OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 78
Active chains: 1
Uniprot: TTK_HUMAN
Kinase Domain Residues: 525 - 791
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 74 94.9% 5AP1A
DFGin BLAminus 2 2.6% AF-P33981-K3A
DFGin BLAplus 1 1.3% 3H9FA
DFGin None 1 1.3% 7CHMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P33981-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 517 - 799 0 None None Dual specificity protein kinase TTK
3HMNA 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ATP ATPlike 516 - 794 0 None None Dual specificity protein kinase TTK
3CEKA 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 519 - 794 0 None None Dual specificity protein kinase TTK
3DBQA 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 515 - 796 0 None None Dual specificity protein kinase TTK
2ZMCA 3.14 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 516 - 794 0 None None Dual specificity protein kinase TTK
6GVJA 2.41 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 515 - 795 0 None None Dual specificity protein kinase TTK
5NTTA 2.75 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_oooo SVE Type1 519 - 797 0 TPO686 C604Y Dual specificity protein kinase TTK
5LJJA 3.0 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo AD5 Type1 519 - 795 0 None C604Y Dual specificity protein kinase TTK
5MRBA 2.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo C5N Type1 519 - 795 0 None C604Y Dual specificity protein kinase TTK
5EH0A 2.18 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 5NW Type1 516 - 794 0 None None Dual specificity protein kinase TTK
6H3KA 2.48 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn FMW Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4JS8A 1.94 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaini APEdist_nnoo 1PF Type1 515 - 793 0 TPO675,TPO686 None Dual specificity protein kinase TTK
4JT3A 2.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno 1PH Type1 515 - 794 0 None None Dual specificity protein kinase TTK
4O6LA 2.38 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 2QK Type1 515 - 793 0 TPO675,TPO676,SEP677 None Dual specificity protein kinase TTK
4O6LB 2.38 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno 2QK Type1 515 - 793 0 TPO675,TPO676,SEP677 None Dual specificity protein kinase TTK
4ZEGA 2.33 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 052 Type1 516 - 795 0 None None Dual specificity protein kinase TTK
7CILA 2.3 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaini APEdist_nnoo FZR Type1 515 - 795 0 TPO686 None Dual specificity protein kinase TTK
7CHNA 2.4 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaini APEdist_nnoo FZL Type1 515 - 795 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK
7CHTA 2.4 Inactive DFGin‑ABAminus in-in out-none nonTYR APEdihe_aanni APEdist_nnnn FZO Type1 515 - 794 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK
7CJAA 2.49 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaoni APEdist_nnoo G0U Type1 515 - 795 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK
7CLHA 2.9 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnoo G5C Type1 516 - 795 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK
4D2SA 2.5 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn DYK Type1 513 - 793 0 None None Dual specificity protein kinase TTK
6TN9A 2.6 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnoo NN5 Type1 515 - 794 0 None None Dual specificity protein kinase TTK
6TNCA 2.3 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaini APEdist_nnoo O23 Type1 516 - 794 0 TPO686 None Dual specificity protein kinase TTK
6N6OA 2.6 Inactive DFGin‑ABAminus out-out out-none nonTYR APEdihe_aanni APEdist_nnnn KE7 Type1 515 - 794 0 None None Dual specificity protein kinase TTK
3GFWA 2.74 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaoni APEdist_nnno S22 Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4BHZA 2.85 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo Z0B Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4BI0A 2.84 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo Z0W Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4BI1A 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo ZO6 Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4BI2A 3.11 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo ZO8 Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4C4EA 2.6 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo 4T9 Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
4C4FA 2.36 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo 7CE Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
4C4GA 2.65 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaono APEdist_nnoo 7RO Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
4C4HA 2.8 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 7RO Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4C4IA 2.65 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn X20 Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4C4JA 2.5 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaini APEdist_nnoo X21 Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
4CV8A 3.0 Inactive DFGin‑ABAminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno 3D7 Type1 519 - 794 0 None None Dual specificity protein kinase TTK
4CV9A 2.5 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnoo W2K Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
4CVAA 2.5 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnoo WBI Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
5AP0A 2.15 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo AU5 Type1 519 - 795 0 TPO686 None Dual specificity protein kinase TTK
5AP1A 2.05 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaini APEdist_nnoo O38 Type1 519 - 795 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK
5AP2A 2.8 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno PWU Type1 519 - 794 0 None None Dual specificity protein kinase TTK
5EHLA 2.66 Inactive DFGin‑ABAminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnoo 0SQ Type1 519 - 796 0 None None Dual specificity protein kinase TTK
5EHOA 2.18 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5O1 Type1 519 - 794 0 None None Dual specificity protein kinase TTK
5EHYA 2.26 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5O4 Type1 519 - 794 0 None None Dual specificity protein kinase TTK
5EI2A 2.67 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 5O7 Type1 516 - 794 0 None None Dual specificity protein kinase TTK
5EI6A 2.01 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 5OQ Type1 519 - 794 0 None None Dual specificity protein kinase TTK
5EI8A 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5OE Type1 519 - 753 0 None None Dual specificity protein kinase TTK
5N87A 2.29 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo N66 Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
5AP6A 2.1 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo PWU Type1 519 - 794 0 None C604W Dual specificity protein kinase TTK
5AP7A 2.45 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo SVE Type1 519 - 794 0 None C604W Dual specificity protein kinase TTK
5O91A 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo C5N Type1 519 - 796 0 None C604W Dual specificity protein kinase TTK
6B4WA 2.9 Inactive DFGin‑ABAminus in-none out-out nonTYR APEdihe_aaioi APEdist_nnoo CQ7 Type1 515 - 793 0 None None Dual specificity protein kinase TTK
2X9EA 3.1 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno SVE Type1 515 - 795 0 None None Dual specificity protein kinase TTK
3VQUA 2.4 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno O22 Type1 516 - 795 0 None None Dual specificity protein kinase TTK
3WYXA 2.9 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno O38 Type1 516 - 795 0 None None Dual specificity protein kinase TTK
3WYYA 3.05 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno O17 Type1 516 - 795 0 None None Dual specificity protein kinase TTK
5N7VA 2.52 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaono APEdist_oooo 8PT Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
5N84A 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo 8Q5 Type1 519 - 794 0 None None Dual specificity protein kinase TTK
5N93A 2.1 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnoo 8QE Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
5NA0A 2.9 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoni APEdist_nnoo 8QZ Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
3HMOA 2.4 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo STU Type1 514 - 794 0 None None Dual specificity protein kinase TTK
3HMPA 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo CX4 Type1 516 - 794 0 None None Dual specificity protein kinase TTK
5AP3A 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_iooo AU5 Type1 519 - 794 0 TPO686 S611G Dual specificity protein kinase TTK
5AP4A 2.85 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo O38 Type1 519 - 794 0 TPO686 S611G Dual specificity protein kinase TTK
2ZMDA 2.88 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoni APEdist_oooo 537 Type1 516 - 795 0 None T686A Dual specificity protein kinase TTK
7LQDA 1.95 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YB4, TOE Type1, Allosteric 519 - 795 0 None None Dual specificity protein kinase TTK
5AP5A 2.8 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 7RO, 1KA Type1, Type1 519 - 794 0 None S611G Dual specificity protein kinase TTK
6TNDA 2.58 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 8RH Type1.5_Back 516 - 793 0 None None Dual specificity protein kinase TTK
3W1FA 2.7 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno 1O5 Type1.5_Back 516 - 795 0 None None Dual specificity protein kinase TTK
3WZJA 2.75 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno O43 Type1.5_Back 516 - 794 0 None None Dual specificity protein kinase TTK
3WZKA 2.3 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno O23 Type1.5_Back 516 - 794 0 None None Dual specificity protein kinase TTK
5NADA 2.8 Inactive DFGin‑ABAminus in-in out-none nonTYR APEdihe_aanni APEdist_nnnn 8RH Type1.5_Back 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
6TNBA 2.65 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnno 8QW Type1.5_Front 517 - 794 0 TPO686 None Dual specificity protein kinase TTK
5N9SA 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_oooo 8QW Type1.5_Front 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
AF-P33981-K1A -1.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 517 - 799 0 None None Dual specificity protein kinase TTK
3H9FA 2.6 Inactive DFGin‑BLAplus in-none out-out nonTYR APEdihe_aaoni APEdist_nnno 92M Type1 519 - 794 0 TPO675,TPO676,SEP677 None Dual specificity protein kinase TTK
7CHMA 2.65 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoni APEdist_nnoo FZF Type1 516 - 794 0 TPO675,TPO686 None Dual specificity protein kinase TTK

OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 78
Active chains: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 74 94.9% 5AP1A
DFGin BLAminus 2 2.6% AF-P33981-K3A
DFGin BLAplus 1 1.3% 3H9FA
DFGin None 1 1.3% 7CHMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TTK_HUMAN AF-P33981-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 517 - 799 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3HMNA 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ATP ATPlike 516 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3CEKA 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3DBQA 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 515 - 796 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 2ZMCA 3.14 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 516 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 6GVJA 2.41 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 515 - 795 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5NTTA 2.75 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_oooo SVE Type1 519 - 797 0 TPO686 C604Y Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5LJJA 3.0 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo AD5 Type1 519 - 795 0 None C604Y Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5MRBA 2.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo C5N Type1 519 - 795 0 None C604Y Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5EH0A 2.18 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 5NW Type1 516 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 6H3KA 2.48 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn FMW Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4JS8A 1.94 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaini APEdist_nnoo 1PF Type1 515 - 793 0 TPO675,TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4JT3A 2.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno 1PH Type1 515 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4O6LA 2.38 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 2QK Type1 515 - 793 0 TPO675,TPO676,SEP677 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4O6LB 2.38 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno 2QK Type1 515 - 793 0 TPO675,TPO676,SEP677 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4ZEGA 2.33 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 052 Type1 516 - 795 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 7CILA 2.3 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaini APEdist_nnoo FZR Type1 515 - 795 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 7CHNA 2.4 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaini APEdist_nnoo FZL Type1 515 - 795 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 7CHTA 2.4 Inactive DFGin‑ABAminus in-in out-none nonTYR APEdihe_aanni APEdist_nnnn FZO Type1 515 - 794 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 7CJAA 2.49 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaoni APEdist_nnoo G0U Type1 515 - 795 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 7CLHA 2.9 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnoo G5C Type1 516 - 795 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4D2SA 2.5 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn DYK Type1 513 - 793 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 6TN9A 2.6 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnoo NN5 Type1 515 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 6TNCA 2.3 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaini APEdist_nnoo O23 Type1 516 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 6N6OA 2.6 Inactive DFGin‑ABAminus out-out out-none nonTYR APEdihe_aanni APEdist_nnnn KE7 Type1 515 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3GFWA 2.74 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaoni APEdist_nnno S22 Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4BHZA 2.85 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo Z0B Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4BI0A 2.84 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo Z0W Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4BI1A 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo ZO6 Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4BI2A 3.11 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo ZO8 Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4C4EA 2.6 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo 4T9 Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4C4FA 2.36 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo 7CE Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4C4GA 2.65 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaono APEdist_nnoo 7RO Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4C4HA 2.8 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 7RO Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4C4IA 2.65 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn X20 Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4C4JA 2.5 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaini APEdist_nnoo X21 Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4CV8A 3.0 Inactive DFGin‑ABAminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno 3D7 Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4CV9A 2.5 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnoo W2K Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 4CVAA 2.5 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnoo WBI Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5AP0A 2.15 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo AU5 Type1 519 - 795 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5AP1A 2.05 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaini APEdist_nnoo O38 Type1 519 - 795 0 TPO675,TPO676,SEP677,TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5AP2A 2.8 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno PWU Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5EHLA 2.66 Inactive DFGin‑ABAminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnoo 0SQ Type1 519 - 796 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5EHOA 2.18 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5O1 Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5EHYA 2.26 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5O4 Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5EI2A 2.67 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 5O7 Type1 516 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5EI6A 2.01 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo 5OQ Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5EI8A 2.17 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5OE Type1 519 - 753 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5N87A 2.29 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo N66 Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5AP6A 2.1 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo PWU Type1 519 - 794 0 None C604W Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5AP7A 2.45 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo SVE Type1 519 - 794 0 None C604W Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5O91A 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo C5N Type1 519 - 796 0 None C604W Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 6B4WA 2.9 Inactive DFGin‑ABAminus in-none out-out nonTYR APEdihe_aaioi APEdist_nnoo CQ7 Type1 515 - 793 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 2X9EA 3.1 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno SVE Type1 515 - 795 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3VQUA 2.4 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno O22 Type1 516 - 795 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3WYXA 2.9 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno O38 Type1 516 - 795 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3WYYA 3.05 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno O17 Type1 516 - 795 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5N7VA 2.52 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaono APEdist_oooo 8PT Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5N84A 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nooo 8Q5 Type1 519 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5N93A 2.1 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnoo 8QE Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5NA0A 2.9 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoni APEdist_nnoo 8QZ Type1 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3HMOA 2.4 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo STU Type1 514 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3HMPA 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo CX4 Type1 516 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5AP3A 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_iooo AU5 Type1 519 - 794 0 TPO686 S611G Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5AP4A 2.85 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nooo O38 Type1 519 - 794 0 TPO686 S611G Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 2ZMDA 2.88 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoni APEdist_oooo 537 Type1 516 - 795 0 None T686A Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 7LQDA 1.95 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YB4, TOE Type1, Allosteric 519 - 795 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5AP5A 2.8 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 7RO, 1KA Type1, Type1 519 - 794 0 None S611G Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 6TNDA 2.58 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 8RH Type1.5_Back 516 - 793 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3W1FA 2.7 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno 1O5 Type1.5_Back 516 - 795 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3WZJA 2.75 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno O43 Type1.5_Back 516 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3WZKA 2.3 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno O23 Type1.5_Back 516 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5NADA 2.8 Inactive DFGin‑ABAminus in-in out-none nonTYR APEdihe_aanni APEdist_nnnn 8RH Type1.5_Back 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 6TNBA 2.65 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnno 8QW Type1.5_Front 517 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 5N9SA 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_oooo 8QW Type1.5_Front 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN AF-P33981-K1A -1.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 517 - 799 0 None None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 3H9FA 2.6 Inactive DFGin‑BLAplus in-none out-out nonTYR APEdihe_aaoni APEdist_nnno 92M Type1 519 - 794 0 TPO675,TPO676,SEP677 None Dual specificity protein kinase TTK Homo sapiens
TTK_HUMAN 7CHMA 2.65 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoni APEdist_nnoo FZF Type1 516 - 794 0 TPO675,TPO686 None Dual specificity protein kinase TTK Homo sapiens

OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism