe-in -73.24, -13.59 -122.47, 3.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.609 0.279 0.279 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs2 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS7A P08631 81 526 526.0 KS1:60601 Type1 Inactive DFGin 6.7194 17.468 None -90.49, -125.14 -63.27, 78.08 -85.63, 139.18 138.5, 78.54 73.41, 14.52 out-out out 12.6896 Saltbr-out 12.695 HRD-in -99.39, -35.83 68.71, -16.04 out-out-none SNCoon out-none ActLoopNT-out 7.1153 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.21 APE8-rot-na 27.98 APE67-dihe-in -66.27, -13.07 -124.75, -5.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.001 0.29 0.29 A 454.0 432.0 14 29 15 14 [[262, 513]] 1.0 3vs7 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS1A P08631 81 526 526.0 VSA:60602 Type1.5_Back Inactive DFGin 6.3901 17.1455 None -69.87, 118.45 -52.39, 130.08 95.26, -49.41 153.54, 67.46 -76.6, -8.56 out-out out 13.1819 Saltbr-out 15.1558 HRD-in -89.48, -44.64 76.16, -14.14 out-out-none SNCoon out-none ActLoopNT-out 6.893 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.94 APE8-rot-na 32.7 APE67-dihe-in -65.2, -12.86 -62.99, -17.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.464 0.281 0.281 A 454.0 424.0 13 29 16 13 [[262, 513]] 1.0 3vs1 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 1JQHA P08069 984 1286 1367.0 ANP:301 ATPlike Inactive DFGin 5.6898 16.5691 None -66.7, 163.88 -59.45, 151.32 -140.18, 178.07 43.94, 89.38 -106.76, 173.06 in-out in 9.9768 Saltbr-out 6.0561 HRD-in -50.88, -56.96 74.77, -3.78 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.24, 106.81 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -78.96, 121.64 APE8-rot-na 37.96 APE67-dihe-in -60.45, -7.73 -52.46, -43.95 APE12-dist-na 7.1567 APE11-dist-na 11.2997 APE10-dist-na 15.5969 APE9-dist-in 5.8 E979G,Y980S None None XRAY 2.1 0.195 0.219 A 308.0 291.0 12 30 23 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHB P08069 984 1286 1367.0 ANP:302 ATPlike Inactive DFGin 5.6866 16.5538 None -65.78, 164.4 -59.98, 151.89 -140.81, 178.2 43.68, 89.42 -109.69, -174.77 in-out in 9.9884 Saltbr-out 6.0195 HRD-in -51.69, -56.66 74.32, -2.97 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.6, 107.67 APE9-dihe-in -58.75, 135.36 APE8-dihe-in -79.54, 122.52 APE8-rot-na 37.69 APE67-dihe-in -59.25, -7.46 -52.18, -45.28 APE12-dist-na 6.8166 APE11-dist-na 10.9316 APE10-dist-na 15.2162 APE9-dist-in 5.768 E979G,Y980S None None XRAY 2.1 0.195 0.219 B 308.0 287.0 16 30 23 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHC P08069 984 1286 1367.0 ANP:303 ATPlike Inactive DFGin 5.6976 16.5582 None -65.47, 162.73 -58.75, 151.62 -140.8, 179.03 43.87, 88.98 -110.24, -177.72 in-out in 9.9987 Saltbr-out 6.0347 HRD-in -53.2, -57.0 74.59, -2.63 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.9, 107.89 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -79.04, 122.75 APE8-rot-na 38.27 APE67-dihe-in -60.34, -8.42 -53.61, -43.61 APE12-dist-na 6.9265 APE11-dist-na 10.9862 APE10-dist-na 15.2452 APE9-dist-in 5.7735 E979G,Y980S None None XRAY 2.1 0.195 0.219 C 308.0 291.0 12 30 23 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3QQUB P08069 988 1286 1367.0 01P:60001 Type1 Inactive DFGin 7.3126 15.8493 None -33.42, 160.47 -37.99, 116.49 -33.99, 105.39 285.12, 147.4 61.19, -16.27 in-out in 9.1403 Saltbr-out 5.1324 HRD-out -74.87, 134.07 -112.64, 23.07 out-out-in SNCooi out-in ActLoopNT-out 16.4502 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.73, 125.53 APE9-dihe-in -129.43, 153.07 APE8-dihe-in -94.91, 67.38 APE8-rot-na 36.24 APE67-dihe-in -82.46, 4.52 -51.63, -28.48 APE12-dist-na 20.8733 APE11-dist-na 16.3058 APE10-dist-na 12.6306 APE9-dist-in 7.0517 None None None XRAY 2.9 0.273 0.302 B 301.0 288.0 11 30 30 0 [[999, 1268]] 1.0 3qqu Homo sapiens TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3QQUD P08069 989 1285 1367.0 01P:60001 Type1 Inactive DFGin 7.8652 16.3418 None -72.27, 173.4 -41.63, 112.37 -69.49, 2.91 294.86, 82.49 -113.94, 14.31 in-out in 9.3296 Saltbr-out 4.3315 HRD-out -89.46, 130.4 -100.59, 1.17 out-out-out SNCooo out-out ActLoopNT-out 17.3649 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 71.55, 69.22 APE9-dihe-in -124.37, 159.91 APE8-dihe-in -89.12, 68.21 APE8-rot-na 38.62 APE67-dihe-in -73.08, -17.7 -59.12, -27.53 APE12-dist-na 21.9404 APE11-dist-na 19.125 APE10-dist-na 15.1883 APE9-dist-in 7.4577 None None None XRAY 2.9 0.273 0.302 D 301.0 292.0 5 30 30 0 [[999, 1268]] 1.0 3qqu Homo sapiens TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 4D2RA P08069 985 1286 1367.0 DYK:2288 Type1 Inactive DFGin 6.1705 16.2033 None -69.68, 163.13 -53.49, 135.63 -66.9, 144.51 304.26, 163.38 61.31, 29.83 out-out out 10.2666 Saltbr-out 6.6469 HRD-in -70.04, -49.33 73.87, -13.98 out-out-in SNCooi out-in ActLoopNT-out 17.4892 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.92, 112.08 APE9-dihe-in -125.82, 147.19 APE8-dihe-in -85.98, 69.81 APE8-rot-na 32.75 APE67-dihe-in -73.08, -8.74 -50.8, -35.19 APE12-dist-na 21.9009 APE11-dist-na 17.0339 APE10-dist-na 13.4169 APE9-dist-in 7.156 None None None XRAY 2.1 0.181 0.221 A 302.0 300.0 2 30 28 2 [[999, 1268]] 1.0 4d2r Homo sapiens TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW5A P08069 985 1286 1367.0 LGX:60001 Type1 Inactive DFGin 6.6959 16.8864 None -72.74, 167.89 -46.3, 134.17 -70.68, 160.99 291.97, 0.43 38.79, 22.82 out-out out 10.246 Saltbr-out 5.6112 HRD-in -64.28, -52.64 77.7, -10.43 out-out-in SNCooi out-in ActLoopNT-out 16.5593 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.81, 115.11 APE9-dihe-in -124.48, 143.18 APE8-dihe-in -78.32, 63.38 APE8-rot-na 28.02 APE67-dihe-in -71.11, -14.08 -47.07, -38.36 APE12-dist-na 20.2949 APE11-dist-na 16.0987 APE10-dist-na 12.81 APE9-dist-in 7.3623 None None None XRAY 2.14 0.196 0.254 A 307.0 302.0 0 30 30 0 [[999, 1268]] 1.0 3nw5 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW6A P08069 986 1286 1367.0 LGW:60001 Type1 Inactive DFGin 6.3789 16.3293 None -74.88, 163.27 -46.43, 132.32 -66.66, 145.01 298.3, 172.57 60.37, 24.67 out-out out 10.1158 Saltbr-out 5.223 HRD-in -71.12, -48.14 76.3, -15.79 out-out-in SNCooi out-in ActLoopNT-out 18.2237 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.0, 97.67 APE9-dihe-in -118.49, 154.77 APE8-dihe-in -81.27, 69.63 APE8-rot-na 32.94 APE67-dihe-in -72.42, -10.33 -48.22, -40.81 APE12-dist-na 17.1631 APE11-dist-na 16.7091 APE10-dist-na 13.6552 APE9-dist-in 7.1707 None None None XRAY 2.2 0.184 0.253 A 307.0 301.0 0 30 30 0 [[999, 1268]] 1.0 3nw6 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3NW7A P08069 987 1286 1367.0 LGV:60001 Type1 Inactive DFGin 5.9142 15.618 None -79.79, -167.52 -73.83, 143.18 -76.01, 139.22 303.93, 155.83 55.33, 50.19 in-out in 9.9504 Saltbr-out 6.8309 HRD-in -73.07, -47.61 73.35, -7.71 out-out-in SNCooi out-in ActLoopNT-out 15.5758 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.1, 112.82 APE9-dihe-in -110.42, 135.27 APE8-dihe-in -85.88, 69.94 APE8-rot-na 27.32 APE67-dihe-in -72.04, -10.86 -50.71, -38.46 APE12-dist-na 999.0 APE11-dist-na 15.9259 APE10-dist-na 11.7944 APE9-dist-in 7.4664 None None None XRAY 2.11 0.168 0.226 A 307.0 297.0 3 30 27 3 [[999, 1268]] 1.0 3nw7 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXQA P08069 980 1286 1367.0 GD5:62287 Type1 Inactive DFGin 6.1499 16.3952 None -75.24, 161.17 -49.54, 127.03 -61.92, 123.0 295.29, 167.93 87.57, 25.79 out-out out 10.4916 Saltbr-out 7.9238 HRD-in -76.32, -54.31 77.35, -9.89 out-out-in SNCooi out-in ActLoopNT-out 15.0638 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.4, 114.95 APE9-dihe-in -123.96, 146.04 APE8-dihe-in -82.98, 67.94 APE8-rot-na 28.97 APE67-dihe-in -76.69, -10.66 -53.34, -32.39 APE12-dist-na 999.0 APE11-dist-na 16.72 APE10-dist-na 13.0321 APE9-dist-in 7.1477 None None None XRAY 2.3 999.0 0.275 A 308.0 301.0 6 30 27 3 [[999, 1268]] 1.0 5fxq Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXRA P08069 980 1283 1367.0 8LN:62284 Type1 Inactive DFGin 6.3636 16.559 None -71.13, 158.45 -48.25, 129.23 -64.15, 116.2 296.93, 166.85 93.0, 19.74 out-out out 10.5392 Saltbr-out 7.1761 HRD-in -75.83, -55.57 82.75, -12.94 out-out-in SNCooi out-in ActLoopNT-out 15.2577 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.77, 112.68 APE9-dihe-in -129.53, 148.37 APE8-dihe-in -86.54, 69.56 APE8-rot-na 33.95 APE67-dihe-in -74.34, -9.8 -55.93, -31.36 APE12-dist-na 999.0 APE11-dist-na 17.4552 APE10-dist-na 13.7499 APE9-dist-in 7.2423 None None None XRAY 2.4 0.23 0.294 A 308.0 299.0 4 30 27 3 [[999, 1268]] 1.0 5fxr Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3I81A P08069 985 1286 1367.0 EBI:60201 Type1 Inactive DFGin 6.6881 15.7829 None -69.56, 174.65 -71.05, 142.28 -76.41, 136.92 311.88, 126.84 70.68, 14.21 out-out out 10.2163 Saltbr-out 5.6184 HRD-in -62.27, -48.86 72.23, -18.63 out-out-none SNCoon out-none ActLoopNT-out 16.9754 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -54.18 APE9-dihe-in -126.35, 139.61 APE8-dihe-in -88.27, 72.05 APE8-rot-na 24.95 APE67-dihe-in -71.45, -14.34 -46.11, -40.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 15.8738 APE9-dist-in 7.2996 None None None XRAY 2.08 0.221 0.265 A 315.0 296.0 6 30 25 5 [[999, 1268]] 1.0 3i81 Homo sapiens TYR_IGF1R_HUMAN TYR 2.1e-95 324.9 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5FXSA P08069 980 1286 1367.0 OZN:62290 Type1 Inactive DFGin 6.3013 16.4608 None -84.33, 164.5 -49.68, 126.88 -62.59, 125.5 294.84, 163.97 82.66, 11.86 out-none out 10.1503 Saltbr-none 999.0 HRD-in -72.06, -52.4 79.12, -11.09 none-out-in SNCnoi out-in ActLoopNT-out 14.946 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.25, 115.64 APE9-dihe-in -119.16, 145.07 APE8-dihe-in -79.78, 69.43 APE8-rot-na 32.71 APE67-dihe-in -75.57, -9.31 -55.8, -33.39 APE12-dist-na 18.9108 APE11-dist-na 16.7981 APE10-dist-na 13.3529 APE9-dist-in 6.9323 None None None XRAY 1.9 0.183 0.214 A 308.0 307.0 0 30 30 0 [[999, 1268]] 1.0 5fxs Homo sapiens TYR_IGF1R_HUMAN TYR 6.9e-95 323.2 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3D94A P08069 986 1285 1367.0 D94:60001 Type1.5_Front Inactive DFGin 5.7529 12.0902 None -113.77, -141.33 -41.63, 115.12 -104.14, 0.25 54.89, 83.46 -78.61, -17.4 out-out out 11.0351 Saltbr-out 11.2816 HRD-in -72.35, -49.36 78.31, -12.49 out-out-in SNCooi out-in ActLoopNT-out 9.2573 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.21, 135.68 APE9-dihe-in -120.98, 133.2 APE8-dihe-in -80.59, 66.97 APE8-rot-na 24.88 APE67-dihe-in -76.95, -9.87 -55.9, -29.5 APE12-dist-na 12.6456 APE11-dist-na 8.5957 APE10-dist-na 6.4562 APE9-dist-in 7.1111 None None MHO1142 XRAY 2.3 0.2 0.236 A 301.0 289.0 11 30 30 0 [[999, 1268]] 1.0 3d94 Homo sapiens TYR_IGF1R_HUMAN TYR 3.2e-95 324.3 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIAAA P08069 986 1286 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.1834 12.5096 None -115.76, -140.08 -56.69, 128.49 -118.25, -19.27 59.93, 80.29 -40.9, -38.76 out-out out 10.5805 Saltbr-out 8.1365 HRD-in -71.36, -56.99 87.46, -13.56 out-out-none SNCoon out-none ActLoopNT-out 8.9222 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 111.18 APE9-dihe-in -126.65, 126.64 APE8-dihe-in -81.12, 76.62 APE8-rot-na 35.9 APE67-dihe-in -71.26, -20.53 -54.98, -37.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.1722 APE9-dist-in 7.0729 None None None XRAY 3.06 0.193 0.235 AAA 321.0 288.0 13 30 25 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIBBB P08069 986 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2198 12.4468 None -115.29, -140.05 -57.59, 130.35 -119.47, -19.04 57.6, 81.65 -39.33, -40.51 out-out out 10.5812 Saltbr-out 8.1383 HRD-in -71.54, -57.15 87.92, -15.23 out-out-none SNCoon out-none ActLoopNT-out 8.9933 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.31 APE9-dihe-in -126.67, 128.52 APE8-dihe-in -80.09, 76.32 APE8-rot-na 35.62 APE67-dihe-in -70.72, -20.09 -56.2, -36.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.1097 APE9-dist-in 7.0678 None None None XRAY 3.06 0.193 0.235 BBB 321.0 287.0 13 30 25 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYICCC P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.1658 12.5055 None -114.85, -140.89 -57.29, 129.65 -118.38, -19.22 58.71, 80.33 -40.35, -39.19 out-out out 10.5475 Saltbr-out 8.0781 HRD-in -70.97, -56.86 87.86, -15.93 out-out-in SNCooi out-in ActLoopNT-out 8.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -146.69, 116.05 APE9-dihe-in -129.59, 126.27 APE8-dihe-in -80.63, 76.08 APE8-rot-na 36.39 APE67-dihe-in -71.13, -19.68 -54.93, -37.06 APE12-dist-na 999.0 APE11-dist-na 9.6528 APE10-dist-na 6.1837 APE9-dist-in 7.1311 None None None XRAY 3.06 0.193 0.235 CCC 321.0 286.0 13 30 25 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIDDD P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2193 12.4591 None -115.04, -139.19 -57.22, 129.11 -118.66, -19.63 58.67, 81.12 -40.31, -39.48 out-out out 10.6051 Saltbr-out 8.0953 HRD-in -71.24, -57.12 86.84, -13.26 out-out-in SNCooi out-in ActLoopNT-out 8.9353 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.29, 122.24 APE9-dihe-in -125.14, 125.87 APE8-dihe-in -79.9, 75.59 APE8-rot-na 36.0 APE67-dihe-in -70.95, -19.69 -56.73, -36.41 APE12-dist-na 999.0 APE11-dist-na 9.5534 APE10-dist-na 5.9864 APE9-dist-in 7.1246 None None None XRAY 3.06 0.193 0.235 DDD 321.0 287.0 12 30 26 4 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIEEE P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2696 12.4395 None -115.61, -138.87 -56.86, 128.87 -118.49, -19.41 58.83, 81.0 -40.15, -38.87 out-out out 10.5158 Saltbr-out 8.0918 HRD-in -71.39, -56.94 87.82, -14.48 out-out-none SNCoon out-none ActLoopNT-out 8.9511 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 116.42 APE9-dihe-in -125.67, 127.35 APE8-dihe-in -81.15, 76.83 APE8-rot-na 35.52 APE67-dihe-in -70.81, -19.39 -56.95, -36.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.1552 APE9-dist-in 7.1131 None None None XRAY 3.06 0.193 0.235 EEE 321.0 285.0 14 30 24 6 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIFFF P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.3096 12.5061 None -114.84, -139.12 -57.32, 129.09 -119.24, -19.1 58.43, 80.95 -39.6, -40.34 out-out out 10.5617 Saltbr-out 8.089 HRD-in -71.51, -57.69 87.61, -14.16 out-out-in SNCooi out-in ActLoopNT-out 8.9132 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -146.97, 119.39 APE9-dihe-in -127.92, 126.81 APE8-dihe-in -81.17, 76.54 APE8-rot-na 34.85 APE67-dihe-in -70.74, -20.02 -56.2, -36.99 APE12-dist-na 14.2666 APE11-dist-na 9.7045 APE10-dist-na 6.1759 APE9-dist-in 7.0714 None None None XRAY 3.06 0.193 0.235 FFF 321.0 287.0 12 30 27 3 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIGGG P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2153 12.4108 None -115.39, -138.9 -56.85, 128.81 -118.89, -19.11 58.65, 81.01 -40.57, -39.34 out-out out 10.5825 Saltbr-out 8.1508 HRD-in -71.45, -56.87 87.79, -13.89 out-out-none SNCoon out-none ActLoopNT-out 8.956 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.56 APE9-dihe-in -139.88, 129.5 APE8-dihe-in -81.92, 78.52 APE8-rot-na 36.73 APE67-dihe-in -71.48, -19.02 -54.63, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.3133 APE9-dist-in 6.9254 None None None XRAY 3.06 0.193 0.235 GGG 321.0 284.0 15 30 24 6 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIHHH P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.2008 12.4942 None -116.04, -140.1 -57.52, 129.83 -118.81, -19.1 57.82, 80.84 -40.32, -39.43 out-out out 10.6159 Saltbr-out 8.1215 HRD-in -71.69, -57.04 87.53, -14.25 out-out-none SNCoon out-none ActLoopNT-out 8.9588 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.91 APE9-dihe-in -126.66, 127.03 APE8-dihe-in -79.81, 75.92 APE8-rot-na 35.31 APE67-dihe-in -70.25, -19.75 -57.25, -36.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.1541 APE9-dist-in 7.1652 None None None XRAY 3.06 0.193 0.235 HHH 321.0 285.0 14 30 25 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNA P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5233 11.883 None -122.71, -134.04 -48.48, 117.08 -112.65, 5.39 56.52, 89.56 -80.2, -12.63 out-out out 10.1046 Saltbr-out 7.0696 HRD-in -68.72, -44.68 74.42, -15.27 out-out-in SNCooi out-in ActLoopNT-out 9.0816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 129.26 APE9-dihe-in -125.1, 113.12 APE8-dihe-in -76.3, 72.6 APE8-rot-na 31.29 APE67-dihe-in -71.82, -14.27 -59.77, -33.09 APE12-dist-na 12.7798 APE11-dist-na 9.3406 APE10-dist-na 6.0029 APE9-dist-in 7.4125 E1097A,E1099A None None XRAY 2.2 0.195 0.218 A 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNB P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.6676 11.6982 None -120.23, -145.7 -34.99, 114.07 -109.86, 7.02 53.42, 94.67 -86.81, -17.85 out-out out 10.2303 Saltbr-out 7.469 HRD-in -74.79, -42.86 77.21, -19.92 out-out-in SNCooi out-in ActLoopNT-out 8.9724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.8, 127.36 APE9-dihe-in -126.61, 120.91 APE8-dihe-in -82.51, 72.5 APE8-rot-na 31.18 APE67-dihe-in -70.34, -12.61 -56.19, -36.04 APE12-dist-na 12.7105 APE11-dist-na 9.4364 APE10-dist-na 6.0092 APE9-dist-in 7.4127 E1097A,E1099A None None XRAY 2.2 0.195 0.218 B 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNC P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5039 11.8927 None -117.5, -144.25 -35.28, 118.67 -116.54, 5.75 57.58, 87.45 -83.77, -13.7 out-out out 10.2048 Saltbr-out 6.5682 HRD-in -68.11, -52.05 81.72, -11.87 out-out-in SNCooi out-in ActLoopNT-out 8.9794 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.64, 128.06 APE9-dihe-in -121.48, 117.98 APE8-dihe-in -78.81, 67.18 APE8-rot-na 28.39 APE67-dihe-in -73.45, -14.3 -52.08, -33.81 APE12-dist-na 13.0318 APE11-dist-na 9.428 APE10-dist-na 6.062 APE9-dist-in 7.2753 E1097A,E1099A None None XRAY 2.2 0.195 0.218 C 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZND P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5858 11.8119 None -120.23, -138.34 -41.88, 115.18 -111.54, 6.87 52.55, 90.98 -80.5, -21.29 out-out out 10.1558 Saltbr-out 7.0568 HRD-in -75.17, -45.42 77.74, -21.01 out-out-in SNCooi out-in ActLoopNT-out 9.0982 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.35, 128.86 APE9-dihe-in -120.46, 118.5 APE8-dihe-in -79.97, 71.37 APE8-rot-na 32.37 APE67-dihe-in -73.39, -13.02 -52.14, -35.35 APE12-dist-na 13.1787 APE11-dist-na 9.2529 APE10-dist-na 6.0206 APE9-dist-in 7.4528 E1097A,E1099A None None XRAY 2.2 0.195 0.218 D 304.0 304.0 0 30 30 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNE P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5339 11.8843 None -122.97, -133.9 -50.03, 120.11 -115.89, 7.06 56.85, 84.61 -81.92, -13.97 out-out out 10.0903 Saltbr-out 7.0006 HRD-in -71.62, -46.82 77.23, -15.08 out-out-in SNCooi out-in ActLoopNT-out 9.0762 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.35, 128.61 APE9-dihe-in -123.88, 113.86 APE8-dihe-in -76.92, 69.0 APE8-rot-na 31.9 APE67-dihe-in -73.44, -14.93 -54.7, -32.97 APE12-dist-na 12.7562 APE11-dist-na 9.3201 APE10-dist-na 6.0089 APE9-dist-in 7.4173 E1097A,E1099A None None XRAY 2.2 0.195 0.218 E 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNF P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.6688 11.6863 None -119.91, -143.87 -36.57, 117.22 -111.83, 7.84 53.92, 93.37 -86.48, -19.66 out-out out 10.2445 Saltbr-out 7.4948 HRD-in -71.54, -45.74 77.92, -19.28 out-out-in SNCooi out-in ActLoopNT-out 8.9724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.77, 125.58 APE9-dihe-in -123.67, 120.15 APE8-dihe-in -81.16, 71.31 APE8-rot-na 31.34 APE67-dihe-in -70.78, -14.02 -54.99, -34.82 APE12-dist-na 12.6961 APE11-dist-na 9.4311 APE10-dist-na 6.0247 APE9-dist-in 7.4146 E1097A,E1099A None None XRAY 2.2 0.195 0.218 F 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNG P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.4952 11.8883 None -115.22, -143.92 -37.17, 121.14 -119.03, 5.44 57.57, 87.05 -84.31, -13.87 out-out out 10.2119 Saltbr-out 6.5677 HRD-in -69.56, -54.08 84.44, -12.44 out-out-in SNCooi out-in ActLoopNT-out 8.9987 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.44, 128.11 APE9-dihe-in -122.01, 115.9 APE8-dihe-in -78.8, 69.19 APE8-rot-na 29.58 APE67-dihe-in -71.28, -16.87 -55.78, -34.47 APE12-dist-na 13.0183 APE11-dist-na 9.4183 APE10-dist-na 6.0678 APE9-dist-in 7.3121 E1097A,E1099A None None XRAY 2.2 0.195 0.218 G 304.0 296.0 8 30 30 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNH P08069 983 1285 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.5638 11.8399 None -117.51, -139.77 -40.96, 115.52 -113.35, 4.84 52.59, 91.03 -79.05, -20.18 out-out out 10.169 Saltbr-out 7.1318 HRD-in -75.23, -47.04 79.69, -19.55 out-out-in SNCooi out-in ActLoopNT-out 9.1132 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.78, 128.57 APE9-dihe-in -119.04, 118.91 APE8-dihe-in -80.75, 73.24 APE8-rot-na 32.94 APE67-dihe-in -74.0, -12.28 -56.22, -33.69 APE12-dist-na 13.1839 APE11-dist-na 9.2607 APE10-dist-na 6.0308 APE9-dist-in 7.4487 E1097A,E1099A None None XRAY 2.2 0.195 0.218 H 304.0 303.0 0 30 30 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.6413 13.7197 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.8952 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6829 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306.0 282.0 16 30 14 16 [[1023, 1292]] 1.0 1i44 Homo sapiens TYR_INSR_HUMAN TYR 3.4e-96 327.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 1P14A P06213 1005 1310 1382.0 No_ligand No_ligand Inactive DFGin 7.6107 15.3442 None -93.61, -127.04 -78.93, 153.19 -166.81, 155.93 65.2, 94.97 -69.26, 999.0 in-out in 9.2508 Saltbr-out 5.4695 HRD-in -68.39, -55.7 74.95, -11.95 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.41 APE8-rot-na 37.98 APE67-dihe-in -68.35, -7.74 -43.78, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1008S,D1159N None None XRAY 1.9 0.225 0.24 A 306.0 287.0 19 30 11 19 [[1023, 1292]] 1.0 1p14 Homo sapiens TYR_INSR_HUMAN TYR 5e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 4IBMA P06213 1009 1309 1382.0 IR1:61301 Type1 Inactive DFGin 5.6235 15.3135 None -76.0, 163.85 -44.82, 128.63 -69.67, 135.99 297.32, 165.57 60.17, 44.87 out-out out 10.6453 Saltbr-out 7.271 HRD-in -68.74, -46.51 75.22, -15.25 out-out-in SNCooi out-in ActLoopNT-out 15.6653 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 121.44 APE9-dihe-in -109.91, 120.82 APE8-dihe-in -81.27, 70.1 APE8-rot-na 28.73 APE67-dihe-in -71.57, -11.47 -57.01, -32.73 APE12-dist-na 18.7378 APE11-dist-na 15.2744 APE10-dist-na 11.5056 APE9-dist-in 7.3145 K1278N None None XRAY 1.8 0.184 0.218 A 306.0 301.0 0 30 30 0 [[1023, 1292]] 1.0 4ibm Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 4IBMB P06213 1014 1310 1382.0 IR1:61301 Type1 Inactive DFGin 6.943 16.4452 None -69.6, 155.55 -45.67, 125.47 -61.25, 129.45 282.72, 8.49 78.34, 8.83 in-out in 9.4175 Saltbr-out 5.034 HRD-in -66.87, -50.14 74.82, -11.33 out-out-in SNCooi out-in ActLoopNT-out 15.2219 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.04, 122.58 APE9-dihe-in -120.44, 134.35 APE8-dihe-in -81.79, 69.08 APE8-rot-na 32.76 APE67-dihe-in -70.68, -10.48 -58.86, -32.74 APE12-dist-na 19.958 APE11-dist-na 16.3087 APE10-dist-na 12.6646 APE9-dist-in 7.3059 K1278N None None XRAY 1.8 0.184 0.218 B 306.0 294.0 3 30 30 0 [[1023, 1292]] 1.0 4ibm Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 5E1SA P06213 1010 1310 1382.0 5JA:61301 Type1 Inactive DFGin 6.8652 15.0896 None -82.55, -126.51 -82.76, 146.74 -146.5, 173.12 61.91, 96.0 -67.13, 97.4 in-out in 8.8331 Saltbr-out 6.372 HRD-in -66.03, -52.34 70.18, -7.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -78.62, 65.27 APE8-rot-na 31.33 APE67-dihe-in -70.73, -11.27 -48.96, -36.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3247 None None None XRAY 2.264 0.215 0.262 A 308.0 284.0 17 30 13 17 [[1023, 1292]] 1.0 5e1s Homo sapiens TYR_INSR_HUMAN TYR 5.6e-96 326.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 3EKKA P06213 1007 1309 1382.0 GS2:60001 Type1 Inactive DFGin 6.9318 15.2617 None -91.44, -126.11 -77.81, 134.04 -139.23, 999.0 58.35, 102.32 999.0, 999.0 in-out in 9.2869 Saltbr-out 5.3303 HRD-in -69.72, -54.17 78.3, -13.96 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -25.52 APE9-dihe-in -83.53, 136.03 APE8-dihe-in -85.94, 70.21 APE8-rot-na 27.34 APE67-dihe-in -74.98, -12.32 -58.97, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5248 C1008S,D1159N None None XRAY 2.1 0.207 0.26 A 307.0 285.0 18 30 12 18 [[1023, 1292]] 1.0 3ekk Homo sapiens TYR_INSR_HUMAN TYR 5.1e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 3EKNA P06213 1011 1310 1382.0 GS3:60001 Type1 Inactive DFGin 6.2472 13.3535 None -59.53, -41.76 -156.68, -173.98 -81.39, 6.66 55.61, 95.58 69.22, 37.13 in-out in 8.4857 Saltbr-out 4.158 HRD-in -69.98, -55.95 75.05, -7.0 out-out-out SNCooo out-out ActLoopNT-out 9.4799 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.36, -23.41 APE9-dihe-in -94.03, 128.42 APE8-dihe-in -84.32, 117.17 APE8-rot-na 4.91 APE67-dihe-in -79.33, -4.28 -67.04, -22.99 APE12-dist-na 999.0 APE11-dist-na 13.7116 APE10-dist-na 9.2366 APE9-dist-in 4.8268 C1008S,D1159N None None XRAY 2.2 0.214 0.274 A 307.0 297.0 3 30 27 3 [[1023, 1292]] 1.0 3ekn Homo sapiens TYR_INSR_HUMAN TYR 5.1e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 5HHWA P06213 1005 1310 1382.0 60O:1401 Type1.5_Front Inactive DFGin 6.5467 15.218 None -93.96, -126.86 -75.33, 119.05 -115.08, 17.9 55.03, 94.29 -68.54, 168.98 in-out in 9.6442 Saltbr-out 6.2026 HRD-in -63.14, -55.1 75.15, -13.24 out-out-in SNCooi out-in ActLoopNT-out 12.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.8, 124.07 APE9-dihe-in -122.61, 132.0 APE8-dihe-in -80.76, 65.66 APE8-rot-na 27.91 APE67-dihe-in -68.74, -10.86 -50.91, -39.07 APE12-dist-na 13.7099 APE11-dist-na 10.9449 APE10-dist-na 9.756 APE9-dist-in 7.5063 C1008S,D1159N None None XRAY 1.79 0.172 0.198 A 307.0 306.0 0 30 30 0 [[1023, 1292]] 1.0 5hhw Homo sapiens TYR_INSR_HUMAN TYR 5.5e-96 326.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR ITK ITK_HUMAN 3MIYA Q08881 357 619 620.0 B49:60001 Type1 Inactive DFGin 4.4986 14.3272 None -118.72, 169.24 51.5, 47.57 -103.74, 999.0 53.54, 86.2 999.0, 999.0 in-out in 9.8276 Saltbr-out 5.0446 HRD-in -71.62, -53.3 80.88, -14.93 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.04 APE8-rot-na 334.29 APE67-dihe-in -65.24, -21.92 -59.14, -28.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C477S,E614A,E617A None None XRAY 1.67 0.208 0.234 A 266.0 237.0 26 29 10 19 [[363, 614]] 1.0 3miy Homo sapiens TYR_ITK_HUMAN TYR 5e-93 317.1 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3MJ1A Q08881 357 615 620.0 614:60001 Type1 Inactive DFGin 5.9676 13.3428 None -126.6, 166.8 59.09, 29.18 -76.15, 999.0 48.51, 86.56 999.0, 999.0 out-out out 13.5229 Saltbr-out 12.0653 HRD-in -66.18, -54.69 85.37, -19.01 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.56 APE8-rot-na 26.94 APE67-dihe-in -66.28, -13.64 -60.47, -30.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C477S,E614A,E617A None None XRAY 1.72 0.238 0.264 A 266.0 226.0 33 29 10 19 [[363, 614]] 1.0 3mj1 Homo sapiens TYR_ITK_HUMAN TYR 5e-93 317.1 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PQNA Q08881 357 615 620.0 2W6:701 Type1 Inactive DFGin 5.2901 14.7453 None -102.53, 173.37 -57.89, 164.97 -164.74, 161.08 47.42, 91.82 137.98, 999.0 in-out in 9.105 Saltbr-out 4.4161 HRD-in -70.76, -53.31 78.34, -16.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.94 APE8-dihe-in -78.94, 66.59 APE8-rot-na 37.6 APE67-dihe-in -61.43, -23.35 -57.61, -35.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.9577 C477S,E614A,E617A None None XRAY 1.71 0.161 0.202 A 266.0 240.0 19 29 12 17 [[363, 614]] 1.0 4pqn Homo sapiens TYR_ITK_HUMAN TYR 5e-93 317.1 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4MF0B Q08881 357 619 620.0 29Z:701 Type1 Inactive DFGin 6.8221 14.6295 None -147.79, -179.99 59.06, 76.1 -152.71, 999.0 51.7, 89.28 999.0, 999.0 out-out out 13.6042 Saltbr-out 14.5985 HRD-in -57.08, -45.93 79.95, -24.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.72 APE8-rot-na 30.57 APE67-dihe-in -60.16, -25.12 -59.46, -35.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y512E None None XRAY 2.67 0.215 0.268 B 266.0 237.0 26 29 10 19 [[363, 614]] 1.0 4mf0 Homo sapiens TYR_ITK_HUMAN TYR 2.1e-92 315.0 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PPCA Q08881 357 619 620.0 2VW:60701 Type1 Inactive DFGin 7.2293 13.3321 None -135.89, 168.01 69.21, 69.58 -147.47, 999.0 49.13, 86.55 999.0, 999.0 out-out out 13.4252 Saltbr-out 11.899 HRD-in -71.06, -46.31 73.14, -9.54 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.1 APE8-rot-na 25.52 APE67-dihe-in -66.61, -24.14 -69.06, -21.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y512E None None XRAY 2.95 0.215 0.257 A 266.0 232.0 31 29 10 19 [[363, 614]] 1.0 4ppc Homo sapiens TYR_ITK_HUMAN TYR 2.1e-92 315.0 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4PPCB Q08881 357 619 620.0 2VW:60701 Type1 Inactive DFGin 6.5864 13.7199 None -127.88, 164.09 63.12, 56.47 -117.01, 999.0 50.83, 90.79 999.0, 999.0 out-out out 13.4584 Saltbr-out 10.2014 HRD-in -62.38, -51.21 79.16, -15.21 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.83 APE8-rot-na 22.06 APE67-dihe-in -58.68, -39.7 -66.95, -19.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y512E None None XRAY 2.95 0.215 0.257 B 266.0 230.0 33 29 10 19 [[363, 614]] 1.0 4ppc Homo sapiens TYR_ITK_HUMAN TYR 2.1e-92 315.0 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3QGWB Q08881 358 616 620.0 L7A:1 Type1 Inactive DFGin 5.1023 13.9528 None -132.64, -179.26 57.93, 42.12 -120.25, 999.0 60.69, 93.21 999.0, 999.0 in-out in 9.0896 Saltbr-out 5.424 HRD-in -75.97, -46.45 75.23, -6.09 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.51 APE8-rot-na 37.77 APE67-dihe-in -72.69, -9.67 -54.86, -23.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.245 0.32 B 286.0 240.0 19 29 10 19 [[363, 614]] 1.0 3qgw Homo sapiens TYR_ITK_HUMAN TYR 1.3e-92 315.7 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SM2B Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.378 13.3785 None -126.46, -161.15 38.96, 42.72 -115.58, 999.0 63.86, 78.79 999.0, 999.0 out-out out 11.099 Saltbr-out 6.8051 HRD-out -89.1, 89.71 -64.14, 17.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.78 APE8-rot-na 24.5 APE67-dihe-in -53.23, -18.63 -53.68, -42.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 B 264.0 241.0 19 29 10 19 [[363, 614]] 1.0 1sm2 Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUB Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.3215 13.3612 None -135.24, -161.39 47.41, 33.44 -112.08, 999.0 66.07, 77.87 999.0, 999.0 out-out out 11.1179 Saltbr-out 7.4836 HRD-out -85.26, 96.7 -69.16, 21.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.67 APE8-rot-na 31.48 APE67-dihe-in -68.53, -31.16 -49.5, -27.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 B 264.0 241.0 19 29 10 19 [[363, 614]] 1.0 1snu Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3V5JB Q08881 357 620 620.0 0F2:60701 Type1 Inactive DFGin 4.4328 14.4384 None -124.07, 161.2 59.09, 58.27 -105.58, 999.0 45.39, 90.64 999.0, 999.0 out-none out 10.3469 Saltbr-none 999.0 HRD-out -89.74, 97.95 -71.99, -8.9 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 8.88 APE8-rot-na 21.22 APE67-dihe-in -67.81, -24.63 -68.6, -25.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.246 0.27 B 266.0 239.0 25 29 10 19 [[363, 614]] 1.0 3v5j Homo sapiens TYR_ITK_HUMAN TYR 9.4e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR JAK1-1 JAK1_HUMAN 4L01A P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.7918 12.0795 None -73.75, -179.09 -73.9, 162.14 -73.89, -15.61 344.71, 28.42 67.96, -153.13 in-na in 9.5433 Saltbr-na 999.0 HRD-in -87.9, -71.89 94.16, -0.24 na-out-out SNCaoo out-out ActLoopNT-out 7.9539 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.86, -39.57 APE9-dihe-out -58.05, -29.58 APE8-dihe-out -81.67, -7.08 APE8-rot-na 199.85 APE67-dihe-out -101.51, 19.28 -61.73, 134.72 APE12-dist-na 9.3413 APE11-dist-na 11.7555 APE10-dist-na 15.957 APE9-dist-out 11.1256 V658F None None XRAY 1.9 0.204 0.233 A 304.0 274.0 12 24 24 0 [[583, 847], [875, 1151]] 2.0 4l01 Homo sapiens TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L01B P23458 565 849 1154.0 No_ligand No_ligand Pseudo DFGin 6.8232 11.8723 None -76.74, -176.42 -72.49, 166.45 -77.53, -11.38 359.0, 15.1 69.24, -153.25 in-na in 8.8926 Saltbr-na 999.0 HRD-in -86.59, -73.54 93.9, -0.47 na-out-out SNCaoo out-out ActLoopNT-out 8.016 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.69, -39.64 APE9-dihe-out -57.55, -28.87 APE8-dihe-out -85.94, -3.15 APE8-rot-na 200.27 APE67-dihe-out -99.61, 21.88 -63.69, 136.29 APE12-dist-na 9.2987 APE11-dist-na 11.6951 APE10-dist-na 15.8459 APE9-dist-out 11.03 V658F None None XRAY 1.9 0.204 0.233 B 304.0 274.0 11 24 24 0 [[583, 847], [875, 1151]] 2.0 4l01 Homo sapiens TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00A P23458 564 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.9117 11.988 None -76.07, -177.45 -75.3, 165.45 -78.74, -7.85 349.06, 24.36 63.89, -153.3 in-na in 9.5606 Saltbr-na 999.0 HRD-in -93.36, -71.42 93.51, 0.78 na-out-out SNCaoo out-out ActLoopNT-out 7.9607 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.21, -40.39 APE9-dihe-out -55.79, -30.01 APE8-dihe-out -85.56, 0.43 APE8-rot-na 187.12 APE67-dihe-out -101.03, 20.07 -69.52, 138.76 APE12-dist-na 9.4963 APE11-dist-na 11.8801 APE10-dist-na 16.1265 APE9-dist-out 11.1634 None None None XRAY 1.8 0.171 0.203 A 304.0 277.0 10 24 24 0 [[583, 847], [875, 1151]] 2.0 4l00 Homo sapiens TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00B P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.8723 11.9738 None -78.39, -173.09 -77.68, 164.49 -74.46, -8.56 347.77, 22.41 63.58, -153.63 in-na in 8.9735 Saltbr-na 999.0 HRD-in -90.15, -72.75 94.75, 3.66 na-out-out SNCaoo out-out ActLoopNT-out 7.929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.66, -39.95 APE9-dihe-out -56.84, -31.4 APE8-dihe-out -81.07, -3.08 APE8-rot-na 200.04 APE67-dihe-out -104.62, 20.8 -63.46, 134.32 APE12-dist-na 9.3701 APE11-dist-na 11.8496 APE10-dist-na 15.9108 APE9-dist-out 11.081 None None None XRAY 1.8 0.171 0.203 B 304.0 278.0 8 24 24 0 [[583, 847], [875, 1151]] 2.0 4l00 Homo sapiens TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.6682 13.3858 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.6814 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.0371 APE11-dist-na 11.7 APE10-dist-na 16.2781 APE9-dist-out 12.3723 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5i4n Homo sapiens TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.7656 13.3758 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.7821 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.5367 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.4734 APE10-dist-na 16.0369 APE9-dist-out 12.0279 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvr Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.4109 13.5312 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.3574 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.0941 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.9123 APE11-dist-na 11.4873 APE10-dist-na 16.0746 APE9-dist-out 12.3782 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvq Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.5983 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.3998 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.4736 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.9203 APE11-dist-na 11.8594 APE10-dist-na 16.3524 APE9-dist-out 12.5304 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289.0 270.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.6459 13.5394 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.1784 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.7296 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.8478 APE11-dist-na 11.8372 APE10-dist-na 16.5999 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289.0 269.0 6 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4B O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.0162 13.6285 None -84.33, -175.92 -78.92, 160.47 -67.97, -29.51 344.52, 29.43 84.02, -159.01 out-na out 10.5477 Saltbr-na 999.0 HRD-in -80.56, -60.88 93.85, -0.35 na-out-out SNCaoo out-out ActLoopNT-out 9.2529 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.77, -41.18 APE9-dihe-out -60.58, -30.76 APE8-dihe-out -85.29, 2.29 APE8-rot-na 288.75 APE67-dihe-out -100.46, 22.84 -59.03, 138.57 APE12-dist-na 9.6698 APE11-dist-na 11.3976 APE10-dist-na 15.9347 APE9-dist-out 12.6673 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 B 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba4 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVPA O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.8931 13.0904 None -91.01, 179.45 -75.79, 153.56 -78.3, -11.29 26.93, 143.21 73.75, -158.65 out-na out 13.1657 Saltbr-na 999.0 HRD-in -83.21, -62.84 93.75, -4.6 na-out-out SNCaoo out-out ActLoopNT-out 9.629 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.0, -41.33 APE9-dihe-out -58.79, -30.31 APE8-dihe-out -86.85, 3.46 APE8-rot-na 297.22 APE67-dihe-out -102.61, 25.98 -63.62, 134.65 APE12-dist-na 9.8827 APE11-dist-na 11.6748 APE10-dist-na 16.1441 APE9-dist-out 12.5432 W659A,W777A,F794H None None XRAY 2.01 0.181 0.212 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvp Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C09A O60674 538 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.0525 13.2527 None -86.22, -176.26 -73.29, 161.33 -72.41, -30.09 344.35, 29.81 80.16, -162.74 out-na out 11.184 Saltbr-na 999.0 HRD-in -80.44, -66.09 97.2, -4.64 na-out-out SNCaoo out-out ActLoopNT-out 9.0791 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.51, -34.73 APE9-dihe-out -64.77, -31.42 APE8-dihe-out -84.71, 1.64 APE8-rot-na 292.35 APE67-dihe-out -99.58, 28.31 -60.08, 137.86 APE12-dist-na 9.8638 APE11-dist-na 11.5573 APE10-dist-na 16.1216 APE9-dist-out 12.4835 I559F,W659A,W777A,F794H None None XRAY 1.9 0.223 0.257 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c09 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.3e-63 220.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CA O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.9293 13.2972 None -92.88, -174.23 -74.55, 160.0 -77.81, -9.76 27.51, 143.79 70.13, -167.0 in-na in 9.4623 Saltbr-na 999.0 HRD-in -89.47, -61.45 91.27, -4.79 na-out-out SNCaoo out-out ActLoopNT-out 9.753 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.76, -39.79 APE9-dihe-out -61.91, -29.13 APE8-dihe-out -80.12, 0.2 APE8-rot-na 289.19 APE67-dihe-out -101.75, 22.48 -69.62, 136.72 APE12-dist-na 9.7666 APE11-dist-na 11.5665 APE10-dist-na 16.1545 APE9-dist-out 12.7021 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 A 272.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6g3c Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CB O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.9902 13.415 None -91.77, -175.11 -73.45, 159.45 -76.52, -11.86 28.49, 143.52 73.41, -164.04 in-na in 9.643 Saltbr-na 999.0 HRD-in -89.94, -61.82 90.1, -3.95 na-out-out SNCaoo out-out ActLoopNT-out 9.6929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.88, -39.41 APE9-dihe-out -62.88, -28.18 APE8-dihe-out -81.21, 1.24 APE8-rot-na 288.18 APE67-dihe-out -102.69, 23.29 -70.43, 136.03 APE12-dist-na 9.7694 APE11-dist-na 11.5802 APE10-dist-na 16.1381 APE9-dist-out 12.6902 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 B 272.0 268.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6g3c Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IA O60674 536 808 1132.0 35R:901 Type1 Pseudo DFGin 6.5522 13.6514 None -85.6, -168.64 -71.02, 159.25 -67.8, -19.61 341.93, 32.5 72.61, -145.53 in-na in 9.6393 Saltbr-na 999.0 HRD-in -88.15, -70.56 100.36, -8.76 na-out-out SNCaoo out-out ActLoopNT-out 9.7002 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.19, -30.63 APE9-dihe-out -73.76, -13.56 APE8-dihe-out -89.52, 2.58 APE8-rot-na 300.29 APE67-dihe-out -99.98, 28.53 -66.76, 135.82 APE12-dist-na 10.5196 APE11-dist-na 11.5137 APE10-dist-na 16.3152 APE9-dist-out 13.0189 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 A 273.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IB O60674 537 808 1132.0 35R:901 Type1 Pseudo DFGin 6.7449 13.508 None -83.97, -172.62 -69.78, 158.02 -65.46, -20.62 341.26, 32.34 71.79, -145.54 in-na in 9.4363 Saltbr-na 999.0 HRD-in -84.58, -69.97 97.0, -6.55 na-out-out SNCaoo out-out ActLoopNT-out 9.4489 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.97, -30.79 APE9-dihe-out -72.59, -17.09 APE8-dihe-out -89.77, 2.61 APE8-rot-na 301.92 APE67-dihe-out -99.31, 27.86 -67.19, 135.78 APE12-dist-na 10.5863 APE11-dist-na 11.8904 APE10-dist-na 16.6501 APE9-dist-out 12.8955 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 B 273.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8NA O60674 536 809 1132.0 AQG:904 Type1 Pseudo DFGin 6.9922 13.5588 None -86.6, 176.83 -72.07, 163.0 -83.55, -11.71 8.83, 7.64 73.11, -166.45 out-na out 10.2232 Saltbr-na 999.0 HRD-in -77.47, -60.54 92.78, -1.1 na-out-out SNCaoo out-out ActLoopNT-out 9.2549 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.27, -38.06 APE9-dihe-out -61.66, -30.26 APE8-dihe-out -80.2, 3.05 APE8-rot-na 289.81 APE67-dihe-out -99.17, 33.25 -63.6, 138.44 APE12-dist-na 9.5537 APE11-dist-na 11.4484 APE10-dist-na 15.9705 APE9-dist-out 12.4531 W659A,W777A,F794H None None XRAY 2.0 0.211 0.255 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8n Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.821 13.2982 None -86.5, 168.2 -72.83, 159.81 -77.39, -5.69 29.32, 142.66 68.85, -165.5 in-na in 9.6368 Saltbr-na 999.0 HRD-in -85.53, -63.36 91.05, -0.77 na-out-out SNCaoo out-out ActLoopNT-out 9.5857 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -40.18 APE9-dihe-out -60.78, -27.05 APE8-dihe-out -85.5, 2.2 APE8-rot-na 288.85 APE67-dihe-out -105.88, 26.49 -64.53, 136.9 APE12-dist-na 9.8393 APE11-dist-na 11.5435 APE10-dist-na 16.1353 APE9-dist-out 12.651 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8u Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UB O60674 538 809 1132.0 T7I:903 Type1 Pseudo DFGin 7.6842 13.3671 None -85.95, 172.23 -73.23, 159.57 -79.19, -7.74 28.18, 144.77 71.86, -165.96 in-na in 9.8706 Saltbr-na 999.0 HRD-in -85.44, -62.47 91.56, -1.37 na-out-out SNCaoo out-out ActLoopNT-out 9.4049 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.42, -39.8 APE9-dihe-out -61.59, -26.48 APE8-dihe-out -85.69, -0.76 APE8-rot-na 289.8 APE67-dihe-out -104.95, 23.87 -61.36, 134.02 APE12-dist-na 9.8928 APE11-dist-na 11.4874 APE10-dist-na 16.1064 APE9-dist-out 12.5476 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 B 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8u Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA2A O60674 536 810 1132.0 Q9X:907 Type1 Pseudo DFGin 5.7073 13.2724 None -74.82, 174.75 -67.11, 161.11 -77.71, -21.19 340.67, 34.41 73.6, -166.64 out-na out 11.6572 Saltbr-na 999.0 HRD-in -83.09, -59.59 87.04, -0.99 na-out-out SNCaoo out-out ActLoopNT-out 8.9491 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.59, -40.16 APE9-dihe-out -57.17, -31.99 APE8-dihe-out -85.57, 4.75 APE8-rot-na 288.77 APE67-dihe-out -102.79, 29.41 -64.21, 136.1 APE12-dist-na 9.7351 APE11-dist-na 11.4317 APE10-dist-na 16.0182 APE9-dist-out 12.2832 W659A,W777A,F794H None None XRAY 1.5 0.178 0.204 A 289.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba2 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4A O60674 536 809 1132.0 Q8U:901 Type1 Pseudo DFGin 7.9438 13.4117 None -71.69, 172.79 -67.86, 161.07 -79.48, -19.97 29.54, 146.52 81.3, -166.68 in-na in 9.7879 Saltbr-na 999.0 HRD-in -74.34, -63.4 91.62, 2.89 na-out-out SNCaoo out-out ActLoopNT-out 8.5896 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.98, -39.28 APE9-dihe-out -56.91, -30.54 APE8-dihe-out -86.08, -1.03 APE8-rot-na 290.49 APE67-dihe-out -99.32, 21.83 -60.56, 137.6 APE12-dist-na 9.9255 APE11-dist-na 11.6473 APE10-dist-na 16.1443 APE9-dist-out 12.3271 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba4 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WA O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.915 13.7962 None -91.54, 171.73 -67.57, 155.24 -69.34, -22.33 351.29, 21.05 78.83, -168.1 out-na out 10.1693 Saltbr-na 999.0 HRD-in -84.02, -62.23 90.48, 0.05 na-out-out SNCaoo out-out ActLoopNT-out 9.7232 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.04, -35.76 APE9-dihe-out -66.77, -25.16 APE8-dihe-out -85.21, 3.67 APE8-rot-na 284.34 APE67-dihe-out -100.56, 25.85 -66.38, 135.35 APE12-dist-na 9.6893 APE11-dist-na 11.4731 APE10-dist-na 16.0322 APE9-dist-out 12.6531 None None None XRAY 1.83 0.208 0.238 A 275.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7f7w Homo sapiens TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WB O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.9033 13.6869 None -84.95, 175.07 -74.42, 156.63 -70.62, -23.21 351.87, 21.25 77.0, -167.15 out-na out 10.2517 Saltbr-na 999.0 HRD-in -79.03, -66.0 95.6, -1.12 na-out-out SNCaoo out-out ActLoopNT-out 9.4951 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.33, -37.68 APE9-dihe-out -69.53, -21.97 APE8-dihe-out -87.12, 4.19 APE8-rot-na 285.11 APE67-dihe-out -99.09, 24.95 -67.63, 136.04 APE12-dist-na 9.7044 APE11-dist-na 11.4907 APE10-dist-na 16.0173 APE9-dist-out 12.671 None None None XRAY 1.83 0.208 0.238 B 275.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7f7w Homo sapiens TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B99A O60674 536 809 1132.0 SKE:1003 Type1 Pseudo DFGin 5.8292 13.1897 None -69.78, 174.05 -70.57, 162.32 -72.88, -28.63 342.75, 30.69 79.14, -167.36 out-na out 11.6139 Saltbr-na 999.0 HRD-in -83.46, -62.07 90.64, -3.52 na-out-out SNCaoo out-out ActLoopNT-out 8.8443 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.87, -40.42 APE9-dihe-out -54.81, -33.54 APE8-dihe-out -85.07, 3.29 APE8-rot-na 283.44 APE67-dihe-out -103.17, 28.18 -66.12, 134.93 APE12-dist-na 9.7642 APE11-dist-na 11.3667 APE10-dist-na 15.959 APE9-dist-out 12.1602 W777A,F794H None None XRAY 1.6 0.19 0.211 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b99 Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.7694 13.2256 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.7256 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.9495 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.6132 APE11-dist-na 11.3156 APE10-dist-na 15.8543 APE9-dist-out 12.1058 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9e Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BABA O60674 536 809 1132.0 Q8N:908 Type1 Pseudo DFGin 5.7827 13.347 None -82.44, 178.74 -69.43, 159.24 -76.71, -21.64 341.13, 33.08 75.74, -169.92 out-na out 11.796 Saltbr-na 999.0 HRD-in -85.23, -57.58 89.38, -3.23 na-out-out SNCaoo out-out ActLoopNT-out 9.0793 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.14, -39.62 APE9-dihe-out -58.1, -35.37 APE8-dihe-out -80.74, 3.58 APE8-rot-na 288.39 APE67-dihe-out -100.89, 27.42 -62.52, 138.56 APE12-dist-na 9.8808 APE11-dist-na 11.4994 APE10-dist-na 16.1225 APE9-dist-out 12.5374 W777A,F794H None None XRAY 1.55 0.176 0.203 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8bab Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BAKA O60674 536 809 1132.0 AD5:906 Type1 Pseudo DFGin 5.9 13.4848 None -79.74, 176.09 -70.26, 155.83 -67.8, -33.14 338.52, 35.12 82.51, -172.71 out-na out 11.7434 Saltbr-na 999.0 HRD-in -82.49, -60.1 89.16, -0.66 na-out-out SNCaoo out-out ActLoopNT-out 9.0218 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.79, -43.24 APE9-dihe-out -56.17, -32.1 APE8-dihe-out -84.4, 4.03 APE8-rot-na 284.51 APE67-dihe-out -100.67, 27.47 -64.95, 137.17 APE12-dist-na 9.8834 APE11-dist-na 11.5875 APE10-dist-na 16.1406 APE9-dist-out 12.6164 W777A,F794H None None XRAY 1.65 0.185 0.207 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8bak Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.565 13.3537 None -83.75, 166.81 -71.24, 158.41 -74.12, -10.51 25.45, 142.36 78.43, -168.66 in-na in 9.5594 Saltbr-na 999.0 HRD-in -83.22, -65.0 92.23, 1.81 na-out-out SNCaoo out-out ActLoopNT-out 9.6006 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -71.23, -34.89 APE9-dihe-out -65.21, -28.5 APE8-dihe-out -84.82, 8.34 APE8-rot-na 293.37 APE67-dihe-out -106.96, 23.1 -69.15, 131.91 APE12-dist-na 9.8924 APE11-dist-na 11.6237 APE10-dist-na 16.1468 APE9-dist-out 12.5708 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c0a Homo sapiens TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AB O60674 536 808 1132.0 T7I:902 Type1 Pseudo DFGin 7.4852 13.3983 None -84.77, 172.51 -72.53, 156.76 -75.35, -8.78 26.64, 140.87 71.28, -164.53 in-na in 9.8045 Saltbr-na 999.0 HRD-in -81.32, -65.94 88.05, 6.45 na-out-out SNCaoo out-out ActLoopNT-out 9.4136 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.73, -37.68 APE9-dihe-out -64.41, -27.87 APE8-dihe-out -85.03, 1.77 APE8-rot-na 284.08 APE67-dihe-out -105.43, 24.1 -65.54, 134.17 APE12-dist-na 9.7722 APE11-dist-na 11.4589 APE10-dist-na 16.0887 APE9-dist-out 12.4962 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 B 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c0a Homo sapiens TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIJA O60674 536 809 1132.0 AQG:901 Type1 Pseudo DFGin 7.8557 13.5657 None -91.12, 177.94 -71.51, 155.95 -79.01, -8.25 29.98, 143.91 73.76, -166.11 in-na in 9.9173 Saltbr-na 999.0 HRD-in -72.47, -68.91 101.27, -5.66 na-out-out SNCaoo out-out ActLoopNT-out 9.3062 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.59, -26.98 APE9-dihe-out -64.74, -27.71 APE8-dihe-out -87.29, 3.84 APE8-rot-na 291.39 APE67-dihe-out -100.01, 30.88 -65.27, 134.93 APE12-dist-na 9.6175 APE11-dist-na 11.4946 APE10-dist-na 15.9937 APE9-dist-out 12.5098 W659A,W777A,F794H None None XRAY 2.04 0.209 0.231 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wij Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIKB O60674 536 809 1132.0 584:901 Type1 Pseudo DFGin 8.1996 13.4773 None -86.83, -177.1 -74.98, 154.5 -75.92, -8.34 30.63, 142.46 77.38, -163.2 out-na out 10.0153 Saltbr-na 999.0 HRD-in -75.13, -71.22 102.4, -1.09 na-out-out SNCaoo out-out ActLoopNT-out 9.4124 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.94, -26.86 APE9-dihe-out -70.71, -25.41 APE8-dihe-out -85.62, 4.24 APE8-rot-na 286.3 APE67-dihe-out -97.88, 28.27 -66.61, 137.0 APE12-dist-na 9.6629 APE11-dist-na 11.4185 APE10-dist-na 16.0555 APE9-dist-out 12.5943 W659A,W777A,F794H None None XRAY 2.6 0.211 0.251 B 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wik Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WILA O60674 536 809 1132.0 YDJ:901 Type1 Pseudo DFGin 7.5307 13.7171 None -83.87, 163.34 -72.42, 163.18 -87.02, -3.44 24.44, 145.33 75.07, -167.72 out-na out 10.4597 Saltbr-na 999.0 HRD-in -86.92, -55.39 94.23, -3.93 na-out-out SNCaoo out-out ActLoopNT-out 9.6652 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.97, -30.77 APE9-dihe-out -75.41, -19.35 APE8-dihe-out -84.61, 10.2 APE8-rot-na 287.01 APE67-dihe-out -99.8, 25.99 -70.86, 137.89 APE12-dist-na 9.547 APE11-dist-na 11.4807 APE10-dist-na 16.0397 APE9-dist-out 12.6921 W659A,W777A,F794H None None XRAY 2.2 0.201 0.231 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wil Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIMA O60674 536 809 1132.0 35R:901 Type1 Pseudo DFGin 7.7523 13.5845 None -93.28, 176.5 -38.24, 151.14 -78.63, -21.68 29.2, 149.11 81.15, -169.97 out-na out 10.5675 Saltbr-na 999.0 HRD-in -83.09, -66.39 96.8, 0.86 na-out-out SNCaoo out-out ActLoopNT-out 9.8496 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -105.18, -10.47 APE9-dihe-out -83.98, -20.52 APE8-dihe-out -80.31, 9.26 APE8-rot-na 299.8 APE67-dihe-out -97.29, 28.98 -67.31, 132.23 APE12-dist-na 9.8326 APE11-dist-na 11.5419 APE10-dist-na 15.898 APE9-dist-out 12.8889 W659A,W777A,F794H None None XRAY 2.55 0.211 0.258 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wim Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WINA O60674 536 809 1132.0 SKE:901 Type1 Pseudo DFGin 7.2805 13.7901 None -75.17, 174.41 -74.13, 155.6 -73.15, -17.87 26.75, 146.64 81.14, -159.91 out-na out 10.8153 Saltbr-na 999.0 HRD-in -80.84, -67.43 99.6, -2.16 na-out-out SNCaoo out-out ActLoopNT-out 9.5544 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -35.02 APE9-dihe-out -59.2, -25.51 APE8-dihe-out -88.93, -4.07 APE8-rot-na 287.0 APE67-dihe-out -96.98, 26.41 -56.71, 138.03 APE12-dist-na 9.5649 APE11-dist-na 11.6365 APE10-dist-na 16.0252 APE9-dist-out 12.3691 W659A,W777A,F794H None None XRAY 2.38 0.221 0.244 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5win Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5USZA O60674 537 808 1132.0 SKE:901 Type1 Pseudo DFGin 7.1469 13.1661 None -89.06, 179.4 -74.28, 155.49 -78.9, -12.42 30.8, 143.13 73.21, -171.41 in-na in 9.3491 Saltbr-na 999.0 HRD-in -84.39, -62.72 100.4, -8.06 na-out-out SNCaoo out-out ActLoopNT-out 9.8029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.11, -40.08 APE9-dihe-out -63.02, -23.47 APE8-dihe-out -87.07, 3.62 APE8-rot-na 290.38 APE67-dihe-out -103.08, 29.45 -63.02, 136.82 APE12-dist-na 10.1185 APE11-dist-na 11.6069 APE10-dist-na 16.2335 APE9-dist-out 12.8894 W659A,W777A,F794H None None XRAY 2.103 0.174 0.224 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5usz Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT0A O60674 537 808 1132.0 35R:903 Type1 Pseudo DFGin 7.594 13.5715 None -93.9, 174.39 -69.93, 155.11 -74.3, -13.06 28.06, 143.5 77.21, -173.63 in-na in 9.9387 Saltbr-na 999.0 HRD-in -83.57, -61.23 99.02, -12.98 na-out-out SNCaoo out-out ActLoopNT-out 9.9661 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.47, -40.74 APE9-dihe-out -59.34, -26.03 APE8-dihe-out -86.35, 4.34 APE8-rot-na 287.5 APE67-dihe-out -101.06, 28.12 -64.23, 136.97 APE12-dist-na 10.0051 APE11-dist-na 11.4779 APE10-dist-na 16.1348 APE9-dist-out 12.9322 W659A,W777A,F794H None None XRAY 2.102 0.171 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT1A O60674 537 808 1132.0 7DZ:905 Type1 Pseudo DFGin 7.3785 13.4637 None -94.09, -179.69 -75.66, 158.87 -74.76, -6.96 27.15, 144.11 69.28, -174.72 in-na in 9.6956 Saltbr-na 999.0 HRD-in -82.87, -62.64 95.48, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8118 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -38.46 APE9-dihe-out -62.2, -22.99 APE8-dihe-out -88.42, 4.71 APE8-rot-na 293.57 APE67-dihe-out -104.03, 27.01 -63.75, 135.14 APE12-dist-na 10.1099 APE11-dist-na 11.6437 APE10-dist-na 16.2104 APE9-dist-out 12.8829 W659A,W777A,F794H None None XRAY 1.95 0.165 0.202 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut1 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT2A O60674 536 808 1132.0 3YT:903 Type1 Pseudo DFGin 7.1266 13.3116 None -90.0, 179.18 -75.04, 157.7 -78.17, -8.03 29.61, 139.64 71.77, -178.13 in-na in 9.4878 Saltbr-na 999.0 HRD-in -87.63, -60.17 95.16, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.8702 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.9, -38.59 APE9-dihe-out -61.51, -24.95 APE8-dihe-out -88.74, 4.33 APE8-rot-na 288.64 APE67-dihe-out -101.61, 25.26 -63.02, 138.09 APE12-dist-na 10.0143 APE11-dist-na 11.5548 APE10-dist-na 16.1573 APE9-dist-out 12.8792 W659A,W777A,F794H None None XRAY 1.75 0.163 0.201 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut2 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT3A O60674 537 808 1132.0 IK1:901 Type1 Pseudo DFGin 7.2677 13.4017 None -92.6, 177.07 -71.65, 158.85 -79.65, -10.03 26.8, 143.01 73.38, -177.18 in-na in 9.6825 Saltbr-na 999.0 HRD-in -85.94, -61.54 97.51, -8.49 na-out-out SNCaoo out-out ActLoopNT-out 10.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.63, -39.44 APE9-dihe-out -66.05, -19.54 APE8-dihe-out -89.06, 2.9 APE8-rot-na 290.51 APE67-dihe-out -104.18, 27.32 -64.34, 136.22 APE12-dist-na 9.9898 APE11-dist-na 11.5779 APE10-dist-na 16.1923 APE9-dist-out 12.9958 W659A,W777A,F794H None None XRAY 1.501 0.156 0.17 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut3 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT4A O60674 537 809 1132.0 DQX:901 Type1 Pseudo DFGin 7.4596 13.2847 None -91.51, 174.25 -72.2, 155.17 -81.53, -6.98 30.25, 144.04 71.5, -173.67 in-na in 9.7389 Saltbr-na 999.0 HRD-in -82.44, -62.81 97.57, -6.96 na-out-out SNCaoo out-out ActLoopNT-out 9.5951 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.04, -37.57 APE9-dihe-out -62.17, -24.8 APE8-dihe-out -89.02, 2.73 APE8-rot-na 291.23 APE67-dihe-out -103.04, 31.05 -61.52, 137.36 APE12-dist-na 9.8738 APE11-dist-na 11.6283 APE10-dist-na 16.1461 APE9-dist-out 12.7464 W659A,W777A,F794H None None XRAY 2.0 0.18 0.22 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut4 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT5A O60674 537 808 1132.0 2HB:905 Type1 Pseudo DFGin 7.1887 13.2929 None -93.16, 174.58 -69.71, 153.91 -76.54, -10.06 29.7, 141.93 72.88, -178.86 in-na in 9.8227 Saltbr-na 999.0 HRD-in -86.78, -65.09 96.66, -4.13 na-out-out SNCaoo out-out ActLoopNT-out 9.8918 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.35, -36.77 APE9-dihe-out -64.06, -22.66 APE8-dihe-out -88.95, 4.87 APE8-rot-na 294.92 APE67-dihe-out -99.37, 27.39 -66.22, 138.89 APE12-dist-na 10.0661 APE11-dist-na 11.6537 APE10-dist-na 16.2639 APE9-dist-out 12.8254 W659A,W777A,F794H None None XRAY 1.9 0.162 0.201 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut5 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT6A O60674 537 808 1132.0 8MY:901 Type1 Pseudo DFGin 7.8108 13.3833 None -94.36, -179.3 -74.79, 159.2 -78.43, -9.68 26.67, 142.51 69.48, -170.15 in-na in 9.7616 Saltbr-na 999.0 HRD-in -88.85, -58.65 93.81, -8.0 na-out-out SNCaoo out-out ActLoopNT-out 9.8903 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.58, -38.89 APE9-dihe-out -63.87, -22.26 APE8-dihe-out -88.04, 3.04 APE8-rot-na 294.63 APE67-dihe-out -105.83, 26.71 -62.56, 137.4 APE12-dist-na 10.0473 APE11-dist-na 11.6725 APE10-dist-na 16.2366 APE9-dist-out 13.0236 W659A,W777A,F794H None None XRAY 1.645 0.169 0.206 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut6 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BRWA O60674 537 808 1132.0 5BS:901 Type1 Pseudo DFGin 7.7052 13.3794 None -93.41, 174.89 -67.04, 156.04 -83.01, 0.59 33.82, 139.96 67.03, -167.12 in-na in 9.6698 Saltbr-na 999.0 HRD-in -76.15, -62.39 95.18, -6.76 na-out-out SNCaoo out-out ActLoopNT-out 9.3464 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.9, -35.05 APE9-dihe-out -58.77, -25.82 APE8-dihe-out -90.17, 2.34 APE8-rot-na 284.96 APE67-dihe-out -99.82, 21.48 -62.86, 134.79 APE12-dist-na 9.9909 APE11-dist-na 11.5633 APE10-dist-na 16.1812 APE9-dist-out 12.8111 W659A,W777A,F794H None None XRAY 2.031 0.197 0.25 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6brw Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BS0A O60674 537 808 1132.0 E4V:901 Type1 Pseudo DFGin 7.0805 13.2557 None -88.58, 177.61 -73.17, 156.09 -79.5, -8.28 28.34, 142.63 71.71, -176.36 in-na in 9.568 Saltbr-na 999.0 HRD-in -86.4, -62.0 95.3, -5.83 na-out-out SNCaoo out-out ActLoopNT-out 9.9043 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.75, -38.73 APE9-dihe-out -60.18, -24.31 APE8-dihe-out -91.13, 4.36 APE8-rot-na 292.13 APE67-dihe-out -103.61, 24.99 -63.19, 136.77 APE12-dist-na 10.05 APE11-dist-na 11.6293 APE10-dist-na 16.2311 APE9-dist-out 12.9298 W659A,W777A,F794H None None XRAY 1.541 0.162 0.195 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6bs0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BSSA O60674 537 808 1132.0 4SP:902 Type1 Pseudo DFGin 7.5682 13.5106 None -92.12, 176.26 -71.33, 155.06 -76.95, -9.06 29.95, 143.27 73.96, -170.06 in-na in 9.6875 Saltbr-na 999.0 HRD-in -85.06, -63.73 98.07, -5.96 na-out-out SNCaoo out-out ActLoopNT-out 9.8876 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.01, -35.23 APE9-dihe-out -61.99, -26.69 APE8-dihe-out -86.73, 3.75 APE8-rot-na 289.32 APE67-dihe-out -100.38, 23.52 -64.28, 136.45 APE12-dist-na 9.9849 APE11-dist-na 11.5508 APE10-dist-na 16.1873 APE9-dist-out 12.8821 W659A,W777A,F794H None None XRAY 2.1 0.194 0.235 A 289.0 271.0 1 24 24 0 [[545, 807], [849, 1125]] 2.0 6bss Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6M9HA O60674 536 808 1132.0 J9D:901 Type1 Pseudo DFGin 7.8658 13.1991 None -93.81, -179.33 -75.36, 156.59 -79.44, -11.27 28.67, 140.35 75.69, -170.14 in-na in 9.7885 Saltbr-na 999.0 HRD-in -82.1, -57.99 92.46, -9.79 na-out-out SNCaoo out-out ActLoopNT-out 9.792 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.63, -41.5 APE9-dihe-out -66.06, -19.63 APE8-dihe-out -87.45, 2.93 APE8-rot-na 291.17 APE67-dihe-out -101.95, 25.55 -63.43, 136.79 APE12-dist-na 10.0491 APE11-dist-na 11.5902 APE10-dist-na 16.2066 APE9-dist-out 12.9593 W659A,W777A,F794H None None XRAY 1.79 0.172 0.206 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6m9h Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OAVA O60674 537 808 1132.0 M3A:901 Type1 Pseudo DFGin 7.1118 13.0392 None -89.82, 175.57 -71.85, 155.92 -76.93, -12.28 28.1, 145.13 74.45, -170.6 in-na in 9.8149 Saltbr-na 999.0 HRD-in -81.92, -60.26 97.52, -13.09 na-out-out SNCaoo out-out ActLoopNT-out 9.6491 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.27, -33.28 APE9-dihe-out -70.41, -15.65 APE8-dihe-out -94.12, 2.48 APE8-rot-na 295.49 APE67-dihe-out -103.53, 27.01 -62.67, 134.47 APE12-dist-na 9.9283 APE11-dist-na 11.4908 APE10-dist-na 16.0829 APE9-dist-out 12.7056 W659A,W777A,F794H None None XRAY 1.939 0.202 0.236 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6oav Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBBA O60674 537 808 1132.0 M3Y:901 Type1 Pseudo DFGin 7.3423 13.2339 None -84.34, 177.39 -74.24, 159.35 -79.81, -16.97 27.48, 144.61 78.13, -168.92 out-na out 10.1344 Saltbr-na 999.0 HRD-in -82.45, -60.11 93.59, -13.21 na-out-out SNCaoo out-out ActLoopNT-out 9.7343 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -38.37 APE9-dihe-out -67.29, -18.2 APE8-dihe-out -91.42, 5.55 APE8-rot-na 289.4 APE67-dihe-out -101.89, 28.31 -66.13, 136.22 APE12-dist-na 9.9763 APE11-dist-na 11.4381 APE10-dist-na 16.1001 APE9-dist-out 12.826 W659A,W777A,F794H None None XRAY 1.904 0.197 0.225 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obb Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBFA O60674 537 808 1132.0 M4G:902 Type1 Pseudo DFGin 5.8016 13.5747 None -75.4, 175.18 -69.61, 155.48 -61.14, -31.23 333.27, 38.74 78.42, -174.91 out-na out 11.7301 Saltbr-na 999.0 HRD-in -79.03, -58.03 90.73, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.1257 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.35, -37.95 APE9-dihe-out -66.08, -20.0 APE8-dihe-out -89.74, 3.4 APE8-rot-na 287.78 APE67-dihe-out -103.65, 28.29 -65.52, 135.12 APE12-dist-na 9.8761 APE11-dist-na 11.4144 APE10-dist-na 16.0183 APE9-dist-out 12.5198 W659A,W777A,F794H None None XRAY 1.71 0.199 0.222 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obf Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBLA O60674 537 808 1132.0 M4P:901 Type1 Pseudo DFGin 6.1314 13.618 None -84.06, 175.88 -72.71, 160.31 -68.63, -25.11 336.97, 36.63 73.61, -166.98 out-na out 11.5997 Saltbr-na 999.0 HRD-in -78.47, -60.55 94.84, -3.9 na-out-out SNCaoo out-out ActLoopNT-out 9.0751 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.59, -34.77 APE9-dihe-out -65.45, -25.46 APE8-dihe-out -86.12, 6.91 APE8-rot-na 289.77 APE67-dihe-out -101.28, 22.22 -64.94, 134.76 APE12-dist-na 9.8653 APE11-dist-na 11.3953 APE10-dist-na 16.0439 APE9-dist-out 12.7108 W659A,W777A,F794H None None XRAY 2.061 0.2 0.239 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obl Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OCCA O60674 537 808 1132.0 M57:1002 Type1 Pseudo DFGin 6.0618 13.5692 None -84.33, 174.58 -71.42, 156.44 -66.05, -27.79 338.24, 34.72 78.91, -171.69 out-na out 11.7166 Saltbr-na 999.0 HRD-in -79.87, -63.55 97.41, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.2604 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.17, -40.0 APE9-dihe-out -66.58, -22.02 APE8-dihe-out -86.2, 2.55 APE8-rot-na 295.02 APE67-dihe-out -102.04, 27.42 -65.31, 136.06 APE12-dist-na 9.937 APE11-dist-na 11.4119 APE10-dist-na 16.0003 APE9-dist-out 12.4336 W659A,W777A,F794H None None XRAY 2.03 0.227 0.272 A 289.0 268.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6occ Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6XJKA O60674 539 807 1132.0 V4D:901 Type1 Pseudo DFGin 7.0861 13.1101 None -82.39, -178.8 -73.6, 159.61 -82.47, -18.87 26.68, 148.75 79.98, -172.67 out-na out 10.9429 Saltbr-na 999.0 HRD-in -78.39, -61.79 94.59, -5.62 na-out-out SNCaoo out-out ActLoopNT-out 9.1768 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.63, -38.8 APE9-dihe-out -69.88, -19.28 APE8-dihe-out -90.06, 4.72 APE8-rot-na 291.97 APE67-dihe-out -100.24, 24.73 -62.96, 137.34 APE12-dist-na 9.833 APE11-dist-na 11.6512 APE10-dist-na 16.1346 APE9-dist-out 12.5371 W659A,W777A,F794H None None XRAY 2.024 0.229 0.273 A 289.0 265.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6xjk Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYOA O60674 539 808 1132.0 VPS:901 Type1 Pseudo DFGin 7.3133 13.2651 None -88.9, -179.5 -76.4, 155.67 -78.17, -11.76 25.61, 146.28 75.85, -168.38 in-na in 9.9397 Saltbr-na 999.0 HRD-in -78.1, -62.53 100.04, -11.32 na-out-out SNCaoo out-out ActLoopNT-out 9.47 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.05, -35.44 APE9-dihe-out -67.28, -21.98 APE8-dihe-out -89.32, 5.73 APE8-rot-na 292.48 APE67-dihe-out -104.2, 24.04 -63.78, 134.25 APE12-dist-na 10.0063 APE11-dist-na 11.4947 APE10-dist-na 16.0721 APE9-dist-out 12.6709 W659A,W777A,F794H None None XRAY 2.161 0.188 0.246 A 289.0 270.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7jyo Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYQA O60674 537 808 1132.0 VPJ:902 Type1 Pseudo DFGin 7.645 13.0055 None -92.98, -175.16 -77.54, 154.64 -78.8, -12.58 29.28, 143.4 74.39, -171.67 out-na out 13.0732 Saltbr-na 999.0 HRD-in -86.04, -59.14 96.24, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8115 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.31, -38.61 APE9-dihe-out -62.73, -23.3 APE8-dihe-out -89.27, 2.43 APE8-rot-na 292.66 APE67-dihe-out -102.33, 26.3 -62.62, 135.22 APE12-dist-na 10.0152 APE11-dist-na 11.5681 APE10-dist-na 16.1683 APE9-dist-out 12.8664 W659A,W777A,F794H None None XRAY 1.859 0.181 0.221 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7jyq Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7SZWA O60674 537 808 1132.0 DVY:901 Type1 Pseudo DFGin 6.4516 13.2599 None -82.57, 177.58 -73.21, 157.07 -69.74, -29.09 341.81, 33.15 77.93, -172.46 out-na out 12.3056 Saltbr-na 999.0 HRD-in -80.57, -59.83 95.34, -11.68 na-out-out SNCaoo out-out ActLoopNT-out 9.2552 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -37.85 APE9-dihe-out -63.74, -25.15 APE8-dihe-out -91.51, 8.03 APE8-rot-na 297.58 APE67-dihe-out -99.24, 24.79 -65.54, 137.42 APE12-dist-na 9.9259 APE11-dist-na 11.4265 APE10-dist-na 16.0645 APE9-dist-out 12.4083 W659A,W777A,F794H None None XRAY 1.906 0.195 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7szw Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PA O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.5356 13.4525 None -71.36, 169.62 -64.37, 154.19 -64.4, -34.91 335.03, 35.41 82.73, -164.25 out-na out 11.6251 Saltbr-na 999.0 HRD-in -78.49, -60.16 92.47, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.4113 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.7, -41.68 APE9-dihe-out -61.62, -27.73 APE8-dihe-out -89.13, 13.42 APE8-rot-na 292.46 APE67-dihe-out -104.69, 27.09 -67.15, 136.9 APE12-dist-na 10.1283 APE11-dist-na 11.4772 APE10-dist-na 16.1721 APE9-dist-out 12.8246 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t0p Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PB O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.5841 13.3753 None -73.4, 171.14 -67.99, 156.9 -65.04, -35.98 333.3, 36.74 84.58, -160.86 out-na out 11.6751 Saltbr-na 999.0 HRD-in -82.44, -59.87 91.7, -5.68 na-out-out SNCaoo out-out ActLoopNT-out 9.5252 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.77, -34.38 APE9-dihe-out -70.23, -20.91 APE8-dihe-out -95.01, 13.79 APE8-rot-na 294.77 APE67-dihe-out -106.03, 28.99 -67.37, 133.92 APE12-dist-na 10.0828 APE11-dist-na 11.624 APE10-dist-na 16.2602 APE9-dist-out 12.9567 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 B 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t0p Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T1TA O60674 536 809 1132.0 E8I:901 Type1 Pseudo DFGin 7.0745 13.1989 None -85.56, -179.34 -72.27, 154.59 -78.75, -8.81 22.02, 154.16 65.96, -165.49 out-na out 10.8121 Saltbr-na 999.0 HRD-in -83.69, -59.16 91.95, -7.4 na-out-out SNCaoo out-out ActLoopNT-out 9.7297 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.83, -40.65 APE9-dihe-out -65.84, -24.48 APE8-dihe-out -87.52, 8.41 APE8-rot-na 292.81 APE67-dihe-out -105.4, 28.45 -65.24, 133.84 APE12-dist-na 9.9478 APE11-dist-na 11.6118 APE10-dist-na 16.1823 APE9-dist-out 12.9375 W659A,W777A,F794H None None XRAY 2.08 0.183 0.228 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t1t Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.0102 13.3074 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.0967 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.1429 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.4338 APE10-dist-na 15.9334 APE9-dist-out 12.4277 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9h Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA3A O60674 536 812 1132.0 Q8U:60901 Type1 Pseudo DFGin 7.9449 13.7079 None -77.62, 172.89 -67.28, 156.81 -77.15, -9.78 24.71, 146.25 70.37, -168.01 out-na out 10.5812 Saltbr-na 999.0 HRD-in -73.02, -63.41 91.28, -5.41 na-out-out SNCaoo out-out ActLoopNT-out 8.8315 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.97, -37.88 APE9-dihe-out -69.87, -18.94 APE8-dihe-out -88.79, 5.92 APE8-rot-na 290.58 APE67-dihe-out -110.89, 28.54 -69.8, 129.69 APE12-dist-na 10.0415 APE11-dist-na 11.8896 APE10-dist-na 16.4253 APE9-dist-out 12.5092 W659A,W777A,F794H None None XRAY 1.4 0.175 0.197 A 289.0 277.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba3 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX0A O60674 536 808 1132.0 AQG:901 Type1 Pseudo DFGin 7.4123 13.4018 None -87.55, 174.91 -71.81, 159.18 -77.63, -11.45 24.29, 145.18 73.87, -172.91 in-na in 9.643 Saltbr-na 999.0 HRD-in -81.87, -61.41 94.19, -7.67 na-out-out SNCaoo out-out ActLoopNT-out 9.6084 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.42, -37.24 APE9-dihe-out -64.33, -22.0 APE8-dihe-out -89.33, 0.5 APE8-rot-na 287.44 APE67-dihe-out -103.06, 26.06 -59.07, 135.76 APE12-dist-na 9.8884 APE11-dist-na 11.5611 APE10-dist-na 16.1357 APE9-dist-out 12.686 W659A,W777A,F794H None None XRAY 1.85 0.179 0.228 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX1A O60674 537 808 1132.0 AD5:901 Type1 Pseudo DFGin 7.2822 13.5699 None -94.73, 174.88 -71.85, 156.73 -78.3, -7.64 23.96, 145.89 75.85, -176.26 in-na in 9.8513 Saltbr-na 999.0 HRD-in -83.17, -61.66 95.43, -4.68 na-out-out SNCaoo out-out ActLoopNT-out 9.7446 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.78, -38.61 APE9-dihe-out -63.17, -26.48 APE8-dihe-out -86.79, 6.17 APE8-rot-na 291.87 APE67-dihe-out -106.59, 26.74 -65.58, 134.04 APE12-dist-na 9.8512 APE11-dist-na 11.5504 APE10-dist-na 16.0568 APE9-dist-out 12.7733 W659A,W777A,F794H None None XRAY 1.5 0.169 0.191 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex1 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX2A O60674 536 808 1132.0 Q2Q:901 Type1 Pseudo DFGin 7.6828 13.3897 None -89.91, 173.83 -74.44, 158.35 -75.25, -10.25 27.64, 142.49 74.64, -169.3 in-na in 9.7258 Saltbr-na 999.0 HRD-in -84.46, -65.65 96.23, -6.71 na-out-out SNCaoo out-out ActLoopNT-out 9.5614 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.11, -41.46 APE9-dihe-out -59.07, -26.71 APE8-dihe-out -87.22, 3.02 APE8-rot-na 287.18 APE67-dihe-out -104.5, 26.8 -63.95, 134.55 APE12-dist-na 9.9758 APE11-dist-na 11.51 APE10-dist-na 16.1308 APE9-dist-out 12.6339 W659A,W777A,F794H None None XRAY 1.9 0.172 0.203 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex2 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.7e-64 222.9 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND5A O60674 536 809 1132.0 A1BXA:901 Type1 Pseudo DFGin 7.1967 13.4361 None -78.37, 174.28 -71.06, 155.85 -82.01, -13.03 28.16, 149.91 71.45, -157.96 out-na out 10.3765 Saltbr-na 999.0 HRD-in -81.65, -70.18 103.7, -2.47 na-out-out SNCaoo out-out ActLoopNT-out 9.4735 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -76.62, -29.08 APE9-dihe-out -76.41, -20.7 APE8-dihe-out -84.83, 10.94 APE8-rot-na 287.64 APE67-dihe-out -108.27, 36.81 -81.67, 130.11 APE12-dist-na 9.6535 APE11-dist-na 11.4413 APE10-dist-na 16.0178 APE9-dist-out 12.4531 None None None XRAY 2.4 0.214 0.278 A 280.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 9nd5 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.8e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND3A O60674 536 808 1132.0 A1BW6:901 Type1 Pseudo DFGin 5.9957 13.1158 None -64.1, 173.67 -70.95, 163.72 -78.01, -24.74 341.83, 32.74 77.82, -165.18 out-na out 11.374 Saltbr-na 999.0 HRD-in -84.19, -60.63 89.29, -1.33 na-out-out SNCaoo out-out ActLoopNT-out 9.1954 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.37, -39.11 APE9-dihe-out -58.8, -29.7 APE8-dihe-out -87.32, 4.81 APE8-rot-na 289.91 APE67-dihe-out -104.68, 28.28 -65.86, 133.14 APE12-dist-na 9.6569 APE11-dist-na 11.4611 APE10-dist-na 16.0024 APE9-dist-out 12.276 None None None XRAY 1.62 0.189 0.22 A 283.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 9nd3 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5TQ3A O60674 843 1132 1132.0 7GZ:4000 Type1.5_Back Inactive DFGin 6.7366 14.7991 None 172.87, 131.46 -138.34, 98.39 -97.83, 27.37 287.51, 86.01 -80.9, -8.4 in-in in 8.5838 Saltbr-in 2.8363 HRD-in -60.87, -46.98 70.99, 1.64 in-in-in SNCiii in-in ActLoopNT-in 2.9485 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.52, 122.1 APE9-dihe-in -107.12, 143.94 APE8-dihe-in -76.54, 73.52 APE8-rot-na 28.78 APE67-dihe-in -71.43, -5.04 -57.67, -36.56 APE12-dist-na 9.1516 APE11-dist-na 10.6276 APE10-dist-na 11.3857 APE9-dist-in 7.3259 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.69 0.219 0.271 A 304.0 284.0 6 31 29 2 [[545, 807], [849, 1125]] 2.0 5tq3 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5TQ3B O60674 843 1132 1132.0 7GZ:4001 Type1.5_Back Inactive DFGin 6.7371 14.7977 None 175.33, 157.26 -141.41, 99.71 -97.33, 27.05 288.19, 85.47 -80.15, -9.61 in-in in 8.5742 Saltbr-in 2.8801 HRD-in -62.69, -46.43 69.37, 2.93 in-in-in SNCiii in-in ActLoopNT-in 2.9552 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.61, 127.26 APE9-dihe-in -88.47, 146.55 APE8-dihe-in -72.07, 80.22 APE8-rot-na 34.9 APE67-dihe-in -69.96, -5.59 -60.36, -37.68 APE12-dist-na 12.1436 APE11-dist-na 10.8771 APE10-dist-na 11.8755 APE9-dist-in 7.1992 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.69 0.219 0.271 B 304.0 287.0 3 31 31 0 [[545, 807], [849, 1125]] 2.0 5tq3 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR KDR VGFR2_HUMAN 1VR2A P35968 820 1168 1356.0 No_ligand No_ligand Inactive DFGin 6.1971 12.2007 None -132.36, 167.84 67.89, 27.54 -86.08, 999.0 49.78, 130.84 999.0, 999.0 in-in in 7.7298 Saltbr-in 2.9904 HRD-in -66.37, -43.4 76.06, -15.34 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.43, 155.04 APE9-dihe-in -108.73, 90.95 APE8-dihe-out -47.33, -14.52 APE8-rot-na 323.83 APE67-dihe-in -64.29, -7.8 -69.97, -29.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.4665 E990V PTR1059 PTR1059 XRAY 2.4 0.215 999.0 A 316.0 275.0 24 30 14 16 [[834, 1162]] 1.0 1vr2 Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR LYN LYN_HUMAN 3A4OX P07948 238 505 512.0 STU:60902 Type1 Inactive DFGin 6.6497 15.5814 None -103.69, -177.97 54.14, 148.85 -166.58, 42.86 276.85, 106.11 -75.66, -40.91 in-in in 9.1227 Saltbr-in 3.2202 HRD-in -82.15, -55.06 93.66, -27.17 in-in-out SNCiio in-out ActLoopNT-in 2.8615 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out -155.78, -36.41 APE9-dihe-out 3.09, -67.88 APE8-dihe-in -48.66, 80.66 APE8-rot-na 28.53 APE67-dihe-in -67.02, 39.44 -53.16, -65.62 APE12-dist-na 7.583 APE11-dist-na 3.3978 APE10-dist-na 8.537 APE9-dist-in 6.4504 None None None XRAY 3.0 0.293 0.324 X 286.0 259.0 9 29 20 9 [[247, 499]] 1.0 3a4o Homo sapiens TYR_LYN_HUMAN TYR 1.2e-95 325.7 1.0 260.0 260.0 384 385 386 388 390 275 290 294 364 366 365 367.0 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
TYR MERTK MERTK_HUMAN 5TD2B Q12866 577 861 999.0 No_ligand No_ligand Inactive DFGin 6.7934 13.1159 None -144.11, 174.62 61.92, 63.15 -77.51, 999.0 303.45, 94.64 999.0, 999.0 out-out out 13.3511 Saltbr-out 12.416 HRD-in -68.4, -50.94 72.94, 5.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.34 APE8-rot-na 32.97 APE67-dihe-in -69.61, -9.75 -67.34, -19.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.251 0.3 B 285.0 242.0 43 30 10 20 [[587, 856]] 1.0 5td2 Homo sapiens TYR_MERTK_HUMAN TYR 2.9e-92 314.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MH7B Q12866 577 862 999.0 No_ligand No_ligand Inactive DFGin 6.2369 12.8082 None -148.47, -179.73 64.64, 46.7 -122.89, 999.0 48.11, 70.87 999.0, 999.0 out-out out 12.8965 Saltbr-out 12.9259 HRD-in -78.94, -52.07 71.09, 5.48 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.45 APE8-rot-na 30.55 APE67-dihe-in -77.17, 1.49 -58.85, -30.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.51 0.228 0.279 B 313.0 255.0 31 30 10 20 [[587, 856]] 1.0 4mh7 Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TC0B Q12866 578 861 999.0 No_ligand No_ligand Inactive DFGin 5.9768 12.8785 None -140.01, 177.82 66.06, 34.51 -92.54, 999.0 25.62, 68.77 999.0, 999.0 out-out out 12.9501 Saltbr-out 9.125 HRD-in -84.36, -52.52 74.32, 6.07 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.67 APE8-rot-na 31.87 APE67-dihe-in -69.09, -5.19 -56.41, -41.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.24 0.229 0.262 B 314.0 250.0 34 30 10 20 [[587, 856]] 1.0 5tc0 Homo sapiens TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB0A Q12866 571 862 999.0 No_ligand No_ligand Inactive DFGin 6.6237 14.0135 None -143.7, 175.11 61.44, 47.67 -68.22, 999.0 316.54, 102.57 999.0, 999.0 out-out out 13.2638 Saltbr-out 14.3456 HRD-in -75.07, -54.59 74.43, 4.28 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.53 APE8-rot-na 33.09 APE67-dihe-in -75.24, -3.15 -51.47, -40.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.74 0.202 0.246 A 298.0 267.0 25 30 10 20 [[587, 856]] 1.0 7ab0 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TD2A Q12866 577 861 999.0 7AE:1000 Type1 Inactive DFGin 6.1343 13.6506 None -143.3, 174.43 65.95, 82.51 -104.11, 999.0 312.2, 105.07 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.96, -51.07 72.28, 6.41 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 97.89 APE8-rot-na 25.82 APE67-dihe-in -75.54, -1.44 -65.62, -42.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.251 0.3 A 285.0 240.0 45 30 10 20 [[587, 856]] 1.0 5td2 Homo sapiens TYR_MERTK_HUMAN TYR 2.9e-92 314.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OAMB Q12866 576 862 999.0 V6H:60901 Type1 Inactive DFGin 7.0066 13.4567 None -146.0, 178.63 58.31, 50.5 -120.77, 999.0 46.98, 69.39 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.67, -62.84 85.61, -10.13 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 97.98 APE8-dihe-in -79.78, 85.21 APE8-rot-na 33.46 APE67-dihe-in -75.72, -1.35 -61.95, -25.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5175 None None None XRAY 2.65 0.224 0.257 B 296.0 250.0 37 30 11 19 [[587, 856]] 1.0 7oam Homo sapiens TYR_MERTK_HUMAN TYR 1.1e-92 315.9 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3TCPA Q12866 577 863 999.0 CKJ:1 Type1 Inactive DFGin 6.2033 12.8934 None -136.14, -178.38 58.94, 40.23 -104.0, 999.0 45.8, 90.86 999.0, 999.0 out-out out 13.0698 Saltbr-out 10.0871 HRD-in -71.3, -54.4 78.76, -16.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.51 APE8-rot-na 24.96 APE67-dihe-in -68.45, -1.97 -46.97, -39.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.69 0.228 0.298 A 313.0 256.0 31 30 10 20 [[587, 856]] 1.0 3tcp Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3TCPB Q12866 576 861 999.0 CKJ:2 Type1 Inactive DFGin 6.542 12.7247 None -151.12, -175.9 57.3, 28.48 -93.29, 999.0 44.8, 72.64 999.0, 999.0 out-none out 12.0114 Saltbr-none 999.0 HRD-in -62.48, -45.95 68.1, -10.21 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -34.04 APE8-dihe-in -94.24, 71.38 APE8-rot-na 31.8 APE67-dihe-in -76.89, -2.28 -48.4, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2614 None None None XRAY 2.69 0.228 0.298 B 313.0 250.0 36 30 11 19 [[587, 856]] 1.0 3tcp Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4M3QA Q12866 578 861 999.0 24K:906 Type1 Inactive DFGin 5.9623 13.2718 None -156.18, 179.21 59.94, 63.59 -121.26, 999.0 26.4, 60.96 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -76.83, -49.1 68.2, 10.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -8.28 APE8-rot-na 30.83 APE67-dihe-in -76.46, 5.82 -62.87, -37.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.718 0.248 0.296 A 313.0 243.0 41 30 10 20 [[587, 856]] 1.0 4m3q Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MH7A Q12866 577 861 999.0 MH7:906 Type1 Inactive DFGin 6.6728 13.7335 None -149.88, -177.32 66.64, 46.5 -124.55, 999.0 44.22, 68.98 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.51, -51.41 72.09, 3.88 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.58 APE8-rot-na 30.75 APE67-dihe-in -78.5, 1.01 -58.56, -31.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.51 0.228 0.279 A 313.0 248.0 37 30 10 20 [[587, 856]] 1.0 4mh7 Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 4MHAB Q12866 577 862 999.0 4MH:905 Type1 Inactive DFGin 5.588 13.1656 None -164.91, -178.11 62.75, 50.05 -120.6, 999.0 47.74, 75.91 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -87.47, -43.02 65.67, 7.44 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 102.4 APE8-rot-na 29.27 APE67-dihe-in -76.83, 2.21 -113.8, -35.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.246 0.294 B 313.0 246.0 40 30 10 20 [[587, 856]] 1.0 4mha Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5K0KB Q12866 577 862 999.0 6Q1:904 Type1 Inactive DFGin 6.1892 13.3888 None -144.02, -179.34 56.66, 60.57 -135.11, 999.0 52.83, 74.37 999.0, 999.0 out-out out 12.8302 Saltbr-out 9.0057 HRD-in -81.18, -49.68 74.51, -7.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.62 APE8-rot-na 27.52 APE67-dihe-in -73.94, -3.99 -57.79, -40.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.545 0.203 0.254 B 313.0 248.0 38 30 10 20 [[587, 856]] 1.0 5k0k Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5TC0A Q12866 578 861 999.0 79Y:1100 Type1 Inactive DFGin 5.868 13.0928 None -140.95, 176.68 72.06, 53.5 -127.68, 999.0 35.95, 63.07 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.04, -52.33 70.75, 9.58 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 51.99 APE8-dihe-in -70.22, 110.63 APE8-rot-na 29.77 APE67-dihe-in -71.61, -2.78 -54.4, -35.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.1839 None None None XRAY 2.24 0.229 0.262 A 314.0 238.0 46 30 11 19 [[587, 856]] 1.0 5tc0 Homo sapiens TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5U6CA Q12866 572 864 999.0 7YS:9001 Type1 Inactive DFGin 6.5138 13.097 None -140.41, -178.19 73.14, -58.25 59.05, 38.04 321.05, 119.16 47.3, 38.19 out-out out 12.2383 Saltbr-out 10.4104 HRD-in -76.31, -59.9 77.64, -5.13 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -19.89 APE8-rot-na 24.77 APE67-dihe-in -66.57, -0.63 -47.81, -46.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.214 0.257 A 315.0 272.0 21 30 13 17 [[587, 856]] 1.0 5u6c Homo sapiens TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 5U6CB Q12866 575 862 999.0 7YS:9001 Type1 Inactive DFGin 5.7559 13.3901 None -146.75, -178.14 49.0, 37.86 -93.39, 999.0 43.6, 77.83 999.0, 999.0 out-out out 13.8564 Saltbr-out 11.1074 HRD-in -77.29, -57.91 76.71, -6.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.75 APE8-dihe-in -83.33, 57.19 APE8-rot-na 31.94 APE67-dihe-in -71.79, -2.99 -38.38, -48.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0609 None None None XRAY 2.1 0.214 0.257 B 315.0 257.0 31 30 11 19 [[587, 856]] 1.0 5u6c Homo sapiens TYR_MERTK_HUMAN TYR 4.1e-92 314.1 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB1A Q12866 571 862 999.0 C6F:60901 Type1 Inactive DFGin 5.8722 13.5268 None -150.27, 178.21 48.78, 48.66 -107.87, 999.0 41.9, 85.18 999.0, 999.0 out-out out 12.8443 Saltbr-out 9.5657 HRD-in -84.92, -52.07 85.67, -41.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.29 APE8-rot-na 36.31 APE67-dihe-in -65.53, -14.5 -57.08, -42.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.93 0.237 0.298 A 298.0 267.0 25 30 10 20 [[587, 856]] 1.0 7ab1 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB2A Q12866 571 862 999.0 R6N:60901 Type1 Inactive DFGin 6.3276 13.5883 None -148.22, 175.53 55.93, 53.34 -74.83, 999.0 329.09, 104.95 999.0, 999.0 out-out out 13.2033 Saltbr-out 14.5703 HRD-in -79.16, -56.47 81.41, -4.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 64.62 APE8-rot-na 36.54 APE67-dihe-in -78.04, -6.9 -58.38, -34.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.78 0.196 0.25 A 298.0 267.0 25 30 10 20 [[587, 856]] 1.0 7ab2 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AVZA Q12866 571 862 999.0 S4N:60901 Type1 Inactive DFGin 6.2693 13.5904 None -145.45, 176.2 52.56, 50.67 -72.23, 999.0 339.86, 87.13 999.0, 999.0 out-out out 12.9842 Saltbr-out 9.9233 HRD-in -69.09, -58.13 78.41, -16.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.96 APE8-rot-na 31.06 APE67-dihe-in -76.22, 2.71 -47.31, -44.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 2.04 0.207 0.229 A 298.0 265.0 27 30 10 20 [[587, 856]] 1.0 7avz Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW0A Q12866 571 862 999.0 S4Q:60901 Type1 Inactive DFGin 6.0743 13.887 None -146.33, 175.15 58.08, 44.92 -106.5, 999.0 37.04, 79.3 999.0, 999.0 out-out out 13.1591 Saltbr-out 9.8931 HRD-in -73.83, -55.86 76.62, -13.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.76 APE8-rot-na 19.28 APE67-dihe-in -68.82, -6.08 -45.38, -39.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.893 0.204 0.233 A 298.0 266.0 26 30 10 20 [[587, 856]] 1.0 7aw0 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW3A Q12866 571 862 999.0 S4Z:60901 Type1 Inactive DFGin 6.1357 13.4921 None -141.96, 175.75 54.61, 48.83 -104.75, 999.0 29.07, 73.23 999.0, 999.0 out-out out 13.2531 Saltbr-out 10.1666 HRD-in -76.56, -55.94 78.32, -15.64 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.13 APE8-rot-na 30.36 APE67-dihe-in -72.86, -3.93 -46.59, -40.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.99 0.217 0.245 A 298.0 266.0 26 30 10 20 [[587, 856]] 1.0 7aw3 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7M5ZA Q12866 577 862 999.0 YR7:901 Type1 Inactive DFGin 5.6814 14.1735 None -159.0, -169.59 47.7, 65.14 -69.86, 999.0 300.1, 112.68 999.0, 999.0 in-out in 9.2564 Saltbr-out 6.024 HRD-in -77.96, -43.12 69.37, -0.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 13.83 APE8-rot-na 32.06 APE67-dihe-in -66.59, -6.13 -57.74, -32.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.06 0.265 0.297 A 313.0 263.0 23 30 10 20 [[587, 856]] 1.0 7m5z Homo sapiens TYR_MERTK_HUMAN TYR 2.7e-92 314.7 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 6MEPB Q12866 578 862 999.0 9VS:904 Type1.5_Back Inactive DFGin 6.137 13.7512 None -149.56, -177.34 59.65, 39.31 -110.56, 999.0 52.79, 83.98 999.0, 999.0 out-out out 12.835 Saltbr-out 11.8071 HRD-out -99.49, 96.49 -80.13, -3.87 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.16 APE8-rot-na 30.37 APE67-dihe-in -67.86, -3.3 -78.71, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.893 0.21 0.268 B 313.0 236.0 49 30 10 20 [[587, 856]] 1.0 6mep Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3EFKA P08581 1054 1351 1390.0 MT4:1 Type1.5_Front Inactive DFGin 5.0636 14.0927 None -134.75, -178.01 61.2, 27.83 -81.51, 999.0 42.72, 82.19 999.0, 999.0 out-out out 12.8128 Saltbr-out 7.9409 HRD-in -70.71, -51.36 83.62, -19.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 26.89 APE8-rot-na 29.1 APE67-dihe-in -75.12, -5.25 -59.44, -32.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L1272L None None XRAY 2.2 0.257 0.292 A 310.0 276.0 22 32 10 22 [[1078, 1339]] 1.0 3efk Homo sapiens TYR_MET_HUMAN TYR 7e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKB P08581 1054 1351 1390.0 MT4:2 Type1.5_Front Inactive DFGin 5.1715 14.1711 None -136.11, -178.89 60.83, 31.64 -88.75, 999.0 42.99, 77.64 999.0, 999.0 out-out out 12.549 Saltbr-out 7.6229 HRD-in -66.0, -59.6 86.12, -12.02 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 28.71 APE8-rot-na 33.98 APE67-dihe-in -75.58, -3.26 -55.05, -32.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L1272L None None XRAY 2.2 0.257 0.292 B 310.0 272.0 26 32 10 22 [[1078, 1339]] 1.0 3efk Homo sapiens TYR_MET_HUMAN TYR 7e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4PMTA P04629 501 787 796.0 31Y:60801 Type1 Inactive DFGin 6.1314 14.794 None -112.67, -17.01 -137.68, 145.04 -146.35, 999.0 322.04, 80.71 999.0, 999.0 in-out in 9.8065 Saltbr-out 3.6332 HRD-in -75.33, -51.24 80.98, -15.04 out-out-in SNCooi out-in ActLoopNT-out 15.615 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.06, 128.33 APE9-dihe-in -117.66, 131.56 APE8-dihe-in -80.54, 63.91 APE8-rot-na 31.59 APE67-dihe-in -62.62, -22.15 -50.58, -36.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2177 None None None XRAY 2.1 0.186 0.209 A 291.0 269.0 18 30 25 5 [[510, 783]] 1.0 4pmt Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5I8AA P04629 501 787 796.0 69C:60801 Type1 Inactive DFGin 6.738 14.3896 None -97.16, -113.31 -48.28, 144.89 -102.36, 10.49 289.66, 94.22 178.06, 999.0 in-in in 9.6286 Saltbr-in 3.266 HRD-in -70.07, -53.33 85.54, -20.79 in-out-in SNCioi out-in ActLoopNT-out 17.1271 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.82, 123.59 APE9-dihe-in -112.87, 128.48 APE8-dihe-in -77.41, 62.86 APE8-rot-na 29.5 APE67-dihe-in -66.17, -22.6 -48.87, -35.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2452 None None None XRAY 2.33 0.18 0.209 A 296.0 266.0 21 30 26 4 [[510, 783]] 1.0 5i8a Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6IQNA P04629 502 790 796.0 AQ6:60801 Type1 Inactive DFGin 7.14 15.1103 None -103.61, -29.7 -117.2, -70.49 62.55, 999.0 316.84, 95.5 999.0, 999.0 in-out in 9.7917 Saltbr-out 4.8101 HRD-in -72.08, -53.46 85.54, -25.89 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.52, 109.29 APE9-dihe-in -102.41, 128.27 APE8-dihe-in -77.64, 69.03 APE8-rot-na 26.82 APE67-dihe-in -69.77, -22.47 -58.81, -29.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3302 None None None XRAY 2.54 0.228 0.287 A 296.0 271.0 18 30 18 12 [[510, 783]] 1.0 6iqn Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 7XAFA P04629 498 796 796.0 FKT:801 Type1 Inactive DFGin 10.9726 15.5303 None -141.15, 137.13 74.8, 177.08 49.53, -82.17 307.2, 139.07 -1.5, 80.75 in-out in 9.4808 Saltbr-out 3.7007 HRD-out -81.39, 105.98 -86.3, -0.43 out-out-in SNCooi out-in ActLoopNT-out 15.4378 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.83, 144.52 APE9-dihe-in -128.89, 123.51 APE8-dihe-in -76.16, 66.1 APE8-rot-na 29.0 APE67-dihe-in -71.14, -21.57 -60.15, -25.01 APE12-dist-na 15.0229 APE11-dist-na 14.3354 APE10-dist-na 10.4171 APE9-dist-in 7.3626 None None None XRAY 3.001 0.25 0.299 A 299.0 287.0 12 30 30 0 [[510, 783]] 1.0 7xaf Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6J5LA P04629 502 790 796.0 B9C:60801 Type1 Inactive DFGin 6.1274 13.7929 None -112.0, -17.65 -146.4, 142.64 -117.9, -119.21 307.69, 78.13 -102.52, 999.0 in-in in 9.3453 Saltbr-in 3.4221 HRD-out -88.88, 113.33 -93.5, 4.21 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.51, 126.2 APE9-dihe-in -111.04, 133.44 APE8-dihe-in -88.74, 66.42 APE8-rot-na 38.43 APE67-dihe-in -63.3, -23.33 -52.55, -36.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.9327 None None None XRAY 2.3 0.224 0.251 A 303.0 278.0 11 30 23 7 [[510, 783]] 1.0 6j5l Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PMEB P04629 499 791 796.0 OOY:802 Type1 Inactive DFGin 8.0413 12.7752 None -108.23, 50.17 -34.62, -93.7 -97.7, 157.35 268.23, 140.64 158.45, -156.12 in-out in 9.6869 Saltbr-out 4.3617 HRD-in -75.61, -49.56 82.71, -16.4 out-out-none SNCoon out-none ActLoopNT-out 15.6778 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.79 APE9-dihe-in -136.64, 129.71 APE8-dihe-in -72.47, 62.28 APE8-rot-na 30.59 APE67-dihe-in -74.1, -16.42 -50.47, -31.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7569 APE9-dist-in 7.0187 None SEP677 SEP677 XRAY 3.0 0.259 0.315 B 311.0 271.0 22 30 25 5 [[510, 783]] 1.0 6pme Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.3285 15.1025 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.6981 Saltbr-in 3.2532 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4955 None None None XRAY 2.864 0.22 0.277 A 320.0 264.0 32 30 11 19 [[510, 783]] 1.0 9dai Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 7VKOA P04629 502 793 796.0 7GI:60801 Type1 Inactive DFGin 6.3309 13.7935 None -121.29, -23.19 -130.55, 158.61 -131.43, -91.62 300.81, 84.28 -89.58, -178.74 in-out in 9.271 Saltbr-out 4.8438 HRD-out -83.55, 115.94 -93.33, 10.49 out-out-in SNCooi out-in ActLoopNT-out 15.2129 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.01, 135.08 APE9-dihe-in -120.4, 150.84 APE8-dihe-in -84.95, 78.96 APE8-rot-na 37.61 APE67-dihe-in -53.21, -25.59 -47.58, -54.99 APE12-dist-na 10.7383 APE11-dist-na 11.7728 APE10-dist-na 9.7313 APE9-dist-in 6.3483 None None None XRAY 2.9 0.188 0.267 A 326.0 292.0 0 30 30 0 [[510, 783]] 1.0 7vko Homo sapiens TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4AOJB P04629 500 791 796.0 V4Z:900 Type1 Inactive DFGin 7.1015 14.487 None -112.8, -14.1 -146.85, 148.75 -118.66, 999.0 304.25, 74.79 999.0, 999.0 in-out in 9.7738 Saltbr-out 3.7833 HRD-in -81.07, -46.03 78.05, -27.65 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.18 APE8-dihe-in -83.87, 63.88 APE8-rot-na 24.55 APE67-dihe-in -64.26, -27.58 -47.61, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2365 None None None XRAY 2.75 0.221 0.242 B 329.0 258.0 34 30 11 19 [[510, 783]] 1.0 4aoj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK2 NTRK2_HUMAN 4AT3A Q16620 527 822 822.0 LTI:61839 Type1 Inactive DFGin 6.9991 14.7396 None -152.42, -173.22 72.78, -62.99 65.94, 17.52 310.83, 124.61 77.58, 6.11 out-out out 10.154 Saltbr-out 5.3168 HRD-in -64.12, -49.63 78.79, -14.53 out-out-in SNCooi out-in ActLoopNT-out 14.2538 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.1, 112.61 APE9-dihe-in -128.93, 146.94 APE8-dihe-in -81.25, 69.04 APE8-rot-na 31.63 APE67-dihe-in -62.22, -21.09 -43.86, -43.94 APE12-dist-na 17.2682 APE11-dist-na 12.9856 APE10-dist-na 11.6967 APE9-dist-in 6.9412 None None None XRAY 1.77 0.2 0.224 A 299.0 286.0 10 30 28 2 [[538, 809]] 1.0 4at3 Homo sapiens TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
TYR PTK2 FAK1_HUMAN 2IJMA Q05397 414 688 1052.0 ATP:690 ATPlike Inactive DFGin 5.3348 15.2552 None -130.4, -10.41 -96.6, 92.35 -115.09, 154.36 308.92, 97.78 84.66, -9.12 in-in in 7.6024 Saltbr-in 2.5443 HRD-in -77.84, -47.69 90.07, -21.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -43.55 APE8-dihe-in -70.98, 54.52 APE8-rot-na 26.91 APE67-dihe-in -71.31, -14.5 -49.75, -42.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5309 None None None XRAY 2.187 0.211 0.271 A 281.0 260.0 15 29 14 15 [[422, 678]] 1.0 2ijm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 7PI4DDD Q05397 415 687 1052.0 No_ligand No_ligand Inactive DFGin 6.6416 15.7596 None -89.21, -168.8 -53.97, 129.66 -63.34, -43.26 292.53, 5.46 -58.42, -48.1 in-in in 7.4592 Saltbr-in 2.722 HRD-in -72.06, -49.67 76.25, -8.72 in-out-out SNCioo out-out ActLoopNT-out 10.4837 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 141.81 APE9-dihe-in -72.54, 128.52 APE8-dihe-in -81.98, 69.32 APE8-rot-na 34.58 APE67-dihe-in -74.94, -9.99 -55.31, -40.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.0953 APE9-dist-out 8.6378 None None None XRAY 2.24 0.198 0.251 DDD 273.0 264.0 9 29 20 9 [[422, 678]] 1.0 7pi4 Homo sapiens TYR_PTK2_HUMAN TYR 3.1e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 9SDIB Q05397 414 685 1052.0 No_ligand No_ligand Inactive DFGin 4.0046 13.1703 None -97.64, -137.83 -54.67, 146.24 -100.48, 130.01 327.08, 92.25 63.05, 999.0 in-out in 8.1063 Saltbr-out 8.294 HRD-in -82.43, -51.16 74.28, 13.4 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.88 APE8-dihe-in -70.36, 61.66 APE8-rot-na 27.15 APE67-dihe-in -67.38, -13.24 -53.44, -40.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9784 None None None XRAY 2.53 0.184 0.241 B 277.0 255.0 17 29 12 17 [[422, 678]] 1.0 9sdi Homo sapiens TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 3BZ3A Q05397 414 689 1052.0 YAM:1 Type1 Inactive DFGin 6.6719 15.8496 None -79.02, -179.99 -56.66, 136.15 -73.84, -38.07 287.89, 7.91 -61.02, -47.25 in-in in 7.5275 Saltbr-in 2.589 HRD-in -85.54, -56.7 90.17, -10.54 in-out-out SNCioo out-out ActLoopNT-out 10.5565 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.15 APE8-dihe-in -80.58, 72.72 APE8-rot-na 30.9 APE67-dihe-in -70.02, -11.94 -54.79, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1297 None None None XRAY 2.2 0.16 0.234 A 276.0 259.0 17 29 16 13 [[422, 678]] 1.0 3bz3 Homo sapiens TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU9A Q05397 414 685 1052.0 4GU:701 Type1 Inactive DFGin 6.6989 15.7008 None -123.83, 12.04 -117.35, 108.51 -134.16, 999.0 294.29, 94.21 999.0, 999.0 in-in in 7.769 Saltbr-in 3.4919 HRD-in -72.07, -46.62 76.1, -11.95 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.49 APE8-dihe-in -81.89, 65.04 APE8-rot-na 31.19 APE67-dihe-in -69.72, -10.34 -49.89, -42.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6556 None None None XRAY 2.4 0.18 0.221 A 279.0 252.0 20 29 11 18 [[422, 678]] 1.0 4gu9 Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4KABA Q05397 412 686 1052.0 4KA:701 Type1 Inactive DFGin 6.3904 15.555 None -111.52, -14.16 -107.87, 122.87 -138.65, 999.0 293.6, 93.91 999.0, 999.0 in-in in 7.7049 Saltbr-in 3.0591 HRD-in -73.14, -43.25 75.58, -10.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.68 APE8-dihe-in -81.37, 68.28 APE8-rot-na 28.59 APE67-dihe-in -69.97, -11.06 -55.99, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5399 None None None XRAY 2.71 0.173 0.219 A 279.0 255.0 20 29 11 18 [[422, 678]] 1.0 4kab Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6I8ZA Q05397 414 688 1052.0 H82:701 Type1 Inactive DFGin 6.534 15.7387 None -73.65, -177.37 -59.05, 135.57 -69.93, -28.35 299.91, 168.26 -68.89, -44.51 in-in in 7.6007 Saltbr-in 2.8041 HRD-in -70.2, -51.5 74.46, -8.27 in-out-out SNCioo out-out ActLoopNT-out 10.5195 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.99 APE8-dihe-in -84.17, 66.78 APE8-rot-na 36.24 APE67-dihe-in -65.96, -15.87 -53.48, -40.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4163 None None None XRAY 1.99 0.185 0.222 A 281.0 261.0 14 29 15 14 [[422, 678]] 1.0 6i8z Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4I4EA Q05397 414 686 1052.0 1BQ:1000 Type1 Inactive DFGin 6.7896 16.342 None -103.61, -97.99 -1.1, -106.34 55.03, 999.0 299.48, 75.74 999.0, 999.0 in-out in 7.6984 Saltbr-out 3.7485 HRD-in -79.84, -49.84 80.8, -2.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.29 APE8-dihe-in -79.67, 64.72 APE8-rot-na 33.35 APE67-dihe-in -67.06, -11.75 -53.27, -42.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2632 None None None XRAY 1.55 0.166 0.189 A 281.0 254.0 19 29 11 18 [[422, 678]] 1.0 4i4e Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU6A Q05397 414 686 1052.0 10N:701 Type1 Inactive DFGin 6.7252 15.7213 None -78.95, -178.49 -53.69, 136.88 -71.82, -34.41 298.6, 168.4 -65.26, -49.08 in-in in 7.5214 Saltbr-in 2.6966 HRD-in -71.62, -48.61 84.03, -17.12 in-out-out SNCioo out-out ActLoopNT-out 9.6384 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -143.19, 149.54 APE9-dihe-in -51.38, 136.95 APE8-dihe-in -84.93, 56.73 APE8-rot-na 35.61 APE67-dihe-in -63.59, -13.44 -54.64, -43.26 APE12-dist-na 13.4175 APE11-dist-na 11.7698 APE10-dist-na 15.2281 APE9-dist-out 9.3756 None None None XRAY 1.95 0.171 0.194 A 282.0 271.0 2 29 29 0 [[422, 678]] 1.0 4gu6 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4GU6B Q05397 415 686 1052.0 10N:701 Type1 Inactive DFGin 6.7322 15.9506 None -79.45, -179.1 -51.77, 131.29 -67.64, -33.77 299.56, 166.92 -65.8, -45.35 in-in in 7.5272 Saltbr-in 2.7282 HRD-in -73.02, -50.64 78.02, -11.87 in-out-out SNCioo out-out ActLoopNT-out 10.8619 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.41 APE8-dihe-in -75.09, 60.15 APE8-rot-na 31.47 APE67-dihe-in -63.51, -13.22 -52.64, -44.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2437 None None None XRAY 1.95 0.171 0.194 B 282.0 258.0 14 29 15 14 [[422, 678]] 1.0 4gu6 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YOJA Q05397 414 686 1052.0 P4N:701 Type1 Inactive DFGin 6.5173 15.9644 None -76.38, -175.19 -62.53, 137.68 -71.29, -34.87 295.0, 178.59 -63.41, -49.08 in-in in 7.4187 Saltbr-in 2.765 HRD-in -74.52, -48.86 75.74, -8.06 in-out-none SNCion out-none ActLoopNT-out 10.504 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.61 APE8-dihe-in -85.09, 65.79 APE8-rot-na 30.31 APE67-dihe-in -64.59, -10.84 -48.78, -45.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7984 None None None XRAY 1.361 0.172 0.198 A 282.0 259.0 14 29 15 14 [[422, 678]] 1.0 6yoj Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1A Q05397 415 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.7725 15.904 None -76.89, 179.45 -55.75, 133.99 -70.6, -39.73 296.27, 174.79 -61.86, -42.84 in-in in 7.5464 Saltbr-in 2.9126 HRD-in -71.31, -56.22 78.91, -8.0 in-out-out SNCioo out-out ActLoopNT-out 12.1536 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -50.8 APE9-dihe-in -136.97, 142.61 APE8-dihe-in -82.64, 66.53 APE8-rot-na 31.58 APE67-dihe-in -67.94, -11.22 -48.21, -42.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.4702 APE9-dist-out 8.2827 None None None XRAY 1.784 0.184 0.214 A 282.0 269.0 3 29 26 3 [[422, 678]] 1.0 6yq1 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1B Q05397 411 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.896 16.0083 None -76.83, 179.03 -54.23, 132.73 -71.29, -38.79 295.55, 174.7 -61.35, -42.29 in-in in 7.5298 Saltbr-in 2.8646 HRD-in -73.31, -54.59 78.37, -7.32 in-out-out SNCioo out-out ActLoopNT-out 12.0232 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -48.66, 142.89 APE9-dihe-in -137.31, 146.9 APE8-dihe-in -83.8, 68.09 APE8-rot-na 31.86 APE67-dihe-in -70.2, -9.5 -48.58, -42.33 APE12-dist-na 13.3986 APE11-dist-na 16.8491 APE10-dist-na 14.8369 APE9-dist-out 8.2536 None None None XRAY 1.784 0.184 0.214 B 282.0 273.0 3 29 26 3 [[422, 678]] 1.0 6yq1 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1C Q05397 412 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.5807 15.8409 None -75.66, -177.24 -55.77, 133.76 -67.84, -41.72 295.72, 176.78 -60.36, -44.8 in-in in 7.6154 Saltbr-in 2.8575 HRD-in -71.08, -53.73 81.02, -10.73 in-out-out SNCioo out-out ActLoopNT-out 10.6328 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -15.64 APE9-dihe-in -96.3, 121.87 APE8-dihe-in -82.84, 65.74 APE8-rot-na 33.11 APE67-dihe-in -65.58, -12.51 -46.04, -44.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.9889 APE9-dist-out 8.8324 None None None XRAY 1.784 0.184 0.214 C 282.0 264.0 11 29 18 11 [[422, 678]] 1.0 6yq1 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YQ1D Q05397 415 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.6569 15.854 None -76.76, -177.88 -55.33, 133.74 -70.22, -39.58 296.95, 175.58 -62.46, -41.81 in-in in 7.5231 Saltbr-in 2.8813 HRD-in -70.74, -53.46 79.06, -11.18 in-out-out SNCioo out-out ActLoopNT-out 11.8128 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -83.88, 65.98 APE8-rot-na 32.0 APE67-dihe-in -68.39, -9.16 -46.59, -43.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4303 None None None XRAY 1.784 0.184 0.214 D 282.0 258.0 14 29 15 14 [[422, 678]] 1.0 6yq1 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9A Q05397 415 686 1052.0 P9K:701 Type1 Inactive DFGin 6.6927 15.6561 None -72.52, -178.45 -57.73, 135.79 -72.85, -37.79 298.07, 168.43 -63.0, -44.27 in-in in 7.5374 Saltbr-in 2.7557 HRD-in -68.47, -56.13 84.19, -11.31 in-out-out SNCioo out-out ActLoopNT-out 11.9709 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.92 APE8-dihe-in -80.86, 65.41 APE8-rot-na 32.51 APE67-dihe-in -65.96, -9.35 -56.05, -39.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8068 None None None XRAY 1.925 0.193 0.218 A 282.0 260.0 12 29 17 12 [[422, 678]] 1.0 6yr9 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9B Q05397 414 684 1052.0 P9K:701 Type1 Inactive DFGin 6.5412 15.688 None -72.19, -175.35 -58.86, 135.81 -72.29, -35.25 299.46, 167.83 -65.13, -41.68 in-in in 7.4869 Saltbr-in 2.81 HRD-in -74.4, -54.18 84.68, -14.66 in-out-out SNCioo out-out ActLoopNT-out 10.6014 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -51.93 APE9-dihe-in -104.69, 112.5 APE8-dihe-in -81.62, 64.47 APE8-rot-na 30.93 APE67-dihe-in -65.67, -8.67 -53.83, -41.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.4458 APE9-dist-out 8.9872 None None None XRAY 1.925 0.193 0.218 B 282.0 258.0 13 29 16 13 [[422, 678]] 1.0 6yr9 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9C Q05397 414 686 1052.0 P9K:701 Type1 Inactive DFGin 6.7066 15.6963 None -74.62, -175.14 -58.39, 136.31 -73.32, -36.06 298.17, 169.43 -64.54, -38.88 in-in in 7.4756 Saltbr-in 2.8023 HRD-in -67.84, -54.81 84.4, -10.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.96 APE8-dihe-in -83.91, 65.47 APE8-rot-na 32.43 APE67-dihe-in -66.56, -9.09 -55.03, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5794 None None None XRAY 1.925 0.193 0.218 C 282.0 258.0 15 29 14 15 [[422, 678]] 1.0 6yr9 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YR9D Q05397 412 685 1052.0 P9K:701 Type1 Inactive DFGin 6.8495 15.8997 None -73.97, -177.5 -59.32, 135.48 -74.09, -34.16 299.25, 167.14 -64.12, -40.48 in-in in 7.4832 Saltbr-in 2.8033 HRD-in -67.32, -56.9 82.13, -9.82 in-out-out SNCioo out-out ActLoopNT-out 11.9249 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.57 APE8-dihe-in -85.42, 67.52 APE8-rot-na 30.81 APE67-dihe-in -67.68, -8.19 -56.08, -39.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5104 None None None XRAY 1.925 0.193 0.218 D 282.0 262.0 12 29 17 12 [[422, 678]] 1.0 6yr9 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVSB Q05397 415 686 1052.0 PVT:701 Type1 Inactive DFGin 6.5709 16.0404 None -126.79, -3.83 -122.97, 123.34 -125.84, 999.0 281.41, 69.18 999.0, 999.0 in-in in 7.981 Saltbr-in 2.8944 HRD-in -66.74, -51.12 77.94, -4.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.44 APE8-dihe-in -83.24, 64.15 APE8-rot-na 28.78 APE67-dihe-in -64.0, -16.76 -48.41, -44.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1895 None None None XRAY 1.81 0.193 0.215 B 282.0 254.0 18 29 11 18 [[422, 678]] 1.0 6yvs Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVSD Q05397 412 686 1052.0 PVT:701 Type1 Inactive DFGin 7.1321 16.183 None -76.03, -175.56 -60.31, 138.69 -87.68, 999.0 305.08, 167.36 999.0, 999.0 in-in in 7.4899 Saltbr-in 2.7592 HRD-in -66.73, -51.22 77.37, -3.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.69 APE8-dihe-in -83.36, 63.72 APE8-rot-na 28.67 APE67-dihe-in -66.21, -12.54 -49.68, -44.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2983 None None None XRAY 1.81 0.193 0.215 D 282.0 257.0 18 29 11 18 [[422, 678]] 1.0 6yvs Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVYC Q05397 411 686 1052.0 P1E:802 Type1 Inactive DFGin 6.9905 16.3619 None -69.66, 178.7 -62.98, 133.91 -77.95, 999.0 300.74, 174.12 999.0, 999.0 in-in in 7.5264 Saltbr-in 2.7334 HRD-in -68.55, -50.55 78.07, -8.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.77 APE8-dihe-in -81.84, 60.78 APE8-rot-na 33.33 APE67-dihe-in -67.16, -11.03 -46.06, -44.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1877 None None None XRAY 1.918 0.215 0.235 C 282.0 258.0 18 29 11 18 [[422, 678]] 1.0 6yvy Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YVYD Q05397 415 686 1052.0 P1E:701 Type1 Inactive DFGin 7.055 14.8699 None -121.81, -169.66 55.51, 105.08 -131.24, 999.0 291.45, 85.32 999.0, 999.0 in-out in 7.9916 Saltbr-out 4.5329 HRD-in -68.69, -50.74 77.4, -7.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 145.59 APE9-dihe-in -72.33, 140.74 APE8-dihe-in -81.37, 62.58 APE8-rot-na 30.99 APE67-dihe-in -64.82, -12.74 -48.02, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3029 None None None XRAY 1.918 0.215 0.235 D 282.0 255.0 17 29 12 17 [[422, 678]] 1.0 6yvy Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVA Q05397 414 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.7802 15.896 None -74.38, 172.96 -50.5, 132.87 -70.58, -33.64 295.92, 176.86 -68.7, -41.79 in-in in 7.5061 Saltbr-in 2.7399 HRD-in -63.96, -44.94 72.24, 2.92 in-out-out SNCioo out-out ActLoopNT-out 11.9579 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.63 APE8-dihe-in -85.47, 62.62 APE8-rot-na 31.57 APE67-dihe-in -70.39, -3.07 -47.35, -41.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2994 None None None XRAY 2.298 0.203 0.232 A 282.0 261.0 12 29 17 12 [[422, 678]] 1.0 6yxv Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVB Q05397 415 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.7497 15.9158 None -75.08, 173.66 -51.87, 131.63 -68.87, -32.97 295.29, 177.69 -68.78, -48.08 in-in in 7.6569 Saltbr-in 2.7407 HRD-in -62.92, -46.64 75.37, -2.33 in-out-out SNCioo out-out ActLoopNT-out 11.9776 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.82 APE8-dihe-in -86.78, 62.62 APE8-rot-na 30.42 APE67-dihe-in -70.82, -2.85 -47.09, -41.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.187 None None None XRAY 2.298 0.203 0.232 B 282.0 260.0 12 29 17 12 [[422, 678]] 1.0 6yxv Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVC Q05397 414 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.8997 16.0318 None -74.5, 172.75 -51.5, 132.3 -71.72, -29.34 296.05, 175.78 -71.46, -48.84 in-in in 7.5013 Saltbr-in 2.7429 HRD-in -62.86, -46.42 73.82, -1.43 in-out-out SNCioo out-out ActLoopNT-out 12.0766 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -77.88, 152.47 APE9-dihe-in -135.02, 147.01 APE8-dihe-in -86.57, 63.93 APE8-rot-na 30.34 APE67-dihe-in -70.64, -1.8 -47.53, -42.32 APE12-dist-na 999.0 APE11-dist-na 16.304 APE10-dist-na 14.5361 APE9-dist-out 8.2347 None None None XRAY 2.298 0.203 0.232 C 282.0 265.0 8 29 21 8 [[422, 678]] 1.0 6yxv Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 6YXVD Q05397 415 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.5466 15.9097 None -69.88, 170.62 -49.04, 129.98 -64.73, -39.06 297.56, 170.69 -61.08, -44.2 in-in in 7.6236 Saltbr-in 2.7725 HRD-in -62.37, -45.76 74.99, -1.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.03 APE8-dihe-in -85.67, 62.63 APE8-rot-na 30.22 APE67-dihe-in -70.22, -2.35 -46.36, -42.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3226 None None None XRAY 2.298 0.203 0.232 D 282.0 257.0 15 29 14 15 [[422, 678]] 1.0 6yxv Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2B FAK2_HUMAN 3FZOA Q14289 420 691 1009.0 No_ligand No_ligand Inactive DFGin 7.0411 16.6484 None -80.41, -161.53 -55.79, 145.03 -57.19, 149.81 278.1, 79.23 -63.36, 124.08 in-out in 8.6788 Saltbr-out 3.9901 HRD-in -88.56, -44.48 71.73, -1.23 out-out-out SNCooo out-out ActLoopNT-out 7.2159 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.21 APE8-dihe-in -78.85, 65.44 APE8-rot-na 30.29 APE67-dihe-in -67.97, -12.51 -51.67, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2021 None None None XRAY 2.2 0.207 0.265 A 277.0 262.0 10 29 19 10 [[425, 681]] 1.0 3fzo Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 8YGXA Q14289 420 691 1009.0 No_ligand No_ligand Inactive DFGin 7.3395 16.9549 None -81.04, -163.09 -79.3, 167.03 -64.4, 154.66 279.14, 72.36 -77.31, 999.0 in-out in 9.6398 Saltbr-out 9.5712 HRD-in -87.71, -52.71 73.64, 6.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 156.88 APE8-dihe-in -79.69, 73.24 APE8-rot-na 32.8 APE67-dihe-in -69.65, -12.51 -56.52, -42.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1124 None None None XRAY 2.0 0.209 0.27 A 277.0 255.0 17 29 12 17 [[425, 681]] 1.0 8ygx Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 3CC6A Q14289 415 692 1009.0 No_ligand No_ligand Inactive DFGin 7.0032 16.5591 None -87.76, -163.7 -58.23, 148.28 -56.0, 147.59 284.53, 73.73 -57.12, 131.04 in-in in 8.8937 Saltbr-in 3.5112 HRD-in -90.62, -51.5 76.85, -2.02 in-out-out SNCioo out-out ActLoopNT-out 7.4363 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 61.77, 49.9 APE9-dihe-in -65.83, 147.14 APE8-dihe-in -78.84, 67.36 APE8-rot-na 28.85 APE67-dihe-in -70.52, -9.23 -47.7, -42.04 APE12-dist-na 14.4486 APE11-dist-na 8.5486 APE10-dist-na 10.5072 APE9-dist-out 8.2152 None None None XRAY 1.6 0.187 0.219 A 281.0 269.0 9 29 20 9 [[425, 681]] 1.0 3cc6 Homo sapiens TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 8XOXA Q14289 417 692 1009.0 YAM:701 Type1 Inactive DFGin 6.9505 16.4086 None -80.09, -162.96 -67.92, 153.8 -59.81, 149.69 281.78, 71.56 -67.49, 135.35 in-out in 9.5056 Saltbr-out 8.7294 HRD-in -84.67, -50.29 73.68, 0.48 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.93 APE8-dihe-in -79.37, 59.37 APE8-rot-na 36.03 APE67-dihe-in -77.94, -4.55 -50.42, -39.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3588 None None None XRAY 1.9 0.172 0.23 A 277.0 261.0 15 29 14 15 [[425, 681]] 1.0 8xox Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 5TOBA Q14289 420 690 1009.0 YAM:701 Type1 Inactive DFGin 6.6239 15.8925 None -80.12, -169.51 -62.87, 163.32 -68.81, 156.27 288.67, 73.8 -89.77, 999.0 in-none in 9.4038 Saltbr-none 999.0 HRD-in -91.14, -46.46 78.7, -8.23 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 58.94 APE8-rot-na 29.17 APE67-dihe-in -80.81, -3.79 -54.7, -37.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.117 0.212 0.262 A 282.0 245.0 26 29 11 18 [[425, 681]] 1.0 5tob Homo sapiens TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
TYR ROS1 ROS1_HUMAN 7Z5WA P08922 1937 2225 2347.0 IDW:2301 Type1 Inactive DFGin 6.695 14.3208 None -94.7, -152.87 -20.72, 134.4 -104.55, 141.7 300.47, 74.83 -69.24, 999.0 in-out in 7.9518 Saltbr-out 4.6104 HRD-in -58.16, -44.63 77.6, -17.37 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.24 APE8-dihe-in -84.74, 70.79 APE8-rot-na 30.54 APE67-dihe-in -61.34, -19.9 -51.55, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5582 None None None XRAY 2.254 0.226 0.276 A 331.0 271.0 18 30 12 18 [[1945, 2217]] 1.0 7z5w Homo sapiens TYR_ROS1_HUMAN TYR 6e-95 323.4 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5WB P08922 1937 2226 2347.0 IDW:2301 Type1 Inactive DFGin 6.8361 14.2683 None -118.79, -153.42 52.77, -75.92 69.95, 35.45 304.69, 93.82 -135.83, 999.0 in-out in 7.9597 Saltbr-out 5.1038 HRD-in -71.29, -42.41 71.74, -4.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.77 APE8-dihe-in -83.18, 59.59 APE8-rot-na 31.32 APE67-dihe-in -66.39, -14.66 -46.18, -41.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8303 None None None XRAY 2.254 0.226 0.276 B 331.0 272.0 18 30 12 18 [[1945, 2217]] 1.0 7z5w Homo sapiens TYR_ROS1_HUMAN TYR 6e-95 323.4 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5XA P08922 1937 2225 2347.0 AWJ:2301 Type1 Inactive DFGin 7.1398 14.3259 None -115.65, -151.87 19.28, 91.72 -103.73, 999.0 300.69, 79.11 999.0, 999.0 in-in in 7.8876 Saltbr-in 3.0105 HRD-in -78.13, -45.97 75.44, -15.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.49 APE8-dihe-in -89.41, 63.11 APE8-rot-na 11.43 APE67-dihe-in -63.61, -20.18 -48.49, -41.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6377 None None None XRAY 2.035 0.229 0.266 A 331.0 270.0 19 30 11 19 [[1945, 2217]] 1.0 7z5x Homo sapiens TYR_ROS1_HUMAN TYR 6e-95 323.4 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 7Z5XB P08922 1937 2226 2347.0 AWJ:2301 Type1 Inactive DFGin 7.1504 14.3759 None -105.58, -155.45 22.98, 111.73 -123.72, 999.0 298.95, 81.3 999.0, 999.0 in-in in 7.8715 Saltbr-in 3.0051 HRD-in -72.3, -46.74 74.95, -14.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.07 APE8-dihe-in -86.07, 63.61 APE8-rot-na 10.54 APE67-dihe-in -63.94, -20.45 -49.44, -39.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6733 None None None XRAY 2.035 0.229 0.266 B 331.0 271.0 19 30 11 19 [[1945, 2217]] 1.0 7z5x Homo sapiens TYR_ROS1_HUMAN TYR 6e-95 323.4 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR ROS1 ROS1_HUMAN 9QEKA P08922 1934 2229 2347.0 A1I6Z:62302 Type1 Inactive DFGin 6.4192 14.2358 None -128.5, -154.51 48.35, 74.6 -100.28, 999.0 297.06, 101.75 999.0, 999.0 in-out in 7.9577 Saltbr-out 4.5376 HRD-in -77.5, -45.64 72.03, 12.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 125.32 APE9-dihe-in -104.47, 106.45 APE8-dihe-in -80.98, 70.72 APE8-rot-na 35.17 APE67-dihe-in -71.98, -20.47 -66.89, -32.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3264 G2032R None None XRAY 2.205 0.203 0.272 A 301.0 274.0 22 30 12 18 [[1945, 2217]] 1.0 9qek Homo sapiens TYR_ROS1_HUMAN TYR 2.3e-93 318.2 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
TYR RYK RYK_HUMAN 6TUAA P34925 298 607 607.0 No_ligand No_ligand Inactive DFGin 10.422 12.8169 None -111.35, 168.38 -65.12, 162.3 -99.64, 13.64 76.36, 144.56 -58.39, 128.02 in-out in 9.6672 Saltbr-out 7.7988 HRD-in -75.74, -45.14 73.26, -4.48 out-out-in SNCooi out-in ActLoopNT-out 15.1476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.79, 98.06 APE9-dihe-in -120.22, 150.53 APE8-dihe-in -77.84, 63.77 APE8-rot-na 29.73 APE67-dihe-in -74.25, -12.88 -52.81, -38.05 APE12-dist-na 999.0 APE11-dist-na 15.6489 APE10-dist-na 11.4308 APE9-dist-in 7.5421 None None None XRAY 2.38 0.197 0.248 A 317.0 294.0 9 30 27 3 [[330, 598]] 1.0 6tua Homo sapiens TYR_RYK_HUMAN TYR 9.9e-80 273.5 1.0 260.0 260.0 482 483 484 486 488 364 381 385 462 464 463 465.0 524 512 507 506 505 504 503 502 501 412 Tyrosine-protein kinase RYK
TYR SRC SRC_HUMAN 8HAQA P12931 260 536 536.0 L1N:60601 Type1 Inactive DFGin 7.4752 16.4948 None -144.71, -178.06 51.15, 59.96 -68.83, 999.0 277.81, 75.52 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -79.23, -51.06 84.94, -13.72 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.15 APE8-rot-na 32.35 APE67-dihe-in -66.25, -16.22 -57.53, -32.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.209 0.25 A 277.0 247.0 30 29 10 19 [[270, 521]] 1.0 8haq Homo sapiens TYR_SRC_HUMAN TYR 1.4e-94 322.1 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 8JF3B P12931 261 536 536.0 C0N:601 Type1 Inactive DFGin 7.1348 16.0627 None -135.82, -168.85 67.82, -93.47 69.27, 999.0 290.66, 103.97 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -92.02, -35.42 67.06, 3.83 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.11 APE8-rot-na 10.82 APE67-dihe-in -68.72, -22.89 -67.01, -25.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.846 0.278 0.317 B 283.0 238.0 38 29 10 19 [[270, 521]] 1.0 8jf3 Homo sapiens TYR_SRC_HUMAN TYR 1.5e-94 322.0 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 1YOMB P12931 258 536 536.0 P01:60002 Type1 Inactive DFGin 7.1447 15.9556 None -150.45, -153.06 39.29, 44.85 -55.46, 999.0 262.87, 79.79 999.0, 999.0 in-none in 7.3529 Saltbr-none 999.0 HRD-in -98.52, -48.38 85.73, -24.58 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.01 APE8-dihe-out -94.51, 44.94 APE8-rot-na 35.15 APE67-dihe-in -62.96, -31.73 -55.8, -34.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5153 S345N,A370S,Y419W None None XRAY 2.9 0.222 0.313 B 283.0 261.0 18 29 11 18 [[270, 521]] 1.0 1yom Homo sapiens TYR_SRC_HUMAN TYR 1.9e-93 318.4 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR TNK2 ACK1_HUMAN 8HMTD Q07912 117 389 1038.0 LWX:401 Type1.5_Back Inactive DFGin 6.3063 13.3328 None -101.89, -122.34 -52.57, 148.88 -124.51, 20.24 302.36, 99.89 -60.05, -38.85 in-out in 8.5635 Saltbr-out 3.702 HRD-in -85.57, -47.32 68.53, 3.51 out-in-in SNCoii in-in ActLoopNT-in 3.0608 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.15, 128.97 APE9-dihe-in -122.52, 150.9 APE8-dihe-in -68.07, 94.15 APE8-rot-na 328.13 APE67-dihe-in -58.59, -46.12 -66.12, -27.69 APE12-dist-na 12.502 APE11-dist-na 7.8076 APE10-dist-na 10.8535 APE9-dist-in 5.8558 None None None XRAY 3.17 0.209 0.264 D 273.0 262.0 11 31 31 0 [[126, 387]] 1.0 8hmt Homo sapiens TYR_TNK2_HUMAN TYR 7.1e-86 293.6 1.0 259.0 259.0 269 270 271 273 275 158 177 181 249 251 250 252.0 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
TYR TYK2-1 TYK2_HUMAN 5C03A P29597 579 869 1187.0 AGS:901 ATPlike Pseudo DFGin 7.3841 13.1047 None -83.93, 173.19 -65.21, 161.12 -79.17, -4.85 20.2, 153.73 66.68, -148.85 in-na in 9.7941 Saltbr-na 999.0 HRD-in -90.34, -65.69 85.25, 3.79 na-out-out SNCaoo out-out ActLoopNT-out 7.8327 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.44, -38.84 APE9-dihe-out -63.06, -21.54 APE8-dihe-out -87.7, -1.06 APE8-rot-na 196.81 APE67-dihe-out -97.84, 8.94 -69.26, 133.75 APE12-dist-na 10.117 APE11-dist-na 12.2506 APE10-dist-na 16.4571 APE9-dist-out 11.202 None None None XRAY 1.9 0.183 0.218 A 342.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 5c03 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C03B P29597 580 870 1187.0 AGS:901 ATPlike Pseudo DFGin 7.5169 12.8858 None -71.74, 164.11 -66.43, 161.04 -81.86, 0.59 24.73, 148.49 67.14, -147.92 in-na in 9.7089 Saltbr-na 999.0 HRD-in -90.78, -63.58 88.98, 2.52 na-out-out SNCaoo out-out ActLoopNT-out 7.9567 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.24, -42.55 APE9-dihe-out -56.38, -27.94 APE8-dihe-out -85.13, -4.16 APE8-rot-na 194.3 APE67-dihe-out -97.21, 10.32 -66.64, 134.88 APE12-dist-na 9.6347 APE11-dist-na 12.3036 APE10-dist-na 16.4844 APE9-dist-out 11.2214 None None None XRAY 1.9 0.183 0.218 B 342.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 5c03 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4A P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.5069 12.8047 None -76.81, 166.44 -58.43, 152.23 -70.05, -8.8 24.77, 146.14 76.34, -154.15 in-na in 9.5557 Saltbr-na 999.0 HRD-in -86.69, -61.89 82.12, 4.68 na-out-out SNCaoo out-out ActLoopNT-out 8.2321 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.65, -45.17 APE9-dihe-out -58.59, -27.02 APE8-dihe-out -78.56, -9.63 APE8-rot-na 222.71 APE67-dihe-out -95.98, 6.87 -68.07, 131.63 APE12-dist-na 9.6622 APE11-dist-na 12.2836 APE10-dist-na 16.4637 APE9-dist-out 11.658 None None None XRAY 2.12 0.186 0.229 A 295.0 261.0 29 24 24 0 [[589, 868], [897, 1171]] 2.0 7ax4 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4B P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.4876 12.7756 None -74.88, 165.0 -57.44, 152.12 -71.28, -8.27 25.03, 145.7 75.91, -154.77 in-na in 9.4964 Saltbr-na 999.0 HRD-in -85.26, -61.54 83.16, 3.63 na-out-out SNCaoo out-out ActLoopNT-out 8.3251 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.51, -41.43 APE9-dihe-out -63.74, -26.18 APE8-dihe-out -77.76, -6.82 APE8-rot-na 221.04 APE67-dihe-out -90.97, 8.23 -71.21, 136.1 APE12-dist-na 9.8072 APE11-dist-na 12.3205 APE10-dist-na 16.5418 APE9-dist-out 11.7928 None None None XRAY 2.12 0.186 0.229 B 295.0 261.0 29 24 24 0 [[589, 868], [897, 1171]] 2.0 7ax4 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98A P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.3534 12.6977 None -63.41, 150.46 -40.02, 136.95 -69.11, -5.37 28.88, 139.25 79.24, -154.61 in-na in 9.6761 Saltbr-na 999.0 HRD-in -86.71, -58.07 85.92, 3.99 na-out-out SNCaoo out-out ActLoopNT-out 8.1152 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.34, -41.36 APE9-dihe-out -63.27, -26.83 APE8-dihe-out -87.06, 1.76 APE8-rot-na 289.42 APE67-dihe-out -101.27, 10.15 -70.05, 135.5 APE12-dist-na 9.7695 APE11-dist-na 12.3681 APE10-dist-na 16.5009 APE9-dist-out 11.6332 None None CSO808 XRAY 1.87 0.226 0.274 A 295.0 256.0 35 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98B P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.3388 12.942 None -54.77, 156.29 -53.9, 146.74 -74.48, -2.14 30.11, 138.2 66.75, -149.92 in-na in 9.6961 Saltbr-na 999.0 HRD-in -77.0, -58.39 85.56, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.4655 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.92, -37.3 APE9-dihe-out -60.59, -30.35 APE8-dihe-out -84.45, -1.45 APE8-rot-na 293.47 APE67-dihe-out -99.24, 10.29 -63.77, 131.59 APE12-dist-na 9.9673 APE11-dist-na 12.261 APE10-dist-na 16.5394 APE9-dist-out 11.7384 None None CSO808 XRAY 1.87 0.226 0.274 B 295.0 259.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98C P29597 578 868 1187.0 ZRU:901 Type1 Pseudo DFGin 7.5577 12.8193 None -59.14, 154.57 -51.18, 142.9 -77.73, 6.11 31.51, 139.73 67.49, -158.75 in-na in 9.6147 Saltbr-na 999.0 HRD-in -81.52, -60.95 90.44, 9.6 na-out-out SNCaoo out-out ActLoopNT-out 8.5721 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.87, -38.56 APE9-dihe-out -63.68, -27.1 APE8-dihe-out -84.04, -1.3 APE8-rot-na 288.57 APE67-dihe-out -98.82, 11.75 -65.96, 135.63 APE12-dist-na 9.9318 APE11-dist-na 12.2766 APE10-dist-na 16.5124 APE9-dist-out 11.8618 None None CSO808 XRAY 1.87 0.226 0.274 C 295.0 261.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99A P29597 578 868 1187.0 ZS3:901 Type1 Pseudo DFGin 7.3994 12.7822 None -62.82, 155.3 -51.38, 147.9 -74.24, -0.55 28.63, 142.53 65.17, -151.12 in-na in 9.6586 Saltbr-na 999.0 HRD-in -82.17, -60.98 83.64, 7.23 na-out-out SNCaoo out-out ActLoopNT-out 8.3299 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -38.21 APE9-dihe-out -59.13, -29.8 APE8-dihe-out -88.76, 1.4 APE8-rot-na 298.32 APE67-dihe-out -97.29, 12.8 -68.06, 135.28 APE12-dist-na 9.9277 APE11-dist-na 12.29 APE10-dist-na 16.5863 APE9-dist-out 11.7615 None None None XRAY 1.71 0.191 0.225 A 295.0 261.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99B P29597 579 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.4426 12.6145 None -56.5, 153.96 -51.89, 147.7 -74.35, -1.31 29.46, 140.64 65.58, -151.37 in-na in 9.5567 Saltbr-na 999.0 HRD-in -80.48, -58.61 84.39, 4.19 na-out-out SNCaoo out-out ActLoopNT-out 8.4257 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.04, -40.63 APE9-dihe-out -58.98, -25.02 APE8-dihe-out -89.21, 1.32 APE8-rot-na 294.34 APE67-dihe-out -101.31, 17.67 -66.15, 136.61 APE12-dist-na 9.9093 APE11-dist-na 12.1858 APE10-dist-na 16.4711 APE9-dist-out 11.849 None None None XRAY 1.71 0.191 0.225 B 295.0 261.0 29 24 24 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99C P29597 578 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.4621 12.589 None -61.71, 157.01 -52.78, 147.81 -73.85, -0.24 30.37, 137.25 70.68, -153.5 in-na in 9.5877 Saltbr-na 999.0 HRD-in -82.08, -63.18 88.21, 6.86 na-out-out SNCaoo out-out ActLoopNT-out 8.1733 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.66, -43.16 APE9-dihe-out -54.27, -29.75 APE8-dihe-out -91.84, 3.24 APE8-rot-na 295.26 APE67-dihe-out -102.57, 13.29 -66.4, 134.15 APE12-dist-na 9.7375 APE11-dist-na 12.4322 APE10-dist-na 16.5442 APE9-dist-out 11.6845 None None None XRAY 1.71 0.191 0.225 C 295.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AA P29597 577 868 1187.0 ZSB:901 Type1 Pseudo DFGin 7.4645 12.7833 None -59.49, 156.87 -53.44, 145.49 -73.94, -3.93 28.08, 142.08 71.29, -152.49 in-na in 9.6449 Saltbr-na 999.0 HRD-in -80.97, -57.69 81.03, 6.24 na-out-out SNCaoo out-out ActLoopNT-out 8.4683 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.12, -39.62 APE9-dihe-out -57.45, -31.53 APE8-dihe-out -85.9, -0.44 APE8-rot-na 294.43 APE67-dihe-out -98.22, 12.4 -65.02, 133.34 APE12-dist-na 9.9666 APE11-dist-na 12.2854 APE10-dist-na 16.6055 APE9-dist-out 11.8385 None None None XRAY 1.83 0.186 0.224 A 295.0 264.0 28 24 24 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AB P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.5488 12.6065 None -55.02, 155.39 -55.48, 149.15 -78.11, 1.0 33.17, 138.7 68.16, -152.66 in-na in 9.568 Saltbr-na 999.0 HRD-in -83.23, -60.75 91.28, -0.48 na-out-out SNCaoo out-out ActLoopNT-out 8.591 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.5, -42.74 APE9-dihe-out -57.15, -27.18 APE8-dihe-out -83.95, -1.9 APE8-rot-na 289.14 APE67-dihe-out -98.17, 15.26 -66.86, 137.45 APE12-dist-na 9.96 APE11-dist-na 12.0778 APE10-dist-na 16.4122 APE9-dist-out 11.8945 None None None XRAY 1.83 0.186 0.224 B 295.0 263.0 28 24 24 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AC P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.4518 12.6679 None -61.15, 155.8 -50.19, 148.71 -74.89, -0.44 30.12, 140.82 66.87, -150.05 in-na in 9.6545 Saltbr-na 999.0 HRD-in -81.68, -62.05 88.29, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.2603 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.23, -43.49 APE9-dihe-out -60.0, -25.56 APE8-dihe-out -89.19, -0.15 APE8-rot-na 289.26 APE67-dihe-out -98.71, 15.21 -67.33, 135.82 APE12-dist-na 9.6965 APE11-dist-na 12.3095 APE10-dist-na 16.4937 APE9-dist-out 11.7664 None None None XRAY 1.83 0.186 0.224 C 295.0 261.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDA P29597 581 866 1187.0 7GL:901 Type1 Pseudo DFGin 7.5132 12.6298 None -67.32, 165.44 -61.21, 150.11 -77.85, 2.5 30.62, 144.39 70.23, -152.17 in-na in 9.487 Saltbr-na 999.0 HRD-in -86.12, -60.06 82.4, 7.11 na-out-out SNCaoo out-out ActLoopNT-out 8.1629 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.41, -39.74 APE9-dihe-out -61.67, -21.18 APE8-dihe-out -86.78, -7.05 APE8-rot-na 289.65 APE67-dihe-out -93.06, 5.59 -69.25, 133.26 APE12-dist-na 9.6904 APE11-dist-na 12.2198 APE10-dist-na 16.4057 APE9-dist-out 11.5781 None None None XRAY 1.92 0.193 0.215 A 298.0 248.0 40 24 24 0 [[589, 868], [897, 1171]] 2.0 5tkd Homo sapiens TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDB P29597 581 867 1187.0 7GL:901 Type1 Pseudo DFGin 7.5338 12.4894 None -66.93, 165.19 -61.5, 149.63 -77.96, 1.32 30.48, 144.44 72.41, -154.16 in-na in 9.4218 Saltbr-na 999.0 HRD-in -86.72, -59.64 79.99, 10.31 na-out-out SNCaoo out-out ActLoopNT-out 8.0292 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.45, -40.77 APE9-dihe-out -60.64, -23.02 APE8-dihe-out -86.44, -3.61 APE8-rot-na 200.95 APE67-dihe-out -92.39, 6.26 -73.47, 133.63 APE12-dist-na 9.6657 APE11-dist-na 12.184 APE10-dist-na 16.3806 APE9-dist-out 11.4573 None None None XRAY 1.92 0.193 0.215 B 298.0 247.0 41 24 24 0 [[589, 868], [897, 1171]] 2.0 5tkd Homo sapiens TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 3ZONA P29597 577 870 1187.0 IK1:1871 Type1 Pseudo DFGin 7.3684 12.7622 None -83.03, 173.2 -63.77, 153.55 -76.54, -5.77 26.47, 146.49 67.78, -154.99 in-na in 9.6551 Saltbr-na 999.0 HRD-in -77.23, -57.87 87.41, -1.46 na-out-out SNCaoo out-out ActLoopNT-out 8.3603 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.01, -48.69 APE9-dihe-out -50.14, -31.16 APE8-dihe-out -81.83, -2.56 APE8-rot-na 292.76 APE67-dihe-out -91.8, 2.07 -66.27, 133.13 APE12-dist-na 10.153 APE11-dist-na 12.3104 APE10-dist-na 16.6205 APE9-dist-out 11.9768 None None None XRAY 2.15 0.217 0.268 A 335.0 261.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 3zon Homo sapiens TYR_TYK2-1_HUMAN TYR 6.5e-60 208.7 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRA P29597 578 867 1187.0 LAJ:901 Type1 Pseudo DFGin 7.7767 12.7807 None -69.45, 168.07 -65.99, 154.27 -73.6, -4.41 23.84, 151.16 77.17, -140.45 in-na in 9.4351 Saltbr-na 999.0 HRD-in -82.75, -62.0 89.42, -4.52 na-out-out SNCaoo out-out ActLoopNT-out 8.0946 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.36, -40.74 APE9-dihe-out -63.5, -26.3 APE8-dihe-out -83.27, -1.28 APE8-rot-na 205.99 APE67-dihe-out -86.49, -0.68 -74.39, 134.15 APE12-dist-na 9.7117 APE11-dist-na 12.1953 APE10-dist-na 16.3588 APE9-dist-out 11.5527 None None None XRAY 2.56 0.19 0.229 A 317.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzr Homo sapiens TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRB P29597 580 868 1187.0 LAJ:901 Type1 Pseudo DFGin 7.7942 12.7348 None -69.51, 167.49 -66.18, 155.4 -74.3, -4.56 23.99, 151.21 77.6, -139.58 in-na in 9.3707 Saltbr-na 999.0 HRD-in -85.74, -61.72 89.77, -6.44 na-out-out SNCaoo out-out ActLoopNT-out 8.1637 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.72, -41.32 APE9-dihe-out -63.03, -22.95 APE8-dihe-out -84.92, -4.81 APE8-rot-na 227.24 APE67-dihe-out -86.54, 0.37 -71.84, 134.55 APE12-dist-na 9.7055 APE11-dist-na 12.2225 APE10-dist-na 16.3775 APE9-dist-out 11.5502 None None None XRAY 2.56 0.19 0.229 B 317.0 259.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzr Homo sapiens TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVA P29597 580 869 1187.0 3SM:901 Type1 Pseudo DFGin 7.414 12.6121 None -81.79, 172.74 -64.96, 152.2 -79.14, 3.8 29.41, 144.45 64.39, -148.74 in-na in 9.4339 Saltbr-na 999.0 HRD-in -91.37, -57.71 81.66, 1.38 na-out-out SNCaoo out-out ActLoopNT-out 8.4716 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.89, -40.33 APE9-dihe-out -59.96, -25.88 APE8-dihe-out -82.28, -6.26 APE8-rot-na 203.31 APE67-dihe-out -93.77, 1.64 -65.5, 131.41 APE12-dist-na 9.8652 APE11-dist-na 12.1551 APE10-dist-na 16.3727 APE9-dist-out 11.6198 None None None XRAY 1.8 0.193 0.214 A 317.0 258.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 4wov Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVB P29597 580 867 1187.0 3SM:901 Type1 Pseudo DFGin 7.3745 12.5637 None -82.96, 174.29 -64.97, 150.22 -78.54, 4.38 29.82, 144.02 64.16, -150.45 in-na in 9.3856 Saltbr-na 999.0 HRD-in -91.0, -57.11 81.71, 1.86 na-out-out SNCaoo out-out ActLoopNT-out 8.5397 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.69, -39.07 APE9-dihe-out -62.22, -22.21 APE8-dihe-out -86.45, -3.31 APE8-rot-na 190.55 APE67-dihe-out -96.7, 6.38 -71.04, 134.12 APE12-dist-na 9.8281 APE11-dist-na 12.1118 APE10-dist-na 16.3132 APE9-dist-out 11.6558 None None None XRAY 1.8 0.193 0.214 B 317.0 256.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 4wov Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLA P29597 581 866 1187.0 KZJ:901 Type1 Pseudo DFGin 7.4466 12.6266 None -65.67, 163.1 -59.9, 147.3 -72.43, 0.95 25.4, 149.24 71.0, -150.31 in-na in 9.4495 Saltbr-na 999.0 HRD-in -79.19, -61.15 86.61, -0.76 na-out-out SNCaoo out-out ActLoopNT-out 8.317 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.34, -39.28 APE9-dihe-out -63.02, -22.39 APE8-dihe-out -82.22, -10.35 APE8-rot-na 292.93 APE67-dihe-out -91.53, -2.04 -67.32, 133.05 APE12-dist-na 9.7215 APE11-dist-na 12.197 APE10-dist-na 16.4126 APE9-dist-out 11.6997 None None None XRAY 2.15 0.203 0.213 A 317.0 251.0 37 24 24 0 [[589, 868], [897, 1171]] 2.0 6nsl Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLB P29597 581 867 1187.0 KZJ:901 Type1 Pseudo DFGin 7.4662 12.5425 None -65.53, 162.68 -58.2, 146.74 -72.38, 1.37 25.74, 148.82 71.06, -152.3 in-na in 9.4228 Saltbr-na 999.0 HRD-in -80.39, -61.97 87.32, -2.61 na-out-out SNCaoo out-out ActLoopNT-out 8.2412 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.57, -38.38 APE9-dihe-out -63.64, -23.52 APE8-dihe-out -84.88, -4.11 APE8-rot-na 200.51 APE67-dihe-out -91.36, -1.36 -71.83, 133.14 APE12-dist-na 9.6668 APE11-dist-na 12.1774 APE10-dist-na 16.3911 APE9-dist-out 11.5683 None None None XRAY 2.15 0.203 0.213 B 317.0 248.0 40 24 24 0 [[589, 868], [897, 1171]] 2.0 6nsl Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEA P29597 581 863 1187.0 L8Y:901 Type1 Pseudo DFGin 7.5169 12.3274 None -67.15, 165.53 -62.27, 154.27 -78.2, -0.61 28.22, 144.21 70.11, -150.04 in-na in 9.308 Saltbr-na 999.0 HRD-in -90.68, -61.1 81.57, 5.39 na-out-out SNCaoo out-out ActLoopNT-out 8.1267 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.25, -36.4 APE9-dihe-out -64.18, -24.4 APE8-dihe-out -85.3, -4.22 APE8-rot-na 196.84 APE67-dihe-out -93.12, 7.25 -69.65, 135.35 APE12-dist-na 9.8139 APE11-dist-na 12.2409 APE10-dist-na 16.4577 APE9-dist-out 11.4388 None None None XRAY 1.96 0.197 0.227 A 317.0 250.0 38 24 24 0 [[589, 868], [897, 1171]] 2.0 6nze Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEB P29597 580 867 1187.0 L8Y:901 Type1 Pseudo DFGin 7.5096 12.3305 None -67.31, 165.25 -60.76, 154.35 -79.17, -0.55 28.55, 143.7 69.96, -145.72 in-na in 9.3364 Saltbr-na 999.0 HRD-in -88.53, -60.87 81.08, 6.03 na-out-out SNCaoo out-out ActLoopNT-out 8.0726 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.94, -35.62 APE9-dihe-out -64.8, -24.24 APE8-dihe-out -85.49, -3.91 APE8-rot-na 196.79 APE67-dihe-out -92.3, 6.8 -70.0, 135.83 APE12-dist-na 9.7323 APE11-dist-na 12.1508 APE10-dist-na 16.3803 APE9-dist-out 11.4163 None None None XRAY 1.96 0.197 0.227 B 317.0 254.0 35 24 24 0 [[589, 868], [897, 1171]] 2.0 6nze Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFA P29597 580 865 1187.0 L91:901 Type1 Pseudo DFGin 7.5997 12.6706 None -71.29, 168.26 -64.87, 155.03 -75.86, -3.47 25.03, 153.09 77.38, -149.91 in-na in 9.4012 Saltbr-na 999.0 HRD-in -80.34, -62.67 82.96, 5.24 na-out-out SNCaoo out-out ActLoopNT-out 8.0939 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.48, -39.01 APE9-dihe-out -62.83, -25.44 APE8-dihe-out -82.23, -7.85 APE8-rot-na 215.68 APE67-dihe-out -92.43, 5.04 -68.27, 132.64 APE12-dist-na 9.8083 APE11-dist-na 12.2624 APE10-dist-na 16.5169 APE9-dist-out 11.6235 None None None XRAY 2.39 0.205 0.231 A 317.0 247.0 42 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzf Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFB P29597 580 867 1187.0 L91:901 Type1 Pseudo DFGin 7.6703 12.5979 None -70.84, 168.4 -64.97, 153.82 -75.67, -2.7 25.33, 152.34 77.04, -149.81 in-na in 9.3721 Saltbr-na 999.0 HRD-in -81.43, -61.17 83.19, 3.8 na-out-out SNCaoo out-out ActLoopNT-out 8.1122 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.59, -38.89 APE9-dihe-out -62.81, -25.28 APE8-dihe-out -84.37, -2.23 APE8-rot-na 213.59 APE67-dihe-out -91.99, 5.73 -72.88, 133.85 APE12-dist-na 9.7519 APE11-dist-na 12.2295 APE10-dist-na 16.478 APE9-dist-out 11.5547 None None None XRAY 2.39 0.205 0.231 B 317.0 248.0 41 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzf Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHA P29597 581 866 1187.0 L9A:4000 Type1 Pseudo DFGin 7.4056 12.7716 None -62.74, 170.7 -72.48, 150.15 -70.83, -2.83 23.35, 152.01 73.55, -152.26 in-na in 9.497 Saltbr-na 999.0 HRD-in -83.24, -60.86 86.7, -4.43 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -35.12 APE9-dihe-out -65.62, -29.8 APE8-dihe-out -77.88, -5.55 APE8-rot-na 294.99 APE67-dihe-out -89.76, 4.67 -72.08, 133.72 APE12-dist-na 9.7747 APE11-dist-na 12.2293 APE10-dist-na 16.4702 APE9-dist-out 11.3169 None None None XRAY 2.73 0.193 0.215 A 317.0 249.0 39 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzh Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHB P29597 580 867 1187.0 L9A:4000 Type1 Pseudo DFGin 7.436 12.5992 None -60.73, 169.6 -71.23, 150.14 -70.46, -1.47 23.31, 151.91 71.77, -152.11 in-na in 9.3762 Saltbr-na 999.0 HRD-in -83.11, -60.28 86.79, -5.89 na-out-out SNCaoo out-out ActLoopNT-out 8.3079 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.38, -35.33 APE9-dihe-out -65.44, -29.63 APE8-dihe-out -78.49, -5.17 APE8-rot-na 295.66 APE67-dihe-out -89.42, 4.66 -71.76, 134.2 APE12-dist-na 9.7352 APE11-dist-na 12.2156 APE10-dist-na 16.4369 APE9-dist-out 11.2686 None None None XRAY 2.73 0.193 0.215 B 317.0 249.0 40 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzh Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPA P29597 580 869 1187.0 LB7:901 Type1 Pseudo DFGin 7.454 12.358 None -74.98, 168.42 -62.51, 146.95 -73.8, -0.03 29.8, 144.9 77.36, -162.45 in-na in 9.2156 Saltbr-na 999.0 HRD-in -77.18, -62.62 87.16, 3.67 na-out-out SNCaoo out-out ActLoopNT-out 8.3072 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.98, -44.81 APE9-dihe-out -54.69, -25.84 APE8-dihe-out -83.74, 2.24 APE8-rot-na 279.61 APE67-dihe-out -91.79, -3.26 -74.14, 129.81 APE12-dist-na 9.758 APE11-dist-na 11.986 APE10-dist-na 16.1538 APE9-dist-out 11.5549 None None None XRAY 2.35 0.191 0.238 A 317.0 259.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzp Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPB P29597 580 868 1187.0 LB7:901 Type1 Pseudo DFGin 7.4573 12.3775 None -74.39, 168.01 -61.52, 147.56 -74.66, 0.45 29.5, 145.4 75.25, -161.58 in-na in 9.2883 Saltbr-na 999.0 HRD-in -77.4, -62.3 87.31, 3.57 na-out-out SNCaoo out-out ActLoopNT-out 8.2471 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -56.49, -45.45 APE9-dihe-out -54.3, -24.89 APE8-dihe-out -83.35, -4.08 APE8-rot-na 280.62 APE67-dihe-out -91.28, -1.02 -71.12, 130.29 APE12-dist-na 9.7731 APE11-dist-na 12.02 APE10-dist-na 16.2103 APE9-dist-out 11.5561 None None None XRAY 2.35 0.191 0.238 B 317.0 260.0 29 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzp Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQA P29597 580 867 1187.0 LB4:4000 Type1 Pseudo DFGin 7.5041 12.4001 None -72.22, 171.6 -66.25, 148.31 -74.94, 3.34 30.76, 143.31 66.4, -168.53 in-na in 9.0385 Saltbr-na 999.0 HRD-in -79.47, -65.7 83.13, 11.6 na-out-out SNCaoo out-out ActLoopNT-out 8.4967 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.2, -35.07 APE9-dihe-out -63.1, -22.48 APE8-dihe-out -87.78, -5.31 APE8-rot-na 268.32 APE67-dihe-out -91.66, 0.19 -69.75, 131.87 APE12-dist-na 9.8813 APE11-dist-na 12.0917 APE10-dist-na 16.3683 APE9-dist-out 11.7203 None None None XRAY 2.11 0.199 0.237 A 317.0 256.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzq Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQB P29597 580 868 1187.0 LB4:4000 Type1 Pseudo DFGin 7.5519 12.3705 None -70.99, 170.41 -64.59, 148.83 -75.35, 4.18 30.96, 143.54 65.3, -166.93 in-na in 8.9581 Saltbr-na 999.0 HRD-in -80.49, -65.88 83.34, 10.69 na-out-out SNCaoo out-out ActLoopNT-out 8.4422 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.78, -35.63 APE9-dihe-out -62.43, -22.89 APE8-dihe-out -87.56, -5.29 APE8-rot-na 268.51 APE67-dihe-out -92.56, 0.73 -69.67, 131.53 APE12-dist-na 9.9105 APE11-dist-na 12.0885 APE10-dist-na 16.4392 APE9-dist-out 11.6943 None None None XRAY 2.11 0.199 0.237 B 317.0 258.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 6nzq Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OA P29597 580 867 1187.0 VZJ:901 Type1 Pseudo DFGin 7.3657 12.5647 None -66.43, 170.03 -67.36, 143.81 -70.91, 1.79 25.53, 145.85 78.47, -152.75 in-na in 9.2658 Saltbr-na 999.0 HRD-in -75.49, -66.33 85.17, 12.8 na-out-out SNCaoo out-out ActLoopNT-out 8.1813 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.32, -40.35 APE9-dihe-out -58.15, -35.87 APE8-dihe-out -71.09, -6.29 APE8-rot-na 289.01 APE67-dihe-out -84.78, -2.19 -73.46, 133.77 APE12-dist-na 9.7653 APE11-dist-na 12.0883 APE10-dist-na 16.2662 APE9-dist-out 11.7631 None None None XRAY 2.82 0.181 0.252 A 317.0 257.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 7k7o Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OB P29597 580 868 1187.0 VZJ:901 Type1 Pseudo DFGin 7.7233 12.2472 None -71.51, -175.68 -81.24, 151.01 -79.84, 4.8 35.04, 138.85 72.06, -152.96 in-na in 9.264 Saltbr-na 999.0 HRD-in -101.81, -60.3 88.52, -5.44 na-out-out SNCaoo out-out ActLoopNT-out 8.9231 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.95, -43.16 APE9-dihe-out -55.55, -22.53 APE8-dihe-out -85.45, 0.22 APE8-rot-na 226.83 APE67-dihe-out -83.49, -4.03 -76.46, 136.55 APE12-dist-na 9.6282 APE11-dist-na 12.1992 APE10-dist-na 16.2685 APE9-dist-out 11.2834 None None None XRAY 2.82 0.181 0.252 B 317.0 257.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 7k7o Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QA P29597 580 867 1187.0 VZG:901 Type1 Pseudo DFGin 7.5433 12.5328 None -69.2, 167.5 -63.98, 154.51 -77.3, 7.34 29.56, 146.11 63.89, -146.65 in-na in 9.2815 Saltbr-na 999.0 HRD-in -79.96, -60.41 88.18, -6.56 na-out-out SNCaoo out-out ActLoopNT-out 8.3981 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.8, -37.69 APE9-dihe-out -61.19, -23.02 APE8-dihe-out -86.96, -5.2 APE8-rot-na 283.59 APE67-dihe-out -89.93, 5.32 -68.44, 135.46 APE12-dist-na 9.8237 APE11-dist-na 12.1193 APE10-dist-na 16.4879 APE9-dist-out 11.8015 None None None XRAY 2.27 0.191 0.215 A 317.0 256.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 7k7q Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QB P29597 580 868 1187.0 VZG:901 Type1 Pseudo DFGin 7.5281 12.4836 None -69.63, 166.47 -62.41, 154.32 -76.74, 6.87 29.05, 146.64 63.93, -146.22 in-na in 9.2635 Saltbr-na 999.0 HRD-in -80.84, -60.47 88.54, -6.14 na-out-out SNCaoo out-out ActLoopNT-out 8.3869 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.52, -36.89 APE9-dihe-out -61.37, -23.14 APE8-dihe-out -89.62, -0.64 APE8-rot-na 285.2 APE67-dihe-out -89.84, 4.92 -69.09, 135.18 APE12-dist-na 9.7848 APE11-dist-na 12.1271 APE10-dist-na 16.4591 APE9-dist-out 11.7008 None None None XRAY 2.27 0.191 0.215 B 317.0 251.0 38 24 24 0 [[589, 868], [897, 1171]] 2.0 7k7q Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5A P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.5755 12.8276 None -72.9, 166.16 -62.82, 156.7 -75.2, -1.8 19.44, 155.05 65.85, -157.21 in-na in 9.6283 Saltbr-na 999.0 HRD-in -77.18, -55.68 90.86, -17.89 na-out-out SNCaoo out-out ActLoopNT-out 8.0333 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.91, -37.05 APE9-dihe-out -64.82, -24.45 APE8-dihe-out -87.22, -2.73 APE8-rot-na 294.55 APE67-dihe-out -99.67, 13.88 -62.74, 133.89 APE12-dist-na 9.9661 APE11-dist-na 12.452 APE10-dist-na 16.6371 APE9-dist-out 11.8185 None None None XRAY 2.32 0.187 0.243 A 326.0 257.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 8tb5 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5B P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.3538 12.8302 None -69.46, 162.15 -62.48, 155.25 -75.42, -2.04 28.22, 143.07 66.45, -159.8 in-na in 9.6545 Saltbr-na 999.0 HRD-in -80.42, -58.38 87.54, 2.75 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.71, -36.16 APE9-dihe-out -65.57, -18.78 APE8-dihe-out -89.43, 3.6 APE8-rot-na 301.67 APE67-dihe-out -95.11, 8.54 -67.3, 136.04 APE12-dist-na 10.0198 APE11-dist-na 12.281 APE10-dist-na 16.5002 APE9-dist-out 11.7261 None None None XRAY 2.32 0.187 0.243 B 326.0 257.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 8tb5 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6A P29597 572 869 1187.0 ZOI:901 Type1 Pseudo DFGin 7.5187 12.9175 None -70.48, 163.05 -64.31, 156.7 -77.96, 2.63 25.15, 152.72 70.88, -150.51 in-na in 9.7566 Saltbr-na 999.0 HRD-in -88.04, -58.25 80.3, 7.16 na-out-out SNCaoo out-out ActLoopNT-out 8.0054 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -38.13 APE9-dihe-out -58.13, -23.83 APE8-dihe-out -87.03, -4.8 APE8-rot-na 225.26 APE67-dihe-out -95.58, 10.52 -67.22, 136.28 APE12-dist-na 9.6696 APE11-dist-na 12.2145 APE10-dist-na 16.3433 APE9-dist-out 11.3389 None None None XRAY 1.96 0.195 0.236 A 326.0 263.0 33 24 24 0 [[589, 868], [897, 1171]] 2.0 8tb6 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6B P29597 580 867 1187.0 ZOI:901 Type1 Pseudo DFGin 7.5755 12.8341 None -75.19, 161.88 -63.62, 154.56 -77.31, 0.0 28.4, 144.85 69.85, -142.97 in-na in 9.7458 Saltbr-na 999.0 HRD-in -86.92, -60.13 92.81, -6.33 na-out-out SNCaoo out-out ActLoopNT-out 8.2289 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.54, -39.0 APE9-dihe-out -57.31, -25.9 APE8-dihe-out -87.7, -3.61 APE8-rot-na 309.71 APE67-dihe-out -99.75, 10.76 -63.68, 135.57 APE12-dist-na 9.794 APE11-dist-na 12.1163 APE10-dist-na 16.3342 APE9-dist-out 11.4309 None None None XRAY 1.96 0.195 0.236 B 326.0 254.0 35 24 24 0 [[589, 868], [897, 1171]] 2.0 8tb6 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01A P29597 580 868 1187.0 UNL:901 Type1 Pseudo DFGin 7.4943 12.9533 None -78.77, 168.17 -59.3, 158.84 -78.02, -0.56 29.95, 141.01 70.43, -143.96 in-na in 9.8598 Saltbr-na 999.0 HRD-in -88.89, -66.71 89.22, 5.88 na-out-out SNCaoo out-out ActLoopNT-out 8.0202 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.06, -43.56 APE9-dihe-out -60.5, -24.62 APE8-dihe-out -84.02, 0.04 APE8-rot-na 309.1 APE67-dihe-out -102.6, 18.85 -65.89, 133.72 APE12-dist-na 10.0346 APE11-dist-na 12.5583 APE10-dist-na 16.7146 APE9-dist-out 11.3483 None None None XRAY 2.15 0.197 0.24 A 342.0 258.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 5c01 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01B P29597 579 869 1187.0 UNL:901 Type1 Pseudo DFGin 7.503 12.9896 None -83.69, 167.93 -60.38, 156.97 -77.3, 1.6 26.16, 146.38 64.95, -141.34 in-na in 9.8461 Saltbr-na 999.0 HRD-in -91.02, -62.48 85.42, 13.36 na-out-out SNCaoo out-out ActLoopNT-out 8.0537 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.57, -43.79 APE9-dihe-out -56.12, -28.45 APE8-dihe-out -84.03, 3.14 APE8-rot-na 209.42 APE67-dihe-out -101.1, 17.13 -74.09, 134.94 APE12-dist-na 9.9892 APE11-dist-na 12.5924 APE10-dist-na 16.7381 APE9-dist-out 11.6359 None None None XRAY 2.15 0.197 0.24 B 342.0 260.0 31 24 24 0 [[589, 868], [897, 1171]] 2.0 5c01 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 4GIIA P29597 890 1176 1187.0 0X6:61201 Type1 Inactive DFGin 6.4923 13.9575 None -81.38, -98.04 -79.43, 140.5 -122.16, 30.13 291.74, 87.83 -62.78, -33.65 in-in in 8.2134 Saltbr-in 2.7437 HRD-in -76.73, -46.7 63.15, 9.59 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -89.05, 4.42 APE9-dihe-in -63.44, 130.54 APE8-dihe-in -78.88, 64.67 APE8-rot-na 24.5 APE67-dihe-in -75.7, -5.4 -49.65, -33.9 APE12-dist-na 9.9046 APE11-dist-na 13.0115 APE10-dist-na 9.594 APE9-dist-in 6.6565 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.31 0.221 0.252 A 302.0 287.0 0 31 31 0 [[589, 868], [897, 1171]] 2.0 4gii Homo sapiens TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TKL LYR4 G7K7K0_MEDTR 8PS7A G7K7K0 340 636 660.0 ANP:704 ATPlike Pseudo DFGin 7.3438 12.4911 None -132.7, -71.23 -80.99, 65.77 -101.31, -4.53 43.9, 75.68 -166.17, 141.69 out-out out 12.6635 Saltbr-out 13.161 HRD-in -67.54, -63.16 83.85, -10.66 out-out-out SNCooo out-out ActLoopNT-out 9.632 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.12, -49.62 APE9-dihe-na -62.67, -34.57 APE8-dihe-out -58.19, -50.78 APE8-rot-in 276.77 APE67-dihe-in -82.12, -28.85 -67.98, -32.83 APE12-dist-out 14.2466 APE11-dist-out 19.2311 APE10-dist-out 20.4004 APE9-dist-out 9.2958 None None None XRAY 2.1 0.225 0.269 A 297.0 279.0 18 33 33 0 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13.0 266.0 254.0 493 494 495 497 499 379 388 392 473 475 474 476.0 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
OTHER BUD32 KAE1B_METJA 2VWBA Q58530 1 530 535.0 ANP:1531 Allosteric Inactive DFGin 6.8437 17.1317 None -120.64, -3.56 -136.03, 137.71 -148.58, 37.82 232.34, 113.93 -66.32, -14.47 in-in in 7.9752 Saltbr-in 2.7284 HRD-out -83.04, 140.14 -107.29, 16.57 in-in-na SNCiia in-na ActLoopNT-in 2.9164 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.96, -33.04 APE9-dihe-na -68.59, -42.86 APE8-dihe-na -73.15, -19.01 APE8-rot-na 294.55 APE67-dihe-na -59.99, -36.61 -63.88, -52.94 APE12-dist-na 17.0179 APE11-dist-na 12.319 APE10-dist-na 14.9692 APE9-dist-na 11.6624 None None None XRAY 3.05 0.224 0.301 A 535.0 519.0 4 23 23 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 2VWBB Q58530 1 532 535.0 ANP:1533 Allosteric Inactive DFGin 6.5797 16.7156 None -128.01, -5.24 -139.71, 160.08 -157.9, 25.33 238.13, 113.59 -41.68, -37.13 in-in in 7.8464 Saltbr-in 3.1753 HRD-out -90.81, 128.03 -91.65, 20.67 in-in-na SNCiia in-na ActLoopNT-in 2.657 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -74.1, -29.36 APE9-dihe-na -76.07, -42.12 APE8-dihe-na -69.9, -15.57 APE8-rot-na 312.74 APE67-dihe-na -42.13, -37.17 -74.66, -63.72 APE12-dist-na 16.6492 APE11-dist-na 12.1119 APE10-dist-na 14.818 APE9-dist-na 11.4755 None None None XRAY 3.05 0.224 0.301 B 535.0 507.0 8 23 23 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 3EN9A Q58530 1 534 535.0 TBR:60601 Allosteric Inactive DFGin 6.6582 16.7462 None -134.44, -0.31 -125.15, 143.48 -154.72, 21.38 233.8, 116.65 -62.18, -16.93 in-in in 7.873 Saltbr-in 2.968 HRD-out -101.58, 104.27 -87.64, 28.76 in-in-na SNCiia in-na ActLoopNT-in 2.6862 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -71.3, -40.31 APE9-dihe-na -58.09, -54.55 APE8-dihe-na -54.72, -36.92 APE8-rot-na 170.93 APE67-dihe-na -64.68, -33.79 -56.83, -50.19 APE12-dist-na 16.5461 APE11-dist-na 11.9879 APE10-dist-na 14.7021 APE9-dist-na 11.8501 None None None XRAY 2.67 0.205 0.264 A 540.0 516.0 9 23 23 0 [[334, 534]] 1.0 3en9 Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.7e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 3EN9B Q58530 1 529 535.0 TBR:60601 Allosteric Inactive DFGin 6.7645 17.0062 None -132.67, 10.26 -148.47, 138.5 -157.5, 29.4 228.09, 116.97 -68.96, -12.89 in-in in 7.9834 Saltbr-in 2.8967 HRD-in -94.77, -42.03 67.36, 13.43 in-in-na SNCiia in-na ActLoopNT-in 2.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.33, -30.37 APE9-dihe-na -63.66, -55.11 APE8-dihe-na -49.33, -47.59 APE8-rot-na 211.79 APE67-dihe-na -76.88, -29.96 -52.7, -40.55 APE12-dist-na 17.2074 APE11-dist-na 12.093 APE10-dist-na 14.5147 APE9-dist-na 11.8468 None None None XRAY 2.67 0.205 0.264 B 540.0 509.0 13 23 23 0 [[334, 534]] 1.0 3en9 Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.7e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 3ENHA Q58530 1 534 535.0 TBR:64769,TBR:65769,TBR:66769 Allosteric,Allosteric,Allosteric Inactive DFGin 6.6093 16.9341 None -95.41, 19.07 -156.54, 140.87 -153.31, 3.02 223.74, 105.19 -20.11, -54.37 in-in in 7.2465 Saltbr-in 2.7218 HRD-out -61.32, 155.11 -124.33, 4.45 in-in-na SNCiia in-na ActLoopNT-in 3.3996 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -51.49, -45.67 APE9-dihe-na -64.17, -38.92 APE8-dihe-na -63.93, -42.61 APE8-rot-na 164.75 APE67-dihe-na -60.92, -57.53 -63.62, -34.7 APE12-dist-na 17.7176 APE11-dist-na 13.0064 APE10-dist-na 15.5998 APE9-dist-na 11.6009 None None None XRAY 3.6 0.274 0.324 A 540.0 495.0 10 23 23 0 [[334, 534]] 1.0 3enh Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.7e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 3ENHB Q58530 1 529 535.0 TBR:62769,TBR:63769,TBR:67769,TBR:68769 Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 6.6197 16.9299 None -94.55, 18.23 -156.56, 140.99 -152.1, 2.98 223.24, 106.74 -21.74, -55.89 in-in in 7.2512 Saltbr-in 2.6963 HRD-out -61.26, 154.71 -123.06, 3.16 in-in-na SNCiia in-na ActLoopNT-in 3.4035 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -51.47, -46.52 APE9-dihe-na -63.92, -38.68 APE8-dihe-na -63.4, -43.04 APE8-rot-na 165.31 APE67-dihe-na -61.32, -57.53 -64.45, -33.8 APE12-dist-na 17.7249 APE11-dist-na 13.0114 APE10-dist-na 15.6248 APE9-dist-na 11.5901 None None None XRAY 3.6 0.274 0.324 B 540.0 485.0 19 23 19 4 [[334, 534]] 1.0 3enh Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.7e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 8UP5B Q58530 345 533 535.0 No_ligand No_ligand Inactive DFGin 7.3138 17.598 None -82.56, 2.91 -148.25, 146.71 -140.26, 27.42 205.97, 89.37 -57.74, -46.99 in-in in 8.4899 Saltbr-in 2.4911 HRD-out -121.34, 101.07 -89.7, 27.11 in-in-na SNCiia in-na ActLoopNT-in 2.8807 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -62.4, -41.79 APE9-dihe-na -62.96, -43.23 APE8-dihe-na -66.74, -35.25 APE8-rot-na 56.7 APE67-dihe-na -60.7, -38.56 -62.84, -43.15 APE12-dist-na 16.8357 APE11-dist-na 11.841 APE10-dist-na 14.1937 APE9-dist-na 11.6432 E478R None None EM 3.56 999.0 999.0 B 203.0 189.0 12 23 23 0 [[334, 534]] 1.0 8up5 Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 9.4e-45 159.6 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
AGC PRKACA KAPCA_MOUSE 4NTTA P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.2546 15.2208 None 58.0, -132.96 -135.23, 163.83 -122.73, 17.77 281.43, 74.72 -41.46, -50.2 in-out in 9.9815 Saltbr-out 4.1938 HRD-in -65.11, -40.77 60.9, 3.38 out-in-in SNCoii in-in ActLoopNT-in 2.8637 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 118.31 APE9-dihe-na 164.12, -173.28 APE8-dihe-in -108.19, 123.7 APE8-rot-in 267.93 APE67-dihe-in -75.4, -22.82 -40.35, -37.34 APE12-dist-in 8.1876 APE11-dist-in 11.1589 APE10-dist-in 5.5421 APE9-dist-in 4.3211 None TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 A 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1SYKA P05132 2 351 351.0 No_ligand No_ligand Inactive DFGin 6.5487 15.2891 None -131.76, 92.58 153.52, 114.28 -135.97, 14.86 305.19, 86.4 -55.43, -35.39 out-out out 10.6501 Saltbr-out 4.6701 HRD-out -89.49, 87.61 -76.68, 28.19 out-in-in SNCoii in-in ActLoopNT-in 2.8271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.89, 158.84 APE9-dihe-na 108.08, 161.46 APE8-dihe-in -68.78, 138.01 APE8-rot-in 292.07 APE67-dihe-in -58.35, -9.3 -44.71, -57.38 APE12-dist-in 8.6724 APE11-dist-in 11.389 APE10-dist-in 5.9774 APE9-dist-in 3.618 E231Q TPO198,SEP339 TPO198,SEP339 XRAY 2.8 0.202 0.249 A 350.0 350.0 0 25 25 0 [[44, 298]] 1.0 1syk Mus musculus AGC_PRKACA_MOUSE AGC 5.7e-94 320.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1SYKB P05132 14 351 351.0 No_ligand No_ligand Inactive DFGin 6.599 15.2944 None -131.1, 91.72 152.06, 111.8 -131.83, 14.93 304.13, 82.92 -52.5, -38.6 out-out out 10.6973 Saltbr-out 4.5374 HRD-out -89.8, 89.72 -78.69, 28.99 out-in-in SNCoii in-in ActLoopNT-in 2.7813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.75, 160.3 APE9-dihe-na 107.8, 162.07 APE8-dihe-in -68.75, 135.04 APE8-rot-in 292.48 APE67-dihe-in -58.91, -9.06 -42.82, -56.64 APE12-dist-in 8.6623 APE11-dist-in 11.3639 APE10-dist-in 5.9602 APE9-dist-in 3.6147 E231Q TPO198,SEP339 TPO198,SEP339 XRAY 2.8 0.202 0.249 B 350.0 325.0 0 25 25 0 [[44, 298]] 1.0 1syk Mus musculus AGC_PRKACA_MOUSE AGC 5.7e-94 320.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A P18654 47 346 740.0 ANP:480 ATPlike Inactive DFGin 5.9199 11.0415 None -85.91, -4.29 -148.29, 179.42 -140.68, 33.76 40.5, 80.74 98.88, 16.23 none-none none 999.0 Saltbr-none 999.0 HRD-in -65.38, -43.56 85.71, -58.97 none-out-none SNCnon out-none ActLoopNT-out 10.0751 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.27 APE8-rot-in 334.43 APE67-dihe-in -57.95, -24.46 -80.48, -16.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.216 0.248 A 325.0 280.0 20 28 17 11 [[68, 327], [422, 679]] 2.0 3g51 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.6e-97 330.9 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
CAMK AURKA AURKA_MOUSE 3DJ5A P97477 119 379 395.0 AK5:60001 Type1.5_Front Inactive DFGin 7.6284 14.0475 None -136.29, 19.35 -86.03, 63.82 -110.83, -25.4 302.03, 108.73 -69.83, 159.06 out-out out 12.978 Saltbr-out 9.961 HRD-out -131.01, 157.62 -122.24, -24.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.12, -1.39 APE9-dihe-na 118.23, -161.25 APE8-dihe-in -83.03, 126.77 APE8-rot-in 300.87 APE67-dihe-in -53.36, -22.0 -45.96, -54.49 APE12-dist-out 14.9045 APE11-dist-out 15.549 APE10-dist-out 15.4089 APE9-dist-out 17.2512 N164G,K218R,M280L None None XRAY 1.8 0.21 0.243 A 272.0 252.0 9 26 17 9 [[124, 374]] 1.0 3dj5 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3DJ6A P97477 119 379 395.0 AK6:60001 Type1.5_Front Inactive DFGin 7.5112 14.321 None -137.4, 19.75 -87.35, 63.1 -109.74, -19.59 301.75, 109.1 -74.07, 159.87 out-out out 12.9421 Saltbr-out 9.941 HRD-out -131.2, 158.79 -119.8, -29.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -104.43, 1.85 APE9-dihe-na 118.27, -159.99 APE8-dihe-in -81.23, 128.14 APE8-rot-in 303.03 APE67-dihe-in -53.67, -23.26 -47.45, -53.56 APE12-dist-out 15.1307 APE11-dist-out 15.7144 APE10-dist-out 15.886 APE9-dist-out 17.3598 N164G,K218R,M280L None None XRAY 1.7 0.217 0.261 A 272.0 252.0 9 26 17 9 [[124, 374]] 1.0 3dj6 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK RPS6KA3-2 KS6A3_MOUSE 4MAOA P18654 415 712 740.0 28D:801 Type1 Inactive DFGin 6.9498 13.9692 None -122.16, -3.09 -110.62, -87.21 89.06, 8.42 296.98, 89.53 -66.42, 0.71 in-in in 8.7172 Saltbr-in 3.0464 HRD-in -80.58, -55.21 74.16, -0.39 in-in-out SNCiio in-out ActLoopNT-in 2.9492 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -78.96, -40.3 APE9-dihe-na -99.2, 112.48 APE8-dihe-out -111.75, -5.25 APE8-rot-out 40.44 APE67-dihe-out -98.05, 166.61 -67.15, -3.4 APE12-dist-out 18.9517 APE11-dist-out 18.4684 APE10-dist-out 22.8607 APE9-dist-out 24.2627 T493M,K591E None None XRAY 2.6 0.238 0.292 A 355.0 298.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4mao Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 1.1e-87 299.7 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
CMGC MAPK14 MK14_MOUSE 6SOUA P47811 5 352 360.0 LPZ:406,LPZ:407 Allosteric,Type1 Inactive DFGin 7.3625 16.8084 None -133.04, -176.46 59.36, 52.66 -52.08, 999.0 288.27, 77.53 999.0, 999.0 in-in in 9.7302 Saltbr-in 2.8273 HRD-in -72.19, -51.58 83.69, -12.25 in-out-out SNCioo out-out ActLoopNT-out 12.0028 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.59, 133.82 APE9-dihe-na -63.41, -18.88 APE8-dihe-out -63.42, -15.13 APE8-rot-out 53.27 APE67-dihe-in -66.48, -19.16 -115.28, -17.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8872 None None None XRAY 1.5 0.216 0.233 A 381.0 342.0 6 25 22 3 [[24, 308]] 1.0 6sou Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3TG1A P47811 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.8247 16.0345 None -116.32, 155.59 -1.61, 110.61 -70.76, 999.0 331.08, 173.37 999.0, 999.0 in-in in 9.7774 Saltbr-in 3.192 HRD-in -71.22, -51.39 75.49, -16.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.05 APE8-dihe-out -54.64, -33.8 APE8-rot-out 159.97 APE67-dihe-in -72.3, -17.1 -60.98, -22.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2156 None None None XRAY 2.71 0.311 0.26 A 380.0 334.0 14 25 11 14 [[24, 308]] 1.0 3tg1 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 2GHMA P47811 5 352 360.0 LIC:353 Type1 Inactive DFGin 5.7845 13.7767 None -78.81, 171.19 -55.87, 93.41 -25.52, 88.72 34.83, 93.47 -170.14, 167.5 in-in in 9.288 Saltbr-in 3.2035 HRD-in -62.78, -61.35 90.75, -25.48 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -53.87 APE9-dihe-na -71.96, -67.71 APE8-dihe-out -49.26, -48.1 APE8-rot-in 270.21 APE67-dihe-in -62.91, -14.17 -44.49, -46.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.3212 APE9-dist-out 11.3867 T180A,Y182F None None XRAY 2.35 0.232 0.323 A 348.0 336.0 12 25 14 11 [[24, 308]] 1.0 2ghm Mus musculus CMGC_MAPK14_MOUSE CMGC 6.3e-84 287.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 1YW2A P47811 4 353 360.0 PGJ:62001 Type1 Inactive DFGin 7.4408 13.8889 None -108.87, 130.98 -78.03, -31.11 -137.46, 121.59 317.27, 85.69 -153.54, 999.0 in-in in 9.1653 Saltbr-in 2.8889 HRD-in -65.03, -58.53 71.57, -11.34 in-out-out SNCioo out-out ActLoopNT-out 19.2412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 140.08 APE9-dihe-na -171.64, 79.36 APE8-dihe-out -4.97, -52.19 APE8-rot-out 22.63 APE67-dihe-in -78.16, -22.44 -73.05, -7.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3444 T180A,Y182F None None XRAY 2.01 0.207 0.29 A 360.0 341.0 9 25 16 9 [[24, 308]] 1.0 1yw2 Mus musculus CMGC_MAPK14_MOUSE CMGC 7.1e-84 287.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 2GTMA P47811 5 352 360.0 LID:353 Type1 Inactive DFGin 10.5798 12.2976 None -99.42, 151.2 -66.85, -46.24 -140.98, 139.16 303.6, 104.59 -99.33, -162.53 in-in in 9.0195 Saltbr-in 2.6326 HRD-in -70.94, -57.65 84.88, -6.9 in-out-out SNCioo out-out ActLoopNT-out 21.3254 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -146.35, 106.63 APE9-dihe-na -84.71, 129.28 APE8-dihe-out -45.44, -51.38 APE8-rot-in 285.81 APE67-dihe-in -54.42, -30.85 -58.09, -32.0 APE12-dist-none 999.0 APE11-dist-in 10.9379 APE10-dist-out 9.1615 APE9-dist-out 10.8018 None None None XRAY 1.9 0.231 0.261 A 348.0 341.0 7 25 21 4 [[24, 308]] 1.0 2gtm Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 2GTNA P47811 5 352 360.0 LIE:354 Type1 Inactive DFGin 10.5589 12.1049 None -97.49, 148.4 -66.36, -50.18 -132.83, 140.82 310.6, 94.93 -102.32, -165.42 in-in in 8.8869 Saltbr-in 2.5937 HRD-in -68.82, -53.97 78.95, -12.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.88 APE8-dihe-out -46.6, -50.56 APE8-rot-in 275.26 APE67-dihe-in -60.86, -30.99 -59.17, -25.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8082 None None None XRAY 1.8 0.203 0.248 A 348.0 337.0 11 25 14 11 [[24, 308]] 1.0 2gtn Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8ACOAAA P47811 4 352 360.0 SB2:401 Type1 Inactive DFGin 5.7374 14.0092 None -148.97, 178.49 24.89, 96.95 -83.03, 999.0 316.51, 111.13 999.0, 999.0 in-in in 9.3324 Saltbr-in 2.582 HRD-in -68.93, -56.93 87.8, -49.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -122.76 APE8-rot-in 323.22 APE67-dihe-in -64.13, -36.89 -112.86, 8.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.212 0.278 AAA 359.0 334.0 15 25 10 15 [[24, 308]] 1.0 8aco Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9UA P47811 5 352 360.0 JMM:401 Type1 Inactive DFGin 7.8704 16.4146 None -105.42, 167.68 86.02, 81.87 -120.77, 999.0 293.85, 91.32 999.0, 999.0 in-in in 9.5521 Saltbr-in 2.9149 HRD-in -68.92, -55.3 81.59, -7.51 in-out-out SNCioo out-out ActLoopNT-out 10.0022 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -133.83, 134.83 APE9-dihe-na -63.75, -21.85 APE8-dihe-out -58.31, -17.35 APE8-rot-out 54.12 APE67-dihe-in -65.05, -20.74 -118.93, -19.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6787 None None None XRAY 1.67 0.187 0.213 A 360.0 345.0 3 25 22 3 [[24, 308]] 1.0 5r9u Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8EFJA P47811 5 360 360.0 WHQ:503 Type1 Inactive DFGin 6.6842 15.1508 None -107.83, -138.53 -47.2, 131.52 -82.89, 153.62 283.8, 59.38 -72.43, 123.55 in-in in 9.147 Saltbr-in 2.8713 HRD-in -63.56, -52.6 86.58, -8.43 in-out-out SNCioo out-out ActLoopNT-out 9.1047 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -48.45 APE9-dihe-na -142.16, 106.07 APE8-dihe-in -57.79, 138.19 APE8-rot-out 182.41 APE67-dihe-in -58.85, -41.56 -95.36, -2.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.8627 APE9-dist-out 9.537 None None None XRAY 2.31 0.193 0.223 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8efj Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8VMHA P47811 5 354 360.0 A1ACT:603 Type1 Inactive DFGin 10.8876 12.6554 None -91.57, 155.22 -78.87, -42.97 -134.13, 132.21 306.13, 106.97 -93.28, -173.32 in-in in 9.1199 Saltbr-in 2.4999 HRD-in -70.23, -50.72 73.72, -8.99 in-out-out SNCioo out-out ActLoopNT-out 21.4911 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 65.99 APE9-dihe-na -65.29, 141.53 APE8-dihe-out -65.65, -35.56 APE8-rot-in 296.74 APE67-dihe-in -54.93, -23.21 -63.02, -29.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.7755 APE9-dist-out 11.8061 None None None XRAY 2.46 0.21 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmh Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8VMMA P47811 5 354 360.0 A1ACP:602 Type1 Inactive DFGin 10.9836 13.1585 None -98.06, 143.62 -67.61, -42.07 -138.88, 122.62 295.3, 103.53 -85.47, 178.15 in-in in 9.4266 Saltbr-in 2.5383 HRD-in -74.94, -56.81 76.36, -7.57 in-out-out SNCioo out-out ActLoopNT-out 21.1108 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.41 APE9-dihe-na -75.99, -11.35 APE8-dihe-out 77.98, -40.95 APE8-rot-in 311.13 APE67-dihe-in -68.54, -15.53 -53.31, -26.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5031 APE9-dist-out 11.8253 None None None XRAY 2.4 0.207 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8VT6A P47811 5 360 360.0 WHQ:503 Type1 Inactive DFGin 6.7293 15.1507 None -106.7, -137.28 -49.07, 131.85 -82.77, 153.72 284.07, 57.8 -72.41, 123.53 in-in in 9.1741 Saltbr-in 2.5587 HRD-in -64.24, -49.87 82.02, -7.33 in-out-out SNCioo out-out ActLoopNT-out 9.1157 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -58.08 APE9-dihe-na -131.51, 108.06 APE8-dihe-in -61.02, 149.49 APE8-rot-out 183.06 APE67-dihe-in -60.32, -29.4 -95.05, -11.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.7558 APE9-dist-out 9.4982 None None None XRAY 2.31 0.166 0.216 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8vt6 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8VWMA P47811 5 360 360.0 WHE:401 Type1 Inactive DFGin 6.7659 15.2325 None -105.37, -136.33 -48.31, 132.67 -83.1, 152.37 281.96, 61.27 -72.7, 123.36 in-in in 9.177 Saltbr-in 2.8721 HRD-in -65.49, -53.48 85.5, -8.91 in-out-out SNCioo out-out ActLoopNT-out 9.1811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -44.6 APE9-dihe-na -141.61, 100.51 APE8-dihe-in -61.36, 142.62 APE8-rot-out 185.47 APE67-dihe-in -63.84, -26.29 -92.21, -4.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.0139 APE9-dist-out 9.637 None None None XRAY 1.94 0.177 0.222 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8vwm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 2EWAA P47811 5 354 360.0 SB2:361 Type1 Inactive DFGin 6.575 15.1465 None -155.19, 179.59 -144.72, 110.73 -99.77, 145.73 66.01, 43.3 59.16, 999.0 in-in in 9.4738 Saltbr-in 2.6977 HRD-in -67.14, -51.92 76.56, -18.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -36.62 APE8-rot-in 319.01 APE67-dihe-in -54.41, -29.01 -77.11, -17.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.241 0.279 A 379.0 330.0 20 25 11 14 [[24, 308]] 1.0 2ewa Mus musculus CMGC_MAPK14_MOUSE CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 6YCUA P47811 6 359 360.0 SB4:401,OKZ:405 Type1,Allosteric Inactive DFGin 6.0979 14.3679 None -143.57, 175.48 60.18, 42.46 -110.51, 999.0 50.6, 83.02 999.0, 999.0 in-in in 9.1165 Saltbr-in 2.6532 HRD-in -71.9, -56.23 80.62, -14.35 in-out-out SNCioo out-out ActLoopNT-out 10.3489 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -118.54, 114.44 APE9-dihe-na -89.96, 150.08 APE8-dihe-in -65.08, 137.29 APE8-rot-in 294.76 APE67-dihe-in -63.71, -21.71 -110.97, 4.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7014 C162S None None XRAY 1.35 0.232 0.253 A 360.0 347.0 7 25 18 7 [[24, 308]] 1.0 6ycu Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
OTHER EIF2AK3 E2AK3_MOUSE 3QD2B Q9Z2B5 582 1078 1114.0 No_ligand No_ligand Inactive DFGin 6.7724 14.1264 None -150.06, 46.53 -144.12, 85.35 -92.69, 31.02 296.57, 72.54 -64.49, -13.2 in-in in 8.8002 Saltbr-in 3.0494 HRD-in -78.7, -42.73 44.71, 30.97 in-in-out SNCiio in-out ActLoopNT-in 2.6916 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_iiin APE10-dihe-na -139.11, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 13.91 APE8-rot-out 183.4 APE67-dihe-out -53.62, -40.83 54.78, -116.69 APE12-dist-in 11.9859 APE11-dist-in 12.2601 APE10-dist-in 7.0504 APE9-dist-none 999.0 None TPO980 TPO980 XRAY 2.81 0.273 0.332 B 332.0 272.0 60 40 25 15 [[382, 1075]] 1.0 3qd2 Mus musculus OTHER_EIF2AK3_MOUSE OTHER 5e-49 173.1 2.0 254.0 253.0 952 953 954 956 958 618 635 639 932 934 933 935.0 1004 992 987 986 985 984 983 982 981 887 Eukaryotic translation initiation factor 2-alpha kinase 3
STE STK39 STK39_MOUSE 5DBXA Q9Z1W9 65 365 556.0 ANP:401 ATPlike Inactive DFGin 6.8713 15.5873 None -61.74, 151.25 -53.68, 129.38 -99.47, -2.77 72.69, 109.41 -58.5, -56.73 out-out out 16.0249 Saltbr-out 17.4351 HRD-in -69.21, -49.56 75.54, -19.7 out-out-out SNCooo out-out ActLoopNT-out 5.6736 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -90.7, -9.1 APE9-dihe-na -96.35, 164.45 APE8-dihe-in -91.01, 125.18 APE8-rot-in 324.0 APE67-dihe-in -65.76, -19.67 -49.27, -43.15 APE12-dist-none 999.0 APE11-dist-out 25.0408 APE10-dist-out 28.2167 APE9-dist-out 27.3477 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 A 328.0 288.0 13 33 20 13 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5DBXB Q9Z1W9 65 364 556.0 ANP:401 ATPlike Inactive DFGin 6.3307 15.0679 None -67.52, 160.16 -60.64, 125.44 -102.44, -1.98 62.33, 96.08 -52.97, -52.55 out-out out 14.0364 Saltbr-out 13.266 HRD-in -73.49, -48.67 74.98, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.6752 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -104.19, 109.41 APE9-dihe-na 87.86, -153.92 APE8-dihe-in -128.52, 139.93 APE8-rot-in 317.58 APE67-dihe-in -74.81, -17.12 -52.01, -48.65 APE12-dist-none 999.0 APE11-dist-out 25.567 APE10-dist-out 25.1599 APE9-dist-out 27.7398 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 B 328.0 286.0 14 33 23 10 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK3 RIPK3_MOUSE 9IWYB Q9QZL0 15 311 486.0 A1D97:60401 Type1 Inactive DFGin 6.9678 14.0618 None -141.15, 157.34 72.96, -21.93 37.23, 42.97 300.12, 81.7 83.46, 13.22 in-none in 9.1083 Saltbr-none 999.0 HRD-in -65.47, -42.38 68.5, -9.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -44.45 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.27 0.299 B 325.0 249.0 48 34 11 23 [[20, 290]] 1.0 9iwy Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LFVB Q9QZL0 14 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.0186 14.0765 None -145.36, 167.9 72.34, -50.6 63.07, 38.87 298.34, 85.19 73.03, 11.82 out-out out 13.2292 Saltbr-out 11.3207 HRD-in -75.72, -32.7 64.15, -13.21 out-out-none SNCoon out-none ActLoopNT-out 11.1831 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -75.83, -8.32 999.0, 22.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 B 325.0 256.0 42 34 14 20 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LFVC Q9QZL0 14 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.0132 13.8713 None -142.11, 177.11 62.46, -56.12 66.46, 24.11 299.69, 104.14 92.05, 19.19 out-none out 13.5118 Saltbr-none 999.0 HRD-in -83.63, -35.26 71.15, -28.83 none-out-none SNCnon out-none ActLoopNT-out 11.3085 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.07, -0.33 999.0, 20.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 C 325.0 250.0 48 34 13 21 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LFVD Q9QZL0 13 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.0646 13.893 None -144.3, 176.32 70.73, -56.46 59.33, 41.69 299.17, 86.38 64.18, 23.93 out-none out 14.4012 Saltbr-none 999.0 HRD-in -78.46, -41.38 66.14, 7.65 none-out-none SNCnon out-none ActLoopNT-out 11.2611 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.45 APE8-rot-none 999.0 APE67-dihe-in -71.04, -19.34 -115.22, 23.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 D 325.0 255.0 44 34 14 20 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LFVA Q9QZL0 13 311 486.0 A1EJO:60401,A1EJP:60402 Type1,Type1 Inactive DFGin 7.3303 14.1402 None -146.0, 165.54 71.61, -51.04 65.28, 34.98 298.07, 86.12 73.14, 14.66 out-none out 13.2609 Saltbr-none 999.0 HRD-in -73.78, -36.28 68.29, -16.9 none-out-out SNCnoo out-out ActLoopNT-out 11.3875 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 42.16 APE8-dihe-in -76.77, 175.03 APE8-rot-none 999.0 APE67-dihe-in -74.57, -14.2 -136.84, 23.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0663 None None None XRAY 2.78 0.249 0.28 A 325.0 259.0 40 34 16 18 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR EPHA4 EPHA4_MOUSE 2Y6MA Q03137 609 891 986.0 No_ligand No_ligand Inactive DFGin 6.0821 15.1035 None -124.48, -160.87 67.79, 62.91 -108.47, 999.0 294.78, 105.52 999.0, 999.0 in-in in 8.2842 Saltbr-in 3.23 HRD-in -72.28, -48.83 78.34, -12.81 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.74 APE8-rot-na 31.74 APE67-dihe-in -75.57, -4.4 -48.65, -50.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.176 0.203 A 291.0 262.0 21 31 10 21 [[621, 880]] 1.0 2y6m Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
TYR EPHA4 EPHA4_MOUSE 2Y6OA Q03137 609 891 986.0 1N1:1892 Type1 Inactive DFGin 6.5237 15.3156 None -125.69, -163.2 68.45, 65.65 -111.22, 999.0 295.37, 106.51 999.0, 999.0 in-in in 8.2042 Saltbr-in 2.6896 HRD-in -74.99, -48.94 76.82, -16.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.47 APE8-dihe-in -69.65, 86.1 APE8-rot-na 27.26 APE67-dihe-in -78.79, 0.73 -48.0, -50.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6377 None None None XRAY 1.543 0.181 0.201 A 291.0 263.0 20 31 11 20 [[621, 880]] 1.0 2y6o Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
TYR EPHA4 EPHA4_MOUSE 2XYUA Q03137 612 891 986.0 Q9G:1898 Type1.5_Back Inactive DFGin 6.3198 15.1855 None -125.63, -157.19 61.91, 64.04 -108.95, 999.0 298.3, 101.76 999.0, 999.0 in-out in 8.6238 Saltbr-out 3.6792 HRD-in -75.11, -49.97 80.15, -19.41 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -122.04 APE8-dihe-in -73.35, 87.97 APE8-rot-na 33.09 APE67-dihe-in -58.55, -20.01 -45.52, -53.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.5889 None None None XRAY 2.117 0.192 0.23 A 285.0 260.0 20 31 11 20 [[621, 880]] 1.0 2xyu Mus musculus TYR_EPHA4_MOUSE TYR 1.5e-109 371.3 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
TYR EPHB2 EPHB2_MOUSE 1JPAA P54763 594 892 986.0 ANP:60400 ATPlike Inactive DFGin 5.7088 15.4887 None -134.81, -163.21 68.34, 57.99 -95.68, 999.0 294.45, 106.32 999.0, 999.0 in-in in 7.779 Saltbr-in 3.0192 HRD-in -67.2, -47.6 76.65, -18.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.15 APE8-rot-na 35.93 APE67-dihe-in -72.25, 3.83 -49.21, -49.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 A 312.0 273.0 26 33 10 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 1JPAB P54763 594 891 986.0 ANP:60401 ATPlike Inactive DFGin 5.7317 15.6268 None -133.42, -158.93 64.89, 61.18 -100.9, 999.0 292.25, 96.96 999.0, 999.0 in-in in 7.8146 Saltbr-in 2.6861 HRD-in -67.92, -50.57 78.02, -16.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.77 APE8-rot-na 326.13 APE67-dihe-in -71.91, 4.89 -51.95, -48.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 B 312.0 269.0 29 33 10 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR JAK1-12 JAK1_MOUSE 7T6FA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.8989 13.8131 None -86.13, -125.98 -78.37, 170.67 -132.74, 42.36 300.4, 95.7 -63.52, -44.16 in-out in 8.2656 Saltbr-out 5.3454 HRD-in -74.55, -24.53 68.9, -7.15 out-in-out SNCoio in-out ActLoopNT-in 3.3664 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.97, -30.61 APE9-dihe-in -69.86, 145.09 APE8-dihe-in -65.5, 154.45 APE8-rot-na 337.81 APE67-dihe-in -111.81, 34.03 -69.03, -47.03 APE12-dist-na 13.0701 APE11-dist-na 13.989 APE10-dist-na 8.6737 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 A 1173.0 1043.0 23 31 31 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 7T6FB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.8984 13.8132 None -86.09, -125.95 -78.45, 170.72 -132.73, 42.29 300.45, 95.61 -63.42, -44.2 in-out in 8.2667 Saltbr-out 5.3471 HRD-in -74.65, -24.42 68.9, -7.11 out-in-out SNCoio in-out ActLoopNT-in 3.3661 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.91, -30.65 APE9-dihe-in -69.79, 145.09 APE8-dihe-in -65.5, 154.47 APE8-rot-na 337.81 APE67-dihe-in -111.9, 34.05 -69.03, -46.98 APE12-dist-na 13.0694 APE11-dist-na 13.9887 APE10-dist-na 8.6729 APE9-dist-in 6.3604 None None None EM 3.6 999.0 999.0 B 1173.0 1043.0 23 31 31 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
OTHER PKNB PKNB_MYCTU 2FUMC P9WI81 3 278 626.0 MIX:2539 Type1 Inactive DFGin 6.7878 14.8635 None -107.89, 177.03 62.6, 100.21 -107.18, 999.0 281.46, 57.46 999.0, 999.0 in-out in 8.6071 Saltbr-out 3.6832 HRD-in -81.39, -39.9 72.99, -11.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -167.24, 35.45 999.0, 145.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.89 0.221 0.278 C 299.0 254.0 22 31 9 22 [[11, 273]] 1.0 2fum Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 6.4e-46 162.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNF PKNF_MYCTU 7NAAA P9WI75 3 278 476.0 V17:600 Type1 Inactive DFGin 7.7664 16.4453 None -112.2, 163.88 72.45, 37.21 -60.92, 999.0 258.19, 101.89 999.0, 999.0 out-none out 12.9162 Saltbr-none 999.0 HRD-in -69.89, -56.45 85.3, -7.85 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.62 APE8-rot-out 181.35 APE67-dihe-in -63.12, -31.84 -114.62, 2.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.239 0.279 A 278.0 244.0 32 30 10 20 [[12, 267]] 1.0 7naa Mycobacterium tuberculosis OTHER_PKNF_MYCTU STE 1.2e-34 125.8 2.0 246.0 245.0 158 159 160 162 164 41 60 64 134 136 135 137.0 200 188 183 182 181 180 179 178 177 90 Serine/threonine-protein kinase PknF
OTHER PKNF PKNF_MYCTU 7NAAB P9WI75 3 278 476.0 V17:600 Type1 Inactive DFGin 7.4177 16.5949 None -114.27, 168.92 71.71, 39.27 -62.75, 999.0 268.87, 95.33 999.0, 999.0 out-none out 12.8665 Saltbr-none 999.0 HRD-in -67.45, -56.53 84.54, -6.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na -78.82, 72.55 APE9-dihe-na -80.85, -149.02 APE8-dihe-in -78.11, 81.4 APE8-rot-none 999.0 APE67-dihe-in -60.78, -32.32 -74.67, -0.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7484 None None None XRAY 2.75 0.239 0.279 B 278.0 242.0 34 30 13 17 [[12, 267]] 1.0 7naa Mycobacterium tuberculosis OTHER_PKNF_MYCTU STE 1.2e-34 125.8 2.0 246.0 245.0 158 159 160 162 164 41 60 64 134 136 135 137.0 200 188 183 182 181 180 179 178 177 90 Serine/threonine-protein kinase PknF
OTHER PKNF PKNF_MYCTU 7NAAC P9WI75 24 278 476.0 V17:600 Type1 Inactive DFGin 7.0903 17.2267 None -115.54, 167.53 69.83, 39.44 -59.86, 999.0 246.36, 96.78 999.0, 999.0 out-none out 11.1454 Saltbr-none 999.0 HRD-in -68.86, -54.99 86.29, -8.12 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.94 APE8-rot-out 180.81 APE67-dihe-in -58.59, -31.71 -117.18, 5.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.239 0.279 C 278.0 217.0 50 30 10 20 [[12, 267]] 1.0 7naa Mycobacterium tuberculosis OTHER_PKNF_MYCTU STE 1.2e-34 125.8 2.0 246.0 245.0 158 159 160 162 164 41 60 64 134 136 135 137.0 200 188 183 182 181 180 179 178 177 90 Serine/threonine-protein kinase PknF
OTHER PKNF PKNF_MYCTU 7NAAD P9WI75 4 277 476.0 V17:600 Type1 Inactive DFGin 7.6663 17.2179 None -113.76, 166.59 72.03, 37.97 -62.58, 999.0 259.82, 100.49 999.0, 999.0 out-none out 10.5853 Saltbr-none 999.0 HRD-in -71.7, -42.16 79.2, -20.03 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.09 APE8-rot-out 183.09 APE67-dihe-in -61.16, -30.28 -118.68, 8.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.239 0.279 D 278.0 234.0 40 30 10 20 [[12, 267]] 1.0 7naa Mycobacterium tuberculosis OTHER_PKNF_MYCTU STE 1.2e-34 125.8 2.0 246.0 245.0 158 159 160 162 164 41 60 64 134 136 135 137.0 200 188 183 182 181 180 179 178 177 90 Serine/threonine-protein kinase PknF
OTHER PAN3 PAN3_NEUCR 4BWKA Q7SDP4 235 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.4954 13.0897 None -115.86, 18.21 -139.38, 20.36 -67.09, 152.08 286.46, 999.0 74.54, -4.0 out-na out 14.2196 Saltbr-na 999.0 HRD-in -64.9, -42.26 69.75, -63.5 na-out-na SNCaoa out-na ActLoopNT-out 6.8983 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -56.05, -33.42 APE9-dihe-na -88.79, -48.0 APE8-dihe-na -71.22, -9.91 APE8-rot-na 304.05 APE67-dihe-na -61.19, -29.14 -123.36, 9.46 APE12-dist-na 1.5354 APE11-dist-na 4.8946 APE10-dist-na 5.2051 APE9-dist-na 11.4637 None None None XRAY 3.3 0.254 0.294 A 429.0 392.0 10 15 15 0 [[258, 516]] 1.0 4bwk Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWKB Q7SDP4 235 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.0984 12.8973 None -116.7, 18.5 -139.0, 22.15 -67.02, 151.82 287.13, 999.0 73.49, -6.49 out-na out 13.8627 Saltbr-na 999.0 HRD-in -66.71, -43.56 68.66, -62.54 na-out-na SNCaoa out-na ActLoopNT-out 6.9009 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -57.01, -33.89 APE9-dihe-na -87.36, -45.86 APE8-dihe-na -67.7, -8.98 APE8-rot-na 303.47 APE67-dihe-na -166.92, 999.0 -122.6, 109.05 APE12-dist-na 1.57 APE11-dist-na 4.9263 APE10-dist-na 5.3667 APE9-dist-na 12.4323 None None None XRAY 3.3 0.254 0.294 B 429.0 387.0 14 15 10 5 [[258, 516]] 1.0 4bwk Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYB Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.6364 12.9995 None -108.01, 7.82 -124.9, 18.28 -71.16, 143.54 291.41, 999.0 81.95, -4.35 out-na out 13.9696 Saltbr-na 999.0 HRD-in -64.78, -43.28 69.3, -58.59 na-out-na SNCaoa out-na ActLoopNT-out 7.0417 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -68.73, -37.24 APE9-dihe-na -75.95, -42.57 APE8-dihe-na -71.33, -35.43 APE8-rot-na 302.88 APE67-dihe-na -61.0, -48.02 -101.37, 21.03 APE12-dist-na 1.5444 APE11-dist-na 4.8399 APE10-dist-na 5.8244 APE9-dist-na 11.7693 None None None XRAY 3.4 0.223 0.263 B 429.0 403.0 6 15 15 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYD Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.3891 12.6265 None -108.63, 8.9 -122.37, 20.29 -71.82, 141.42 292.67, 999.0 81.18, -5.38 out-na out 13.9082 Saltbr-na 999.0 HRD-in -65.6, -43.11 68.0, -59.39 na-out-na SNCaoa out-na ActLoopNT-out 6.9602 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.97, -39.27 APE9-dihe-na -74.97, -41.75 APE8-dihe-na -69.88, -35.71 APE8-rot-na 304.18 APE67-dihe-na -59.83, -48.03 -102.6, 21.19 APE12-dist-na 1.5346 APE11-dist-na 4.8332 APE10-dist-na 5.6883 APE9-dist-na 12.0116 None None None XRAY 3.4 0.223 0.263 D 429.0 403.0 6 15 15 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWXA Q7SDP4 234 646 656.0 AGS:1647 ATPlike Pseudo DFGin 7.9417 12.8154 None -114.92, 18.69 -139.36, 20.25 -66.2, 154.39 287.13, 999.0 71.2, -3.87 out-na out 14.696 Saltbr-na 999.0 HRD-in -65.26, -41.46 68.71, -60.85 na-out-na SNCaoa out-na ActLoopNT-out 6.8523 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -57.52, -32.86 APE9-dihe-na -89.29, -47.03 APE8-dihe-na -70.13, -10.67 APE8-rot-na 304.73 APE67-dihe-na -61.75, -33.62 -123.15, 12.73 APE12-dist-na 1.5381 APE11-dist-na 4.8657 APE10-dist-na 5.325 APE9-dist-na 11.9168 L510M,G511P,G512M,T514G,T515A,H516R,L517F None None XRAY 2.85 0.213 0.242 A 429.0 395.0 10 15 15 0 [[258, 516]] 1.0 4bwx Neurospora crassa OTHER_PAN3_NEUCR PAN3 1.1e-59 210.5 4.0 282.0 279.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWXB Q7SDP4 234 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.0622 12.9423 None -115.89, 18.73 -138.78, 21.11 -66.02, 153.84 287.45, 999.0 70.44, -4.24 out-na out 13.5168 Saltbr-na 999.0 HRD-in -64.84, -41.41 68.02, -61.18 na-out-na SNCaoa out-na ActLoopNT-out 6.8899 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -59.2, -32.89 APE9-dihe-na -88.22, -46.65 APE8-dihe-na -69.2, -11.95 APE8-rot-na 305.01 APE67-dihe-na -59.96, -34.44 -124.18, 13.25 APE12-dist-na 1.54 APE11-dist-na 4.8646 APE10-dist-na 5.3607 APE9-dist-na 12.0065 L510M,G511P,G512M,T514G,T515A,H516R,L517F None None XRAY 2.85 0.213 0.242 B 429.0 397.0 6 15 15 0 [[258, 516]] 1.0 4bwx Neurospora crassa OTHER_PAN3_NEUCR PAN3 1.1e-59 210.5 4.0 282.0 279.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PINK1 PINK1_PEDHC 7T3XA E0W1I1 119 573 575.0 No_ligand No_ligand Inactive DFGin 9.0832 15.3275 None -120.36, -70.42 -69.88, 89.38 -85.01, 15.83 278.07, 80.04 -61.99, -24.85 in-in in 8.0329 Saltbr-in 3.2399 HRD-in -65.16, -48.73 62.37, 8.53 in-in-in SNCiii in-in ActLoopNT-in 2.8506 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -173.08, -178.78 APE9-dihe-na -86.9, -67.98 APE8-dihe-in -69.61, 90.7 APE8-rot-na 192.26 APE67-dihe-in -65.06, -61.21 -69.1, -21.75 APE12-dist-in 9.2026 APE11-dist-in 11.0695 APE10-dist-in 6.8401 APE9-dist-in 4.3333 D334A None None XRAY 3.53 0.218 0.249 A 463.0 399.0 31 34 34 0 [[64, 514]] 1.0 7t3x Pediculus humanus OTHER_PINK1_PEDHC PINK1 1.6e-85 293.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
CMGC PK6 Q8IDW1_PLAF7 9CMZA Q8IDW1 4 294 305.0 A1AZE:405 Type1 Inactive DFGin 5.9578 12.5997 None -94.14, -157.81 -38.02, 124.16 -88.24, 13.86 299.83, 1.24 -70.53, -12.65 in-in in 9.1302 Saltbr-in 2.8519 HRD-in -80.4, -44.87 68.81, 6.06 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -67.42, -47.85 APE9-dihe-na -56.07, 137.1 APE8-dihe-in -48.14, 142.29 APE8-rot-in 301.26 APE67-dihe-in -63.45, -19.54 -54.62, -52.55 APE12-dist-in 13.528 APE11-dist-in 11.9916 APE10-dist-in 6.3177 APE9-dist-in 3.5559 C44N,C53R,K86A,C222N,K237A None None XRAY 2.45 0.221 0.255 A 306.0 278.0 13 25 25 0 [[9, 293]] 1.0 9cmz Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.2e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CMGC PK6 Q8IDW1_PLAF7 9CMZB Q8IDW1 4 296 305.0 A1AZE:403 Type1 Inactive DFGin 5.9492 12.3581 None -87.61, -154.47 -39.14, 133.87 -103.66, 12.02 299.03, 6.05 -77.37, -6.63 in-in in 9.3411 Saltbr-in 2.7516 HRD-in -77.49, -49.61 70.86, 8.17 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -64.12, -41.81 APE9-dihe-na -63.53, 145.63 APE8-dihe-in -55.7, 134.62 APE8-rot-in 319.67 APE67-dihe-in -64.53, -20.52 -45.12, -48.09 APE12-dist-in 13.2082 APE11-dist-in 11.7673 APE10-dist-in 6.036 APE9-dist-in 3.6503 C44N,C53R,K86A,C222N,K237A None None XRAY 2.45 0.221 0.255 B 306.0 284.0 9 25 25 0 [[9, 293]] 1.0 9cmz Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.2e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CMGC PK6 Q8IDW1_PLAF7 9CMZC Q8IDW1 4 295 305.0 A1AZE:402 Type1 Inactive DFGin 6.0911 13.2991 None -103.9, -129.12 -42.46, 117.59 -94.29, 9.37 297.87, 3.31 -71.04, -2.09 in-none in 9.7093 Saltbr-none 999.0 HRD-in -71.55, -46.08 68.76, 6.39 none-in-in SNCnii in-in ActLoopNT-in 2.8638 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.14, -45.59 APE9-dihe-na -71.51, 142.15 APE8-dihe-in -54.87, 141.86 APE8-rot-in 290.82 APE67-dihe-in -54.29, -32.67 -58.55, -41.7 APE12-dist-in 13.1707 APE11-dist-in 11.8463 APE10-dist-in 6.3518 APE9-dist-in 3.1273 C44N,C53R,K86A,C222N,K237A None None XRAY 2.45 0.221 0.255 C 306.0 271.0 21 25 25 0 [[9, 293]] 1.0 9cmz Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.2e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CMGC PK6 Q8IDW1_PLAF7 8U2OA Q8IDW1 1 298 305.0 V3O:60405 Type1 Inactive DFGin 5.8965 12.5105 None -94.96, -148.98 -42.04, 131.33 -95.74, 12.17 304.54, 179.87 -67.72, -14.66 in-in in 9.5513 Saltbr-in 2.5363 HRD-in -78.09, -50.71 66.76, 14.89 in-in-in SNCiii in-in ActLoopNT-in 2.8753 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -72.6, -44.34 APE9-dihe-na -64.9, 136.38 APE8-dihe-in -57.5, 138.34 APE8-rot-in 311.13 APE67-dihe-in -57.61, -26.63 -51.17, -51.11 APE12-dist-in 13.3021 APE11-dist-in 11.6241 APE10-dist-in 6.0228 APE9-dist-in 3.4997 C44N,C53R,K86A,C222N,K237A None None XRAY 2.15 0.221 0.281 A 307.0 287.0 10 25 25 0 [[9, 293]] 1.0 8u2o Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.3e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CMGC PK6 Q8IDW1_PLAF7 8U2OB Q8IDW1 4 294 305.0 V3O:60405 Type1 Inactive DFGin 5.8335 12.5651 None -95.64, -148.11 -40.43, 130.23 -98.6, 12.15 305.65, 177.87 -65.69, -13.43 in-in in 9.5275 Saltbr-in 2.6266 HRD-in -80.22, -50.28 65.88, 13.5 in-in-out SNCiio in-out ActLoopNT-in 2.8247 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -75.1, -40.16 APE9-dihe-na -65.58, 130.1 APE8-dihe-in -62.82, 145.01 APE8-rot-out 89.31 APE67-dihe-in -59.91, -27.62 -49.15, -51.42 APE12-dist-in 13.4102 APE11-dist-in 11.7273 APE10-dist-in 6.0201 APE9-dist-in 3.4878 C44N,C53R,K86A,C222N,K237A None None XRAY 2.15 0.221 0.281 B 307.0 276.0 15 25 25 0 [[9, 293]] 1.0 8u2o Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.3e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CAMK CAMK1 KCC1A_RAT 1A06A Q63450 10 316 374.0 No_ligand No_ligand Inactive DFGin 8.5304 16.8416 None -78.3, -91.42 -50.6, 142.58 -174.46, 999.0 235.15, 89.5 999.0, 999.0 out-out out 12.8717 Saltbr-out 7.404 HRD-in -69.28, -53.46 75.23, -43.11 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -58.93, -19.88 999.0, -121.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.201 0.313 A 332.0 279.0 28 27 9 18 [[20, 276]] 1.0 1a06 Rattus norvegicus CAMK_CAMK1_RAT CAMK 7e-97 329.9 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK MARK2 MARK2_RAT 2R0IA O08679 48 363 722.0 No_ligand No_ligand Inactive DFGin 7.1773 15.9104 None -110.07, 163.19 70.79, 104.32 -114.32, 999.0 271.35, 82.41 999.0, 999.0 in-in in 9.8103 Saltbr-in 2.9222 HRD-in -72.72, -53.9 78.71, -16.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 32.87 APE8-dihe-out -80.28, -35.43 APE8-rot-out 33.61 APE67-dihe-in -54.73, -18.4 -55.05, -40.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5684 E318A None None XRAY 2.202 0.194 0.239 A 327.0 300.0 16 27 11 16 [[53, 304]] 1.0 2r0i Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2R0IB O08679 48 363 722.0 No_ligand No_ligand Inactive DFGin 7.288 15.7457 None -106.65, 164.03 58.05, 102.65 -104.54, 999.0 278.98, 72.06 999.0, 999.0 in-in in 9.6682 Saltbr-in 3.0026 HRD-in -63.83, -55.97 76.75, -7.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 34.5 APE8-dihe-out -80.07, -37.66 APE8-rot-out 40.75 APE67-dihe-in -61.42, -16.77 -41.08, -47.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.655 E318A None None XRAY 2.202 0.194 0.239 B 327.0 300.0 16 27 11 16 [[53, 304]] 1.0 2r0i Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2WZJA O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.2964 19.4429 None -98.71, 167.47 67.78, 27.22 -75.76, -39.27 231.0, 117.88 -107.13, -80.77 out-none out 11.1414 Saltbr-none 999.0 HRD-in -75.15, -47.64 70.01, -6.03 none-out-out SNCnoo out-out ActLoopNT-out 13.503 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -55.72, 133.56 APE9-dihe-na 78.12, -13.87 APE8-dihe-out -67.74, -43.04 APE8-rot-in 291.97 APE67-dihe-in -62.19, -15.93 -58.96, -43.73 APE12-dist-out 17.5862 APE11-dist-out 15.426 APE10-dist-out 16.7267 APE9-dist-out 10.8809 K82R,T208E None None XRAY 2.786 0.182 0.246 A 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2WZJB O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.655 19.1179 None -108.74, 166.92 70.33, 31.17 -81.88, -31.63 237.8, 118.28 -103.58, -84.38 out-none out 11.2946 Saltbr-none 999.0 HRD-in -73.51, -48.16 74.26, -7.23 none-out-out SNCnoo out-out ActLoopNT-out 13.3405 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -55.83, 119.56 APE9-dihe-na 97.8, -31.81 APE8-dihe-out -52.01, -40.59 APE8-rot-in 301.14 APE67-dihe-in -59.16, -17.79 -69.83, -40.48 APE12-dist-out 17.7834 APE11-dist-out 15.6951 APE10-dist-out 17.0451 APE9-dist-out 10.6569 K82R,T208E None None XRAY 2.786 0.182 0.246 B 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2WZJE O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.7278 19.4523 None -122.21, 167.3 70.37, 14.54 -64.86, -52.55 239.49, 125.08 -92.23, -103.55 out-none out 11.2743 Saltbr-none 999.0 HRD-in -71.5, -43.46 73.23, -7.58 none-out-out SNCnoo out-out ActLoopNT-out 13.576 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -54.24, 120.43 APE9-dihe-na 88.28, -0.67 APE8-dihe-out -78.27, -40.76 APE8-rot-in 286.92 APE67-dihe-in -59.78, -9.34 -58.65, -47.75 APE12-dist-out 18.0861 APE11-dist-out 15.9972 APE10-dist-out 17.2602 APE9-dist-out 11.1331 K82R,T208E None None XRAY 2.786 0.182 0.246 E 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2WZJF O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.4161 19.3297 None -128.0, 171.74 60.39, 39.11 -82.16, -33.66 235.83, 116.83 -109.02, -81.73 out-none out 11.4062 Saltbr-none 999.0 HRD-in -70.32, -50.59 74.66, -7.6 none-out-out SNCnoo out-out ActLoopNT-out 13.3181 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -47.39, 112.51 APE9-dihe-na 95.61, -12.53 APE8-dihe-out -65.97, -50.18 APE8-rot-in 297.4 APE67-dihe-in -68.54, -20.61 -50.47, -43.86 APE12-dist-out 17.1694 APE11-dist-out 15.1773 APE10-dist-out 16.4228 APE9-dist-out 10.9122 K82R,T208E None None XRAY 2.786 0.182 0.246 F 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK PRKAA1 AAPK1_RAT 4CFHA P54645 21 481 559.0 STU:61550 Type1 Inactive DFGin 6.6088 14.765 None -117.21, -79.88 -80.17, 112.56 -105.2, 27.91 278.75, 78.83 -62.93, -29.8 in-in in 9.2938 Saltbr-in 2.6645 HRD-out -123.7, 94.84 -71.28, 163.89 in-in-out SNCiio in-out ActLoopNT-in 3.0286 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -124.99, -9.44 APE9-dihe-na -61.07, -171.7 APE8-dihe-in -76.22, 167.06 APE8-rot-in 301.11 APE67-dihe-out -88.03, -177.87 -58.32, -48.27 APE12-dist-in 8.3547 APE11-dist-in 10.8638 APE10-dist-in 5.2822 APE9-dist-out 6.0779 None TPO183,TPO388 TPO183,TPO388 XRAY 3.24 0.234 0.268 A 493.0 402.0 0 27 27 0 [[27, 279]] 1.0 4cfh Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5KQ5A P54645 21 559 559.0 STU:60601,6VT:60602 Type1,Allosteric Inactive DFGin 7.4725 14.6042 None -132.46, -37.52 -94.52, 85.46 -82.34, 16.94 281.45, 80.99 -67.49, -33.4 in-in in 9.8975 Saltbr-in 3.2515 HRD-out -71.96, 95.28 -74.85, 167.58 in-in-out SNCiio in-out ActLoopNT-in 2.8817 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -101.64, 146.06 APE9-dihe-na 119.59, 166.41 APE8-dihe-in -64.65, 139.74 APE8-rot-out 166.73 APE67-dihe-in -69.09, -28.51 -58.99, -33.91 APE12-dist-in 7.8697 APE11-dist-in 11.3589 APE10-dist-in 5.426 APE9-dist-out 6.0759 None TPO183 TPO183 XRAY 3.41 0.223 0.259 A 503.0 363.0 0 27 27 0 [[27, 279]] 1.0 5kq5 Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CMGC MAPK1 MK01_RAT 6FJZA P63086 9 354 358.0 DKW:402 Type1 Inactive DFGin 6.6634 16.4202 None -134.8, -179.27 82.46, -86.27 66.98, 18.08 291.18, 83.08 -68.21, -20.47 in-in in 9.2842 Saltbr-in 2.7213 HRD-in -71.29, -49.89 75.9, -0.67 in-in-out SNCiio in-out ActLoopNT-in 2.7431 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -99.27, -45.48 APE9-dihe-na -54.12, 158.83 APE8-dihe-in -55.9, 129.11 APE8-rot-in 307.1 APE67-dihe-in -60.37, -17.39 -59.77, -49.92 APE12-dist-out 14.2719 APE11-dist-in 11.2255 APE10-dist-in 7.301 APE9-dist-in 4.4081 None None CME159 XRAY 1.864 0.174 0.207 A 364.0 346.0 0 31 31 0 [[23, 311]] 1.0 6fjz Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CAMK RAD53 RAD53_YEAST 5XZVA P22216 16 465 821.0 ANP:60501 ATPlike Inactive DFGin 7.0643 15.2612 None -121.2, -53.4 -91.08, 125.25 -116.1, 93.37 279.98, 81.22 -112.86, 58.45 in-out in 9.8831 Saltbr-out 4.1817 HRD-out -106.71, 124.14 -85.03, 170.27 out-out-none SNCoon out-none ActLoopNT-out 5.5013 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.22, -40.45 999.0, 55.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.273 0.289 A 471.0 375.0 42 27 13 14 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK SNF1 SNF1_YEAST 3HYHA P06782 54 315 633.0 No_ligand No_ligand Inactive DFGin 6.0984 16.7656 None -111.12, -13.11 -126.17, -61.58 79.91, 6.5 296.33, 106.43 140.74, -39.38 in-out in 9.3906 Saltbr-out 7.4467 HRD-in -72.58, -57.94 75.21, 1.42 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.98, -16.07 999.0, -51.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.241 0.28 A 275.0 238.0 24 27 12 15 [[55, 306]] 1.0 3hyh Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 6.9e-92 313.3 1.0 256.0 256.0 194 195 196 198 200 84 103 107 174 176 175 177.0 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
CAMK SNF1 SNF1_YEAST 3HYHB P06782 54 315 633.0 No_ligand No_ligand Inactive DFGin 5.4319 16.1058 None -106.08, -19.55 -134.22, -49.92 72.17, 2.2 308.78, 105.92 154.63, -57.75 in-out in 9.2973 Saltbr-out 9.3361 HRD-in -71.53, -49.18 67.86, -7.04 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.94, -15.46 999.0, -20.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.241 0.28 B 275.0 233.0 29 27 12 15 [[55, 306]] 1.0 3hyh Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 6.9e-92 313.3 1.0 256.0 256.0 194 195 196 198 200 84 103 107 174 176 175 177.0 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
CAMK SNF1 SNF1_YEAST 3DAEA P06782 48 315 633.0 No_ligand No_ligand Inactive DFGin 6.2177 16.202 None -125.2, -22.46 -94.07, -93.42 89.8, 999.0 293.71, 96.49 999.0, 999.0 in-out in 8.8598 Saltbr-out 6.4233 HRD-in -64.28, -60.04 81.75, -19.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 169.41 APE8-dihe-in -109.2, 134.01 APE8-rot-out 65.28 APE67-dihe-in -77.3, -18.85 -73.8, -6.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9096 None None None XRAY 2.899 0.229 0.265 A 283.0 248.0 20 27 11 16 [[55, 306]] 1.0 3dae Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 7.7e-92 313.1 1.0 256.0 256.0 194 195 196 198 200 84 103 107 174 176 175 177.0 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
CAMK SNF1 SNF1_YEAST 3DAEB P06782 50 315 633.0 No_ligand No_ligand Inactive DFGin 6.3629 15.9617 None -127.08, -17.05 -95.64, -97.19 92.94, 999.0 297.43, 95.41 999.0, 999.0 in-out in 8.9693 Saltbr-out 7.3816 HRD-in -71.27, -60.85 84.49, -11.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 93.59 APE8-dihe-in -114.5, 143.48 APE8-rot-out 65.27 APE67-dihe-in -79.74, -11.6 -115.06, 12.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1443 None None None XRAY 2.899 0.229 0.265 B 283.0 246.0 20 27 11 16 [[55, 306]] 1.0 3dae Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 7.7e-92 313.1 1.0 256.0 256.0 194 195 196 198 200 84 103 107 174 176 175 177.0 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
OTHER PAN3-12 PAN3_YEAST 4XR7B P36102 226 679 679.0 No_ligand No_ligand Pseudo DFGin 8.5025 15.4217 None -104.85, -81.9 -55.51, -45.21 62.67, 17.87 199.85, 999.0 45.47, 46.6 out-na out 13.4903 Saltbr-na 999.0 HRD-out -76.12, -16.46 -97.99, 85.58 na-out-na SNCaoa out-na ActLoopNT-out 8.9448 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.19, 130.31 APE9-dihe-na -74.85, 162.0 APE8-dihe-na -74.39, -32.88 APE8-rot-na 188.94 APE67-dihe-na -124.14, 114.63 -58.03, 146.49 APE12-dist-na 11.2874 APE11-dist-na 13.8798 APE10-dist-na 13.5452 APE9-dist-na 21.3537 None None None XRAY 3.796 0.286 0.299 B 465.0 427.0 8 21 18 3 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7E P36102 252 679 679.0 No_ligand No_ligand Pseudo DFGin 8.5933 14.5451 None -105.54, -82.28 -61.73, -45.08 66.71, 24.92 201.84, 999.0 57.11, 56.18 out-na out 12.9797 Saltbr-na 999.0 HRD-out -76.76, -25.26 -92.98, 20.24 na-out-na SNCaoa out-na ActLoopNT-out 8.9533 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -151.67, 137.7 APE9-dihe-na -156.27, 147.39 APE8-dihe-na 50.58, -115.32 APE8-rot-na 999.0 APE67-dihe-na -120.31, 161.36 -52.5, 149.39 APE12-dist-na 10.4227 APE11-dist-na 14.3995 APE10-dist-na 13.0607 APE9-dist-na 22.1966 None None None XRAY 3.796 0.286 0.299 E 465.0 414.0 14 21 17 4 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7F P36102 228 679 679.0 No_ligand No_ligand Pseudo DFGin 7.3351 13.9922 None -85.2, -83.41 -116.11, 146.78 -89.94, 10.94 48.78, 999.0 50.83, 40.11 out-na out 14.008 Saltbr-na 999.0 HRD-out -81.05, -16.69 -95.9, 8.11 na-out-na SNCaoa out-na ActLoopNT-out 9.4022 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -60.89, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 14.4938 APE11-dist-na 13.2541 APE10-dist-na 14.3861 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 F 465.0 442.0 10 21 12 9 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7H P36102 250 679 679.0 No_ligand No_ligand Pseudo DFGin 8.6796 13.3004 None -110.24, -81.52 -76.76, -38.07 62.46, 20.88 310.53, 999.0 54.16, 56.32 out-na out 12.9207 Saltbr-na 999.0 HRD-out -76.61, -35.33 -92.88, 18.01 na-out-na SNCaoa out-na ActLoopNT-out 8.4985 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.22, 105.17 APE9-dihe-na -135.67, 109.97 APE8-dihe-na -101.57, -1.61 APE8-rot-na 999.0 APE67-dihe-na -115.02, 104.33 50.65, 25.81 APE12-dist-na 10.2 APE11-dist-na 15.2541 APE10-dist-na 16.0733 APE9-dist-na 20.3565 None None None XRAY 3.796 0.286 0.299 H 465.0 420.0 10 21 21 0 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7I P36102 229 679 679.0 No_ligand No_ligand Pseudo DFGin 8.1436 12.4336 None -108.56, -80.67 -51.19, -43.4 36.07, 999.0 50.25, 999.0 999.0, 999.0 out-na out 13.8264 Saltbr-na 999.0 HRD-out -73.52, 162.17 61.84, 30.5 na-out-na SNCaoa out-na ActLoopNT-out 8.9846 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 14.2752 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 I 465.0 437.0 14 21 9 12 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7K P36102 232 679 679.0 No_ligand No_ligand Pseudo DFGin 8.8667 14.9228 None -156.42, 150.14 71.91, -27.38 40.67, 30.2 203.09, 999.0 55.41, 54.89 out-na out 12.9021 Saltbr-na 999.0 HRD-out -76.01, -11.95 -99.49, 85.37 na-out-na SNCaoa out-na ActLoopNT-out 9.2524 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -146.25, 136.7 APE9-dihe-na -119.48, 142.98 APE8-dihe-na -86.15, 136.33 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 -173.56, 999.0 APE12-dist-na 10.2176 APE11-dist-na 14.3981 APE10-dist-na 13.3286 APE9-dist-na 21.6671 None None None XRAY 3.796 0.286 0.299 K 465.0 430.0 12 21 15 6 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7L P36102 228 679 679.0 No_ligand No_ligand Pseudo DFGin 6.6712 13.6853 None -78.56, -72.57 -129.25, 151.61 -94.17, 11.47 47.53, 999.0 54.98, 49.56 out-na out 13.8368 Saltbr-na 999.0 HRD-out -78.34, 152.76 -93.5, 19.59 na-out-na SNCaoa out-na ActLoopNT-out 9.6542 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 11.6156 APE11-dist-na 10.871 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 L 465.0 441.0 11 21 11 10 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 6R5KN P36102 226 679 679.0 No_ligand No_ligand Pseudo DFGin 8.4796 14.6642 None -120.3, -48.75 -78.43, -46.99 64.41, 6.24 198.56, 999.0 58.24, 31.07 out-na out 14.2569 Saltbr-na 999.0 HRD-out -118.35, -63.98 -77.29, 95.53 na-out-na SNCaoa out-na ActLoopNT-out 10.6477 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -133.92, 86.09 APE9-dihe-na -148.85, 91.9 APE8-dihe-na 67.7, -5.31 APE8-rot-na 203.89 APE67-dihe-na -67.7, 108.58 -85.15, -39.73 APE12-dist-na 11.0066 APE11-dist-na 11.8723 APE10-dist-na 10.2258 APE9-dist-na 14.9417 None None None EM 4.8 999.0 999.0 N 458.0 427.0 8 21 18 3 [[284, 397], [394, 557]] 2.0 6r5k Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 3.6e-11 78.1 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 6R5KO P36102 224 679 679.0 No_ligand No_ligand Pseudo DFGin 10.4578 15.6741 None -78.53, -48.76 -98.61, 103.36 -129.36, 83.07 293.03, 999.0 -139.53, -162.35 out-na out 14.0111 Saltbr-na 999.0 HRD-out -70.33, -14.42 -118.0, -56.77 na-out-na SNCaoa out-na ActLoopNT-out 12.3551 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None EM 4.8 999.0 999.0 O 689.0 443.0 13 21 9 12 [[284, 397], [394, 557]] 2.0 6r5k Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 2.8e-11 77.9 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PINK1 PINK1_TRICA 7MP9A D6WMX4 121 568 570.0 AN2:609 ATPlike Inactive DFGin 9.4917 15.077 None -107.5, -68.6 -79.29, 107.71 -103.85, 17.12 271.24, 68.18 -70.55, -9.3 in-in in 7.8201 Saltbr-in 2.482 HRD-in -85.61, -44.31 63.96, 13.98 in-in-in SNCiii in-in ActLoopNT-in 2.7063 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 122.7, -149.63 APE9-dihe-na -104.04, -111.12 APE8-dihe-in -65.26, 151.5 APE8-rot-na 80.98 APE67-dihe-in -70.22, -49.9 -101.67, -4.86 APE12-dist-in 7.9325 APE11-dist-in 10.2637 APE10-dist-in 5.6129 APE9-dist-in 3.4397 None SEP205,TPO530 SEP205,TPO530 XRAY 2.8 0.25 0.306 A 455.0 414.0 31 34 34 0 [[61, 504]] 1.0 7mp9 Tribolium castaneum OTHER_PINK1_TRICA PINK1 3.5e-89 305.2 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_TRICA 8UDCA D6WMX4 122 566 570.0 WCK:603 Type1 Inactive DFGin 9.4017 14.9712 None -109.71, -75.95 -80.82, 116.53 -96.35, 38.57 282.73, 77.17 -65.86, -41.7 in-out in 7.7561 Saltbr-out 3.8176 HRD-in -84.54, -42.39 69.78, -6.1 out-in-out SNCoio in-out ActLoopNT-in 2.8586 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iiii APE10-dihe-na 116.87, 89.91 APE9-dihe-na -31.69, 140.62 APE8-dihe-out 95.57, 105.05 APE8-rot-na 175.25 APE67-dihe-in -73.73, -57.88 -95.91, -8.92 APE12-dist-in 7.2371 APE11-dist-in 10.1192 APE10-dist-in 5.5867 APE9-dist-in 4.9123 W131A,W142A,Y144A,I147A,Y225A,Y378A,F401A,F437A None None XRAY 3.1 0.259 0.329 A 455.0 397.0 30 34 34 0 [[61, 504]] 1.0 8udc Tribolium castaneum OTHER_PINK1_TRICA PINK1 1.6e-89 306.3 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_TRICA 8UCTA D6WMX4 122 566 570.0 3YT:604 Type1 Inactive DFGin 9.6675 15.5149 None -106.46, -71.46 -86.94, 98.04 -82.78, 26.92 282.15, 73.59 -69.21, -17.85 in-in in 7.7276 Saltbr-in 3.5456 HRD-in -61.61, -52.71 76.55, -7.29 in-in-in SNCiii in-in ActLoopNT-in 2.8231 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 143.12, -153.91 APE9-dihe-na -114.43, -90.54 APE8-dihe-in -52.28, 116.57 APE8-rot-na 181.23 APE67-dihe-in -80.32, -30.67 -78.6, -18.94 APE12-dist-in 7.6852 APE11-dist-in 9.8751 APE10-dist-in 5.4884 APE9-dist-in 4.262 W131A,W142A,Y225A,Y378A,F401A,F437A None None XRAY 2.93 0.284 0.305 A 455.0 391.0 37 34 34 0 [[61, 504]] 1.0 8uct Tribolium castaneum OTHER_PINK1_TRICA PINK1 1.6e-89 306.3 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
AGC TB0348O8470 Q582V7_TRYB2 9Z8KA Q582V7 54 348 406.0 No_ligand No_ligand Inactive DFGin 8.1173 13.0625 None -69.43, 156.83 -45.73, 116.64 -72.04, -20.66 74.88, 86.04 -64.59, -37.41 in-out in 9.806 Saltbr-out 6.7036 HRD-in -68.62, -41.79 73.54, -21.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.78 APE8-dihe-out -53.88, -45.48 APE8-rot-out 194.69 APE67-dihe-in -78.28, -17.05 -56.7, -29.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2459 None SEP71 SEP71 XRAY 2.05 0.197 0.235 A 362.0 272.0 23 37 14 23 [[61, 326]] 1.0 9z8k Trypanosoma brucei brucei AGC_TB0348O8470_TRYB2 AGC 3.9e-77 264.9 1.0 259.0 259.0 203 204 205 207 209 90 109 113 183 185 184 186.0 252 240 235 234 233 232 231 230 229 139 Serine/threonine-protein kinase, putative
CAMK AURKBA AUKBA_XENLA 4B8LA Q6DE08 87 351 361.0 A0P:1352 Type1 Inactive DFGin 7.5521 15.5639 None -81.6, -93.69 -89.24, 141.54 -107.67, 999.0 288.18, 65.55 999.0, 999.0 out-out out 10.5609 Saltbr-out 5.9445 HRD-in -91.78, -45.75 80.25, -35.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.01 APE8-rot-in 294.25 APE67-dihe-in -54.23, -29.34 -30.25, -64.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P353G None None XRAY 3.0 0.24 0.297 A 286.0 249.0 16 26 10 16 [[93, 343]] 1.0 4b8l Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.6e-77 265.6 1.0 256.0 256.0 233 234 235 237 239 122 141 145 213 215 214 216.0 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A

All / DFGinNone / All

Total number of chains: 182
Active chains: 0
Total number of genes: 39
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 182 100.0% 6FJZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK SRK2E SRK2E_ARATH 3ZUTA Q940H6 10 319 362.0 No_ligand No_ligand Inactive DFGin 5.3431 15.9671 None -75.48, 118.83 -107.6, 133.45 62.39, 58.1 305.8, 109.47 -67.41, -20.08 out-out out 10.5718 Saltbr-out 10.0563 HRD-out 58.97, -113.21 -49.76, -30.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -152.15 APE8-dihe-in -81.19, 135.09 APE8-rot-out 177.58 APE67-dihe-in -54.58, -33.26 -62.82, -9.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6696 D160A None None XRAY 2.5 0.2 0.251 A 362.0 281.0 14 27 13 14 [[21, 277]] 1.0 3zut Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 6.2e-78 267.7 1.0 256.0 256.0 159 160 161 163 165 50 65 69 137 139 138 140.0 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3ZUTB Q940H6 12 319 362.0 No_ligand No_ligand Inactive DFGin 4.8762 15.3954 None -75.3, 124.36 -115.8, 127.7 65.47, 106.61 311.96, 114.27 -98.96, -3.88 out-out out 10.6176 Saltbr-out 9.3839 HRD-out 62.27, -110.47 -69.62, -9.25 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -85.82, 129.48 APE9-dihe-na -121.55, 97.96 APE8-dihe-in -66.22, 140.7 APE8-rot-out 171.28 APE67-dihe-in -64.23, -22.2 -68.96, 1.14 APE12-dist-out 15.6846 APE11-dist-out 15.3207 APE10-dist-out 20.4461 APE9-dist-out 13.4818 D160A None None XRAY 2.5 0.2 0.251 B 362.0 282.0 11 27 16 11 [[21, 277]] 1.0 3zut Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 6.2e-78 267.7 1.0 256.0 256.0 159 160 161 163 165 50 65 69 137 139 138 140.0 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3ZUUA Q940H6 10 319 362.0 No_ligand No_ligand Inactive DFGin 5.0518 15.7399 None -78.02, 121.88 -112.13, 123.32 74.86, 129.63 308.4, 109.53 -113.78, -23.24 out-out out 10.7083 Saltbr-out 10.9251 HRD-out 60.19, -109.28 -73.61, -9.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -131.12 APE8-dihe-in -66.07, 126.24 APE8-rot-out 190.15 APE67-dihe-in -49.46, -40.23 -66.38, -5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7083 None None None XRAY 2.7 0.24 0.279 A 362.0 281.0 14 27 13 14 [[21, 277]] 1.0 3zuu Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 4.8e-78 268.1 1.0 256.0 256.0 159 160 161 163 165 50 65 69 137 139 138 140.0 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3ZUUB Q940H6 12 319 362.0 No_ligand No_ligand Inactive DFGin 6.1213 15.9199 None -83.59, 133.25 -127.99, 121.87 66.13, 107.74 301.29, 137.89 -97.8, 10.76 out-out out 10.69 Saltbr-out 8.3952 HRD-out 64.51, -102.84 -87.26, 3.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -86.09, 125.1 APE9-dihe-na -111.04, 114.67 APE8-dihe-in -75.16, 145.3 APE8-rot-out 177.67 APE67-dihe-in -53.2, -27.17 -65.59, -13.68 APE12-dist-out 16.2308 APE11-dist-out 16.0914 APE10-dist-out 20.7482 APE9-dist-out 13.521 None None None XRAY 2.7 0.24 0.279 B 362.0 282.0 11 27 16 11 [[21, 277]] 1.0 3zuu Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 4.8e-78 268.1 1.0 256.0 256.0 159 160 161 163 165 50 65 69 137 139 138 140.0 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2I SRK2I_ARATH 3UC3A Q39193 11 319 361.0 No_ligand No_ligand Inactive DFGin 4.2938 12.7917 None -145.36, 92.51 -115.24, 12.18 -77.52, 136.51 307.6, 104.69 -78.46, 76.71 out-out out 10.8037 Saltbr-out 12.1133 HRD-out 54.11, 56.86 -98.01, 161.99 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.06, -25.34 999.0, -53.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D57A,K58A None None XRAY 1.9 0.214 0.23 A 361.0 272.0 19 27 12 15 [[22, 278]] 1.0 3uc3 Arabidopsis thaliana CAMK_SRK2I_ARATH CAMK 7.3e-78 267.4 1.0 256.0 256.0 160 161 162 164 166 51 66 70 138 140 139 141.0 200 187 182 181 180 179 178 177 176 96 Serine/threonine-protein kinase SRK2I
CMGC MPK6 MPK6_ARATH 6DTLB Q39026 33 395 395.0 No_ligand No_ligand Inactive DFGin 6.3694 16.39 None -148.48, 175.65 63.21, 53.93 -61.36, -70.15 305.75, 86.78 64.05, -152.3 in-out in 9.5866 Saltbr-out 4.4225 HRD-in -78.54, -47.34 74.03, -15.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -115.48, -39.06 APE9-dihe-na -70.2, 153.86 APE8-dihe-in -65.87, 121.66 APE8-rot-out 82.86 APE67-dihe-in -63.98, -8.94 -96.81, 19.77 APE12-dist-out 14.5191 APE11-dist-out 17.816 APE10-dist-out 17.246 APE9-dist-out 11.6073 None None None XRAY 2.753 0.209 0.256 B 364.0 357.0 6 27 21 6 [[64, 348]] 1.0 6dtl Arabidopsis thaliana CMGC_MPK6_ARATH CMGC 9.1e-83 284.1 5.0 301.0 297.0 206 207 208 210 212 92 110 114 186 188 187 189.0 246 233 228 227 226 225 224 223 222 145 Mitogen-activated protein kinase 6
STE MKK5 M2K5_ARATH 7XBRB Q8RXG3 65 328 348.0 No_ligand No_ligand Inactive DFGin 6.681 13.8877 None -121.61, -96.16 -63.34, 129.84 -113.98, 24.72 285.0, 121.79 -65.45, -12.08 in-in in 9.3493 Saltbr-in 3.1011 HRD-in -84.14, -49.25 70.89, 8.88 in-in-in SNCiii in-in ActLoopNT-in 3.0418 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.21, 159.6 APE9-dihe-na 105.31, -157.61 APE8-dihe-in -100.67, 121.86 APE8-rot-in 310.05 APE67-dihe-in -60.6, -31.14 -55.32, -44.58 APE12-dist-in 8.1 APE11-dist-in 10.8482 APE10-dist-in 4.9358 APE9-dist-in 3.7194 None SEP66,TPO83,TPO108,TPO215,SEP221 SEP66,TPO83,TPO108,TPO215,SEP221 XRAY 3.2 0.211 0.246 B 295.0 258.0 6 28 28 0 [[70, 325]] 1.0 7xbr Arabidopsis thaliana STE_MKK5_ARATH STE 2e-67 233.2 2.0 257.0 256.0 204 205 206 208 210 99 116 120 184 186 185 187.0 249 232 227 226 225 224 223 222 221 146 Mitogen-activated protein kinase kinase 5
STE MKK5 M2K5_ARATH 7XBRE Q8RXG3 65 328 348.0 No_ligand No_ligand Inactive DFGin 6.5348 14.1017 None -120.22, -97.1 -62.38, 127.72 -111.99, 20.18 283.79, 119.37 -67.64, -29.46 in-in in 9.3343 Saltbr-in 2.8783 HRD-in -89.83, -47.23 59.75, 5.43 in-in-out SNCiio in-out ActLoopNT-in 3.0713 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.46, 164.72 APE9-dihe-na 97.44, -159.58 APE8-dihe-in -119.77, 136.97 APE8-rot-out 62.89 APE67-dihe-in -70.07, -10.3 -69.6, -34.62 APE12-dist-in 8.133 APE11-dist-in 10.7875 APE10-dist-in 4.8252 APE9-dist-in 3.69 None SEP66,TPO83,TPO108,TPO215,SEP221 SEP66,TPO83,TPO108,TPO215,SEP221 XRAY 3.2 0.211 0.246 E 295.0 258.0 6 28 28 0 [[70, 325]] 1.0 7xbr Arabidopsis thaliana STE_MKK5_ARATH STE 2e-67 233.2 2.0 257.0 256.0 204 205 206 208 210 99 116 120 184 186 185 187.0 249 232 227 226 225 224 223 222 221 146 Mitogen-activated protein kinase kinase 5
STE MKK5 M2K5_ARATH 7XBRG Q8RXG3 64 327 348.0 No_ligand No_ligand Inactive DFGin 6.5283 13.6785 None -119.49, -98.14 -64.68, 127.04 -110.22, 19.61 289.02, 116.07 -60.03, -30.61 in-in in 9.4073 Saltbr-in 2.6634 HRD-in -78.13, -40.26 64.7, 6.49 in-in-out SNCiio in-out ActLoopNT-in 2.9109 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.47, 168.52 APE9-dihe-na 124.73, -147.31 APE8-dihe-in -121.15, 133.96 APE8-rot-out 51.88 APE67-dihe-in -73.53, -7.48 -67.23, -41.05 APE12-dist-in 8.3439 APE11-dist-in 11.1487 APE10-dist-in 5.7652 APE9-dist-in 3.8869 None SEP66,TPO83,TPO108,TPO215,SEP221 SEP66,TPO83,TPO108,TPO215,SEP221 XRAY 3.2 0.211 0.246 G 295.0 258.0 6 28 28 0 [[70, 325]] 1.0 7xbr Arabidopsis thaliana STE_MKK5_ARATH STE 2e-67 233.2 2.0 257.0 256.0 204 205 206 208 210 99 116 120 184 186 185 187.0 249 232 227 226 225 224 223 222 221 146 Mitogen-activated protein kinase kinase 5
TKL BAK1 BAK1_ARATH 3TL8G Q94F62 274 578 615.0 No_ligand No_ligand Inactive DFGin 8.7047 15.9151 None -150.19, 66.97 -163.48, 93.86 -92.58, 25.32 292.66, 75.26 -62.11, -33.44 in-in in 8.7844 Saltbr-in 3.4207 HRD-in -73.16, -36.65 62.39, 3.46 in-in-in SNCiii in-in ActLoopNT-in 2.8368 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.06, 156.98 APE9-dihe-na 140.13, -161.91 APE8-dihe-in -117.12, 124.4 APE8-rot-in 293.18 APE67-dihe-inflip 101.45, -17.86 -52.66, 132.04 APE12-dist-in 9.9101 APE11-dist-in 11.2463 APE10-dist-in 5.6222 APE9-dist-in 3.5732 None TPO324,TPO446,TPO449,TPO450 TPO324,TPO446,TPO449,TPO450 XRAY 2.5 0.186 0.238 G 349.0 305.0 0 29 29 0 [[288, 565]] 1.0 3tl8 Arabidopsis thaliana TKL_BAK1_ARATH TKL 7.4e-64 221.9 4.0 266.0 263.0 433 434 435 437 439 317 334 338 413 415 414 416.0 474 462 457 456 455 454 453 452 451 364 BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
TKL BIK1 BIK1_ARATH 5TOSA O48814 52 360 395.0 No_ligand No_ligand Inactive DFGin 6.0802 15.0127 None -62.74, 167.28 -56.72, 147.4 -146.31, 147.51 60.48, 95.84 -80.41, 175.54 out-out out 13.9695 Saltbr-out 11.28 HRD-in -75.04, -37.7 71.23, -32.33 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 113.76, -29.94 999.0, 116.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP253 SEP253 XRAY 2.35 0.239 0.268 A 395.0 280.0 29 30 11 19 [[63, 351]] 1.0 5tos Arabidopsis thaliana TKL_BIK1_ARATH TKL 5.7e-62 215.8 5.0 266.0 262.0 219 220 221 223 225 105 121 125 199 201 200 202.0 261 249 244 243 242 241 240 239 238 151 Serine/threonine-protein kinase BIK1
TKL BIK1 BIK1_ARATH 5TOSB O48814 52 360 395.0 No_ligand No_ligand Inactive DFGin 6.4974 15.2276 None -63.36, 165.7 -58.85, 147.51 -147.14, 147.16 60.84, 95.51 -81.76, 173.49 out-out out 14.0407 Saltbr-out 11.374 HRD-in -74.69, -37.3 70.98, -32.38 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 113.36, -30.28 999.0, 117.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP253 SEP253 XRAY 2.35 0.239 0.268 B 395.0 280.0 29 30 11 19 [[63, 351]] 1.0 5tos Arabidopsis thaliana TKL_BIK1_ARATH TKL 5.7e-62 215.8 5.0 266.0 262.0 219 220 221 223 225 105 121 125 199 201 200 202.0 261 249 244 243 242 241 240 239 238 151 Serine/threonine-protein kinase BIK1
TKL CARK1 CARK1_ARATH 5XD6A Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.2866 13.9895 None -82.23, -179.6 -66.2, 154.72 -113.7, 177.91 45.1, 88.76 -91.38, 112.57 out-na out 13.41 Saltbr-na 13.4762 HRD-in -67.99, -48.34 77.3, -6.84 na-out-none SNCaon out-none ActLoopNT-out 8.2956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 12.83 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 A 305.0 278.0 23 30 13 17 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4.0 266.0 263.0 216 217 218 220 222 97 112 116 196 198 197 199.0 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL CARK1 CARK1_ARATH 5XD6B Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.6295 13.9302 None -77.44, -177.16 -70.67, 157.78 -117.63, 177.11 50.67, 89.87 -85.72, 109.22 out-na out 13.6757 Saltbr-na 14.0861 HRD-in -75.16, -46.81 74.28, -9.17 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -2.12 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 B 305.0 282.0 19 30 11 19 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4.0 266.0 263.0 216 217 218 220 222 97 112 116 196 198 197 199.0 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL CTR1 CTR1_ARATH 3P86B Q05609 543 810 821.0 No_ligand No_ligand Inactive DFGin 5.9967 12.0951 None -121.91, -1.76 -123.79, 154.13 -144.82, 999.0 328.24, 95.27 999.0, 999.0 in-out in 9.309 Saltbr-out 6.3165 HRD-in -67.98, -63.15 80.5, -8.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -98.93 APE8-dihe-in -139.16, 81.75 APE8-rot-out 49.11 APE67-dihe-in -63.86, -17.41 -93.9, 11.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0062 D676N None None XRAY 2.496 0.197 0.232 B 309.0 239.0 29 28 11 17 [[551, 807]] 1.0 3p86 Arabidopsis thaliana TKL_CTR1_ARATH TKL 3.2e-78 268.9 2.0 265.0 264.0 693 694 695 697 699 578 596 600 673 675 674 676.0 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
AGC GRK2 ARBK1_BOVIN 1OMWA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.448 13.0685 None -112.27, -91.9 -67.18, 126.78 -99.0, 7.24 286.96, 109.41 -44.09, -46.49 in-in in 8.9372 Saltbr-in 3.4107 HRD-in -73.22, -52.41 80.02, -28.79 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.71, 128.56 APE9-dihe-na 124.77, -168.54 APE8-dihe-in -89.28, 150.91 APE8-rot-in 295.71 APE67-dihe-in -77.59, -9.92 -72.81, -27.02 APE12-dist-in 10.5885 APE11-dist-in 11.8774 APE10-dist-in 6.1942 APE9-dist-in 3.5029 S670A None None XRAY 2.5 0.216 0.252 A 689.0 614.0 0 26 26 0 [[191, 453]] 1.0 1omw Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7A P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2239 12.3565 None -125.66, -66.29 -94.21, 107.11 -86.73, -10.11 307.87, 97.53 -38.26, -47.46 in-out in 8.8531 Saltbr-out 4.6372 HRD-in -74.94, -45.18 74.24, -26.22 out-in-in SNCoii in-in ActLoopNT-in 2.7715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.74, 123.21 APE9-dihe-na 155.55, 174.57 APE8-dihe-in -86.11, 141.22 APE8-rot-in 314.43 APE67-dihe-in -66.31, -34.76 -64.21, -27.3 APE12-dist-in 9.8313 APE11-dist-in 11.5432 APE10-dist-in 5.5926 APE9-dist-in 3.9926 S670A None None XRAY 4.5 0.226 0.279 A 689.0 608.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7C P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2163 12.2674 None -130.34, -66.38 -92.79, 106.85 -85.97, -13.2 309.12, 95.06 -35.96, -48.47 in-out in 8.8136 Saltbr-out 4.7358 HRD-in -75.86, -48.89 75.97, -29.41 out-in-in SNCoii in-in ActLoopNT-in 2.721 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.29, 128.8 APE9-dihe-na 145.96, 173.8 APE8-dihe-in -87.44, 141.12 APE8-rot-in 314.72 APE67-dihe-in -67.09, -36.43 -60.22, -25.52 APE12-dist-in 9.7747 APE11-dist-in 11.5691 APE10-dist-in 5.6074 APE9-dist-in 4.0582 S670A None None XRAY 4.5 0.226 0.279 C 689.0 607.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7D P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2341 12.3436 None -128.88, -67.33 -92.65, 105.41 -87.88, -10.71 307.83, 96.53 -37.49, -49.46 in-out in 8.801 Saltbr-out 4.7459 HRD-in -72.13, -45.13 72.62, -27.86 out-in-in SNCoii in-in ActLoopNT-in 2.7633 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.27, 125.22 APE9-dihe-na 149.39, 173.11 APE8-dihe-in -84.5, 141.69 APE8-rot-in 315.18 APE67-dihe-in -66.11, -35.98 -62.26, -27.83 APE12-dist-in 9.7362 APE11-dist-in 11.4974 APE10-dist-in 5.5333 APE9-dist-in 4.0286 S670A None None XRAY 4.5 0.226 0.279 D 689.0 599.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 2BCJA P21146 28 667 689.0 No_ligand No_ligand Inactive DFGin 5.1531 12.3754 None -114.23, -125.71 -23.26, 91.28 -81.33, 0.62 275.63, 158.44 -51.51, -42.54 in-in in 8.6198 Saltbr-in 2.6334 HRD-in -86.19, -45.87 70.94, -23.92 in-in-in SNCiii in-in ActLoopNT-in 2.7186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.73, 137.19 APE9-dihe-na 118.03, -177.98 APE8-dihe-in -75.0, 121.63 APE8-rot-in 302.92 APE67-dihe-in -97.57, -19.7 -76.89, 19.37 APE12-dist-in 11.0395 APE11-dist-in 11.9406 APE10-dist-in 6.0057 APE9-dist-in 3.715 S670A None None XRAY 3.061 0.236 0.292 A 689.0 624.0 0 26 26 0 [[191, 453]] 1.0 2bcj Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3UZSA P21146 29 671 689.0 No_ligand No_ligand Inactive DFGin 5.731 11.1485 None -107.21, -110.21 -68.72, 97.64 -52.38, -56.06 299.08, 3.09 42.56, -75.63 in-out in 9.0047 Saltbr-out 3.9207 HRD-in -77.33, -41.02 60.69, 32.77 out-in-out SNCoio in-out ActLoopNT-in 3.5286 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -98.18, 142.14 APE9-dihe-na 139.16, 169.96 APE8-dihe-in -74.03, 124.78 APE8-rot-in 315.02 APE67-dihe-out 166.07, -43.85 -59.08, 78.84 APE12-dist-in 10.2386 APE11-dist-in 12.0969 APE10-dist-in 6.31 APE9-dist-in 3.5138 S670A None None XRAY 4.52 0.188 0.268 A 689.0 609.0 20 26 26 0 [[191, 453]] 1.0 3uzs Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3UZTA P21146 30 656 689.0 No_ligand No_ligand Inactive DFGin 5.216 12.499 None -94.28, -95.77 -83.37, 90.84 -54.75, -37.85 271.69, 47.64 -2.65, -69.38 in-out in 8.8257 Saltbr-out 5.0807 HRD-in -72.79, -37.98 67.02, -27.54 out-in-in SNCoii in-in ActLoopNT-in 3.085 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.51, 148.65 APE9-dihe-na 138.76, 168.6 APE8-dihe-in -71.39, 126.55 APE8-rot-in 294.92 APE67-dihe-in -71.95, -17.71 -54.34, -25.29 APE12-dist-in 9.5328 APE11-dist-in 12.0098 APE10-dist-in 5.9885 APE9-dist-in 3.8685 S670A None None XRAY 3.51 0.22 0.317 A 689.0 586.0 12 26 26 0 [[191, 453]] 1.0 3uzt Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PSCA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.4842 12.8251 None -112.1, -116.4 -50.02, 128.26 -100.71, 13.15 287.53, 88.47 -45.02, -46.74 in-in in 8.8883 Saltbr-in 3.1136 HRD-in -73.4, -47.49 67.75, 0.38 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.59, 142.02 APE9-dihe-na 121.44, 174.37 APE8-dihe-in -79.3, 138.73 APE8-rot-in 323.05 APE67-dihe-in -80.94, 3.9 -61.06, -31.71 APE12-dist-in 10.1172 APE11-dist-in 11.7629 APE10-dist-in 5.9289 APE9-dist-in 3.1916 S670A None None XRAY 2.67 0.225 0.257 A 695.0 614.0 0 26 26 0 [[191, 453]] 1.0 3psc Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PVUA P21146 30 668 689.0 QRW:800 Type1 Inactive DFGin 5.4293 12.5496 None -114.2, -126.97 -29.78, 116.79 -95.83, 7.38 283.37, 161.7 -55.56, -22.85 in-in in 8.7486 Saltbr-in 2.9863 HRD-in -71.34, -46.23 80.59, -11.92 in-in-in SNCiii in-in ActLoopNT-in 2.9271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.26, 142.91 APE9-dihe-na 117.3, -165.9 APE8-dihe-in -102.62, 148.45 APE8-rot-in 314.0 APE67-dihe-in -77.54, 11.33 -67.23, -35.08 APE12-dist-in 10.2837 APE11-dist-in 11.8902 APE10-dist-in 6.1863 APE9-dist-in 3.4202 S670A None None XRAY 2.48 0.229 0.274 A 695.0 609.0 0 26 26 0 [[191, 453]] 1.0 3pvu Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PVWA P21146 29 668 689.0 QRX:800 Type1 Inactive DFGin 5.249 12.3972 None -104.93, -94.33 -60.0, 121.61 -95.37, 6.96 285.31, 4.38 -65.85, -19.47 in-in in 8.7495 Saltbr-in 3.07 HRD-in -69.01, -52.71 78.6, -13.88 in-in-in SNCiii in-in ActLoopNT-in 2.9188 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.25, 142.6 APE9-dihe-na 127.77, 176.65 APE8-dihe-in -84.9, 148.79 APE8-rot-in 327.3 APE67-dihe-in -77.16, 13.46 -65.86, -42.83 APE12-dist-in 10.7375 APE11-dist-in 12.1865 APE10-dist-in 6.4122 APE9-dist-in 3.337 S670A None None XRAY 2.49 0.239 0.285 A 695.0 613.0 0 26 26 0 [[191, 453]] 1.0 3pvw Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC PRKACA KAPCA_BOVIN 4C35A P00517 11 351 351.0 NU3:61351 Type1.5_Back Inactive DFGin 5.96 15.1175 None -103.23, -88.31 -54.39, 108.88 -97.56, 11.02 265.67, 64.27 -54.79, -37.29 in-in in 9.1847 Saltbr-in 2.7744 HRD-in -78.97, -53.39 72.53, 0.25 in-in-in SNCiii in-in ActLoopNT-in 2.8688 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.98, 158.62 APE9-dihe-na 121.3, -169.27 APE8-dihe-in -106.38, 130.41 APE8-rot-in 302.02 APE67-dihe-in -58.09, -26.56 -41.09, -54.15 APE12-dist-in 8.7429 APE11-dist-in 11.6126 APE10-dist-in 5.9626 APE9-dist-in 3.4271 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.19 0.186 0.24 A 351.0 341.0 0 25 25 0 [[44, 298]] 1.0 4c35 Bos taurus AGC_PRKACA_BOVIN AGC 7.8e-94 319.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC CDK7 G0SFC6_CHATD 6Z4XB G0SFC6 78 399 437.0 AGS:501 ATPlike Inactive DFGin 6.0664 15.963 None -120.32, -64.48 -72.18, 111.3 -111.88, 18.28 274.56, 83.55 -65.42, -11.7 in-out in 8.9011 Saltbr-out 3.7194 HRD-in -82.6, -50.25 63.05, 25.15 out-in-in SNCoii in-in ActLoopNT-in 2.7476 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.45, 163.36 APE9-dihe-na 70.87, 128.98 APE8-dihe-in -54.32, 144.95 APE8-rot-in 303.7 APE67-dihe-in -58.5, -22.2 -48.9, -49.43 APE12-dist-in 13.1214 APE11-dist-in 10.3276 APE10-dist-in 6.1584 APE9-dist-in 3.0434 None None None XRAY 2.98 0.205 0.246 B 437.0 322.0 0 28 28 0 [[92, 383]] 1.0 6z4x Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2.0 300.0 299.0 237 238 239 241 243 122 141 145 217 219 218 220.0 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
CMGC CDK7 G0SFC6_CHATD 6Z4XE G0SFC6 77 399 437.0 AGS:501 ATPlike Inactive DFGin 6.0452 15.8914 None -120.83, -65.38 -72.38, 111.16 -111.28, 19.39 275.38, 85.23 -65.84, -12.59 in-out in 8.9023 Saltbr-out 3.6666 HRD-in -79.74, -48.62 65.81, 23.05 out-in-in SNCoii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.65, 161.76 APE9-dihe-na 74.19, 130.39 APE8-dihe-in -54.74, 142.95 APE8-rot-in 302.5 APE67-dihe-in -58.43, -23.34 -50.65, -48.02 APE12-dist-in 13.252 APE11-dist-in 10.4227 APE10-dist-in 6.1469 APE9-dist-in 3.1587 None None None XRAY 2.98 0.205 0.246 E 437.0 323.0 0 28 28 0 [[92, 383]] 1.0 6z4x Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2.0 300.0 299.0 237 238 239 241 243 122 141 145 217 219 218 220.0 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5855 12.8524 None -92.38, -13.16 -130.85, 61.75 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.5425 APE10-dist-na 5.1047 APE9-dist-na 11.5716 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438.0 405.0 0 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6162 12.9181 None -91.62, -15.83 -130.65, 63.54 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.5804 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.1748 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.8933 APE11-dist-na 5.4782 APE10-dist-na 5.0793 APE9-dist-na 11.8701 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438.0 406.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.4924 12.6474 None -89.83, -13.71 -129.71, 95.5 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.5683 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.0361 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.8695 APE11-dist-na 5.4118 APE10-dist-na 5.1039 APE9-dist-na 11.7021 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438.0 397.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5811 12.83 None -92.56, -14.61 -129.54, 61.33 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.6323 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.9797 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.8492 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.6129 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438.0 407.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.7667 None -90.87, -14.73 -130.14, 65.48 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.9331 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.9622 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.8671 APE11-dist-na 5.5056 APE10-dist-na 4.9898 APE9-dist-na 11.6524 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438.0 394.0 10 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6574 12.9278 None -90.71, -14.62 -131.6, 64.5 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.6193 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.8968 APE11-dist-na 5.4715 APE10-dist-na 4.9808 APE9-dist-na 11.7452 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438.0 408.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.3451 12.7272 None -90.69, -14.9 -130.76, 66.96 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.6864 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.9562 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.8855 APE11-dist-na 5.4414 APE10-dist-na 4.9896 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438.0 397.0 11 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5482 12.9926 None -92.58, -12.35 -130.21, 41.87 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.5649 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.1131 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.8973 APE11-dist-na 5.5511 APE10-dist-na 5.0041 APE9-dist-na 11.6791 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438.0 407.0 7 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.6339 13.1429 None -107.98, -0.69 -128.2, 34.36 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.8242 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.7342 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.8957 APE11-dist-na 5.5654 APE10-dist-na 4.767 APE9-dist-na 12.0929 None None None XRAY 2.59 0.185 0.221 A 438.0 403.0 9 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6566 13.4069 None -109.51, -3.14 -128.47, 33.06 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.6072 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.7399 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.8265 APE11-dist-na 5.6867 APE10-dist-na 4.9609 APE9-dist-na 11.8917 None None None XRAY 2.59 0.185 0.221 B 438.0 412.0 10 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.6729 13.1643 None -108.29, -3.21 -129.06, 34.16 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.7221 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.9283 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.8857 APE11-dist-na 5.6634 APE10-dist-na 4.9314 APE9-dist-na 11.8945 None None None XRAY 2.59 0.185 0.221 C 438.0 404.0 8 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.7302 13.2458 None -109.91, -2.89 -127.7, 32.83 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.6595 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.8928 APE11-dist-na 5.6895 APE10-dist-na 4.875 APE9-dist-na 11.9374 None None None XRAY 2.59 0.185 0.221 D 438.0 411.0 11 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PKNG Q8NM29_CORGL 7MXBA Q8NM29 52 728 751.0 MAP:60901 Type1 Inactive DFGin 5.0742 11.2741 None -118.68, -14.76 -87.76, 64.62 -67.83, -34.44 189.61, 46.83 -64.01, -11.36 out-out out 16.9823 Saltbr-out 16.8857 HRD-in -83.43, -36.89 76.36, -45.68 out-in-in SNCoii in-in ActLoopNT-in 2.8687 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.58, 61.09 APE9-dihe-na -82.25, -173.13 APE8-dihe-in -124.32, 123.78 APE8-rot-in 301.48 APE67-dihe-inflip 105.13, -19.5 -60.8, 129.28 APE12-dist-in 10.9096 APE11-dist-in 8.2322 APE10-dist-in 5.3485 APE9-dist-in 4.1669 None None None XRAY 2.2 0.211 0.246 A 700.0 672.0 0 24 24 0 [[104, 300]] 1.0 7mxb Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 4.9e-20 78.5 1.0 186.0 186.0 246 247 248 250 252 134 151 155 227 229 228 230.0 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.3569 13.1741 None -145.49, -53.43 -88.36, 87.6 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.1764 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.1638 APE11-dist-in 13.9361 APE10-dist-out 17.3588 APE9-dist-out 9.4145 None None None XRAY 2.0 0.203 0.218 A 290.0 290.0 0 30 30 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.3e-138 465.4 1.0 265.0 265.0 224 225 226 228 230 106 120 124 199 201 200 202.0 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
OTHER PAN3 PAN3_DROME 4BWPA Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 8.9872 13.2943 None -64.87, -46.72 -145.48, 65.79 -71.61, -40.0 313.19, 999.0 -67.11, -37.22 out-na out 16.8319 Saltbr-na 999.0 HRD-in -50.58, -30.55 79.2, -55.76 na-out-na SNCaoa out-na ActLoopNT-out 6.6977 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -83.44, -6.17 APE9-dihe-na -63.0, 138.21 APE8-dihe-na -120.41, 140.18 APE8-rot-na 194.81 APE67-dihe-na -113.46, 118.54 -59.4, -45.27 APE12-dist-na 5.3059 APE11-dist-na 5.8273 APE10-dist-na 8.8341 APE9-dist-na 12.3414 None None None XRAY 3.6 0.222 0.269 A 448.0 386.0 23 18 18 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1.0 288.0 288.0 564 565 566 568 570 423 438 442 545 547 546 548.0 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_DROME 4BWPB Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 9.7361 13.9813 None -68.02, -47.7 -135.41, 45.28 -65.56, -36.8 296.47, 999.0 -63.81, -39.61 out-na out 16.5445 Saltbr-na 999.0 HRD-in -58.26, -35.46 80.55, -56.51 na-out-na SNCaoa out-na ActLoopNT-out 5.9619 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.2, -6.77 APE9-dihe-na -69.16, 143.64 APE8-dihe-na -96.5, 127.2 APE8-rot-na 212.33 APE67-dihe-na -115.77, 110.79 -63.6, -38.16 APE12-dist-na 4.419 APE11-dist-na 6.01 APE10-dist-na 8.8537 APE9-dist-na 11.2901 None None None XRAY 3.6 0.222 0.269 B 448.0 372.0 26 18 18 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1.0 288.0 288.0 564 565 566 568 570 423 438 442 545 547 546 548.0 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
TYR PTK2 FAK1_CHICK 4D4RA Q00944 414 685 1053.0 No_ligand No_ligand Inactive DFGin 6.7525 16.3152 None -128.64, 175.12 33.48, 60.17 -127.21, 999.0 60.14, 81.77 999.0, 999.0 in-out in 7.5542 Saltbr-out 4.2747 HRD-in -77.09, -46.72 78.72, -6.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.07 APE8-dihe-in -82.55, 72.75 APE8-rot-na 32.3 APE67-dihe-in -68.58, -11.96 -57.72, -42.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6768 None None None XRAY 1.55 0.202 0.221 A 276.0 251.0 21 29 11 18 [[422, 678]] 1.0 4d4r Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D4RB Q00944 412 684 1053.0 No_ligand No_ligand Inactive DFGin 7.0229 17.7358 None -78.09, 178.28 -54.92, 128.48 -75.07, -16.05 303.31, 165.11 -65.19, -11.08 out-out out 10.2314 Saltbr-out 10.1999 HRD-in -77.54, -48.96 77.86, -1.75 out-out-none SNCoon out-none ActLoopNT-out 10.0512 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.59 APE8-dihe-in -81.78, 61.99 APE8-rot-na 34.83 APE67-dihe-in -67.78, -12.73 -54.67, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7799 None None None XRAY 1.55 0.202 0.221 B 276.0 270.0 3 29 26 3 [[422, 678]] 1.0 4d4r Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D4SA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.3347 14.4902 None -114.18, -4.67 -150.83, 135.97 -129.43, 999.0 291.59, 99.53 999.0, 999.0 in-in in 7.8702 Saltbr-in 2.9877 HRD-in -76.62, -49.37 85.0, -10.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 143.71 APE9-dihe-in -71.69, 139.37 APE8-dihe-in -80.22, 72.42 APE8-rot-na 32.17 APE67-dihe-in -66.95, -17.13 -56.96, -41.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.103 None None None XRAY 2.0 0.207 0.225 A 276.0 255.0 17 29 12 17 [[422, 678]] 1.0 4d4s Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D4YA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.0184 14.5145 None -118.29, -10.26 -147.25, 131.73 -119.37, 999.0 297.41, 102.39 999.0, 999.0 in-in in 7.7981 Saltbr-in 2.4441 HRD-in -81.89, -51.68 81.97, -7.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -42.9 APE9-dihe-in -67.29, 140.52 APE8-dihe-in -79.28, 66.93 APE8-rot-na 16.31 APE67-dihe-in -68.8, -8.86 -56.17, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2511 None None None XRAY 1.8 0.189 0.227 A 276.0 255.0 17 29 12 17 [[422, 678]] 1.0 4d4y Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D58A Q00944 414 686 1053.0 No_ligand No_ligand Inactive DFGin 5.4479 14.9497 None -119.32, -6.79 -143.39, 120.13 -112.99, 999.0 292.94, 94.83 999.0, 999.0 in-in in 8.2041 Saltbr-in 2.7173 HRD-in -82.22, -48.88 82.65, -10.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.86 APE8-dihe-in -79.5, 65.59 APE8-rot-na 31.69 APE67-dihe-in -68.56, -13.14 -56.02, -40.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2547 None None None XRAY 1.95 0.197 0.228 A 276.0 255.0 18 29 11 18 [[422, 678]] 1.0 4d58 Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D5KA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.582 15.122 None -117.73, -5.95 -151.01, 133.04 -124.81, 999.0 284.01, 85.38 999.0, 999.0 in-in in 7.8884 Saltbr-in 3.5838 HRD-in -86.7, -47.97 80.45, -6.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -43.63 APE9-dihe-in -60.17, 136.23 APE8-dihe-in -79.08, 66.16 APE8-rot-na 27.0 APE67-dihe-in -72.5, -9.93 -52.21, -39.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2332 None None None XRAY 1.75 0.19 0.214 A 276.0 255.0 17 29 12 17 [[422, 678]] 1.0 4d5k Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY3A Q00944 35 686 1053.0 No_ligand No_ligand Inactive DFGin 6.5669 14.4517 None -135.16, 170.63 86.31, -91.36 58.85, 65.75 299.77, 89.22 -131.55, 157.07 in-out in 8.2587 Saltbr-out 3.768 HRD-in -98.85, -42.65 73.64, -10.05 out-out-out SNCooo out-out ActLoopNT-out 12.3607 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -84.38, 179.3 APE9-dihe-in -128.41, 160.02 APE8-dihe-in -77.79, 72.21 APE8-rot-na 27.16 APE67-dihe-in -64.5, -27.16 -60.23, -43.57 APE12-dist-na 14.9643 APE11-dist-na 15.5934 APE10-dist-na 17.373 APE9-dist-out 8.6292 None None None EM 6.32 999.0 999.0 A 658.0 600.0 10 29 19 10 [[422, 678]] 1.0 6ty3 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY3B Q00944 35 686 1053.0 No_ligand No_ligand Inactive DFGin 6.5666 14.4511 None -135.19, 170.62 86.26, -91.32 58.84, 65.75 299.77, 89.17 -131.52, 157.04 in-out in 8.2593 Saltbr-out 3.7672 HRD-in -98.85, -42.61 73.64, -10.1 out-out-out SNCooo out-out ActLoopNT-out 12.3602 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -84.36, 179.28 APE9-dihe-in -128.39, 160.01 APE8-dihe-in -77.75, 72.19 APE8-rot-na 27.19 APE67-dihe-in -64.56, -27.16 -60.28, -43.5 APE12-dist-na 14.9649 APE11-dist-na 15.5935 APE10-dist-na 17.3733 APE9-dist-out 8.6295 None None None EM 6.32 999.0 999.0 B 658.0 600.0 10 29 19 10 [[422, 678]] 1.0 6ty3 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2JKMA Q00944 413 686 1053.0 BII:1687 Type1 Inactive DFGin 6.9792 15.5966 None -114.99, -166.2 1.63, 119.82 87.35, -47.95 314.75, 124.67 -93.91, 178.82 in-in in 7.4247 Saltbr-in 2.8047 HRD-in -72.67, -52.48 88.19, -13.59 in-out-out SNCioo out-out ActLoopNT-out 14.999 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.01 APE8-dihe-in -71.46, 57.0 APE8-rot-na 27.37 APE67-dihe-in -75.95, 0.41 -40.68, -47.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1436 None None None XRAY 2.31 0.211 0.272 A 276.0 260.0 14 29 15 14 [[422, 678]] 1.0 2jkm Gallus gallus TYR_PTK2_CHICK TYR 1.4e-93 318.9 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2J0MB Q00944 414 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.9718 14.2866 None -122.76, 167.67 145.4, -137.08 -124.29, 100.35 290.36, 64.77 -132.69, 154.11 in-in in 7.4678 Saltbr-in 2.4434 HRD-in -71.25, -49.34 81.19, -3.46 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.23 APE8-dihe-in -85.72, 66.92 APE8-rot-na 31.09 APE67-dihe-in -64.84, -11.69 -52.92, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3786 None None None XRAY 2.8 0.224 0.282 B 276.0 257.0 16 29 13 16 [[422, 678]] 1.0 2j0m Gallus gallus TYR_PTK2_CHICK TYR 3.3e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2JKQA Q00944 414 686 1053.0 VG8:1687 Type1 Inactive DFGin 6.4335 15.7696 None -75.88, 179.74 -51.42, 124.37 -59.35, -36.75 304.41, 5.5 -52.05, -42.43 in-in in 7.4943 Saltbr-in 2.6234 HRD-in -66.06, -52.83 77.77, -12.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.31 APE8-dihe-in -81.47, 65.67 APE8-rot-na 31.77 APE67-dihe-in -69.2, -7.68 -48.0, -45.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8832 None None None XRAY 2.6 0.217 0.262 A 276.0 258.0 15 29 14 15 [[422, 678]] 1.0 2jkq Gallus gallus TYR_PTK2_CHICK TYR 3.3e-93 317.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2JKKA Q00944 413 684 1053.0 BI9:1686 Type1 Inactive DFGin 6.6615 15.9464 None -75.15, -171.72 -62.78, 135.39 -69.82, -36.92 292.96, 7.69 -58.64, -47.49 in-in in 7.4664 Saltbr-in 2.7948 HRD-in -67.23, -54.57 79.75, -14.16 in-out-none SNCion out-none ActLoopNT-out 10.5203 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.56 APE8-dihe-in -81.25, 65.87 APE8-rot-na 28.94 APE67-dihe-in -64.8, -17.36 -41.67, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9613 None None None XRAY 2.0 0.182 0.236 A 276.0 258.0 14 29 15 14 [[422, 678]] 1.0 2jkk Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2JKOA Q00944 415 686 1053.0 BIJ:1687 Type1 Inactive DFGin 6.8239 16.2882 None -76.65, 177.09 -51.97, 132.66 -73.02, -22.84 294.23, 6.85 -74.57, -42.86 in-in in 8.264 Saltbr-in 3.5763 HRD-in -81.96, -48.92 77.27, -4.29 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.22 APE8-dihe-in -78.31, 62.64 APE8-rot-na 29.54 APE67-dihe-in -67.04, -13.81 -48.71, -43.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9324 None None None XRAY 1.65 0.19 0.217 A 276.0 256.0 16 29 13 16 [[422, 678]] 1.0 2jko Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4BRXA Q00944 413 684 1053.0 KGW:1685 Type1 Inactive DFGin 6.5674 15.8037 None -85.04, -171.69 -52.6, 140.21 -75.53, -32.77 290.76, 3.08 -64.53, -44.35 in-in in 7.2763 Saltbr-in 2.8175 HRD-in -72.91, -56.18 75.54, -1.8 in-out-out SNCioo out-out ActLoopNT-out 10.4289 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.09 APE8-dihe-in -77.77, 68.02 APE8-rot-na 18.27 APE67-dihe-in -64.57, -19.31 -48.57, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2028 None None None XRAY 2.05 0.199 0.239 A 276.0 260.0 12 29 17 12 [[422, 678]] 1.0 4brx Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4C7TA Q00944 414 684 1053.0 5RI:1685 Type1 Inactive DFGin 6.5328 15.8402 None -77.4, -179.92 -52.87, 136.35 -71.95, -38.06 294.7, 1.19 -59.39, -44.61 in-in in 7.5173 Saltbr-in 2.969 HRD-in -72.59, -59.08 84.11, -4.81 in-out-none SNCion out-none ActLoopNT-out 10.4308 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.59 APE8-dihe-in -78.35, 70.91 APE8-rot-na 26.06 APE67-dihe-in -65.2, -16.6 -50.79, -47.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8934 None None None XRAY 2.05 0.22 0.246 A 276.0 259.0 12 29 17 12 [[422, 678]] 1.0 4c7t Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 4D5HA Q00944 415 686 1053.0 9RM:1687 Type1 Inactive DFGin 8.7894 16.1789 None -119.76, -8.44 -152.2, 131.56 -67.1, 999.0 180.84, 34.18 999.0, 999.0 in-out in 7.9099 Saltbr-out 3.7146 HRD-in -79.33, -48.38 80.51, -4.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.09 APE9-dihe-in -60.1, 142.63 APE8-dihe-in -82.47, 68.46 APE8-rot-na 31.45 APE67-dihe-in -67.73, -13.99 -56.02, -40.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1679 None None None XRAY 1.75 0.183 0.205 A 276.0 255.0 17 29 12 17 [[422, 678]] 1.0 4d5h Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6GCRA Q00944 413 684 1053.0 EUW:701 Type1 Inactive DFGin 6.7381 16.103 None -70.87, -166.97 -65.32, 125.1 -57.74, -34.57 287.47, 8.46 -73.02, -37.86 in-in in 7.5668 Saltbr-in 2.463 HRD-in -75.05, -55.09 81.04, -5.76 in-out-out SNCioo out-out ActLoopNT-out 10.4188 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.27 APE8-dihe-in -77.73, 61.32 APE8-rot-na 29.84 APE67-dihe-in -67.52, -6.96 -49.75, -48.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3585 None None None XRAY 2.3 0.214 0.262 A 276.0 258.0 14 29 15 14 [[422, 678]] 1.0 6gcr Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6GCWA Q00944 414 685 1053.0 EUQ:701 Type1 Inactive DFGin 6.2848 15.2282 None -130.25, -162.76 64.22, 75.01 -107.3, 999.0 290.51, 75.53 999.0, 999.0 in-out in 8.033 Saltbr-out 4.3767 HRD-in -81.64, -46.43 83.77, -4.99 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.84 APE8-dihe-in -78.48, 68.9 APE8-rot-na 34.42 APE67-dihe-in -73.52, -10.12 -55.06, -39.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3952 None None None XRAY 2.0 0.22 0.274 A 276.0 254.0 18 29 11 18 [[422, 678]] 1.0 6gcw Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6GCWB Q00944 414 686 1053.0 EUQ:701 Type1 Inactive DFGin 6.5394 15.8369 None -81.1, -172.36 -60.09, 131.66 -68.99, -32.35 293.15, 10.83 -65.72, -42.14 in-in in 7.5733 Saltbr-in 2.6791 HRD-in -76.57, -51.51 74.74, 1.93 in-out-out SNCioo out-out ActLoopNT-out 11.0698 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.67 APE8-dihe-in -80.93, 60.16 APE8-rot-na 31.79 APE67-dihe-in -70.89, -7.66 -53.84, -42.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8215 None None None XRAY 2.0 0.22 0.274 B 276.0 259.0 14 29 15 14 [[422, 678]] 1.0 6gcw Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6GCXA Q00944 413 686 1053.0 EUW:701 Type1 Inactive DFGin 6.7791 16.4446 None -72.0, 177.39 -57.13, 134.48 -70.38, -29.96 294.86, 177.92 -65.58, -46.38 in-in in 8.091 Saltbr-in 3.0472 HRD-in -82.56, -49.93 78.9, -6.95 in-out-out SNCioo out-out ActLoopNT-out 10.8456 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.29 APE8-dihe-in -79.72, 63.89 APE8-rot-na 33.8 APE67-dihe-in -69.74, -9.01 -53.44, -42.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0095 None None None XRAY 1.553 0.186 0.219 A 276.0 258.0 16 29 15 14 [[422, 678]] 1.0 6gcx Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2J0JA Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.9183 14.3851 None -123.19, 169.5 101.29, -103.63 66.49, 28.41 317.16, 97.31 -90.27, 177.52 in-in in 8.1193 Saltbr-in 2.703 HRD-in -78.32, -40.43 79.32, -8.22 in-out-out SNCioo out-out ActLoopNT-out 12.4634 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.84 APE8-dihe-in -80.69, 57.63 APE8-rot-na 26.07 APE67-dihe-in -61.42, -10.9 -40.75, -50.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8492 None None None XRAY 2.8 0.22 0.274 A 656.0 611.0 10 29 19 10 [[422, 678]] 1.0 2j0j Gallus gallus TYR_PTK2_CHICK TYR 3.1e-92 314.9 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2J0KA Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.8398 14.5218 None -94.55, -93.91 -78.14, -58.62 58.67, 36.74 310.17, 120.14 -115.82, 158.23 in-in in 8.1674 Saltbr-in 2.8344 HRD-in -98.8, -33.31 77.39, -21.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 52.29 APE9-dihe-in -82.72, 133.73 APE8-dihe-in -69.87, 64.39 APE8-rot-na 25.61 APE67-dihe-in -58.59, -19.95 -50.1, -51.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.019 APE9-dist-out 8.8097 None None None XRAY 3.0 0.237 0.299 A 656.0 598.0 15 29 14 15 [[422, 678]] 1.0 2j0k Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 2J0KB Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.7997 13.9437 None -96.91, -85.38 -80.15, -63.34 50.19, 5.1 328.51, 122.72 -57.61, 145.44 in-in in 8.0424 Saltbr-in 3.1137 HRD-in -78.83, -42.91 75.23, -10.09 in-out-out SNCioo out-out ActLoopNT-out 10.5128 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.8 APE8-dihe-in -80.14, 57.93 APE8-rot-na 30.91 APE67-dihe-in -67.94, -7.65 -42.39, -46.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.247 None None None XRAY 3.0 0.237 0.299 B 656.0 612.0 14 29 15 14 [[422, 678]] 1.0 2j0k Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR SRC SRC_CHICK 2QI8B P00523 258 533 533.0 No_ligand No_ligand Inactive DFGin 7.8612 16.8758 None -77.97, -158.42 -74.03, 88.42 -88.4, -16.79 67.11, 83.76 -79.48, -52.26 out-out out 13.8694 Saltbr-out 14.9403 HRD-in -91.82, -50.89 84.66, -18.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -12.95 APE8-rot-na 23.3 APE67-dihe-in -67.65, -27.2 -77.97, -14.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.32 0.209 0.28 B 286.0 249.0 27 29 13 16 [[267, 518]] 1.0 2qi8 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3OF0A P00523 257 533 533.0 No_ligand No_ligand Inactive DFGin 8.079 18.4892 None -146.9, -179.96 52.09, 63.41 -111.3, 49.26 188.56, 13.62 173.82, 999.0 in-none in 9.3325 Saltbr-none 999.0 HRD-in -91.09, -54.45 90.0, -20.95 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.7 APE8-dihe-out -72.72, 48.33 APE8-rot-na 342.06 APE67-dihe-in -71.97, -7.32 -51.77, -40.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.1476 L317I None None XRAY 2.7 0.235 0.262 A 286.0 260.0 17 29 12 17 [[267, 518]] 1.0 3of0 Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3OF0B P00523 257 533 533.0 No_ligand No_ligand Inactive DFGin 6.6309 17.2915 None -121.44, 158.78 55.92, 63.67 -66.14, -42.29 187.05, 74.23 -124.0, 999.0 out-none out 10.1078 Saltbr-none 999.0 HRD-in -83.6, -45.43 85.17, -21.22 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.75 APE8-dihe-in -77.48, 50.61 APE8-rot-na 348.02 APE67-dihe-in -69.18, -14.01 -51.46, -45.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3734 L317I None None XRAY 2.7 0.235 0.262 B 286.0 251.0 26 29 12 17 [[267, 518]] 1.0 3of0 Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3EN7B P00523 260 533 533.0 No_ligand No_ligand Inactive DFGin 7.013 14.9512 None -143.73, 172.49 60.52, 92.2 -105.14, 999.0 302.26, 91.11 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.81, -53.6 81.99, -18.76 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 22.06 APE8-rot-na 33.19 APE67-dihe-in -63.48, -28.45 -41.55, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.81 0.209 0.257 B 286.0 237.0 37 29 10 19 [[267, 518]] 1.0 3en7 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5D10B P00523 257 533 533.0 563:601 Type1 Inactive DFGin 7.4289 16.4733 None -133.04, -178.61 -87.44, -158.09 -136.33, 84.77 256.13, 100.97 150.07, -170.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.07, -45.84 84.08, -10.37 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.73 APE8-rot-na 24.74 APE67-dihe-in -54.59, -33.13 -71.82, -28.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.7 0.272 0.359 B 286.0 247.0 30 29 12 17 [[267, 518]] 1.0 5d10 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 6HVFA P00523 257 533 533.0 GUT:601 Type1 Inactive DFGin 7.457 16.4853 None -138.59, -176.51 57.27, 56.24 -78.59, 999.0 275.5, 89.04 999.0, 999.0 in-in in 8.1899 Saltbr-in 3.0031 HRD-in -83.09, -59.73 92.18, -12.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.35 APE8-rot-na 32.2 APE67-dihe-in -65.01, -20.46 -56.56, -37.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.1 0.212 0.245 A 286.0 246.0 31 29 10 19 [[267, 518]] 1.0 6hvf Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3QLFA P00523 258 533 533.0 PD5:601 Type1 Inactive DFGin 6.5921 16.183 None -149.92, 159.8 50.0, 78.08 -122.59, 999.0 79.02, 81.05 999.0, 999.0 in-none in 8.3977 Saltbr-none 999.0 HRD-in -102.3, -42.82 78.63, -40.47 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.26 APE8-dihe-in -83.56, 51.53 APE8-rot-na 4.24 APE67-dihe-in -63.39, -20.05 -50.25, -42.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2539 L317I None None XRAY 2.75 0.194 0.232 A 286.0 249.0 27 29 11 18 [[267, 518]] 1.0 3qlf Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3EN6B P00523 257 533 533.0 KS5:2 Type1 Inactive DFGin 6.6504 14.6384 None -130.32, 170.59 65.82, 71.11 -81.33, 999.0 291.91, 78.68 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.22, -54.73 87.09, -19.17 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -66.83, -19.55 999.0, -46.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.213 0.259 B 286.0 239.0 38 29 9 20 [[267, 518]] 1.0 3en6 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3EN7A P00523 256 533 533.0 ABJ:1 Type1 Inactive DFGin 6.7993 15.2664 None -131.18, 170.04 64.66, 73.9 -88.47, 999.0 287.94, 72.41 999.0, 999.0 out-none out 13.7848 Saltbr-none 999.0 HRD-in -82.22, -58.5 95.78, -28.27 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -21.12 APE8-rot-na 351.27 APE67-dihe-in -57.98, -25.97 -49.58, -41.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.81 0.209 0.257 A 286.0 247.0 31 29 10 19 [[267, 518]] 1.0 3en7 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4O2PA P00523 257 533 533.0 11V:601 Type1 Inactive DFGin 8.0578 17.1298 None -95.66, -160.19 -77.69, 78.89 -69.16, -32.26 54.5, 90.73 -73.56, -52.84 out-out out 10.7609 Saltbr-out 10.6081 HRD-in -76.83, -53.36 83.38, -20.14 out-out-out SNCooo out-out ActLoopNT-out 8.4513 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.81 APE8-dihe-in -95.12, 54.12 APE8-rot-na 25.28 APE67-dihe-in -61.76, -23.02 -71.35, -22.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6916 None None None XRAY 2.1 0.197 0.238 A 286.0 265.0 12 29 19 10 [[267, 518]] 1.0 4o2p Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 7AH3A P00523 257 533 533.0 RCK:601 Type1 Inactive DFGin 8.0994 17.1269 None -94.42, -158.53 -86.4, 76.82 -66.07, -31.23 51.59, 90.68 -69.81, -45.01 out-out out 12.2802 Saltbr-out 10.2659 HRD-in -75.61, -58.33 82.34, -9.46 out-out-none SNCoon out-none ActLoopNT-out 8.1168 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.1 APE8-rot-na 27.59 APE67-dihe-in -71.32, -13.88 -41.24, -37.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.189 0.226 A 286.0 265.0 12 29 17 12 [[267, 518]] 1.0 7ah3 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 8K79B P00523 269 533 533.0 IYC:601 Type1 Inactive DFGin 6.2753 13.6162 None -142.02, -165.55 59.65, 45.03 -69.39, 999.0 318.36, 96.34 999.0, 999.0 in-none in 8.2431 Saltbr-none 999.0 HRD-in -103.64, -40.14 66.81, -6.75 none-out-none SNCnon out-none ActLoopNT-out 5.8068 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.54 APE8-dihe-in -62.36, 104.78 APE8-rot-na 18.14 APE67-dihe-in -67.37, -19.95 -65.33, -31.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.1361 None None None XRAY 2.8 0.248 0.277 B 286.0 244.0 23 29 13 16 [[267, 518]] 1.0 8k79 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4LGGA P00523 264 533 533.0 VGG:601 Type1 Inactive DFGin 7.4586 16.3093 None -143.99, -175.58 60.26, 55.48 -85.7, 999.0 279.81, 89.82 999.0, 999.0 in-in in 8.2763 Saltbr-in 2.7967 HRD-in -80.21, -55.45 83.98, 3.12 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 90.19 APE8-rot-na 335.43 APE67-dihe-in -64.84, -21.94 -59.75, -40.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338G None None XRAY 2.41 0.238 0.285 A 270.0 241.0 29 29 10 19 [[267, 518]] 1.0 4lgg Gallus gallus TYR_SRC_CHICK TYR 2.3e-93 318.2 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4LGGB P00523 264 533 533.0 VGG:601 Type1 Inactive DFGin 7.2053 15.9784 None -143.86, -173.8 55.54, 66.67 -91.46, 999.0 283.89, 82.38 999.0, 999.0 in-in in 8.3266 Saltbr-in 2.7174 HRD-in -83.08, -59.41 91.8, -22.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.8 APE8-rot-na 28.86 APE67-dihe-in -67.2, -17.89 -63.93, -34.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338G None None XRAY 2.41 0.238 0.285 B 270.0 245.0 25 29 10 19 [[267, 518]] 1.0 4lgg Gallus gallus TYR_SRC_CHICK TYR 2.3e-93 318.2 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2HWOB P00523 258 533 533.0 RBS:1345 Type1 Inactive DFGin 7.4463 16.7569 None -142.66, 177.84 48.56, 63.89 -65.19, 999.0 276.69, 83.46 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -98.03, -53.6 90.58, -24.9 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 52.78 APE8-rot-na 32.73 APE67-dihe-in -63.88, -24.33 -65.14, -25.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S345C None None XRAY 2.5 0.238 0.292 B 286.0 242.0 34 29 10 19 [[267, 518]] 1.0 2hwo Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2HWPA P00523 256 533 533.0 DJK:1345 Type1 Inactive DFGin 4.9448 11.4913 None -149.7, 174.68 63.8, 24.74 24.42, 999.0 327.73, 96.53 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -76.7, -56.82 88.65, -21.99 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.02 APE8-dihe-in -78.72, 120.33 APE8-rot-na 32.38 APE67-dihe-in -69.35, -32.46 -64.49, -21.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.5907 S345C None None XRAY 2.48 0.228 0.276 A 286.0 245.0 33 29 11 18 [[267, 518]] 1.0 2hwp Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4LGHA P00523 257 533 533.0 0JN:601 Type1 Inactive DFGin 6.9841 15.7897 None -153.73, -177.11 55.11, 69.07 -80.53, 999.0 289.05, 74.19 999.0, 999.0 in-out in 9.2031 Saltbr-out 10.922 HRD-out -100.29, 92.72 -56.91, -30.62 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 23.24 APE8-rot-na 31.99 APE67-dihe-in -69.83, -39.6 -61.27, -32.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338G None None XRAY 2.84 0.216 0.272 A 277.0 243.0 34 29 10 19 [[267, 518]] 1.0 4lgh Gallus gallus TYR_SRC_CHICK TYR 2.5e-93 318.0 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4LGHB P00523 259 533 533.0 0JN:601 Type1 Inactive DFGin 8.4608 17.0147 None -87.06, -150.22 -90.59, 77.55 -61.39, -5.78 49.04, 92.12 -122.47, 93.03 out-none out 12.5152 Saltbr-none 999.0 HRD-out -92.47, 101.6 -76.08, -4.72 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 4.95 APE8-rot-na 33.13 APE67-dihe-in -61.02, -21.67 -62.96, -38.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338G None None XRAY 2.84 0.216 0.272 B 277.0 247.0 28 29 12 17 [[267, 518]] 1.0 4lgh Gallus gallus TYR_SRC_CHICK TYR 2.5e-93 318.0 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4MCVB P00523 257 533 533.0 29K:601 Type1 Inactive DFGin 6.5779 14.5177 None -111.05, -91.71 -54.53, 101.39 -99.75, 24.59 297.04, 135.4 -66.22, -20.64 in-none in 8.6792 Saltbr-none 999.0 HRD-out -91.75, 94.41 -63.21, -28.33 none-in-out SNCnio in-out ActLoopNT-in 3.3836 ActLoopCT-out TYR APEdihe_noiai APEdist_aaao APE10-dihe-none 999.0, -64.72 APE9-dihe-out -78.76, -45.22 APE8-dihe-in -67.37, 93.43 APE8-rot-na 21.86 APE67-dihe-in -62.54, -30.51 -60.98, -34.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.2773 APE9-dist-out 8.2307 T338G None None XRAY 2.73 0.243 0.29 B 278.0 265.0 12 29 18 11 [[267, 518]] 1.0 4mcv Gallus gallus TYR_SRC_CHICK TYR 2.6e-93 318.0 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5T0PA P00523 257 533 533.0 73A:600 Type1 Inactive DFGin 4.3573 13.0469 None -108.06, -94.22 -78.77, 78.46 -95.95, 36.88 46.97, 79.53 -69.4, 116.82 in-out in 7.9811 Saltbr-out 4.0612 HRD-in -76.47, -49.02 77.78, -0.46 out-in-none SNCoin in-none ActLoopNT-in 3.0342 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.81 APE8-rot-na 33.7 APE67-dihe-in -60.65, -32.77 -54.16, -43.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V313C None None XRAY 2.5 0.267 0.323 A 286.0 264.0 13 29 16 13 [[267, 518]] 1.0 5t0p Gallus gallus TYR_SRC_CHICK TYR 4.9e-94 320.4 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5T0PB P00523 258 533 533.0 73A:600 Type1 Inactive DFGin 6.0347 13.9864 None -105.32, -89.98 -65.65, 94.02 -87.72, 23.24 309.83, 102.99 -75.54, -3.08 in-out in 7.89 Saltbr-out 4.0724 HRD-in -75.88, -49.59 76.61, 0.68 out-in-none SNCoin in-none ActLoopNT-in 3.0052 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 20.14 APE8-rot-na 33.29 APE67-dihe-in -60.74, -32.25 -53.16, -44.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V313C None None XRAY 2.5 0.267 0.323 B 286.0 263.0 13 29 16 13 [[267, 518]] 1.0 5t0p Gallus gallus TYR_SRC_CHICK TYR 4.9e-94 320.4 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2QLQA P00523 256 533 533.0 SR2:1345,SR2:1483 Type1,Allosteric Inactive DFGin 6.9884 15.8146 None -132.63, -179.88 43.58, 57.27 -47.86, 999.0 281.23, 68.03 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -89.12, -52.37 88.94, -22.71 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 101.84 APE8-rot-na 326.98 APE67-dihe-in -62.91, -20.52 -104.71, 0.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S345C None None XRAY 2.33 0.215 0.267 A 286.0 245.0 33 29 10 19 [[267, 518]] 1.0 2qlq Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5TEHA P00523 256 533 533.0 S56:600 Type1.5_Back Inactive DFGin 5.9639 13.5045 None -165.57, -155.39 40.26, 84.58 -84.9, -72.66 314.29, 99.49 -61.22, 999.0 out-out out 10.6204 Saltbr-out 5.2868 HRD-in -98.4, -39.03 82.49, -52.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.47 APE8-dihe-in -96.16, 52.27 APE8-rot-na 35.96 APE67-dihe-in -76.12, -20.57 -66.98, -13.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5237 V281C None None XRAY 2.99 0.307 0.366 A 286.0 261.0 17 29 12 17 [[267, 518]] 1.0 5teh Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3QLFB P00523 258 533 533.0 PD5:601 Type1.5_Front Inactive DFGin 6.1412 12.6014 None -150.33, 164.09 75.91, 111.22 -150.95, 999.0 2.54, 56.9 999.0, 999.0 out-none out 11.1152 Saltbr-none 999.0 HRD-in -102.4, -44.0 81.56, -46.14 none-in-out SNCnio in-out ActLoopNT-in 3.2215 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -83.83, 51.78 APE8-rot-na 4.43 APE67-dihe-in -63.43, -19.12 -50.83, -42.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2932 L317I None None XRAY 2.75 0.194 0.232 B 286.0 258.0 18 29 13 16 [[267, 518]] 1.0 3qlf Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TKL LYR4 G7K7K0_MEDTR 8PS7A G7K7K0 340 636 660.0 ANP:704 ATPlike Pseudo DFGin 7.3438 12.4911 None -132.7, -71.23 -80.99, 65.77 -101.31, -4.53 43.9, 75.68 -166.17, 141.69 out-out out 12.6635 Saltbr-out 13.161 HRD-in -67.54, -63.16 83.85, -10.66 out-out-out SNCooo out-out ActLoopNT-out 9.632 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.12, -49.62 APE9-dihe-na -62.67, -34.57 APE8-dihe-out -58.19, -50.78 APE8-rot-in 276.77 APE67-dihe-in -82.12, -28.85 -67.98, -32.83 APE12-dist-out 14.2466 APE11-dist-out 19.2311 APE10-dist-out 20.4004 APE9-dist-out 9.2958 None None None XRAY 2.1 0.225 0.269 A 297.0 279.0 18 33 33 0 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13.0 266.0 254.0 493 494 495 497 499 379 388 392 473 475 474 476.0 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
OTHER BUD32 KAE1B_METJA 2VWBA Q58530 1 530 535.0 ANP:1531 Allosteric Inactive DFGin 6.8437 17.1317 None -120.64, -3.56 -136.03, 137.71 -148.58, 37.82 232.34, 113.93 -66.32, -14.47 in-in in 7.9752 Saltbr-in 2.7284 HRD-out -83.04, 140.14 -107.29, 16.57 in-in-na SNCiia in-na ActLoopNT-in 2.9164 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.96, -33.04 APE9-dihe-na -68.59, -42.86 APE8-dihe-na -73.15, -19.01 APE8-rot-na 294.55 APE67-dihe-na -59.99, -36.61 -63.88, -52.94 APE12-dist-na 17.0179 APE11-dist-na 12.319 APE10-dist-na 14.9692 APE9-dist-na 11.6624 None None None XRAY 3.05 0.224 0.301 A 535.0 519.0 4 23 23 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 2VWBB Q58530 1 532 535.0 ANP:1533 Allosteric Inactive DFGin 6.5797 16.7156 None -128.01, -5.24 -139.71, 160.08 -157.9, 25.33 238.13, 113.59 -41.68, -37.13 in-in in 7.8464 Saltbr-in 3.1753 HRD-out -90.81, 128.03 -91.65, 20.67 in-in-na SNCiia in-na ActLoopNT-in 2.657 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -74.1, -29.36 APE9-dihe-na -76.07, -42.12 APE8-dihe-na -69.9, -15.57 APE8-rot-na 312.74 APE67-dihe-na -42.13, -37.17 -74.66, -63.72 APE12-dist-na 16.6492 APE11-dist-na 12.1119 APE10-dist-na 14.818 APE9-dist-na 11.4755 None None None XRAY 3.05 0.224 0.301 B 535.0 507.0 8 23 23 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 3EN9A Q58530 1 534 535.0 TBR:60601 Allosteric Inactive DFGin 6.6582 16.7462 None -134.44, -0.31 -125.15, 143.48 -154.72, 21.38 233.8, 116.65 -62.18, -16.93 in-in in 7.873 Saltbr-in 2.968 HRD-out -101.58, 104.27 -87.64, 28.76 in-in-na SNCiia in-na ActLoopNT-in 2.6862 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -71.3, -40.31 APE9-dihe-na -58.09, -54.55 APE8-dihe-na -54.72, -36.92 APE8-rot-na 170.93 APE67-dihe-na -64.68, -33.79 -56.83, -50.19 APE12-dist-na 16.5461 APE11-dist-na 11.9879 APE10-dist-na 14.7021 APE9-dist-na 11.8501 None None None XRAY 2.67 0.205 0.264 A 540.0 516.0 9 23 23 0 [[334, 534]] 1.0 3en9 Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.7e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 3EN9B Q58530 1 529 535.0 TBR:60601 Allosteric Inactive DFGin 6.7645 17.0062 None -132.67, 10.26 -148.47, 138.5 -157.5, 29.4 228.09, 116.97 -68.96, -12.89 in-in in 7.9834 Saltbr-in 2.8967 HRD-in -94.77, -42.03 67.36, 13.43 in-in-na SNCiia in-na ActLoopNT-in 2.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.33, -30.37 APE9-dihe-na -63.66, -55.11 APE8-dihe-na -49.33, -47.59 APE8-rot-na 211.79 APE67-dihe-na -76.88, -29.96 -52.7, -40.55 APE12-dist-na 17.2074 APE11-dist-na 12.093 APE10-dist-na 14.5147 APE9-dist-na 11.8468 None None None XRAY 2.67 0.205 0.264 B 540.0 509.0 13 23 23 0 [[334, 534]] 1.0 3en9 Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.7e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 3ENHA Q58530 1 534 535.0 TBR:64769,TBR:65769,TBR:66769 Allosteric,Allosteric,Allosteric Inactive DFGin 6.6093 16.9341 None -95.41, 19.07 -156.54, 140.87 -153.31, 3.02 223.74, 105.19 -20.11, -54.37 in-in in 7.2465 Saltbr-in 2.7218 HRD-out -61.32, 155.11 -124.33, 4.45 in-in-na SNCiia in-na ActLoopNT-in 3.3996 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -51.49, -45.67 APE9-dihe-na -64.17, -38.92 APE8-dihe-na -63.93, -42.61 APE8-rot-na 164.75 APE67-dihe-na -60.92, -57.53 -63.62, -34.7 APE12-dist-na 17.7176 APE11-dist-na 13.0064 APE10-dist-na 15.5998 APE9-dist-na 11.6009 None None None XRAY 3.6 0.274 0.324 A 540.0 495.0 10 23 23 0 [[334, 534]] 1.0 3enh Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.7e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 3ENHB Q58530 1 529 535.0 TBR:62769,TBR:63769,TBR:67769,TBR:68769 Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 6.6197 16.9299 None -94.55, 18.23 -156.56, 140.99 -152.1, 2.98 223.24, 106.74 -21.74, -55.89 in-in in 7.2512 Saltbr-in 2.6963 HRD-out -61.26, 154.71 -123.06, 3.16 in-in-na SNCiia in-na ActLoopNT-in 3.4035 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -51.47, -46.52 APE9-dihe-na -63.92, -38.68 APE8-dihe-na -63.4, -43.04 APE8-rot-na 165.31 APE67-dihe-na -61.32, -57.53 -64.45, -33.8 APE12-dist-na 17.7249 APE11-dist-na 13.0114 APE10-dist-na 15.6248 APE9-dist-na 11.5901 None None None XRAY 3.6 0.274 0.324 B 540.0 485.0 19 23 19 4 [[334, 534]] 1.0 3enh Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.7e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 8UP5B Q58530 345 533 535.0 No_ligand No_ligand Inactive DFGin 7.3138 17.598 None -82.56, 2.91 -148.25, 146.71 -140.26, 27.42 205.97, 89.37 -57.74, -46.99 in-in in 8.4899 Saltbr-in 2.4911 HRD-out -121.34, 101.07 -89.7, 27.11 in-in-na SNCiia in-na ActLoopNT-in 2.8807 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -62.4, -41.79 APE9-dihe-na -62.96, -43.23 APE8-dihe-na -66.74, -35.25 APE8-rot-na 56.7 APE67-dihe-na -60.7, -38.56 -62.84, -43.15 APE12-dist-na 16.8357 APE11-dist-na 11.841 APE10-dist-na 14.1937 APE9-dist-na 11.6432 E478R None None EM 3.56 999.0 999.0 B 203.0 189.0 12 23 23 0 [[334, 534]] 1.0 8up5 Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 9.4e-45 159.6 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
AGC PRKACA KAPCA_MOUSE 4NTTA P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.2546 15.2208 None 58.0, -132.96 -135.23, 163.83 -122.73, 17.77 281.43, 74.72 -41.46, -50.2 in-out in 9.9815 Saltbr-out 4.1938 HRD-in -65.11, -40.77 60.9, 3.38 out-in-in SNCoii in-in ActLoopNT-in 2.8637 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 118.31 APE9-dihe-na 164.12, -173.28 APE8-dihe-in -108.19, 123.7 APE8-rot-in 267.93 APE67-dihe-in -75.4, -22.82 -40.35, -37.34 APE12-dist-in 8.1876 APE11-dist-in 11.1589 APE10-dist-in 5.5421 APE9-dist-in 4.3211 None TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 A 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1SYKA P05132 2 351 351.0 No_ligand No_ligand Inactive DFGin 6.5487 15.2891 None -131.76, 92.58 153.52, 114.28 -135.97, 14.86 305.19, 86.4 -55.43, -35.39 out-out out 10.6501 Saltbr-out 4.6701 HRD-out -89.49, 87.61 -76.68, 28.19 out-in-in SNCoii in-in ActLoopNT-in 2.8271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.89, 158.84 APE9-dihe-na 108.08, 161.46 APE8-dihe-in -68.78, 138.01 APE8-rot-in 292.07 APE67-dihe-in -58.35, -9.3 -44.71, -57.38 APE12-dist-in 8.6724 APE11-dist-in 11.389 APE10-dist-in 5.9774 APE9-dist-in 3.618 E231Q TPO198,SEP339 TPO198,SEP339 XRAY 2.8 0.202 0.249 A 350.0 350.0 0 25 25 0 [[44, 298]] 1.0 1syk Mus musculus AGC_PRKACA_MOUSE AGC 5.7e-94 320.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1SYKB P05132 14 351 351.0 No_ligand No_ligand Inactive DFGin 6.599 15.2944 None -131.1, 91.72 152.06, 111.8 -131.83, 14.93 304.13, 82.92 -52.5, -38.6 out-out out 10.6973 Saltbr-out 4.5374 HRD-out -89.8, 89.72 -78.69, 28.99 out-in-in SNCoii in-in ActLoopNT-in 2.7813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.75, 160.3 APE9-dihe-na 107.8, 162.07 APE8-dihe-in -68.75, 135.04 APE8-rot-in 292.48 APE67-dihe-in -58.91, -9.06 -42.82, -56.64 APE12-dist-in 8.6623 APE11-dist-in 11.3639 APE10-dist-in 5.9602 APE9-dist-in 3.6147 E231Q TPO198,SEP339 TPO198,SEP339 XRAY 2.8 0.202 0.249 B 350.0 325.0 0 25 25 0 [[44, 298]] 1.0 1syk Mus musculus AGC_PRKACA_MOUSE AGC 5.7e-94 320.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A P18654 47 346 740.0 ANP:480 ATPlike Inactive DFGin 5.9199 11.0415 None -85.91, -4.29 -148.29, 179.42 -140.68, 33.76 40.5, 80.74 98.88, 16.23 none-none none 999.0 Saltbr-none 999.0 HRD-in -65.38, -43.56 85.71, -58.97 none-out-none SNCnon out-none ActLoopNT-out 10.0751 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.27 APE8-rot-in 334.43 APE67-dihe-in -57.95, -24.46 -80.48, -16.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.216 0.248 A 325.0 280.0 20 28 17 11 [[68, 327], [422, 679]] 2.0 3g51 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.6e-97 330.9 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
CAMK AURKA AURKA_MOUSE 3DJ5A P97477 119 379 395.0 AK5:60001 Type1.5_Front Inactive DFGin 7.6284 14.0475 None -136.29, 19.35 -86.03, 63.82 -110.83, -25.4 302.03, 108.73 -69.83, 159.06 out-out out 12.978 Saltbr-out 9.961 HRD-out -131.01, 157.62 -122.24, -24.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.12, -1.39 APE9-dihe-na 118.23, -161.25 APE8-dihe-in -83.03, 126.77 APE8-rot-in 300.87 APE67-dihe-in -53.36, -22.0 -45.96, -54.49 APE12-dist-out 14.9045 APE11-dist-out 15.549 APE10-dist-out 15.4089 APE9-dist-out 17.2512 N164G,K218R,M280L None None XRAY 1.8 0.21 0.243 A 272.0 252.0 9 26 17 9 [[124, 374]] 1.0 3dj5 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3DJ6A P97477 119 379 395.0 AK6:60001 Type1.5_Front Inactive DFGin 7.5112 14.321 None -137.4, 19.75 -87.35, 63.1 -109.74, -19.59 301.75, 109.1 -74.07, 159.87 out-out out 12.9421 Saltbr-out 9.941 HRD-out -131.2, 158.79 -119.8, -29.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -104.43, 1.85 APE9-dihe-na 118.27, -159.99 APE8-dihe-in -81.23, 128.14 APE8-rot-in 303.03 APE67-dihe-in -53.67, -23.26 -47.45, -53.56 APE12-dist-out 15.1307 APE11-dist-out 15.7144 APE10-dist-out 15.886 APE9-dist-out 17.3598 N164G,K218R,M280L None None XRAY 1.7 0.217 0.261 A 272.0 252.0 9 26 17 9 [[124, 374]] 1.0 3dj6 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK RPS6KA3-2 KS6A3_MOUSE 4MAOA P18654 415 712 740.0 28D:801 Type1 Inactive DFGin 6.9498 13.9692 None -122.16, -3.09 -110.62, -87.21 89.06, 8.42 296.98, 89.53 -66.42, 0.71 in-in in 8.7172 Saltbr-in 3.0464 HRD-in -80.58, -55.21 74.16, -0.39 in-in-out SNCiio in-out ActLoopNT-in 2.9492 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -78.96, -40.3 APE9-dihe-na -99.2, 112.48 APE8-dihe-out -111.75, -5.25 APE8-rot-out 40.44 APE67-dihe-out -98.05, 166.61 -67.15, -3.4 APE12-dist-out 18.9517 APE11-dist-out 18.4684 APE10-dist-out 22.8607 APE9-dist-out 24.2627 T493M,K591E None None XRAY 2.6 0.238 0.292 A 355.0 298.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4mao Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 1.1e-87 299.7 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
CMGC MAPK14 MK14_MOUSE 6SOUA P47811 5 352 360.0 LPZ:406,LPZ:407 Allosteric,Type1 Inactive DFGin 7.3625 16.8084 None -133.04, -176.46 59.36, 52.66 -52.08, 999.0 288.27, 77.53 999.0, 999.0 in-in in 9.7302 Saltbr-in 2.8273 HRD-in -72.19, -51.58 83.69, -12.25 in-out-out SNCioo out-out ActLoopNT-out 12.0028 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.59, 133.82 APE9-dihe-na -63.41, -18.88 APE8-dihe-out -63.42, -15.13 APE8-rot-out 53.27 APE67-dihe-in -66.48, -19.16 -115.28, -17.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8872 None None None XRAY 1.5 0.216 0.233 A 381.0 342.0 6 25 22 3 [[24, 308]] 1.0 6sou Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3TG1A P47811 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.8247 16.0345 None -116.32, 155.59 -1.61, 110.61 -70.76, 999.0 331.08, 173.37 999.0, 999.0 in-in in 9.7774 Saltbr-in 3.192 HRD-in -71.22, -51.39 75.49, -16.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.05 APE8-dihe-out -54.64, -33.8 APE8-rot-out 159.97 APE67-dihe-in -72.3, -17.1 -60.98, -22.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2156 None None None XRAY 2.71 0.311 0.26 A 380.0 334.0 14 25 11 14 [[24, 308]] 1.0 3tg1 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 2GHMA P47811 5 352 360.0 LIC:353 Type1 Inactive DFGin 5.7845 13.7767 None -78.81, 171.19 -55.87, 93.41 -25.52, 88.72 34.83, 93.47 -170.14, 167.5 in-in in 9.288 Saltbr-in 3.2035 HRD-in -62.78, -61.35 90.75, -25.48 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -53.87 APE9-dihe-na -71.96, -67.71 APE8-dihe-out -49.26, -48.1 APE8-rot-in 270.21 APE67-dihe-in -62.91, -14.17 -44.49, -46.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.3212 APE9-dist-out 11.3867 T180A,Y182F None None XRAY 2.35 0.232 0.323 A 348.0 336.0 12 25 14 11 [[24, 308]] 1.0 2ghm Mus musculus CMGC_MAPK14_MOUSE CMGC 6.3e-84 287.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 1YW2A P47811 4 353 360.0 PGJ:62001 Type1 Inactive DFGin 7.4408 13.8889 None -108.87, 130.98 -78.03, -31.11 -137.46, 121.59 317.27, 85.69 -153.54, 999.0 in-in in 9.1653 Saltbr-in 2.8889 HRD-in -65.03, -58.53 71.57, -11.34 in-out-out SNCioo out-out ActLoopNT-out 19.2412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 140.08 APE9-dihe-na -171.64, 79.36 APE8-dihe-out -4.97, -52.19 APE8-rot-out 22.63 APE67-dihe-in -78.16, -22.44 -73.05, -7.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3444 T180A,Y182F None None XRAY 2.01 0.207 0.29 A 360.0 341.0 9 25 16 9 [[24, 308]] 1.0 1yw2 Mus musculus CMGC_MAPK14_MOUSE CMGC 7.1e-84 287.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 2GTMA P47811 5 352 360.0 LID:353 Type1 Inactive DFGin 10.5798 12.2976 None -99.42, 151.2 -66.85, -46.24 -140.98, 139.16 303.6, 104.59 -99.33, -162.53 in-in in 9.0195 Saltbr-in 2.6326 HRD-in -70.94, -57.65 84.88, -6.9 in-out-out SNCioo out-out ActLoopNT-out 21.3254 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -146.35, 106.63 APE9-dihe-na -84.71, 129.28 APE8-dihe-out -45.44, -51.38 APE8-rot-in 285.81 APE67-dihe-in -54.42, -30.85 -58.09, -32.0 APE12-dist-none 999.0 APE11-dist-in 10.9379 APE10-dist-out 9.1615 APE9-dist-out 10.8018 None None None XRAY 1.9 0.231 0.261 A 348.0 341.0 7 25 21 4 [[24, 308]] 1.0 2gtm Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 2GTNA P47811 5 352 360.0 LIE:354 Type1 Inactive DFGin 10.5589 12.1049 None -97.49, 148.4 -66.36, -50.18 -132.83, 140.82 310.6, 94.93 -102.32, -165.42 in-in in 8.8869 Saltbr-in 2.5937 HRD-in -68.82, -53.97 78.95, -12.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.88 APE8-dihe-out -46.6, -50.56 APE8-rot-in 275.26 APE67-dihe-in -60.86, -30.99 -59.17, -25.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8082 None None None XRAY 1.8 0.203 0.248 A 348.0 337.0 11 25 14 11 [[24, 308]] 1.0 2gtn Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8ACOAAA P47811 4 352 360.0 SB2:401 Type1 Inactive DFGin 5.7374 14.0092 None -148.97, 178.49 24.89, 96.95 -83.03, 999.0 316.51, 111.13 999.0, 999.0 in-in in 9.3324 Saltbr-in 2.582 HRD-in -68.93, -56.93 87.8, -49.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -122.76 APE8-rot-in 323.22 APE67-dihe-in -64.13, -36.89 -112.86, 8.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.212 0.278 AAA 359.0 334.0 15 25 10 15 [[24, 308]] 1.0 8aco Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9UA P47811 5 352 360.0 JMM:401 Type1 Inactive DFGin 7.8704 16.4146 None -105.42, 167.68 86.02, 81.87 -120.77, 999.0 293.85, 91.32 999.0, 999.0 in-in in 9.5521 Saltbr-in 2.9149 HRD-in -68.92, -55.3 81.59, -7.51 in-out-out SNCioo out-out ActLoopNT-out 10.0022 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -133.83, 134.83 APE9-dihe-na -63.75, -21.85 APE8-dihe-out -58.31, -17.35 APE8-rot-out 54.12 APE67-dihe-in -65.05, -20.74 -118.93, -19.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6787 None None None XRAY 1.67 0.187 0.213 A 360.0 345.0 3 25 22 3 [[24, 308]] 1.0 5r9u Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8EFJA P47811 5 360 360.0 WHQ:503 Type1 Inactive DFGin 6.6842 15.1508 None -107.83, -138.53 -47.2, 131.52 -82.89, 153.62 283.8, 59.38 -72.43, 123.55 in-in in 9.147 Saltbr-in 2.8713 HRD-in -63.56, -52.6 86.58, -8.43 in-out-out SNCioo out-out ActLoopNT-out 9.1047 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -48.45 APE9-dihe-na -142.16, 106.07 APE8-dihe-in -57.79, 138.19 APE8-rot-out 182.41 APE67-dihe-in -58.85, -41.56 -95.36, -2.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.8627 APE9-dist-out 9.537 None None None XRAY 2.31 0.193 0.223 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8efj Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8VMHA P47811 5 354 360.0 A1ACT:603 Type1 Inactive DFGin 10.8876 12.6554 None -91.57, 155.22 -78.87, -42.97 -134.13, 132.21 306.13, 106.97 -93.28, -173.32 in-in in 9.1199 Saltbr-in 2.4999 HRD-in -70.23, -50.72 73.72, -8.99 in-out-out SNCioo out-out ActLoopNT-out 21.4911 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 65.99 APE9-dihe-na -65.29, 141.53 APE8-dihe-out -65.65, -35.56 APE8-rot-in 296.74 APE67-dihe-in -54.93, -23.21 -63.02, -29.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.7755 APE9-dist-out 11.8061 None None None XRAY 2.46 0.21 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmh Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8VMMA P47811 5 354 360.0 A1ACP:602 Type1 Inactive DFGin 10.9836 13.1585 None -98.06, 143.62 -67.61, -42.07 -138.88, 122.62 295.3, 103.53 -85.47, 178.15 in-in in 9.4266 Saltbr-in 2.5383 HRD-in -74.94, -56.81 76.36, -7.57 in-out-out SNCioo out-out ActLoopNT-out 21.1108 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.41 APE9-dihe-na -75.99, -11.35 APE8-dihe-out 77.98, -40.95 APE8-rot-in 311.13 APE67-dihe-in -68.54, -15.53 -53.31, -26.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5031 APE9-dist-out 11.8253 None None None XRAY 2.4 0.207 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8VT6A P47811 5 360 360.0 WHQ:503 Type1 Inactive DFGin 6.7293 15.1507 None -106.7, -137.28 -49.07, 131.85 -82.77, 153.72 284.07, 57.8 -72.41, 123.53 in-in in 9.1741 Saltbr-in 2.5587 HRD-in -64.24, -49.87 82.02, -7.33 in-out-out SNCioo out-out ActLoopNT-out 9.1157 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -58.08 APE9-dihe-na -131.51, 108.06 APE8-dihe-in -61.02, 149.49 APE8-rot-out 183.06 APE67-dihe-in -60.32, -29.4 -95.05, -11.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.7558 APE9-dist-out 9.4982 None None None XRAY 2.31 0.166 0.216 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8vt6 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 8VWMA P47811 5 360 360.0 WHE:401 Type1 Inactive DFGin 6.7659 15.2325 None -105.37, -136.33 -48.31, 132.67 -83.1, 152.37 281.96, 61.27 -72.7, 123.36 in-in in 9.177 Saltbr-in 2.8721 HRD-in -65.49, -53.48 85.5, -8.91 in-out-out SNCioo out-out ActLoopNT-out 9.1811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -44.6 APE9-dihe-na -141.61, 100.51 APE8-dihe-in -61.36, 142.62 APE8-rot-out 185.47 APE67-dihe-in -63.84, -26.29 -92.21, -4.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.0139 APE9-dist-out 9.637 None None None XRAY 1.94 0.177 0.222 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8vwm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 2EWAA P47811 5 354 360.0 SB2:361 Type1 Inactive DFGin 6.575 15.1465 None -155.19, 179.59 -144.72, 110.73 -99.77, 145.73 66.01, 43.3 59.16, 999.0 in-in in 9.4738 Saltbr-in 2.6977 HRD-in -67.14, -51.92 76.56, -18.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -36.62 APE8-rot-in 319.01 APE67-dihe-in -54.41, -29.01 -77.11, -17.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.241 0.279 A 379.0 330.0 20 25 11 14 [[24, 308]] 1.0 2ewa Mus musculus CMGC_MAPK14_MOUSE CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 6YCUA P47811 6 359 360.0 SB4:401,OKZ:405 Type1,Allosteric Inactive DFGin 6.0979 14.3679 None -143.57, 175.48 60.18, 42.46 -110.51, 999.0 50.6, 83.02 999.0, 999.0 in-in in 9.1165 Saltbr-in 2.6532 HRD-in -71.9, -56.23 80.62, -14.35 in-out-out SNCioo out-out ActLoopNT-out 10.3489 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -118.54, 114.44 APE9-dihe-na -89.96, 150.08 APE8-dihe-in -65.08, 137.29 APE8-rot-in 294.76 APE67-dihe-in -63.71, -21.71 -110.97, 4.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7014 C162S None None XRAY 1.35 0.232 0.253 A 360.0 347.0 7 25 18 7 [[24, 308]] 1.0 6ycu Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
OTHER EIF2AK3 E2AK3_MOUSE 3QD2B Q9Z2B5 582 1078 1114.0 No_ligand No_ligand Inactive DFGin 6.7724 14.1264 None -150.06, 46.53 -144.12, 85.35 -92.69, 31.02 296.57, 72.54 -64.49, -13.2 in-in in 8.8002 Saltbr-in 3.0494 HRD-in -78.7, -42.73 44.71, 30.97 in-in-out SNCiio in-out ActLoopNT-in 2.6916 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_iiin APE10-dihe-na -139.11, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 13.91 APE8-rot-out 183.4 APE67-dihe-out -53.62, -40.83 54.78, -116.69 APE12-dist-in 11.9859 APE11-dist-in 12.2601 APE10-dist-in 7.0504 APE9-dist-none 999.0 None TPO980 TPO980 XRAY 2.81 0.273 0.332 B 332.0 272.0 60 40 25 15 [[382, 1075]] 1.0 3qd2 Mus musculus OTHER_EIF2AK3_MOUSE OTHER 5e-49 173.1 2.0 254.0 253.0 952 953 954 956 958 618 635 639 932 934 933 935.0 1004 992 987 986 985 984 983 982 981 887 Eukaryotic translation initiation factor 2-alpha kinase 3
STE STK39 STK39_MOUSE 5DBXA Q9Z1W9 65 365 556.0 ANP:401 ATPlike Inactive DFGin 6.8713 15.5873 None -61.74, 151.25 -53.68, 129.38 -99.47, -2.77 72.69, 109.41 -58.5, -56.73 out-out out 16.0249 Saltbr-out 17.4351 HRD-in -69.21, -49.56 75.54, -19.7 out-out-out SNCooo out-out ActLoopNT-out 5.6736 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -90.7, -9.1 APE9-dihe-na -96.35, 164.45 APE8-dihe-in -91.01, 125.18 APE8-rot-in 324.0 APE67-dihe-in -65.76, -19.67 -49.27, -43.15 APE12-dist-none 999.0 APE11-dist-out 25.0408 APE10-dist-out 28.2167 APE9-dist-out 27.3477 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 A 328.0 288.0 13 33 20 13 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5DBXB Q9Z1W9 65 364 556.0 ANP:401 ATPlike Inactive DFGin 6.3307 15.0679 None -67.52, 160.16 -60.64, 125.44 -102.44, -1.98 62.33, 96.08 -52.97, -52.55 out-out out 14.0364 Saltbr-out 13.266 HRD-in -73.49, -48.67 74.98, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.6752 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -104.19, 109.41 APE9-dihe-na 87.86, -153.92 APE8-dihe-in -128.52, 139.93 APE8-rot-in 317.58 APE67-dihe-in -74.81, -17.12 -52.01, -48.65 APE12-dist-none 999.0 APE11-dist-out 25.567 APE10-dist-out 25.1599 APE9-dist-out 27.7398 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 B 328.0 286.0 14 33 23 10 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK3 RIPK3_MOUSE 9IWYB Q9QZL0 15 311 486.0 A1D97:60401 Type1 Inactive DFGin 6.9678 14.0618 None -141.15, 157.34 72.96, -21.93 37.23, 42.97 300.12, 81.7 83.46, 13.22 in-none in 9.1083 Saltbr-none 999.0 HRD-in -65.47, -42.38 68.5, -9.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -44.45 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.27 0.299 B 325.0 249.0 48 34 11 23 [[20, 290]] 1.0 9iwy Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LFVB Q9QZL0 14 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.0186 14.0765 None -145.36, 167.9 72.34, -50.6 63.07, 38.87 298.34, 85.19 73.03, 11.82 out-out out 13.2292 Saltbr-out 11.3207 HRD-in -75.72, -32.7 64.15, -13.21 out-out-none SNCoon out-none ActLoopNT-out 11.1831 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -75.83, -8.32 999.0, 22.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 B 325.0 256.0 42 34 14 20 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LFVC Q9QZL0 14 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.0132 13.8713 None -142.11, 177.11 62.46, -56.12 66.46, 24.11 299.69, 104.14 92.05, 19.19 out-none out 13.5118 Saltbr-none 999.0 HRD-in -83.63, -35.26 71.15, -28.83 none-out-none SNCnon out-none ActLoopNT-out 11.3085 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.07, -0.33 999.0, 20.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 C 325.0 250.0 48 34 13 21 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LFVD Q9QZL0 13 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.0646 13.893 None -144.3, 176.32 70.73, -56.46 59.33, 41.69 299.17, 86.38 64.18, 23.93 out-none out 14.4012 Saltbr-none 999.0 HRD-in -78.46, -41.38 66.14, 7.65 none-out-none SNCnon out-none ActLoopNT-out 11.2611 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.45 APE8-rot-none 999.0 APE67-dihe-in -71.04, -19.34 -115.22, 23.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 D 325.0 255.0 44 34 14 20 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LFVA Q9QZL0 13 311 486.0 A1EJO:60401,A1EJP:60402 Type1,Type1 Inactive DFGin 7.3303 14.1402 None -146.0, 165.54 71.61, -51.04 65.28, 34.98 298.07, 86.12 73.14, 14.66 out-none out 13.2609 Saltbr-none 999.0 HRD-in -73.78, -36.28 68.29, -16.9 none-out-out SNCnoo out-out ActLoopNT-out 11.3875 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 42.16 APE8-dihe-in -76.77, 175.03 APE8-rot-none 999.0 APE67-dihe-in -74.57, -14.2 -136.84, 23.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0663 None None None XRAY 2.78 0.249 0.28 A 325.0 259.0 40 34 16 18 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR EPHA4 EPHA4_MOUSE 2Y6MA Q03137 609 891 986.0 No_ligand No_ligand Inactive DFGin 6.0821 15.1035 None -124.48, -160.87 67.79, 62.91 -108.47, 999.0 294.78, 105.52 999.0, 999.0 in-in in 8.2842 Saltbr-in 3.23 HRD-in -72.28, -48.83 78.34, -12.81 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.74 APE8-rot-na 31.74 APE67-dihe-in -75.57, -4.4 -48.65, -50.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.176 0.203 A 291.0 262.0 21 31 10 21 [[621, 880]] 1.0 2y6m Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
TYR EPHA4 EPHA4_MOUSE 2Y6OA Q03137 609 891 986.0 1N1:1892 Type1 Inactive DFGin 6.5237 15.3156 None -125.69, -163.2 68.45, 65.65 -111.22, 999.0 295.37, 106.51 999.0, 999.0 in-in in 8.2042 Saltbr-in 2.6896 HRD-in -74.99, -48.94 76.82, -16.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.47 APE8-dihe-in -69.65, 86.1 APE8-rot-na 27.26 APE67-dihe-in -78.79, 0.73 -48.0, -50.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6377 None None None XRAY 1.543 0.181 0.201 A 291.0 263.0 20 31 11 20 [[621, 880]] 1.0 2y6o Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
TYR EPHA4 EPHA4_MOUSE 2XYUA Q03137 612 891 986.0 Q9G:1898 Type1.5_Back Inactive DFGin 6.3198 15.1855 None -125.63, -157.19 61.91, 64.04 -108.95, 999.0 298.3, 101.76 999.0, 999.0 in-out in 8.6238 Saltbr-out 3.6792 HRD-in -75.11, -49.97 80.15, -19.41 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -122.04 APE8-dihe-in -73.35, 87.97 APE8-rot-na 33.09 APE67-dihe-in -58.55, -20.01 -45.52, -53.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.5889 None None None XRAY 2.117 0.192 0.23 A 285.0 260.0 20 31 11 20 [[621, 880]] 1.0 2xyu Mus musculus TYR_EPHA4_MOUSE TYR 1.5e-109 371.3 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
TYR EPHB2 EPHB2_MOUSE 1JPAA P54763 594 892 986.0 ANP:60400 ATPlike Inactive DFGin 5.7088 15.4887 None -134.81, -163.21 68.34, 57.99 -95.68, 999.0 294.45, 106.32 999.0, 999.0 in-in in 7.779 Saltbr-in 3.0192 HRD-in -67.2, -47.6 76.65, -18.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.15 APE8-rot-na 35.93 APE67-dihe-in -72.25, 3.83 -49.21, -49.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 A 312.0 273.0 26 33 10 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 1JPAB P54763 594 891 986.0 ANP:60401 ATPlike Inactive DFGin 5.7317 15.6268 None -133.42, -158.93 64.89, 61.18 -100.9, 999.0 292.25, 96.96 999.0, 999.0 in-in in 7.8146 Saltbr-in 2.6861 HRD-in -67.92, -50.57 78.02, -16.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.77 APE8-rot-na 326.13 APE67-dihe-in -71.91, 4.89 -51.95, -48.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 B 312.0 269.0 29 33 10 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR JAK1-12 JAK1_MOUSE 7T6FA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.8989 13.8131 None -86.13, -125.98 -78.37, 170.67 -132.74, 42.36 300.4, 95.7 -63.52, -44.16 in-out in 8.2656 Saltbr-out 5.3454 HRD-in -74.55, -24.53 68.9, -7.15 out-in-out SNCoio in-out ActLoopNT-in 3.3664 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.97, -30.61 APE9-dihe-in -69.86, 145.09 APE8-dihe-in -65.5, 154.45 APE8-rot-na 337.81 APE67-dihe-in -111.81, 34.03 -69.03, -47.03 APE12-dist-na 13.0701 APE11-dist-na 13.989 APE10-dist-na 8.6737 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 A 1173.0 1043.0 23 31 31 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 7T6FB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.8984 13.8132 None -86.09, -125.95 -78.45, 170.72 -132.73, 42.29 300.45, 95.61 -63.42, -44.2 in-out in 8.2667 Saltbr-out 5.3471 HRD-in -74.65, -24.42 68.9, -7.11 out-in-out SNCoio in-out ActLoopNT-in 3.3661 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.91, -30.65 APE9-dihe-in -69.79, 145.09 APE8-dihe-in -65.5, 154.47 APE8-rot-na 337.81 APE67-dihe-in -111.9, 34.05 -69.03, -46.98 APE12-dist-na 13.0694 APE11-dist-na 13.9887 APE10-dist-na 8.6729 APE9-dist-in 6.3604 None None None EM 3.6 999.0 999.0 B 1173.0 1043.0 23 31 31 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
OTHER PKNB PKNB_MYCTU 2FUMC P9WI81 3 278 626.0 MIX:2539 Type1 Inactive DFGin 6.7878 14.8635 None -107.89, 177.03 62.6, 100.21 -107.18, 999.0 281.46, 57.46 999.0, 999.0 in-out in 8.6071 Saltbr-out 3.6832 HRD-in -81.39, -39.9 72.99, -11.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -167.24, 35.45 999.0, 145.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.89 0.221 0.278 C 299.0 254.0 22 31 9 22 [[11, 273]] 1.0 2fum Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 6.4e-46 162.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNF PKNF_MYCTU 7NAAA P9WI75 3 278 476.0 V17:600 Type1 Inactive DFGin 7.7664 16.4453 None -112.2, 163.88 72.45, 37.21 -60.92, 999.0 258.19, 101.89 999.0, 999.0 out-none out 12.9162 Saltbr-none 999.0 HRD-in -69.89, -56.45 85.3, -7.85 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.62 APE8-rot-out 181.35 APE67-dihe-in -63.12, -31.84 -114.62, 2.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.239 0.279 A 278.0 244.0 32 30 10 20 [[12, 267]] 1.0 7naa Mycobacterium tuberculosis OTHER_PKNF_MYCTU STE 1.2e-34 125.8 2.0 246.0 245.0 158 159 160 162 164 41 60 64 134 136 135 137.0 200 188 183 182 181 180 179 178 177 90 Serine/threonine-protein kinase PknF
OTHER PKNF PKNF_MYCTU 7NAAB P9WI75 3 278 476.0 V17:600 Type1 Inactive DFGin 7.4177 16.5949 None -114.27, 168.92 71.71, 39.27 -62.75, 999.0 268.87, 95.33 999.0, 999.0 out-none out 12.8665 Saltbr-none 999.0 HRD-in -67.45, -56.53 84.54, -6.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na -78.82, 72.55 APE9-dihe-na -80.85, -149.02 APE8-dihe-in -78.11, 81.4 APE8-rot-none 999.0 APE67-dihe-in -60.78, -32.32 -74.67, -0.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7484 None None None XRAY 2.75 0.239 0.279 B 278.0 242.0 34 30 13 17 [[12, 267]] 1.0 7naa Mycobacterium tuberculosis OTHER_PKNF_MYCTU STE 1.2e-34 125.8 2.0 246.0 245.0 158 159 160 162 164 41 60 64 134 136 135 137.0 200 188 183 182 181 180 179 178 177 90 Serine/threonine-protein kinase PknF
OTHER PKNF PKNF_MYCTU 7NAAC P9WI75 24 278 476.0 V17:600 Type1 Inactive DFGin 7.0903 17.2267 None -115.54, 167.53 69.83, 39.44 -59.86, 999.0 246.36, 96.78 999.0, 999.0 out-none out 11.1454 Saltbr-none 999.0 HRD-in -68.86, -54.99 86.29, -8.12 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.94 APE8-rot-out 180.81 APE67-dihe-in -58.59, -31.71 -117.18, 5.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.239 0.279 C 278.0 217.0 50 30 10 20 [[12, 267]] 1.0 7naa Mycobacterium tuberculosis OTHER_PKNF_MYCTU STE 1.2e-34 125.8 2.0 246.0 245.0 158 159 160 162 164 41 60 64 134 136 135 137.0 200 188 183 182 181 180 179 178 177 90 Serine/threonine-protein kinase PknF
OTHER PKNF PKNF_MYCTU 7NAAD P9WI75 4 277 476.0 V17:600 Type1 Inactive DFGin 7.6663 17.2179 None -113.76, 166.59 72.03, 37.97 -62.58, 999.0 259.82, 100.49 999.0, 999.0 out-none out 10.5853 Saltbr-none 999.0 HRD-in -71.7, -42.16 79.2, -20.03 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.09 APE8-rot-out 183.09 APE67-dihe-in -61.16, -30.28 -118.68, 8.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.239 0.279 D 278.0 234.0 40 30 10 20 [[12, 267]] 1.0 7naa Mycobacterium tuberculosis OTHER_PKNF_MYCTU STE 1.2e-34 125.8 2.0 246.0 245.0 158 159 160 162 164 41 60 64 134 136 135 137.0 200 188 183 182 181 180 179 178 177 90 Serine/threonine-protein kinase PknF
OTHER PAN3 PAN3_NEUCR 4BWKA Q7SDP4 235 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.4954 13.0897 None -115.86, 18.21 -139.38, 20.36 -67.09, 152.08 286.46, 999.0 74.54, -4.0 out-na out 14.2196 Saltbr-na 999.0 HRD-in -64.9, -42.26 69.75, -63.5 na-out-na SNCaoa out-na ActLoopNT-out 6.8983 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -56.05, -33.42 APE9-dihe-na -88.79, -48.0 APE8-dihe-na -71.22, -9.91 APE8-rot-na 304.05 APE67-dihe-na -61.19, -29.14 -123.36, 9.46 APE12-dist-na 1.5354 APE11-dist-na 4.8946 APE10-dist-na 5.2051 APE9-dist-na 11.4637 None None None XRAY 3.3 0.254 0.294 A 429.0 392.0 10 15 15 0 [[258, 516]] 1.0 4bwk Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWKB Q7SDP4 235 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.0984 12.8973 None -116.7, 18.5 -139.0, 22.15 -67.02, 151.82 287.13, 999.0 73.49, -6.49 out-na out 13.8627 Saltbr-na 999.0 HRD-in -66.71, -43.56 68.66, -62.54 na-out-na SNCaoa out-na ActLoopNT-out 6.9009 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -57.01, -33.89 APE9-dihe-na -87.36, -45.86 APE8-dihe-na -67.7, -8.98 APE8-rot-na 303.47 APE67-dihe-na -166.92, 999.0 -122.6, 109.05 APE12-dist-na 1.57 APE11-dist-na 4.9263 APE10-dist-na 5.3667 APE9-dist-na 12.4323 None None None XRAY 3.3 0.254 0.294 B 429.0 387.0 14 15 10 5 [[258, 516]] 1.0 4bwk Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYB Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.6364 12.9995 None -108.01, 7.82 -124.9, 18.28 -71.16, 143.54 291.41, 999.0 81.95, -4.35 out-na out 13.9696 Saltbr-na 999.0 HRD-in -64.78, -43.28 69.3, -58.59 na-out-na SNCaoa out-na ActLoopNT-out 7.0417 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -68.73, -37.24 APE9-dihe-na -75.95, -42.57 APE8-dihe-na -71.33, -35.43 APE8-rot-na 302.88 APE67-dihe-na -61.0, -48.02 -101.37, 21.03 APE12-dist-na 1.5444 APE11-dist-na 4.8399 APE10-dist-na 5.8244 APE9-dist-na 11.7693 None None None XRAY 3.4 0.223 0.263 B 429.0 403.0 6 15 15 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYD Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.3891 12.6265 None -108.63, 8.9 -122.37, 20.29 -71.82, 141.42 292.67, 999.0 81.18, -5.38 out-na out 13.9082 Saltbr-na 999.0 HRD-in -65.6, -43.11 68.0, -59.39 na-out-na SNCaoa out-na ActLoopNT-out 6.9602 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.97, -39.27 APE9-dihe-na -74.97, -41.75 APE8-dihe-na -69.88, -35.71 APE8-rot-na 304.18 APE67-dihe-na -59.83, -48.03 -102.6, 21.19 APE12-dist-na 1.5346 APE11-dist-na 4.8332 APE10-dist-na 5.6883 APE9-dist-na 12.0116 None None None XRAY 3.4 0.223 0.263 D 429.0 403.0 6 15 15 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWXA Q7SDP4 234 646 656.0 AGS:1647 ATPlike Pseudo DFGin 7.9417 12.8154 None -114.92, 18.69 -139.36, 20.25 -66.2, 154.39 287.13, 999.0 71.2, -3.87 out-na out 14.696 Saltbr-na 999.0 HRD-in -65.26, -41.46 68.71, -60.85 na-out-na SNCaoa out-na ActLoopNT-out 6.8523 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -57.52, -32.86 APE9-dihe-na -89.29, -47.03 APE8-dihe-na -70.13, -10.67 APE8-rot-na 304.73 APE67-dihe-na -61.75, -33.62 -123.15, 12.73 APE12-dist-na 1.5381 APE11-dist-na 4.8657 APE10-dist-na 5.325 APE9-dist-na 11.9168 L510M,G511P,G512M,T514G,T515A,H516R,L517F None None XRAY 2.85 0.213 0.242 A 429.0 395.0 10 15 15 0 [[258, 516]] 1.0 4bwx Neurospora crassa OTHER_PAN3_NEUCR PAN3 1.1e-59 210.5 4.0 282.0 279.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWXB Q7SDP4 234 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.0622 12.9423 None -115.89, 18.73 -138.78, 21.11 -66.02, 153.84 287.45, 999.0 70.44, -4.24 out-na out 13.5168 Saltbr-na 999.0 HRD-in -64.84, -41.41 68.02, -61.18 na-out-na SNCaoa out-na ActLoopNT-out 6.8899 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -59.2, -32.89 APE9-dihe-na -88.22, -46.65 APE8-dihe-na -69.2, -11.95 APE8-rot-na 305.01 APE67-dihe-na -59.96, -34.44 -124.18, 13.25 APE12-dist-na 1.54 APE11-dist-na 4.8646 APE10-dist-na 5.3607 APE9-dist-na 12.0065 L510M,G511P,G512M,T514G,T515A,H516R,L517F None None XRAY 2.85 0.213 0.242 B 429.0 397.0 6 15 15 0 [[258, 516]] 1.0 4bwx Neurospora crassa OTHER_PAN3_NEUCR PAN3 1.1e-59 210.5 4.0 282.0 279.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PINK1 PINK1_PEDHC 7T3XA E0W1I1 119 573 575.0 No_ligand No_ligand Inactive DFGin 9.0832 15.3275 None -120.36, -70.42 -69.88, 89.38 -85.01, 15.83 278.07, 80.04 -61.99, -24.85 in-in in 8.0329 Saltbr-in 3.2399 HRD-in -65.16, -48.73 62.37, 8.53 in-in-in SNCiii in-in ActLoopNT-in 2.8506 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -173.08, -178.78 APE9-dihe-na -86.9, -67.98 APE8-dihe-in -69.61, 90.7 APE8-rot-na 192.26 APE67-dihe-in -65.06, -61.21 -69.1, -21.75 APE12-dist-in 9.2026 APE11-dist-in 11.0695 APE10-dist-in 6.8401 APE9-dist-in 4.3333 D334A None None XRAY 3.53 0.218 0.249 A 463.0 399.0 31 34 34 0 [[64, 514]] 1.0 7t3x Pediculus humanus OTHER_PINK1_PEDHC PINK1 1.6e-85 293.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
CMGC PK6 Q8IDW1_PLAF7 9CMZA Q8IDW1 4 294 305.0 A1AZE:405 Type1 Inactive DFGin 5.9578 12.5997 None -94.14, -157.81 -38.02, 124.16 -88.24, 13.86 299.83, 1.24 -70.53, -12.65 in-in in 9.1302 Saltbr-in 2.8519 HRD-in -80.4, -44.87 68.81, 6.06 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -67.42, -47.85 APE9-dihe-na -56.07, 137.1 APE8-dihe-in -48.14, 142.29 APE8-rot-in 301.26 APE67-dihe-in -63.45, -19.54 -54.62, -52.55 APE12-dist-in 13.528 APE11-dist-in 11.9916 APE10-dist-in 6.3177 APE9-dist-in 3.5559 C44N,C53R,K86A,C222N,K237A None None XRAY 2.45 0.221 0.255 A 306.0 278.0 13 25 25 0 [[9, 293]] 1.0 9cmz Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.2e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CMGC PK6 Q8IDW1_PLAF7 9CMZB Q8IDW1 4 296 305.0 A1AZE:403 Type1 Inactive DFGin 5.9492 12.3581 None -87.61, -154.47 -39.14, 133.87 -103.66, 12.02 299.03, 6.05 -77.37, -6.63 in-in in 9.3411 Saltbr-in 2.7516 HRD-in -77.49, -49.61 70.86, 8.17 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -64.12, -41.81 APE9-dihe-na -63.53, 145.63 APE8-dihe-in -55.7, 134.62 APE8-rot-in 319.67 APE67-dihe-in -64.53, -20.52 -45.12, -48.09 APE12-dist-in 13.2082 APE11-dist-in 11.7673 APE10-dist-in 6.036 APE9-dist-in 3.6503 C44N,C53R,K86A,C222N,K237A None None XRAY 2.45 0.221 0.255 B 306.0 284.0 9 25 25 0 [[9, 293]] 1.0 9cmz Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.2e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CMGC PK6 Q8IDW1_PLAF7 9CMZC Q8IDW1 4 295 305.0 A1AZE:402 Type1 Inactive DFGin 6.0911 13.2991 None -103.9, -129.12 -42.46, 117.59 -94.29, 9.37 297.87, 3.31 -71.04, -2.09 in-none in 9.7093 Saltbr-none 999.0 HRD-in -71.55, -46.08 68.76, 6.39 none-in-in SNCnii in-in ActLoopNT-in 2.8638 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.14, -45.59 APE9-dihe-na -71.51, 142.15 APE8-dihe-in -54.87, 141.86 APE8-rot-in 290.82 APE67-dihe-in -54.29, -32.67 -58.55, -41.7 APE12-dist-in 13.1707 APE11-dist-in 11.8463 APE10-dist-in 6.3518 APE9-dist-in 3.1273 C44N,C53R,K86A,C222N,K237A None None XRAY 2.45 0.221 0.255 C 306.0 271.0 21 25 25 0 [[9, 293]] 1.0 9cmz Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.2e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CMGC PK6 Q8IDW1_PLAF7 8U2OA Q8IDW1 1 298 305.0 V3O:60405 Type1 Inactive DFGin 5.8965 12.5105 None -94.96, -148.98 -42.04, 131.33 -95.74, 12.17 304.54, 179.87 -67.72, -14.66 in-in in 9.5513 Saltbr-in 2.5363 HRD-in -78.09, -50.71 66.76, 14.89 in-in-in SNCiii in-in ActLoopNT-in 2.8753 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -72.6, -44.34 APE9-dihe-na -64.9, 136.38 APE8-dihe-in -57.5, 138.34 APE8-rot-in 311.13 APE67-dihe-in -57.61, -26.63 -51.17, -51.11 APE12-dist-in 13.3021 APE11-dist-in 11.6241 APE10-dist-in 6.0228 APE9-dist-in 3.4997 C44N,C53R,K86A,C222N,K237A None None XRAY 2.15 0.221 0.281 A 307.0 287.0 10 25 25 0 [[9, 293]] 1.0 8u2o Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.3e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CMGC PK6 Q8IDW1_PLAF7 8U2OB Q8IDW1 4 294 305.0 V3O:60405 Type1 Inactive DFGin 5.8335 12.5651 None -95.64, -148.11 -40.43, 130.23 -98.6, 12.15 305.65, 177.87 -65.69, -13.43 in-in in 9.5275 Saltbr-in 2.6266 HRD-in -80.22, -50.28 65.88, 13.5 in-in-out SNCiio in-out ActLoopNT-in 2.8247 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -75.1, -40.16 APE9-dihe-na -65.58, 130.1 APE8-dihe-in -62.82, 145.01 APE8-rot-out 89.31 APE67-dihe-in -59.91, -27.62 -49.15, -51.42 APE12-dist-in 13.4102 APE11-dist-in 11.7273 APE10-dist-in 6.0201 APE9-dist-in 3.4878 C44N,C53R,K86A,C222N,K237A None None XRAY 2.15 0.221 0.281 B 307.0 276.0 15 25 25 0 [[9, 293]] 1.0 8u2o Plasmodium falciparum CMGC_PK6_PLAF7 CMGC 5.3e-69 244.5 3.0 300.0 298.0 160 161 162 164 166 38 57 61 140 142 141 143.0 198 185 180 179 178 177 176 175 174 100 Cyclin-dependent kinase 2 homolog
CAMK CAMK1 KCC1A_RAT 1A06A Q63450 10 316 374.0 No_ligand No_ligand Inactive DFGin 8.5304 16.8416 None -78.3, -91.42 -50.6, 142.58 -174.46, 999.0 235.15, 89.5 999.0, 999.0 out-out out 12.8717 Saltbr-out 7.404 HRD-in -69.28, -53.46 75.23, -43.11 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -58.93, -19.88 999.0, -121.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.201 0.313 A 332.0 279.0 28 27 9 18 [[20, 276]] 1.0 1a06 Rattus norvegicus CAMK_CAMK1_RAT CAMK 7e-97 329.9 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK MARK2 MARK2_RAT 2R0IA O08679 48 363 722.0 No_ligand No_ligand Inactive DFGin 7.1773 15.9104 None -110.07, 163.19 70.79, 104.32 -114.32, 999.0 271.35, 82.41 999.0, 999.0 in-in in 9.8103 Saltbr-in 2.9222 HRD-in -72.72, -53.9 78.71, -16.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 32.87 APE8-dihe-out -80.28, -35.43 APE8-rot-out 33.61 APE67-dihe-in -54.73, -18.4 -55.05, -40.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5684 E318A None None XRAY 2.202 0.194 0.239 A 327.0 300.0 16 27 11 16 [[53, 304]] 1.0 2r0i Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2R0IB O08679 48 363 722.0 No_ligand No_ligand Inactive DFGin 7.288 15.7457 None -106.65, 164.03 58.05, 102.65 -104.54, 999.0 278.98, 72.06 999.0, 999.0 in-in in 9.6682 Saltbr-in 3.0026 HRD-in -63.83, -55.97 76.75, -7.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 34.5 APE8-dihe-out -80.07, -37.66 APE8-rot-out 40.75 APE67-dihe-in -61.42, -16.77 -41.08, -47.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.655 E318A None None XRAY 2.202 0.194 0.239 B 327.0 300.0 16 27 11 16 [[53, 304]] 1.0 2r0i Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2WZJA O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.2964 19.4429 None -98.71, 167.47 67.78, 27.22 -75.76, -39.27 231.0, 117.88 -107.13, -80.77 out-none out 11.1414 Saltbr-none 999.0 HRD-in -75.15, -47.64 70.01, -6.03 none-out-out SNCnoo out-out ActLoopNT-out 13.503 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -55.72, 133.56 APE9-dihe-na 78.12, -13.87 APE8-dihe-out -67.74, -43.04 APE8-rot-in 291.97 APE67-dihe-in -62.19, -15.93 -58.96, -43.73 APE12-dist-out 17.5862 APE11-dist-out 15.426 APE10-dist-out 16.7267 APE9-dist-out 10.8809 K82R,T208E None None XRAY 2.786 0.182 0.246 A 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2WZJB O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.655 19.1179 None -108.74, 166.92 70.33, 31.17 -81.88, -31.63 237.8, 118.28 -103.58, -84.38 out-none out 11.2946 Saltbr-none 999.0 HRD-in -73.51, -48.16 74.26, -7.23 none-out-out SNCnoo out-out ActLoopNT-out 13.3405 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -55.83, 119.56 APE9-dihe-na 97.8, -31.81 APE8-dihe-out -52.01, -40.59 APE8-rot-in 301.14 APE67-dihe-in -59.16, -17.79 -69.83, -40.48 APE12-dist-out 17.7834 APE11-dist-out 15.6951 APE10-dist-out 17.0451 APE9-dist-out 10.6569 K82R,T208E None None XRAY 2.786 0.182 0.246 B 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2WZJE O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.7278 19.4523 None -122.21, 167.3 70.37, 14.54 -64.86, -52.55 239.49, 125.08 -92.23, -103.55 out-none out 11.2743 Saltbr-none 999.0 HRD-in -71.5, -43.46 73.23, -7.58 none-out-out SNCnoo out-out ActLoopNT-out 13.576 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -54.24, 120.43 APE9-dihe-na 88.28, -0.67 APE8-dihe-out -78.27, -40.76 APE8-rot-in 286.92 APE67-dihe-in -59.78, -9.34 -58.65, -47.75 APE12-dist-out 18.0861 APE11-dist-out 15.9972 APE10-dist-out 17.2602 APE9-dist-out 11.1331 K82R,T208E None None XRAY 2.786 0.182 0.246 E 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_RAT 2WZJF O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.4161 19.3297 None -128.0, 171.74 60.39, 39.11 -82.16, -33.66 235.83, 116.83 -109.02, -81.73 out-none out 11.4062 Saltbr-none 999.0 HRD-in -70.32, -50.59 74.66, -7.6 none-out-out SNCnoo out-out ActLoopNT-out 13.3181 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -47.39, 112.51 APE9-dihe-na 95.61, -12.53 APE8-dihe-out -65.97, -50.18 APE8-rot-in 297.4 APE67-dihe-in -68.54, -20.61 -50.47, -43.86 APE12-dist-out 17.1694 APE11-dist-out 15.1773 APE10-dist-out 16.4228 APE9-dist-out 10.9122 K82R,T208E None None XRAY 2.786 0.182 0.246 F 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK PRKAA1 AAPK1_RAT 4CFHA P54645 21 481 559.0 STU:61550 Type1 Inactive DFGin 6.6088 14.765 None -117.21, -79.88 -80.17, 112.56 -105.2, 27.91 278.75, 78.83 -62.93, -29.8 in-in in 9.2938 Saltbr-in 2.6645 HRD-out -123.7, 94.84 -71.28, 163.89 in-in-out SNCiio in-out ActLoopNT-in 3.0286 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -124.99, -9.44 APE9-dihe-na -61.07, -171.7 APE8-dihe-in -76.22, 167.06 APE8-rot-in 301.11 APE67-dihe-out -88.03, -177.87 -58.32, -48.27 APE12-dist-in 8.3547 APE11-dist-in 10.8638 APE10-dist-in 5.2822 APE9-dist-out 6.0779 None TPO183,TPO388 TPO183,TPO388 XRAY 3.24 0.234 0.268 A 493.0 402.0 0 27 27 0 [[27, 279]] 1.0 4cfh Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5KQ5A P54645 21 559 559.0 STU:60601,6VT:60602 Type1,Allosteric Inactive DFGin 7.4725 14.6042 None -132.46, -37.52 -94.52, 85.46 -82.34, 16.94 281.45, 80.99 -67.49, -33.4 in-in in 9.8975 Saltbr-in 3.2515 HRD-out -71.96, 95.28 -74.85, 167.58 in-in-out SNCiio in-out ActLoopNT-in 2.8817 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -101.64, 146.06 APE9-dihe-na 119.59, 166.41 APE8-dihe-in -64.65, 139.74 APE8-rot-out 166.73 APE67-dihe-in -69.09, -28.51 -58.99, -33.91 APE12-dist-in 7.8697 APE11-dist-in 11.3589 APE10-dist-in 5.426 APE9-dist-out 6.0759 None TPO183 TPO183 XRAY 3.41 0.223 0.259 A 503.0 363.0 0 27 27 0 [[27, 279]] 1.0 5kq5 Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CMGC MAPK1 MK01_RAT 6FJZA P63086 9 354 358.0 DKW:402 Type1 Inactive DFGin 6.6634 16.4202 None -134.8, -179.27 82.46, -86.27 66.98, 18.08 291.18, 83.08 -68.21, -20.47 in-in in 9.2842 Saltbr-in 2.7213 HRD-in -71.29, -49.89 75.9, -0.67 in-in-out SNCiio in-out ActLoopNT-in 2.7431 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -99.27, -45.48 APE9-dihe-na -54.12, 158.83 APE8-dihe-in -55.9, 129.11 APE8-rot-in 307.1 APE67-dihe-in -60.37, -17.39 -59.77, -49.92 APE12-dist-out 14.2719 APE11-dist-in 11.2255 APE10-dist-in 7.301 APE9-dist-in 4.4081 None None CME159 XRAY 1.864 0.174 0.207 A 364.0 346.0 0 31 31 0 [[23, 311]] 1.0 6fjz Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CAMK RAD53 RAD53_YEAST 5XZVA P22216 16 465 821.0 ANP:60501 ATPlike Inactive DFGin 7.0643 15.2612 None -121.2, -53.4 -91.08, 125.25 -116.1, 93.37 279.98, 81.22 -112.86, 58.45 in-out in 9.8831 Saltbr-out 4.1817 HRD-out -106.71, 124.14 -85.03, 170.27 out-out-none SNCoon out-none ActLoopNT-out 5.5013 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.22, -40.45 999.0, 55.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.273 0.289 A 471.0 375.0 42 27 13 14 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK SNF1 SNF1_YEAST 3HYHA P06782 54 315 633.0 No_ligand No_ligand Inactive DFGin 6.0984 16.7656 None -111.12, -13.11 -126.17, -61.58 79.91, 6.5 296.33, 106.43 140.74, -39.38 in-out in 9.3906 Saltbr-out 7.4467 HRD-in -72.58, -57.94 75.21, 1.42 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.98, -16.07 999.0, -51.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.241 0.28 A 275.0 238.0 24 27 12 15 [[55, 306]] 1.0 3hyh Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 6.9e-92 313.3 1.0 256.0 256.0 194 195 196 198 200 84 103 107 174 176 175 177.0 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
CAMK SNF1 SNF1_YEAST 3HYHB P06782 54 315 633.0 No_ligand No_ligand Inactive DFGin 5.4319 16.1058 None -106.08, -19.55 -134.22, -49.92 72.17, 2.2 308.78, 105.92 154.63, -57.75 in-out in 9.2973 Saltbr-out 9.3361 HRD-in -71.53, -49.18 67.86, -7.04 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.94, -15.46 999.0, -20.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.241 0.28 B 275.0 233.0 29 27 12 15 [[55, 306]] 1.0 3hyh Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 6.9e-92 313.3 1.0 256.0 256.0 194 195 196 198 200 84 103 107 174 176 175 177.0 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
CAMK SNF1 SNF1_YEAST 3DAEA P06782 48 315 633.0 No_ligand No_ligand Inactive DFGin 6.2177 16.202 None -125.2, -22.46 -94.07, -93.42 89.8, 999.0 293.71, 96.49 999.0, 999.0 in-out in 8.8598 Saltbr-out 6.4233 HRD-in -64.28, -60.04 81.75, -19.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 169.41 APE8-dihe-in -109.2, 134.01 APE8-rot-out 65.28 APE67-dihe-in -77.3, -18.85 -73.8, -6.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9096 None None None XRAY 2.899 0.229 0.265 A 283.0 248.0 20 27 11 16 [[55, 306]] 1.0 3dae Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 7.7e-92 313.1 1.0 256.0 256.0 194 195 196 198 200 84 103 107 174 176 175 177.0 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
CAMK SNF1 SNF1_YEAST 3DAEB P06782 50 315 633.0 No_ligand No_ligand Inactive DFGin 6.3629 15.9617 None -127.08, -17.05 -95.64, -97.19 92.94, 999.0 297.43, 95.41 999.0, 999.0 in-out in 8.9693 Saltbr-out 7.3816 HRD-in -71.27, -60.85 84.49, -11.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 93.59 APE8-dihe-in -114.5, 143.48 APE8-rot-out 65.27 APE67-dihe-in -79.74, -11.6 -115.06, 12.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1443 None None None XRAY 2.899 0.229 0.265 B 283.0 246.0 20 27 11 16 [[55, 306]] 1.0 3dae Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 7.7e-92 313.1 1.0 256.0 256.0 194 195 196 198 200 84 103 107 174 176 175 177.0 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
OTHER PAN3-12 PAN3_YEAST 4XR7B P36102 226 679 679.0 No_ligand No_ligand Pseudo DFGin 8.5025 15.4217 None -104.85, -81.9 -55.51, -45.21 62.67, 17.87 199.85, 999.0 45.47, 46.6 out-na out 13.4903 Saltbr-na 999.0 HRD-out -76.12, -16.46 -97.99, 85.58 na-out-na SNCaoa out-na ActLoopNT-out 8.9448 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.19, 130.31 APE9-dihe-na -74.85, 162.0 APE8-dihe-na -74.39, -32.88 APE8-rot-na 188.94 APE67-dihe-na -124.14, 114.63 -58.03, 146.49 APE12-dist-na 11.2874 APE11-dist-na 13.8798 APE10-dist-na 13.5452 APE9-dist-na 21.3537 None None None XRAY 3.796 0.286 0.299 B 465.0 427.0 8 21 18 3 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7E P36102 252 679 679.0 No_ligand No_ligand Pseudo DFGin 8.5933 14.5451 None -105.54, -82.28 -61.73, -45.08 66.71, 24.92 201.84, 999.0 57.11, 56.18 out-na out 12.9797 Saltbr-na 999.0 HRD-out -76.76, -25.26 -92.98, 20.24 na-out-na SNCaoa out-na ActLoopNT-out 8.9533 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -151.67, 137.7 APE9-dihe-na -156.27, 147.39 APE8-dihe-na 50.58, -115.32 APE8-rot-na 999.0 APE67-dihe-na -120.31, 161.36 -52.5, 149.39 APE12-dist-na 10.4227 APE11-dist-na 14.3995 APE10-dist-na 13.0607 APE9-dist-na 22.1966 None None None XRAY 3.796 0.286 0.299 E 465.0 414.0 14 21 17 4 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7F P36102 228 679 679.0 No_ligand No_ligand Pseudo DFGin 7.3351 13.9922 None -85.2, -83.41 -116.11, 146.78 -89.94, 10.94 48.78, 999.0 50.83, 40.11 out-na out 14.008 Saltbr-na 999.0 HRD-out -81.05, -16.69 -95.9, 8.11 na-out-na SNCaoa out-na ActLoopNT-out 9.4022 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -60.89, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 14.4938 APE11-dist-na 13.2541 APE10-dist-na 14.3861 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 F 465.0 442.0 10 21 12 9 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7H P36102 250 679 679.0 No_ligand No_ligand Pseudo DFGin 8.6796 13.3004 None -110.24, -81.52 -76.76, -38.07 62.46, 20.88 310.53, 999.0 54.16, 56.32 out-na out 12.9207 Saltbr-na 999.0 HRD-out -76.61, -35.33 -92.88, 18.01 na-out-na SNCaoa out-na ActLoopNT-out 8.4985 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.22, 105.17 APE9-dihe-na -135.67, 109.97 APE8-dihe-na -101.57, -1.61 APE8-rot-na 999.0 APE67-dihe-na -115.02, 104.33 50.65, 25.81 APE12-dist-na 10.2 APE11-dist-na 15.2541 APE10-dist-na 16.0733 APE9-dist-na 20.3565 None None None XRAY 3.796 0.286 0.299 H 465.0 420.0 10 21 21 0 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7I P36102 229 679 679.0 No_ligand No_ligand Pseudo DFGin 8.1436 12.4336 None -108.56, -80.67 -51.19, -43.4 36.07, 999.0 50.25, 999.0 999.0, 999.0 out-na out 13.8264 Saltbr-na 999.0 HRD-out -73.52, 162.17 61.84, 30.5 na-out-na SNCaoa out-na ActLoopNT-out 8.9846 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 14.2752 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 I 465.0 437.0 14 21 9 12 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7K P36102 232 679 679.0 No_ligand No_ligand Pseudo DFGin 8.8667 14.9228 None -156.42, 150.14 71.91, -27.38 40.67, 30.2 203.09, 999.0 55.41, 54.89 out-na out 12.9021 Saltbr-na 999.0 HRD-out -76.01, -11.95 -99.49, 85.37 na-out-na SNCaoa out-na ActLoopNT-out 9.2524 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -146.25, 136.7 APE9-dihe-na -119.48, 142.98 APE8-dihe-na -86.15, 136.33 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 -173.56, 999.0 APE12-dist-na 10.2176 APE11-dist-na 14.3981 APE10-dist-na 13.3286 APE9-dist-na 21.6671 None None None XRAY 3.796 0.286 0.299 K 465.0 430.0 12 21 15 6 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7L P36102 228 679 679.0 No_ligand No_ligand Pseudo DFGin 6.6712 13.6853 None -78.56, -72.57 -129.25, 151.61 -94.17, 11.47 47.53, 999.0 54.98, 49.56 out-na out 13.8368 Saltbr-na 999.0 HRD-out -78.34, 152.76 -93.5, 19.59 na-out-na SNCaoa out-na ActLoopNT-out 9.6542 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 11.6156 APE11-dist-na 10.871 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 L 465.0 441.0 11 21 11 10 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 6R5KN P36102 226 679 679.0 No_ligand No_ligand Pseudo DFGin 8.4796 14.6642 None -120.3, -48.75 -78.43, -46.99 64.41, 6.24 198.56, 999.0 58.24, 31.07 out-na out 14.2569 Saltbr-na 999.0 HRD-out -118.35, -63.98 -77.29, 95.53 na-out-na SNCaoa out-na ActLoopNT-out 10.6477 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -133.92, 86.09 APE9-dihe-na -148.85, 91.9 APE8-dihe-na 67.7, -5.31 APE8-rot-na 203.89 APE67-dihe-na -67.7, 108.58 -85.15, -39.73 APE12-dist-na 11.0066 APE11-dist-na 11.8723 APE10-dist-na 10.2258 APE9-dist-na 14.9417 None None None EM 4.8 999.0 999.0 N 458.0 427.0 8 21 18 3 [[284, 397], [394, 557]] 2.0 6r5k Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 3.6e-11 78.1 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 6R5KO P36102 224 679 679.0 No_ligand No_ligand Pseudo DFGin 10.4578 15.6741 None -78.53, -48.76 -98.61, 103.36 -129.36, 83.07 293.03, 999.0 -139.53, -162.35 out-na out 14.0111 Saltbr-na 999.0 HRD-out -70.33, -14.42 -118.0, -56.77 na-out-na SNCaoa out-na ActLoopNT-out 12.3551 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None EM 4.8 999.0 999.0 O 689.0 443.0 13 21 9 12 [[284, 397], [394, 557]] 2.0 6r5k Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 2.8e-11 77.9 1.0 114.0 205.0 444 445 446 448 450 325 342 346 422 425 423 426.0 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PINK1 PINK1_TRICA 7MP9A D6WMX4 121 568 570.0 AN2:609 ATPlike Inactive DFGin 9.4917 15.077 None -107.5, -68.6 -79.29, 107.71 -103.85, 17.12 271.24, 68.18 -70.55, -9.3 in-in in 7.8201 Saltbr-in 2.482 HRD-in -85.61, -44.31 63.96, 13.98 in-in-in SNCiii in-in ActLoopNT-in 2.7063 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 122.7, -149.63 APE9-dihe-na -104.04, -111.12 APE8-dihe-in -65.26, 151.5 APE8-rot-na 80.98 APE67-dihe-in -70.22, -49.9 -101.67, -4.86 APE12-dist-in 7.9325 APE11-dist-in 10.2637 APE10-dist-in 5.6129 APE9-dist-in 3.4397 None SEP205,TPO530 SEP205,TPO530 XRAY 2.8 0.25 0.306 A 455.0 414.0 31 34 34 0 [[61, 504]] 1.0 7mp9 Tribolium castaneum OTHER_PINK1_TRICA PINK1 3.5e-89 305.2 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_TRICA 8UDCA D6WMX4 122 566 570.0 WCK:603 Type1 Inactive DFGin 9.4017 14.9712 None -109.71, -75.95 -80.82, 116.53 -96.35, 38.57 282.73, 77.17 -65.86, -41.7 in-out in 7.7561 Saltbr-out 3.8176 HRD-in -84.54, -42.39 69.78, -6.1 out-in-out SNCoio in-out ActLoopNT-in 2.8586 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iiii APE10-dihe-na 116.87, 89.91 APE9-dihe-na -31.69, 140.62 APE8-dihe-out 95.57, 105.05 APE8-rot-na 175.25 APE67-dihe-in -73.73, -57.88 -95.91, -8.92 APE12-dist-in 7.2371 APE11-dist-in 10.1192 APE10-dist-in 5.5867 APE9-dist-in 4.9123 W131A,W142A,Y144A,I147A,Y225A,Y378A,F401A,F437A None None XRAY 3.1 0.259 0.329 A 455.0 397.0 30 34 34 0 [[61, 504]] 1.0 8udc Tribolium castaneum OTHER_PINK1_TRICA PINK1 1.6e-89 306.3 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_TRICA 8UCTA D6WMX4 122 566 570.0 3YT:604 Type1 Inactive DFGin 9.6675 15.5149 None -106.46, -71.46 -86.94, 98.04 -82.78, 26.92 282.15, 73.59 -69.21, -17.85 in-in in 7.7276 Saltbr-in 3.5456 HRD-in -61.61, -52.71 76.55, -7.29 in-in-in SNCiii in-in ActLoopNT-in 2.8231 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 143.12, -153.91 APE9-dihe-na -114.43, -90.54 APE8-dihe-in -52.28, 116.57 APE8-rot-na 181.23 APE67-dihe-in -80.32, -30.67 -78.6, -18.94 APE12-dist-in 7.6852 APE11-dist-in 9.8751 APE10-dist-in 5.4884 APE9-dist-in 4.262 W131A,W142A,Y225A,Y378A,F401A,F437A None None XRAY 2.93 0.284 0.305 A 455.0 391.0 37 34 34 0 [[61, 504]] 1.0 8uct Tribolium castaneum OTHER_PINK1_TRICA PINK1 1.6e-89 306.3 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
AGC TB0348O8470 Q582V7_TRYB2 9Z8KA Q582V7 54 348 406.0 No_ligand No_ligand Inactive DFGin 8.1173 13.0625 None -69.43, 156.83 -45.73, 116.64 -72.04, -20.66 74.88, 86.04 -64.59, -37.41 in-out in 9.806 Saltbr-out 6.7036 HRD-in -68.62, -41.79 73.54, -21.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.78 APE8-dihe-out -53.88, -45.48 APE8-rot-out 194.69 APE67-dihe-in -78.28, -17.05 -56.7, -29.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2459 None SEP71 SEP71 XRAY 2.05 0.197 0.235 A 362.0 272.0 23 37 14 23 [[61, 326]] 1.0 9z8k Trypanosoma brucei brucei AGC_TB0348O8470_TRYB2 AGC 3.9e-77 264.9 1.0 259.0 259.0 203 204 205 207 209 90 109 113 183 185 184 186.0 252 240 235 234 233 232 231 230 229 139 Serine/threonine-protein kinase, putative
CAMK AURKBA AUKBA_XENLA 4B8LA Q6DE08 87 351 361.0 A0P:1352 Type1 Inactive DFGin 7.5521 15.5639 None -81.6, -93.69 -89.24, 141.54 -107.67, 999.0 288.18, 65.55 999.0, 999.0 out-out out 10.5609 Saltbr-out 5.9445 HRD-in -91.78, -45.75 80.25, -35.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.01 APE8-rot-in 294.25 APE67-dihe-in -54.23, -29.34 -30.25, -64.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P353G None None XRAY 3.0 0.24 0.297 A 286.0 249.0 16 26 10 16 [[93, 343]] 1.0 4b8l Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.6e-77 265.6 1.0 256.0 256.0 233 234 235 237 239 122 141 145 213 215 214 216.0 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A