CAMK_PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Total number of chains: 14
Active chains: 2
Uniprot: AAPK1_HUMAN
Kinase Domain Residues: 27 - 279
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 35.7% AF-Q13131-K3A
DFGin None 5 35.7% 7JHGA
DFGin ABAminus 2 14.3% 6C9FA
DFGinter None 2 14.3% 4REDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
6C9JA 3.05 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii R34, STU Allosteric, Type1 22 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1
AF-Q13131-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 287 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
6C9FA 2.924 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R34, STU Allosteric, Type1 22 - 558 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1
7JIJA 5.5 Inactive DFGin‑ABAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1
6C9GA 2.7 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R93, STU Allosteric, Type1 22 - 558 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1
6C9HA 2.65 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R34, STU Allosteric, Type1 22 - 558 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
AF-Q13131-K1A -1.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 19 - 287 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
7JHHA 3.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
7JHGA 3.47 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo TAK Type1 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
7M74A 3.93 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo TAK Type1 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
4RERA 4.047 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1
4REWA 4.58 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iiio STU Type1 20 - 559 0 None E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1
4REDA 2.95 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 22 - 360 0 None K52A 5'-AMP-activated protein kinase catalytic subunit alpha-1
4REDB 2.95 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 22 - 360 0 None K52A 5'-AMP-activated protein kinase catalytic subunit alpha-1

CAMK_PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Total number of chains: 24
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 8 33.3% 6C9FA
DFGin BLAminus 7 29.2% AF-Q13131-K3A
DFGin None 7 29.2% 4CFHA
DFGinter None 2 8.3% 4REDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AAPK1_HUMAN 6C9JA 3.05 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii R34, STU Allosteric, Type1 22 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN AF-Q13131-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 287 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 6C9FA 2.924 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R34, STU Allosteric, Type1 22 - 558 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 7JIJA 5.5 Inactive DFGin‑ABAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 6C9GA 2.7 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R93, STU Allosteric, Type1 22 - 558 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 6C9HA 2.65 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R34, STU Allosteric, Type1 22 - 558 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN AF-Q13131-K1A -1.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 19 - 287 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 7JHHA 3.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 7JHGA 3.47 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo TAK Type1 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 7M74A 3.93 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo TAK Type1 22 - 559 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 4RERA 4.047 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 4REWA 4.58 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iiio STU Type1 20 - 559 0 None E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 4REDA 2.95 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 22 - 360 0 None K52A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_HUMAN 4REDB 2.95 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 22 - 360 0 None K52A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
AAPK1_MOUSE 5UFUA 3.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 85V Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus
AAPK1_RAT 6E4TA 3.4 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiio HTV, STU Allosteric, Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 4QFGA 3.46 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 4QFRA 3.34 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 32J Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 4QFSA 3.55 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 32H Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 6E4UA 3.27 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, HU7 Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 6E4WA 3.35 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, HUG Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 5T5TA 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 4CFHA 3.24 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiio APEdist_iiio STU Type1 21 - 481 0 TPO183,TPO388 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 5KQ5A 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 6VT Type1, Allosteric 21 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus

CAMK_PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Total number of chains: 10
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 6 60.0% 6E4UA
DFGin BLAminus 2 20.0% 5UFUA
DFGin None 2 20.0% 4CFHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AAPK1_MOUSE 5UFUA 3.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 85V Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus
AAPK1_RAT 6E4TA 3.4 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiio HTV, STU Allosteric, Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 4QFGA 3.46 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 4QFRA 3.34 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 32J Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 4QFSA 3.55 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 32H Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 6E4UA 3.27 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, HU7 Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 6E4WA 3.35 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, HUG Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 5T5TA 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 4CFHA 3.24 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiio APEdist_iiio STU Type1 21 - 481 0 TPO183,TPO388 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
AAPK1_RAT 5KQ5A 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 6VT Type1, Allosteric 21 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus