All / All / Type1.5_Front

Total number of chains: 180
Active chains: 7
Total number of genes: 38
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 65 36.1% 4QTBA
DFGin None 24 13.3% 5HHWA
DFGin ABAminus 23 12.8% 6GR8A
DFGin BLBminus 18 10.0% 7QGPA
DFGin BLBplus 10 5.6% 7AVXA
DFGinter None 9 5.0% 9KS5B
DFGout BBAminus 9 5.0% 6PDJA
DFGin BLBtrans 7 3.9% 3VRZB
DFGin BLAplus 5 2.8% 7YAWB
DFGout None 5 2.8% 6HJKA
None None 5 2.8% 2C6EB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_label DFG-Asp_rotamer_label ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC AKT1 AKT1_HUMAN 3QKKA 2.3 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMH Type1.5_Front 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
AGC GRK2 ARBK1_HUMAN 5UUUA 2.7 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRW Type1.5_Front 31 - 538 0 None None Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UKKA 2.6 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8DJ Type1.5_Front 30 - 667 0 None S670A Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 6U7CA 2.44 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Q1Y Type1.5_Front 30 - 669 0 None None Beta-adrenergic receptor kinase 1
AGC PDPK1 PDPK1_HUMAN 3QCYA 2.2 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 3Q3 Type1.5_Front 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD0A 1.99 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 3Q4 Type1.5_Front 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD3A 2.0 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q5 Type1.5_Front 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD4A 2.3 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 3Q6 Type1.5_Front 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6C0TA 1.98 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-out nonTYR APEdihe_aaioi APEdist_iiii EE4 Type1.5_Front 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUA 2.8 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 65R Type1.5_Front 6 - 405 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUB 2.8 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 65R Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKSB 3.3 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaooi APEdist_iioo 6U1 Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKTB 2.8 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaoii APEdist_iioo 6U2 Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEA 2.6 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B4J Type1.5_Front 14 - 400 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEB 2.6 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aannn APEdist_nnnn B4J Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEC 2.6 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B4J Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNED 2.6 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B4J Type1.5_Front 7 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 7P6OC 2.75 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YK Type1.5_Front 22 - 417 0 None None Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OG 2.75 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YK Type1.5_Front 25 - 417 0 None None Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OH 2.75 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YK Type1.5_Front 24 - 417 0 None None Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6ED6B 2.86 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_nnno J0P Type1.5_Front 28 - 416 0 None None Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8GDSD 2.71 Inactive DFGout‑BBAminus DFGAsp-rot-in out-none in-none nonTYR APEdihe_aaiii APEdist_nnii Z8O Type1.5_Front 24 - 417 0 None None Rho-associated protein kinase 2
CAMK AURKA AURKA_HUMAN 6GRAA 2.6 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out none-none nonTYR APEdihe_aanni APEdist_nnnn F8Z Type1.5_Front 126 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3M11A 2.75 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaiii APEdist_nnno AKI Type1.5_Front 126 - 391 0 None T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 4JBPA 2.45 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnno YPH Type1.5_Front 126 - 390 0 None T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDA 3.2 Inactive DFGin‑None DFGAsp-rot-in out-out none-out nonTYR APEdihe_aaiii APEdist_nnno QMN Type1.5_Front 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDB 3.2 Inactive DFGin‑None DFGAsp-rot-in out-out none-out nonTYR APEdihe_aaiii APEdist_oooo QMN Type1.5_Front 125 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UYNA 1.9 Inactive DFGin‑None DFGAsp-rot-out out-out none-none nonTYR APEdihe_aannn APEdist_nnnn Y3M Type1.5_Front 125 - 391 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWA 2.29 Inactive DFGinter‑None DFGAsp-rot-in out-none none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWB 2.29 Inactive DFGinter‑None DFGAsp-rot-out out-out none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50A 2.0 Inactive DFGinter‑None DFGAsp-rot-in out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn LJE Type1.5_Front 126 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50B 2.0 Inactive DFGinter‑None DFGAsp-rot-in out-out none-out nonTYR APEdihe_aaioi APEdist_nnno LJE Type1.5_Front 126 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJJA 2.13 Inactive DFGinter‑None DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaioi APEdist_nnno G7T Type1.5_Front 127 - 393 0 None L210C,C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A 3.2 Inactive DFGout‑None DFGAsp-rot-in out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LJF Type1.5_Front 126 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJKA 2.4 Inactive DFGout‑None DFGAsp-rot-out out-none out-out nonTYR APEdihe_aaoii APEdist_nnoo G7W Type1.5_Front 127 - 391 0 None L210C,C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6EB 2.1 Inactive None‑None DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaooi APEdist_nnni HPM Type1.5_Front 127 - 388 0 None None Aurora kinase A
CAMK AURKC AURKC_HUMAN 6GR8A 1.75 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_iiii F8Z Type1.5_Front 36 - 303 0 TPO39,TPO198 None Aurora kinase C
CAMK SIK3 SIK3_HUMAN 8R4UA 2.416 Inactive DFGin‑BLAminus DFGAsp-rot-in in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UC 2.416 Inactive DFGin‑BLAminus DFGAsp-rot-in in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UE 2.416 Inactive DFGin‑BLAminus DFGAsp-rot-in in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UG 2.416 Inactive DFGin‑BLAminus DFGAsp-rot-in in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
CMGC DYRK1A DYR1A_HUMAN 6EIJC 2.42 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_iioi B5Z Type1.5_Front 135 - 479 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC MAPK1 MK01_HUMAN 6OPIA 3.0 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aanii APEdist_nnnn N0V Type1.5_Front 10 - 356 0 TPO185,PTR187 None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4QTAA 1.45 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 38Z Type1.5_Front 10 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9DA 1.8 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ER8 Type1.5_Front 8 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9HA 1.73 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_oiii ERW Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9JA 1.98 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ERK Type1.5_Front 8 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9KA 1.94 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ESK Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9NA 1.76 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_iioi ESN Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GDMA 1.91 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii F3Z Type1.5_Front 8 - 356 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GE0A 1.82 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii EVQ Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GJDA 1.58 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii F0E Type1.5_Front 10 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7AUVA 1.76 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_oiii RYW Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NQQA 1.943 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii UMN Type1.5_Front 11 - 356 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NQWA 1.775 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii UNW Type1.5_Front 11 - 356 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR5A 1.766 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_iioi UOH Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR8A 1.627 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii UOE Type1.5_Front 11 - 356 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR9A 1.906 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_oiii UOW Type1.5_Front 11 - 355 0 None None Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 3DA6A 2.0 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo BZ9 Type1.5_Front 46 - 401 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 4U79A 2.23 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 3EL Type1.5_Front 44 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK3 MK03_HUMAN 4QTBA 1.4 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 24 - 374 0 None None Mitogen-activated protein kinase 3
CMGC MAPK3 MK03_HUMAN 4QTBB 1.4 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 27 - 374 0 None None Mitogen-activated protein kinase 3
CMGC MAPK7 MK07_HUMAN 6HKNA 2.33 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out in-out nonTYR APEdihe_aaiii APEdist_oiii G9E Type1.5_Front 54 - 393 0 None None Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 6HKMA 2.47 Inactive DFGin‑BLAminus DFGAsp-rot-out in-out in-out nonTYR APEdihe_aaioi APEdist_oiii G92 Type1.5_Front 54 - 395 0 None None Mitogen-activated protein kinase 7
OTHER ERN1 ERN1_HUMAN 6W3EA 2.737 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out none-none nonTYR APEdihe_aannn APEdist_nnnn SJV Type1.5_Front 562 - 962 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDDA 2.4 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out in-out nonTYR APEdihe_aaiio APEdist_oiio N97 Type1.5_Front 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 8UVLA 2.43 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaiii APEdist_iooi XOE Type1.5_Front 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER HASPIN HASP_HUMAN 6Z5AA 1.55 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-na noAPE APEdihe_aaaaa APEdist_aaaa Q8B Type1.5_Front 465 - 798 0 None None Serine/threonine-protein kinase haspin
OTHER TTK TTK_HUMAN 6TNBA 2.65 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaini APEdist_nnno 8QW Type1.5_Front 517 - 794 0 TPO686 None Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N9SA 2.3 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaini APEdist_oooo 8QW Type1.5_Front 519 - 794 0 TPO686 None Dual specificity protein kinase TTK
STE MAP2K7 MP2K7_HUMAN 7OVIA 1.95 Inactive DFGin‑BLAplus DFGAsp-rot-out na-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2GI Type1.5_Front 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVJA 2.35 Inactive DFGin‑BLBplus DFGAsp-rot-out na-na none-none nonTYR APEdihe_aaiai APEdist_nnni 24N Type1.5_Front 102 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6IB2A 2.1 Inactive DFGin‑None DFGAsp-rot-in na-na none-none nonTYR APEdihe_aannn APEdist_nnnn 862 Type1.5_Front 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE PAK1 PAK1_HUMAN 5DFPA 2.2 Inactive DFGin‑BLAminus DFGAsp-rot-in out-none in-in nonTYR APEdihe_aaiii APEdist_iiii 59U Type1.5_Front 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1
STE SLK SLK_HUMAN 8BEMA 2.6 Inactive DFGout‑BBAminus DFGAsp-rot-in out-none none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1.5_Front 19 - 309 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMB 2.6 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1.5_Front 19 - 310 0 None None STE20-like serine/threonine-protein kinase
STE STK10 STK10_HUMAN 7QGPA 1.9 Inactive DFGin‑BLBminus DFGAsp-rot-in in-out out-out nonTYR APEdihe_aaiio APEdist_iioo DJ8 Type1.5_Front 23 - 313 0 None None Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 7B30A 2.1 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 59T Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B31A 1.8 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQ8 Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B32A 1.75 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQQ Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B33A 1.9 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQE Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B34A 2.1 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQK Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B35A 2.4 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQB Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B35B 2.4 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQB Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8BZJB 2.52 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none nonTYR APEdihe_aanii APEdist_nnnn SJX Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLRA 1.85 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYN Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLRB 1.85 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYN Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLSA 1.61 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYH Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLTA 1.47 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VZ2 Type1.5_Front 25 - 301 0 None None Serine/threonine-protein kinase 24
STE STK26 STK26_HUMAN 7B36A 2.107 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 59T Type1.5_Front 18 - 300 0 None None Serine/threonine-protein kinase 26
STE TNIK TNIK_HUMAN 7XZRA 2.26 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP Type1.5_Front 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
TKL MAP3K20 M3K20_HUMAN 7YAWB 2.1 Inactive DFGin‑BLAplus DFGAsp-rot-in out-out out-out nonTYR APEdihe_aaooi APEdist_oooo IGS Type1.5_Front 8 - 299 0 None None Mitogen-activated protein kinase kinase kinase 20
TKL MAP3K20 M3K20_HUMAN 7YAWC 2.1 Inactive DFGin‑BLAplus DFGAsp-rot-in out-out out-out nonTYR APEdihe_aaoii APEdist_oioo IGS Type1.5_Front 8 - 299 0 None None Mitogen-activated protein kinase kinase kinase 20
TKL RIPK3 RIPK3_HUMAN 7MONB 2.23 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaoii APEdist_oooo ZL1 Type1.5_Front 5 - 311 0 TPO224,SEP227 C3S,C110A Receptor-interacting serine/threonine-protein kinase 3
TYR ABL1 ABL1_HUMAN 4YC8A 2.9 Inactive DFGinter‑None DFGAsp-rot-out out-none out-in TYR APEdihe_iiiai APEdist_aaaa 4B7 Type1.5_Front 233 - 501 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8B 2.9 Inactive DFGinter‑None DFGAsp-rot-out out-none out-in TYR APEdihe_iiiai APEdist_aaaa 4B7 Type1.5_Front 233 - 502 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5A 2.2 Inactive DFGinter‑None DFGAsp-rot-out in-na out-in TYR APEdihe_iiiai APEdist_aaaa A1EG1 Type1.5_Front 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5B 2.2 Inactive DFGinter‑None DFGAsp-rot-out in-na out-in TYR APEdihe_iiiai APEdist_aaaa A1EG1 Type1.5_Front 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 4JOAA 2.7 Inactive DFGin‑ABAminus DFGAsp-rot-in in-out out-out TYR APEdihe_oiiai APEdist_aaaa 3DK Type1.5_Front 1107 - 1398 0 None S1281G ALK tyrosine kinase receptor
TYR EGFR EGFR_HUMAN 3W2OA 2.35 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-in TYR APEdihe_iiiai APEdist_aaaa 03P Type1.5_Front 698 - 1017 0 None T790M,L858R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3W2PA 2.05 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-in TYR APEdihe_iiiai APEdist_aaaa W2P Type1.5_Front 698 - 1018 0 None T790M,L858R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3W2QA 2.2 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-in TYR APEdihe_iiiai APEdist_aaaa HKI Type1.5_Front 698 - 1017 0 None T790M,L858R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKC 2.4 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_niiai APEdist_aaaa TQA Type1.5_Front 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXNC 1.76 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_nniai APEdist_aaaa UEJ Type1.5_Front 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXND 1.76 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-none TYR APEdihe_nniai APEdist_aaaa UEJ Type1.5_Front 702 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3A 2.49 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-none TYR APEdihe_nniai APEdist_aaaa IXC Type1.5_Front 702 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8PO3A 2.13 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nniai APEdist_aaaa 2II Type1.5_Front 706 - 1001 0 None V948R Epidermal growth factor receptor
TYR FGFR3 FGFR3_HUMAN 8UDUB 1.737 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in TYR APEdihe_iiiai APEdist_aaaa WIQ Type1.5_Front 459 - 755 0 None P572S,P573G Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTB 2.829 Inactive DFGin‑BLAplus DFGAsp-rot-out in-out out-out TYR APEdihe_nooai APEdist_aaaa WGF Type1.5_Front 457 - 754 0 None P572S,P573G Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTC 2.829 Inactive DFGin‑BLAplus DFGAsp-rot-out in-out out-out TYR APEdihe_nooai APEdist_aaaa WGF Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3
TYR HCK HCK_HUMAN 2C0IA 2.3 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa L1G Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0OA 2.85 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa L2G Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0TA 2.15 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa L3G Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0TB 2.15 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa L3G Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VRZA 2.218 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa VRZ Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VRZB 2.218 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nniai APEdist_aaaa VRZ Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 3F5PA 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PB 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PC 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PD 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PE 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PF 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PG 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PH 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PI 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PJ 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PK 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PL 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PM 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PR 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PS 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PT 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3D94A 2.3 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa D94 Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIAAA 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 986 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIBBB 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYICCC 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIDDD 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIEEE 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIFFF 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIGGG 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIHHH 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNA 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNB 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNC 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZND 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNE 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNF 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNG 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNH 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 5HHWA 1.79 Inactive DFGin‑None DFGAsp-rot-in in-out out-in TYR APEdihe_iiiai APEdist_aaaa 60O Type1.5_Front 1005 - 1310 0 None C1008S,D1159N Insulin receptor
TYR LCK LCK_HUMAN 6PDJA 1.81 Inactive DFGout‑BBAminus DFGAsp-rot-in out-none in-in TYR APEdihe_iiiai APEdist_aaaa ODJ Type1.5_Front 225 - 500 0 PTR394 None Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 7AAZA 1.855 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa R6K Type1.5_Front 574 - 863 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHIA 2.07 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa A1APF Type1.5_Front 578 - 864 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHJA 2.294 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out in-out TYR APEdihe_oiiai APEdist_aaaa A1APG Type1.5_Front 578 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHKA 2.106 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out in-out TYR APEdihe_oiiai APEdist_aaaa A1APH Type1.5_Front 578 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW2A 2.1 Inactive DFGin‑BLBminus DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa S4W Type1.5_Front 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLSA 1.89 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa VJZ Type1.5_Front 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLVA 2.13 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa VK2 Type1.5_Front 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLXA 1.98 Inactive DFGin‑BLBminus DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa VK5 Type1.5_Front 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AVXA 2.44 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_oiiai APEdist_aaaa S4K Type1.5_Front 577 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRZA 2.6 Inactive DFGout‑None DFGAsp-rot-in out-none none-none TYR APEdihe_nnnai APEdist_aaaa A1L6K Type1.5_Front 577 - 864 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRZB 2.6 Inactive DFGout‑None DFGAsp-rot-in out-none none-none TYR APEdihe_nnnai APEdist_aaaa A1L6K Type1.5_Front 575 - 863 0 None None Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3U6HA 2.0 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa 03X Type1.5_Front 1051 - 1351 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3U6IA 2.1 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_nniai APEdist_aaaa 044 Type1.5_Front 1051 - 1351 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKA 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKB 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8ANSA 2.01 Inactive DFGout‑BBAminus DFGAsp-rot-in out-none in-none TYR APEdihe_nniai APEdist_aaaa MDI Type1.5_Front 1052 - 1346 0 None D1228V Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8VI1A 3.11 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa A1AB1 Type1.5_Front 1053 - 1346 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8VI1B 3.11 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa A1AB1 Type1.5_Front 1050 - 1345 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AN8A 2.394 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out in-none TYR APEdihe_nnnai APEdist_aaaa MDI Type1.5_Front 1073 - 1345 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AN8B 2.394 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out in-none TYR APEdihe_nniai APEdist_aaaa MDI Type1.5_Front 1058 - 1345 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFJA 2.6 Inactive DFGout‑None DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
TYR MET MET_HUMAN 5T3QA 2.0 Inactive None‑None DFGAsp-rot-out out-out none-none TYR APEdihe_nniai APEdist_aaaa 75H Type1.5_Front 1050 - 1350 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 2RFNA 2.5 Inactive None‑None DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa AM7 Type1.5_Front 1057 - 1351 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 2RFNB 2.5 Inactive None‑None DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa AM7 Type1.5_Front 1056 - 1351 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFJB 2.6 Inactive None‑None DFGAsp-rot-in out-none none-none TYR APEdihe_nnnai APEdist_aaaa MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
TYR RET RET_HUMAN 7DU8A 2.75 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out TYR APEdihe_oiiai APEdist_aaaa Q6G Type1.5_Front 714 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7DU8B 2.75 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out TYR APEdihe_oiiai APEdist_aaaa Q6G Type1.5_Front 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7JU6B 2.06 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out TYR APEdihe_oiiai APEdist_aaaa Q6G Type1.5_Front 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR SYK KSYK_HUMAN 3TUCA 2.1 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa FPW Type1.5_Front 358 - 633 0 None None Tyrosine-protein kinase SYK

All / All / Type1.5_Front

Total number of chains: 213
Active chains: 7
Total number of genes: 47
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 80 37.6% 4QTBA
DFGin ABAminus 27 12.7% 4C2VA
DFGin None 27 12.7% 5HHWA
DFGin BLBminus 21 9.9% 7QGPA
DFGin BLBplus 17 8.0% 9EJSA
DFGinter None 9 4.2% 9KS5B
DFGout BBAminus 9 4.2% 6PDJA
DFGin BLBtrans 8 3.8% 5DRBA
DFGin BLAplus 5 2.3% 7YAWB
DFGout None 5 2.3% 6HJKA
None None 5 2.3% 2C6EB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_label DFG-Asp_rotamer_label ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC GRK5 GRK5_BOVIN 4WNKA 2.42 Inactive DFGin‑ABAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1.5_Front 24 - 541 0 None None G protein-coupled receptor kinase 5 Bos taurus
AGC PRKACA KAPCA_BOVIN 1XH9A 1.64 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii R69 Type1.5_Front 14 - 351 0 TPO198,SEP339 Q85E,V124A,L174M,Q182K,F188L cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 1SVHA 2.3 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii I08 Type1.5_Front 15 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
CAMK PLK1 Q4KMI8_DANRE 3DB6A 2.85 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaiio APEdist_ioio FRS Type1.5_Front 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
TYR SRC SRC_CHICK 4DGGA 2.65 Inactive DFGin‑BLBminus DFGAsp-rot-in out-none none-none TYR APEdihe_nniai APEdist_aaaa I76 Type1.5_Front 256 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5J5SA 2.153 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa 6G3 Type1.5_Front 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5J5SB 2.153 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa 6G3 Type1.5_Front 256 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3QLFB 2.75 Inactive DFGin‑None DFGAsp-rot-in out-none in-none TYR APEdihe_nniai APEdist_aaaa PD5 Type1.5_Front 258 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
AGC AKT1 AKT1_HUMAN 3QKKA 2.3 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMH Type1.5_Front 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC GRK2 ARBK1_HUMAN 5UUUA 2.7 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRW Type1.5_Front 31 - 538 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
AGC GRK2 ARBK1_HUMAN 5UKKA 2.6 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8DJ Type1.5_Front 30 - 667 0 None S670A Beta-adrenergic receptor kinase 1 Homo sapiens
AGC GRK2 ARBK1_HUMAN 6U7CA 2.44 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Q1Y Type1.5_Front 30 - 669 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3QCYA 2.2 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 3Q3 Type1.5_Front 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3QD0A 1.99 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 3Q4 Type1.5_Front 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3QD3A 2.0 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q5 Type1.5_Front 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3QD4A 2.3 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 3Q6 Type1.5_Front 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 6C0TA 1.98 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-out nonTYR APEdihe_aaioi APEdist_iiii EE4 Type1.5_Front 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 5HVUA 2.8 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 65R Type1.5_Front 6 - 405 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 5HVUB 2.8 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 65R Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 5KKSB 3.3 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaooi APEdist_iioo 6U1 Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 5KKTB 2.8 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaoii APEdist_iioo 6U2 Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 5WNEA 2.6 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B4J Type1.5_Front 14 - 400 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 5WNEB 2.6 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aannn APEdist_nnnn B4J Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 5WNEC 2.6 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B4J Type1.5_Front 6 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 5WNED 2.6 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii B4J Type1.5_Front 7 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK2 ROCK2_HUMAN 7P6OC 2.75 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YK Type1.5_Front 22 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
AGC ROCK2 ROCK2_HUMAN 7P6OG 2.75 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YK Type1.5_Front 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
AGC ROCK2 ROCK2_HUMAN 7P6OH 2.75 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YK Type1.5_Front 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
AGC ROCK2 ROCK2_HUMAN 6ED6B 2.86 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_nnno J0P Type1.5_Front 28 - 416 0 None None Rho-associated protein kinase 2 Homo sapiens
AGC ROCK2 ROCK2_HUMAN 8GDSD 2.71 Inactive DFGout‑BBAminus DFGAsp-rot-in out-none in-none nonTYR APEdihe_aaiii APEdist_nnii Z8O Type1.5_Front 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
CAMK AURKA AURKA_HUMAN 6GRAA 2.6 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out none-none nonTYR APEdihe_aanni APEdist_nnnn F8Z Type1.5_Front 126 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3M11A 2.75 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaiii APEdist_nnno AKI Type1.5_Front 126 - 391 0 None T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4JBPA 2.45 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnno YPH Type1.5_Front 126 - 390 0 None T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4UZDA 3.2 Inactive DFGin‑None DFGAsp-rot-in out-out none-out nonTYR APEdihe_aaiii APEdist_nnno QMN Type1.5_Front 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4UZDB 3.2 Inactive DFGin‑None DFGAsp-rot-in out-out none-out nonTYR APEdihe_aaiii APEdist_oooo QMN Type1.5_Front 125 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4UYNA 1.9 Inactive DFGin‑None DFGAsp-rot-out out-out none-none nonTYR APEdihe_aannn APEdist_nnnn Y3M Type1.5_Front 125 - 391 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3EFWA 2.29 Inactive DFGinter‑None DFGAsp-rot-in out-none none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3EFWB 2.29 Inactive DFGinter‑None DFGAsp-rot-out out-out none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3O50A 2.0 Inactive DFGinter‑None DFGAsp-rot-in out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn LJE Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3O50B 2.0 Inactive DFGinter‑None DFGAsp-rot-in out-out none-out nonTYR APEdihe_aaioi APEdist_nnno LJE Type1.5_Front 126 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6HJJA 2.13 Inactive DFGinter‑None DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaioi APEdist_nnno G7T Type1.5_Front 127 - 393 0 None L210C,C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3O51A 3.2 Inactive DFGout‑None DFGAsp-rot-in out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LJF Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6HJKA 2.4 Inactive DFGout‑None DFGAsp-rot-out out-none out-out nonTYR APEdihe_aaoii APEdist_nnoo G7W Type1.5_Front 127 - 391 0 None L210C,C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2C6EB 2.1 Inactive None‑None DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaooi APEdist_nnni HPM Type1.5_Front 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKC AURKC_HUMAN 6GR8A 1.75 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_iiii F8Z Type1.5_Front 36 - 303 0 TPO39,TPO198 None Aurora kinase C Homo sapiens
CAMK SIK3 SIK3_HUMAN 8R4UA 2.416 Inactive DFGin‑BLAminus DFGAsp-rot-in in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
CAMK SIK3 SIK3_HUMAN 8R4UC 2.416 Inactive DFGin‑BLAminus DFGAsp-rot-in in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
CAMK SIK3 SIK3_HUMAN 8R4UE 2.416 Inactive DFGin‑BLAminus DFGAsp-rot-in in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
CAMK SIK3 SIK3_HUMAN 8R4UG 2.416 Inactive DFGin‑BLAminus DFGAsp-rot-in in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 6EIJC 2.42 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_iioi B5Z Type1.5_Front 135 - 479 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC MAPK1 MK01_HUMAN 6OPIA 3.0 None DFGin‑BLAminus DFGAsp-rot-in in-in in-none nonTYR APEdihe_aanii APEdist_nnnn N0V Type1.5_Front 10 - 356 0 TPO185,PTR187 None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4QTAA 1.45 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 38Z Type1.5_Front 10 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6G9DA 1.8 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ER8 Type1.5_Front 8 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6G9HA 1.73 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_oiii ERW Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6G9JA 1.98 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ERK Type1.5_Front 8 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6G9KA 1.94 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ESK Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6G9NA 1.76 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_iioi ESN Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6GDMA 1.91 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii F3Z Type1.5_Front 8 - 356 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6GE0A 1.82 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii EVQ Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6GJDA 1.58 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii F0E Type1.5_Front 10 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 7AUVA 1.76 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_oiii RYW Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 7NQQA 1.943 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii UMN Type1.5_Front 11 - 356 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 7NQWA 1.775 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii UNW Type1.5_Front 11 - 356 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 7NR5A 1.766 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_iioi UOH Type1.5_Front 11 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 7NR8A 1.627 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii UOE Type1.5_Front 11 - 356 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 7NR9A 1.906 Inactive DFGin‑BLAminus DFGAsp-rot-in out-in in-out nonTYR APEdihe_aaiii APEdist_oiii UOW Type1.5_Front 11 - 355 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK10 MK10_HUMAN 3DA6A 2.0 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo BZ9 Type1.5_Front 46 - 401 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 4U79A 2.23 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 3EL Type1.5_Front 44 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK3 MK03_HUMAN 4QTBA 1.4 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 24 - 374 0 None None Mitogen-activated protein kinase 3 Homo sapiens
CMGC MAPK3 MK03_HUMAN 4QTBB 1.4 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 27 - 374 0 None None Mitogen-activated protein kinase 3 Homo sapiens
CMGC MAPK7 MK07_HUMAN 6HKNA 2.33 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out in-out nonTYR APEdihe_aaiii APEdist_oiii G9E Type1.5_Front 54 - 393 0 None None Mitogen-activated protein kinase 7 Homo sapiens
CMGC MAPK7 MK07_HUMAN 6HKMA 2.47 Inactive DFGin‑BLAminus DFGAsp-rot-out in-out in-out nonTYR APEdihe_aaioi APEdist_oiii G92 Type1.5_Front 54 - 395 0 None None Mitogen-activated protein kinase 7 Homo sapiens
OTHER ERN1 ERN1_HUMAN 6W3EA 2.737 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out none-none nonTYR APEdihe_aannn APEdist_nnnn SJV Type1.5_Front 562 - 962 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 6XDDA 2.4 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out in-out nonTYR APEdihe_aaiio APEdist_oiio N97 Type1.5_Front 560 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 8UVLA 2.43 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaiii APEdist_iooi XOE Type1.5_Front 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER HASPIN HASP_HUMAN 6Z5AA 1.55 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-na noAPE APEdihe_aaaaa APEdist_aaaa Q8B Type1.5_Front 465 - 798 0 None None Serine/threonine-protein kinase haspin Homo sapiens
OTHER TTK TTK_HUMAN 6TNBA 2.65 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaini APEdist_nnno 8QW Type1.5_Front 517 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
OTHER TTK TTK_HUMAN 5N9SA 2.3 Inactive DFGin‑ABAminus DFGAsp-rot-out out-out out-out nonTYR APEdihe_aaini APEdist_oooo 8QW Type1.5_Front 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVIA 1.95 Inactive DFGin‑BLAplus DFGAsp-rot-out na-na none-none nonTYR APEdihe_aannn APEdist_nnnn 2GI Type1.5_Front 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7OVJA 2.35 Inactive DFGin‑BLBplus DFGAsp-rot-out na-na none-none nonTYR APEdihe_aaiai APEdist_nnni 24N Type1.5_Front 102 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6IB2A 2.1 Inactive DFGin‑None DFGAsp-rot-in na-na none-none nonTYR APEdihe_aannn APEdist_nnnn 862 Type1.5_Front 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE PAK1 PAK1_HUMAN 5DFPA 2.2 Inactive DFGin‑BLAminus DFGAsp-rot-in out-none in-in nonTYR APEdihe_aaiii APEdist_iiii 59U Type1.5_Front 249 - 541 0 TPO423 K299R Serine/threonine-protein kinase PAK 1 Homo sapiens
STE SLK SLK_HUMAN 8BEMA 2.6 Inactive DFGout‑BBAminus DFGAsp-rot-in out-none none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1.5_Front 19 - 309 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 8BEMB 2.6 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out none-out nonTYR APEdihe_aaioi APEdist_nnno AV9 Type1.5_Front 19 - 310 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE STK10 STK10_HUMAN 7QGPA 1.9 Inactive DFGin‑BLBminus DFGAsp-rot-in in-out out-out nonTYR APEdihe_aaiio APEdist_iioo DJ8 Type1.5_Front 23 - 313 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK24 STK24_HUMAN 7B30A 2.1 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 59T Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B31A 1.8 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQ8 Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B32A 1.75 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQQ Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B33A 1.9 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQE Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B34A 2.1 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQK Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B35A 2.4 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQB Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 7B35B 2.4 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn SQB Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8BZJB 2.52 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none nonTYR APEdihe_aanii APEdist_nnnn SJX Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLRA 1.85 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYN Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLRB 1.85 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYN Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLSA 1.61 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VYH Type1.5_Front 26 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 8QLTA 1.47 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn VZ2 Type1.5_Front 25 - 301 0 None None Serine/threonine-protein kinase 24 Homo sapiens
STE STK26 STK26_HUMAN 7B36A 2.107 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 59T Type1.5_Front 18 - 300 0 None None Serine/threonine-protein kinase 26 Homo sapiens
STE TNIK TNIK_HUMAN 7XZRA 2.26 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP Type1.5_Front 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
TKL MAP3K20 M3K20_HUMAN 7YAWB 2.1 Inactive DFGin‑BLAplus DFGAsp-rot-in out-out out-out nonTYR APEdihe_aaooi APEdist_oooo IGS Type1.5_Front 8 - 299 0 None None Mitogen-activated protein kinase kinase kinase 20 Homo sapiens
TKL MAP3K20 M3K20_HUMAN 7YAWC 2.1 Inactive DFGin‑BLAplus DFGAsp-rot-in out-out out-out nonTYR APEdihe_aaoii APEdist_oioo IGS Type1.5_Front 8 - 299 0 None None Mitogen-activated protein kinase kinase kinase 20 Homo sapiens
TKL RIPK3 RIPK3_HUMAN 7MONB 2.23 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaoii APEdist_oooo ZL1 Type1.5_Front 5 - 311 0 TPO224,SEP227 C3S,C110A Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens
TYR ABL1 ABL1_HUMAN 4YC8A 2.9 Inactive DFGinter‑None DFGAsp-rot-out out-none out-in TYR APEdihe_iiiai APEdist_aaaa 4B7 Type1.5_Front 233 - 501 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4YC8B 2.9 Inactive DFGinter‑None DFGAsp-rot-out out-none out-in TYR APEdihe_iiiai APEdist_aaaa 4B7 Type1.5_Front 233 - 502 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 9KS5A 2.2 Inactive DFGinter‑None DFGAsp-rot-out in-na out-in TYR APEdihe_iiiai APEdist_aaaa A1EG1 Type1.5_Front 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 9KS5B 2.2 Inactive DFGinter‑None DFGAsp-rot-out in-na out-in TYR APEdihe_iiiai APEdist_aaaa A1EG1 Type1.5_Front 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ALK ALK_HUMAN 4JOAA 2.7 Inactive DFGin‑ABAminus DFGAsp-rot-in in-out out-out TYR APEdihe_oiiai APEdist_aaaa 3DK Type1.5_Front 1107 - 1398 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3W2OA 2.35 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-in TYR APEdihe_iiiai APEdist_aaaa 03P Type1.5_Front 698 - 1017 0 None T790M,L858R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3W2PA 2.05 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-in TYR APEdihe_iiiai APEdist_aaaa W2P Type1.5_Front 698 - 1018 0 None T790M,L858R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3W2QA 2.2 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-in TYR APEdihe_iiiai APEdist_aaaa HKI Type1.5_Front 698 - 1017 0 None T790M,L858R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6WAKC 2.4 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_niiai APEdist_aaaa TQA Type1.5_Front 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6WXNC 1.76 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_nniai APEdist_aaaa UEJ Type1.5_Front 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6WXND 1.76 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-none TYR APEdihe_nniai APEdist_aaaa UEJ Type1.5_Front 702 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8TO3A 2.49 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-none TYR APEdihe_nniai APEdist_aaaa IXC Type1.5_Front 702 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8PO3A 2.13 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nniai APEdist_aaaa 2II Type1.5_Front 706 - 1001 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR FGFR3 FGFR3_HUMAN 8UDUB 1.737 Active DFGin‑BLAminus DFGAsp-rot-in in-in in-in TYR APEdihe_iiiai APEdist_aaaa WIQ Type1.5_Front 459 - 755 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
TYR FGFR3 FGFR3_HUMAN 8UDTB 2.829 Inactive DFGin‑BLAplus DFGAsp-rot-out in-out out-out TYR APEdihe_nooai APEdist_aaaa WGF Type1.5_Front 457 - 754 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
TYR FGFR3 FGFR3_HUMAN 8UDTC 2.829 Inactive DFGin‑BLAplus DFGAsp-rot-out in-out out-out TYR APEdihe_nooai APEdist_aaaa WGF Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
TYR HCK HCK_HUMAN 2C0IA 2.3 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa L1G Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 2C0OA 2.85 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa L2G Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 2C0TA 2.15 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa L3G Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 2C0TB 2.15 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa L3G Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 3VRZA 2.218 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nnnai APEdist_aaaa VRZ Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 3VRZB 2.218 Inactive DFGin‑BLBtrans DFGAsp-rot-out out-out out-none TYR APEdihe_nniai APEdist_aaaa VRZ Type1.5_Front 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PA 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PB 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PC 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PD 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PE 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PF 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PG 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PH 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PI 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PJ 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PK 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PL 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PM 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PR 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PS 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3F5PT 2.9 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3D94A 2.3 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa D94 Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIAAA 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 986 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIBBB 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYICCC 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIDDD 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIEEE 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIFFF 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIGGG 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYIHHH 3.06 Inactive DFGin‑None DFGAsp-rot-in out-out out-none TYR APEdihe_niiai APEdist_aaaa IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNA 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNB 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNC 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZND 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNE 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNF 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNG 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 5HZNH 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa 66A Type1.5_Front 983 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR INSR INSR_HUMAN 5HHWA 1.79 Inactive DFGin‑None DFGAsp-rot-in in-out out-in TYR APEdihe_iiiai APEdist_aaaa 60O Type1.5_Front 1005 - 1310 0 None C1008S,D1159N Insulin receptor Homo sapiens
TYR LCK LCK_HUMAN 6PDJA 1.81 Inactive DFGout‑BBAminus DFGAsp-rot-in out-none in-in TYR APEdihe_iiiai APEdist_aaaa ODJ Type1.5_Front 225 - 500 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
TYR MERTK MERTK_HUMAN 7AAZA 1.855 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa R6K Type1.5_Front 574 - 863 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9BHIA 2.07 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out TYR APEdihe_oiiai APEdist_aaaa A1APF Type1.5_Front 578 - 864 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9BHJA 2.294 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out in-out TYR APEdihe_oiiai APEdist_aaaa A1APG Type1.5_Front 578 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9BHKA 2.106 Inactive DFGin‑BLAminus DFGAsp-rot-out out-out in-out TYR APEdihe_oiiai APEdist_aaaa A1APH Type1.5_Front 578 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AW2A 2.1 Inactive DFGin‑BLBminus DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa S4W Type1.5_Front 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7OLSA 1.89 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa VJZ Type1.5_Front 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7OLVA 2.13 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa VK2 Type1.5_Front 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7OLXA 1.98 Inactive DFGin‑BLBminus DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa VK5 Type1.5_Front 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AVXA 2.44 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_oiiai APEdist_aaaa S4K Type1.5_Front 577 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9KRZA 2.6 Inactive DFGout‑None DFGAsp-rot-in out-none none-none TYR APEdihe_nnnai APEdist_aaaa A1L6K Type1.5_Front 577 - 864 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9KRZB 2.6 Inactive DFGout‑None DFGAsp-rot-in out-none none-none TYR APEdihe_nnnai APEdist_aaaa A1L6K Type1.5_Front 575 - 863 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MET MET_HUMAN 3U6HA 2.0 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa 03X Type1.5_Front 1051 - 1351 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3U6IA 2.1 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_nniai APEdist_aaaa 044 Type1.5_Front 1051 - 1351 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3EFKA 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3EFKB 2.2 Inactive DFGin‑None DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8ANSA 2.01 Inactive DFGout‑BBAminus DFGAsp-rot-in out-none in-none TYR APEdihe_nniai APEdist_aaaa MDI Type1.5_Front 1052 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8VI1A 3.11 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa A1AB1 Type1.5_Front 1053 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8VI1B 3.11 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out out-in TYR APEdihe_iiiai APEdist_aaaa A1AB1 Type1.5_Front 1050 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8AN8A 2.394 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out in-none TYR APEdihe_nnnai APEdist_aaaa MDI Type1.5_Front 1073 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 8AN8B 2.394 Inactive DFGout‑BBAminus DFGAsp-rot-in out-out in-none TYR APEdihe_nniai APEdist_aaaa MDI Type1.5_Front 1058 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3EFJA 2.6 Inactive DFGout‑None DFGAsp-rot-in out-out none-none TYR APEdihe_nnnai APEdist_aaaa MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 5T3QA 2.0 Inactive None‑None DFGAsp-rot-out out-out none-none TYR APEdihe_nniai APEdist_aaaa 75H Type1.5_Front 1050 - 1350 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 2RFNA 2.5 Inactive None‑None DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa AM7 Type1.5_Front 1057 - 1351 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 2RFNB 2.5 Inactive None‑None DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa AM7 Type1.5_Front 1056 - 1351 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3EFJB 2.6 Inactive None‑None DFGAsp-rot-in out-none none-none TYR APEdihe_nnnai APEdist_aaaa MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
TYR RET RET_HUMAN 7DU8A 2.75 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out TYR APEdihe_oiiai APEdist_aaaa Q6G Type1.5_Front 714 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 7DU8B 2.75 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out TYR APEdihe_oiiai APEdist_aaaa Q6G Type1.5_Front 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 7JU6B 2.06 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out TYR APEdihe_oiiai APEdist_aaaa Q6G Type1.5_Front 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR SYK KSYK_HUMAN 3TUCA 2.1 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa FPW Type1.5_Front 358 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
CAMK AURKA AURKA_MOUSE 3D14A 1.9 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK1 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3D15A 2.3 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnno AK2 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3D2IA 2.9 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK3 Type1.5_Front 118 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3D2KA 2.5 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aanoi APEdist_nnnn AK4 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ7A 2.8 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK7 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ5A 1.8 Inactive DFGin‑None DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK5 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ6A 1.7 Inactive DFGin‑None DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK6 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
TYR BTK BTK_MOUSE 9EJJA 2.03 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_oooai APEdist_aaaa A1BIZ Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJJB 2.03 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_iooai APEdist_aaaa A1BIZ Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJRA 2.1 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_iooai APEdist_aaaa A1BI0 Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJRB 2.1 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_iooai APEdist_aaaa A1BI0 Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJSA 2.26 Inactive DFGin‑BLBplus DFGAsp-rot-out out-none out-out TYR APEdihe_oiiai APEdist_aaaa A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJSB 2.26 Inactive DFGin‑BLBplus DFGAsp-rot-out out-none out-out TYR APEdihe_oiiai APEdist_aaaa A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJSC 2.26 Inactive DFGin‑BLBplus DFGAsp-rot-out out-none out-out TYR APEdihe_oiiai APEdist_aaaa A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
CMGC MPS1 MPS1_PYRO7 8H59A 2.15 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_iooi KR9 Type1.5_Front 5 - 412 0 None None Mitogen-activated protein kinase MPS1 Pyricularia oryzae
CMGC MAPK1 MK01_RAT 4XOZA 1.95 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaiii APEdist_oiii 620 Type1.5_Front 8 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 4QYYA 1.65 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 3G7 Type1.5_Front 13 - 353 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 5HD4A 1.45 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 9 - 355 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 6CPWA 1.85 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii F8V Type1.5_Front 16 - 355 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 6DCGA 1.45 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii G67 Type1.5_Front 16 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
OTHER WNK1 WNK1_RAT 5DRBA 1.65 Inactive DFGin‑BLBtrans DFGAsp-rot-out na-na out-out nonTYR APEdihe_aaioo APEdist_oooo 5FJ Type1.5_Front 209 - 481 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus
OTHER BUD32 BUD32_YEAST 4WW5A 1.997 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Type1.5_Front 5 - 257 0 None None EKC/KEOPS complex subunit BUD32 Saccharomyces cerevisiae
CAMK AURKBA AUKBA_XENLA 2VRXA 1.86 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 447 Type1.5_Front 87 - 355 0 TPO248 None Aurora kinase B-A Xenopus laevis
CAMK AURKBA AUKBA_XENLA 4C2VA 1.49 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJA Type1.5_Front 87 - 357 0 TPO248 None Aurora kinase B-A Xenopus laevis
CAMK AURKBA AUKBA_XENLA 4C2VB 1.49 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJA Type1.5_Front 76 - 356 0 TPO248 None Aurora kinase B-A Xenopus laevis

All / All / Type1.5_Front

Total number of chains: 33
Active chains: 0
Total number of genes: 11
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 15 45.5% 5HD4A
DFGin BLBplus 7 21.2% 9EJSA
DFGin ABAminus 4 12.1% 4C2VA
DFGin BLBminus 3 9.1% 4DGGA
DFGin None 3 9.1% 3DJ6A
DFGin BLBtrans 1 3.0% 5DRBA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_label DFG-Asp_rotamer_label ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC GRK5 GRK5_BOVIN 4WNKA 2.42 Inactive DFGin‑ABAminus DFGAsp-rot-in in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1.5_Front 24 - 541 0 None None G protein-coupled receptor kinase 5 Bos taurus
AGC PRKACA KAPCA_BOVIN 1XH9A 1.64 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii R69 Type1.5_Front 14 - 351 0 TPO198,SEP339 Q85E,V124A,L174M,Q182K,F188L cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 1SVHA 2.3 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-in nonTYR APEdihe_aaiii APEdist_iiii I08 Type1.5_Front 15 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
CAMK PLK1 Q4KMI8_DANRE 3DB6A 2.85 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaiio APEdist_ioio FRS Type1.5_Front 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
TYR SRC SRC_CHICK 4DGGA 2.65 Inactive DFGin‑BLBminus DFGAsp-rot-in out-none none-none TYR APEdihe_nniai APEdist_aaaa I76 Type1.5_Front 256 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5J5SA 2.153 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa 6G3 Type1.5_Front 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5J5SB 2.153 Inactive DFGin‑BLBminus DFGAsp-rot-out out-out none-none TYR APEdihe_nnnai APEdist_aaaa 6G3 Type1.5_Front 256 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3QLFB 2.75 Inactive DFGin‑None DFGAsp-rot-in out-none in-none TYR APEdihe_nniai APEdist_aaaa PD5 Type1.5_Front 258 - 533 0 None L317I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
CAMK AURKA AURKA_MOUSE 3D14A 1.9 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK1 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3D15A 2.3 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnno AK2 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3D2IA 2.9 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK3 Type1.5_Front 118 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3D2KA 2.5 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aanoi APEdist_nnnn AK4 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ7A 2.8 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaioi APEdist_nnoo AK7 Type1.5_Front 117 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ5A 1.8 Inactive DFGin‑None DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK5 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
CAMK AURKA AURKA_MOUSE 3DJ6A 1.7 Inactive DFGin‑None DFGAsp-rot-out out-out none-out nonTYR APEdihe_aaiii APEdist_oooo AK6 Type1.5_Front 119 - 379 0 None N164G,K218R,M280L Aurora kinase A Mus musculus
TYR BTK BTK_MOUSE 9EJJA 2.03 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_oooai APEdist_aaaa A1BIZ Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJJB 2.03 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_iooai APEdist_aaaa A1BIZ Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJRA 2.1 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_iooai APEdist_aaaa A1BI0 Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJRB 2.1 Inactive DFGin‑BLBplus DFGAsp-rot-out out-out out-out TYR APEdihe_iooai APEdist_aaaa A1BI0 Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJSA 2.26 Inactive DFGin‑BLBplus DFGAsp-rot-out out-none out-out TYR APEdihe_oiiai APEdist_aaaa A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJSB 2.26 Inactive DFGin‑BLBplus DFGAsp-rot-out out-none out-out TYR APEdihe_oiiai APEdist_aaaa A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 9EJSC 2.26 Inactive DFGin‑BLBplus DFGAsp-rot-out out-none out-out TYR APEdihe_oiiai APEdist_aaaa A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
CMGC MPS1 MPS1_PYRO7 8H59A 2.15 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_iooi KR9 Type1.5_Front 5 - 412 0 None None Mitogen-activated protein kinase MPS1 Pyricularia oryzae
CMGC MAPK1 MK01_RAT 4XOZA 1.95 Inactive DFGin‑BLAminus DFGAsp-rot-in out-out in-out nonTYR APEdihe_aaiii APEdist_oiii 620 Type1.5_Front 8 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 4QYYA 1.65 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 3G7 Type1.5_Front 13 - 353 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 5HD4A 1.45 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 9 - 355 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 6CPWA 1.85 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii F8V Type1.5_Front 16 - 355 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 6DCGA 1.45 Inactive DFGin‑BLAminus DFGAsp-rot-in in-in in-out nonTYR APEdihe_aaiii APEdist_oiii G67 Type1.5_Front 16 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
OTHER WNK1 WNK1_RAT 5DRBA 1.65 Inactive DFGin‑BLBtrans DFGAsp-rot-out na-na out-out nonTYR APEdihe_aaioo APEdist_oooo 5FJ Type1.5_Front 209 - 481 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus
OTHER BUD32 BUD32_YEAST 4WW5A 1.997 Inactive DFGin‑BLAminus DFGAsp-rot-out in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Type1.5_Front 5 - 257 0 None None EKC/KEOPS complex subunit BUD32 Saccharomyces cerevisiae
CAMK AURKBA AUKBA_XENLA 2VRXA 1.86 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 447 Type1.5_Front 87 - 355 0 TPO248 None Aurora kinase B-A Xenopus laevis
CAMK AURKBA AUKBA_XENLA 4C2VA 1.49 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJA Type1.5_Front 87 - 357 0 TPO248 None Aurora kinase B-A Xenopus laevis
CAMK AURKBA AUKBA_XENLA 4C2VB 1.49 Inactive DFGin‑ABAminus DFGAsp-rot-in out-out in-in nonTYR APEdihe_aaiii APEdist_iiii YJA Type1.5_Front 76 - 356 0 TPO248 None Aurora kinase B-A Xenopus laevis