TKL_ACVR1 (Activin receptor type-1)

Total number of chains: 163
Active chains: 2
Uniprot: ACVR1_HUMAN
Kinase Domain Residues: 208 - 497
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 156 95.7% AF-Q04771-K1A
DFGin ABAminus 6 3.7% 6T6DB
DFGin None 1 0.6% 6T6DA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q04771-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 200 - 505 0 None None Activin receptor type-1
AF-Q04771-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 200 - 505 0 None None Activin receptor type-1
6T6DB 2.56 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi MM8 Type1 203 - 499 0 None Q207D Activin receptor type-1
6T6DC 2.56 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 205 - 498 0 None Q207D Activin receptor type-1
6ZGCA 2.67 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii H8H Type1 205 - 499 0 None Q207D Activin receptor type-1
6ZGCB 2.67 Inactive DFGin‑ABAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii H8H Type1 203 - 499 0 None Q207D Activin receptor type-1
6ZGCC 2.67 Inactive DFGin‑ABAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi H8H Type1 201 - 498 0 None Q207D Activin receptor type-1
6ZGCD 2.67 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii H8H Type1 203 - 498 0 None Q207D Activin receptor type-1
6UNQA 2.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 206 - 496 0 None K493A Activin receptor type-1
6UNRA 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 208 - 496 0 None None Activin receptor type-1
6SZMA 1.42 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi M2Z, M2Z, M2Z Allosteric, Allosteric, Type1 202 - 499 0 None None Activin receptor type-1
5S7QB 1.53 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi XJM, LU8, XJM Allosteric, Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
6JUXA 1.75 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi C9U Type1 203 - 499 0 None R206H Activin receptor type-1
4DYMA 2.42 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IYZ Type1 207 - 499 0 None R206H Activin receptor type-1
6ACRA 2.01 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 9TO Type1 203 - 498 0 None R206H Activin receptor type-1
6ACRB 2.01 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 9TO Type1 203 - 498 0 None R206H Activin receptor type-1
7C3GA 1.802 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi FH0 Type1 203 - 499 0 None R206H Activin receptor type-1
7C3GB 1.802 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi FH0 Type1 204 - 499 0 None R206H Activin receptor type-1
9L04A 2.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A1L4C Type1 203 - 499 0 None R206H Activin receptor type-1
3MTFA 2.15 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 203 - 498 0 None Q207D Activin receptor type-1
3MTFB 2.15 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 202 - 499 0 None Q207D Activin receptor type-1
3OOMA 2.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 507 Type1 203 - 499 0 None Q207D Activin receptor type-1
3Q4UA 1.82 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 202 - 499 0 None Q207D Activin receptor type-1
3Q4UB 1.82 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 201 - 498 0 None Q207D Activin receptor type-1
3Q4UC 1.82 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 204 - 499 0 None Q207D Activin receptor type-1
3Q4UD 1.82 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 201 - 499 0 None Q207D Activin receptor type-1
4BGGA 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 844 Type1 203 - 498 0 None Q207D Activin receptor type-1
4BGGB 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 844 Type1 203 - 498 0 None Q207D Activin receptor type-1
4BGGC 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 844 Type1 204 - 497 0 None Q207D Activin receptor type-1
4BGGD 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 844 Type1 204 - 498 0 None Q207D Activin receptor type-1
5OXGA 2.13 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4B Type1 203 - 498 0 None Q207D Activin receptor type-1
5OXGB 2.13 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4B Type1 203 - 498 0 None Q207D Activin receptor type-1
5OXGC 2.13 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4B Type1 201 - 499 0 None Q207D Activin receptor type-1
5OXGD 2.13 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4B Type1 204 - 499 0 None Q207D Activin receptor type-1
5OY6A 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4E Type1 204 - 498 0 None Q207D Activin receptor type-1
5OY6B 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4E Type1 203 - 498 0 None Q207D Activin receptor type-1
5OY6C 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4E Type1 204 - 498 0 None Q207D Activin receptor type-1
5OY6D 2.56 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi B4E Type1 204 - 499 0 None Q207D Activin receptor type-1
5S77B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
5S78B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 499 0 None Q207D Activin receptor type-1
5S79B 1.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 498 0 None Q207D Activin receptor type-1
5S7GB 1.78 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8 Type1 207 - 499 0 None Q207D Activin receptor type-1
5S7HB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
5S7JB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 206 - 499 0 None Q207D Activin receptor type-1
5S7PB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 499 0 None Q207D Activin receptor type-1
5S7WB 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
5S83B 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
5S84B 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 206 - 499 0 None Q207D Activin receptor type-1
5S89B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
6GI6A 1.98 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi EZB Type1 202 - 499 0 None Q207D Activin receptor type-1
6GINA 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IR2 Type1 204 - 499 0 None Q207D Activin receptor type-1
6GINB 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IR2 Type1 204 - 499 0 None Q207D Activin receptor type-1
6GIPA 2.17 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi EUN Type1 204 - 499 0 None Q207D Activin receptor type-1
6SRHA 1.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 201 - 499 0 None Q207D Activin receptor type-1
6SZMB 1.42 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi M2Z Type1 205 - 499 0 None None Activin receptor type-1
6T6DD 2.56 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii MM8 Type1 203 - 498 0 None Q207D Activin receptor type-1
6T8NA 1.77 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi MVE Type1 203 - 498 0 None Q207D Activin receptor type-1
6T8NB 1.77 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi MVE Type1 203 - 499 0 None Q207D Activin receptor type-1
6TN8A 1.63 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 5U6 Type1 204 - 499 0 None None Activin receptor type-1
6Z36B 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi Q5Z Type1 204 - 498 0 None Q207D Activin receptor type-1
7A21A 2.14 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi QWQ Type1 203 - 498 0 None Q207D Activin receptor type-1
7A21B 2.14 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi QWQ Type1 203 - 498 0 None Q207D Activin receptor type-1
7NNSB 2.14 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi C87 Type1 204 - 499 0 None Q207D Activin receptor type-1
8C7WA 2.26 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi U0C Type1 202 - 499 0 None Q207D Activin receptor type-1
8C7ZA 2.23 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi TZX Type1 204 - 498 0 None Q207D Activin receptor type-1
8R7GA 2.09 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi YEE Type1 205 - 499 0 None Q207D Activin receptor type-1
8R7GB 2.09 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi YEE Type1 205 - 498 0 None Q207D Activin receptor type-1
8R7GD 2.09 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi YEE Type1 204 - 498 0 None Q207D Activin receptor type-1
9D8FA 1.86 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A3C Type1 193 - 499 0 None None Activin receptor type-1
9D8FB 1.86 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A3C Type1 200 - 499 0 None None Activin receptor type-1
8UWRA 2.04 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi XQX Type1 203 - 499 0 None Q207D Activin receptor type-1
3H9RA 2.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi TAK Type1 172 - 499 0 None None Activin receptor type-1
4C02A 2.17 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii TAK Type1 178 - 499 0 None None Activin receptor type-1
6I1SA 1.52 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi E26 Type1 172 - 499 0 None None Activin receptor type-1
9D8EA 1.72 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A29 Type1 193 - 499 0 None None Activin receptor type-1
9D8EB 1.72 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A29 Type1 193 - 498 0 None None Activin receptor type-1
9RDAA 1.748 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi A1JFB Type1 172 - 498 0 None None Activin receptor type-1
9D8ZA 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A3D Type1 203 - 499 0 None None Activin receptor type-1
9D8ZB 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A3D Type1 193 - 499 0 None None Activin receptor type-1
6UNSA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 204 - 496 0 None K492A,K493A Activin receptor type-1
6UNSB 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 204 - 496 0 None K492A,K493A Activin receptor type-1
6EIXA 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 192 - 503 0 None Q207E Activin receptor type-1
5S7BB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH7 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7CB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, T5Y Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7DB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XHD Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7EB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XEA Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7KB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XEJ Type1, Allosteric 205 - 499 0 None None Activin receptor type-1
5S7MB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HVK Type1, Allosteric 208 - 499 0 None Q207D Activin receptor type-1
5S7NB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 2AI Type1, Allosteric 207 - 499 0 None Q207D Activin receptor type-1
5S7SB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 09V Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7VB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH1 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7XB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LGA Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7ZB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, BYZ Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S82B 1.71 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LU8, LAC Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S86B 1.31 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LU8, XK7 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S87B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKD Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S88B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKS Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S8AB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKY Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
8PODA 2.59 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 7IO, F Type1, Allosteric 172 - 498 0 None None Activin receptor type-1
5S75B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HUH, HUH Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S79A 1.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7AB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, T5V, T5V Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7EA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7FA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7FB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH4, XH4 Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7GA 1.78 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 498 0 None Q207D Activin receptor type-1
5S7OA 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S7QA 1.53 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7UA 1.59 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7UB 1.59 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioi LU8, XGY, XGY Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S7VA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7WA 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7YA 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S80A 1.67 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S80B 1.67 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGM, XGM Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S82A 1.71 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S87A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S88A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S9KA 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
6SRHB 1.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
6Z36A 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi Q5Z, Q5Z, Q5Z Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S77A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, BAQ Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7DA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XHD Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7JA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XHG Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S7KA 1.31 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8, XEJ Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None None Activin receptor type-1
5S7LA 1.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XHJ Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S7MA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, HVK, HVK Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7NA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, 2AI Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S7PA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, V1L Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7SA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, 09V Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7TB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGJ, XGJ, XGJ Type1, Allosteric, Allosteric, Allosteric 205 - 498 0 None Q207D Activin receptor type-1
5S7XA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, LGA Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S86A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK7 Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S89A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XKV Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S8AA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XKY Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S8BB 1.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XFV, XFV, XFV Type1, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S75A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HUH, HUH Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7AA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, T5V, T5V Type1, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S7BA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oioi LU8, LU8, LU8, XH7, XH7 Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7HA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HVB, HVB Type1, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S7ZA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, BYZ, BYZ Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S81B 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJV, XJV, XJV, XJV Type1, Allosteric, Allosteric, Allosteric, Allosteric 208 - 499 0 None Q207D Activin receptor type-1
5S7CA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, T5Y, T5Y, T5Y Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7IA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HV2, HV2, HV2 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S7TA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XGJ, XGJ, XGJ Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7YB 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJP, XJP, XJP, XJP, XJP Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 207 - 499 0 None Q207D Activin receptor type-1
5S7RB 1.46 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGS, XGS, XGS, XGS, XGS, XGS Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S85A 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK4, XK4, XK4, XK4 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S8BA 1.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XFV, XFV, XFV, XFV Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
5S7RA 1.46 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XGS, XGS, XGS, XGS, XGS Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
5S7IB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HV2, HV2, HV2, HV2, HV2, HV2, HV2, HV2, HV2 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
5S78A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XGV, XGV, XGV Type1, Allosteric, Allosteric, Allosteric, Allosteric, Type1 202 - 499 0 None Q207D Activin receptor type-1
5S81A 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XJV, XJV Type1, Allosteric, Allosteric, Allosteric, Type1 202 - 499 0 None Q207D Activin receptor type-1
5S76A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, 02A, 02A Type1, Allosteric, Allosteric, Allosteric, Type1.5_Back 202 - 499 0 None Q207D Activin receptor type-1
5S7LB 1.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XHJ, XHJ, XHJ, XHJ Type1, Allosteric, Allosteric, Allosteric, Type3 205 - 499 0 None Q207D Activin receptor type-1
5S84A 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK1 Type1, Allosteric, Allosteric, Type1 201 - 499 0 None Q207D Activin receptor type-1
5S83A 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XJY Type1, Allosteric, Allosteric, Type3 202 - 499 0 None Q207D Activin receptor type-1
5S7OB 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJJ Type1, Type1 205 - 499 0 None Q207D Activin receptor type-1
5S85B 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XK4, XK4, XK4 Type1, Type1, Allosteric, Allosteric 207 - 499 0 None Q207D Activin receptor type-1
5S76B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 02A Type1, Type1.5_Back 205 - 499 0 None Q207D Activin receptor type-1
5S9KB 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, YV4 Type1, Type3 205 - 499 0 None Q207D Activin receptor type-1
6T6DA 2.56 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 204 - 499 0 None Q207D Activin receptor type-1
8R7GC 2.09 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii YEE Type1 206 - 498 0 None Q207D Activin receptor type-1

TKL_ACVR1 (Activin receptor type-1)

Total number of chains: 163
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 156 95.7% AF-Q04771-K1A
DFGin ABAminus 6 3.7% 6T6DB
DFGin None 1 0.6% 6T6DA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ACVR1_HUMAN AF-Q04771-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 200 - 505 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN AF-Q04771-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 200 - 505 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6T6DB 2.56 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi MM8 Type1 203 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6T6DC 2.56 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 205 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6ZGCA 2.67 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii H8H Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6ZGCB 2.67 Inactive DFGin‑ABAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii H8H Type1 203 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6ZGCC 2.67 Inactive DFGin‑ABAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi H8H Type1 201 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6ZGCD 2.67 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii H8H Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6UNQA 2.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 206 - 496 0 None K493A Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6UNRA 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 208 - 496 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6SZMA 1.42 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi M2Z, M2Z, M2Z Allosteric, Allosteric, Type1 202 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7QB 1.53 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi XJM, LU8, XJM Allosteric, Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6JUXA 1.75 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi C9U Type1 203 - 499 0 None R206H Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 4DYMA 2.42 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IYZ Type1 207 - 499 0 None R206H Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6ACRA 2.01 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 9TO Type1 203 - 498 0 None R206H Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6ACRB 2.01 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 9TO Type1 203 - 498 0 None R206H Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 7C3GA 1.802 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi FH0 Type1 203 - 499 0 None R206H Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 7C3GB 1.802 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi FH0 Type1 204 - 499 0 None R206H Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 9L04A 2.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A1L4C Type1 203 - 499 0 None R206H Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 3MTFA 2.15 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 3MTFB 2.15 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 3OOMA 2.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 507 Type1 203 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 3Q4UA 1.82 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 3Q4UB 1.82 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 201 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 3Q4UC 1.82 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 3Q4UD 1.82 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 4BGGA 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 844 Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 4BGGB 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 844 Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 4BGGC 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 844 Type1 204 - 497 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 4BGGD 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 844 Type1 204 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5OXGA 2.13 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4B Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5OXGB 2.13 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4B Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5OXGC 2.13 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4B Type1 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5OXGD 2.13 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4B Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5OY6A 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4E Type1 204 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5OY6B 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4E Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5OY6C 2.56 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi B4E Type1 204 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5OY6D 2.56 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi B4E Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S77B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S78B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S79B 1.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7GB 1.78 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8 Type1 207 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7HB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7JB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 206 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7PB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7WB 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S83B 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S84B 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 206 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S89B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6GI6A 1.98 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi EZB Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6GINA 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IR2 Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6GINB 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IR2 Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6GIPA 2.17 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi EUN Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6SRHA 1.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6SZMB 1.42 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi M2Z Type1 205 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6T6DD 2.56 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii MM8 Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6T8NA 1.77 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi MVE Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6T8NB 1.77 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi MVE Type1 203 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6TN8A 1.63 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 5U6 Type1 204 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6Z36B 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi Q5Z Type1 204 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 7A21A 2.14 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi QWQ Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 7A21B 2.14 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi QWQ Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 7NNSB 2.14 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi C87 Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 8C7WA 2.26 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi U0C Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 8C7ZA 2.23 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi TZX Type1 204 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 8R7GA 2.09 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi YEE Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 8R7GB 2.09 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi YEE Type1 205 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 8R7GD 2.09 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi YEE Type1 204 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 9D8FA 1.86 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A3C Type1 193 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 9D8FB 1.86 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A3C Type1 200 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 8UWRA 2.04 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi XQX Type1 203 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 3H9RA 2.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi TAK Type1 172 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 4C02A 2.17 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii TAK Type1 178 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6I1SA 1.52 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi E26 Type1 172 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 9D8EA 1.72 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A29 Type1 193 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 9D8EB 1.72 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A29 Type1 193 - 498 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 9RDAA 1.748 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi A1JFB Type1 172 - 498 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 9D8ZA 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A3D Type1 203 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 9D8ZB 1.85 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1A3D Type1 193 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6UNSA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 204 - 496 0 None K492A,K493A Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6UNSB 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LDN Type1 204 - 496 0 None K492A,K493A Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6EIXA 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 192 - 503 0 None Q207E Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7BB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH7 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7CB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, T5Y Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7DB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XHD Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7EB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XEA Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7KB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XEJ Type1, Allosteric 205 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7MB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HVK Type1, Allosteric 208 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7NB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 2AI Type1, Allosteric 207 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7SB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 09V Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7VB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH1 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7XB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LGA Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7ZB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, BYZ Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S82B 1.71 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LU8, LAC Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S86B 1.31 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LU8, XK7 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S87B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKD Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S88B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKS Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S8AB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKY Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 8PODA 2.59 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 7IO, F Type1, Allosteric 172 - 498 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S75B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HUH, HUH Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S79A 1.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7AB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, T5V, T5V Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7EA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7FA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7FB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH4, XH4 Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7GA 1.78 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7OA 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7QA 1.53 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7UA 1.59 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7UB 1.59 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioi LU8, XGY, XGY Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7VA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7WA 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7YA 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S80A 1.67 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S80B 1.67 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGM, XGM Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S82A 1.71 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S87A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S88A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S9KA 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6SRHB 1.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6Z36A 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi Q5Z, Q5Z, Q5Z Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S77A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, BAQ Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7DA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XHD Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7JA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XHG Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7KA 1.31 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8, XEJ Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None None Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7LA 1.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XHJ Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7MA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, HVK, HVK Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7NA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, 2AI Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7PA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, V1L Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7SA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, 09V Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7TB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGJ, XGJ, XGJ Type1, Allosteric, Allosteric, Allosteric 205 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7XA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, LGA Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S86A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK7 Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S89A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XKV Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S8AA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XKY Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S8BB 1.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XFV, XFV, XFV Type1, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S75A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HUH, HUH Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7AA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, T5V, T5V Type1, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7BA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oioi LU8, LU8, LU8, XH7, XH7 Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7HA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HVB, HVB Type1, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7ZA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, BYZ, BYZ Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S81B 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJV, XJV, XJV, XJV Type1, Allosteric, Allosteric, Allosteric, Allosteric 208 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7CA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, T5Y, T5Y, T5Y Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7IA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HV2, HV2, HV2 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7TA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XGJ, XGJ, XGJ Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7YB 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJP, XJP, XJP, XJP, XJP Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 207 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7RB 1.46 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGS, XGS, XGS, XGS, XGS, XGS Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S85A 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK4, XK4, XK4, XK4 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S8BA 1.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XFV, XFV, XFV, XFV Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7RA 1.46 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XGS, XGS, XGS, XGS, XGS Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7IB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HV2, HV2, HV2, HV2, HV2, HV2, HV2, HV2, HV2 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S78A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XGV, XGV, XGV Type1, Allosteric, Allosteric, Allosteric, Allosteric, Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S81A 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XJV, XJV Type1, Allosteric, Allosteric, Allosteric, Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S76A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, 02A, 02A Type1, Allosteric, Allosteric, Allosteric, Type1.5_Back 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7LB 1.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XHJ, XHJ, XHJ, XHJ Type1, Allosteric, Allosteric, Allosteric, Type3 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S84A 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK1 Type1, Allosteric, Allosteric, Type1 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S83A 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XJY Type1, Allosteric, Allosteric, Type3 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S7OB 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJJ Type1, Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S85B 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XK4, XK4, XK4 Type1, Type1, Allosteric, Allosteric 207 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S76B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 02A Type1, Type1.5_Back 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 5S9KB 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, YV4 Type1, Type3 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 6T6DA 2.56 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii MM8 Type1 204 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
ACVR1_HUMAN 8R7GC 2.09 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii YEE Type1 206 - 498 0 None Q207D Activin receptor type-1 Homo sapiens

TKL_ACVR1 (Activin receptor type-1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism