TTK (Dual specificity protein kinase TTK)

Group: OTHER
Uniprot: TTK_HUMAN
Domain boundary: 525 - 791


Total number of chains: 77
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P33981-K1A
DFGin BLAplus 1 3H9FA
DFGin ABAminus 74 5AP1A
DFGin None 1 7CHMA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
3CEKA 2.3 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 519 - 794 None None 14
3DBQA 2.7 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 515 - 796 None None 12
2ZMCA 3.14 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 516 - 794 None None 9
6GVJA 2.41 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 515 - 795 None None 0
5NTTA 2.75 Inactive DFGin ABAminus out-out out-out SVE Type1 519 - 797 C604Y X686 0
5LJJA 3.0 Inactive DFGin ABAminus out-out out-out AD5 Type1 519 - 795 C604Y None 5
5MRBA 2.2 Inactive DFGin ABAminus out-out out-out C5N Type1 519 - 795 C604Y None 5
5EH0A 2.18 Inactive DFGin ABAminus out-out out-out 5NW Type1 516 - 794 None None 10
6H3KA 2.48 Inactive DFGin ABAminus out-out out-none FMW Type1 519 - 794 None None 12
4JS8A 1.94 Inactive DFGin ABAminus in-out out-out 1PF Type1 515 - 793 None X675,X686 8
4JT3A 2.2 Inactive DFGin ABAminus out-out out-out 1PH Type1 515 - 794 None None 13
4O6LA 2.38 Inactive DFGin ABAminus out-out out-none 2QK Type1 515 - 793 None X675,X676,X677 8
4O6LB 2.38 Inactive DFGin ABAminus out-out out-out 2QK Type1 515 - 793 None X675,X676,X677 11
4ZEGA 2.33 Inactive DFGin ABAminus in-in out-none 052 Type1 516 - 795 None None 11
7CILA 2.3 Inactive DFGin ABAminus in-in out-out FZR Type1 515 - 795 None X686 9
7CHNA 2.4 Inactive DFGin ABAminus in-out out-out FZL Type1 515 - 795 None X675,X676,X677,X686 4
7CHTA 2.4 Inactive DFGin ABAminus in-in out-none FZO Type1 515 - 794 None X675,X676,X677,X686 7
7CJAA 2.49 Inactive DFGin ABAminus in-in out-out G0U Type1 515 - 795 None X675,X676,X677,X686 8
7CLHA 2.9 Inactive DFGin ABAminus out-out out-out G5C Type1 516 - 795 None X675,X676,X677,X686 9
4D2SA 2.5 Inactive DFGin ABAminus out-out none-none DYK Type1 513 - 793 None None 17
6TN9A 2.6 Inactive DFGin ABAminus in-out out-out NN5 Type1 515 - 794 None None 14
6TNCA 2.3 Inactive DFGin ABAminus in-in out-out O23 Type1 516 - 794 None X686 10
6N6OA 2.6 Inactive DFGin ABAminus out-out out-none KE7 Type1 515 - 794 None None 16
3GFWA 2.74 Inactive DFGin ABAminus out-out none-out S22 Type1 519 - 794 None None 16
4BHZA 2.85 Inactive DFGin ABAminus out-out out-out Z0B Type1 519 - 794 None None 12
4BI0A 2.84 Inactive DFGin ABAminus out-out out-out Z0W Type1 519 - 794 None None 12
4BI1A 2.7 Inactive DFGin ABAminus out-out out-out ZO6 Type1 519 - 794 None None 13
4BI2A 3.11 Inactive DFGin ABAminus out-out out-out ZO8 Type1 519 - 794 None None 13
4C4EA 2.6 Inactive DFGin ABAminus out-out out-out 4T9 Type1 519 - 794 None X686 9
4C4FA 2.36 Inactive DFGin ABAminus out-out out-out 7CE Type1 519 - 794 None X686 12
4C4GA 2.65 Inactive DFGin ABAminus out-out none-out 7RO Type1 519 - 794 None X686 15
4C4HA 2.8 Inactive DFGin ABAminus out-out none-none 7RO Type1 519 - 794 None None 17
4C4IA 2.65 Inactive DFGin ABAminus out-out out-none X20 Type1 519 - 794 None None 14
4C4JA 2.5 Inactive DFGin ABAminus in-in out-out X21 Type1 519 - 794 None X686 8
4CV8A 3.0 Inactive DFGin ABAminus out-none out-out 3D7 Type1 519 - 794 None None 13
4CV9A 2.5 Inactive DFGin ABAminus out-out out-out W2K Type1 519 - 794 None X686 14
4CVAA 2.5 Inactive DFGin ABAminus out-out out-out WBI Type1 519 - 794 None X686 14
5AP0A 2.15 Inactive DFGin ABAminus out-out out-out AU5 Type1 519 - 795 None X686 13
5AP1A 2.05 Inactive DFGin ABAminus in-out out-out O38 Type1 519 - 795 None X675,X676,X677,X686 2
5AP2A 2.8 Inactive DFGin ABAminus in-in out-out PWU Type1 519 - 794 None None 10
5EHLA 2.66 Inactive DFGin ABAminus out-none out-out 0SQ Type1 519 - 796 None None 14
5EHOA 2.18 Inactive DFGin ABAminus out-out out-out 5O1 Type1 519 - 794 None None 9
5EHYA 2.26 Inactive DFGin ABAminus out-out out-out 5O4 Type1 519 - 794 None None 13
5EI2A 2.67 Inactive DFGin ABAminus out-out out-out 5O7 Type1 516 - 794 None None 12
5EI6A 2.01 Inactive DFGin ABAminus in-out out-out 5OQ Type1 519 - 794 None None 5
5EI8A 2.17 Inactive DFGin ABAminus out-out out-out 5OE Type1 519 - 753 None None 9
5N87A 2.29 Inactive DFGin ABAminus out-out out-out N66 Type1 519 - 794 None X686 12
5AP6A 2.1 Inactive DFGin ABAminus in-in out-out PWU Type1 519 - 794 C604W None 6
5AP7A 2.45 Inactive DFGin ABAminus out-out out-out SVE Type1 519 - 794 C604W None 10
5O91A 3.2 Inactive DFGin ABAminus out-out out-out C5N Type1 519 - 796 C604W None 6
6B4WA 2.9 Inactive DFGin ABAminus in-none out-out CQ7 Type1 515 - 793 None None 9
2X9EA 3.1 Inactive DFGin ABAminus out-out out-out SVE Type1 515 - 795 None None 15
3VQUA 2.4 Inactive DFGin ABAminus out-out out-out O22 Type1 516 - 795 None None 10
3WYXA 2.9 Inactive DFGin ABAminus in-out out-out O38 Type1 516 - 795 None None 11
3WYYA 3.05 Inactive DFGin ABAminus in-out out-out O17 Type1 516 - 795 None None 11
5N7VA 2.52 Inactive DFGin ABAminus out-out out-out 8PT Type1 519 - 794 None X686 7
5N84A 2.3 Inactive DFGin ABAminus out-out out-out 8Q5 Type1 519 - 794 None None 12
5N93A 2.1 Inactive DFGin ABAminus out-out out-out 8QE Type1 519 - 794 None X686 9
5NA0A 2.9 Inactive DFGin ABAminus out-out out-out 8QZ Type1 519 - 794 None X686 12
3HMNA 2.7 Inactive DFGin ABAminus out-out out-out ATP Type1 516 - 794 None None 12
3HMOA 2.4 Inactive DFGin ABAminus out-out out-out STU Type1 514 - 794 None None 12
3HMPA 2.3 Inactive DFGin ABAminus out-out out-out CX4 Type1 516 - 794 None None 10
5AP3A 2.7 Inactive DFGin ABAminus out-out out-out AU5 Type1 519 - 794 S611G X686 12
5AP4A 2.85 Inactive DFGin ABAminus out-out out-out O38 Type1 519 - 794 S611G X686 9
2ZMDA 2.88 Inactive DFGin ABAminus out-out out-out 537 Type1 516 - 795 T686A None 9
7LQDA 1.95 Inactive DFGin ABAminus out-out out-out YB4 TOE Type1 Allosteric 519 - 795 None None 1
5AP5A 2.8 Inactive DFGin ABAminus out-out none-out 7RO 1KA Type1 Type1 519 - 794 S611G None 16
6TNDA 2.58 Inactive DFGin ABAminus in-in out-none 8RH Type1.5_Back 516 - 793 None None 12
3W1FA 2.7 Inactive DFGin ABAminus in-in out-out 1O5 Type1.5_Back 516 - 795 None None 10
3WZJA 2.75 Inactive DFGin ABAminus in-in out-out O43 Type1.5_Back 516 - 794 None None 10
3WZKA 2.3 Inactive DFGin ABAminus in-in out-out O23 Type1.5_Back 516 - 794 None None 10
5NADA 2.8 Inactive DFGin ABAminus in-in out-none 8RH Type1.5_Back 519 - 794 None X686 11
6TNBA 2.65 Inactive DFGin ABAminus out-out out-out 8QW Type1.5_Front 517 - 794 None X686 15
5N9SA 2.3 Inactive DFGin ABAminus out-out out-out 8QW Type1.5_Front 519 - 794 None X686 7
AF-P33981-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 517 - 799 None None 0
3H9FA 2.6 Inactive DFGin BLAplus in-none out-out 92M Type1 519 - 794 None X675,X676,X677 7
7CHMA 2.65 Inactive DFGin None in-in out-out FZF Type1 516 - 794 None X675,X686 8

TTK (Dual specificity protein kinase TTK)

Group: OTHER
Total number of chains: 77
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P33981-K1A
DFGin BLAplus 1 3H9FA
DFGin ABAminus 74 5AP1A
DFGin None 1 7CHMA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TTK_HUMAN 3CEKA 2.3 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 519 - 794 None None 14
Homo sapiens TTK_HUMAN 3DBQA 2.7 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 515 - 796 None None 12
Homo sapiens TTK_HUMAN 2ZMCA 3.14 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 516 - 794 None None 9
Homo sapiens TTK_HUMAN 6GVJA 2.41 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 515 - 795 None None 0
Homo sapiens TTK_HUMAN 5NTTA 2.75 Inactive DFGin ABAminus out-out out-out SVE Type1 519 - 797 C604Y X686 0
Homo sapiens TTK_HUMAN 5LJJA 3.0 Inactive DFGin ABAminus out-out out-out AD5 Type1 519 - 795 C604Y None 5
Homo sapiens TTK_HUMAN 5MRBA 2.2 Inactive DFGin ABAminus out-out out-out C5N Type1 519 - 795 C604Y None 5
Homo sapiens TTK_HUMAN 5EH0A 2.18 Inactive DFGin ABAminus out-out out-out 5NW Type1 516 - 794 None None 10
Homo sapiens TTK_HUMAN 6H3KA 2.48 Inactive DFGin ABAminus out-out out-none FMW Type1 519 - 794 None None 12
Homo sapiens TTK_HUMAN 4JS8A 1.94 Inactive DFGin ABAminus in-out out-out 1PF Type1 515 - 793 None X675,X686 8
Homo sapiens TTK_HUMAN 4JT3A 2.2 Inactive DFGin ABAminus out-out out-out 1PH Type1 515 - 794 None None 13
Homo sapiens TTK_HUMAN 4O6LA 2.38 Inactive DFGin ABAminus out-out out-none 2QK Type1 515 - 793 None X675,X676,X677 8
Homo sapiens TTK_HUMAN 4O6LB 2.38 Inactive DFGin ABAminus out-out out-out 2QK Type1 515 - 793 None X675,X676,X677 11
Homo sapiens TTK_HUMAN 4ZEGA 2.33 Inactive DFGin ABAminus in-in out-none 052 Type1 516 - 795 None None 11
Homo sapiens TTK_HUMAN 7CILA 2.3 Inactive DFGin ABAminus in-in out-out FZR Type1 515 - 795 None X686 9
Homo sapiens TTK_HUMAN 7CHNA 2.4 Inactive DFGin ABAminus in-out out-out FZL Type1 515 - 795 None X675,X676,X677,X686 4
Homo sapiens TTK_HUMAN 7CHTA 2.4 Inactive DFGin ABAminus in-in out-none FZO Type1 515 - 794 None X675,X676,X677,X686 7
Homo sapiens TTK_HUMAN 7CJAA 2.49 Inactive DFGin ABAminus in-in out-out G0U Type1 515 - 795 None X675,X676,X677,X686 8
Homo sapiens TTK_HUMAN 7CLHA 2.9 Inactive DFGin ABAminus out-out out-out G5C Type1 516 - 795 None X675,X676,X677,X686 9
Homo sapiens TTK_HUMAN 4D2SA 2.5 Inactive DFGin ABAminus out-out none-none DYK Type1 513 - 793 None None 17
Homo sapiens TTK_HUMAN 6TN9A 2.6 Inactive DFGin ABAminus in-out out-out NN5 Type1 515 - 794 None None 14
Homo sapiens TTK_HUMAN 6TNCA 2.3 Inactive DFGin ABAminus in-in out-out O23 Type1 516 - 794 None X686 10
Homo sapiens TTK_HUMAN 6N6OA 2.6 Inactive DFGin ABAminus out-out out-none KE7 Type1 515 - 794 None None 16
Homo sapiens TTK_HUMAN 3GFWA 2.74 Inactive DFGin ABAminus out-out none-out S22 Type1 519 - 794 None None 16
Homo sapiens TTK_HUMAN 4BHZA 2.85 Inactive DFGin ABAminus out-out out-out Z0B Type1 519 - 794 None None 12
Homo sapiens TTK_HUMAN 4BI0A 2.84 Inactive DFGin ABAminus out-out out-out Z0W Type1 519 - 794 None None 12
Homo sapiens TTK_HUMAN 4BI1A 2.7 Inactive DFGin ABAminus out-out out-out ZO6 Type1 519 - 794 None None 13
Homo sapiens TTK_HUMAN 4BI2A 3.11 Inactive DFGin ABAminus out-out out-out ZO8 Type1 519 - 794 None None 13
Homo sapiens TTK_HUMAN 4C4EA 2.6 Inactive DFGin ABAminus out-out out-out 4T9 Type1 519 - 794 None X686 9
Homo sapiens TTK_HUMAN 4C4FA 2.36 Inactive DFGin ABAminus out-out out-out 7CE Type1 519 - 794 None X686 12
Homo sapiens TTK_HUMAN 4C4GA 2.65 Inactive DFGin ABAminus out-out none-out 7RO Type1 519 - 794 None X686 15
Homo sapiens TTK_HUMAN 4C4HA 2.8 Inactive DFGin ABAminus out-out none-none 7RO Type1 519 - 794 None None 17
Homo sapiens TTK_HUMAN 4C4IA 2.65 Inactive DFGin ABAminus out-out out-none X20 Type1 519 - 794 None None 14
Homo sapiens TTK_HUMAN 4C4JA 2.5 Inactive DFGin ABAminus in-in out-out X21 Type1 519 - 794 None X686 8
Homo sapiens TTK_HUMAN 4CV8A 3.0 Inactive DFGin ABAminus out-none out-out 3D7 Type1 519 - 794 None None 13
Homo sapiens TTK_HUMAN 4CV9A 2.5 Inactive DFGin ABAminus out-out out-out W2K Type1 519 - 794 None X686 14
Homo sapiens TTK_HUMAN 4CVAA 2.5 Inactive DFGin ABAminus out-out out-out WBI Type1 519 - 794 None X686 14
Homo sapiens TTK_HUMAN 5AP0A 2.15 Inactive DFGin ABAminus out-out out-out AU5 Type1 519 - 795 None X686 13
Homo sapiens TTK_HUMAN 5AP1A 2.05 Inactive DFGin ABAminus in-out out-out O38 Type1 519 - 795 None X675,X676,X677,X686 2
Homo sapiens TTK_HUMAN 5AP2A 2.8 Inactive DFGin ABAminus in-in out-out PWU Type1 519 - 794 None None 10
Homo sapiens TTK_HUMAN 5EHLA 2.66 Inactive DFGin ABAminus out-none out-out 0SQ Type1 519 - 796 None None 14
Homo sapiens TTK_HUMAN 5EHOA 2.18 Inactive DFGin ABAminus out-out out-out 5O1 Type1 519 - 794 None None 9
Homo sapiens TTK_HUMAN 5EHYA 2.26 Inactive DFGin ABAminus out-out out-out 5O4 Type1 519 - 794 None None 13
Homo sapiens TTK_HUMAN 5EI2A 2.67 Inactive DFGin ABAminus out-out out-out 5O7 Type1 516 - 794 None None 12
Homo sapiens TTK_HUMAN 5EI6A 2.01 Inactive DFGin ABAminus in-out out-out 5OQ Type1 519 - 794 None None 5
Homo sapiens TTK_HUMAN 5EI8A 2.17 Inactive DFGin ABAminus out-out out-out 5OE Type1 519 - 753 None None 9
Homo sapiens TTK_HUMAN 5N87A 2.29 Inactive DFGin ABAminus out-out out-out N66 Type1 519 - 794 None X686 12
Homo sapiens TTK_HUMAN 5AP6A 2.1 Inactive DFGin ABAminus in-in out-out PWU Type1 519 - 794 C604W None 6
Homo sapiens TTK_HUMAN 5AP7A 2.45 Inactive DFGin ABAminus out-out out-out SVE Type1 519 - 794 C604W None 10
Homo sapiens TTK_HUMAN 5O91A 3.2 Inactive DFGin ABAminus out-out out-out C5N Type1 519 - 796 C604W None 6
Homo sapiens TTK_HUMAN 6B4WA 2.9 Inactive DFGin ABAminus in-none out-out CQ7 Type1 515 - 793 None None 9
Homo sapiens TTK_HUMAN 2X9EA 3.1 Inactive DFGin ABAminus out-out out-out SVE Type1 515 - 795 None None 15
Homo sapiens TTK_HUMAN 3VQUA 2.4 Inactive DFGin ABAminus out-out out-out O22 Type1 516 - 795 None None 10
Homo sapiens TTK_HUMAN 3WYXA 2.9 Inactive DFGin ABAminus in-out out-out O38 Type1 516 - 795 None None 11
Homo sapiens TTK_HUMAN 3WYYA 3.05 Inactive DFGin ABAminus in-out out-out O17 Type1 516 - 795 None None 11
Homo sapiens TTK_HUMAN 5N7VA 2.52 Inactive DFGin ABAminus out-out out-out 8PT Type1 519 - 794 None X686 7
Homo sapiens TTK_HUMAN 5N84A 2.3 Inactive DFGin ABAminus out-out out-out 8Q5 Type1 519 - 794 None None 12
Homo sapiens TTK_HUMAN 5N93A 2.1 Inactive DFGin ABAminus out-out out-out 8QE Type1 519 - 794 None X686 9
Homo sapiens TTK_HUMAN 5NA0A 2.9 Inactive DFGin ABAminus out-out out-out 8QZ Type1 519 - 794 None X686 12
Homo sapiens TTK_HUMAN 3HMNA 2.7 Inactive DFGin ABAminus out-out out-out ATP Type1 516 - 794 None None 12
Homo sapiens TTK_HUMAN 3HMOA 2.4 Inactive DFGin ABAminus out-out out-out STU Type1 514 - 794 None None 12
Homo sapiens TTK_HUMAN 3HMPA 2.3 Inactive DFGin ABAminus out-out out-out CX4 Type1 516 - 794 None None 10
Homo sapiens TTK_HUMAN 5AP3A 2.7 Inactive DFGin ABAminus out-out out-out AU5 Type1 519 - 794 S611G X686 12
Homo sapiens TTK_HUMAN 5AP4A 2.85 Inactive DFGin ABAminus out-out out-out O38 Type1 519 - 794 S611G X686 9
Homo sapiens TTK_HUMAN 2ZMDA 2.88 Inactive DFGin ABAminus out-out out-out 537 Type1 516 - 795 T686A None 9
Homo sapiens TTK_HUMAN 7LQDA 1.95 Inactive DFGin ABAminus out-out out-out YB4 TOE Type1 Allosteric 519 - 795 None None 1
Homo sapiens TTK_HUMAN 5AP5A 2.8 Inactive DFGin ABAminus out-out none-out 7RO 1KA Type1 Type1 519 - 794 S611G None 16
Homo sapiens TTK_HUMAN 6TNDA 2.58 Inactive DFGin ABAminus in-in out-none 8RH Type1.5_Back 516 - 793 None None 12
Homo sapiens TTK_HUMAN 3W1FA 2.7 Inactive DFGin ABAminus in-in out-out 1O5 Type1.5_Back 516 - 795 None None 10
Homo sapiens TTK_HUMAN 3WZJA 2.75 Inactive DFGin ABAminus in-in out-out O43 Type1.5_Back 516 - 794 None None 10
Homo sapiens TTK_HUMAN 3WZKA 2.3 Inactive DFGin ABAminus in-in out-out O23 Type1.5_Back 516 - 794 None None 10
Homo sapiens TTK_HUMAN 5NADA 2.8 Inactive DFGin ABAminus in-in out-none 8RH Type1.5_Back 519 - 794 None X686 11
Homo sapiens TTK_HUMAN 6TNBA 2.65 Inactive DFGin ABAminus out-out out-out 8QW Type1.5_Front 517 - 794 None X686 15
Homo sapiens TTK_HUMAN 5N9SA 2.3 Inactive DFGin ABAminus out-out out-out 8QW Type1.5_Front 519 - 794 None X686 7
Homo sapiens TTK_HUMAN AF-P33981-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 517 - 799 None None 0
Homo sapiens TTK_HUMAN 3H9FA 2.6 Inactive DFGin BLAplus in-none out-out 92M Type1 519 - 794 None X675,X676,X677 7
Homo sapiens TTK_HUMAN 7CHMA 2.65 Inactive DFGin None in-in out-out FZF Type1 516 - 794 None X675,X686 8

TTK (Dual specificity protein kinase TTK)

No non-human structures known.